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Conserved domains on  [gi|193207761|ref|NP_001122921|]
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Major facilitator superfamily (MFS) profile domain-containing protein [Caenorhabditis elegans]

Protein Classification

MFS transporter( domain architecture ID 1000272)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates; similar to Drosophila melanogaster organic cation transporter protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2A0119 super family cl36765
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 83-495 1.46e-62

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00898:

Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 212.57  E-value: 1.46e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761   83 ITEQFKLLCEDAKLEKLGTSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILCFFN 162
Cdd:TIGR00898 115 IVTEWDLVCEDAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGI 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  163 GGQSTISVVYMIENIPKRTRGYISTLIS--YSPNVILLGILAFFFQQWDRLALVISFLTVPAIIMLAFLHESPRWLMQKG 240
Cdd:TIGR00898 195 GGIWVQAVVLNTEFLPKKQRAIVGTLIQvfFSLGLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQG 274

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  241 QISHAKKVFLAIEKFDGvpaaKSLNETELENFLENEhdkqvadgNTEVGKQHSFWHLFKTKEIMTGTFVIAFTFFATTLI 320
Cdd:TIGR00898 275 RIEEALKILQRIAKING----KKLPAEVLSLSLEKD--------LSSSKKQYSFLDLFRTPNLRKTTLCLMMLWFTTAFS 342

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  321 NYSIMFNLGAVAGSIYMNSILIGLLRYSFSLFSGLLDYKFEKFDRKMchgICSVVTISIIVAIIaFCLTDTTATFSVLIR 400
Cdd:TIGR00898 343 YYGLVLDLGNLGGNIYLDLFISGLVELPAKLITLLLIDRLGRRYTMA---ASLLLAGVALLLLL-FVPVDLYFLRTALAV 418

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  401 IGVllscAMTSQAIIVASIASNELMPTAIRSISYSTAQLCSRFGIVFAPHVFhlnlYTGIDFPVLPYAILLAIGLaDFIF 480
Cdd:TIGR00898 419 LGK----FGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLV----YLGEKWLFLPLVLFGGLAL-LAGI 489

                         410
                  ....*....|....*
gi 193207761  481 FRFLIPETKNKPLED 495
Cdd:TIGR00898 490 LTLFLPETKGVPLPE 504
 
Name Accession Description Interval E-value
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 83-495 1.46e-62

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 212.57  E-value: 1.46e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761   83 ITEQFKLLCEDAKLEKLGTSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILCFFN 162
Cdd:TIGR00898 115 IVTEWDLVCEDAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGI 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  163 GGQSTISVVYMIENIPKRTRGYISTLIS--YSPNVILLGILAFFFQQWDRLALVISFLTVPAIIMLAFLHESPRWLMQKG 240
Cdd:TIGR00898 195 GGIWVQAVVLNTEFLPKKQRAIVGTLIQvfFSLGLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQG 274

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  241 QISHAKKVFLAIEKFDGvpaaKSLNETELENFLENEhdkqvadgNTEVGKQHSFWHLFKTKEIMTGTFVIAFTFFATTLI 320
Cdd:TIGR00898 275 RIEEALKILQRIAKING----KKLPAEVLSLSLEKD--------LSSSKKQYSFLDLFRTPNLRKTTLCLMMLWFTTAFS 342

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  321 NYSIMFNLGAVAGSIYMNSILIGLLRYSFSLFSGLLDYKFEKFDRKMchgICSVVTISIIVAIIaFCLTDTTATFSVLIR 400
Cdd:TIGR00898 343 YYGLVLDLGNLGGNIYLDLFISGLVELPAKLITLLLIDRLGRRYTMA---ASLLLAGVALLLLL-FVPVDLYFLRTALAV 418

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  401 IGVllscAMTSQAIIVASIASNELMPTAIRSISYSTAQLCSRFGIVFAPHVFhlnlYTGIDFPVLPYAILLAIGLaDFIF 480
Cdd:TIGR00898 419 LGK----FGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLV----YLGEKWLFLPLVLFGGLAL-LAGI 489

                         410
                  ....*....|....*
gi 193207761  481 FRFLIPETKNKPLED 495
Cdd:TIGR00898 490 LTLFLPETKGVPLPE 504
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 80-474 1.62e-31

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 124.23  E-value: 1.62e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  80 FYGITEQFKLLCEDAKLEKLGTSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILC 159
Cdd:cd17317   10 ESTIVTEWDLVCDRDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVG 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 160 FFNGGQSTISVVYMIENIPKRTRGYISTL--ISYSPNVILLGILAFFFQQWDRLALVISFltvPAIIMLAFLhesprwlm 237
Cdd:cd17317   90 VTSAGIFTVGFVLGMEIVGPKYRSFVGILfgLFWALGYMLLALLAYLIRDWRWLQLAISL---PGLLFLLLL-------- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 238 qkgqishakkvflaiekfdgvpaakslnetelenflenehdkqvadgntevgkqhsFWHLFKtkeimtgTFVIAFTFFAT 317
Cdd:cd17317  159 --------------------------------------------------------WWLPRR-------TIIVGLIWFVT 175

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 318 TLINYSIMFNLGAVAGSIYMNSILIGL---LRYSFSLFsgLLDYKFEKFDRKMCHGICSVvtISIIVAIIAFCLTDTTAT 394
Cdd:cd17317  176 SLVYYGLSLNSSNLGGNLYLNFFLSGLveiPAYFLALL--LLDRLGRRWTLSGSLLLAGL--ACLVTALLPDDENTLALT 251

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 395 FSVLIRIGVllscamtSQAIIVASIASNELMPTAIRSISYSTAQLCSRFGIVFAPHVFHLNLYtGIDFPVLPYAILLAIG 474
Cdd:cd17317  252 LALVGKFAI-------SAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIVLLGKI-GPLLPLIIFGVLALLG 323
Sugar_tr pfam00083
Sugar (and other) transporter;
92-496 2.04e-25

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 108.90  E-value: 2.04e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761   92 EDAKLEKLGTSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKF---TIFRTILCFFNGGQSTI 168
Cdd:pfam00083  43 ALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVyqlIVGRVLVGIGVGGASVL 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  169 SVVYMIENIPKRTRGYISTLisYSPNVILLGILAFFF----------QQWDRLALVISFLTVPAIIMLAFLHESPRWLMQ 238
Cdd:pfam00083 123 APMYISEIAPKKLRGALGSL--YQLAITFGILLAYIFglglnktsnsDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVE 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  239 KGQISHAKKVFlaiEKFDGVPAAKslnETELENFLENEHDKQvadgntevGKQHSFWHLFKTKEIMTGTFVIAFTFFATT 318
Cdd:pfam00083 201 KGRLEEAREVL---AKLRGVPDVD---RELDEIKDSLEAGQE--------AEKASWKELFSTKTRRQRLLIGVMLQIFQQ 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  319 L--INYSI-----MFNLGAVAGSIYMNsILIGLLRYSFSLFSGLLdykFEKFDRKMCHGICSVVTI--SIIVAIIAFCLT 389
Cdd:pfam00083 267 LtgINAIFyysttIFENLGLSDSFLVT-IIVGVVNFVFTFIAIFL---VDRFGRRPLLLLGAAGMAicFVILGIVALLGV 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  390 DTTATFSVLIRIGVLL--SCAMTSQAIIVASIASnELMPTAIR----SISYSTAQLCSRFGIVFAPHVFHL--NLYTGID 461
Cdd:pfam00083 343 SKSDWAGIVAIVFIALfiAFFAMGWGPVPWVIVS-ELFPLSVRskamALATAANWLANFLIGFLFPIITDAigLGYTFFI 421

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 193207761  462 FpvlpyAILLAIGladFIFFRFLIPETKNKPLEDF 496
Cdd:pfam00083 422 F-----AGLLVLF---IIFVFFFVPETKGRTLEEI 448
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
101-445 1.93e-10

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 62.30  E-value: 1.93e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 101 TSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILCFFNGGQSTISVVYMIENIPKR 180
Cdd:COG2814   51 VTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPE 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 181 TRGYISTLISYSPNV------ILLGILAFFFqQWDRLALVISFLTVPAIIMLAFLhesprwlmqkgqishakkvflaiek 254
Cdd:COG2814  131 RRGRALGLLGAGLGLgpalgpLLGGLLADLF-GWRWVFLVNAVLALLALLLLLRL------------------------- 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 255 fdgVPAAKSLNETELenflenehdkqvadgntevgkQHSFWHLFKTKEIMTGTFVIAFTFFATTLINYSI------MFNL 328
Cdd:COG2814  185 ---LPESRPAARARL---------------------RGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLplylqeVLGL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 329 GAVAGSIYMnsILIGLLRYSFSLFSGLLdykFEKFDRKmchgicSVVTISIIVAIIAFCLTDTTATFSVLIrIGVLLSCA 408
Cdd:COG2814  241 SASAAGLLL--ALFGLGGVLGALLAGRL---ADRFGRR------RLLLIGLLLLALGLLLLALAGSLWLLL-LALFLLGF 308

