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Conserved domains on  [gi|199559532|ref|NP_001128304|]
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jouberin isoform b [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
587-897 1.84e-37

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 145.82  E-value: 1.84e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199559532  587 WKRLPGQACRIPNKHLFSLNAgergcfcLDFSHNGRILAAAcaSRDGYpIILYEIPSGRFMRELCGHLNIIYDLSWSKDD 666
Cdd:COG2319   105 WDLATGLLLRTLTGHTGAVRS-------VAFSPDGKTLASG--SADGT-VRLWDLATGKLLRTLTGHSGAVTSVAFSPDG 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199559532  667 HYILTSSSDGTARIWknEINNTNTFRVLP-HPSFVYTAKFHPAvRELVVTGCYDSMIRIWKVemreDSAILVRQFDVHKS 745
Cdd:COG2319   175 KLLASGSDDGTVRLW--DLATGKLLRTLTgHTGAVRSVAFSPD-GKLLASGSADGTVRLWDL----ATGKLLRTLTGHSG 247

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199559532  746 FINSLCFDTEGHHMYSGDCTGVIVVWNtyVKINDLEHSVHHWTinkeiketefkgIPISYLEIHPNGKRLLIHTKDSTLR 825
Cdd:COG2319   248 SVRSVAFSPDGRLLASGSADGTVRLWD--LATGELLRTLTGHS------------GGVNSVAFSPDGKLLASGSDDGTVR 313

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 199559532  826 IMDLRIlvARKFVGAANYREKIHS-TLTPCGTFLFAGSEDGIVYVWNPETGEQVAMYSDlpFKSPIRDISYHP 897
Cdd:COG2319   314 LWDLAT--GKLLRTLTGHTGAVRSvAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG--HTGAVTSVAFSP 382
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
587-897 1.84e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 145.82  E-value: 1.84e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199559532  587 WKRLPGQACRIPNKHLFSLNAgergcfcLDFSHNGRILAAAcaSRDGYpIILYEIPSGRFMRELCGHLNIIYDLSWSKDD 666
Cdd:COG2319   105 WDLATGLLLRTLTGHTGAVRS-------VAFSPDGKTLASG--SADGT-VRLWDLATGKLLRTLTGHSGAVTSVAFSPDG 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199559532  667 HYILTSSSDGTARIWknEINNTNTFRVLP-HPSFVYTAKFHPAvRELVVTGCYDSMIRIWKVemreDSAILVRQFDVHKS 745
Cdd:COG2319   175 KLLASGSDDGTVRLW--DLATGKLLRTLTgHTGAVRSVAFSPD-GKLLASGSADGTVRLWDL----ATGKLLRTLTGHSG 247

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199559532  746 FINSLCFDTEGHHMYSGDCTGVIVVWNtyVKINDLEHSVHHWTinkeiketefkgIPISYLEIHPNGKRLLIHTKDSTLR 825
Cdd:COG2319   248 SVRSVAFSPDGRLLASGSADGTVRLWD--LATGELLRTLTGHS------------GGVNSVAFSPDGKLLASGSDDGTVR 313

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 199559532  826 IMDLRIlvARKFVGAANYREKIHS-TLTPCGTFLFAGSEDGIVYVWNPETGEQVAMYSDlpFKSPIRDISYHP 897
Cdd:COG2319   314 LWDLAT--GKLLRTLTGHTGAVRSvAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG--HTGAVTSVAFSP 382
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 611-907 1.02e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 125.91  E-value: 1.02e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199559532  611 GCFCLDFSHNGRILAAACASRDgypIILYEIPSGRFMRELCGHLNIIYDLSWSKDDHYILTSSSDGTARIWKneINNTNT 690
Cdd:cd00200    11 GVTCVAFSPDGKLLATGSGDGT---IKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD--LETGEC 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199559532  691 FRVL-PHPSFVYTAKFHPAvRELVVTGCYDSMIRIWKVEMREdsaiLVRQFDVHKSFINSLCFDTEGHHMYSGDctgviv 769
Cdd:cd00200    86 VRTLtGHTSYVSSVAFSPD-GRILSSSSRDKTIKVWDVETGK----CLTTLRGHTDWVNSVAFSPDGTFVASSS------ 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199559532  770 vWNTYVKIndlehsvhhWTINKEIKETEFKG--IPISYLEIHPNGKRLLIHTKDSTLRIMDLRilvARKFVGAANYREK- 846
Cdd:cd00200   155 -QDGTIKL---------WDLRTGKCVATLTGhtGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS---TGKCLGTLRGHENg 221

