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Conserved domains on  [gi|193205700|ref|NP_001122692|]
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DNA polymerase kappa [Caenorhabditis elegans]

Protein Classification

Y-family DNA polymerase( domain architecture ID 10132427)

Y-family DNA polymerase similar to DNA polymerase IV which is a poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis

CATH:  3.30.1490.100|3.30.70.270|2.30.40.20|1.10.150.810
EC:  2.7.7.7
Gene Ontology:  GO:0006281|GO:0003684|GO:0006260|GO:0046872|GO:0003887
PubMed:  15680965|24716551|20123134
SCOP:  4000563|4000558

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PolY_Pol_IV_kappa cd03586
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ...
 86-473 1.89e-128

DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.


:

Pssm-ID: 176459 [Multi-domain]  Cd Length: 334  Bit Score: 380.33  E-value: 1.89e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700  86 VCIDMDAYFAAVEMRDNPALRTVPMAVGSS---AMLSTSNYLARRFGVRAGMPGFISNKLCPSLTIVPGNYPKYTKVSRQ 162
Cdd:cd03586    1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSsdrGVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYREVSRQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 163 FSQIFMEYDSDVGMMSLDEAFIDLTDYVASNTEKktfkrhrfggdcpcwlprfdenentledlkieesicpkceksrkiy 242
Cdd:cd03586   81 IMEILREYTPLVEPLSIDEAYLDVTDYVRLFGSA---------------------------------------------- 114

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 243 ydhvefgtgrEEAVREIRFRVEQLTGLTCSAGIASNFMLAKICSDLNKPNGQYVLenDKNAIMEFLKDLPIRKVGGIGRV 322
Cdd:cd03586  115 ----------TEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNKPNGLTVI--PPEDVEEFLAPLPVRKIPGVGKV 182

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 323 CEAQLKAMDIQTVGDMNLKKNLYPLCFTPLSQESFLRTALGLPGRPSESDPRRKSISVERTFSP-TSDFNILLEEHQEIC 401
Cdd:cd03586  183 TAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDRERKSIGVERTFSEdLTDPEELLEELLELA 262

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 193205700 402 RMLEEDVRKSGiVGGKTVTLKLKLSSFDVLTRSLTPSDVVKSLEDIQKFSLELLEKEK-GKEIRLLGVRLSQL 473
Cdd:cd03586  263 EELAERLRKRG-LKGRTVTVKLKYADFSTRTRSRTLPEPTDDAEDIYELALELLEELLdGRPIRLLGVRLSGL 334
 
Name Accession Description Interval E-value
PolY_Pol_IV_kappa cd03586
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ...
 86-473 1.89e-128

DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.


Pssm-ID: 176459 [Multi-domain]  Cd Length: 334  Bit Score: 380.33  E-value: 1.89e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700  86 VCIDMDAYFAAVEMRDNPALRTVPMAVGSS---AMLSTSNYLARRFGVRAGMPGFISNKLCPSLTIVPGNYPKYTKVSRQ 162
Cdd:cd03586    1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSsdrGVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYREVSRQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 163 FSQIFMEYDSDVGMMSLDEAFIDLTDYVASNTEKktfkrhrfggdcpcwlprfdenentledlkieesicpkceksrkiy 242
Cdd:cd03586   81 IMEILREYTPLVEPLSIDEAYLDVTDYVRLFGSA---------------------------------------------- 114

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 243 ydhvefgtgrEEAVREIRFRVEQLTGLTCSAGIASNFMLAKICSDLNKPNGQYVLenDKNAIMEFLKDLPIRKVGGIGRV 322
Cdd:cd03586  115 ----------TEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNKPNGLTVI--PPEDVEEFLAPLPVRKIPGVGKV 182

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 323 CEAQLKAMDIQTVGDMNLKKNLYPLCFTPLSQESFLRTALGLPGRPSESDPRRKSISVERTFSP-TSDFNILLEEHQEIC 401
Cdd:cd03586  183 TAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDRERKSIGVERTFSEdLTDPEELLEELLELA 262

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 193205700 402 RMLEEDVRKSGiVGGKTVTLKLKLSSFDVLTRSLTPSDVVKSLEDIQKFSLELLEKEK-GKEIRLLGVRLSQL 473
Cdd:cd03586  263 EELAERLRKRG-LKGRTVTVKLKYADFSTRTRSRTLPEPTDDAEDIYELALELLEELLdGRPIRLLGVRLSGL 334
PRK02406 PRK02406
DNA polymerase IV; Validated
 90-473 2.84e-92

DNA polymerase IV; Validated


Pssm-ID: 235035 [Multi-domain]  Cd Length: 343  Bit Score: 287.40  E-value: 2.84e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700  90 MDAYFAAVEMRDNPALRTVPMAVGSSA----MLSTSNYLARRFGVRAGMPGFISNKLCPSLTIVPGNYPKYTKVSRQFSQ 165
Cdd:PRK02406   1 MDCFYAAVEMRDNPELRGKPVAVGGSPgrrgVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPGRFDVYKEVSRQIRE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 166 IFMEYDSDVGMMSLDEAFIDLTDyvasntekktfkrhrfggdcpcwlprfdenentledlkieesiCPKCEKS-RKIyyd 244
Cdd:PRK02406  81 IFRRYTDLIEPLSLDEAYLDVTD-------------------------------------------NKLCIGSaTLI--- 114

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 245 hvefgtgreeAvREIRFRVEQLTGLTCSAGIASNFMLAKICSDLNKPNGQYVLENDKnaIMEFLKDLPIRKVGGIGRVCE 324
Cdd:PRK02406 115 ----------A-QEIRQDIFEELGLTASAGVAPNKFLAKIASDWNKPNGLFVITPEE--VDAFLATLPVEKIPGVGKVTA 181

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 325 AQLKAMDIQTVGDmnLKKnlYPLCFtpLSQE------SFLRTALGLPGRPSESDPRRKSISVERTFSptSDFNIL---LE 395
Cdd:PRK02406 182 EKLHALGIYTCAD--LQK--YDLAE--LIRHfgkfgrRLYERARGIDERPVKPDRERKSVGVERTFA--EDLYDLeacLA 253