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 193207761 409 MTSQAIIVASIASNELMPTAIRSISYSTAQLCSRFGI 445
Cdd:COG2814  309 GFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
xylE PRK10077
D-xylose transporter XylE; Provisional
 109-495 8.72e-10

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 60.86  E-value: 8.72e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 109 MLGCVVFGQIG----DQYGRKTPMMFCLCMCFIfgimSALSADFKKFTIFR------TILCFFN-----GG-----QSTI 168
Cdd:PRK10077  65 LIGCIIGGALGgycsNRFGRRDSLKIAAVLFFI----SALGSAWPEFGFTSigpdntGYVPEFViyriiGGigvglASML 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 169 SVVYMIENIPKRTRGyisTLISYSPNVILLGILAFFFQQW-----DRLALVIS------FLT--VPAIIMLAFLH---ES 232
Cdd:PRK10077 141 SPMYIAEIAPAHIRG---KLVSFNQFAIIFGQLVVYFVNYfiarsGDASWLNTdgwrymFASeaIPALLFLMLLYfvpET 217

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 233 PRWLMQKGQISHAKKVflaIEKFDGVPAAKslneTELENFlenehdKQVAD-GNTEVGKQHSFWHLFKTKEIMTGTFVIA 311
Cdd:PRK10077 218 PRYLMSRGKQEQAEGI---LRKIMGNTLAT----QALQEI------KHSLDhGRKTGGKLLMFGVGVIVIGVMLSVFQQF 284

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 312 FTFFATTLINYSIMFNLGAVAGSIYMNSILIGLLRYSFSLfsgLLDYKFEKFDRKMChgicsVVTISIIVAIIAFCLTdt 391
Cdd:PRK10077 285 VGINVVLYYAPEIFKTLGASTDIALLQTIIVGVINLTFTV---LAIMTVDKFGRKPL-----QIIGALGMAIGMFSLG-- 354

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 392 TATFSVLIRIGVLLSC-------AMTSQAIIVASIAsnELMPTAIRSISYSTA---QLCSRFGIVFAPHVFHLNLYTGID 461
Cdd:PRK10077 355 TAFYTQAPGIVALLSMlfyvaafAMSWGPVCWVLLS--EIFPNAIRGKALAIAvaaQWIANYFVSWTFPMMDKNSWLVAH 432

                        410       420       430
                 ....*....|....*....|....*....|....*
gi 193207761 462 F-PVLPYAILLAIGLADFIFFRFLIPETKNKPLED 495
Cdd:PRK10077 433 FhNGFSYWIYGCMGVLAALFMWKFVPETKGKTLEE 467
 
Name Accession Description Interval E-value
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 83-495 1.46e-62

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 212.57  E-value: 1.46e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761   83 ITEQFKLLCEDAKLEKLGTSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILCFFN 162
Cdd:TIGR00898 115 IVTEWDLVCEDAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGI 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  163 GGQSTISVVYMIENIPKRTRGYISTLIS--YSPNVILLGILAFFFQQWDRLALVISFLTVPAIIMLAFLHESPRWLMQKG 240
Cdd:TIGR00898 195 GGIWVQAVVLNTEFLPKKQRAIVGTLIQvfFSLGLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQG 274

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  241 QISHAKKVFLAIEKFDGvpaaKSLNETELENFLENEhdkqvadgNTEVGKQHSFWHLFKTKEIMTGTFVIAFTFFATTLI 320
Cdd:TIGR00898 275 RIEEALKILQRIAKING----KKLPAEVLSLSLEKD--------LSSSKKQYSFLDLFRTPNLRKTTLCLMMLWFTTAFS 342

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  321 NYSIMFNLGAVAGSIYMNSILIGLLRYSFSLFSGLLDYKFEKFDRKMchgICSVVTISIIVAIIaFCLTDTTATFSVLIR 400
Cdd:TIGR00898 343 YYGLVLDLGNLGGNIYLDLFISGLVELPAKLITLLLIDRLGRRYTMA---ASLLLAGVALLLLL-FVPVDLYFLRTALAV 418

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  401 IGVllscAMTSQAIIVASIASNELMPTAIRSISYSTAQLCSRFGIVFAPHVFhlnlYTGIDFPVLPYAILLAIGLaDFIF 480
Cdd:TIGR00898 419 LGK----FGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLV----YLGEKWLFLPLVLFGGLAL-LAGI 489

                         410
                  ....*....|....*
gi 193207761  481 FRFLIPETKNKPLED 495
Cdd:TIGR00898 490 LTLFLPETKGVPLPE 504
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 80-474 1.62e-31

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 124.23  E-value: 1.62e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  80 FYGITEQFKLLCEDAKLEKLGTSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILC 159
Cdd:cd17317   10 ESTIVTEWDLVCDRDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVG 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 160 FFNGGQSTISVVYMIENIPKRTRGYISTL--ISYSPNVILLGILAFFFQQWDRLALVISFltvPAIIMLAFLhesprwlm 237
Cdd:cd17317   90 VTSAGIFTVGFVLGMEIVGPKYRSFVGILfgLFWALGYMLLALLAYLIRDWRWLQLAISL---PGLLFLLLL-------- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 238 qkgqishakkvflaiekfdgvpaakslnetelenflenehdkqvadgntevgkqhsFWHLFKtkeimtgTFVIAFTFFAT 317
Cdd:cd17317  159 --------------------------------------------------------WWLPRR-------TIIVGLIWFVT 175

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 318 TLINYSIMFNLGAVAGSIYMNSILIGL---LRYSFSLFsgLLDYKFEKFDRKMCHGICSVvtISIIVAIIAFCLTDTTAT 394
Cdd:cd17317  176 SLVYYGLSLNSSNLGGNLYLNFFLSGLveiPAYFLALL--LLDRLGRRWTLSGSLLLAGL--ACLVTALLPDDENTLALT 251

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 395 FSVLIRIGVllscamtSQAIIVASIASNELMPTAIRSISYSTAQLCSRFGIVFAPHVFHLNLYtGIDFPVLPYAILLAIG 474
Cdd:cd17317  252 LALVGKFAI-------SAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIVLLGKI-GPLLPLIIFGVLALLG 323
Sugar_tr pfam00083
Sugar (and other) transporter;
92-496 2.04e-25

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 108.90  E-value: 2.04e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761   92 EDAKLEKLGTSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKF---TIFRTILCFFNGGQSTI 168
Cdd:pfam00083  43 ALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVyqlIVGRVLVGIGVGGASVL 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  169 SVVYMIENIPKRTRGYISTLisYSPNVILLGILAFFF----------QQWDRLALVISFLTVPAIIMLAFLHESPRWLMQ 238
Cdd:pfam00083 123 APMYISEIAPKKLRGALGSL--YQLAITFGILLAYIFglglnktsnsDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVE 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  239 KGQISHAKKVFlaiEKFDGVPAAKslnETELENFLENEHDKQvadgntevGKQHSFWHLFKTKEIMTGTFVIAFTFFATT 318
Cdd:pfam00083 201 KGRLEEAREVL---AKLRGVPDVD---RELDEIKDSLEAGQE--------AEKASWKELFSTKTRRQRLLIGVMLQIFQQ 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  319 L--INYSI-----MFNLGAVAGSIYMNsILIGLLRYSFSLFSGLLdykFEKFDRKMCHGICSVVTI--SIIVAIIAFCLT 389
Cdd:pfam00083 267 LtgINAIFyysttIFENLGLSDSFLVT-IIVGVVNFVFTFIAIFL---VDRFGRRPLLLLGAAGMAicFVILGIVALLGV 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  390 DTTATFSVLIRIGVLL--SCAMTSQAIIVASIASnELMPTAIR----SISYSTAQLCSRFGIVFAPHVFHL--NLYTGID 461
Cdd:pfam00083 343 SKSDWAGIVAIVFIALfiAFFAMGWGPVPWVIVS-ELFPLSVRskamALATAANWLANFLIGFLFPIITDAigLGYTFFI 421

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 193207761  462 FpvlpyAILLAIGladFIFFRFLIPETKNKPLEDF 496
Cdd:pfam00083 422 F-----AGLLVLF---IIFVFFFVPETKGRTLEEI 448
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 101-495 3.32e-21