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 199559532  847 IHSTLT-PCGTFLFAGSEDGIVYVWNPETGEQVAMYSDlpFKSPIRDISYHPFENMVAFCAF 907
Cdd:cd00200   222 VNSVAFsPDGYLLASGSEDGTIRVWDLRTGECVQTLSG--HTNSVTSLAWSPDGKRLASGSA 281
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 643-682 2.87e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 2.87e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 199559532    643 SGRFMRELCGHLNIIYDLSWSKDDHYILTSSSDGTARIWK 682
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
644-681 6.76e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 6.76e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 199559532   644 GRFMRELCGHLNIIYDLSWSKDDHYILTSSSDGTARIW 681
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
587-897 1.84e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 145.82  E-value: 1.84e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199559532  587 WKRLPGQACRIPNKHLFSLNAgergcfcLDFSHNGRILAAAcaSRDGYpIILYEIPSGRFMRELCGHLNIIYDLSWSKDD 666
Cdd:COG2319   105 WDLATGLLLRTLTGHTGAVRS-------VAFSPDGKTLASG--SADGT-VRLWDLATGKLLRTLTGHSGAVTSVAFSPDG 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199559532  667 HYILTSSSDGTARIWknEINNTNTFRVLP-HPSFVYTAKFHPAvRELVVTGCYDSMIRIWKVemreDSAILVRQFDVHKS 745
Cdd:COG2319   175 KLLASGSDDGTVRLW--DLATGKLLRTLTgHTGAVRSVAFSPD-GKLLASGSADGTVRLWDL----ATGKLLRTLTGHSG 247

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199559532  746 FINSLCFDTEGHHMYSGDCTGVIVVWNtyVKINDLEHSVHHWTinkeiketefkgIPISYLEIHPNGKRLLIHTKDSTLR 825
Cdd:COG2319   248 SVRSVAFSPDGRLLASGSADGTVRLWD--LATGELLRTLTGHS------------GGVNSVAFSPDGKLLASGSDDGTVR 313

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 199559532  826 IMDLRIlvARKFVGAANYREKIHS-TLTPCGTFLFAGSEDGIVYVWNPETGEQVAMYSDlpFKSPIRDISYHP 897
Cdd:COG2319   314 LWDLAT--GKLLRTLTGHTGAVRSvAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG--HTGAVTSVAFSP 382
WD40 COG2319
WD40 repeat [General function prediction only];
600-874 1.31e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.57  E-value: 1.31e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199559532  600 KHLFSLNAGERGCFCLDFSHNGRILAAAcaSRDGyPIILYEIPSGRFMRELCGHLNIIYDLSWSKDDHYILTSSSDGTAR 679
Cdd:COG2319   153 KLLRTLTGHSGAVTSVAFSPDGKLLASG--SDDG-TVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVR 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199559532  680 IWknEINNTNTFRVLP-HPSFVYTAKFHPAvRELVVTGCYDSMIRIWKVemreDSAILVRQFDVHKSFINSLCFDTEGHH 758
Cdd:COG2319   230 LW--DLATGKLLRTLTgHSGSVRSVAFSPD-GRLLASGSADGTVRLWDL----ATGELLRTLTGHSGGVNSVAFSPDGKL 302

