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Conserved domains on  [gi|402743461|ref|NP_001129307|]
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probable C-mannosyltransferase DPY19L3 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Dpy19L3 cd20181
C-mannosyltransferase Dpy-19-like protein 3 (Dpy19L3); Dpy19 proteins are ...
47-713 0e+00

C-mannosyltransferase Dpy-19-like protein 3 (Dpy19L3); Dpy19 proteins are C-mannosyltransferases that mediate C-mannosylation of tryptophan residues on target proteins. C-mannosylation is the attachment of alpha-mannose to the indole C2 carbon of the first tryptophan residue in the consensus amino acid sequence Trp-Xaa-Xaa-Trp/Cys through a C-C bond. This reaction takes place in the endoplasmic reticulum (ER) lumen. Dpy19 is a transmembrane domain family whose name is derived from the Caenorhabditis elegans Dumpy mutant. In humans Dpy19L3 (also called protein Dpy-19 homolog 3) is a C-mannosyltransferase of R-spondin.


:

Pssm-ID: 439134  Cd Length: 667  Bit Score: 1264.37  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461  47 SSAVGGTVALCIGLLTSVYLATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQMLQAPTLLQGFHGLIYDNKTESMRT 126
Cdd:cd20181    1 STTVGGTVALCIGLLTSVYVATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQMLQAPSIQQGFHGLIYDNKTESMRT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 127 INLLQRMNIYQEVFLSVLYRVLPIQKYLEPVYFYIYTLFGLQAVYVTALYITSWLLSGTWLSGLLAALWYVTNRIDTTRV 206
Cdd:cd20181   81 INLLQRMNIYQEVFLSVLYRVLPIQKYLEPVYFYIYTLFGLQAVYVIALYITSWLLSGTWLSGLLAAVWYITNRIDTTRV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 207 EFTIPLRENWALPFFAIQIAAITYFLRPNLQPLSERLTLLAIFVSTFLFSLTWQFNQFMMLLQALVLFILDSLDMLPAVK 286
Cdd:cd20181  161 EFTIPLRENWALPFFAIQIAAITYFLRPNLQPLQERLTLLAIFISTFLFSLTWQFNQFMMLIQALVLFTLDCLDMLPTAK 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 287 ATWLYGIQISCLLLVCMLQFFNSMILGSLLISFNLSVLIVRKLQKNLKTGTFLIRIWKLLLHLLLVFCLTLFLNNIIKKI 366
Cdd:cd20181  241 VTWLYGIQISGLLLVCILQFFNSMILGSLLLSFNLSVLIVRKLQKNLKTGSFLNRLGKLLLHLALVLCLTLFLNNIIKKI 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 367 LNLKSDEHIFKFLKAKFGFGATRDFDANLYLCEEAFGLLPLNTFQRLSETLLFYAYMFVLLVTVVTASVVAFHNLSDSTS 446
Cdd:cd20181  321 LNLKSDEHIFKFLKAKFGFGATRDFDANLYLCEEAFGLLPFNTFERLSDTLLFYAYIFVLLLTVIVAAVVAFHNLSDSTN 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 447 LQPVDQTRKRVVDLKPEAAYNLIHTILFGVLALSTMRMKYLWTSHMCVFASFGLCSSEIWELILRLVHLCNPKRIWVMRY 526
Cdd:cd20181  401 QQSMGKMEKGTVDLKPEVAYNLIHTILFGFLALSTMRMKYLWTSHMCVFASFGLCSTELWELLLKSVHLYNPKRIRVMRY 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 527 SVPVLTLLCLCCKSWPGMMDELSELKEFYDPDTVELMNWINSNTPRKAVFAGSMQLLAGVKLCTGRTLTNHPHYEDKSLR 606
Cdd:cd20181  481 SVPILTLLYLCYKFWPGLMDELSELREFYDPDTVELMNWINSNTPRKAVFAGSMQLLAGVKLCTGRTLTNHPHYEDKSLR 560
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 607 ERTQAVYQIYAKRSPEEVHALLRSFGTDFVILEDSICYERRHHRGCRLRDLLDVANGHEMDGPGESDPDLRPADHPRFCE 686
Cdd:cd20181  561 ERTRQVYQIYAKRSPEEVHALLRSFGTDYVILEDSICYERRHRRGCRLRDLLDIANGHIMDGPGENDPDLKPADHPRFCE 640
                        650       660
                 ....*....|....*....|....*..
gi 402743461 687 EIKRNLPSYAAHFTRVFQNKTFHVYKL 713
Cdd:cd20181  641 EIKRNLPSYAAYFTRVFQNKTFHVYKL 667
 
Name Accession Description Interval E-value
Dpy19L3 cd20181
C-mannosyltransferase Dpy-19-like protein 3 (Dpy19L3); Dpy19 proteins are ...
47-713 0e+00

C-mannosyltransferase Dpy-19-like protein 3 (Dpy19L3); Dpy19 proteins are C-mannosyltransferases that mediate C-mannosylation of tryptophan residues on target proteins. C-mannosylation is the attachment of alpha-mannose to the indole C2 carbon of the first tryptophan residue in the consensus amino acid sequence Trp-Xaa-Xaa-Trp/Cys through a C-C bond. This reaction takes place in the endoplasmic reticulum (ER) lumen. Dpy19 is a transmembrane domain family whose name is derived from the Caenorhabditis elegans Dumpy mutant. In humans Dpy19L3 (also called protein Dpy-19 homolog 3) is a C-mannosyltransferase of R-spondin.