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 96.11  E-value: 3.32e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 101 TSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILCFFNGGQSTISVVYMIENIPKR 180
Cdd:cd17358   47 GSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKN 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 181 TRGYISTLISYSPNV-ILLGILAFFFQQWDRLALVISFLTVPAIIMLAFLHESPRWLMQKGQISHAKKVFLAIEKFDGVp 259
Cdd:cd17358  127 VRGALGSLNQLLVNIgILLGYVLGSFLPWRTLALIGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQFLRGKDAD- 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 260 aakslNETELENFLENEHDKQVADGNtevgkqhSFWHLFKTKEIMTGTFV-IAFTFF-----ATTLINY-SIMFNLGAVA 332
Cdd:cd17358  206 -----ISKEAAEIQEELAELEKEAKE-------SSFSDLFQRKYLKPLVIgLGLMLFqqlsgINAVIFYaSSIFDEAGSG 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 333 GSIYMNSILIGLLRYSFSLFSGLLdykFEKFDRKMChGICSVVTISIIVAIIA--FCLTDTTA---TFSVLIRIGVLLSC 407
Cdd:cd17358  274 LDPNTATIIIGVVQVVGTLVATLL---VDRLGRRPL-LLVSAIGMGIGLLALGlyFYLQEHGAllsSVSWLPLVGLVIYI 349

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 408 AMTSQAII-VASIASNELMPTAIRSISYSTAQLCSRFGIVFAPHVFH-LNLYTGIDFPVLPYAillAIGLADFIFFRFLI 485
Cdd:cd17358  350 ISFSIGLGpLPWVIMSEIFPAKIKGLAGSLVTLVNWLFAFIVTKTFPfLTLAWGASGTFWIFA---GICGLALVFVLLFV 426

                        410
                 ....*....|
gi 193207761 486 PETKNKPLED 495
Cdd:cd17358  427 PETKGKSLEE 436
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 76-491 4.44e-19

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 89.63  E-value: 4.44e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  76 FERQFYGIT--EQFKLLCEDAKLEKLG---TSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKK 150
Cdd:cd17357   25 VFKEFINDTlvDRYGLNLSDSELDLLWsliVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSKSAKS 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 151 FTIF---RTILCFFNGGQSTISVVYMIENIPKRTRGYISTLISYSPNV-ILLGI---LAFFFQQWDRLALVISFLTVPAI 223
Cdd:cd17357  105 PELLifgRFLVGIACGLSTGFVPMYLQEISPSELRGALGSLTQIGVTLgILLGQvfgLPSVLGTETLWPYLLFFPGIPAL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 224 IMLA---FLHESPRWLM-QKGQISHAKKvflAIEKFDGVpaakslnETELENFLENEHDKQVADGNTevgKQHSFWHLFK 299
Cdd:cd17357  185 LQLAalpFFPESPKFLLiSKGDEEEAEK---SLKFLRGI-------EDDVDQELEEIKKESEQMGDQ---KQVSLMQLLR 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 300 TKEIMTGTFVIAFTFFATTL-----INY---SIMFNLG-AVAGSIYMNSiLIGLLRYSFSLFSGLLdykFEKFDRKMCHG 370
Cdd:cd17357  252 DPSLRLPLLLVLVVSASQQFsginaIFFystFIFENAGfSPQLAEWANL-GIGIVNVLSTIVGPFL---IEKVGRRPLLL 327

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 371 ICSVVTISIIVAIIAFCLTDTTATFSVLIRIGVLLSCAMTSQAII--VASIASNELMPTAIRSISYSTAQLC---SRFGI 445
Cdd:cd17357  328 ISLSVCAVALLLMSVFLFLSEQNSWMSYGCIVAIFLFIFFFAIGLgpIPWFIGAELFPQAPRSAAQSLGSSVnwtSNFIV 407

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*.
gi 193207761 446 VFAphVFHLNLYTGIdFPVLPYAILLAIGladFIFFRFLIPETKNK 491
Cdd:cd17357  408 GMA--FPPLQSIGGG-FVFIIFAIPCALF---LLYLYRYLPETKGR 447
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 83-469 3.40e-18

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 85.81  E-value: 3.40e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  83 ITEQFKLLCEDAKLEKLGTSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILCFFN 162
Cdd:cd17374   23 IVTEWDLVCESQSLKSVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAV 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 163 GGQSTISVVYMIENIPKRTRGYISTLISYSPNV--ILLGILAFFFQQWDRLALVISfltVPaiIMLAFLhesprwlmqkg 240
Cdd:cd17374  103 SGISINTLILGTEWTTPRHRALAITLTSCFFSIgqMLLAGLAYAIRDWRLLQLVVS---VP--FFLFFL----------- 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 241 qishakkvflaiekfdgvpaakslnetelenflenehdkqvadgntevgkqhSFWHLFKTkeimtgTFVIAFTFFATTLI 320
Cdd:cd17374  167 ----------------------------------------------------YSWWLPKR------TLILSFVWFANSFS 188

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 321 NYSIMFNLGAVAGSIYMNSILIGLLRYSFSLFSGLLdykFEKFDRKMCHGICSVVTISIIVAIIaFCLTDTTATFSVLIR 400
Cdd:cd17374  189 YYGLSLDLQHLGLNVFLLQFLFGAVEVPARCLALFL---LNHMGRRISQAVLLLLAGLCILANI-FVPQEMQTLRTVLAV 264

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 193207761 401 IGVLLSCAmtsqAIIVASIASNELMPTAIRSISYSTAQLCSRFGIVFAPHVFHLNLYtgidFPVLPYAI 469
Cdd:cd17374  265 LGKGSSAA----AFTISYVYTAELFPTVLRQTGMGLNSMFARIGGILAPLIMLLGVY----SPLLPMII 325
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
 83-226 3.51e-17

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 82.86  E-value: 3.51e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  83 ITEQFKLLCEDAKLEKLGTSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILCFFN 162
Cdd:cd17447   23 IATEWDLVCDRKGLNQATATFFFAGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLASAFSVSYVMFAITRTLTGFAL 102

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 193207761 163 GGQSTISVVYMIENIPKRTRGYISTLIS--YSPNVILLGILAFFFQQWDRLALVISFLTVPAIIML 226
Cdd:cd17447  103 TGFSIISMVLCVEWVDIEHRTVAGVLISlfWTVGNMLLALVAYLIRDWRWLILAVTLPCAPGIITW 168
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 99-495 1.81e-16

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 82.00  E-value: 1.81e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761   99 LGTSIQMLGVMLGCVVFGQIGDQYGRKTPMMFcLCMCFIFGIMSALSADFKKFT----IFRTILCFFNGGQSTISVVYMI 174
Cdd:TIGR00879  75 LVVSIFLVGGFIGALFAGWLSDRFGRKKSLLI-IALLFVIGAILMGLAAFALSVemliVGRVLLGIGVGIASALVPMYLS 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  175 ENIPKRTRGYistLISYSPNVILLGIL-AFFFQ----------QWDRLALVISFLTVPAIIMLAFLHESPRWLMQKGQIS 243
Cdd:TIGR00879 154 EIAPKALRGA---LTSLYQLAITFGILvAYGFGsgkvslnntlGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVE 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  244 HAKKVFLAIEKFDGVpaakslnETELENFLENEHDKQVADGNTEVGKQHSFWHLFKTK--EIMTGTFVIAFTFFA--TTL 319
Cdd:TIGR00879 231 EARKSLARLRGTSGE-------DKELLDELELIDIKRSIEKRSVQPSWGSLFSSTRRIrrRLFLGVVLQWFQQFTgiNAI 303

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  320 INYS--IMFNLGAVAGSIYMNSILIGLLRYSFSLFSGLLdykFEKFDRKMCHGICSVVtISIIVAIIAFCLTDTTATFSV 397
Cdd:TIGR00879 304 MYYSptIFENAGVSTDHAFLVSIIVGAVNFAFTFVAIFL---VDRFGRRPLLLIGAAG-MAICLFVLGILGASFVTGSSK 379

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  398 LIRIGVLLSCAM------TSQAIIVASIASnELMPTAIRSISYSTAQLCSRFGivfaphvfhlNLYTGIDFPVL------ 465
Cdd:TIGR00879 380 SSGNVAIVFILLfiaffaMGWGPVPWVIVS-EIFPLSLRPKGISIAVAANWLA----------NFIVGFLFPTMlesigv 448

                         410       420       430
                  ....*....|....*....|....*....|..
gi 193207761  466 --PYAILLAIGLADFIFFRFLIPETKNKPLED 495
Cdd:TIGR00879 449 ggVFIFFGGLNVLGLIFVYFFLPETKGRTLEE 480
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
 72-476 3.50e-15

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 76.74  E-value: 3.50e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  72 KEMTFERQFYGITEQFKLLCEDAKLEKLGTSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKF 151
Cdd:cd17377   16 KHVHFSSSFTSIVSEWFLVGNAAYKVSLASSFFFAGVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFF 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 152 TIFRTILCFFNGGQSTISVVYMIENIPKRTRGYISTL--ISYSPNVILLGILAFFFQQWDRLALVISfltVPAIIMLAFl 229
Cdd:cd17377   96 AVSRFLVGVMNGGMSLVAFVLLNECVGKSYWALAGSLggLFFAVGIAQYALLGYFIRSWRTLAVVVN---LQGTLVFLL- 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 230 hesprwlmqkgqishakKVFLAiekfdgvpaakslnetelenflenehdkqvadgntevgkqhsfWHlfktkeimtgTFV 309
Cdd:cd17377  172 -----------------SLFIP-------------------------------------------GR----------TLI 181