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199559532  759 MYSGDCTGVIVVWNtyvkindlehsvhhWTINKEIKETEFKGIPISYLEIHPNGKRLLIHTKDSTLRIMDLR-ILVARKF 837
Cdd:COG2319   303 LASGSDDGTVRLWD--------------LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAtGELLRTL 368

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 199559532  838 VGAANYrekIHS-TLTPCGTFLFAGSEDGIVYVWNPET 874
Cdd:COG2319   369 TGHTGA---VTSvAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 611-907 1.02e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 125.91  E-value: 1.02e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199559532  611 GCFCLDFSHNGRILAAACASRDgypIILYEIPSGRFMRELCGHLNIIYDLSWSKDDHYILTSSSDGTARIWKneINNTNT 690
Cdd:cd00200    11 GVTCVAFSPDGKLLATGSGDGT---IKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD--LETGEC 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199559532  691 FRVL-PHPSFVYTAKFHPAvRELVVTGCYDSMIRIWKVEMREdsaiLVRQFDVHKSFINSLCFDTEGHHMYSGDctgviv 769
Cdd:cd00200    86 VRTLtGHTSYVSSVAFSPD-GRILSSSSRDKTIKVWDVETGK----CLTTLRGHTDWVNSVAFSPDGTFVASSS------ 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199559532  770 vWNTYVKIndlehsvhhWTINKEIKETEFKG--IPISYLEIHPNGKRLLIHTKDSTLRIMDLRilvARKFVGAANYREK- 846
Cdd:cd00200   155 -QDGTIKL---------WDLRTGKCVATLTGhtGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS---TGKCLGTLRGHENg 221

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 199559532  847 IHSTLT-PCGTFLFAGSEDGIVYVWNPETGEQVAMYSDlpFKSPIRDISYHPFENMVAFCAF 907
Cdd:cd00200   222 VNSVAFsPDGYLLASGSEDGTIRVWDLRTGECVQTLSG--HTNSVTSLAWSPDGKRLASGSA 281
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 580-871 3.08e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 124.37  E-value: 3.08e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199559532  580 ESKEVIKWKRLPGQACRIPNKHLFSLNAgergcfCLDFSHNGRIlaaACASRDGYpIILYEIPSGRFMRELCGHLNIIYD 659
Cdd:cd00200    29 GDGTIKVWDLETGELLRTLKGHTGPVRD------VAASADGTYL---ASGSSDKT-IRLWDLETGECVRTLTGHTSYVSS 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199559532  660 LSWSKDDHYILTSSSDGTARIWkNEINNTNTFRVLPHPSFVYTAKFHPaVRELVVTGCYDSMIRIWKVEmredSAILVRQ 739
Cdd:cd00200    99 VAFSPDGRILSSSSRDKTIKVW-DVETGKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLR----TGKCVAT 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199559532  740 FDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNTYVKindlehsvhhwtinKEIKETEFKGIPISYLEIHPNGKRLLIHT 819
Cdd:cd00200   173 LTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG--------------KCLGTLRGHENGVNSVAFSPDGYLLASGS 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 199559532  820 KDSTLRIMDLRILV-ARKFVGaanYREKIHS-TLTPCGTFLFAGSEDGIVYVWN 871
Cdd:cd00200   239 EDGTIRVWDLRTGEcVQTLSG---HTNSVTSlAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 648-919 1.51e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.11  E-value: 1.51e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199559532  648 RELCGHLNIIYDLSWSKDDHYILTSSSDGTARIWkneinNTNTFRVL----PHPSFVYTAKFHpAVRELVVTGCYDSMIR 723
Cdd:cd00200     3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVW-----DLETGELLrtlkGHTGPVRDVAAS-ADGTYLASGSSDKTIR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199559532  724 IWKVEMREdsaiLVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNTyvkindlehsvhhwTINKEIKETEFKGIPI 803
Cdd:cd00200    77 LWDLETGE----CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV--------------ETGKCLTTLRGHTDWV 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199559532  804 SYLEIHPNGKRLLIHTKDSTLRIMDLRIL-VARKFVGaanYREKIHS-TLTPCGTFLFAGSEDGIVYVWNPETGEQVAMY 881
Cdd:cd00200   139 NSVAFSPDGTFVASSSQDGTIKLWDLRTGkCVATLTG---HTGEVNSvAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTL 215

