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Conserved domains on  [gi|209915553|ref|NP_001129597|]
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G1/S-specific cyclin-D3 isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_CCND3_rpt2 cd20578
second cyclin box found in G1/S-specific cyclin-D3 (CCND3); CCND3 is a regulatory component of ...
 84-188 2.62e-73

second cyclin box found in G1/S-specific cyclin-D3 (CCND3); CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410281  Cd Length: 105  Bit Score: 217.24  E-value: 2.62e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209915553  84 IAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGT 163
Cdd:cd20578    1 IAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGT 80

                         90       100
                 ....*....|....*....|....*
gi 209915553 164 EVDCLRACQEQIEAALRESLREASQ 188
Cdd:cd20578   81 EVDCLRACQEQIEAALRESLREASQ 105
CYCLIN_SF super family cl40454
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 2-66 2.56e-44

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


The actual alignment was detected with superfamily member cd20575:

Pssm-ID: 477360  Cd Length: 150  Bit Score: 145.13  E-value: 2.56e-44
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 209915553   2 ELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLE 66
Cdd:cd20575    1 ELLCCEGTRRVPRAGPDPRLLGDQRVLQNLLRLEERYVPRVSYFQCVQREIKPYMRKMLAYWMLE 65
 
Name Accession Description Interval E-value
CYCLIN_CCND3_rpt2 cd20578
second cyclin box found in G1/S-specific cyclin-D3 (CCND3); CCND3 is a regulatory component of ...
 84-188 2.62e-73

second cyclin box found in G1/S-specific cyclin-D3 (CCND3); CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410281  Cd Length: 105  Bit Score: 217.24  E-value: 2.62e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209915553  84 IAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGT 163
Cdd:cd20578    1 IAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGT 80

                         90       100
                 ....*....|....*....|....*
gi 209915553 164 EVDCLRACQEQIEAALRESLREASQ 188
Cdd:cd20578   81 EVDCLRACQEQIEAALRESLREASQ 105
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 2-66 2.56e-44

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 145.13  E-value: 2.56e-44
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 209915553   2 ELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLE 66
Cdd:cd20575    1 ELLCCEGTRRVPRAGPDPRLLGDQRVLQNLLRLEERYVPRVSYFQCVQREIKPYMRKMLAYWMLE 65
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 83-179 3.15e-16

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 71.89  E-value: 3.15e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209915553   83 VIAHDFLAFILHRLSLPRDRQalVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGacsmsGDELTELLAGITG 162
Cdd:pfam02984   1 PTPLSFLRRFSKAADYLHDLE--LRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLN-----SPEWTETLEHYTG 73

                          90
                  ....*....|....*..
gi 209915553  163 TEVDCLRACQEQIEAAL 179
Cdd:pfam02984  74 YSEEDLKPCVKLLLELL 90
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 26-66 2.58e-06

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 45.20  E-value: 2.58e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 209915553   26 RVLQSLLRLEERYVPRASYFqCVQREIKPHMRKMLAYWMLE 66
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYM-DQQPDINPKMRAILIDWLVE 40
 
Name Accession Description Interval E-value
CYCLIN_CCND3_rpt2 cd20578
second cyclin box found in G1/S-specific cyclin-D3 (CCND3); CCND3 is a regulatory component of ...
 84-188 2.62e-73

second cyclin box found in G1/S-specific cyclin-D3 (CCND3); CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410281  Cd Length: 105  Bit Score: 217.24  E-value: 2.62e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209915553  84 IAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGT 163
Cdd:cd20578    1 IAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGT 80

                         90       100
                 ....*....|....*....|....*
gi 209915553 164 EVDCLRACQEQIEAALRESLREASQ 188
Cdd:cd20578   81 EVDCLRACQEQIEAALRESLREASQ 105
CYCLIN_CCND2_rpt2 cd20577
second cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 86-184 3.88e-50

second cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410280  Cd Length: 105  Bit Score: 158.46  E-value: 3.88e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209915553  86 HDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGL----GACSMSGDELTELLAGIT 161
Cdd:cd20577    3 HDFIEHILRKLPLPKDKLPLIRKHAQTFIALCATDFKFAMYPPSMIATGSVGAAICGLqldrGDSSLSGDSLTELLAKIT 82

                         90       100
                 ....*....|....*....|...
gi 209915553 162 GTEVDCLRACQEQIEAALRESLR 184
Cdd:cd20577   83 NTDVDCLKACQEQIESVLVSNLR 105
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 2-66 2.56e-44

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 145.13  E-value: 2.56e-44
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 209915553   2 ELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLE 66
Cdd:cd20575    1 ELLCCEGTRRVPRAGPDPRLLGDQRVLQNLLRLEERYVPRVSYFQCVQREIKPYMRKMLAYWMLE 65
CYCLIN_CCND_rpt2 cd20516
second cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 84-180 6.54e-42

second cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410220  Cd Length: 98  Bit Score: 137.36  E-value: 6.54e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209915553  84 IAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSM-SGDELTELLAGITG 162
Cdd:cd20516    1 TPLDFLEHILHRLPLDSEDVDKVRKHAETFIALCATDYKFSSYPPSMIAAASILAALRGLLLHSGnSKEDLLEKLQQLTR 80

