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Conserved domains on  [gi|193206179|ref|NP_001122773|]
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tRNA methyltransferase 10 homolog A [Caenorhabditis elegans]

Protein Classification

tRNA methyltransferase 10 homolog A( domain architecture ID 13031076)

tRNA methyltransferase 10 homolog A (TRMT10A) is a S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs

EC:  2.1.1.221
Gene Symbol:  TRMT10A
Gene Ontology:  GO:0008033
PubMed:  17338813|30457841

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Trm10euk_A cd18101
eukaryotic tRNA m1G9 methyltransferase Trm10 homolog A; Eukaryotic tRNA m1G9 methyltransferase ...
 86-259 1.09e-94

eukaryotic tRNA m1G9 methyltransferase Trm10 homolog A; Eukaryotic tRNA m1G9 methyltransferase Trm10 homolog A (TM10A) catalyzes the N(1) methylation of guanine at Position 9 (m(1)G9) of tRNA, which might play a role in the stabilization of tRNA and in translation termination efficiency. Trm10 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


:

Pssm-ID: 349974  Cd Length: 174  Bit Score: 277.18  E-value: 1.09e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206179  86 QRIALDMSFDDLMIEKDQKRTVQQIGWCYTANRHSPDPFQFHVVGFDGPSRKIYDGNEHNLNQDIHLHQEKLENLFKPEE 165
Cdd:cd18101    1 IRVAIDCSFDDLMTEKDIKKLVKQIQRCYAENRRADNPVQLYLTSLGGKTKENMEKDKGYENWDVNFKEEHYLEVFKKED 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206179 166 IVYLTSESENVLSDLDDTKVYVIGGIVDHNSQKGLCYRIAQEKGFGHAKLPLDEHLLMKSRRVLTINQVYEILVHYSVHK 245
Cdd:cd18101   81 IVYLTSDSPNVLEDLDEDKVYIIGGLVDHNHHKGLCYKRAVELGIQHARLPIDEYVKMKTRKVLTINHVFEILLRYTEGK 160

                        170
                 ....*....|....
gi 193206179 246 NWKDALLSIIPERK 259
Cdd:cd18101  161 DWKEAFFKVIPQRK 174
 
Name Accession Description Interval E-value
Trm10euk_A cd18101
eukaryotic tRNA m1G9 methyltransferase Trm10 homolog A; Eukaryotic tRNA m1G9 methyltransferase ...
 86-259 1.09e-94

eukaryotic tRNA m1G9 methyltransferase Trm10 homolog A; Eukaryotic tRNA m1G9 methyltransferase Trm10 homolog A (TM10A) catalyzes the N(1) methylation of guanine at Position 9 (m(1)G9) of tRNA, which might play a role in the stabilization of tRNA and in translation termination efficiency. Trm10 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349974  Cd Length: 174  Bit Score: 277.18  E-value: 1.09e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206179  86 QRIALDMSFDDLMIEKDQKRTVQQIGWCYTANRHSPDPFQFHVVGFDGPSRKIYDGNEHNLNQDIHLHQEKLENLFKPEE 165
Cdd:cd18101    1 IRVAIDCSFDDLMTEKDIKKLVKQIQRCYAENRRADNPVQLYLTSLGGKTKENMEKDKGYENWDVNFKEEHYLEVFKKED 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206179 166 IVYLTSESENVLSDLDDTKVYVIGGIVDHNSQKGLCYRIAQEKGFGHAKLPLDEHLLMKSRRVLTINQVYEILVHYSVHK 245
Cdd:cd18101   81 IVYLTSDSPNVLEDLDEDKVYIIGGLVDHNHHKGLCYKRAVELGIQHARLPIDEYVKMKTRKVLTINHVFEILLRYTEGK 160

                        170
                 ....*....|....
gi 193206179 246 NWKDALLSIIPERK 259
Cdd:cd18101  161 DWKEAFFKVIPQRK 174
tRNA_m1G_MT pfam01746
tRNA (Guanine-1)-methyltransferase; This is a family of tRNA (Guanine-1)-methyltransferases EC: ...
 96-259 5.22e-39

tRNA (Guanine-1)-methyltransferase; This is a family of tRNA (Guanine-1)-methyltransferases EC:2.1.1.31. In E.coli K12 this enzyme catalyzes the conversion of a guanosine residue to N1-methylguanine in position 37, next to the anticodon, in tRNA.