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 310 IAFTFFATTLINYSIMFNLGAVAGSIYMNSILIGLLRY-SFSLFSGLLDYKFEKFDRKMChGICSVVTISIIVAIIAFCL 388
Cdd:cd17377  182 LMYVWFVCSLVYYGLTLNAGDLGGNIYLNLALSGLVELpAYPLCIYLINQKWSGRRRTLA-GFLFLGGIACLLVMFVPEK 260

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 389 TDTTATFSVLIRIGVLLSCAMTSQAIIVASIASNELMPTAIRSISYSTAQLCSRFGIVFAPHVFHLNLYTgidfPVLPYA 468
Cdd:cd17377  261 KDSGVFAVVNSTSLSLLGKLTISAAFNIVYIYTSELYPTVVRNAGLGVCSMFSRVGGIIAPFIPSLKSVQ----WSLPFI 336


                 ....*...
gi 193207761 469 ILLAIGLA 476
Cdd:cd17377  337 VFGASGLS 344
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
 83-216 4.07e-15

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 76.69  E-value: 4.07e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  83 ITEQFKLLCEDAKLEKLGTSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILCFFN 162
Cdd:cd17446   21 IITEWDLVCNHRALRQLAQSIYMAGVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMAL 100

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 193207761 163 GGQSTISVVYMIENIPKRTRGYISTLISYSPNV--ILLGILAFFFQQWDRLALVIS 216
Cdd:cd17446  101 SGIVLNSVSLNVEWMPTRVRAVVGTLLGYCYTLgqLILAGVAYAIRDWRWLQLAVS 156
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 82-241 4.85e-14

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 73.76  E-value: 4.85e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  82 GITEQFKLlceDAKLEKLGTSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILCFF 161
Cdd:cd17359   26 FLQTDFNL---TPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLA 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 162 NGGQSTISVVYMIENIPKRTRGYISTLISYSpnvILLGILA-----FFFQQWDRLALVIS--------FLTVPAIIMLA- 227
Cdd:cd17359  103 VGGASALVPMYIAEVAPAEIRGRLVSLNQLM---IVFGQLLayivnYLIANAGGADWLGAegwrwmlgLEAIPAILFLLg 179

                        170
                 ....*....|....*.
gi 193207761 228 --FLHESPRWLMQKGQ 241
Cdd:cd17359  180 mlFIPESPRWLVSKGK 195
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 99-476 5.47e-14

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 73.40  E-value: 5.47e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  99 LGTSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILCFFNGGQSTISVVYMIENIP 178
Cdd:cd17316   40 LLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAP 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 179 KRTRGYISTLISYSPNV-ILLGILAFFF------QQWD-RLALVISflTVPAIIMLAFLhesprwlmqkgqishaKKVFL 250
Cdd:cd17316  120 SKRRGFALGLLQSGWALgALLAALVASLlipllsGDWGwRILFLIG--ALPALLALLLR----------------RRTLL 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 251 AIekfdgvpaakslnetelenflenehdkqvadgntevgkqhsfwhlfktkeIMTGTFVIAFTFFaTTLINYSIMFNLGA 330
Cdd:cd17316  182 LI--------------------------------------------------LLWFFISFGYYGL-TTFLPTYLQTVLGL 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 331 VAGSIYMNSILIGLLRYSFSLFSGLLdykFEKFDRKMCHGICSVvtISIIVAIIAFCLTDTTATFSVLIRIGVLLSCAMT 410
Cdd:cd17316  211 SPATSSLYLLLISLGALVGALIAGLL---SDRIGRKKTLVIGLI--LSGILALPLFYLLSGSPTLLLLLLFILSFFVGGV 285

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 193207761 411 SQAIIvasIASNELMPTAIRSISYSTAQLCSRFGIVFAPHVFHLNLYTGIDFPVLPYAILLAIGLA 476
Cdd:cd17316  286 WGALY---AYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVA 348
MFS_SLC22A16_CT2 cd17375
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...
 83-224 1.14e-13

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340933 [Multi-domain]  Cd Length: 341  Bit Score: 72.09  E-value: 1.14e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  83 ITEQFKLLCEDAKLEKLGTSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILCFFN 162
Cdd:cd17375   23 IVTDWDLVCDREWLAKLIQPIFMLGVLLGAVIFGDIADRIGRRPVLWFTSTGQFVFGIAVAFTFDYYSFVIVRFLLAMVS 102

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 193207761 163 GGQSTISVVYMIENIPKRTRGYISTLIS--YSPNVILLGILAFFFQQWDRLALVISFLTVPAII 224
Cdd:cd17375  103 SGYLVVVFVYVTEFTGIKARTWASMHVHafFAVGIMVVALVGYLVRTWWIYQIILSLVTIPFIL 166
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 83-228 4.16e-12

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 67.38  E-value: 4.16e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  83 ITEQFKLLCEDAKLEKLGTSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILCFFN 162
Cdd:cd17379   21 IVTEFNLVCEDAWKLDLFQSSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFG 100

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 193207761 163 GGQSTISVVYMIENIPKRTRGYISTLIS--YSPNVILLGILAFFFQQWDRLALVIsflTVPAIIMLAF 228
Cdd:cd17379  101 KGGWMTGYVLVTEFVGSKYRRTVGIVYQmfFTLGLLILPGIAYFIPHWRWLQLAV---TLPNFLFLLY 165
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 102-449 1.08e-11

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 66.61  E-value: 1.08e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  102 SIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILCFFNGGQSTISVVYMIENIPKRT 181
Cdd:TIGR00895  59 SAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRF 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  182 RGYISTL--ISYSPNVILLGILA------FFFQQWDRLALVISFLTVPAIIMlaFLHESPRWLMQKGQIShAKKVFLAIE 253
Cdd:TIGR00895 139 RGTAVGLmfCGYPIGAAVGGFLAgwlipvFGWRSLFYVGGIAPLLLLLLLMR--FLPESIDFLVSKRPET-VRRIVNAIA 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  254 KFDGVPAAKSLNEtelenflenehDKQVADGNTEVGKqhsfwhLFKTKEIMTGTFVIAFTFFATTLINYSIM-------- 325
Cdd:TIGR00895 216 PQMQAEAQSALPE-----------QKSTQGTKRSVFK------ALFQGKTARITVLLWLLYFMLLVGVYFLTnwlpklmv 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  326 -----FNLGAVAGSIYMNSILIGLLrysfsLFSGLLDykfeKFDRKMchgicsVVTISIIVAIIAFCLTDTTATFSVLIR 400
Cdd:TIGR00895 279 elgfsLSLAATGGALFNFGGVIGSI-----IFGWLAD----RLGPRV------TALLLLLGAVFAVLVGSTLFSPTLLLL 343

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 193207761  401 IGVLLSCAMTSqAIIVASIASNELMPTAIRSISYSTAQLCSRFGIVFAP 449
Cdd:TIGR00895 344 LGAIAGFFVNG-GQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGP 391
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 93-237 9.87e-11

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 63.36  E-value: 9.87e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  93 DAKLEKLGTSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILCFFNGGQSTISVVY 172
Cdd:cd17315   32 STSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVPLY 111

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 193207761 173 MIENIPKRTRGYISTLISYSpnvILLGIL-------AFFFQQWDRLALVISFLTVPAIIMLA---FLHESPRWLM 237
Cdd:cd17315  112 ISEIAPAKIRGALGTLNQLM---ITFGILlayllglALSLSPPGWWRLMFALAAVPALLQLLlmfFLPESRALLV 183
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
101-445 1.93e-10

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 62.30  E-value: 1.93e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 101 TSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILCFFNGGQSTISVVYMIENIPKR 180
Cdd:COG2814   51 VTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPE 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 181 TRGYISTLISYSPNV------ILLGILAFFFqQWDRLALVISFLTVPAIIMLAFLhesprwlmqkgqishakkvflaiek 254
Cdd:COG2814  131 RRGRALGLLGAGLGLgpalgpLLGGLLADLF-GWRWVFLVNAVLALLALLLLLRL------------------------- 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 255 fdgVPAAKSLNETELenflenehdkqvadgntevgkQHSFWHLFKTKEIMTGTFVIAFTFFATTLINYSI------MFNL 328
Cdd:COG2814  185 ---LPESRPAARARL---------------------RGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLplylqeVLGL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 329 GAVAGSIYMnsILIGLLRYSFSLFSGLLdykFEKFDRKmchgicSVVTISIIVAIIAFCLTDTTATFSVLIrIGVLLSCA 408
Cdd:COG2814  241 SASAAGLLL--ALFGLGGVLGALLAGRL---ADRFGRR------RLLLIGLLLLALGLLLLALAGSLWLLL-LALFLLGF 308