Pssm-ID: 439134  Cd Length: 667  Bit Score: 1264.37  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461  47 SSAVGGTVALCIGLLTSVYLATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQMLQAPTLLQGFHGLIYDNKTESMRT 126
Cdd:cd20181    1 STTVGGTVALCIGLLTSVYVATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQMLQAPSIQQGFHGLIYDNKTESMRT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 127 INLLQRMNIYQEVFLSVLYRVLPIQKYLEPVYFYIYTLFGLQAVYVTALYITSWLLSGTWLSGLLAALWYVTNRIDTTRV 206
Cdd:cd20181   81 INLLQRMNIYQEVFLSVLYRVLPIQKYLEPVYFYIYTLFGLQAVYVIALYITSWLLSGTWLSGLLAAVWYITNRIDTTRV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 207 EFTIPLRENWALPFFAIQIAAITYFLRPNLQPLSERLTLLAIFVSTFLFSLTWQFNQFMMLLQALVLFILDSLDMLPAVK 286
Cdd:cd20181  161 EFTIPLRENWALPFFAIQIAAITYFLRPNLQPLQERLTLLAIFISTFLFSLTWQFNQFMMLIQALVLFTLDCLDMLPTAK 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 287 ATWLYGIQISCLLLVCMLQFFNSMILGSLLISFNLSVLIVRKLQKNLKTGTFLIRIWKLLLHLLLVFCLTLFLNNIIKKI 366
Cdd:cd20181  241 VTWLYGIQISGLLLVCILQFFNSMILGSLLLSFNLSVLIVRKLQKNLKTGSFLNRLGKLLLHLALVLCLTLFLNNIIKKI 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 367 LNLKSDEHIFKFLKAKFGFGATRDFDANLYLCEEAFGLLPLNTFQRLSETLLFYAYMFVLLVTVVTASVVAFHNLSDSTS 446
Cdd:cd20181  321 LNLKSDEHIFKFLKAKFGFGATRDFDANLYLCEEAFGLLPFNTFERLSDTLLFYAYIFVLLLTVIVAAVVAFHNLSDSTN 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 447 LQPVDQTRKRVVDLKPEAAYNLIHTILFGVLALSTMRMKYLWTSHMCVFASFGLCSSEIWELILRLVHLCNPKRIWVMRY 526
Cdd:cd20181  401 QQSMGKMEKGTVDLKPEVAYNLIHTILFGFLALSTMRMKYLWTSHMCVFASFGLCSTELWELLLKSVHLYNPKRIRVMRY 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 527 SVPVLTLLCLCCKSWPGMMDELSELKEFYDPDTVELMNWINSNTPRKAVFAGSMQLLAGVKLCTGRTLTNHPHYEDKSLR 606
Cdd:cd20181  481 SVPILTLLYLCYKFWPGLMDELSELREFYDPDTVELMNWINSNTPRKAVFAGSMQLLAGVKLCTGRTLTNHPHYEDKSLR 560
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 607 ERTQAVYQIYAKRSPEEVHALLRSFGTDFVILEDSICYERRHHRGCRLRDLLDVANGHEMDGPGESDPDLRPADHPRFCE 686
Cdd:cd20181  561 ERTRQVYQIYAKRSPEEVHALLRSFGTDYVILEDSICYERRHRRGCRLRDLLDIANGHIMDGPGENDPDLKPADHPRFCE 640
                        650       660
                 ....*....|....*....|....*..
gi 402743461 687 EIKRNLPSYAAHFTRVFQNKTFHVYKL 713
Cdd:cd20181  641 EIKRNLPSYAAYFTRVFQNKTFHVYKL 667
Dpy19 pfam10034
Q-cell neuroblast polarization; Dyp-19, formerly known as DUF2211, is a transmembrane domain ...
56-713 0e+00

Q-cell neuroblast polarization; Dyp-19, formerly known as DUF2211, is a transmembrane domain family that is required to orient the neuroblast cells, QR and QL accurately on the anterior-posterior axis: QL and QR are born in the same anterior-posterior position, but polarise and migrate left-right asymmetrically, QL migrating towards the posterior and QR migrating towards the anterior. It is also required, with unc-40, to express mab-5 correctly in the Q cell descendants. The Dpy-19 protein derives from the C. elegans DUMPY mutant, Swiss:P34413.


