NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|213385251|ref|NP_001132951|]
View 

alpha-2-macroglobulin-like precursor [Danio rerio]

Protein Classification

Ig-like domain-containing alpha-2-macroglobulin family protein; alpha-2-macroglobulin family protein( domain architecture ID 13392302)

bacterial immunoglobulin (Ig)-like domain-containing alpha-2-macroglobulin family protein may be a broad-spectrum protease inhibitor, similar to uncharacterized conserved protein YfaS| alpha-2-macroglobulin family protein with a PAN/APPLE-like domain, with similarity to alpha-2-macroglobulin, a multidomain membrane-anchored pan-peptidase inhibitor that provides protection to the cell by trapping external proteases through a covalent interaction with an activated thioester

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
A2M_2 cd02897
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ...
948-1234 4.73e-147

Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.


:

Pssm-ID: 239227  Cd Length: 292  Bit Score: 448.95  E-value: 4.73e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  948 ALQNLHGLLRMPYGCGEQNMAVLSPNIYILQYLENTKQLTSAIREKASSFLKSGYQRQLNYKHFDGAYSTFGYGD--GNT 1025
Cdd:cd02897     1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDksGST 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251 1026 WLTAFVLRSFGKAQKYTFIDPQIIQSAKDWLISRRDSDGCFIQQGRLFNNRMKGGVNDNVTMTAYITASLLELETPVTDP 1105
Cdd:cd02897    81 WLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSERP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251 1106 VITKGLSCLRSVIEEVKNTYTTALLAYTFSLArDTNTRQQLFNKLEDLAISDGPLVHWSRSASADD-------SASLDVE 1178
Cdd:cd02897   161 VVEKALSCLEAALDSISDPYTLALAAYALTLA-GSEKRPEALKKLDELAISEDGTKHWSRPPPSEEgpsyywqAPSAEVE 239
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 213385251 1179 ISSYVLLAVLTADSlttADLGFANRIVSWLVKQQNAYGGFSSTQDTVVALQALSLY 1234
Cdd:cd02897   240 MTAYALLALLSAGG---EDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
YfaS super family cl34462
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ...
128-1386 9.92e-43

Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];


The actual alignment was detected with superfamily member COG2373:

Pssm-ID: 441940 [Multi-domain]  Cd Length: 1605  Bit Score: 171.80  E-value: 9.92e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  128 FIQTDKPIYMPGQIVNFRVVTMD-TNFAPVDQQYSIIVLeDSQDNRIGQWTNVSSTRWILQRSYELNPECREGAYKLKAF 206
Cdd:COG2373   372 FLFTDRGIYRPGETVHLKALLRDaDGKAPAGLPLTLELT-DPDGKEVRRQTLTLNEFGGYSFSFPLPEDAPTGTWRLELY 450
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  207 IGERMS--SHYFQVKKYVLPKFEVTVKKPKTVSVVEEELLIEVCAKYTYGQPVPGK--SW---VKVCRNPLP----YIIF 275
Cdd:COG2373   451 VDPKPAlgSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAAGLkvEGevtLRPARTAFPgypgYRFG 530
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  276 FPLCLEETLEI----TKT---GCAIHNFGLSMILN--STLKdnlkdsLHVEAVVTEE-GTEITMTKSESVHL-TYEIGki 344
Cdd:COG2373   531 DPDEEFEPEELdlgeGTLdadGKASLSLPLPDAPDapGPLR------ATVEASVFESgGRPVTRSATVPVHPaDFYVG-- 602
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  345 tlIDLPK--TYEPGSVIEGKIKLSDFKDAPIPNKEV-------------YLLEGENWSS------KLLLN--LTTDSDGL 401
Cdd:COG2373   603 --IRLPLfdGDPEGAPATFEVVAVDPDGKPVAGKGLkvelyreewryvwYKSDDGGWRYesqekeEPVAEgtLTTGADGP 680
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  402 ASFSLNTSS-----LSKKDISliANVYPDTRYYGYKTPYFSTDKKTvQLfriatvysptlseliiedieqplkcgtEITA 476
Cdd:COG2373   681 ASLSLTPVEwgryrLEVKDPD--GGLATSVRFYAGGNASWGAERPD-RL---------------------------ELSL 730
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  477 TVKYYFVGETVE-----DFSTDIVYMVLSRGVIVHhgfEKVEVKSSSNglasgtmSFKLSVGADVAPVVQILAYCVLP-S 550
Cdd:COG2373   731 DKESYKPGETAKlliqsPFAGRALVTVERDGVLET---QWVDVKGGGT-------TVEIPVTEDWAPNAYVSATLVRPgD 800
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  551 ENVIAANKRLdtekcFGN------------KVSLQfSPAKAVPGEKNTLQLSAQPGSlcG------LSAVDQSVLILESG 612
Cdd:COG2373   801 STANDMPARA-----YGVaplpvdpparrlKVELT-APEKLRPGETLTVTVKVKGAA--GkaaevtLAAVDEGILNLTGY 872
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  613 KRLDADKIFNllpvqsvSYYPYSVEdeqaclyvrprrsvltdnTYETLKSVGLKMATNLAVrvpdcLSYRGLTyhknlvm 692
Cdd:COG2373   873 KTPDPLDFFY-------GKRALGVE------------------TRDLYGRLIGAFGGAAGA-----LRSGGDG------- 915
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  693 ypdhrpvpvmfALGMAGVDGPVgnspsvtiRTVFPETWIWE-LAEVGDSGSAEVPVTVPDTITTWETEAFCLSSTGLGLA 771
Cdd:COG2373   916 -----------ALGRGGNPKPP--------RKRFKPVALFSgPVKTDADGKATVSFDLPDFNGTLRVMAVAWSDDRFGSA 976
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  772 PpAQLTVFQPFFLELSLPYSIIRGEIFELKATVFNYLSKCIMVKVSPAPSSDYTLKASSDDQYSscLCANGRKTFKWILT 851
Cdd:COG2373   977 E-ATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGGLTLEGEATQTVT--LAAGGRATVRFPLK 1053
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  852 PSVLGVVNVTVSAEAE---ASQTVcdneivsvpergRIDIVTRSLLVqaegiekTETNSWLLCPKGdslSEKVDLTLPKD 928
Cdd:COG2373  1054 APDAGDAKVTVTATGGgesDAREV------------ELPVRPANPLV-------TRATSGVLAPGE---SWTLPLDLPGG 1111
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  929 VIEGSAKSSVSVIGDILGRALQNLHGLLRMPYGCGEQNMAVLSPNIYILQyLENTKQLTSAIREKASSFLKSGYQRQLNY 1008
Cdd:COG2373  1112 LRPGTGSLTLSLSSSPPLDLAGLLRYLLRYPYGCTEQTTSRALPLLYLSD-LAEALGLKGDKDAELRARIQAAIARLLSM 1190
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251 1009 KHFDGAYSTF-GYGDGNTWLTAFVLRSFGKAQKYTF-IDPQIIQSAKDWLISR-RDSDGCFIQQGRLFNNRmkggvndnv 1085
Cdd:COG2373  1191 QNSDGGFGLWpGGSESDPWLTAYATDFLLEAREAGYaVPDDALDRALDYLRNYlRNPWEIEYDDAYRLAVR--------- 1261
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251 1086 tmtAYITASLLELETPVTDPvitkgLSCLRSVIEEVKNTYTTALLAYTFSLARDTNTRQQLFNKLEDLAISDGPLVHWSR 1165
Cdd:COG2373  1262 ---AYALYVLARAGKADLGD-----LRYLYDRRKDALSPLAKAQLAAALALLGDKARAEELLAAALARLRETGARDYWYG 1333
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251 1166 SASAD--DSAsldveissyvllAVLTADSLTTADLGFANRIVSWLVKQQNAyGGFSSTQDTVVALQALSLYATKvFSSDG 1243
Cdd:COG2373  1334 DYGSPlrDQA------------LALALLAELGPDAPLAPKLARWLAKALKS-GRWLSTQETAWALLALAAYARA-AGASP 1399
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251 1244 SSTVTVQSAGDSHHFDVNQD-NKLLYQEKQLAnvPGKYSIEVKGSACVSVQIAQFY---NIPTPTEAKTLSID------- 1312
Cdd:COG2373  1400 DFTATLTLDGKTLPLTGRGPlARVTLPAAELL--AGPLTITNTGDGPLYYTLTLSGypaEGPPPAASNGLEIErryydld 1477
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251 1313 -AKIEGDCEALGQNFIFDFTVKYDGPEEkTNMAIVDIkLLSGFTADTSALGTSSGTYV-----SLVERVDSKDDHVIVYL 1386
Cdd:COG2373  1478 gKPIDPASLKQGDLVVVRLTVTAPSGRV-ENVAVVDP-LPAGFEIENPRLATSGDLGDwlgdsWQPDHQEFRDDRVVAAF 1555
 
Name Accession Description Interval E-value
A2M_2 cd02897
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ...
948-1234 4.73e-147

Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.


Pssm-ID: 239227  Cd Length: 292  Bit Score: 448.95  E-value: 4.73e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  948 ALQNLHGLLRMPYGCGEQNMAVLSPNIYILQYLENTKQLTSAIREKASSFLKSGYQRQLNYKHFDGAYSTFGYGD--GNT 1025
Cdd:cd02897     1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDksGST 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251 1026 WLTAFVLRSFGKAQKYTFIDPQIIQSAKDWLISRRDSDGCFIQQGRLFNNRMKGGVNDNVTMTAYITASLLELETPVTDP 1105
Cdd:cd02897    81 WLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSERP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251 1106 VITKGLSCLRSVIEEVKNTYTTALLAYTFSLArDTNTRQQLFNKLEDLAISDGPLVHWSRSASADD-------SASLDVE 1178
Cdd:cd02897   161 VVEKALSCLEAALDSISDPYTLALAAYALTLA-GSEKRPEALKKLDELAISEDGTKHWSRPPPSEEgpsyywqAPSAEVE 239
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 213385251 1179 ISSYVLLAVLTADSlttADLGFANRIVSWLVKQQNAYGGFSSTQDTVVALQALSLY 1234
Cdd:cd02897   240 MTAYALLALLSAGG---EDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
TED_complement pfam07678
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ...
938-1234 5.96e-123

A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.