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 193207761 409 MTSQAIIVASIASNELMPTAIRSISYSTAQLCSRFGI 445
Cdd:COG2814  309 GFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
xylE PRK10077
D-xylose transporter XylE; Provisional
 109-495 8.72e-10

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 60.86  E-value: 8.72e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 109 MLGCVVFGQIG----DQYGRKTPMMFCLCMCFIfgimSALSADFKKFTIFR------TILCFFN-----GG-----QSTI 168
Cdd:PRK10077  65 LIGCIIGGALGgycsNRFGRRDSLKIAAVLFFI----SALGSAWPEFGFTSigpdntGYVPEFViyriiGGigvglASML 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 169 SVVYMIENIPKRTRGyisTLISYSPNVILLGILAFFFQQW-----DRLALVIS------FLT--VPAIIMLAFLH---ES 232
Cdd:PRK10077 141 SPMYIAEIAPAHIRG---KLVSFNQFAIIFGQLVVYFVNYfiarsGDASWLNTdgwrymFASeaIPALLFLMLLYfvpET 217

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 233 PRWLMQKGQISHAKKVflaIEKFDGVPAAKslneTELENFlenehdKQVAD-GNTEVGKQHSFWHLFKTKEIMTGTFVIA 311
Cdd:PRK10077 218 PRYLMSRGKQEQAEGI---LRKIMGNTLAT----QALQEI------KHSLDhGRKTGGKLLMFGVGVIVIGVMLSVFQQF 284

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 312 FTFFATTLINYSIMFNLGAVAGSIYMNSILIGLLRYSFSLfsgLLDYKFEKFDRKMChgicsVVTISIIVAIIAFCLTdt 391
Cdd:PRK10077 285 VGINVVLYYAPEIFKTLGASTDIALLQTIIVGVINLTFTV---LAIMTVDKFGRKPL-----QIIGALGMAIGMFSLG-- 354

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 392 TATFSVLIRIGVLLSC-------AMTSQAIIVASIAsnELMPTAIRSISYSTA---QLCSRFGIVFAPHVFHLNLYTGID 461
Cdd:PRK10077 355 TAFYTQAPGIVALLSMlfyvaafAMSWGPVCWVLLS--EIFPNAIRGKALAIAvaaQWIANYFVSWTFPMMDKNSWLVAH 432

                        410       420       430
                 ....*....|....*....|....*....|....*
gi 193207761 462 F-PVLPYAILLAIGLADFIFFRFLIPETKNKPLED 495
Cdd:PRK10077 433 FhNGFSYWIYGCMGVLAALFMWKFVPETKGKTLEE 467
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 99-481 3.53e-09

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 58.59  E-value: 3.53e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  99 LGTSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILCFFNGGQSTISVVYMIENIP 178
Cdd:cd06174   35 LLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFP 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 179 KRTRGYISTLISYSPNV-------ILLGILAFFFQQWDRLALVISFLTVPAIIMLAFLHESPRWLMQKGQISHAKKVFLa 251
Cdd:cd06174  115 ERERGRALGLLQAFGSVggilgplLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVL- 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 252 iekfdgvpaakslnetelenflenehdkqvadgntevgkqHSFWHLFKTKeimtGTFVIAFTFFATTLINYSIMFNLGAV 331
Cdd:cd06174  194 ----------------------------------------KLLKRVLKNP----GLWLLLLAIFLVNLAYYSFSTLLPLF 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 332 AGSIYMNSILIGLLRYSFSLFSGLLDYKFEKFDRKMCHGICSVVTISIIVAIIAFCLTDTTATFSVLIRIGVLLSCAMTS 411
Cdd:cd06174  230 LLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGG 309

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 412 QAIIVASIASnELMPTAIRSISYSTAQLCSRFGIVFAPHVFHLNLYTGIDFPVLPYAILLAIGLADFIFF 481
Cdd:cd06174  310 LLPLSFALIA-ELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 97-238 5.64e-09

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 57.93  E-value: 5.64e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  97 EKLGTSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILCFFNGGQSTISVVYMiEN 176
Cdd:cd17372   36 VALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLVGLGLGGGPQLASWYL-EF 114

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 193207761 177 IPKRTRGYISTLIS--YSPNVILLGILAFFFQQWDRLALVISFLTVPAIIMLAFLHESPRWLMQ 238
Cdd:cd17372  115 LPAKSRGTWMVLFSvfWTVGTIFEASLAWLVMPRLGWRWLLAFSSVPSSLLLVFYRWTPKTTLL 178
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 102-245 1.15e-08

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 57.68  E-value: 1.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  102 SIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILCFFNGGQSTISVVYMIENIPKRT 181
Cdd:TIGR01299 209 LIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEK 288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  182 RG-YISTLISY------SPNVILLGIL-----------AFFFQQWDRLALVISFLTVPAIIMLAFLHESPRWLMQKGQIS 243
Cdd:TIGR01299 289 RGeHLSWLCMFwmiggiYAAAMAWAIIphygwsfqmgsAYQFHSWRVFVIVCAFPCVFAIGALTFMPESPRFFLENGKHD 368


                  ..
gi 193207761  244 HA 245
Cdd:TIGR01299 369 EA 370
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
 76-220 1.82e-08

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 56.32  E-value: 1.82e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  76 FERQFY--GITEQFKLLCEDAKLEKLGTSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTI 153
Cdd:cd17376   14 YSQDVYlsTIVTEWNLVCEDDWKVPLTTSLFFVGVLLGSFISGQLSDRFGRKKVLFATMAVQTGFSFLQIFSPSWEMFTV 93

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 154 FRTILCFFNGGQSTISVVYMIENIPKRTRGYISTL---ISYSPNVILLGILAFFFQQWDRLALVISFLTV 220
Cdd:cd17376   94 LFVIVGMGQISNYVVAFVLGTEILGKSVRILFSTLgvcIFYAIGYMLLPLFAYFIRDWRMLLLALTLPGV 163
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 105-237 4.56e-08

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 54.82  E-value: 4.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 105 MLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILCFFNGGQSTISVVYMIENIPKRTRGY 184
Cdd:COG0477   59 LLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGR 138

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 193207761 185 ISTLISYSPNV-ILLG-ILAFFFQQWD--RLALVIS-FLTVPAIIMLAFLHESPRWLM 237
Cdd:COG0477  139 ALGLWGAAIGLgLALGpLLGGLLVAALgwRWIFLINaPLGLLALVLRLRLPESRGLLL 196
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 101-236 1.55e-07

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 53.41  E-value: 1.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 101 TSIQMLGVMLGCVVFGQIGDQYGRKTPMMFClCMCFIFGIMSALSADFKKFTIF--RTILCFFNGGQSTISVVYMIENIP 178
Cdd:cd17356   51 VSIVNLGSFFGALISSFLSDRIGRKKSIQIG-CVIYIIGAIIQVAAIGKWYQLIvgRIIAGLGVGFASVLVPVYQSEVAP 129

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 193207761 179 KRTRGyisTLISYSPNVILLGIL-AFF----------FQQWdRLALVISFltVPAIIMLA---FLHESPRWL 236
Cdd:cd17356  130 KHIRG---TLVSLYQLAITIGILvAYCinygthkldgSAQW-RIPLGLQI--VWGLLLLIgmfFLPESPRWL 195
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
 102-241 2.26e-07

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 53.26  E-value: 2.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 102 SIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILCFFNGGQSTISVVYMIENIPKRT 181
Cdd:cd17363   41 LIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGFFLFCRLLSGIGIGGSIPIVFSYFAEFLAREK 120

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 193207761 182 RG-YISTLISY------SPNVILLGIL-----------AFFFQQWDRLALVISFLTVPAIIMLAFLHESPRWLMQKGQ 241
Cdd:cd17363  121 RGeHLSWLCMFwmigglYASAMAWAIIphygwgfsmgtAYQFHSWRVFVIVCALPSVASVVALTFMPESPRFLLEVGK 198
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
 102-245 2.59e-07

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 52.99  E-value: 2.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 102 SIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILCFFNGGQSTISVVYMIENIPKRT 181
Cdd:cd17440   41 SIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQGYGLFLFCRLLSGFGIGGAVPTVFSYFAEVLAREK 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 182 RG---------------YISTL----ISYSPNVILLGIlAFFFQQWDRLALVISFLTVPAIIMLAFLHESPRWLMQKGQI 242
Cdd:cd17440  121 RGehlswlcmfwmiggiYASAMawaiIPHYGWSFSMGS-AYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKH 199


                 ...
gi 193207761 243 SHA 245
Cdd:cd17440  200 DEA 202
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 102-495 4.26e-07