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 193205700 396 EHQEICRMLEEDVRKSG-IVGGKTVTLKLKLSSFDVLTRSLTPsDVVKSLEDIQKFSLELLEKEKGKEIRLLGVRLSQL 473
Cdd:PRK02406 254 ELPRLAEKLERRLERAKpDKRIKTVGVKLKFADFQQTTKEHTA-DPLDKADLIELLAQALLRRLGGRGVRLLGVGVTLL 331
DinP COG0389
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ...
 86-471 1.21e-90

Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];


Pssm-ID: 440158 [Multi-domain]  Cd Length: 336  Bit Score: 283.19  E-value: 1.21e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700  86 VCIDMDAYFAAVEMRDNPALRTVPMAVGSSAM---LSTSNYLARRFGVRAGMPGFISNKLCPSLTIVPGNYPKYTKVSRQ 162
Cdd:COG0389    4 LHVDMDAFYASVEQRDRPELRGKPVAVGGDNNrgvVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPPDFELYRDVSRR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 163 FSQIFMEYDSDVGMMSLDEAFIDLTDYvasntekktfkRHRFGGdcpcwlprfdenentledlkiEESICpkceksrkiy 242
Cdd:COG0389   84 VMAILERYTPLVEPLSIDEAFLDVTGS-----------ARLFGS---------------------AEAIA---------- 121

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 243 ydhvefgtgreeavREIRFRVEQLTGLTCSAGIASNFMLAKICSDLNKPNGQYVLenDKNAIMEFLKDLPIRKVGGIGRV 322
Cdd:COG0389  122 --------------RRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAKPDGLTVI--PPGEVAAFLAPLPVEKLWGVGPK 185

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 323 CEAQLKAMDIQTVGDmnLKKnlyplcfTPLSQ---------ESFLRTALGLPGRPSESDPRRKSISVERTFS-PTSDFNI 392
Cdd:COG0389  186 TAEKLARLGIRTIGD--LAA-------LPRAElrrrfgkvgERLYRLARGIDPRPVEPRRPRKSIGVERTFGeDLTDLEE 256

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 393 LLEEHQEICRMLEEDVRKSGiVGGKTVTLKLKLSSFDVLTRSLTPSDVVKSLEDIQKFSLELLEK--EKGKEIRLLGVRL 470
Cdd:COG0389  257 LEAALRRLAERLAERLRRQG-LGARTVTVKLRTSDFRTTTRSRTLPEPTDDTAELLRAARELLERiyRPGRPVRLLGVRL 335


                 .
gi 193205700 471 S 471
Cdd:COG0389  336 S 336
IMS pfam00817
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
 88-287 1.54e-43

impB/mucB/samB family; These proteins are involved in UV protection (Swiss).


Pssm-ID: 425885 [Multi-domain]  Cd Length: 148  Bit Score: 152.34  E-value: 1.54e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700   88 IDMDAYFAAVEMRDNPALRTVPMAVGS---SAMLSTSNYLARRFGVRAGMPGFISNKLCPSLTIVPGNYPKYTKVSRQFS 164
Cdd:pfam00817   1 IDMDAFFASVELLRDPELKGKPVAVGGgngRGIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVVPPDLELYRRASRKIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700  165 QIFMEYDSD-VGMMSLDEAFIDLTDYVasntekktfkrHRFGGdcpcwlprfdenentledlkiEESICpkceksrkiyy 243
Cdd:pfam00817  81 EILRRFSTPkVEQASIDEAFLDLTGLE-----------KLFGA---------------------EEALA----------- 117

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 193205700  244 dhvefgtgreeavREIRFRVEQLTGLTCSAGIASNFMLAKICSD 287
Cdd:pfam00817 118 -------------KRLRREIAEETGLTCSIGIAPNKLLAKLASD 148
 
Name Accession Description Interval E-value
PolY_Pol_IV_kappa cd03586
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ...
 86-473 1.89e-128

DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.


Pssm-ID: 176459 [Multi-domain]  Cd Length: 334  Bit Score: 380.33  E-value: 1.89e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700  86 VCIDMDAYFAAVEMRDNPALRTVPMAVGSS---AMLSTSNYLARRFGVRAGMPGFISNKLCPSLTIVPGNYPKYTKVSRQ 162
Cdd:cd03586    1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSsdrGVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYREVSRQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 163 FSQIFMEYDSDVGMMSLDEAFIDLTDYVASNTEKktfkrhrfggdcpcwlprfdenentledlkieesicpkceksrkiy 242
Cdd:cd03586   81 IMEILREYTPLVEPLSIDEAYLDVTDYVRLFGSA---------------------------------------------- 114

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 243 ydhvefgtgrEEAVREIRFRVEQLTGLTCSAGIASNFMLAKICSDLNKPNGQYVLenDKNAIMEFLKDLPIRKVGGIGRV 322
Cdd:cd03586  115 ----------TEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNKPNGLTVI--PPEDVEEFLAPLPVRKIPGVGKV 182

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 323 CEAQLKAMDIQTVGDMNLKKNLYPLCFTPLSQESFLRTALGLPGRPSESDPRRKSISVERTFSP-TSDFNILLEEHQEIC 401
Cdd:cd03586  183 TAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDRERKSIGVERTFSEdLTDPEELLEELLELA 262

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 193205700 402 RMLEEDVRKSGiVGGKTVTLKLKLSSFDVLTRSLTPSDVVKSLEDIQKFSLELLEKEK-GKEIRLLGVRLSQL 473
Cdd:cd03586  263 EELAERLRKRG-LKGRTVTVKLKYADFSTRTRSRTLPEPTDDAEDIYELALELLEELLdGRPIRLLGVRLSGL 334
PRK02406 PRK02406
DNA polymerase IV; Validated
 90-473 2.84e-92

DNA polymerase IV; Validated


Pssm-ID: 235035 [Multi-domain]  Cd Length: 343  Bit Score: 287.40  E-value: 2.84e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700  90 MDAYFAAVEMRDNPALRTVPMAVGSSA----MLSTSNYLARRFGVRAGMPGFISNKLCPSLTIVPGNYPKYTKVSRQFSQ 165
Cdd:PRK02406   1 MDCFYAAVEMRDNPELRGKPVAVGGSPgrrgVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPGRFDVYKEVSRQIRE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 166 IFMEYDSDVGMMSLDEAFIDLTDyvasntekktfkrhrfggdcpcwlprfdenentledlkieesiCPKCEKS-RKIyyd 244
Cdd:PRK02406  81 IFRRYTDLIEPLSLDEAYLDVTD-------------------------------------------NKLCIGSaTLI--- 114