Pssm-ID: 462945  Cd Length: 646  Bit Score: 861.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461   56 LCIGLLTSVYLATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQMLQAPTLLQGFHGLIYDNKTESMRTINLLQRMNI 135
Cdd:pfam10034   1 VGSGILYALHVSTLFENDRWFSHLSELEREISFRTEMGLYYSYYKTIIEAPSFLEGLYQLMNDNRTEYPDTINALQRFNL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461  136 YQEVFLSVLYRVLP-IQKYL-EPVYFYIYTLFGLQAVYVTALYITSWLLSGTWLSGLLAALWYVTNRIDTTRVEFTIPLR 213
Cdd:pfam10034  81 YPEVILAILYRIFRgIQNYLgEPVYFYIYFVFGLQGVYVSALFLYGWYLSGSWLGGILAVLWFFFNHGETTRVEWTPPLR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461  214 ENWALPFFAIQIAAITYFLRP-NLQPLSERLTLLAIFVSTFLFSLTWQFNQFMMLLQALVLFILDSLDMLPAVKATWLYG 292
Cdd:pfam10034 161 ENFALPFFALQMLALTYILKRkNISSASELFCYILLSASTFLFLLTWQFSQFVLLTQILSLFLLDSLGLVPSKKVAKIYL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461  293 IQISCLLLVCMLQFFNSMILGSLLISFNLSVLIVRKLQKNLKTGTFLIRIWKLLLHLLLVFCLTLFLNNIIKKILNLKSD 372
Cdd:pfam10034 241 SHLISLLLAFVLQFGNSMLLTSPLLSSLISILLIRYLQPNMKKGRFSFRLLKLLLHGLLVLFGTLTLKLLIKKLLNVEDD 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461  373 EHIFKFLKAKFGFGATRDFDANLYLCEEAFGLLPLNTFQRLSETLLFYAYMFVLLVTVVTASVVAFHNLSDS-------- 444
Cdd:pfam10034 321 AHIFDFLKAKFGLNSTRDFDTNLYTCAEEFDFLSKETFLRLTKTLLLPFYILVLLILLIKVLQSIYRRLKRYklsqapmq 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461  445 TSLQPVDQTRKRVVDLKPEAAYNLIHTILFGVLALSTMRMKYLWTSHMCVFASFGlCSSEIWELILRlvhlcnpkriWVM 524
Cdd:pfam10034 401 ESLPLEDGRIGERPELNGEVVYHVLQLLAFGLLALLIMRLKLLWTPHMCVFASLG-ASKQLWHFLFK----------KIF 469
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461  525 RYSVPVLTLLCLCCKSWPGMMDELSELKEFYDPDTVELMNWINSNTPRKAVFAGSMQLLAGVKLCTGRTLTNHPHYEDKS 604
Cdd:pfam10034 470 SSAVPTVILASMSYKGFPNIQEELSILGEFYNPDTEELMEWIKSNTPKDAVFAGSMPLMATVKLSTGRPIVNHPHYEDAG 549
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461  605 LRERTQAVYQIYAKRSPEEVHALLRSFGTDFVILEDSICYERRHHRGCRLRDLLDVANGHemdgpgesdpDLRPADHPRF 684
Cdd:pfam10034 550 LRERTEDVYSVYSRKPAEDVYKILTSLKVNYVILEDSICSERSRRRGCRMLDIWDVEDGH----------CPANRKGPRF 619
                         650       660
                  ....*....|....*....|....*....
gi 402743461  685 CEEIKrnLPSYAAHFTRVFQNKTFHVYKL 713
Cdd:pfam10034 620 CHEIK--LSNYVPYFTRVFWNRSYHVYKV 646
 
Name Accession Description Interval E-value
Dpy19L3 cd20181
C-mannosyltransferase Dpy-19-like protein 3 (Dpy19L3); Dpy19 proteins are ...
47-713 0e+00

C-mannosyltransferase Dpy-19-like protein 3 (Dpy19L3); Dpy19 proteins are C-mannosyltransferases that mediate C-mannosylation of tryptophan residues on target proteins. C-mannosylation is the attachment of alpha-mannose to the indole C2 carbon of the first tryptophan residue in the consensus amino acid sequence Trp-Xaa-Xaa-Trp/Cys through a C-C bond. This reaction takes place in the endoplasmic reticulum (ER) lumen. Dpy19 is a transmembrane domain family whose name is derived from the Caenorhabditis elegans Dumpy mutant. In humans Dpy19L3 (also called protein Dpy-19 homolog 3) is a C-mannosyltransferase of R-spondin.