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 52.19  E-value: 4.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 102 SIQMLGVMLGCVVFGQIGDQYGRKTPMMFClCMCFIFGIMSALSA-DFKKFTIFRTILCFFNGGQSTISVVYMIENIPKR 180
Cdd:cd17433   48 SVVTLGAAAGGVLGGWIVDRAGRKLSLMLC-SVPFIAGFTVITAAqNVWMLYVGRLLTGLASGVTSLVVPVYISEIAHPR 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 181 TRGYISTLISYSPNV-ILLGILAFFFQQWDRLALVISFLTVPAIIMLAFLHESPRWLMQKGQISHAKKVFLAIEKFDgVP 259
Cdd:cd17433  127 VRGTLGSCVQLMVVIgIMGAYLAGLVLDWRWLAVLGSIPPTLMLLLMCFMPETPRFLLTQHRRQEAMAALRFLRGPD-QG 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 260 AAKSLNETElENFLENEHDKQVAD-GNTEVGKQHSFWHLFKTKEIMTGtfVIAFTFFATTLINYSiMFNLGAVAgsiymn 338
Cdd:cd17433  206 WEWECIGIE-QSFHLEEQSFSLALlKQPGIYKPLIIGVSLMAFQQLTG--INAVMFYAETIFEEA-KFKDSSVA------ 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 339 SILIGLLRYSFSLFSGLLdykFEKFDRKMchgicsVVTISIIVAIIafcltdTTATFSVLirigvllscAMTSQAIIVAS 418
Cdd:cd17433  276 SVIVAAIQVLFTAVAALI---MDRAGRKV------LLVLSGVVMVF------STAAFGWL---------AVGSMGFFIAG 331

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 419 IA----------SNELMPTAIRSISYSTAQLCSRFGIVFAPHVFHlNLyTGIDFPVLPYAILLAIGLADFIFFRFLIPET 488
Cdd:cd17433  332 FAvgwgpipwlvMSEIFPLHVRGVASGICVLTNWLMAFLVTKEFS-SL-MEVLSSYGTFWLFSAFCAFSVLFTLFCVPET 409


                 ....*..
gi 193207761 489 KNKPLED 495
Cdd:cd17433  410 KGKTLEQ 416
MFS_1 pfam07690
Major Facilitator Superfamily;
101-449 6.68e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 51.26  E-value: 6.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  101 TSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILCFFNGGQSTISVVYMIENIPKR 180
Cdd:pfam07690  38 LTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPE 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  181 TR----GYISTLISYSPNV--ILLGILAFFFQqWDRLALVISFLTVPAIIMLAFLHESPRWLMQKGQISHAKKVFLAIEK 254
Cdd:pfam07690 118 ERgralGLVSAGFGLGAALgpLLGGLLASLFG-WRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKA 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  255 FDGVPAAKslnetelenflenehdkqvadgntevgkqhsfwhlfktkeIMTGTFVIAFTFFA--TTLINYSIMFNLGAVA 332
Cdd:pfam07690 197 LLRDPVLW----------------------------------------LLLALLLFGFAFFGllTYLPLYQEVLGLSALL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  333 GSIYMNsiLIGLLRYSFSLFSGLLdykfekFDRKMCHGICSVVTISIIVAIIAFCLTDTTATFSVLIRIGVLLSCAMTSQ 412
Cdd:pfam07690 237 AGLLLG--LGGLLGAIGRLLLGRL------SDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLV 308

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 193207761  413 AIIVASIASnELMPTAIRSISYSTAQLCSRFGIVFAP 449
Cdd:pfam07690 309 FPALNALVS-DLAPKEERGTASGLYNTAGSLGGALGP 344
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
99-489 7.98e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 51.02  E-value: 7.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  99 LGTSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILCFFNGGQSTISVVYMIENIP 178
Cdd:COG2271   49 LLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFP 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 179 KRTRGYISTLISYSPNV---ILLGILAFFFQQWD-RLALVIsfLTVPAIIMLAFlhesprwlmqkgqishakkvflaiek 254
Cdd:COG2271  129 PKERGRALGIFNAGGPLggaLAPPLLGWLLAAFGwRAAFLI--LGLPGLLLALL-------------------------- 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 255 fdgvpaakslnetelenflenehdkqvadgntevgkqhSFWHLFktkeIMTGTFVIAFTFFATTLINY-SIMFNLGAVAG 333
Cdd:COG2271  181 --------------------------------------RFWLLA----LAYFLVYFALYGFLTWLPTYlVEVRGLSLAQA 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 334 SIYMnsILIGLLRYSFSLFSGLLdykFEKFDRKMCHGICSVVTISIIVAIIAFCLTDTTATFSVLIRIGVLLSCAMTSQA 413
Cdd:COG2271  219 GLLL--SLPFLAGIVGSLLGGWL---SDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLW 293

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 193207761 414 IIVAsiasnELMPTAIRSISYSTAQLCSRFGIVFAPHVF-HLNLYTGIDFPVLPYAILLAIGLadfIFFRFLIPETK 489
Cdd:COG2271  294 ALAA-----ELFPKKARGTASGLVNTFGFLGGALGPLLVgYLLDATGYQAAFLLLAALALLAA---LLALLLLRETR 362
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 99-229 1.18e-06

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 50.63  E-value: 1.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  99 LGTSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILCFFNGGQSTISVVYMIENIP 178
Cdd:cd17324   38 LLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVP 117

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 193207761 179 KRTRG-YISTLISYSPNVILLGIL--AFFFQQWD-RLA-LVISFLTVPAIIMLAFL 229
Cdd:cd17324  118 PEKRGrAIGLVFSGLTLGLVLGRPlgGLLGQLLGwRAAfLAIAVLALLAALLLWRL 173
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 102-205 2.73e-06

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 49.51  E-value: 2.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 102 SIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLcmcFIFGIMSALSA---DFKKFTIFRTILCFFNGGQSTISVVYMIENIP 178
Cdd:cd17365   41 SAALFGMAIGALLAGPLADRFGRKRVLLVSV---ALFGLFTLLTAfaqSVLQLALLRFLTGLGLGAAMPNAITLVSEYAP 117

                         90       100
                 ....*....|....*....|....*....
gi 193207761 179 KRTRGYISTLIS--YSPNVILLGILAFFF 205
Cdd:cd17365  118 ARRRSLAVTLMFcgYPLGAALGGFLAAAL 146
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 103-245 3.30e-06

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 49.54  E-value: 3.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 103 IQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILCFFNGGQSTISVVYMIENIPKRTR 182
Cdd:cd17438   42 IVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKR 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 183 G-YISTLISY------SPNVILLGILAFF-----------FQQWDRLALVISFLTVPAIIMLAFLHESPRWLMQKGQISH 244
Cdd:cd17438  122 GeHLSWLCMFwmigglYASAMAWSIIPHYgwgfsmgtnyhFHSWRVFVIICALPCIASIIALKFMPESPRFLLEMGKHDE 201


                 .
gi 193207761 245 A 245
Cdd:cd17438  202 A 202
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 83-235 5.16e-06

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 48.81  E-value: 5.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  83 ITEQFKLLCEDAKLEKLGTSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILCFFN 162
Cdd:cd17360   23 IKDDLGEVVLSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGV 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 163 GGQSTISVVYMIENIPKRTRGYISTL----------ISYSPNvillGILAFFFQQWdRLALVISflTVPAIIMLA---FL 229
Cdd:cd17360  103 GIASMTVPLYIAEAAPPRIRGRLVTInvlfitggqfVAYVIN----GAFSYLPGGW-RWMLGLA--AVPAVLQFIgllFL 175


                 ....*.
gi 193207761 230 HESPRW 235
Cdd:cd17360  176 PESPRW 181
MFS_SLC22A31 cd17443
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ...
 83-155 6.16e-06

Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341001 [Multi-domain]  Cd Length: 343  Bit Score: 48.23  E-value: 6.16e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 193207761  83 ITEQFKLLCEDAKLEKLGTSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFR 155
Cdd:cd17443   24 LVTEWNLVCDDGWKVPLEKISYLLGWLLGYIILGAGCDRLGRRAAFVLSLVLATLLGVSVALSASPPTFLVLR 96
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 102-491 8.27e-06

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 48.38  E-value: 8.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 102 SIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKF--TIFRTILCFFNGGQStISVV--YMIENI 177
Cdd:cd17432   57 SIFPLGGLFGSLLVGPLVIRLGRKGTLLLNNIFAIVAAILMGLSKIAKSFemIIVGRFLVGINAGIS-LNVVpmYLGESA 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 178 PKRTRGYISTlisySPNV-ILLGIL-AFFF---------QQWdrlALVISFLTVPAIIMLA---FLHESPRW-LMQKGQI 242
Cdd:cd17432  136 PKNLRGAVGL----VPAIfITLGILlGQVLglrellgneEGW---PLLLALTGVPALLQLLtlpFFPESPRYlLIEKGDE 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 243 SHAKKvflAIEKFDGvpaaKSLNETELENFLEnEHDKQVADGNtevgkqHSFWHLFKTKEIMTGTFVIAFTFFATTL--- 319
Cdd:cd17432  209 EAARK---ALQRLRG----KEDVDDEMEEMLE-EQRAEKGVGT------VSVLELFRDRSVRWQLISIIVLMAGQQLcgi 274