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 245 hvefgtgreeAvREIRFRVEQLTGLTCSAGIASNFMLAKICSDLNKPNGQYVLENDKnaIMEFLKDLPIRKVGGIGRVCE 324
Cdd:PRK02406 115 ----------A-QEIRQDIFEELGLTASAGVAPNKFLAKIASDWNKPNGLFVITPEE--VDAFLATLPVEKIPGVGKVTA 181

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 325 AQLKAMDIQTVGDmnLKKnlYPLCFtpLSQE------SFLRTALGLPGRPSESDPRRKSISVERTFSptSDFNIL---LE 395
Cdd:PRK02406 182 EKLHALGIYTCAD--LQK--YDLAE--LIRHfgkfgrRLYERARGIDERPVKPDRERKSVGVERTFA--EDLYDLeacLA 253

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 193205700 396 EHQEICRMLEEDVRKSG-IVGGKTVTLKLKLSSFDVLTRSLTPsDVVKSLEDIQKFSLELLEKEKGKEIRLLGVRLSQL 473
Cdd:PRK02406 254 ELPRLAEKLERRLERAKpDKRIKTVGVKLKFADFQQTTKEHTA-DPLDKADLIELLAQALLRRLGGRGVRLLGVGVTLL 331
DinP COG0389
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ...
 86-471 1.21e-90

Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];


Pssm-ID: 440158 [Multi-domain]  Cd Length: 336  Bit Score: 283.19  E-value: 1.21e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700  86 VCIDMDAYFAAVEMRDNPALRTVPMAVGSSAM---LSTSNYLARRFGVRAGMPGFISNKLCPSLTIVPGNYPKYTKVSRQ 162
Cdd:COG0389    4 LHVDMDAFYASVEQRDRPELRGKPVAVGGDNNrgvVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPPDFELYRDVSRR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 163 FSQIFMEYDSDVGMMSLDEAFIDLTDYvasntekktfkRHRFGGdcpcwlprfdenentledlkiEESICpkceksrkiy 242
Cdd:COG0389   84 VMAILERYTPLVEPLSIDEAFLDVTGS-----------ARLFGS---------------------AEAIA---------- 121

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 243 ydhvefgtgreeavREIRFRVEQLTGLTCSAGIASNFMLAKICSDLNKPNGQYVLenDKNAIMEFLKDLPIRKVGGIGRV 322
Cdd:COG0389  122 --------------RRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAKPDGLTVI--PPGEVAAFLAPLPVEKLWGVGPK 185

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 323 CEAQLKAMDIQTVGDmnLKKnlyplcfTPLSQ---------ESFLRTALGLPGRPSESDPRRKSISVERTFS-PTSDFNI 392
Cdd:COG0389  186 TAEKLARLGIRTIGD--LAA-------LPRAElrrrfgkvgERLYRLARGIDPRPVEPRRPRKSIGVERTFGeDLTDLEE 256

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 393 LLEEHQEICRMLEEDVRKSGiVGGKTVTLKLKLSSFDVLTRSLTPSDVVKSLEDIQKFSLELLEK--EKGKEIRLLGVRL 470
Cdd:COG0389  257 LEAALRRLAERLAERLRRQG-LGARTVTVKLRTSDFRTTTRSRTLPEPTDDTAELLRAARELLERiyRPGRPVRLLGVRL 335


                 .
gi 193205700 471 S 471
Cdd:COG0389  336 S 336
PTZ00205 PTZ00205
DNA polymerase kappa; Provisional
 2-494 4.41e-64

DNA polymerase kappa; Provisional


Pssm-ID: 140232 [Multi-domain]  Cd Length: 571  Bit Score: 220.66  E-value: 4.41e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700   2 LTFNDNKAGMNGLDKEKITKVIEENTSASYSSFSKKQQSRIEEKVL-EIKNRLQTATR--------EERQKSEILMENLE 72
Cdd:PTZ00205  44 LTLDCNKAGMGNVDKERVEAIIRNVSEGSSFLMNEQRLAEGREKQLqELKRKSSLFTQllggernaAQRKQWELKVSKIE 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700  73 MKLESSRDLSrDCVCIDMDAYFAAVEMRDNPALRTVPMAVGSSAMLSTSNYLARRFGVRAGMPGFISNKLCPSLTIVPGN 152
Cdd:PTZ00205 124 QELEATRRLG-TYIHLDMDMFYAAVEIKKHPEYAAIPLAIGTMTMLQTANYVARGRGIRQGMPGFLALKICPNLLILPPD 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 153 YPKYTKVSRQFSQIFMEYDSDVGMMSLDEAFIDLTDYVasntekktfkrHRFggdcpcwlprfdENENTLEDLkieesic 232
Cdd:PTZ00205 203 FDAYNEESNTVRRIVAEYDPNYISFGLDELTLEVSAYI-----------ERF------------EGTKTAEDV------- 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 233 pkceksrkiyydhvefgtgreeaVREIRFRVEQLTGLTCSAGIASNFMLAKICSDLNKPNGQYVLE-NDKNAIMEFLKDL 311
Cdd:PTZ00205 253 -----------------------ASELRVRVFGETKLTASAGIGPTAALAKIASNINKPNGQHDLNlHTRGDVMTYVRDL 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 312 PIRKVGGIGRVCEAQLKAMDIQTVGDMNLKKnlYPLCFtpLSQESFLRTALG-------------LPGRPSESDP---RR 375
Cdd:PTZ00205 310 GLRSVPGVGKVTEALLKGLGITTLSDIYNRR--VELCY--ILHNNLFRFLLGasigimqwpdaatAANTENCEGAtggQR 385

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 376 KSISVERTFSPTSDFNILLEEHQEICRMLEEDVRKSGIVgGKTVTLKLKLSSF--DVLTRSLTP-SDVVKSLEDIQKfSL 452
Cdd:PTZ00205 386 KAISSERSFTTPRTKEGLQEMVDTVFNGAYEEMRKSELM-CRQISLTIRWASYryQQYTKSLIQySDDSATLRRAVD-GL 463

