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Conserved domains on  [gi|213385283|ref|NP_001132963|]
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zinc finger protein 455 like 1 isoform 2 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
2-61 1.07e-31

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 115.77  E-value: 1.07e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385283     2 LSFWDVAIDFSPEEWECLEPVQWNLYRDVMLENYSNLVFLGLTFSKPFLVTFLEQRQGPW 61
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
131-424 9.57e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 9.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385283 131 DKPYKCKECHKSFSSRSSLFIHQKNHTDEKNFKCEECGR--SFYYPSMLKQHQRIHSGEKLYKC-GECGKAFYDPSFLKQ 207
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385283 208 HQRIFCVEKHSKYEECGKVFSS-------ALTLNQHKEIHTGEKPFQCGKCHKAFRHPSALRIHMTVHTGEK-------- 272
Cdd:COG5048  111 SSSSSNSNDNNLLSSHSLPPSSrdpqlpdLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSnlslliss 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385283 273 ----PYKCEECGRCYFSSLSLRRHQIIHSEDNSNKCEECGRC---FSSSSCLRRHQTIHSEDKTYKCDECGR--YYSSSF 343
Cdd:COG5048  191 nvstSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNsqlSPKSLLSQSPSSLSSSDSSSSASESPRssLPTASS 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385283 344 SLRRHQVIHSED-----NPYKCEECDKRFTYSASLQEHQ--TIHTGE--KPYKC--ENCHKAFRHHSSLRKHKIVHTGEK 412
Cdd:COG5048  271 QSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                        330
                 ....*....|..
gi 213385283 413 PYKCEECGRCFS 424
Cdd:COG5048  351 PAKEKLLNSSSK 362
SUF4-like super family cl41227
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 104-152 5.15e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


The actual alignment was detected with superfamily member cd20908:

Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 5.15e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 213385283 104 KPYkCEECGKALSSHKTLSIHQRLHTgdkpYKCKECHKSFSSRSSLFIH 152
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
2-61 1.07e-31

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 115.77  E-value: 1.07e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385283     2 LSFWDVAIDFSPEEWECLEPVQWNLYRDVMLENYSNLVFLGLTFSKPFLVTFLEQRQGPW 61
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 1-42 7.99e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.91  E-value: 7.99e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 213385283    1 MLSFWDVAIDFSPEEWECLEPVQWNLYRDVMLENYSNLVFLG 42
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 2-41 1.99e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 75.66  E-value: 1.99e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 213385283   2 LSFWDVAIDFSPEEWECLEPVQWNLYRDVMLENYSNLVFL 41
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
131-424 9.57e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 9.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385283 131 DKPYKCKECHKSFSSRSSLFIHQKNHTDEKNFKCEECGR--SFYYPSMLKQHQRIHSGEKLYKC-GECGKAFYDPSFLKQ 207
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385283 208 HQRIFCVEKHSKYEECGKVFSS-------ALTLNQHKEIHTGEKPFQCGKCHKAFRHPSALRIHMTVHTGEK-------- 272
Cdd:COG5048  111 SSSSSNSNDNNLLSSHSLPPSSrdpqlpdLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSnlslliss 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385283 273 ----PYKCEECGRCYFSSLSLRRHQIIHSEDNSNKCEECGRC---FSSSSCLRRHQTIHSEDKTYKCDECGR--YYSSSF 343
Cdd:COG5048  191 nvstSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNsqlSPKSLLSQSPSSLSSSDSSSSASESPRssLPTASS 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385283 344 SLRRHQVIHSED-----NPYKCEECDKRFTYSASLQEHQ--TIHTGE--KPYKC--ENCHKAFRHHSSLRKHKIVHTGEK 412
Cdd:COG5048  271 QSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                        330
                 ....*....|..
gi 213385283 413 PYKCEECGRCFS 424
Cdd:COG5048  351 PAKEKLLNSSSK 362
zf-H2C2_2 pfam13465
Zinc-finger double domain;
372-397 1.72e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.72e-03
                          10        20
                  ....*....|....*....|....*.
gi 213385283  372 SLQEHQTIHTGEKPYKCENCHKAFRH 397
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 132-184 4.24e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 4.24e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 213385283 132 KPYkCKECHKSFSSRSSLFIHQKNhtdeKNFKCEECGRSFYYPSMLKQH-QRIH 184
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKA----KHFKCHICHKKLYTAGGLAVHcLQVH 49
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 104-152 5.15e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 5.15e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 213385283 104 KPYkCEECGKALSSHKTLSIHQRLHTgdkpYKCKECHKSFSSRSSLFIH 152
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
2-61 1.07e-31