Pssm-ID: 396350  Cd Length: 182  Bit Score: 135.17  E-value: 5.22e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206179   96 DLMIEKDQKRTVQQIGWCYTANRHSPDPFQFHVVGFD--GPSRKIYDGNE-------HNLN---QDIHLHQEKLENLFKP 163
Cdd:pfam01746   1 GLAQEKGLVSLVVQNLRDYTANRRNTVDDEPYGGGFGmvLKPEPEFEALEsvnyekwKVILltpTGKPFFQEGAVDLSQK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206179  164 EEIVYLTSESENVLSDLDDTKVYVIGGIVDHNSQKGL----CYRIAQEKGFGHAKLPLDEHLLMKS--RRVLTINQVYEI 237
Cdd:pfam01746  81 EHLVYLCGDYEGVDERVDDDKEYSIGDFVDKGGEKGAlvliDLVKRLLPGVLTASLPIDSFLLEKPhyTRPLTLNQVPEI 160

                         170       180
                  ....*....|....*....|..
gi 193206179  238 LVHYSVHKNWKDALLSIIPERK 259
Cdd:pfam01746 161 LLSGNHIRNWKEALLRTIPRRK 182
 
Name Accession Description Interval E-value
Trm10euk_A cd18101
eukaryotic tRNA m1G9 methyltransferase Trm10 homolog A; Eukaryotic tRNA m1G9 methyltransferase ...
 86-259 1.09e-94

eukaryotic tRNA m1G9 methyltransferase Trm10 homolog A; Eukaryotic tRNA m1G9 methyltransferase Trm10 homolog A (TM10A) catalyzes the N(1) methylation of guanine at Position 9 (m(1)G9) of tRNA, which might play a role in the stabilization of tRNA and in translation termination efficiency. Trm10 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349974  Cd Length: 174  Bit Score: 277.18  E-value: 1.09e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206179  86 QRIALDMSFDDLMIEKDQKRTVQQIGWCYTANRHSPDPFQFHVVGFDGPSRKIYDGNEHNLNQDIHLHQEKLENLFKPEE 165
Cdd:cd18101    1 IRVAIDCSFDDLMTEKDIKKLVKQIQRCYAENRRADNPVQLYLTSLGGKTKENMEKDKGYENWDVNFKEEHYLEVFKKED 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206179 166 IVYLTSESENVLSDLDDTKVYVIGGIVDHNSQKGLCYRIAQEKGFGHAKLPLDEHLLMKSRRVLTINQVYEILVHYSVHK 245
Cdd:cd18101   81 IVYLTSDSPNVLEDLDEDKVYIIGGLVDHNHHKGLCYKRAVELGIQHARLPIDEYVKMKTRKVLTINHVFEILLRYTEGK 160

                        170
                 ....*....|....
gi 193206179 246 NWKDALLSIIPERK 259
Cdd:cd18101  161 DWKEAFFKVIPQRK 174
SPOUT_Trm10-like cd18089
tRNA methyltransferase Trm10-like; Family of tRNA methyltransferase Trm10-like proteins ...
 86-254 2.73e-70