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*..
gi 193205700 453 ELLEKEKGKEIRLLGVRLSQLIFEEDEKKRSK-----TITEFWNEKK 494
Cdd:PTZ00205 464 LLPHAAKYSEMCLLGVRFLDLISAKDFHMKRKggnqlSISQFIRPKK 510
PRK14133 PRK14133
DNA polymerase IV; Provisional
 88-473 2.21e-61

DNA polymerase IV; Provisional


Pssm-ID: 184529 [Multi-domain]  Cd Length: 347  Bit Score: 206.88  E-value: 2.21e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700  88 IDMDAYFAAVEMRDNPALRTVPMAVGSSA---MLSTSNYLARRFGVRAGMPGFISNKLCPSLTIVPGNYPKYTKVSRQFS 164
Cdd:PRK14133   8 VDMDAFFASVEQMDNPKLKGKPVIVGGISergVVSTCSYEARKYGVHSAMPVFMAKKRCPHGIFLPVRHERYKEVSKNIF 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 165 QIFMEYDSDVGMMSLDEAFIDLTDYvasntekktfkrhrfggdcpcwlprfdeNENTledlkieesicpkceksrkiyyd 244
Cdd:PRK14133  88 KILYEVTPIVEPVSIDEAYLDITNI----------------------------KEEP----------------------- 116

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 245 hvefgtgrEEAVREIRFRVEQLTGLTCSAGIASNFMLAKICSDLNKPNGQYVLENDknAIMEFLKDLPIRKVGGIGRVCE 324
Cdd:PRK14133 117 --------IKIAKYIKKKVKKETGLTLSVGISYNKFLAKLASDWNKPDGIKIITED--MIPDILKPLPISKVHGIGKKSV 186

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 325 AQLKAMDIQTVGDM-NLKKNLYPLCFTPLSQESFLRTAlGLPGRPSESDPRRKSISVERTFSP-TSDFNILLEEHQEICR 402
Cdd:PRK14133 187 EKLNNIGIYTIEDLlKLSREFLIEYFGKFGVEIYERIR-GIDYREVEVSRERKSIGKETTLKKdTKDKEELKKYLKDFSN 265

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 193205700 403 MLEEDVRKSGIvGGKTVTLKLKLSSFDVLTRSLTPSDVVKSLEDIQKFSLELLEKEKGKE-IRLLGVRLSQL 473
Cdd:PRK14133 266 IISEELKKRNL-YGKTVTVKIKTSDFQTHTKSKTLNDYIRDKEEIYNVACEILEHINIKEpIRLIGLSVSNL 336
PRK02794 PRK02794
DNA polymerase IV; Provisional
 88-473 1.98e-55

DNA polymerase IV; Provisional


Pssm-ID: 179473 [Multi-domain]  Cd Length: 419  Bit Score: 193.22  E-value: 1.98e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700  88 IDMDAYFAAVEMRDNPALRTVPMAVG--SSAMLSTSNYLARRFGVRAGMPGFISNKLCPSLTIVPGNYPKYTKVSRQFSQ 165
Cdd:PRK02794  41 IDCDAFYASVEKRDNPELRDKPVIIGggKRGVVSTACYIARIHGVRSAMPMFKALKLCPDAVVIKPDMEKYVRVGREVRA 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 166 IFMEYDSDVGMMSLDEAFIDLtdyvaSNTEkktfkrhRFGGDCPcwlprfdenentledlkieesicpkceksrkiyydh 245
Cdd:PRK02794 121 MMQALTPLVEPLSIDEAFLDL-----SGTE-------RLHGAPP------------------------------------ 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 246 vefgtgreeAVREIRF--RVEQLTGLTCSAGIASNFMLAKICSDLNKPNGQYVLENDKNAimEFLKDLPIRKVGGIGRVC 323
Cdd:PRK02794 153 ---------AVVLARFarRVEREIGITVSVGLSYNKFLAKIASDLDKPRGFSVIGRAEAL--AFLAPKPVGIIWGVGPAT 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 324 EAQLKAMDIQTVGDmnLKKnlyplcftplSQESFL------------RTALGLPGRPSESDPRRKSISVERTF-SPTSDF 390
Cdd:PRK02794 222 AARLARDGIRTIGD--LQR----------ADEADLmrrfgsmglrlwRLARGIDDRKVSPDREAKSVSAETTFeTDLSDF 289

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 391 NILLEEHQEICRMLEEDVRKSGIvGGKTVTLKLKLSSFDVLTRSLTPSDVVKSLEDIQKFSLELLEKE-KGKEIRLLGVR 469
Cdd:PRK02794 290 EDLEPILWRLSEKVSRRLKAAGL-AGRTVTLKLKTADFRLRTRRRTLEDPTQLADRIFRTARELLEKEtDGTAFRLIGIG 368


                 ....
gi 193205700 470 LSQL 473
Cdd:PRK02794 369 VSDL 372
PRK03348 PRK03348
DNA polymerase IV; Provisional
 88-473 3.89e-49

DNA polymerase IV; Provisional


Pssm-ID: 235118 [Multi-domain]  Cd Length: 454  Bit Score: 177.05  E-value: 3.89e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700  88 IDMDAYFAAVEMRDNPALRTVPMAVGSSA---MLSTSNYLARRFGVRAGMPGFISNKLCPSLTIV-PGNYPKYTKVSRQF 163
Cdd:PRK03348  10 LDMDAFFASVEQLTRPTLRGRPVLVGGLGgrgVVAGASYEARVFGARSAMPMHQARRLVGNGAVVlPPRFVVYRAASRRV 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 164 SQIFMEYDSDVGMMSLDEAFIDLTDYVASNTEkktfkrhrfggdcpcwlprfdenentledlkieesicpkceksrkiyy 243
Cdd:PRK03348  90 FDTLRELSPVVEQLSFDEAFVEPAELAGASAE------------------------------------------------ 121

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 244 dhvefgtGREEAVREIRFRVEQLTGLTCSAGIASNFMLAKICSDLNKPNGQYVLENDKNaiMEFLKDLPIRKVGGIGRVC 323
Cdd:PRK03348 122 -------EVEAFAERLRARVREETGLPASVGAGSGKQIAKIASGLAKPDGIRVVPPGEE--RELLAPLPVRRLWGIGPVT 192

