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Conserved domains on  [gi|213417964|ref|NP_001132991|]
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Z-DNA-binding protein 1 isoform 2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
z-alpha super family cl02659
Adenosine deaminase z-alpha domain; This family consists of the N-terminus and thus the ...
 8-72 5.87e-17

Adenosine deaminase z-alpha domain; This family consists of the N-terminus and thus the z-alpha domain of double-stranded RNA-specific adenosine deaminase (ADAR), an RNA- editing enzyme. The z-alpha domain is a Z-DNA binding domain, and binding of this region to B-DNA has been shown to be disfavoured by steric hindrance.


The actual alignment was detected with superfamily member smart00550:

Pssm-ID: 295419  Cd Length: 68  Bit Score: 71.21  E-value: 5.87e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 213417964     8 LSTGDNLEQKILQVLSDDGGP-VKIGQLVKKCQVPKKTLNQVLYRLKKEDRVSSP--EPATWSIGGAA 72
Cdd:smart00550   1 SLTQDSLEEKILEFLENSGDEtSTALQLAKNLGLPKKEVNRVLYSLEKKGKVCKQggTPPLWKLTDKA 68
z-alpha super family cl02659
Adenosine deaminase z-alpha domain; This family consists of the N-terminus and thus the ...
 84-147 1.10e-16

Adenosine deaminase z-alpha domain; This family consists of the N-terminus and thus the z-alpha domain of double-stranded RNA-specific adenosine deaminase (ADAR), an RNA- editing enzyme. The z-alpha domain is a Z-DNA binding domain, and binding of this region to B-DNA has been shown to be disfavoured by steric hindrance.


The actual alignment was detected with superfamily member smart00550:

Pssm-ID: 295419  Cd Length: 68  Bit Score: 70.83  E-value: 1.10e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 213417964    84 SSAQPSLDERILRFLEANGP--HRALHIAKALGMTTaKEVNPLLYSMRNKHLLSYDG---QTWKIYHSR 147
Cdd:smart00550   1 SLTQDSLEEKILEFLENSGDetSTALQLAKNLGLPK-KEVNRVLYSLEKKGKVCKQGgtpPLWKLTDKA 68
 
Name Accession Description Interval E-value
Zalpha smart00550
Z-DNA-binding domain in adenosine deaminases; Helix-turn-helix-containing domain. Also known ...
 8-72 5.87e-17

Z-DNA-binding domain in adenosine deaminases; Helix-turn-helix-containing domain. Also known as Zab.


Pssm-ID: 128823  Cd Length: 68  Bit Score: 71.21  E-value: 5.87e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 213417964     8 LSTGDNLEQKILQVLSDDGGP-VKIGQLVKKCQVPKKTLNQVLYRLKKEDRVSSP--EPATWSIGGAA 72
Cdd:smart00550   1 SLTQDSLEEKILEFLENSGDEtSTALQLAKNLGLPKKEVNRVLYSLEKKGKVCKQggTPPLWKLTDKA 68
Zalpha smart00550
Z-DNA-binding domain in adenosine deaminases; Helix-turn-helix-containing domain. Also known ...
 84-147 1.10e-16

Z-DNA-binding domain in adenosine deaminases; Helix-turn-helix-containing domain. Also known as Zab.


Pssm-ID: 128823  Cd Length: 68  Bit Score: 70.83  E-value: 1.10e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 213417964    84 SSAQPSLDERILRFLEANGP--HRALHIAKALGMTTaKEVNPLLYSMRNKHLLSYDG---QTWKIYHSR 147
Cdd:smart00550   1 SLTQDSLEEKILEFLENSGDetSTALQLAKNLGLPK-KEVNRVLYSLEKKGKVCKQGgtpPLWKLTDKA 68
z-alpha pfam02295
Adenosine deaminase z-alpha domain; This family consists of the N-terminus and thus the ...
 13-68 6.18e-04

Adenosine deaminase z-alpha domain; This family consists of the N-terminus and thus the z-alpha domain of double-stranded RNA-specific adenosine deaminase (ADAR), an RNA- editing enzyme. The z-alpha domain is a Z-DNA binding domain, and binding of this region to B-DNA has been shown to be disfavoured by steric hindrance.


Pssm-ID: 280459  Cd Length: 67  Bit Score: 36.72  E-value: 6.18e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 213417964   13 NLEQKILQVL--SDDGGPVKIGQLVKKCQVPKKTLNQVLYRLKKEDRVSSPE--PATWSI 68
Cdd:pfam02295   4 ECAEKILELLenLGEGKAATAIALERGLSTPKREINRVLYDLERKGDVYREDgtPPRWFL 63
 
Name Accession Description Interval E-value
Zalpha smart00550
Z-DNA-binding domain in adenosine deaminases; Helix-turn-helix-containing domain. Also known ...
 8-72 5.87e-17

Z-DNA-binding domain in adenosine deaminases; Helix-turn-helix-containing domain. Also known as Zab.


Pssm-ID: 128823  Cd Length: 68  Bit Score: 71.21  E-value: 5.87e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 213417964     8 LSTGDNLEQKILQVLSDDGGP-VKIGQLVKKCQVPKKTLNQVLYRLKKEDRVSSP--EPATWSIGGAA 72
Cdd:smart00550   1 SLTQDSLEEKILEFLENSGDEtSTALQLAKNLGLPKKEVNRVLYSLEKKGKVCKQggTPPLWKLTDKA 68
Zalpha smart00550
Z-DNA-binding domain in adenosine deaminases; Helix-turn-helix-containing domain. Also known ...
 84-147 1.10e-16

Z-DNA-binding domain in adenosine deaminases; Helix-turn-helix-containing domain. Also known as Zab.


Pssm-ID: 128823  Cd Length: 68  Bit Score: 70.83  E-value: 1.10e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 213417964    84 SSAQPSLDERILRFLEANGP--HRALHIAKALGMTTaKEVNPLLYSMRNKHLLSYDG---QTWKIYHSR 147
Cdd:smart00550   1 SLTQDSLEEKILEFLENSGDetSTALQLAKNLGLPK-KEVNRVLYSLEKKGKVCKQGgtpPLWKLTDKA 68
z-alpha pfam02295
Adenosine deaminase z-alpha domain; This family consists of the N-terminus and thus the ...
 13-68 6.18e-04

Adenosine deaminase z-alpha domain; This family consists of the N-terminus and thus the z-alpha domain of double-stranded RNA-specific adenosine deaminase (ADAR), an RNA- editing enzyme. The z-alpha domain is a Z-DNA binding domain, and binding of this region to B-DNA has been shown to be disfavoured by steric hindrance.


Pssm-ID: 280459  Cd Length: 67  Bit Score: 36.72  E-value: 6.18e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 213417964   13 NLEQKILQVL--SDDGGPVKIGQLVKKCQVPKKTLNQVLYRLKKEDRVSSPE--PATWSI 68
Cdd:pfam02295   4 ECAEKILELLenLGEGKAATAIALERGLSTPKREINRVLYDLERKGDVYREDgtPPRWFL 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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