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Conserved domains on  [gi|206725447|ref|NP_001128689|]
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leucine-rich repeat-containing protein 23 isoform a [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 146-304 2.68e-18

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 82.14  E-value: 2.68e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725447 146 ITDTEGISHPR-LETLNLKGNSIHMVTGLDP-EKLISLHtveLRGNQLESTLGI-NLPKLKNLYLAQNMLKKVEGLEDLS 222
Cdd:cd21340   14 ITKIDNLSLCKnLKVLYLYDNKITKIENLEFlTNLTHLY---LQNNQIEKIENLeNLVNLKKLYLGGNRISVVEGLENLT 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725447 223 NLTTLHL------------------------------RDNQIDTLSGFSrEMKSLQYLNLRGNMVANLGELAK-LRDLPK 271
Cdd:cd21340   91 NLEELHIenqrlppgekltfdprslaalsnslrvlniSGNNIDSLEPLA-PLRNLEQLDASNNQISDLEELLDlLSSWPS 169

                        170       180       190
                 ....*....|....*....|....*....|...
gi 206725447 272 LRALVLLDNPCTDETSYRQEALVQMPYLERLDK 304
Cdd:cd21340  170 LRELDLTGNPVCKKPKYRDKIILASKSLEVLDG 202
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 93-163 2.99e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 41.70  E-value: 2.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725447  93 LRYVDISENHLTDLSPLNYLTHLLWLKADGNRLRSAQ-----MNELPYLQIASFAYNQIT------DTEGISHPRLETLN 161
Cdd:cd21340  122 LRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEelldlLSSWPSLRELDLTGNPVCkkpkyrDKIILASKSLEVLD 201


                 ..
gi 206725447 162 LK 163
Cdd:cd21340  202 GK 203
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 146-304 2.68e-18

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 82.14  E-value: 2.68e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725447 146 ITDTEGISHPR-LETLNLKGNSIHMVTGLDP-EKLISLHtveLRGNQLESTLGI-NLPKLKNLYLAQNMLKKVEGLEDLS 222
Cdd:cd21340   14 ITKIDNLSLCKnLKVLYLYDNKITKIENLEFlTNLTHLY---LQNNQIEKIENLeNLVNLKKLYLGGNRISVVEGLENLT 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725447 223 NLTTLHL------------------------------RDNQIDTLSGFSrEMKSLQYLNLRGNMVANLGELAK-LRDLPK 271
Cdd:cd21340   91 NLEELHIenqrlppgekltfdprslaalsnslrvlniSGNNIDSLEPLA-PLRNLEQLDASNNQISDLEELLDlLSSWPS 169

                        170       180       190
                 ....*....|....*....|....*....|...
gi 206725447 272 LRALVLLDNPCTDETSYRQEALVQMPYLERLDK 304
Cdd:cd21340  170 LRELDLTGNPVCKKPKYRDKIILASKSLEVLDG 202
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
92-288 5.19e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.27  E-value: 5.19e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725447  92 HLRYVDISENHLTDL-SPLNYLTHLLWLKADGNRLRS--AQMNELPYLQIASFAYNQITD-TEGISH-PRLETLNLKGNS 166
Cdd:COG4886  137 NLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDlpEELGNLTNLKELDLSNNQITDlPEPLGNlTNLEELDLSGNQ 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725447 167 IhmvTGLDPE--KLISLHTVELRGNQLESTLGI-NLPKLKNLYLAQNMLKKVEGLEDLSNLTTLHLRDNQIDTLSGFSRE 243
Cdd:COG4886  217 L---TDLPEPlaNLTNLETLDLSNNQLTDLPELgNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELE 293

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 206725447 244 MKSLQYLNLRGNMVANLGELAKLRDLPKLRALVLLDNPCTDETSY 288
Cdd:COG4886  294 LLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLT 338
LRR_9 pfam14580
Leucine-rich repeat;
185-303 1.28e-09

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 56.70  E-value: 1.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725447  185 ELRGNQLE--STLGINLPKLKNLYLAQNMLKKVEGLEDLSNLTTLHLRDNQIDTLS-GFSREMKSLQYLNLRGNMVANLG 261
Cdd:pfam14580  25 DLRGYKIPiiENLGATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGeGLGEALPNLTELILTNNNLQELG 104