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 324 EAQLKAMDIQTVGDmnlkknlyplcFTPLSQE------------SFLRTALGLPGRPSESDPRRKSISVERTFSptSDFN 391
Cdd:PRK03348 193 EEKLHRLGIETIGD-----------LAALSEAevanllgatvgpALHRLARGIDDRPVAERAEAKQISAESTFA--VDLT 259

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 392 ILLEEHQEICRMLEEDVR---KSGIvGGKTVTLKLKLSSFDVLTRSLT---PSDVVKSLEDI-QKFSLELLEKEKgkeIR 464
Cdd:PRK03348 260 TRAQLREAIERIAEHAHRrllKDGR-GARTVTVKLRKSDFSTLTRSATlpyATDDAAVLAATaRRLLLDPDEIGP---IR 335


                 ....*....
gi 193205700 465 LLGVRLSQL 473
Cdd:PRK03348 336 LVGVGFSGL 344
IMS pfam00817
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
 88-287 1.54e-43

impB/mucB/samB family; These proteins are involved in UV protection (Swiss).


Pssm-ID: 425885 [Multi-domain]  Cd Length: 148  Bit Score: 152.34  E-value: 1.54e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700   88 IDMDAYFAAVEMRDNPALRTVPMAVGS---SAMLSTSNYLARRFGVRAGMPGFISNKLCPSLTIVPGNYPKYTKVSRQFS 164
Cdd:pfam00817   1 IDMDAFFASVELLRDPELKGKPVAVGGgngRGIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVVPPDLELYRRASRKIF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700  165 QIFMEYDSD-VGMMSLDEAFIDLTDYVasntekktfkrHRFGGdcpcwlprfdenentledlkiEESICpkceksrkiyy 243
Cdd:pfam00817  81 EILRRFSTPkVEQASIDEAFLDLTGLE-----------KLFGA---------------------EEALA----------- 117

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 193205700  244 dhvefgtgreeavREIRFRVEQLTGLTCSAGIASNFMLAKICSD 287
Cdd:pfam00817 118 -------------KRLRREIAEETGLTCSIGIAPNKLLAKLASD 148
PRK01810 PRK01810
DNA polymerase IV; Validated
 88-493 9.66e-43

DNA polymerase IV; Validated


Pssm-ID: 179337 [Multi-domain]  Cd Length: 407  Bit Score: 158.27  E-value: 9.66e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700  88 IDMDAYFAAVEMRDNPALRTVPMAVGSSA-----MLSTSNYLARRFGVRAGMPGFISNKLCPSLTIVPGNYPKYTKVSRQ 162
Cdd:PRK01810  10 VDMNSFFASVEIAYDPSLQGKPLAVAGNEkerkgIIVTCSYEARAYGIRTTMPLWEAKRLCPQLIVRRPNFDRYREASRQ 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 163 FSQIFMEYDSDVGMMSLDEAFIDLTDYVASNTekktfkrhrfggdcPCwlprfdenentledlkieesicpkceksrkiy 242
Cdd:PRK01810  90 MFQILSEFTPLVQPVSIDEGYLDITDCYALGS--------------PL-------------------------------- 123

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 243 ydhvefgtgreEAVREIRFRVEQLTGLTCSAGIASNFMLAKICSDLNKPNGQYVLEndKNAIMEFLKDLPIRKVGGIGRV 322
Cdd:PRK01810 124 -----------EIAKMIQQRLLTELQLPCSIGIAPNKFLAKMASDMKKPLGITVLR--KRDVPEMLWPLPVGEMHGIGEK 190

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 323 CEAQLKAMDIQTVGDmnLKKnlyplcftplSQESFLRTALGLPGR----------PSESDPRR----KSISVERTFS-PT 387
Cdd:PRK01810 191 TAEKLKDIGIQTIGD--LAK----------ADEHILRAKLGINGVrlqrrangidDRPVDPEAiyqfKSVGNSTTLShDM 258

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 388 SDFNILLEEHQEICRMLEEDVRKSGIVgGKTVTLKLKLSSFDVLTRSLTPSDVVKSLEDIQKFSLELLEKE-KGKEIRLL 466
Cdd:PRK01810 259 DEEKELLDVLRRLSKSVSKRLQKKTVV-SYNVQIMIRYHDRRTITRSKTLKNPIWEKRDIFQAASRLFKQHwNGDPVRLL 337

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 193205700 467 GVRLSQLI-------------FEEDEKKR--SKTITEFwNEK 493
Cdd:PRK01810 338 GVTATDLEwkteavkqldlfsFEEDAKEEplLAVIDQI-NDK 378
PolY_Rev1 cd01701
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ...
 50-473 5.66e-41

DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.


Pssm-ID: 176455 [Multi-domain]  Cd Length: 404  Bit Score: 153.24  E-value: 5.66e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700  50 KNRLqtatREERQKSEILMENLEMKLESSRDLSRDCVCIDMDAYFAAVEMRDNPALRTVPMAVGSS----AMLSTSNYLA 125
Cdd:cd01701   18 KARL----KDFFRELSNGSKEADPSNSIHPDLQRIIMHVDFDCFFVSVSIRNRPDLKGKPVAVCHGkgpnSEIASCNYEA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 126 RRFGVRAGMpgFISN--KLCPSLTIVPGNYPKYTKVSRQFSQIFMEYDSDVGMMSLDEAFIDLTDyvasntekktfkrhr 203
Cdd:cd01701   94 RSYGIKNGM--WVGQakKLCPQLVTLPYDFEAYEEVSLTFYEILASYTDNIEAVSCDEALIDITS--------------- 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 204 fggdcpcwlprFDENENTLEDlkieesicPKCEksrkiyydhvefgtgreeavrEIRFRVEQLTGLTCSAGIASNFMLAK 283
Cdd:cd01701  157 -----------LLEETYELPE--------ELAE---------------------AIRNEIRETTGCSASVGIGPNILLAR 196

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 284 ICSDLNKPNGQYVLenDKNAIMEFLKDLPIRKVGGIGRVCEAQLKAMDIQTVGDMNL----KKNLYPLcFTPLSQESFLR 359
Cdd:cd01701  197 LATRKAKPDGQYHL--SAEKVEEFLSQLKVGDLPGVGSSLAEKLVKLFGDTCGGLELrsktKEKLQKV-LGPKTGEKLYD 273