                         90
                 ....*....|....*...
gi 209915553 163 TEVDCLRACQEQIEAALR 180
Cdd:cd20516   81 IDEDLLRACQEQIEDLLE 98
CYCLIN_CCND1_rpt2 cd20576
second cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 86-188 1.41e-34

second cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410279  Cd Length: 110  Bit Score: 118.90  E-value: 1.41e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209915553  86 HDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACS----MSGDELTELLAGIT 161
Cdd:cd20576    3 HDFIEHFLSKMPLAEDTKQIIRKHAQTFVALCATDVKFISNPPSMIAAGSVAAAVQGLNLGNtnsfLSYQRLTRFLSQVI 82

                         90       100
                 ....*....|....*....|....*..
gi 209915553 162 GTEVDCLRACQEQIEAALRESLREASQ 188
Cdd:cd20576   83 KCDPDCLRACQEQIESLLESSLRQAQQ 109
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 3-66 1.73e-28

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 104.69  E-value: 1.73e-28
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 209915553   3 LLCCEGTRHaPRAGPD--PRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLE 66
Cdd:cd20515    1 LLCCEVDTE-RRAYRDrsPALLLDDRVLQNLLSLEERYLPSASYFKCVQTEIQPFMRKMVTTWMLE 65
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 1-66 7.93e-27

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 100.45  E-value: 7.93e-27
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 209915553   1 MELLCCEGTRhAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLE 66
Cdd:cd20574    1 MELLCCEVDT-IRRALPDPNLLYDDRVLQNLLTIEERYLPQCSYFKCVQKDIQPFMRRMVATWMLE 65
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 1-66 8.61e-21

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 84.65  E-value: 8.61e-21
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 209915553   1 MELLCCEgTRHAPRAGPDPRLLGDqRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLE 66
Cdd:cd20573    1 HQLLCCE-VETIRRAYLDANLLND-RVLQTMLKAEETCLPSVSYFKCVQKEILPSMRKIVATWMLE 64
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 83-179 3.15e-16

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 71.89  E-value: 3.15e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209915553   83 VIAHDFLAFILHRLSLPRDRQalVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGacsmsGDELTELLAGITG 162
Cdd:pfam02984   1 PTPLSFLRRFSKAADYLHDLE--LRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLN-----SPEWTETLEHYTG 73

                          90
                  ....*....|....*..
gi 209915553  163 TEVDCLRACQEQIEAAL 179
Cdd:pfam02984  74 YSEEDLKPCVKLLLELL 90
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 26-66 2.58e-06

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 45.20  E-value: 2.58e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 209915553   26 RVLQSLLRLEERYVPRASYFqCVQREIKPHMRKMLAYWMLE 66
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYM-DQQPDINPKMRAILIDWLVE 40
CYCLIN_AtCycD-like_rpt2 cd20544
second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant ...
 83-175 7.23e-05

second cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410247  Cd Length: 90  Bit Score: 40.37  E-value: 7.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209915553  83 VIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCAtDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGItg 162
Cdd:cd20544    1 VTPFSFLDYFISKIGLSDSREELLSRATELLLSTTK-DIRFLEYRPSVIAAAAILCALDELPPDDADDASSRLSLLLS-- 77

                         90
                 ....*....|...
gi 209915553 163 TEVDCLRACQEQI 175
Cdd:cd20544   78 PNKEKVKKCYELM 90
CYCLIN_vCyC_rpt2 cd20518
second cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle ...
 84-181 1.01e-04

second cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410222  Cd Length: 100  Bit Score: 40.23  E-value: 1.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209915553  84 IAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGT 163
Cdd:cd20518    1 LATDVTSPLLLKLKGGSDQLDALHHAVNTLITKALVDPNTGSLPPSLISAAGCLLLVPANVTPQTHSGGVLPRLASILGC 80

                         90
                 ....*....|....*...
gi 209915553 164 EVDCLRACQEQIEAALRE 181
Cdd:cd20518   81 SVSTLQAAVEQVLTSLSD 98
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
 85-175 2.55e-03

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 36.13  E-value: 2.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209915553  85 AHDFLAFILHRLSLPRDRQALvkkhAQTFLALCATDYTFAMYPPSMIATGSIgaavqgLGACSMSGDE--LTELLAGITG 162
Cdd:cd20537    3 PLSFLRRYLSLLGLDEKVRHL----ARYLLELSLLDYEFLKYRPSLIAAAAL------YLARKILGEPppSPQLLQLVTG 72

                         90
                 ....*....|...
gi 209915553 163 TEVDCLRACQEQI 175
Cdd:cd20537   73 YSENDLQECAKEL 85
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 27-66 7.01e-03

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 35.30  E-value: 7.01e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 209915553  27 VLQSLLRLEERYVPRASYFQcVQREIKPHMRKMLAYWMLE 66
Cdd:cd20504    6 IYEYLRESELKHRPKPDYMR-KQPDINPSMRSILVDWLVE 44
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 29-66 7.89e-03

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 35.20  E-value: 7.89e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 209915553  29 QSLLRLEERYVPRASYFQcVQREIKPHMRKMLAYWMLE 66
Cdd:cd20507   10 KYLRQLEKKYAIDPDYLS-GQPEITERMRAILVDWLVE 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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