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 320 --INY---SIMFNLGAVAGSIYMNSILIGLLRYSFSLFSGLLdykFEKFDRKMC----HGICSVVTISIIVAIiafCLTD 390
Cdd:cd17432  275 naIYFyadSIFLEAGIPEDKIQYVTVGTGACEVLATITCVLV---IERLGRRPLliggFGLMAVWCAVLTVAL---SLQN 348

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 391 TTATFSVLirigvllscamtSQAIIVASIASNELMPTAIRSISYST--AQLCSRFGIVFAPHVFHLNLYT-GIDFPVLP- 466
Cdd:cd17432  349 TVSWMPYL------------SIVCIFAYIASFGIGPAGVPFILTTEifDQSSRPAAFMVAGSLNWLSNFLvGLLFPFIQe 416

                        410       420       430
                 ....*....|....*....|....*....|.
gi 193207761 467 ------YAILLAIGLADFIFFRFLIPETKNK 491
Cdd:cd17432  417 glgaycFLVFAVICLLTAIYIFFVLPETKGK 447
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
 83-234 1.07e-05

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 47.74  E-value: 1.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  83 ITEQFKLLCEDAKLEKLGTSIQMLGVMLGCVVFGQIGD-QYGRKtPMMF--CLCMcFIFGIMSALSADFKKFTIFRTILC 159
Cdd:cd17378   21 IVSEWGLICAGSFLVGLPQSSFFVGCLIGSGVLGHLADsSLGRK-NLLFlsCLLM-ALSGIATAFSPNYWVYAFLRFLTG 98

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 193207761 160 FFNGGQSTISVVYMIENIPKRTRGY--ISTLISYSPNVILLGILAFF-FQQWDRLALVISFltvPAIIMLAFLHESPR 234
Cdd:cd17378   99 FGRSGIGTCALVLATEPVGPKWRGQvgMSTFFFFVLGFMSLPGIAYLnGSSWRVLYFWTSI---PALIYCILVYLFAR 173
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
 103-245 1.18e-05

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 47.72  E-value: 1.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 103 IQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILCFFNGGQSTISVVYMIENIPKRTR 182
Cdd:cd17439   42 IVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKR 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 183 G-YISTLISY------SPNVILLGIL-----------AFFFQQWDRLALVISFLTVPAIIMLAFLHESPRWLMQKGQISH 244
Cdd:cd17439  122 GeHLSWLCMFwmiggiYASAMAWAIIphygwsfqmgsAYQFHSWRVFVLVCAFPSVFAIGALTTMPESPRFFLENGKHDE 201


                 .
gi 193207761 245 A 245
Cdd:cd17439  202 A 202
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 101-235 1.31e-05

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 47.35  E-value: 1.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 101 TSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILCFFNGGQSTISVVYMIENIPKR 180
Cdd:cd17362   45 VSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSH 124

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 193207761 181 TRGyisTLISYSPNVILLGILAFFFQQWDRLALV------ISFLTVPAIIM---LAFLHESPRW 235
Cdd:cd17362  125 IRG---LLVSLKELFIVLGILLGYVSGYAFADVVggwrymYGLAAPPALLLgigMWFLPPSPRW 185
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
 99-189 1.41e-05

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 47.11  E-value: 1.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  99 LGTSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILCFFNGGQSTiSVVYMIENIP 178
Cdd:cd17441   38 LLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWILVLRGLVGFGIGGVPQ-SVTLYAEFLP 116

                         90
                 ....*....|.
gi 193207761 179 KRTRGYISTLI 189
Cdd:cd17441  117 MKSRAKCILLI 127
PRK03893 PRK03893
putative sialic acid transporter; Provisional
 110-213 1.53e-05

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 47.38  E-value: 1.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 110 LGCVVFGQIGDQYGRKtPMMFCLCMCFIFG-IMSALSADFKKFTIFRTILCFFNGGQSTISVVYMIENIPKRTRGYIST- 187
Cdd:PRK03893  70 FGGLLLGAMGDRYGRR-LAMVISIVLFSVGtLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGf 148

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 193207761 188 LIS-YSPNVIL-------------------LGILAFFFQQWDRLAL 213
Cdd:PRK03893 149 LISgFSIGAVVaaqvyslvvpvwgwralffIGILPIIFALWLRKNL 194
MFS_SLC22A17_like cd17373
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ...
 86-228 1.70e-05

Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340931 [Multi-domain]  Cd Length: 348  Bit Score: 47.13  E-value: 1.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  86 QFKLLCEDAKLEKLGTSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILCFFNGGQ 165
Cdd:cd17373   16 KWDLVCDNGWKVHLEQFSLLLGLIFGYLILGCIADRFGRRPVLLFSLILILIFGLTVALAVSVTMFSTLRFLEGFCLAGI 95

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 193207761 166 STISVVYMIENIPKRTRGYIS---TLISYSPNVILLGiLAFFFQQWDRLALVIsflTVPAIIMLAF 228
Cdd:cd17373   96 ILTLYLLRLELCDPGKRLMITmvaSLVAVAGQFLMPG-LAALCRDWRVLQALI---ICPFLLMLLY 157
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 96-482 1.04e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 44.49  E-value: 1.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  96 LEKLGTSIQMLGVMLGC---------VVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILCFFNGGQS 166
Cdd:cd17325   23 AESLGASVAQIGLIVAAyalaqllfsPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVW 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 167 TISVVYMIENIPKRTRG-YISTLISYSPNVILLGILA--FFFQQWDRLALVIsFLTVPAIIMLAFlhesprwlmqkgqis 243
Cdd:cd17325  103 PAAMALIADIAPPEERGrAMGIFSSAIGLGFLIGPLLggLLADALGYRAPFL-VCAALALLALVL--------------- 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 244 hakkVFLAIEKFDGVPAAKSlnetelenflenehdkqvadgNTEVGKQHSFWHLFKTKEIMTGTFVIAFTFFATTLINYS 323
Cdd:cd17325  167 ----ALLLLPEPRPPPNKRA---------------------VSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPF 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 324 IMFNLGAVAG-SIYMNSILIGLLRYSFSLFSGLLDYKFEKFDRKMchgicsVVTISIIVAIIAFCLTDTTATFSVLIRIG 402
Cdd:cd17325  222 LPLYAAELGGlSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKP------LILIGLLLSAVALLLLPLATSFWLLLLLL 295

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 403 VLLSCAMTSQAIIVASIASnELMPTAIRSISYSTAQLCSRFGIVFAPHVF-HLNLYTGIDFPVLPYAILLAIGLADFIFF 481
Cdd:cd17325  296 ALLGLGLGLVFPATLALLA-DIVPPEGRGTAMGLFNTAFSLGMVLGPLLGgFLYDAFGFATPFLAAAALLLLAAVLFLLL 374


                 .
gi 193207761 482 R 482
Cdd:cd17325  375 R 375
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 99-419 1.25e-04

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 44.53  E-value: 1.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  99 LGTSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLcmcFIFGIMSALSA---DFKKFTIFRTILCFFNGGQSTISVVYMIE 175
Cdd:cd17328   38 LLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGI---LIWSAATLLSSfapNFWQLLLFRALVGIGEASYSPIAPTIIAD 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 176 NIPKRTRG------YISTLISYSPNVILLGILAFFFQQWdRLALVIS-FLTV-PAIIMLAFLHESPRwlmqkgqiSHAKK 247
Cdd:cd17328  115 LFPKEKRTralgvfYFAIPLGSGLGYVVGGLVAQATGGW-RWAFRVTgVLGVlLAILLLLFVREPPR--------GAAEG 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 248 VFLAIEKFDGVPAAKSlnetelenflenehdkqvadgntEVGKQHSFWHLfkTKEIMTGTFVI-AFTFFATTLINYSIMF 326
Cdd:cd17328  186 GVMAKSTATSFLADLK-----------------------ALAKNPSFILS--TLGFTAVSFVTgALAFWAPTFFLRAFGV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 327 ------NLGAVAGSIYMNSILIGLlrysfsLFSGLLDYKFEKFD---RKMCHGICSVVTISIIVAIIAFCLTDTTATFsV 397
Cdd:cd17328  241 gdlssaDVGLIFGAITCIAGVLGV------LLGGILADRLRRKTpraDPLVCAVGLLAAAPFLFLALVLALSNLLLAW-V 313