Pssm-ID: 439134  Cd Length: 667  Bit Score: 1264.37  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461  47 SSAVGGTVALCIGLLTSVYLATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQMLQAPTLLQGFHGLIYDNKTESMRT 126
Cdd:cd20181    1 STTVGGTVALCIGLLTSVYVATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQMLQAPSIQQGFHGLIYDNKTESMRT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 127 INLLQRMNIYQEVFLSVLYRVLPIQKYLEPVYFYIYTLFGLQAVYVTALYITSWLLSGTWLSGLLAALWYVTNRIDTTRV 206
Cdd:cd20181   81 INLLQRMNIYQEVFLSVLYRVLPIQKYLEPVYFYIYTLFGLQAVYVIALYITSWLLSGTWLSGLLAAVWYITNRIDTTRV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 207 EFTIPLRENWALPFFAIQIAAITYFLRPNLQPLSERLTLLAIFVSTFLFSLTWQFNQFMMLLQALVLFILDSLDMLPAVK 286
Cdd:cd20181  161 EFTIPLRENWALPFFAIQIAAITYFLRPNLQPLQERLTLLAIFISTFLFSLTWQFNQFMMLIQALVLFTLDCLDMLPTAK 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 287 ATWLYGIQISCLLLVCMLQFFNSMILGSLLISFNLSVLIVRKLQKNLKTGTFLIRIWKLLLHLLLVFCLTLFLNNIIKKI 366
Cdd:cd20181  241 VTWLYGIQISGLLLVCILQFFNSMILGSLLLSFNLSVLIVRKLQKNLKTGSFLNRLGKLLLHLALVLCLTLFLNNIIKKI 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 367 LNLKSDEHIFKFLKAKFGFGATRDFDANLYLCEEAFGLLPLNTFQRLSETLLFYAYMFVLLVTVVTASVVAFHNLSDSTS 446
Cdd:cd20181  321 LNLKSDEHIFKFLKAKFGFGATRDFDANLYLCEEAFGLLPFNTFERLSDTLLFYAYIFVLLLTVIVAAVVAFHNLSDSTN 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 447 LQPVDQTRKRVVDLKPEAAYNLIHTILFGVLALSTMRMKYLWTSHMCVFASFGLCSSEIWELILRLVHLCNPKRIWVMRY 526
Cdd:cd20181  401 QQSMGKMEKGTVDLKPEVAYNLIHTILFGFLALSTMRMKYLWTSHMCVFASFGLCSTELWELLLKSVHLYNPKRIRVMRY 480
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 527 SVPVLTLLCLCCKSWPGMMDELSELKEFYDPDTVELMNWINSNTPRKAVFAGSMQLLAGVKLCTGRTLTNHPHYEDKSLR 606
Cdd:cd20181  481 SVPILTLLYLCYKFWPGLMDELSELREFYDPDTVELMNWINSNTPRKAVFAGSMQLLAGVKLCTGRTLTNHPHYEDKSLR 560
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 607 ERTQAVYQIYAKRSPEEVHALLRSFGTDFVILEDSICYERRHHRGCRLRDLLDVANGHEMDGPGESDPDLRPADHPRFCE 686
Cdd:cd20181  561 ERTRQVYQIYAKRSPEEVHALLRSFGTDYVILEDSICYERRHRRGCRLRDLLDIANGHIMDGPGENDPDLKPADHPRFCE 640
                        650       660
                 ....*....|....*....|....*..
gi 402743461 687 EIKRNLPSYAAHFTRVFQNKTFHVYKL 713
Cdd:cd20181  641 EIKRNLPSYAAYFTRVFQNKTFHVYKL 667
Dpy19 pfam10034
Q-cell neuroblast polarization; Dyp-19, formerly known as DUF2211, is a transmembrane domain ...
56-713 0e+00

Q-cell neuroblast polarization; Dyp-19, formerly known as DUF2211, is a transmembrane domain family that is required to orient the neuroblast cells, QR and QL accurately on the anterior-posterior axis: QL and QR are born in the same anterior-posterior position, but polarise and migrate left-right asymmetrically, QL migrating towards the posterior and QR migrating towards the anterior. It is also required, with unc-40, to express mab-5 correctly in the Q cell descendants. The Dpy-19 protein derives from the C. elegans DUMPY mutant, Swiss:P34413.


