ly6/PLAUR domain-containing protein 2 precursor [Rattus norvegicus]
Ly-6/uPAR domain-containing protein( domain architecture ID 10061478)
LU (Ly-6 antigen/uPA receptor-like) domain-containing protein similar to GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2)
List of domain hits
Name | Accession | Description | Interval | E-value | ||
TFP_LU_ECD_LYPD2 | cd23620 | extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 2 (LYPD2) and similar ... |
22-100 | 1.58e-45 | ||
extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 2 (LYPD2) and similar proteins; LYPD2 is a lymphocyte antigen-6 family protein. It contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). : Pssm-ID: 467140 Cd Length: 79 Bit Score: 142.38 E-value: 1.58e-45
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Name | Accession | Description | Interval | E-value | |||
TFP_LU_ECD_LYPD2 | cd23620 | extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 2 (LYPD2) and similar ... |
22-100 | 1.58e-45 | |||
extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 2 (LYPD2) and similar proteins; LYPD2 is a lymphocyte antigen-6 family protein. It contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). Pssm-ID: 467140 Cd Length: 79 Bit Score: 142.38 E-value: 1.58e-45
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UPAR_LY6 | pfam00021 | u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087. |
25-100 | 1.14e-05 | |||
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087. Pssm-ID: 394978 Cd Length: 77 Bit Score: 40.60 E-value: 1.14e-05
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LU | smart00134 | Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ... |
23-105 | 2.78e-05 | |||
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins. Pssm-ID: 214530 Cd Length: 85 Bit Score: 39.83 E-value: 2.78e-05
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Name | Accession | Description | Interval | E-value | |||
TFP_LU_ECD_LYPD2 | cd23620 | extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 2 (LYPD2) and similar ... |
22-100 | 1.58e-45 | |||
extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 2 (LYPD2) and similar proteins; LYPD2 is a lymphocyte antigen-6 family protein. It contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). Pssm-ID: 467140 Cd Length: 79 Bit Score: 142.38 E-value: 1.58e-45
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TFP_LU_ECD_SLURP1_like | cd23560 | extracellular domain (ECD) found in the secreted Ly-6/uPAR-related protein 1 (SLURP-1)-like ... |
23-100 | 9.32e-35 | |||
extracellular domain (ECD) found in the secreted Ly-6/uPAR-related protein 1 (SLURP-1)-like family; The SLURP-1-like family includes SLURP-1 and Ly6/PLAUR domain-containing protein 2 (LYPD2). SLURP-1 (also called ARS component B, or ARS (component B)-81/S, or anti-neoplastic urinary protein (ANUP)) has an antitumor activity. It was found to be a marker of late differentiation of the skin. It is implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin. In vitro SLURP-1 down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it inhibits alpha-7-dependent nAChR currents in an allosteric manner. In T cells SLURP-1 may be involved in regulation of intracellular Ca(2+) signaling. It may also have an immunomodulatory function in the cornea. The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation. LYPD2 is a lymphocyte antigen-6 family protein and shows high sequence similarity with SLURP-1. Members in this family contain an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). Pssm-ID: 467090 Cd Length: 78 Bit Score: 114.85 E-value: 9.32e-35
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TFP_LU_ECD_GPIHBP1 | cd23575 | extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density ... |
22-105 | 2.68e-19 | |||
extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPI-HBP1) and similar proteins; GPI-HBP1 (also called GPI-anchored HDL-binding protein 1, or high density lipoprotein-binding protein 1) is an endothelial cell transporter for lipoprotein lipase. It mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries and anchors LPL on the surface of endothelial cells in the lumen of blood capillaries. GPI-HBP1 protects LPL against loss of activity, and against ANGPTL4-mediated unfolding. Thereby, it plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis. GPI-HBP1 binds chylomicrons and phospholipid particles that contain APOA5. It also binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL. GPI-HBP1 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). Pssm-ID: 467105 Cd Length: 83 Bit Score: 75.83 E-value: 2.68e-19
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TFP_LU_ECD_PSCA | cd23573 | extracellular domain (ECD) found in prostate stem cell antigen (PSCA) and similar proteins; ... |
22-103 | 1.87e-15 | |||