Pssm-ID: 462227 [Multi-domain]  Cd Length: 311  Bit Score: 385.50  E-value: 5.96e-123
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251   938 VSVIGDILGRALQ----NLHGLLRMPYGCGEQNMAVLSPNIYILQYLENTKQLTSAIREKASSFLKSGYQRQLNYKHFDG 1013
Cdd:pfam07678    1 ISVVGDIMGPAIQvvpeNLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  1014 AYSTFGYGDGNTWLTAFVLRSFGKAQKYTFIDPQIIQSAKDWLISRRDSDGCFIQQGRLFNNRMKGGVNDNVTMTAYITA 1093
Cdd:pfam07678   81 SYSAFGHSPGSTWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKGGVDGEVSLTAYVTI 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  1094 SLLELET-----PVTDPVITKGLSCLRS-VIEEVKNTYTTALLAYTFSLARDTNTRQQLFNKLEDLAISDGPLVHWSRSA 1167
Cdd:pfam07678  161 ALLEALDingllQRVHPSIRKALTYLEQaQLAGLTSPYTLAILAYALALAGSPETREELLKSLDAMAREEGNSRYWERDE 240
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 213385251  1168 SADDSA---------SLDVEISSYVLLAvltadSLTTADLGFANRIVSWLVKQQNAYGGFSSTQDTVVALQALSLY 1234
Cdd:pfam07678  241 KSDPQGvpeyppqapSLEVETTAYALLA-----YLLLGDLTYADPIVKWLTSQRNSHGGFSSTQDTVVALQALAEY 311
YfaS COG2373
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ...
128-1386 9.92e-43

Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];