Pssm-ID: 462945  Cd Length: 646  Bit Score: 861.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461   56 LCIGLLTSVYLATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQMLQAPTLLQGFHGLIYDNKTESMRTINLLQRMNI 135
Cdd:pfam10034   1 VGSGILYALHVSTLFENDRWFSHLSELEREISFRTEMGLYYSYYKTIIEAPSFLEGLYQLMNDNRTEYPDTINALQRFNL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461  136 YQEVFLSVLYRVLP-IQKYL-EPVYFYIYTLFGLQAVYVTALYITSWLLSGTWLSGLLAALWYVTNRIDTTRVEFTIPLR 213
Cdd:pfam10034  81 YPEVILAILYRIFRgIQNYLgEPVYFYIYFVFGLQGVYVSALFLYGWYLSGSWLGGILAVLWFFFNHGETTRVEWTPPLR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461  214 ENWALPFFAIQIAAITYFLRP-NLQPLSERLTLLAIFVSTFLFSLTWQFNQFMMLLQALVLFILDSLDMLPAVKATWLYG 292
Cdd:pfam10034 161 ENFALPFFALQMLALTYILKRkNISSASELFCYILLSASTFLFLLTWQFSQFVLLTQILSLFLLDSLGLVPSKKVAKIYL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461  293 IQISCLLLVCMLQFFNSMILGSLLISFNLSVLIVRKLQKNLKTGTFLIRIWKLLLHLLLVFCLTLFLNNIIKKILNLKSD 372
Cdd:pfam10034 241 SHLISLLLAFVLQFGNSMLLTSPLLSSLISILLIRYLQPNMKKGRFSFRLLKLLLHGLLVLFGTLTLKLLIKKLLNVEDD 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461  373 EHIFKFLKAKFGFGATRDFDANLYLCEEAFGLLPLNTFQRLSETLLFYAYMFVLLVTVVTASVVAFHNLSDS-------- 444
Cdd:pfam10034 321 AHIFDFLKAKFGLNSTRDFDTNLYTCAEEFDFLSKETFLRLTKTLLLPFYILVLLILLIKVLQSIYRRLKRYklsqapmq 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461  445 TSLQPVDQTRKRVVDLKPEAAYNLIHTILFGVLALSTMRMKYLWTSHMCVFASFGlCSSEIWELILRlvhlcnpkriWVM 524
Cdd:pfam10034 401 ESLPLEDGRIGERPELNGEVVYHVLQLLAFGLLALLIMRLKLLWTPHMCVFASLG-ASKQLWHFLFK----------KIF 469
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461  525 RYSVPVLTLLCLCCKSWPGMMDELSELKEFYDPDTVELMNWINSNTPRKAVFAGSMQLLAGVKLCTGRTLTNHPHYEDKS 604
Cdd:pfam10034 470 SSAVPTVILASMSYKGFPNIQEELSILGEFYNPDTEELMEWIKSNTPKDAVFAGSMPLMATVKLSTGRPIVNHPHYEDAG 549
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461  605 LRERTQAVYQIYAKRSPEEVHALLRSFGTDFVILEDSICYERRHHRGCRLRDLLDVANGHemdgpgesdpDLRPADHPRF 684
Cdd:pfam10034 550 LRERTEDVYSVYSRKPAEDVYKILTSLKVNYVILEDSICSERSRRRGCRMLDIWDVEDGH----------CPANRKGPRF 619
                         650       660
                  ....*....|....*....|....*....
gi 402743461  685 CEEIKrnLPSYAAHFTRVFQNKTFHVYKL 713
Cdd:pfam10034 620 CHEIK--LSNYVPYFTRVFWNRSYHVYKV 646
Dpy19 cd20177
C-mannosyltransferase Dpy19; Dpy19 proteins are C-mannosyltransferases that mediate ...
47-710 0e+00

C-mannosyltransferase Dpy19; Dpy19 proteins are C-mannosyltransferases that mediate C-mannosylation of tryptophan residues on target proteins. C-mannosylation is the attachment of alpha-mannose to the indole C2 carbon of the first tryptophan residue in the consensus amino acid sequence Trp-Xaa-Xaa-Trp/Cys through a C-C bond. This reaction takes place in the endoplasmic reticulum (ER) lumen. Dpy19 is a transmembrane domain family whose name is derived from the Caenorhabditis elegans Dumpy mutant.


Pssm-ID: 439130  Cd Length: 657  Bit Score: 790.69  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461  47 SSAVGGTVALCIGLLTSVYLATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQMLQAPTLLQGFHGLIYDNKTESMRT 126
Cdd:cd20177    1 KILLGLLLALLVGVLYSLHLSTLFENDRHFSHLSELEREMTFRTEMGLYYSYYKQLIEAPSFLEGLYKLTHDNVTEYPHT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 127 INLLQRMNIYQEVFLSVLYRVLPIQK--------------------------YLEPVYFYIYTLFGLQAVYVTALYITSW 180
Cdd:cd20177   81 INTLKRFNLYPEVILAILYRVFPSIAnyfgiptkqcwqvrgedlppvescegLGEPAYFYIYVVFGLNGLVAGLLFLYGW 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 181 LLSGTWLSGLLAALWYVTNRIDTTRVEFTIPLRENWALPFFAIQIAAITYFLRPNLqplSERLTLLAIFVSTFLFSLTWQ 260
Cdd:cd20177  161 LLSGSILGGLLTVAFFFFNHGEATRVQWTPPLRESFAYPFLLLQILLITIYLRSNI---GKRFHLLAISISTFLFMLMWQ 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 261 FNQFMMLLQALVLFILDSLDMLPAVKATWLYGIQISCLLLVCMLQFFNSMILGSLLISFNLSVLIVRKLQKNLKTGtFLI 340
Cdd:cd20177  238 FSQFALLTQILSLFALYVLGYIPSSKVQTIILSHLISLLLAFVLLFGNEMLLTSLYLSSLLAFLIILYLQLRLKKS-FKF 316
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 341 RIWKLLLHLLLVFCLTLFLNNIIKKILNLKSDEHIFKFLKAKFGFGatRDFDANLYLCEEAFGLLPLNTFQRLSETLLFY 420
Cdd:cd20177  317 KLIIWLLQLILVFLGTLGLKLLLSKLLNVEDDAHIFKILKSKFGDY--RDFDTRLYTCAAEFDFLSLETFLRLSKTLLLP 394
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 421 AYMFVLLVTVVTASVVAFHNLSDSTSLQPVDQTRKRVvDLKPEAAYNLIHTILFGVLALSTMRMKYLWTSHMCVFASFGL 500
Cdd:cd20177  395 LYIVVLVVIAFLFLRVRLLTLNDSTLKESVNFTDSRL-ILNPEIVYNVLQLLAFGLLAILIMRLKLFWTPHMCILASLLL 473
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 501 CSSEIWELilrlvhlcnpKRIWVMRYSVPVLTLLCLCCKSWPGMMDELSELKEFYDPDTVELMNWINSNTPRKAVFAGSM 580
Cdd:cd20177  474 SKKLLWKL----------LLKKIFRLAVLFALLASMSYPGIPNLQEELSILGEFSNPDTEELMEWIKDNTPPDAVFAGSM 543
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 581 QLLAGVKLCTGRTLTNHPHYEDKSLRERTQAVYQIYAKRSPEEVHALLRSFGTDFVILEDSICYERRhHRGCRLRDLLDV 660
Cdd:cd20177  544 PLMANVKLSTGRPIVNHPHYEDAGLRERTKQVYSMYSRRPAEEVYNILKKLGVNYIILEDSICLSRR-RDGCSLPDIWDL 622
                        650       660       670       680       690
                 ....*....|....*....|....*....|....*....|....*....|
gi 402743461 661 ANGHEMDGPGesdpdlrpadhprfcEEIKRNLPSYAAHFTRVFQNKTFHV 710
Cdd:cd20177  623 EDPHNRGKPP---------------LCIRLLLEDYVPYFKLVFSNKTYRV 657
Dpy19L4 cd20180
C-mannosyltransferase Dpy-19-like protein 4 (Dpy19L4); Dpy19 proteins are ...
50-712 0e+00