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 206725447  262 ELAKLRDLPKLRALVLLDNPCTDETSYRQEALVQMPYLERLD 303
Cdd:pfam14580 105 DLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLD 146
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 93-163 2.99e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.70  E-value: 2.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725447  93 LRYVDISENHLTDLSPLNYLTHLLWLKADGNRLRSAQ-----MNELPYLQIASFAYNQIT------DTEGISHPRLETLN 161
Cdd:cd21340  122 LRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEelldlLSSWPSLRELDLTGNPVCkkpkyrDKIILASKSLEVLD 201


                 ..
gi 206725447 162 LK 163
Cdd:cd21340  202 GK 203
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 93-285 8.10e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 38.29  E-value: 8.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725447  93 LRYVDISENHLTDLSPLN--YLTHLLWLKADGNRLRS---AQMNELPYLQIASFAYNQITDTEGISHPRLETLNLKGNSI 167
Cdd:PLN00113 142 LETLDLSNNMLSGEIPNDigSFSSLKVLDLGGNVLVGkipNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGY 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725447 168 HMVTGLDPEK---LISLHTVELRGN----QLESTLGiNLPKLKNLYLAQNMLKKV--EGLEDLSNLTTLHLRDNqidTLS 238
Cdd:PLN00113 222 NNLSGEIPYEiggLTSLNHLDLVYNnltgPIPSSLG-NLKNLQYLFLYQNKLSGPipPSIFSLQKLISLDLSDN---SLS 297

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 206725447 239 GFSRE----MKSLQYLNLRGNMVANLGELAkLRDLPKLRALVLLDNPCTDE 285
Cdd:PLN00113 298 GEIPElviqLQNLEILHLFSNNFTGKIPVA-LTSLPRLQVLQLWSNKFSGE 347
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 146-304 2.68e-18

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 82.14  E-value: 2.68e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725447 146 ITDTEGISHPR-LETLNLKGNSIHMVTGLDP-EKLISLHtveLRGNQLESTLGI-NLPKLKNLYLAQNMLKKVEGLEDLS 222
Cdd:cd21340   14 ITKIDNLSLCKnLKVLYLYDNKITKIENLEFlTNLTHLY---LQNNQIEKIENLeNLVNLKKLYLGGNRISVVEGLENLT 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725447 223 NLTTLHL------------------------------RDNQIDTLSGFSrEMKSLQYLNLRGNMVANLGELAK-LRDLPK 271
Cdd:cd21340   91 NLEELHIenqrlppgekltfdprslaalsnslrvlniSGNNIDSLEPLA-PLRNLEQLDASNNQISDLEELLDlLSSWPS 169

                        170       180       190
                 ....*....|....*....|....*....|...
gi 206725447 272 LRALVLLDNPCTDETSYRQEALVQMPYLERLDK 304
Cdd:cd21340  170 LRELDLTGNPVCKKPKYRDKIILASKSLEVLDG 202
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
92-288 5.19e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.27  E-value: 5.19e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725447  92 HLRYVDISENHLTDL-SPLNYLTHLLWLKADGNRLRS--AQMNELPYLQIASFAYNQITD-TEGISH-PRLETLNLKGNS 166
Cdd:COG4886  137 NLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDlpEELGNLTNLKELDLSNNQITDlPEPLGNlTNLEELDLSGNQ 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725447 167 IhmvTGLDPE--KLISLHTVELRGNQLESTLGI-NLPKLKNLYLAQNMLKKVEGLEDLSNLTTLHLRDNQIDTLSGFSRE 243
Cdd:COG4886  217 L---TDLPEPlaNLTNLETLDLSNNQLTDLPELgNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELE 293