Pssm-ID: 441940 [Multi-domain]  Cd Length: 1605  Bit Score: 171.80  E-value: 9.92e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  128 FIQTDKPIYMPGQIVNFRVVTMD-TNFAPVDQQYSIIVLeDSQDNRIGQWTNVSSTRWILQRSYELNPECREGAYKLKAF 206
Cdd:COG2373   372 FLFTDRGIYRPGETVHLKALLRDaDGKAPAGLPLTLELT-DPDGKEVRRQTLTLNEFGGYSFSFPLPEDAPTGTWRLELY 450
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  207 IGERMS--SHYFQVKKYVLPKFEVTVKKPKTVSVVEEELLIEVCAKYTYGQPVPGK--SW---VKVCRNPLP----YIIF 275
Cdd:COG2373   451 VDPKPAlgSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAAGLkvEGevtLRPARTAFPgypgYRFG 530
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  276 FPLCLEETLEI----TKT---GCAIHNFGLSMILN--STLKdnlkdsLHVEAVVTEE-GTEITMTKSESVHL-TYEIGki 344
Cdd:COG2373   531 DPDEEFEPEELdlgeGTLdadGKASLSLPLPDAPDapGPLR------ATVEASVFESgGRPVTRSATVPVHPaDFYVG-- 602
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  345 tlIDLPK--TYEPGSVIEGKIKLSDFKDAPIPNKEV-------------YLLEGENWSS------KLLLN--LTTDSDGL 401
Cdd:COG2373   603 --IRLPLfdGDPEGAPATFEVVAVDPDGKPVAGKGLkvelyreewryvwYKSDDGGWRYesqekeEPVAEgtLTTGADGP 680
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  402 ASFSLNTSS-----LSKKDISliANVYPDTRYYGYKTPYFSTDKKTvQLfriatvysptlseliiedieqplkcgtEITA 476
Cdd:COG2373   681 ASLSLTPVEwgryrLEVKDPD--GGLATSVRFYAGGNASWGAERPD-RL---------------------------ELSL 730
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  477 TVKYYFVGETVE-----DFSTDIVYMVLSRGVIVHhgfEKVEVKSSSNglasgtmSFKLSVGADVAPVVQILAYCVLP-S 550
Cdd:COG2373   731 DKESYKPGETAKlliqsPFAGRALVTVERDGVLET---QWVDVKGGGT-------TVEIPVTEDWAPNAYVSATLVRPgD 800
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  551 ENVIAANKRLdtekcFGN------------KVSLQfSPAKAVPGEKNTLQLSAQPGSlcG------LSAVDQSVLILESG 612
Cdd:COG2373   801 STANDMPARA-----YGVaplpvdpparrlKVELT-APEKLRPGETLTVTVKVKGAA--GkaaevtLAAVDEGILNLTGY 872
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  613 KRLDADKIFNllpvqsvSYYPYSVEdeqaclyvrprrsvltdnTYETLKSVGLKMATNLAVrvpdcLSYRGLTyhknlvm 692
Cdd:COG2373   873 KTPDPLDFFY-------GKRALGVE------------------TRDLYGRLIGAFGGAAGA-----LRSGGDG------- 915
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  693 ypdhrpvpvmfALGMAGVDGPVgnspsvtiRTVFPETWIWE-LAEVGDSGSAEVPVTVPDTITTWETEAFCLSSTGLGLA 771
Cdd:COG2373   916 -----------ALGRGGNPKPP--------RKRFKPVALFSgPVKTDADGKATVSFDLPDFNGTLRVMAVAWSDDRFGSA 976
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  772 PpAQLTVFQPFFLELSLPYSIIRGEIFELKATVFNYLSKCIMVKVSPAPSSDYTLKASSDDQYSscLCANGRKTFKWILT 851
Cdd:COG2373   977 E-ATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGGLTLEGEATQTVT--LAAGGRATVRFPLK 1053
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  852 PSVLGVVNVTVSAEAE---ASQTVcdneivsvpergRIDIVTRSLLVqaegiekTETNSWLLCPKGdslSEKVDLTLPKD 928
Cdd:COG2373  1054 APDAGDAKVTVTATGGgesDAREV------------ELPVRPANPLV-------TRATSGVLAPGE---SWTLPLDLPGG 1111
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  929 VIEGSAKSSVSVIGDILGRALQNLHGLLRMPYGCGEQNMAVLSPNIYILQyLENTKQLTSAIREKASSFLKSGYQRQLNY 1008
Cdd:COG2373  1112 LRPGTGSLTLSLSSSPPLDLAGLLRYLLRYPYGCTEQTTSRALPLLYLSD-LAEALGLKGDKDAELRARIQAAIARLLSM 1190
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251 1009 KHFDGAYSTF-GYGDGNTWLTAFVLRSFGKAQKYTF-IDPQIIQSAKDWLISR-RDSDGCFIQQGRLFNNRmkggvndnv 1085
Cdd:COG2373  1191 QNSDGGFGLWpGGSESDPWLTAYATDFLLEAREAGYaVPDDALDRALDYLRNYlRNPWEIEYDDAYRLAVR--------- 1261
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251 1086 tmtAYITASLLELETPVTDPvitkgLSCLRSVIEEVKNTYTTALLAYTFSLARDTNTRQQLFNKLEDLAISDGPLVHWSR 1165
Cdd:COG2373  1262 ---AYALYVLARAGKADLGD-----LRYLYDRRKDALSPLAKAQLAAALALLGDKARAEELLAAALARLRETGARDYWYG 1333
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251 1166 SASAD--DSAsldveissyvllAVLTADSLTTADLGFANRIVSWLVKQQNAyGGFSSTQDTVVALQALSLYATKvFSSDG 1243
Cdd:COG2373  1334 DYGSPlrDQA------------LALALLAELGPDAPLAPKLARWLAKALKS-GRWLSTQETAWALLALAAYARA-AGASP 1399
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251 1244 SSTVTVQSAGDSHHFDVNQD-NKLLYQEKQLAnvPGKYSIEVKGSACVSVQIAQFY---NIPTPTEAKTLSID------- 1312
Cdd:COG2373  1400 DFTATLTLDGKTLPLTGRGPlARVTLPAAELL--AGPLTITNTGDGPLYYTLTLSGypaEGPPPAASNGLEIErryydld 1477
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251 1313 -AKIEGDCEALGQNFIFDFTVKYDGPEEkTNMAIVDIkLLSGFTADTSALGTSSGTYV-----SLVERVDSKDDHVIVYL 1386
Cdd:COG2373  1478 gKPIDPASLKQGDLVVVRLTVTAPSGRV-ENVAVVDP-LPAGFEIENPRLATSGDLGDwlgdsWQPDHQEFRDDRVVAAF 1555
A2M pfam00207
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ...
729-817 1.20e-41

Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.


Pssm-ID: 459711 [Multi-domain]  Cd Length: 91  Bit Score: 147.73  E-value: 1.20e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251   729 TWIWELAEVGDSGSAEVPVTVPDTITTWETEAFCLS-STGLGLAPPAQLTVFQPFFLELSLPYSIIRGEIFELKATVFNY 807
Cdd:pfam00207    1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSpDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80
                           90
                   ....*....|
gi 213385251   808 LSKCIMVKVS 817
Cdd:pfam00207   81 LDKCLKVRVR 90
 
Name Accession Description Interval E-value
A2M_2 cd02897
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ...
948-1234 4.73e-147

Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.


Pssm-ID: 239227  Cd Length: 292  Bit Score: 448.95  E-value: 4.73e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  948 ALQNLHGLLRMPYGCGEQNMAVLSPNIYILQYLENTKQLTSAIREKASSFLKSGYQRQLNYKHFDGAYSTFGYGD--GNT 1025
Cdd:cd02897     1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDksGST 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251 1026 WLTAFVLRSFGKAQKYTFIDPQIIQSAKDWLISRRDSDGCFIQQGRLFNNRMKGGVNDNVTMTAYITASLLELETPVTDP 1105
Cdd:cd02897    81 WLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSERP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251 1106 VITKGLSCLRSVIEEVKNTYTTALLAYTFSLArDTNTRQQLFNKLEDLAISDGPLVHWSRSASADD-------SASLDVE 1178
Cdd:cd02897   161 VVEKALSCLEAALDSISDPYTLALAAYALTLA-GSEKRPEALKKLDELAISEDGTKHWSRPPPSEEgpsyywqAPSAEVE 239
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 213385251 1179 ISSYVLLAVLTADSlttADLGFANRIVSWLVKQQNAYGGFSSTQDTVVALQALSLY 1234
Cdd:cd02897   240 MTAYALLALLSAGG---EDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
TED_complement pfam07678
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ...
938-1234 5.96e-123

A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.