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 115.77  E-value: 1.07e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385283     2 LSFWDVAIDFSPEEWECLEPVQWNLYRDVMLENYSNLVFLGLTFSKPFLVTFLEQRQGPW 61
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 1-42 7.99e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.91  E-value: 7.99e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 213385283    1 MLSFWDVAIDFSPEEWECLEPVQWNLYRDVMLENYSNLVFLG 42
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 2-41 1.99e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 75.66  E-value: 1.99e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 213385283   2 LSFWDVAIDFSPEEWECLEPVQWNLYRDVMLENYSNLVFL 41
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
131-424 9.57e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 9.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385283 131 DKPYKCKECHKSFSSRSSLFIHQKNHTDEKNFKCEECGR--SFYYPSMLKQHQRIHSGEKLYKC-GECGKAFYDPSFLKQ 207
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385283 208 HQRIFCVEKHSKYEECGKVFSS-------ALTLNQHKEIHTGEKPFQCGKCHKAFRHPSALRIHMTVHTGEK-------- 272
Cdd:COG5048  111 SSSSSNSNDNNLLSSHSLPPSSrdpqlpdLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSnlslliss 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385283 273 ----PYKCEECGRCYFSSLSLRRHQIIHSEDNSNKCEECGRC---FSSSSCLRRHQTIHSEDKTYKCDECGR--YYSSSF 343
Cdd:COG5048  191 nvstSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNsqlSPKSLLSQSPSSLSSSDSSSSASESPRssLPTASS 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385283 344 SLRRHQVIHSED-----NPYKCEECDKRFTYSASLQEHQ--TIHTGE--KPYKC--ENCHKAFRHHSSLRKHKIVHTGEK 412
Cdd:COG5048  271 QSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                        330
                 ....*....|..
gi 213385283 413 PYKCEECGRCFS 424
Cdd:COG5048  351 PAKEKLLNSSSK 362
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
141-465 1.65e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 1.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385283 141 KSFSSRSSLFIHQKNHT------DEKNFKCEECGRSFYYPSMLKQHQRIHSGEKLYKCG--ECGKAFYDPSFLKQHQRIf 212
Cdd:COG5048    7 QSSSSNNSVLSSTPKSTlkslsnAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRT- 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385283 213 cVEKHSKYEECGKVFSSALTLNQHKEIHTGEKPFQCGKC-HKAFRHPSALRIHMTVHTGEKPYKCeECGRCYFSSLSLRr 291
Cdd:COG5048   86 -HHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDNNLLsSHSLPPSSRDPQLPDLLSISNLRNN-PLPGNNSSSVNTP- 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385283 292 hQIIHSEDNSNKCEECGRCFSSSSCLRRHQTIHSEDKTYKCDECGRYYSSSFSLrRHQVIHSEDNPYKCEECDKRFTYSA 371
Cdd:COG5048  163 -QSNSLHPPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSS-SDQNLENSSSSLPLTTNSQLSPKSL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385283 372 SLQEHQTIHTGEKPYKCENCHKAFRHHSSLRKHKIVHTGE-------KPYKCEECGRCFSRYSYLRRHQ--EIHSEGNPQ 442
Cdd:COG5048  241 LSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGESLK 320

                        330       340
                 ....*....|....*....|....*..
gi 213385283 443 TCVE----CGKTFLNVYRLTRHIKVHT 465
Cdd:COG5048  321 PFSCpyslCGKLFSRNDALKRHILLHT 347
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
104-444 8.33e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 8.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385283 104 KPYKCEECGKALSSHKTLSIHQRLHTGDKPYKC--KECHKSFSSRSSLFIHQKNHTDEKNFkcEECGRSFYYPSMLKQHQ 181
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSD--LNSKSLPLSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385283 182 RIHSG------EKLYKCGECGKAFY----DPSFLKQHQRIFCVEKHSKYEECGKVFSSALTLNQ---------------H 236
Cdd:COG5048  110 LSSSSsnsndnNLLSSHSLPPSSRDpqlpDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAnslskdpssnlslliS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385283 237 KEIHTGEKPFQCGKCHKAFRHPSALRIHMTVHTGEKPYKCEECGRCYFSSLSLRRHQIIHSEDNSNKCEECGRCF--SSS 314
Cdd:COG5048  190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSlpTAS 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385283 315 SCLRRHQTIHSEDKT-----YKCDECGRYYSSSFSLRRHQ--VIHS--EDNPYKCEE--CDKRFTYSASLQEHQTIHTGE 383
Cdd:COG5048  270 SQSSSPNESDSSSEKgfslpIKSKQCNISFSRSSPLTRHLrsVNHSgeSLKPFSCPYslCGKLFSRNDALKRHILLHTSI 349