C-mannosyltransferase Dpy-19-like protein 4 (Dpy19L4); Dpy19 proteins are C-mannosyltransferases that mediate C-mannosylation of tryptophan residues on target proteins. C-mannosylation is the attachment of alpha-mannose to the indole C2 carbon of the first tryptophan residue in the consensus amino acid sequence Trp-Xaa-Xaa-Trp/Cys through a C-C bond. This reaction takes place in the endoplasmic reticulum (ER) lumen. Dpy19 is a transmembrane domain family whose name is derived from the Caenorhabditis elegans Dumpy mutant. The function of Dpy19L4 (also called protein Dpy-19 homolog 4) is unknown.


Pssm-ID: 439133  Cd Length: 664  Bit Score: 586.81  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461  50 VGGTVALCIGLLTSVYLATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQMLQAPTLLQGFHGLIYDNKTESMRTINL 129
Cdd:cd20180    4 FGCLAAVTSGMMYAVYLSTYHERKFWFSNRQELEREITFQGDSAIYYSYYKDMLKAPSFERGVYELTHNNKTVSLKTINA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 130 LQRMNIYQEVFLSVLYRVLPIQKYLEPVYFYIYTLFGLQAVYVTALYITSWLLSGTWLSGLLAALWYVTNRIDTTRVEFT 209
Cdd:cd20180   84 VQQMSLYPELIASVLYQATGSNEVIEPVYFYIGIVFGLQGIYVTALFVTSWLMSGTWLAGMLTVAWFIINRVDTTRIEYS 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 210 IPLRENWALPFFAIQIAAITYFLRPNLQPLSERLTLLAIFVSTFLFSLTWQFNQFMMLLQALVLFILDSLDMLPAVKATW 289
Cdd:cd20180  164 IPLRENWALPYFACQVAALTGYLKSNLNTYAERFCYLLMSASTYTFMMMWEYSHYVLFLQAISLFLLDSFSLEQSDKVYE 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 290 LYGIQISCLLLVCMLQFFNSMILGSLLISFNLSVLIVRKLQKNLKTGTFlIRIWKLLLHLLLVFCLTLFLNNIIKKILNL 369
Cdd:cd20180  244 VYKVYLFSLFLGYLLQFENPALLVSPLLSLVAALMLAKCLQLNMKKGPF-VAKMIKVLHFYLVCTLTITLNFIMKMFVPH 322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 370 KSDEHIFKFLKAKFGFGATRDFDANLYLCEEAFGLLPLNTFQRLSETLLFYAYMFVLLVTVVTASVVAFHNLSDSTSLQP 449
Cdd:cd20180  323 KENEHLLKFLEVKFGLNTTKNFTMNWLLCQESLQAPSQDFFLRLTQSSLLPFYILVLIICLLSMLQVIFRRLSGKPLKET 402
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 450 VDQTRKRVVDlKPEAAYNLIHTILFGVLALSTMRMKYLWTSHMCVFASFGLCSSEIWELILRLVHLCNPKRI---WVMRY 526
Cdd:cd20180  403 VTLEDGRIGE-RPEIVYHVIHTILLGSLAMLFEGMKYLWTPYVCMLAAFGVCSPELWMTLFKWLRLRTVHPIllaLILSM 481
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 527 SVPVLTLLCLCCKSWPGMMDELSELKEFYDPDTVELMNWINSNTPRKAVFAGSMQLLAGVKLCTGRTLTNHPHYEDKSLR 606
Cdd:cd20180  482 AVPTIIGFSLWKEFFPRLMTELSELQEFYDPDTVELMTWIKRQAPVAAVFAGSPQLMGTIKLCTGWMVTSLPLYNDDDLL 561
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 607 ERTQAVYQIYAKRSPEEVHALLRSFGTDFVILEDSICYERRHHRGCRLRDLLDVANGHEMDGPGESdpdLRPADHPRFCE 686
Cdd:cd20180  562 KRNENIYQIYSKRSAEDIYKILTSYKANYLIIEDAICNEVGPVRGCRVKDLLDIANGHVVCEEGDK---YTYSKYGRFCH 638
                        650       660
                 ....*....|....*....|....*.
gi 402743461 687 EIKRNLPSYAAHFTRVFQNKTFHVYK 712
Cdd:cd20180  639 EIKINYSPYVNYFTRVYWNRSYFVYK 664
Dpy19L1 cd20178
C-mannosyltransferase Dpy-19-like protein 1 (Dpy19L1); Dpy19 proteins are ...
59-710 1.05e-90