Pssm-ID: 462227 [Multi-domain]  Cd Length: 311  Bit Score: 385.50  E-value: 5.96e-123
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251   938 VSVIGDILGRALQ----NLHGLLRMPYGCGEQNMAVLSPNIYILQYLENTKQLTSAIREKASSFLKSGYQRQLNYKHFDG 1013
Cdd:pfam07678    1 ISVVGDIMGPAIQvvpeNLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  1014 AYSTFGYGDGNTWLTAFVLRSFGKAQKYTFIDPQIIQSAKDWLISRRDSDGCFIQQGRLFNNRMKGGVNDNVTMTAYITA 1093
Cdd:pfam07678   81 SYSAFGHSPGSTWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKGGVDGEVSLTAYVTI 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  1094 SLLELET-----PVTDPVITKGLSCLRS-VIEEVKNTYTTALLAYTFSLARDTNTRQQLFNKLEDLAISDGPLVHWSRSA 1167
Cdd:pfam07678  161 ALLEALDingllQRVHPSIRKALTYLEQaQLAGLTSPYTLAILAYALALAGSPETREELLKSLDAMAREEGNSRYWERDE 240
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 213385251  1168 SADDSA---------SLDVEISSYVLLAvltadSLTTADLGFANRIVSWLVKQQNAYGGFSSTQDTVVALQALSLY 1234
Cdd:pfam07678  241 KSDPQGvpeyppqapSLEVETTAYALLA-----YLLLGDLTYADPIVKWLTSQRNSHGGFSSTQDTVVALQALAEY 311
A2M_like cd02891
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier ...
948-1234 7.99e-108

Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. This group contains another broadly specific proteinase inhibitor: pregnancy zone protein (PZP). PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. This group also contains C3, C4 and C5 of vertebrate complement. The vertebrate complement is an effector of both the acquired and innate immune systems The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.


Pssm-ID: 239221 [Multi-domain]  Cd Length: 282  Bit Score: 342.83  E-value: 7.99e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  948 ALQNLHGLLRMPYGCGEQNMAVLSPNIYILQYLENTKQLTSAIREKASSFLKSGYQRQLNYKHFDGAYSTFG-YGDGNTW 1026
Cdd:cd02891     1 SLGNLDYLLRYPYGCGEQTMSRAAPNLYVLKYLDATGQLTPEIREKALEYIRKGYQRLLTYQRSDGSFSAWGnSDSGSTW 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251 1027 LTAFVLRSFGKAQKYTFIDPQIIQSAKDWLISRRDSDGCFIQQGRLFNNRMKGGVNDNVTMTAYITASLLELETPVtDPV 1106
Cdd:cd02891    81 LTAYVVKFLSQARKYIDVDENVLARALGWLVPQQKEDGSFRELGPVIHREMKGGVDDSVSLTAYVLIALAEAGKAC-DAS 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251 1107 ITKGLSCLRSVIEEVKNTYTTALLAYTFSLARDTNTRQQLFNKLEDLAISDGPLVHWSRSASADDSASLDVEISSYVLLA 1186
Cdd:cd02891   160 IEKALAYLETQLDGLLDPYALAILAYALALAGDSTRADEALKKLLEAAREKGGTAHWSLSWPGDYGSSLRVEATAYALLA 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 213385251 1187 VLTADslttaDLGFANRIVSWLVKQQNAYGGFSSTQDTVVALQALSLY 1234
Cdd:cd02891   240 LLKLG-----DLEEAGPIAKWLAQQRNSGGGFLSTQDTVVALQALAAY 282
complement_C3_C4_C5 cd02896
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, ...
951-1234 9.00e-77

Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.


Pssm-ID: 239226 [Multi-domain]  Cd Length: 297  Bit Score: 256.43  E-value: 9.00e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  951 NLHGLLRMPYGCGEQNMAVLSPNIYILQYLENTKQ---LTSAIREKASSFLKSGYQRQLNYKHFDGAYSTFGYGDGNTWL 1027
Cdd:cd02896     4 GLEKLIRLPTGCGEQTMIKLAPTVYALRYLDTTNQwekLGPERRDEALKYIRQGYQRQLSYRKPDGSYAAWKNRPSSTWL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251 1028 TAFVLRSFGKAQKYTFIDPQIIQSAKDWLISRRDSDGCFIQQGRLFNNRMKGGVNDN---VTMTAYITASLLE----LET 1100
Cdd:cd02896    84 TAFVVKVFSLARKYIPVDQNVICGSVNWLISNQKPDGSFQEPSPVIHREMTGGVEGSegdVSLTAFVLIALQEarsiCPP 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251 1101 PVT--DPVITKGLSCLRSVIEEVKNTYTTALLAYTFSLArDTNTRQQLFNKLEDLAISDGPLVHWSRSASADD----SAS 1174
Cdd:cd02896   164 EVQnlDQSIRKAISYLENQLPNLQRPYALAITAYALALA-DSPLSHAANRKLLSLAKRDGNGWYWWTIDSPYWpvpgPSA 242
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251 1175 LDVEISSYVLLAvltadSLTTADLGFANRIVSWLVKQQNAYGGFSSTQDTVVALQALSLY 1234
Cdd:cd02896   243 ITVETTAYALLA-----LLKLGDIEYANPIARWLTEQRNYGGGFGSTQDTVVALQALAEY 297
ISOPREN_C2_like cd00688
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ...
948-1234 4.14e-65