tRNA methyltransferase Trm10-like; Family of tRNA methyltransferase Trm10-like proteins catalyzes the N(1) methylation of guanine at position 9 (m(1)G9) of tRNA (eukaryotes) or N(1) methylation of guanine or adenine at position 9 (m1G9/m1A9) of tRNA (archaea), which might play a role in the stabilization of tRNA and in translation termination efficiency. Trm10 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349962  Cd Length: 171  Bit Score: 215.09  E-value: 2.73e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206179  86 QRIALDMSFDDLMIEKDQKRTVQQIGWCYTANRHSPDPFQFHVVGFDGP--SRKIYDGNEHNLNQDIHLHQEKLENLFKP 163
Cdd:cd18089    1 PRIVIDLSFDDLMTEKEIRSLAKQLSRCYGANRRSEKPLRLHLTSFSGDlkQRLLKKSGAENWKIITHEESLLEEEAFPK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206179 164 EEIVYLTSESENVLSDLDDTKVYVIGGIVDHNSQKGLCYRIAQEKGFGHAKLPLDEHLLMKSRRVLTINQVYEILVHYSV 243
Cdd:cd18089   81 EKLVYLTADAEEVLEELDPDKVYIIGGIVDRNRHKGLTLNKAEELGIRTARLPIREYIKLKGRKVLTVNHVFEILLRYLE 160

                        170
                 ....*....|.
gi 193206179 244 HKNWKDALLSI 254
Cdd:cd18089  161 GGDWKEALEEV 171
Trm10euk_B cd18100
eukaryotic tRNA m1G9 methyltransferase Trm10 homolog B; Eukaryotic tRNA m1G9 methyltransferase ...
 86-259 2.11e-51

eukaryotic tRNA m1G9 methyltransferase Trm10 homolog B; Eukaryotic tRNA m1G9 methyltransferase Trm10 homolog B (TM10B) catalyzes the N(1) methylation of guanine at Position 9 (m(1)G9) of tRNA, which might play a role in the stabilization of tRNA and in translation termination efficiency. Trm10 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349973  Cd Length: 182  Bit Score: 167.05  E-value: 2.11e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206179  86 QRIALDMSFDDLMIEKDQKRTVQQIGWCYTANRHSPDPFQFHVVGFDgPSRKIY-------DGNEHNLnqdIHLHQEKLE 158
Cdd:cd18100    1 LRVCIDLSLEHKMSEKEISKLAQQLRRLYGSNRKAEKPLHIYLTSFD-KEGLLYkecvrknDGFENYL---IDMTEESHS 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206179 159 NLFKPEEIVYLTSESENVLSDLDDTKVYVIGGIVDHNSQKGLCYRIAQEKGFGHAKLPLDEHLLMKSR-----RVLTINQ 233
Cdd:cd18100   77 ELFPKEEIVYLSPDSENVLESIDPNKVYVIGGLVDESIQKKLTLQKAKEHGIQTARLPIDEYMVKADGkgnysTVLAINQ 156

                        170       180
                 ....*....|....*....|....*.
gi 193206179 234 VYEILVHYSVHKNWKDALLSIIPERK 259
Cdd:cd18100  157 VFDILLKYYETGDWREALSAGVPQRK 182
Trm10_MRRP1 cd18102
Mitochondrial ribonuclease P protein 1; Mitochondrial ribonuclease P protein 1 (or tRNA ...
 86-258 9.33e-48

Mitochondrial ribonuclease P protein 1; Mitochondrial ribonuclease P protein 1 (or tRNA methyltransferase 10 homolog C) functions in mitochondrial tRNA maturation and is part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. MRRP1 is related to Trm10, a tRNA m1G9 methyltransferase and is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349975  Cd Length: 179  Bit Score: 157.70  E-value: 9.33e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206179  86 QRIALDMSFDDLMIEKDQKRTVQQIGWCYTANRHSPDPFQFHVVGFDGPSRKIYDGNEHNLNQD-----IHLHQEKLENL 160
Cdd:cd18102    1 QPLVIDMSYEDLMSPREIKNTARQLLEAYSANRRSTEPFHLHFCNLDPDGESIKRLLRLIPKLSldkfpITVTEKSYLDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206179 161 FKPEEIVYLTSESENVLSDLDDTKVYVIGGIVDHNSQKGLCYRIAQEKGFGHAKLPLDEHLLMK-SRRVLTINQVYEILV 239
Cdd:cd18102   81 FPKEKLVYLSPDAPEVLKEFDPDKVYIIGGLVDKSTKKPLSLAKAKKEGIRMARLPLDRYLKWGgGSKSLTLNQVVSILL 160