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 199559532  882 SdlPFKSPIRDISYHPFENMVAFCAFGQNepilLYIYD 919
Cdd:cd00200   216 R--GHENGVNSVAFSPDGYLLASGSEDGT----IRVWD 247
WD40 COG2319
WD40 repeat [General function prediction only];
615-897 1.58e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.22  E-value: 1.58e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199559532  615 LDFSHNGRILAAACASRDgypIILYEIPSGRFMRELCGHLNIIYDLSWSKDDHYILTSSSDGTARIWknEINNTNTFRVL 694
Cdd:COG2319    42 LAASPDGARLAAGAGDLT---LLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW--DLATGLLLRTL 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199559532  695 -PHPSFVYTAKFHPAVReLVVTGCYDSMIRIWKVEMREdsaiLVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNt 773
Cdd:COG2319   117 tGHTGAVRSVAFSPDGK-TLASGSADGTVRLWDLATGK----LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD- 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199559532  774 yvkindlehsvhhWTINKEIKETEFKGIPISYLEIHPNGKRLLIHTKDSTLRIMDLR-ILVARKFVGAANYrekIHS-TL 851
Cdd:COG2319   191 -------------LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGHSGS---VRSvAF 254

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 199559532  852 TPCGTFLFAGSEDGIVYVWNPETGEQVAMYSDlpFKSPIRDISYHP 897
Cdd:COG2319   255 SPDGRLLASGSADGTVRLWDLATGELLRTLTG--HSGGVNSVAFSP 298
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 736-905 1.42e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.51  E-value: 1.42e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199559532  736 LVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWNTyvkindlehsvhhwtiNKEIKETEFKG--IPISYLEIHPNGK 813
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDL----------------ETGELLRTLKGhtGPVRDVAASADGT 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199559532  814 RLLIHTKDSTLRIMDLRIL-VARKFVGAANYrekIHS-TLTPCGTFLFAGSEDGIVYVWNPETGEQVAMYSDlpFKSPIR 891
Cdd:cd00200    65 YLASGSSDKTIRLWDLETGeCVRTLTGHTSY---VSSvAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRG--HTDWVN 139

                         170
                  ....*....|....
gi 199559532  892 DISYHPFENMVAFC 905
Cdd:cd00200   140 SVAFSPDGTFVASS 153
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 643-682 2.87e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 2.87e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 199559532    643 SGRFMRELCGHLNIIYDLSWSKDDHYILTSSSDGTARIWK 682
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
644-681 6.76e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 6.76e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 199559532   644 GRFMRELCGHLNIIYDLSWSKDDHYILTSSSDGTARIW 681
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 626-727 3.01e-04

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 42.35  E-value: 3.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 199559532  626 AACASRDGYP-IILYEIPSGRfMRELCGHLNIIYDLSWSKDDHYIL-TSSSDGTARIWKNEINNTNTFRVLPHPSFVYTA 703
Cdd:COG0823     2 AFTLSRDGNSdIYVVDLDGGE-PRRLTNSPGIDTSPAWSPDGRRIAfTSDRGGGPQIYVVDADGGEPRRLTFGGGYNASP 80

                          90       100
                  ....*....|....*....|....
gi 199559532  704 KFHPAVRELVVTGCYDSMIRIWKV 727
Cdd:COG0823    81 SWSPDGKRLAFVSRSDGRFDIYVL 104
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 736-772 4.61e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 4.61e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 199559532    736 LVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWN 772
Cdd:smart00320    4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
736-772 6.75e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 6.75e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 199559532   736 LVRQFDVHKSFINSLCFDTEGHHMYSGDCTGVIVVWN 772
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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