This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.


Pssm-ID: 238362 [Multi-domain]  Cd Length: 300  Bit Score: 223.20  E-value: 4.14e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  948 ALQNLHGLLRMPYG--------CGEQNMAVLSPNIYILQYLENTKqltsaIREKASSFLKSGYQRQLNYKHFDGAYSTF- 1018
Cdd:cd00688     1 IEKHLKYLLRYPYGdghwyqslCGEQTWSTAWPLLALLLLLAATG-----IRDKADENIEKGIQRLLSYQLSDGGFSGWg 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251 1019 GYGDGNTWLTAFVLRSFGKAQKYTFIDPQIIQSAKDWLISRRDSDGCFIQQGRLFNNrmKGGVNDNVTMTAYITASLLEL 1098
Cdd:cd00688    76 GNDYPSLWLTAYALKALLLAGDYIAVDRIDLARALNWLLSLQNEDGGFREDGPGNHR--IGGDESDVRLTAYALIALALL 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251 1099 ETPVTDPVITKGLSCLRSVIEE--------VKNTYTTALLAYTFSLARDTN--TRQQLFNKLEDLAISDGPLVHWsRSAS 1168
Cdd:cd00688   154 GKLDPDPLIEKALDYLLSCQNYdggfgpggESHGYGTACAAAALALLGDLDspDAKKALRWLLSRQRPDGGWGEG-RDRT 232
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 213385251 1169 ADDSASLDVEISSYVLLAVLTADslttaDLGFANRIVSWLVKQQNAYGGFSS-------TQDTVVALQALSLY 1234
Cdd:cd00688   233 NKLSDSCYTEWAAYALLALGKLG-----DLEDAEKLVKWLLSQQNEDGGFSSkpgksydTQHTVFALLALSLY 300
YfaS COG2373
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ...
128-1386 9.92e-43

Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];