extracellular domain (ECD) found in prostate stem cell antigen (PSCA) and similar proteins; PSCA may be involved in the regulation of cell proliferation. It has a cell-proliferation inhibition activity in vitro. PSCA may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs. PSCA contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). Pssm-ID: 467103 Cd Length: 78 Bit Score: 65.93 E-value: 1.87e-15
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TFP_LU_ECD_SLURP1 | cd23619 | extracellular domain (ECD) found in secreted Ly-6/uPAR-related protein 1 (SLURP-1) and similar ... |
23-100 | 2.45e-12 | |||
extracellular domain (ECD) found in secreted Ly-6/uPAR-related protein 1 (SLURP-1) and similar proteins; SLURP-1 (also called ARS component B, or ARS (component B)-81/S, or anti-neoplastic urinary protein (ANUP)) has antitumor activity. It was found to be a marker of late differentiation of the skin. It is implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin. In vitro SLURP-1 down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it inhibits alpha-7-dependent nAChR currents in an allosteric manner. In T cells SLURP-1 may be involved in regulation of intracellular Ca(2+) signaling. It may also have an immunomodulatory function in the cornea. The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation. SLURP-1 contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). Pssm-ID: 467139 Cd Length: 78 Bit Score: 57.89 E-value: 2.45e-12
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TFP_LU_ECD_Ly6M | cd23552 | extracellular domain (ECD) found in Mus musculus Ly-6 family protein Ly-6M and similar ... |
17-100 | 2.22e-10 | |||
extracellular domain (ECD) found in Mus musculus Ly-6 family protein Ly-6M and similar proteins; Ly-6M is a novel member of the Ly-6 family of hematopoietic proteins. It contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). Pssm-ID: 467082 Cd Length: 80 Bit Score: 52.94 E-value: 2.22e-10
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TFP_LU_ECD_Ly6E | cd23543 | extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E ... |
22-100 | 1.94e-09 | |||
extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E (also called retinoic acid-induced gene E protein (RIG-E), or stem cell antigen 2 (SCA-2), or thymic shared antigen 1 (TSA-1)) is a GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. It restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion. It plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). It may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. Ly-6E contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). Pssm-ID: 467073 Cd Length: 78 Bit Score: 50.43 E-value: 1.94e-09
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TFP | cd00117 | three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU ... |
23-100 | 2.06e-06 | |||
three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances. Pssm-ID: 467060 Cd Length: 81 Bit Score: 42.86 E-value: 2.06e-06
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TFP_LU_ECD_Ly6PGE | cd23553 | extracellular domain (ECD) found in Danio rerio lymphocyte antigen 6 family member PGE (Ly6PGE) ... |
23-100 | 8.47e-06 | |||
extracellular domain (ECD) found in Danio rerio lymphocyte antigen 6 family member PGE (Ly6PGE) and similar proteins; Ly6PGE is an uncharacterized Ly-6/uPAR family protein. It contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). Pssm-ID: 467083 Cd Length: 77 Bit Score: 40.91 E-value: 8.47e-06
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UPAR_LY6 | pfam00021 | u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087. |
25-100 | 1.14e-05 | |||
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087. Pssm-ID: 394978 Cd Length: 77 Bit Score: 40.60 E-value: 1.14e-05
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TFP_LU_ECD_Ly6D | cd23542 | extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D ... |
20-100 | 1.18e-05 | |||
extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D (also called E48 antigen) is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion. It may act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Ly-6D contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). Pssm-ID: 467072 Cd Length: 79 Bit Score: 40.86 E-value: 1.18e-05
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LU | smart00134 | Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ... |
23-105 | 2.78e-05 | |||
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins. Pssm-ID: 214530 Cd Length: 85 Bit Score: 39.83 E-value: 2.78e-05
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Toxin_TOLIP | pfam00087 | Snake toxin and toxin-like protein; This family predominantly includes venomous neurotoxins ... |
23-100 | 5.65e-05 | |||