C-mannosyltransferase Dpy-19-like protein 1 (Dpy19L1); Dpy19 proteins are C-mannosyltransferases that mediate C-mannosylation of tryptophan residues on target proteins. C-mannosylation is the attachment of alpha-mannose to the indole C2 carbon of the first tryptophan residue in the consensus amino acid sequence Trp-Xaa-Xaa-Trp/Cys through a C-C bond. This reaction takes place in the endoplasmic reticulum (ER) lumen. Dpy19 is a transmembrane domain family whose name is derived from the Caenorhabditis elegans Dumpy mutant. Dpy19L1 (also called protein Dpy-19 homolog 1) regulates neurite extension during development.


Pssm-ID: 439131  Cd Length: 652  Bit Score: 296.76  E-value: 1.05e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461  59 GLLTSVYLATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQMLQAPTLLQGFHGLIYDNKTESMRTINLLQRMNIYQE 138
Cdd:cd20178   13 GVLHWSHITHLFENDRHFSHLSTLEREMAFRTEMGLYYSYFKTIIEAPSFLNGVWMIMNDRLTEYPLVINTLKRFNLYPE 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 139 VFLSVLYRV-------LPIQ----------KYLEPV----------YFYIYTLFGLQAVYVTALYITSWLLSGTWLSGLL 191
Cdd:cd20178   93 VVLASWYRIytgimdfFGIQtktcwtvnrgEGLSPVesceglgdpaYFYVAVIFLLNGLMMSLFFIYGTYLSGSRLGGVV 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 192 AALWYVTNRIDTTRVEFTIPLRENWALPFFAIQIAAITYFLRpnlQPLSERLTLLAIFVSTFLFSLTWQFNQFMMLLQAL 271
Cdd:cd20178  173 TVLCFFFNHGECTRVMWTPPLRESFSYPFLVLQMLLVTYILR---APNLGRGSLIALCISNVLFMLPWQFAQFVLLTQIA 249
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 272 VLFILDSLDMLPAVKATWLYGIQISCLLLVCMLQFFNSMILGSLLISFNLSVLIVRKL-QKNLKTGTFLIRIWklLLHLL 350
Cdd:cd20178  250 SLFAVYVVGYIDSCKLQKILYAHMISLVVCFVLMFGNSMLLTSYYASSLVIIWGILALrPKFLKVNKSEVSLW--VIQGC 327
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 351 LVFCLTLFLNNIIKKILNLKSDEHIFKFLKAKfgFGATRDFDANLYLCEEAFGLLPLNTFQRLSETLLFYAYMFVLLVTV 430
Cdd:cd20178  328 AWLFGTVILKYLTSKVFGIADDAHIGNLLKSK--FTSYKDFDTLMYTCAAEFDFMEKETPLRYTKTLLLPVVLVVFAAIA 405
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 431 VTASVVAFHNLSdstslQPVDQTRKRVVDlKPEAAYNLIHTILFGVLALSTMRMKYLWTSHMCVFASFgLCSSEIWELIL 510
Cdd:cd20178  406 RKTIKDLWGVLA-----KKATHTRKEQFA-HGELVYHALQLLAYAVLAILIMRLKLFLTPHMCVMASL-VCSRQLFGWLF 478
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 511 RLVHlcnpkriwvmRYSVPVLTLLCLCCKSWPGMMDELSELKEFYDPDTVELMNWINSNTPRKAVFAGSMQLLAGVKLCT 590
Cdd:cd20178  479 CKVH----------PQAVVFAILAAMAIQGSANLQTQWNIIGEFSNLPQEELLEWIKYNTKPDAVFAGAMPTMASVKLSA 548
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 591 GRTLTNHPHYEDKSLRERTQAVYQIYAKRSPEEVHALLRSFGTDFVILEDSICYeRRHHRGCRLRDLLDVanghemdgpg 670
Cdd:cd20178  549 LRPIVNHPHYEDAGLRARTKIVYSMYSRKPAEEVKRELMKLGVNYYILEESWCV-RRSKPGCSMPEIWDV---------- 617
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|
gi 402743461 671 eSDPDlrPADHPRFCEEIKRNlpsYAAHFTRVFQNKTFHV 710
Cdd:cd20178  618 -EDPD--NAGKTPLCTLMSKD---SRPHFTTVFENSVYKV 651
Dpy19L2 cd20179
C-mannosyltransferase Dpy-19-like protein 2 (Dpy19L2); Dpy19 proteins are ...
54-710 1.20e-66