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385283 384 KPYKC-------------ENCHKAFRHH------------------------SSLRKHKIVHTGEKP--YKCEECGRCFS 424
Cdd:COG5048  350 SPAKEkllnssskfspllNNEPPQSLQQykdlkndkksetlsnscirnfkrdSNLSLHIITHLSFRPynCKNPPCSKSFN 429

                        410       420
                 ....*....|....*....|
gi 213385283 425 RYSYLRRHQEIHSEGNPQTC 444
Cdd:COG5048  430 RHYNLIPHKKIHTNHAPLLC 449
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 326-405 5.37e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 5.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385283 326 EDKTYKCD--ECGRYYSSSFSLRRHQvIHSEDNPYKCEECDKrftysaslQEHQTIHTGEKPYKCENCHKAFRHHSSLRK 403
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM-LHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 213385283 404 HK 405
Cdd:COG5189  417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
372-397 1.72e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.72e-03
                          10        20
                  ....*....|....*....|....*.
gi 213385283  372 SLQEHQTIHTGEKPYKCENCHKAFRH 397
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 254-355 1.94e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 1.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385283 254 AFRHPSALRI----HMTVHTGEKPYKCE--ECGRCYFSSLSLRRHQiihsednsnKCEECGRCFSSSSCLRRHQTIHSED 327
Cdd:COG5189  326 KLAHGGERNIdtpsRMLKVKDGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKD 396

                         90       100
                 ....*....|....*....|....*...
gi 213385283 328 KTYKCDECGRYYSSSFSLRRHQViHSED 355
Cdd:COG5189  397 KPYRCEVCDKRYKNLNGLKYHRK-HSHD 423
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
141-434 1.96e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 1.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385283 141 KSFSSRSSLFIHQKNHTDEKNFKCEECGRSFYYPSMLKQHQrihsgeklykcgecgKAFYDPSFLKQHQRIFCVEKHSKy 220
Cdd:COG5048  178 KDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQ---------------NLENSSSSLPLTTNSQLSPKSLL- 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385283 221 eecgkvFSSALTLNQHKEIHTGEKPFQCGKCHKAFRHPSALRIHMTVHTG-EKPYKCEECGRCYFSSLSLRRHQ--IIHS 297
Cdd:COG5048  242 ------SQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHS 315

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385283 298 EDNSNKCEE----CGRCFSSSSCLRRHQTIHSEDKTYKCDECGRYYSSSFSL-------RRHQVIHSEDNPYKCE--ECD 364
Cdd:COG5048  316 GESLKPFSCpyslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLnneppqsLQQYKDLKNDKKSETLsnSCI 395

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 213385283 365 KRFTYSASLQEHQTIHTGEKPYKCEN--CHKAFRHHSSLRKHKIVHTGEKPYKCEECGRCFSRYSYLRRHQE 434
Cdd:COG5048  396 RNFKRDSNLSLHIITHLSFRPYNCKNppCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 382-432 2.65e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 2.65e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 213385283 382 GEKPYKCE--NCHKAFRHHSSLRKHK-------------------IVHTGEKPYKCEECGRCFSRYSYLRRH 432
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMlhghqnqklhenpspekmnIFSAKDKPYRCEVCDKRYKNLNGLKYH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
400-425 3.36e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.36e-03
                          10        20
                  ....*....|....*....|....*.
gi 213385283  400 SLRKHKIVHTGEKPYKCEECGRCFSR 425
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 132-184 4.24e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 4.24e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 213385283 132 KPYkCKECHKSFSSRSSLFIHQKNhtdeKNFKCEECGRSFYYPSMLKQH-QRIH 184
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKA----KHFKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
121-145 4.61e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.61e-03
                          10        20
                  ....*....|....*....|....*
gi 213385283  121 LSIHQRLHTGDKPYKCKECHKSFSS 145
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 104-152 5.15e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 5.15e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 213385283 104 KPYkCEECGKALSSHKTLSIHQRLHTgdkpYKCKECHKSFSSRSSLFIH 152
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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