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 360 TALGLPGRPSESDPRRKSISVE-----RTFSPTSDFNILLEEHQEICRMLEEDVRKsgivgGKTVTLKLKL--------- 425
Cdd:cd01701  274 YCRGIDDRPVTGEKERKSVSAEinygiRFTNVDDVEQFLQRLSEELSKRLEESNVT-----GRQITLKLMKrapgapiep 348

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 193205700 426 SSF------DVLTRSLTPSDVVKSLEDIQKFSLELLE--KEKGKEIRLLGVRLSQL 473
Cdd:cd01701  349 PKYmghgicDSFSKSSTLGVATDDSGVIGTEAKKLFRdlSIPPEELRGVGIQVTKL 404
PRK03858 PRK03858
DNA polymerase IV; Validated
 89-473 6.70e-40

DNA polymerase IV; Validated


Pssm-ID: 179663 [Multi-domain]  Cd Length: 396  Bit Score: 150.14  E-value: 6.70e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700  89 DMDAYFAAVEMRDNPALRTVPMAVGSSAMLSTSnYLARRFGVRAGMPGFISNKLCPSLTIVPGNYPKYTKVSRQFSQIFM 168
Cdd:PRK03858  10 DLDSFYASVEQRDDPALRGRPVIVGGGVVLAAS-YEAKAYGVRTAMGGRQARRLCPQAVVVPPRMSAYSRASKAVFEVFR 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 169 EYDSDVGMMSLDEAFIDLtdyvasntekktfkrhrfGGdcpcwlprfdenentledlkieesicpkcekSRKIyydhveF 248
Cdd:PRK03858  89 DTTPLVEGLSIDEAFLDV------------------GG-------------------------------LRRI------S 113

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 249 GTGREEAVReIRFRVEQLTGLTCSAGIASNFMLAKICSDLNKPNGQYVLENDKNaiMEFLKDLPIRKVGGIGRVCEAQLK 328
Cdd:PRK03858 114 GTPVQIAAR-LRRRVREEVGLPITVGVARTKFLAKVASQVAKPDGLLVVPPDRE--LAFLHPLPVRRLWGVGPVTAAKLR 190

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 329 AMDIQTVGDMnlkknlyplcftPLSQESFLRTALGlPG--------------RPSESDPRRKSISVERTF--SPTSDfni 392
Cdd:PRK03858 191 AHGITTVGDV------------AELPESALVSLLG-PAagrhlhalahnrdpRRVETGRRRRSVGAQRALgrGPNSP--- 254

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 393 llEEHQEICRMLEEDV----RKSGIVgGKTVTLKLKLSSFDVLTRSLTPSDVVKSLEDIQKFSLELLE------KEKGke 462
Cdd:PRK03858 255 --AEVDAVVVALVDRVarrmRAAGRT-GRTVVLRLRFDDFTRATRSHTLPRPTASTATLLAAARDLVAaaapliAERG-- 329

                        410
                 ....*....|.
gi 193205700 463 IRLLGVRLSQL 473
Cdd:PRK03858 330 LTLVGFAVSNL 340
PRK03103 PRK03103
DNA polymerase IV; Reviewed
 88-483 2.10e-37

DNA polymerase IV; Reviewed


Pssm-ID: 235104 [Multi-domain]  Cd Length: 409  Bit Score: 143.60  E-value: 2.10e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700  88 IDMDAYFAAVEMRDNPALRTVPMAVG------SSAMLSTSnYLARRFGVRAGMPGFISNKLCPSLTIVPGNYPKYTKVSR 161
Cdd:PRK03103   8 VDMQSFYASVEKAANPELKGRPVIVSgdperrSGVVLAAC-PLAKAYGVKTAERLWEAQQKCPDLVVVKPRMQRYIDVSL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 162 QFSQIFMEYDSDVGMMSLDEAFIDLTdyvasntekktfkrhrfggdcpcwlprfdenentledlkieesicpkceKSRKI 241
Cdd:PRK03103  87 QITRILEDFTDLVEPFSIDEQFLDVT-------------------------------------------------GSQKL 117

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 242 yydhveFGTGREEAVReIRFRVEQLTGLTCSAGIASNFMLAKICSDL---NKPNGQYVLenDKNAIMEFLKDLPIRKVGG 318
Cdd:PRK03103 118 ------FGSPLEIAQK-IQQRIMRETGVYARVGIGPNKLLAKMACDNfakKNPDGLFTL--DKEDVPADLWPLPVRKLFG 188

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 319 IGRVCEAQLKAMDIQTVGDmnlkknlypLCFTPLSQ---------ESFLRTALGL---PGRPSESDpRRKSISVERT--- 383
Cdd:PRK03103 189 VGSRMEKHLRRMGIRTIGQ---------LANTPLERlkkrwgingEVLWRTANGIdysPVTPHSLD-RQKAIGHQMTlpr 258

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 384 -FSPTSDFN-ILLEEHQEICRMleedVRKSGIVgGKTVTLKLKLSSFDVLT---RSLTPSDVVKSLEDIQKFSLELLEKE 458
Cdd:PRK03103 259 dYRGFEEIKvVLLELCEEVCRR----ARAKGYM-GRTVSVSLRGADFDWPTgfsRQMTLPEPTNLAMEVYEAACKLFHRH 333

                        410       420       430
                 ....*....|....*....|....*....|....*
gi 193205700 459 -KGKEIRLLGVRLSQL---------IFEEDEKKRS 483
Cdd:PRK03103 334 wDGKPVRRVGVTLSNLvsddvwqlsLFGDRERKRS 368
PolY cd00424
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ...
 88-471 1.70e-35

Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.