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 206725447 244 MKSLQYLNLRGNMVANLGELAKLRDLPKLRALVLLDNPCTDETSY 288
Cdd:COG4886  294 LLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLT 338
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-303 3.36e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.88  E-value: 3.36e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725447  39 FPEEWLPTPLTEDMMKEGLSLLCKTGNGLAHAYVKLEVKERDLTDIYLLRSYIHLRYVDISENHLTDLSPLNYLTHLLWL 118
Cdd:COG4886   22 TTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTEL 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725447 119 KADGNRlrsaQMNELPYLQIASFAYNQITD-TEGISH-PRLETLNLKGNSIhmvTGLDPE--KLISLHTVELRGNQLES- 193
Cdd:COG4886  102 DLSGNE----ELSNLTNLESLDLSGNQLTDlPEELANlTNLKELDLSNNQL---TDLPEPlgNLTNLKSLDLSNNQLTDl 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725447 194 --TLGiNLPKLKNLYLAQNMLKKV-EGLEDLSNLTTLHLRDNQIDTLSGFSREMKSLQYLNLRGNmvaNLGELAKLRDLP 270
Cdd:COG4886  175 peELG-NLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNN---QLTDLPELGNLT 250

                        250       260       270
                 ....*....|....*....|....*....|...
gi 206725447 271 KLRALVLLDNPCTDETSyrqeaLVQMPYLERLD 303
Cdd:COG4886  251 NLEELDLSNNQLTDLPP-----LANLTNLKTLD 278
LRR_9 pfam14580
Leucine-rich repeat;
185-303 1.28e-09

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 56.70  E-value: 1.28e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725447  185 ELRGNQLE--STLGINLPKLKNLYLAQNMLKKVEGLEDLSNLTTLHLRDNQIDTLS-GFSREMKSLQYLNLRGNMVANLG 261
Cdd:pfam14580  25 DLRGYKIPiiENLGATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGeGLGEALPNLTELILTNNNLQELG 104

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 206725447  262 ELAKLRDLPKLRALVLLDNPCTDETSYRQEALVQMPYLERLD 303
Cdd:pfam14580 105 DLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLD 146
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
101-303 2.04e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.16  E-value: 2.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725447 101 NHLTDLSPLNYLTHLLWLKADGNRLRSAQMNELPYLQIASFAYNQITDTEGISHPRLETLNLKGNSIHMVTGLDPEKLIS 180
Cdd:COG4886    2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725447 181 LHTVELRGNQLEstlgiNLPKLKNLYLAQNmlkkvEGLEDLSNLTTLHLRDNQIDTLSGFSREMKSLQYLNLRGNMVANL 260
Cdd:COG4886   82 LSLLLLGLTDLG-----DLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDL 151

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 206725447 261 GElaKLRDLPKLRALVLLDNPCTDETsyrqEALVQMPYLERLD 303
Cdd:COG4886  152 PE--PLGNLTNLKSLDLSNNQLTDLP----EELGNLTNLKELD 188
LRR_8 pfam13855
Leucine rich repeat;
200-255 2.03e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 2.03e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 206725447  200 PKLKNLYLAQNMLKKVEG--LEDLSNLTTLHLRDNQIDTLSGFS-REMKSLQYLNLRGN 255
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPGAfSGLPSLRYLDLSGN 59
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
93-264 4.76e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.92  E-value: 4.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725447  93 LRYVDISENHLTDLS-PLNYLTHLLWLKADGNRLRS-AQMNELPYLQIASFAYNQITD-TEGISHPRLETLNLKGNSIH- 168
Cdd:COG4886  207 LEELDLSGNQLTDLPePLANLTNLETLDLSNNQLTDlPELGNLTNLEELDLSNNQLTDlPPLANLTNLKTLDLSNNQLTd 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725447 169 -MVTGLDPEKLISLHTVELRGNQLESTLGINLPKLKNLYLAQNMLKKVEGLEDLSNLTTLHLRDNQIDTLSGFSREMKSL 247
Cdd:COG4886  287 lKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLL 366

                        170
                 ....*....|....*..
gi 206725447 248 QYLNLRGNMVANLGELA 264
Cdd:COG4886  367 LTLGLLGLLEATLLTLA 383
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 200-241 1.03e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.15  E-value: 1.03e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 206725447  200 PKLKNLYLAQNMLKKVEGLEDLSNLTTLHLRDN-QIDTLSGFS 241
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLA 43
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 86-234 2.15e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.85  E-value: 2.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725447  86 LLRSYIHLRYVDISENHLTDLSPLNYLTHLlwlkadgnrlrsAQMNELPYLqiaSFAYNQITDTEGIS-------HPRLE 158
Cdd:COG5238  287 ALQGNTTLTSLDLSVNRIGDEGAIALAEGL------------QGNKTLHTL---NLAYNGIGAQGAIAlakalqeNTTLH 351