Pssm-ID: 441940 [Multi-domain]  Cd Length: 1605  Bit Score: 171.80  E-value: 9.92e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  128 FIQTDKPIYMPGQIVNFRVVTMD-TNFAPVDQQYSIIVLeDSQDNRIGQWTNVSSTRWILQRSYELNPECREGAYKLKAF 206
Cdd:COG2373   372 FLFTDRGIYRPGETVHLKALLRDaDGKAPAGLPLTLELT-DPDGKEVRRQTLTLNEFGGYSFSFPLPEDAPTGTWRLELY 450
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  207 IGERMS--SHYFQVKKYVLPKFEVTVKKPKTVSVVEEELLIEVCAKYTYGQPVPGK--SW---VKVCRNPLP----YIIF 275
Cdd:COG2373   451 VDPKPAlgSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAAGLkvEGevtLRPARTAFPgypgYRFG 530
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  276 FPLCLEETLEI----TKT---GCAIHNFGLSMILN--STLKdnlkdsLHVEAVVTEE-GTEITMTKSESVHL-TYEIGki 344
Cdd:COG2373   531 DPDEEFEPEELdlgeGTLdadGKASLSLPLPDAPDapGPLR------ATVEASVFESgGRPVTRSATVPVHPaDFYVG-- 602
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  345 tlIDLPK--TYEPGSVIEGKIKLSDFKDAPIPNKEV-------------YLLEGENWSS------KLLLN--LTTDSDGL 401
Cdd:COG2373   603 --IRLPLfdGDPEGAPATFEVVAVDPDGKPVAGKGLkvelyreewryvwYKSDDGGWRYesqekeEPVAEgtLTTGADGP 680
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  402 ASFSLNTSS-----LSKKDISliANVYPDTRYYGYKTPYFSTDKKTvQLfriatvysptlseliiedieqplkcgtEITA 476
Cdd:COG2373   681 ASLSLTPVEwgryrLEVKDPD--GGLATSVRFYAGGNASWGAERPD-RL---------------------------ELSL 730
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  477 TVKYYFVGETVE-----DFSTDIVYMVLSRGVIVHhgfEKVEVKSSSNglasgtmSFKLSVGADVAPVVQILAYCVLP-S 550
Cdd:COG2373   731 DKESYKPGETAKlliqsPFAGRALVTVERDGVLET---QWVDVKGGGT-------TVEIPVTEDWAPNAYVSATLVRPgD 800
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  551 ENVIAANKRLdtekcFGN------------KVSLQfSPAKAVPGEKNTLQLSAQPGSlcG------LSAVDQSVLILESG 612
Cdd:COG2373   801 STANDMPARA-----YGVaplpvdpparrlKVELT-APEKLRPGETLTVTVKVKGAA--GkaaevtLAAVDEGILNLTGY 872
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  613 KRLDADKIFNllpvqsvSYYPYSVEdeqaclyvrprrsvltdnTYETLKSVGLKMATNLAVrvpdcLSYRGLTyhknlvm 692
Cdd:COG2373   873 KTPDPLDFFY-------GKRALGVE------------------TRDLYGRLIGAFGGAAGA-----LRSGGDG------- 915
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  693 ypdhrpvpvmfALGMAGVDGPVgnspsvtiRTVFPETWIWE-LAEVGDSGSAEVPVTVPDTITTWETEAFCLSSTGLGLA 771
Cdd:COG2373   916 -----------ALGRGGNPKPP--------RKRFKPVALFSgPVKTDADGKATVSFDLPDFNGTLRVMAVAWSDDRFGSA 976
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  772 PpAQLTVFQPFFLELSLPYSIIRGEIFELKATVFNYLSKCIMVKVSPAPSSDYTLKASSDDQYSscLCANGRKTFKWILT 851
Cdd:COG2373   977 E-ATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGGLTLEGEATQTVT--LAAGGRATVRFPLK 1053
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  852 PSVLGVVNVTVSAEAE---ASQTVcdneivsvpergRIDIVTRSLLVqaegiekTETNSWLLCPKGdslSEKVDLTLPKD 928
Cdd:COG2373  1054 APDAGDAKVTVTATGGgesDAREV------------ELPVRPANPLV-------TRATSGVLAPGE---SWTLPLDLPGG 1111
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  929 VIEGSAKSSVSVIGDILGRALQNLHGLLRMPYGCGEQNMAVLSPNIYILQyLENTKQLTSAIREKASSFLKSGYQRQLNY 1008
Cdd:COG2373  1112 LRPGTGSLTLSLSSSPPLDLAGLLRYLLRYPYGCTEQTTSRALPLLYLSD-LAEALGLKGDKDAELRARIQAAIARLLSM 1190
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251 1009 KHFDGAYSTF-GYGDGNTWLTAFVLRSFGKAQKYTF-IDPQIIQSAKDWLISR-RDSDGCFIQQGRLFNNRmkggvndnv 1085
Cdd:COG2373  1191 QNSDGGFGLWpGGSESDPWLTAYATDFLLEAREAGYaVPDDALDRALDYLRNYlRNPWEIEYDDAYRLAVR--------- 1261
                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251 1086 tmtAYITASLLELETPVTDPvitkgLSCLRSVIEEVKNTYTTALLAYTFSLARDTNTRQQLFNKLEDLAISDGPLVHWSR 1165
Cdd:COG2373  1262 ---AYALYVLARAGKADLGD-----LRYLYDRRKDALSPLAKAQLAAALALLGDKARAEELLAAALARLRETGARDYWYG 1333
                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251 1166 SASAD--DSAsldveissyvllAVLTADSLTTADLGFANRIVSWLVKQQNAyGGFSSTQDTVVALQALSLYATKvFSSDG 1243
Cdd:COG2373  1334 DYGSPlrDQA------------LALALLAELGPDAPLAPKLARWLAKALKS-GRWLSTQETAWALLALAAYARA-AGASP 1399
                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251 1244 SSTVTVQSAGDSHHFDVNQD-NKLLYQEKQLAnvPGKYSIEVKGSACVSVQIAQFY---NIPTPTEAKTLSID------- 1312
Cdd:COG2373  1400 DFTATLTLDGKTLPLTGRGPlARVTLPAAELL--AGPLTITNTGDGPLYYTLTLSGypaEGPPPAASNGLEIErryydld 1477
                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251 1313 -AKIEGDCEALGQNFIFDFTVKYDGPEEkTNMAIVDIkLLSGFTADTSALGTSSGTYV-----SLVERVDSKDDHVIVYL 1386
Cdd:COG2373  1478 gKPIDPASLKQGDLVVVRLTVTAPSGRV-ENVAVVDP-LPAGFEIENPRLATSGDLGDwlgdsWQPDHQEFRDDRVVAAF 1555
A2M pfam00207
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ...
729-817 1.20e-41

Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.


Pssm-ID: 459711 [Multi-domain]  Cd Length: 91  Bit Score: 147.73  E-value: 1.20e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251   729 TWIWELAEVGDSGSAEVPVTVPDTITTWETEAFCLS-STGLGLAPPAQLTVFQPFFLELSLPYSIIRGEIFELKATVFNY 807
Cdd:pfam00207    1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSpDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80
                           90
                   ....*....|
gi 213385251   808 LSKCIMVKVS 817
Cdd:pfam00207   81 LDKCLKVRVR 90
A2M_BRD pfam07703
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ...
459-609 3.43e-29

Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognized as the Venus flytrap mechanism.