                        170
                 ....*....|....*....
gi 193206179 240 HYSVHKNWKDALLSIIPER 258
Cdd:cd18102  161 DLKDTGDWKEALKHVPPRK 179
tRNA_m1G_MT pfam01746
tRNA (Guanine-1)-methyltransferase; This is a family of tRNA (Guanine-1)-methyltransferases EC: ...
 96-259 5.22e-39

tRNA (Guanine-1)-methyltransferase; This is a family of tRNA (Guanine-1)-methyltransferases EC:2.1.1.31. In E.coli K12 this enzyme catalyzes the conversion of a guanosine residue to N1-methylguanine in position 37, next to the anticodon, in tRNA.


Pssm-ID: 396350  Cd Length: 182  Bit Score: 135.17  E-value: 5.22e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206179   96 DLMIEKDQKRTVQQIGWCYTANRHSPDPFQFHVVGFD--GPSRKIYDGNE-------HNLN---QDIHLHQEKLENLFKP 163
Cdd:pfam01746   1 GLAQEKGLVSLVVQNLRDYTANRRNTVDDEPYGGGFGmvLKPEPEFEALEsvnyekwKVILltpTGKPFFQEGAVDLSQK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206179  164 EEIVYLTSESENVLSDLDDTKVYVIGGIVDHNSQKGL----CYRIAQEKGFGHAKLPLDEHLLMKS--RRVLTINQVYEI 237
Cdd:pfam01746  81 EHLVYLCGDYEGVDERVDDDKEYSIGDFVDKGGEKGAlvliDLVKRLLPGVLTASLPIDSFLLEKPhyTRPLTLNQVPEI 160

                         170       180
                  ....*....|....*....|..
gi 193206179  238 LVHYSVHKNWKDALLSIIPERK 259
Cdd:pfam01746 161 LLSGNHIRNWKEALLRTIPRRK 182
Trm10arch cd18099
archaeal tRNA(m1G9/m1A9)-methyltransferase Trm10; Archaeal tRNA(m1G9/m1A9)-methyltransferase ...
 87-238 4.82e-06

archaeal tRNA(m1G9/m1A9)-methyltransferase Trm10; Archaeal tRNA(m1G9/m1A9)-methyltransferase Trm10 catalyzes the N(1) methylation of guanine or adenine at position 9 (m1G9/m1A9) of tRNA, which might play a role in the stabilization of tRNA and in translation termination efficiency. Trm10 is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.


Pssm-ID: 349972  Cd Length: 170  Bit Score: 45.85  E-value: 4.82e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206179  87 RIALDMSFDDLMIEKDQKRTVQQIGWCYTANRHSPDPFQFHVVG----FDGPSRKIYDGNEHNlnqdiHLHQEKLENlfk 162
Cdd:cd18099    2 YFIIDLSLWDLHTEKEKKKLVLQVLLSIGVIRKYLWDGNLVLTWansmFLEMLNKVESLSLYT-----VGLKEKGED--- 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193206179 163 peEIVYLTSESENVLS--DLDDTKVYVIGGIVDHN-SQKGLCYRIAQEkgfghaklpLDEHLLMKSRRVL---------- 229
Cdd:cd18099   74 --NAVLLDPYAEEVATedIIRDTKAFIIGGIVDKGgNKKGATTELGEL---------LGGAIEVPRRKIVlrgsivgvpd 142


                 ....*....
gi 193206179 230 TINQVYEIL 238
Cdd:cd18099  143 RINKILEII 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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