C-mannosyltransferase Dpy-19-like protein 2 (Dpy19L2); Dpy19 proteins are C-mannosyltransferases that mediate C-mannosylation of tryptophan residues on target proteins. C-mannosylation is the attachment of alpha-mannose to the indole C2 carbon of the first tryptophan residue in the consensus amino acid sequence Trp-Xaa-Xaa-Trp/Cys through a C-C bond. This reaction takes place in the endoplasmic reticulum (ER) lumen. Dpy19 is a transmembrane domain family whose name is derived from the Caenorhabditis elegans Dumpy mutant. Dpy19L2 (also called protein Dpy-19 homolog 2) deletion is a major cause of globozoospermia.


Pssm-ID: 439132  Cd Length: 652  Bit Score: 232.24  E-value: 1.20e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461  54 VALCIGLLTSVYLATLHENDLWFSNIKEVEREISFRTECGLYYSYYKQMLQAPTLLQGFHGLIYDNKTESMRTINLLQRM 133
Cdd:cd20179   10 IAVFVAILHWLHLVTLFENDRHFSHLSSLEREMTFRTEMGLYYSYFKTIIEAPSFLEGLWMIMNDRLTEYPLIINAIKRF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 134 NIYQEVFLSVLYRVL---------------------PIQKYL------EPVYFYIYTLFGLQAVYVTALYITSWLLSGTW 186
Cdd:cd20179   90 HLYPEVIIASWYCTFmgimnlfgletktcwnvtriePLNEVQsceglgDPACFYVGVIFILNGLMMGLFFMYGAYLSGTQ 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 187 LSGLLAALWYVTNRIDTTRVEFTIPLRENWALPFFAIQIAAITYFLRPNLqplSERLTLLAIFVSTFLFSLTWQFNQFMM 266
Cdd:cd20179  170 LGGLITVLCFFFNHGEATRVMWTPPLRESFSYPFLVLQMCILTLILRTSS---NDRRPFIALCLSNVAFMLPWQFAQFIL 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 267 LLQALVLFILDSLDMLPAVKATWLYGIQISCLLLVCMLQFFNSMILGSLLISFNL-SVLIVRKLQKNLKTGTFLIRIWkl 345
Cdd:cd20179  247 FTQIASLFPMYVVGYIEPSKFQKIIYMNMISVTLSFILMFGNSMYLSSYYSSSLLmTWAIILKRNEIQKLGVSKLNFW-- 324
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 346 LLHLLLVFCLTLFLNNIIKKILNLKSDEHIFKFLKAKFGfgATRDFDANLYLCEEAFGLLPLNTFQRLSETLLFYAYMFV 425
Cdd:cd20179  325 LIQGSAWWCGTIILKFLTSKILGVSDHIRLSDLIAARIL--RYTDFDTLIYTCAPEFDFMEKATPLRYTKTLLLPVVMVI 402
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 426 LLVTVVTASVVAFHNLSDSTSLqpvdqtRKRVVDlKPEAAYNLIHTILFGVLALSTMRMKYLWTSHMCVFASFgLCSSEI 505
Cdd:cd20179  403 TCFIFKKTVRDISYVLATNIYL------RKQLLE-HSELAFHTLQLLVFTALAILIMRLKMFLTPHMCVMASL-ICSRQL 474
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 506 WELILRLVHLCNpkriwvmrYSVPVLTLLCLccKSWPGMMDELSELKEFYDPDTVELMNWINSNTPRKAVFAGSMQLLAG 585
Cdd:cd20179  475 FGWLFRRVRFEK--------VIFGILTVMSI--QGYANLRNQWSIIGEFNNLPQEELLQWIKYSTTSDAVFAGAMPTMAS 544
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402743461 586 VKLCTGRTLTNHPHYEDKSLRERTQAVYQIYAKRSPEEVHALLRSFGTDFVILEDSICYERRhHRGCRLRDLLDVanghe 665
Cdd:cd20179  545 IKLSTLHPIVNHPHYEDADLRARTKIVYSTYSRKSAKEVRDKLLELHVNYYVLEEAWCVVRT-KPGCSMLEIWDV----- 618
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|....*
gi 402743461 666 mdgpgeSDPDlrPADHPRFCEEIKRNLPSYaahFTRVFQNKTFHV 710
Cdd:cd20179  619 ------EDPS--NAANPPLCSVLLEDARPY---FTTVFQNSVYRV 652
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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