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725447 159 TLNLKGNSI--HMVTGL--DPEKLISLHTVELRGNqlestlgiNLPKLKNLYLAQNMLKkvegledlSNLTTLHLRDNQI 234
Cdd:COG5238  352 SLDLSDNQIgdEGAIALakYLEGNTTLRELNLGKN--------NIGKQGAEALIDALQT--------NRLHTLILDGNLI 415
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 93-163 2.99e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.70  E-value: 2.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725447  93 LRYVDISENHLTDLSPLNYLTHLLWLKADGNRLRSAQ-----MNELPYLQIASFAYNQIT------DTEGISHPRLETLN 161
Cdd:cd21340  122 LRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEelldlLSSWPSLRELDLTGNPVCkkpkyrDKIILASKSLEVLD 201


                 ..
gi 206725447 162 LK 163
Cdd:cd21340  202 GK 203
LRR_8 pfam13855
Leucine rich repeat;
222-281 2.49e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 2.49e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 206725447  222 SNLTTLHLRDNQIDTLSGFS-REMKSLQYLNLRGNMVANLGELAkLRDLPKLRALVLLDNP 281
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGA-FSGLPSLRYLDLSGNR 60
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 201-280 3.82e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.23  E-value: 3.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725447 201 KLKNLYLAQNMLKKVEGLEDLSNLTTLHLRDNQIDTLSGFSReMKSLQYLNLRGNmvaNLGELAKLRDLPKLRALVLLDN 280
Cdd:cd21340    3 RITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEF-LTNLTHLYLQNN---QIEKIENLENLVNLKKLYLGGN 78
LRR_8 pfam13855
Leucine rich repeat;
180-234 5.94e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.81  E-value: 5.94e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725447  180 SLHTVELRGNQLES---TLGINLPKLKNLYLAQNMLKKVEG--LEDLSNLTTLHLRDNQI 234
Cdd:pfam13855   2 NLRSLDLSNNRLTSlddGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 93-285 8.10e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 38.29  E-value: 8.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725447  93 LRYVDISENHLTDLSPLN--YLTHLLWLKADGNRLRS---AQMNELPYLQIASFAYNQITDTEGISHPRLETLNLKGNSI 167
Cdd:PLN00113 142 LETLDLSNNMLSGEIPNDigSFSSLKVLDLGGNVLVGkipNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGY 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725447 168 HMVTGLDPEK---LISLHTVELRGN----QLESTLGiNLPKLKNLYLAQNMLKKV--EGLEDLSNLTTLHLRDNqidTLS 238
Cdd:PLN00113 222 NNLSGEIPYEiggLTSLNHLDLVYNnltgPIPSSLG-NLKNLQYLFLYQNKLSGPipPSIFSLQKLISLDLSDN---SLS 297

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 206725447 239 GFSRE----MKSLQYLNLRGNMVANLGELAkLRDLPKLRALVLLDNPCTDE 285
Cdd:PLN00113 298 GEIPElviqLQNLEILHLFSNNFTGKIPVA-LTSLPRLQVLQLWSNKFSGE 347
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
81-238 9.94e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 37.61  E-value: 9.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 206725447  81 LTDIYLLRSYIHLRYVDISENHLTDLSPLNYLTHLLWLKADGNRLRSAQMNELP-YLQIASFAYNQITDTEGISHPRLET 159
Cdd:COG4886  240 LTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELElLLGLNSLLLLLLLLNLLELLILLLL 319

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 206725447 160 LNLKGNSIHMVTGLDPEKLISLHTVELRGNQLESTLGINLPKLKNLYLAQNMLKKVEGLEDLSNLTTLHLRDNQIDTLS 238
Cdd:COG4886  320 LTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTA 398
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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