                        330       340
                 ....*....|....*....|..
gi 193207761 398 LIRIGVLLSCAmtSQAIIVASI 419
Cdd:cd17328  314 LLFLGEFLLSL--NWAPVFAIL 333
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 101-484 1.79e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 43.74  E-value: 1.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 101 TSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILCFFNGGQSTISVVYMIENIPKR 180
Cdd:cd17489   37 VGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPS 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 181 TRGyisTLISYSPNVILLGI-----LAFFFQQW---DRLALVISFLTVPAIIMLAFLHEsprwlmqkgqishakkvflai 252
Cdd:cd17489  117 RRG---EGIGYYGLATTLAMalgpaLGLFLYQHlgfAVLFIVAAVLALLALLLVFLVKD--------------------- 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 253 ekfdgvpaakslnetelenflenehDKQVADGNTEVGKqhSFWHLFKTKEIM---TGTFVIAFTFFATTLINYSIMFNLG 329
Cdd:cd17489  173 -------------------------PPPVAAEEAEAGT--RAFRRLVEKKVLppaLILFLASIAYGAISTFLPLYAAERG 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 330 AVAGSIYMnsILIGLLRYSFSLFSGLLdykFEKFDRKMchgicsVVTISIIVAIIAFCLTDTTATFSVLIRIGVLLSCAM 409
Cdd:cd17489  226 ISNAGLFF--TVYAIALLLSRPFSGKL---SDRKGPKT------VIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGF 294

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 410 -----TSQAIIVAsiasneLMPTAIRSISYSTAQLCSRFGIVFAPHVFHLnLYTGIDFPVLpYAILLAIGLADFIFFRFL 484
Cdd:cd17489  295 gllfpALQALAVD------LVPPHRRGAANGTFFIFFDLGIGLGGLLLGL-VAELFGYRAM-FLLAAVVVLLALVLYIFL 366
MFS_GLUT12_Class3 cd17435
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 105-239 2.43e-04

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340993 [Multi-domain]  Cd Length: 376  Bit Score: 43.25  E-value: 2.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 105 MLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILCFFNGGQSTISVVYMIENIPKRTRGy 184
Cdd:cd17435   46 LIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVCSVSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRG- 124

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 193207761 185 isTLISYSPNVILLGILAFFFQQWD----------RLALVISFLTVPAIIMLaFLHESPRWLMQK 239
Cdd:cd17435  125 --LLVSLNELMIVIGILLAYISNYAfanvsngwkyMFGLVIPLAALQAIAMY-FLPPSPRFLVMK 186
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 99-228 4.64e-04

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 42.56  E-value: 4.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  99 LGTSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRtilcFFNG---------GQSTIS 169
Cdd:cd17323   38 LGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILR----FLQGffgssplaiGAGTIA 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 170 VVYmieniPKRTRGYISTLISYSPNV----------------------ILLGILAFFFqqwdrlaLVISFLTVPAIIMLA 227
Cdd:cd17323  114 DLF-----TPEERGKAMGVYSLGPLLgpalgpiiggfitqslgwrwifWFLAIISGFC-------LILIFLFLPIVLLLG 181


                 .
gi 193207761 228 F 228
Cdd:cd17323  182 L 182
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 101-228 5.80e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 42.18  E-value: 5.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 101 TSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILCFFNGGQSTI-SVVYMIENIPK 179
Cdd:cd17330   40 QSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVAqAYIADITDEEE 119

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 193207761 180 RTR--GYISTLISYSpnVILLGILAFFFQQWDRLALVISFLTVPAIIMLAF 228
Cdd:cd17330  120 RAKafGIISAAFGLG--FILGPALGGFLSTPYGYALPFLVAAALALLNLVL 168
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 114-484 6.94e-04

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 41.79  E-value: 6.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 114 VFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILCFFNGGQSTISVVyMIENI---PKRTR--GYISTL 188
Cdd:cd17474   53 VAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALT-LIGDLfegGERAKamGLYEAA 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 189 ISYSPNV--ILLGILAFFFQQWdrlalviSFLTVPAIIMLAFLhesprwlmqkgqishakkVFLaiekfdgvpaakslne 266
Cdd:cd17474  132 LGLGIAVgpLLGGLLAAISWRY-------PFFLLAALIPVAFL------------------AIL---------------- 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 267 teleNFLENEHDKQVADGNTEVGKQHSFWHLFKTKEIMTGTFVIAFTFFAttLINY-SIMFNLgavagSIYMNSILIGLL 345
Cdd:cd17474  171 ----FLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFA--FLTYlPFLLEL-----LYGISPIIIGLL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 346 RYSFSLFSGLLDYKFEKF--DRKMCHGICSVVTISIIVAIIAFCLTDTTATFSVLIRI-GVLLSCAMTSQAIIVASIASN 422
Cdd:cd17474  240 FAGWSVLLALGSLFVGRLlkKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLfGLGLGLNLPLLTTLVTELAPE 319

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 193207761 423 ELMPTAIrSIsYSTAQlcsRFGIVFAPHVFHLnLYTGIDFPVlPYAILLAIGLADFIFFRFL 484
Cdd:cd17474  320 EERGTAS-SL-YNFVR---FLGQAVGPLLFGL-LLEIFGLSA-PFLVGAAIALAAAVLLALL 374
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
 106-261 7.55e-04

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 41.88  E-value: 7.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 106 LGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKK------FTIFRTILCFFNGGQSTISVVYMIENIPK 179
Cdd:cd17364   50 VGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGSTPlgvmgwLIFFRFLLGIGIGGDYPLSATIMSEYANK 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 180 RTRGyistlisyspnvillGILAFFFQQWDRLALVISFLTVpaIIMLAFLHESPRwlmqkGQISHAKKVFLAIEKFDGVP 259
Cdd:cd17364  130 KRRG---------------ALIAAVFAMQGFGILAGAIVTL--ILSAIFEHPLPA-----GTYHHADLVWRIVLGLGAIP 187


                 ..
gi 193207761 260 AA 261
Cdd:cd17364  188 AL 189
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 101-256 3.06e-03

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 39.98  E-value: 3.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 101 TSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILCFFNGGQSTISVVYMIENIPKR 180
Cdd:cd17371   40 GTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPAR 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 181 TRGYISTLI--SYSPNVILLGILAFFFQQW--DRLALVISFLT--VPAIIMLA---FLHESPRWLMQKGQISHAKKVFLA 251
Cdd:cd17371  120 HRGKALGYVqsGWAVGWLLATLLAALLFPLlpPEIAWRVLFLLgaLPALLVLFirrFVKEPPQWQAARAARRHFADRPSL 199


                 ....*
gi 193207761 252 IEKFD 256
Cdd:cd17371  200 RELFS 204
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
99-190 3.21e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 39.96  E-value: 3.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  99 LGTSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILCFFNGGQSTISVVYMIENIP 178
Cdd:COG2814  247 LLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAP 326

                         90
                 ....*....|..
gi 193207761 179 KRTRGYISTLIS 190
Cdd:COG2814  327 PEARGRASGLYN 338
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 102-148 3.40e-03

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 39.95  E-value: 3.40e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 193207761 102 SIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADF 148
Cdd:PRK11551  57 SAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDF 103
MFS_SLC22A23 cd17444
Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier ...
 83-234 3.41e-03

Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier family 22, member 23 (SLC22A23) is an orphan member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It is abundantly expressed in brain and is also found in liver. Single-nucleotide polymorphisms in SLC22A23 are associated with inflammatory bowel disease (IBD) in a Canadian white population. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A23 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341002 [Multi-domain]  Cd Length: 364  Bit Score: 39.83  E-value: 3.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  83 ITEQFKLLCEDAKLEKLGTSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRTILCFFN 162
Cdd:cd17444   24 IVSKWDLVCDSSWKVHIAKFSLLVGLIFGYLITGCLADWFGRRPVLLFSVVFILIFGLTVALSVNVTMFSTLRFFEGFCL 103

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 193207761 163 GGQSTISVVYMIENIPKRTRGYISTLISY--SPNVILLGILAFFFQQWDRLALVIsflTVPAIIMLAFLHESPR 234
Cdd:cd17444  104 AGIILSLYALRIELCPPGHRFMITMVASFiaMAGQFLMPGLAALCRDWQVLQAVI---ICPFLLMLSYWCIFPK 174
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 99-248 5.49e-03

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 39.24  E-value: 5.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761  99 LGTSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIF---RTILCFFNGGQSTISVVYMIE 175
Cdd:cd17431   54 LSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLYNNLLAFAGAALMGLSKLAKSYEMLilgRFIIGLYCGLTTGLVPMYIGE 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207761 176 NIPKRTRGYISTLISYSpnvILLGILA-------FFFQQWDRLALVISFLTVPAI---IMLAFLHESPRWLM-QKGQISH 244
Cdd:cd17431  134 ISPTALRGALGTLHQLG---IVVGILIsqifgleFILGTEELWPLLLGFTIVPAIlqlALLPFCPESPRYLLiNRNEEEE 210


                 ....
gi 193207761 245 AKKV 248
Cdd:cd17431  211 AKSV 214
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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