Pssm-ID: 176453 [Multi-domain]  Cd Length: 343  Bit Score: 136.34  E-value: 1.70e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700  88 IDMDAYFAAVEMRDNPALRTVPMAV----GSSAMLSTSNYLARRFGVRAGMPGFISNKLCPSLTIVPGNYPKYTKVSRQF 163
Cdd:cd00424    3 IDFDNFFASVEQLARPELKGRPVVVvpfnSDSTCVIACSYEARKYGVKRGMPVREARKMCPNLILVPARLDLYRRLSERL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 164 SQIFMEYDSDVGMMSLDEAFIDLTDYVASNTEkktfkrhrfGGDcpcwlprfdenentledlkieesicpKCEKSRkiyy 243
Cdd:cd00424   83 LSELEEVAPLVEVASIDELFLDLTGSARLLGL---------GSE--------------------------VALRIK---- 123

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 244 dhvefgtgreeavREIRfrvEQLTGLTCSAGIASNFMLAKICSDLNKPNGQYVLENDknAIMEFLKDLPIRKVGGIGRVC 323
Cdd:cd00424  124 -------------RHIA---EQLGGITASIGIASNKLLAKLAAKYAKPDGLTILDPE--DLPGFLSKLPLTDLPGIGAVT 185

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 324 EAQLKAMDIQTVGDM-NLK-KNLYPLCFTPLSQESFLRtALGLPGRPSESDPRRKSISVERTFSPTSDfNILLEEH--QE 399
Cdd:cd00424  186 AKRLEAVGINPIGDLlAASpDALLALWGGVSGERLWYA-LRGIDDEPLSPPRPRKSFSHERVLPRDSR-NAEDARPllRL 263

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 400 ICRMLEEDVRKSGiVGGKTVTLKLKL------SSFDVLTRSLTPSDVVKSLE---DIQKFSLELLEKEKGKEIRLLGVRL 470
Cdd:cd00424  264 LLEKLARRLRRDG-RGATRLRLWLRTvdgrwsGHADIPSRSAPRPISTEDGEllhALDKLWRALLDDKGPRRLRRLGVRL 342


                 .
gi 193205700 471 S 471
Cdd:cd00424  343 S 343
PRK03352 PRK03352
DNA polymerase IV; Validated
 88-470 8.08e-30

DNA polymerase IV; Validated


Pssm-ID: 179564 [Multi-domain]  Cd Length: 346  Bit Score: 120.51  E-value: 8.08e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700  88 IDMDAYFAAVEMRDNPALRTVPMAVGSS-------AMLSTSNYLARRFGVRAGMPGFISNKLCPSLTIVPGNYPKYTKVS 160
Cdd:PRK03352  10 VDLDQFIAAVELLRRPELAGLPVIVGGNgdpteprKVVTCASYEARAFGVRAGMPLRTAARRCPDAVFLPSDPAAYDAAS 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 161 RQFSQIFMEYDSDVGMMSLDEAFIDLtdyvasntekktfkrhrfggdcpcwlprfdenentledlkieesicpkceksrk 240
Cdd:PRK03352  90 EEVMATLRDLGVPVEVWGWDEAFLGV------------------------------------------------------ 115

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 241 iyydhvefGTGREEAV-REIRFRVEQLTGLTCSAGIASNFMLAKICSDLNKPNGQYVLeNDKNAiMEFLKDLPIRKVGGI 319
Cdd:PRK03352 116 --------DTDDPEALaEEIRAAVLERTGLSCSVGIGDNKLRAKIATGFAKPAGVFRL-TDANW-MAVMGDRPTDALWGV 185

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 320 GRVCEAQLKAMDIQTVGDM------NLKKNlyplcFTPLSQESFLRTALGLPGRPSESDPR-RKSISVERTFSPT-SDFN 391
Cdd:PRK03352 186 GPKTAKRLAALGITTVADLaaadpaELAAT-----FGPTTGPWLLLLARGGGDTEVSAEPWvPRSRSREVTFPQDlTDRA 260

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 392 ILLEEHQEICRMLEEDVRKSG-IVGGktVTLKLKLSSFDVLTRSLTPSDVVKSLEDIQKFSLELLEK-EKGKEIRLLGVR 469
Cdd:PRK03352 261 EVESAVRELARRVLDEVVAEGrPVTR--VAVKVRTATFYTRTKIRKLPEPTTDPDVIEAAALDVLDRfELDRPVRLLGVR 338


                 .
gi 193205700 470 L 470
Cdd:PRK03352 339 L 339
PolY_Pol_iota cd01703
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ...
 89-468 1.08e-29

DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.


Pssm-ID: 176457 [Multi-domain]  Cd Length: 379  Bit Score: 120.65  E-value: 1.08e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700  89 DMDAYFAAVEMRDNPALRTVPMAVGSSAMLSTSNYLARRFGVRAGMPGFISNKLCPSLTIVPG-NYPKYTKVSRQFSQIF 167
Cdd:cd01703    4 DLDCFYAQVEEIRDPSLKSKPLGIQQKYIVVTCNYEARRLGVKKLMSIKDAKEICPDLVLVNGeDLTPFRDMSKKVYRLL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 168 MEY--DSDVGMMSLDEAFIDLTDY---VASntekktfkrhRFGGdcpcwlprfdenentledlkieesicpkceksrkiy 242
Cdd:cd01703   84 RSYswNDRVERLGFDENFMDVTEMrllVAS----------HIAY------------------------------------ 117

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 243 ydhvefgtgreeavrEIRFRVEQLTGLTCSAGIASNFMLAKICSDLNKPNGQYVLENDKNA-IMEFLKDLPIRKVGGIGR 321
Cdd:cd01703  118 ---------------EMRERIENELGLTCCAGIASNKLLAKLVGSVNKPNQQTTLLPPSCAdLMDFMDLHDLRKIPGIGY 182

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 322 VCEAQLKAMDIQTVGDMNLKKN-------LYPLCFTPLSQESFLRTALG------LPGR-PSESDPRR---KSISVERTF 384
Cdd:cd01703  183 KTAAKLEAHGISSVRDLQEFSNrnrqtvgAAPSLLELLLMVKEFGEGIGqriwklLFGRdTSPVKPASdfpQQISIEDSY 262

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 385 SPTSDFNILLEEHQ--EICRMLEEDVRK-----SGIVGGKTVTLKLKLSSFDVLTRSLT--------PSDVVKSL----E 445
Cdd:cd01703  263 KKCSLEEIREARNKieELLASLLERMKQdlqevKAGDGRRPHTLRLTLRRYTSTKKHYNreskqapiPSHVFQKLtggnE 342

                        410       420       430
                 ....*....|....*....|....*....|...
gi 193205700 446 DIQKFSLELLEK----------EKGKEIRLLGV 468
Cdd:cd01703  343 IAARPIEKILMRlfrelvppknVKGFNLTLLNV 375
PolY_Pol_V_umuC cd01700
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ...
 87-472 3.85e-29

umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.


