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Conserved domains on  [gi|212646632|ref|NP_001129916|]
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Two pore potassium channel protein sup-9 [Caenorhabditis elegans]

Protein Classification

potassium channel family protein( domain architecture ID 10545436)

potassium channel family protein spans the cell membrane to form a conduction pathway or pore, through which selective ions such as potassium, sodium, and calcium, translocate across cell membranes

Gene Ontology:  GO:0005267|GO:0034220|GO:0005216|GO:0071805|GO:0016020
PubMed:  15816170|9525859|11836519|11178249|1772658
SCOP:  4000034
TCDB:  1.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 99-155 7.73e-13

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


:

Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 62.67  E-value: 7.73e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 212646632   99 WTFGQAFFFAGTLISTVGYGRVSPRTEYGKLFTILYCVIGIPLTLALLSAIVARMRE 155
Cdd:pfam07885  22 WSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFLTE 78
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 189-265 1.98e-08

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


:

Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 50.73  E-value: 1.98e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 212646632  189 LLLFVFAIPAWVFSSIETDW--SYLDAFYYCFVSLTTIGLGDFEPGDDPNQSFrglykigATVYLMGGLCCMMLFLATL 265
Cdd:pfam07885   1 IVLLLVLIFGTVYYLLEEGWewSFLDALYFSFVTLTTVGYGDIVPLTDAGRLF-------TIFYILIGIPLFAIFLAVL 72
 
Name Accession Description Interval E-value
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 99-155 7.73e-13

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 62.67  E-value: 7.73e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 212646632   99 WTFGQAFFFAGTLISTVGYGRVSPRTEYGKLFTILYCVIGIPLTLALLSAIVARMRE 155
Cdd:pfam07885  22 WSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFLTE 78
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 189-265 1.98e-08

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 50.73  E-value: 1.98e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 212646632  189 LLLFVFAIPAWVFSSIETDW--SYLDAFYYCFVSLTTIGLGDFEPGDDPNQSFrglykigATVYLMGGLCCMMLFLATL 265
Cdd:pfam07885   1 IVLLLVLIFGTVYYLLEEGWewSFLDALYFSFVTLTTVGYGDIVPLTDAGRLF-------TIFYILIGIPLFAIFLAVL 72
PRK10537 PRK10537
voltage-gated potassium channel protein;
104-177 5.66e-04

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 41.16  E-value: 5.66e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 212646632 104 AFFFAGTLISTVGYGRVSPRTEYGKLFTILYCVIGIPLTLALLSAIVARMrePSHKLRGLLNQRLGHLFTVNHI 177
Cdd:PRK10537 172 AFYFSIVTMSTVGYGDIVPVSESARLFTISVIILGITVFATSISAIFGPV--IRGNLKRLVKGRISHMHRKDHF 243
 
Name Accession Description Interval E-value
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 99-155 7.73e-13

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 62.67  E-value: 7.73e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 212646632   99 WTFGQAFFFAGTLISTVGYGRVSPRTEYGKLFTILYCVIGIPLTLALLSAIVARMRE 155
Cdd:pfam07885  22 WSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFLTE 78
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 189-265 1.98e-08

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 50.73  E-value: 1.98e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 212646632  189 LLLFVFAIPAWVFSSIETDW--SYLDAFYYCFVSLTTIGLGDFEPGDDPNQSFrglykigATVYLMGGLCCMMLFLATL 265
Cdd:pfam07885   1 IVLLLVLIFGTVYYLLEEGWewSFLDALYFSFVTLTTVGYGDIVPLTDAGRLF-------TIFYILIGIPLFAIFLAVL 72
PRK10537 PRK10537
voltage-gated potassium channel protein;
104-177 5.66e-04

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 41.16  E-value: 5.66e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 212646632 104 AFFFAGTLISTVGYGRVSPRTEYGKLFTILYCVIGIPLTLALLSAIVARMrePSHKLRGLLNQRLGHLFTVNHI 177
Cdd:PRK10537 172 AFYFSIVTMSTVGYGDIVPVSESARLFTISVIILGITVFATSISAIFGPV--IRGNLKRLVKGRISHMHRKDHF 243
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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