Snake toxin and toxin-like protein; This family predominantly includes venomous neurotoxins and cytotoxins from snakes, but also structurally similar (non-snake) toxin-like proteins (TOLIPs) such as Lymphocyte antigen 6D and Ly6/PLAUR domain-containing protein. Snake toxins are short proteins with a compact, disulphide-rich structure. TOLIPs have similar structural features (abundance of spaced cysteine residues, a high frequency of charge residues, a signal peptide for secretion and a compact structure) but, are not associated with a venom gland or poisonous function. They are endogenous animal proteins that are not restricted to poisonous animals. Pssm-ID: 395040 Cd Length: 70 Bit Score: 38.75 E-value: 5.65e-05
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TFP_LU_ECD_Prod1 | cd23583 | extracellular domain (ECD) found in Notophthalmus viridescens Prod1 and similar proteins; ... |
23-100 | 1.70e-04 | |||
extracellular domain (ECD) found in Notophthalmus viridescens Prod1 and similar proteins; Prod1 is a member of the three-finger protein superfamily implicated in salamander limb regeneration. It contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). Pssm-ID: 467113 Cd Length: 68 Bit Score: 37.23 E-value: 1.70e-04
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TFP_LU_ECD_uPAR_rpt1 | cd23556 | first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ... |
23-100 | 2.16e-04 | |||
first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD. Pssm-ID: 467086 Cd Length: 79 Bit Score: 37.44 E-value: 2.16e-04
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TFP_LU_ECD_LYPD6_like | cd23567 | extracellular domain (ECD) found in the Ly6/PLAUR domain-containing protein 6 (LYPD6)-like ... |
23-101 | 3.53e-03 | |||
extracellular domain (ECD) found in the Ly6/PLAUR domain-containing protein 6 (LYPD6)-like family; The LYPD6-like family includes LYPD6 and LYPD6B. LYPD6 acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain. It inhibits nicotine-induced Ca(2+) influx through nAChRs. It functions as a positive regulator of Wnt/beta-catenin signaling. LYPD6B (also called LYPD7) may act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it acts on nAChRs in a subtype- and stoichiometry-dependent manner. LYPD6B modulates specifically alpha-3(3):beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs; modulates alpha-3(2):alpha-5:beta-4(2) nAChRs in the context of CHRNA5/alpha-5 variant Asn-398, but not its wild-type sequence. LYPD6B also activates AP1 (PMA)-mediated transcriptional activation. Members in this family contain an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). Pssm-ID: 467097 Cd Length: 88 Bit Score: 34.25 E-value: 3.53e-03
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TFP_LU_ECD_CD59 | cd23554 | extracellular domain (ECD) found in CD59 glycoprotein and similar proteins; CD59 (also called ... |
23-100 | 6.98e-03 | |||
extracellular domain (ECD) found in CD59 glycoprotein and similar proteins; CD59 (also called 1F5 antigen, or 20 kDa homologous restriction factor, or HRF-20, or MAC-inhibitory protein (MAC-IP), or MEM43 antigen, or membrane attack complex inhibition factor (MACIF), or membrane inhibitor of reactive lysis (MIRL), or protectin) is an LY-6-like protein expressed in human lymphoid cells and inhibits the action of the complement membrane attack complex (MAC) on homologous cells. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is also involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. CD59 contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). Pssm-ID: 467084 Cd Length: 70 Bit Score: 33.06 E-value: 6.98e-03
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TFP_LU_ECD_Ly6L | cd23551 | extracellular domain (ECD) found in lymphocyte antigen 6L (Ly-6L) and similar proteins; Ly-6L ... |
23-101 | 7.76e-03 | |||
extracellular domain (ECD) found in lymphocyte antigen 6L (Ly-6L) and similar proteins; Ly-6L (also called lymphocyte antigen 6 complex locus protein L) contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). Pssm-ID: 467081 Cd Length: 86 Bit Score: 33.53 E-value: 7.76e-03
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TFP_LU_ECD_Ly6H | cd23549 | extracellular domain (ECD) found in lymphocyte antigen 6H (Ly-6H) and similar proteins; Ly-6H ... |
23-100 | 9.69e-03 | |||
extracellular domain (ECD) found in lymphocyte antigen 6H (Ly-6H) and similar proteins; Ly-6H may act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it inhibits alpha-3:beta-4-containing nAChRs maximum response. Ly-6H may play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. It seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons. Ly-6H contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). Pssm-ID: 467079 Cd Length: 88 Bit Score: 33.19 E-value: 9.69e-03
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Blast search parameters | ||||
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