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Conserved domains on  [gi|209863142|ref|NP_001129463|]
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keratin associated protein 10-4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Keratin_B2 super family cl37504
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 41-182 6.79e-12

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


The actual alignment was detected with superfamily member pfam01500:

Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 61.35  E-value: 6.79e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863142   41 SCCQPSCCVPSCCAPSCCVPSCCQPSCCAPAPCLTLICTPVSCVSSPCCQSsccTPSCCQQSSCQPACCTCSP------- 113
Cdd:pfam01500  18 GTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQPCCQTSCC---QPTCCQTSSCQTGCGGIGYgqegssg 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 209863142  114 --------CQPSCCVPVCCTPVCCTPVCCKPVCCTPICSGSSsccqpsccapvCCKPCSSLSLLCRPVCRPACCVPT 182
Cdd:pfam01500  95 avssrtrwCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQAS-----------CCRPSYCGQSCCRPACCCQCSEPT 160
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 41-182 6.79e-12

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 61.35  E-value: 6.79e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863142   41 SCCQPSCCVPSCCAPSCCVPSCCQPSCCAPAPCLTLICTPVSCVSSPCCQSsccTPSCCQQSSCQPACCTCSP------- 113
Cdd:pfam01500  18 GTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQPCCQTSCC---QPTCCQTSSCQTGCGGIGYgqegssg 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 209863142  114 --------CQPSCCVPVCCTPVCCTPVCCKPVCCTPICSGSSsccqpsccapvCCKPCSSLSLLCRPVCRPACCVPT 182
Cdd:pfam01500  95 avssrtrwCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQAS-----------CCRPSYCGQSCCRPACCCQCSEPT 160
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 41-182 6.79e-12

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 61.35  E-value: 6.79e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863142   41 SCCQPSCCVPSCCAPSCCVPSCCQPSCCAPAPCLTLICTPVSCVSSPCCQSsccTPSCCQQSSCQPACCTCSP------- 113
Cdd:pfam01500  18 GTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQPCCQTSCC---QPTCCQTSSCQTGCGGIGYgqegssg 94

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 209863142  114 --------CQPSCCVPVCCTPVCCTPVCCKPVCCTPICSGSSsccqpsccapvCCKPCSSLSLLCRPVCRPACCVPT 182
Cdd:pfam01500  95 avssrtrwCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQAS-----------CCRPSYCGQSCCRPACCCQCSEPT 160
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
98-142 2.78e-10

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 53.93  E-value: 2.78e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 209863142   98 CCQQSSCQPACCTCSPCQPSCCVPVCCTPVCCTPVCCKPVCCTPI 142
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 66-215 7.54e-10

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 55.95  E-value: 7.54e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863142   66 SCCAPAPCLTLICTPVSCVSSPCCQSSCCTPSCCQQSSCQPACCTCSPCQPSCCVPVCctPVCCTPVCCKPVCCTPiCSG 145
Cdd:pfam01500   2 ACCGTSFCGFPTCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTC--QPCCQTSCCQPTCCQT-SSC 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863142  146 SSSCCQPSCCAPVCCKPCSSLSLLCRPVCRPACCVPTSSCCASSCQPSCCGPTSSVSLLCRPACSRQACC 215
Cdd:pfam01500  79 QTGCGGIGYGQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCGQSCC 148
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
96-137 3.08e-09

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 51.23  E-value: 3.08e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 209863142   96 PSCCQQSSCQPACCTCSPCQPSCCVPVCCTPVCCTPVCCKPV 137
Cdd:pfam13885   4 PSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
39-73 9.39e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 46.99  E-value: 9.39e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 209863142   39 QPSCCQPSCCVPSCCAPSCCVPSCCQPSCCAPAPC 73
Cdd:pfam13885   8 QPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCC 42
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
39-71 1.47e-07

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 46.61  E-value: 1.47e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 209863142   39 QPSCCQPSCCVPSCCAPSCCVPSCCQPSCCAPA 71
Cdd:pfam13885  13 QPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
57-127 6.51e-06

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 41.98  E-value: 6.51e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 209863142   57 CCVPSCCQPSCCapapcltlictpvscvsspccqssccTPSCCQQSSCQPACCTCSPCQPSCCVPVCCTPV 127
Cdd:pfam13885   1 CCQPSCCQPSCC--------------------------QPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
39-100 1.33e-05

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 41.21  E-value: 1.33e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 209863142   39 QPSCCQPSCCVPSCCAPSCCVPSCCQPSCCAPapcltlictpvscvsspccqsSCCTPSCCQ 100
Cdd:pfam13885   3 QPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRP---------------------SCCRSSCCQ 43
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 3-138 5.04e-03

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 36.31  E-value: 5.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 209863142    3 ASTMSVCSDARTNSSWQVDDCPESCCEPCCCAPSCCQPSCCQPSCCVPSCCAPSCCVPSCCQPSCCAPAPCLTLICTPVs 82
Cdd:pfam01500  38 SCCQTSCCQPTTFQSSCCRPTCQPCCQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVSSRTRWCRPDCRVEGTCLPP- 116

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 209863142   83 cvsspccqssCCTPSCCQQSSCQPACCTCSPCQPSCCVPVCCTPVCCTPvCCKPVC 138
Cdd:pfam01500 117 ----------CCVVSCTPPTCCQLHHAQASCCRPSYCGQSCCRPACCCQ-CSEPTC 161
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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