Pssm-ID: 462235 [Multi-domain]  Cd Length: 139  Bit Score: 113.98  E-value: 3.43e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251   459 LIIEDIEQPLKCGTEITATVKYYFVGETVEDFSTdivYMVLSRGVIVHHGfekvevksssngLASGTMSFKLSVGADVAP 538
Cdd:pfam07703    1 LHLSTDKTEYKPGETATVTVKSPFDGTVERDGFT---YLVLSKGQIVVVG------------RGGVTTSFSLPVTAEMAP 65
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 213385251   539 VVQILAYCV---LPSENVIAANKRLDTEKCFGNKVSLQFSPAKAVPGEKNTLQLSAQPGSLCGLSAVDQSVLIL 609
Cdd:pfam07703   66 SARVVAYYVrvdLSKPEVVADSVWVDVDDTCENKLKVTLSAEKYRPGSTVELKVKADPGAYVALAAVDKGVLLL 139
A2M_recep pfam07677
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ...
1339-1432 7.67e-28

A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.


Pssm-ID: 462226  Cd Length: 92  Bit Score: 108.43  E-value: 7.67e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251  1339 EKTNMAIVDIKLLSGFTADTSALGT-SSGTYVSLVERVDskDDHVIVYLKEISKNvAMNYQIQMKQVLQVKNLKPAVVKV 1417
Cdd:pfam07677    1 ESSNMAILEVGLPSGFVPDEEDLKKlGVDPLIKRVETVD--DGKVILYLDKLSGE-PLCFSFRAEQTFPVANLKPAPVKV 77
                           90
                   ....*....|....*
gi 213385251  1418 YDYYQTSDQSEIEYS 1432
Cdd:pfam07677   78 YDYYEPERRATTFYS 92
MG2 pfam01835
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ...
128-218 1.02e-19

MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.


Pssm-ID: 426464 [Multi-domain]  Cd Length: 95  Bit Score: 85.45  E-value: 1.02e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251   128 FIQTDKPIYMPGQIVNFRVVTMDTNFAPVDQQYSIIVLEDSQDNRIGQWTNVSSTRWILQRSYELNPECREGAYKLKAF- 206
Cdd:pfam01835    3 FVYTDRGIYRPGETVHFKGLLRDQDLRPLAGLPVTLTVTDPDGNEVRRLPLTTDEFGGFSGSFPLPETAPTGTYTVVLRd 82
                           90
                   ....*....|...
gi 213385251   207 -IGERMSSHYFQV 218
Cdd:pfam01835   83 gAGGSLGSGSFRV 95
MG3 pfam17791
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement ...
220-301 1.92e-19

Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement components C3, C4 and C5.


Pssm-ID: 465509  Cd Length: 83  Bit Score: 84.25  E-value: 1.92e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385251   220 KYVLPKFEVTVKKPKTVSVVEEELLIEVCAKYTYGQPVPGKSWVKVCRNplpYIIFFPLCLEETLEITKTGCAIHNFGLS 299
Cdd:pfam17791    1 EYVLPKFEVKVEVPKFISVKDEEFQVTICAKYTYGKPVKGKAYVTLCLK---DDSKRKCFESFSKELDKDGCGSASLSTE 77

                   ..
gi 213385251   300 MI 301
Cdd:pfam17791   78 EF 79
MG4 pfam17789
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins.
344-414 4.18e-09

Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins.


Pssm-ID: 465507  Cd Length: 95  Bit Score: 54.95  E-value: 4.18e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 213385251   344 ITLIDLPKTYEPGSVIEGKIKLSDFKDAPIPNKEVYLlegENWSSKLLLNLTTDSDGLASFSLNTSSLSKK 414
Cdd:pfam17789    1 ITFEKTPKYFKPGLPFSGQVLVVDPDGSPAPNVPVFI---EAGNTEFNQNLTTDEDGTAQFSINTPGNAAS 68
SVA pfam05326
Seminal vesicle autoantigen (SVA); This family consists of seminal vesicle autoantigen and ...
774-848 6.11e-04

Seminal vesicle autoantigen (SVA); This family consists of seminal vesicle autoantigen and prolactin-inducible (PIP) proteins. Seminal vesicle autoantigen (SVA) is specifically present in the seminal plasma of mice. This 19-kDa secretory glycoprotein suppresses the motility of spermatozoa by interacting with phospholipid. PIP, has several known functions. In saliva, this protein plays a role in host defence by binding to microorganizms such as Streptococcus. PIP is an aspartyl proteinase and it acts as a factor capable of suppressing T-cell apoptosis through its interaction with CD4.


Pssm-ID: 398804  Cd Length: 124  Bit Score: 41.23  E-value: 6.11e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 213385251   774 AQLTVFQPFFLELSLPYSIIRGEIFELKATVFNYLSKCIMVKVSPApsSDYTLKASSDDQYSSCLCANGRKTFKW 848
Cdd:pfam05326   26 GQDNRNKPLSLDLKVPSTAKKNNEVTVTLTVKTNVKECMVVKAYLE--SNPPIKGSFNYIYTACLCNDYPRTFFW 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH
HHS Vulnerability Disclosure