Pssm-ID: 176454 [Multi-domain]  Cd Length: 344  Bit Score: 118.42  E-value: 3.85e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700  87 CIDMDAYFAAVEMRDNPALRTVPMAVgssamLSTS-------NYLARRFGVRAGMPGFISNKLCPSL--TIVPGNYPKYT 157
Cdd:cd01700    2 LVDCNSFYASCERVFRPLLLGRPLVV-----LSNNdgcviarSPEAKALGIKMGSPYFKVPDLLERHgvAVFSSNYALYG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 158 KVSRQFSQIFMEYDSDVGMMSLDEAFIDLTDYvasntekktfkrhrfggdcpcwlPRFDenentledlkieesicpkcek 237
Cdd:cd01700   77 DMSRRIMSILERFSPDVEVYSIDESFLDLTGS-----------------------LRFG--------------------- 112

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 238 srkiyyDHVEFGtgreeavREIRFRVEQLTGLTCSAGIASNFMLAKICSDL----NKPNGQYVLENDKNAiMEFLKDLPI 313
Cdd:cd01700  113 ------DLEELA-------RKIRRRILQETGIPVTVGIGPTKTLAKLANDLakkkNPYGGVVDLTDEEVR-DKLLKILPV 178

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 314 RKVGGIGRVCEAQLKAMDIQTVGD---MN---LKKNlyplcFTPLSqesfLRTALGLPG----RPSESDPRRKSISVERT 383
Cdd:cd01700  179 GDVWGIGRRTAKKLNAMGIHTAGDlaqADpdlLRKK-----FGVVG----ERLVRELNGidclPLEEYPPPKKSIGSSRS 249

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 384 F-SPTSDFNILLEEHQEICRMLEEDVRKSGIVgGKTVTLKLKLSSFDV-LTRSLTPSDVVKSLEDIQ---KFSLELLEK- 457
Cdd:cd01700  250 FgRDVTDLDELKQALAEYAERAAEKLRRQKSV-ARTISVFIGTSGFSRqPKYYSATNTLPYPTNDTReivKAALRLLYAi 328

                        410
                 ....*....|....*.
gi 193205700 458 -EKGKEIRLLGVRLSQ 472
Cdd:cd01700  329 yRPGYAYRKAGVMLSD 344
PRK01216 PRK01216
DNA polymerase IV; Validated
 88-491 4.67e-29

DNA polymerase IV; Validated


Pssm-ID: 179251 [Multi-domain]  Cd Length: 351  Bit Score: 118.35  E-value: 4.67e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700  88 IDMDAYFAAVEMRDNPALRTVPMAVG-------SSAMLSTSNYLARRFGVRAGMPGFISNKLCPSLTIVPGNYPKYTKVS 160
Cdd:PRK01216   6 VDFDYFFAQVEEVLNPSLKGKPVVVCvysgrfeDSGAVATANYEARKLGIKAGMPIVEAKKILPNAVYLPMRKEVYQQVS 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 161 RQFSQIFMEYDSDVGMMSLDEAFIDLTDYVASNTEKKtfkrhrfggdcpcwlprfdenentledlkieesicpkceksrk 240
Cdd:PRK01216  86 NRIMKLLREYSEKIEIASIDEAYLDISDKVKNYQDAY------------------------------------------- 122

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 241 iyydhvefgtgreEAVREIRFRVEQLTGLTCSAGIASNFMLAKICSDLNKPNGQYVLENDKnaIMEFLKDLPIRKVGGIG 320
Cdd:PRK01216 123 -------------NLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNGIKVIDDEE--VKRFINELDIADIPGIG 187

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 321 RVCEAQLKAMDIQTVGDMnLKKNLYPL-CFTPLSQESFL----RTALGLPGRPSESDPRRKSISVERTfspTSDFNILLE 395
Cdd:PRK01216 188 DITAEKLKKLGVNKLVDT-LRIEFDELkGIIGEAKAKYLfslaRNEYNEPVRARVRKSIGRYVTLPRN---TRDLEEIKP 263

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 396 ehqEICRMLEEDVRK-SGIvgGKTVTLKLKLSSFDVLTRSLTPSDVVkSLEDIQKFSLELLEK---EKGKEIRLLGVRLS 471
Cdd:PRK01216 264 ---YLKRAIEEAYYKlDGI--PKAIHVVAIMEDLDIVSRGRTFTHGI-SKETAYREAVRLLQKileEDERKIRRIGVRFS 337

                        410       420
                 ....*....|....*....|
gi 193205700 472 QLIfeedekkRSKTITEFWN 491
Cdd:PRK01216 338 KII-------EAIGLDKFFD 350
PolY_Pol_eta cd01702
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ...
 88-437 2.87e-25

DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.


Pssm-ID: 176456 [Multi-domain]  Cd Length: 359  Bit Score: 107.40  E-value: 2.87e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700  88 IDMDAYFAAVEMRDNPALRTVPMAVGSSAMLSTSNYLARRFGVRAGMPGFISNKLCPslTIVPGNYPKYTKvsrqfsqif 167
Cdd:cd01702    3 IDMDAFFAQVEQVRLGLLRNDPVAVVQWNSIIAVSYAARAFGVTRFMTIDEAKKKCP--DLILAHVATYKK--------- 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 168 meydsdvgmmslDEAFIDLTDYVASNTEKKTFKRHRfggdcpcwlprfdenENTLEDLKIEESICPKCEKSrKIYYDHVE 247
Cdd:cd01702   72 ------------GEDEADYHENPSPARHKVSLDPYR---------------RASRKILNILKRFGDVVEKA-SIDEAYLD 123

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 248 FGTgreEAVREIRFRVEQLTGLTCSAGIASNFMLAKICSDLNKPNGQYVLENDknAIMEFLKDLPIRKVGG--------- 318
Cdd:cd01702  124 LGS---RIVEEIRQQVYDELGYTCSAGIAHNKMLAKLASGMNKPNAQTILRND--AVASFLSSLPITSIRGlggklgeei 198

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 319 --------IGRVCEAQLKAMDIQTVGDMNLKKNLYPLCftplsqesflRtalGLPGRPSESDPRRKSISVERTFSPTSDF 390
Cdd:cd01702  199 idllglptEGDVAGFRSSESDLQEHFGEKLGEWLYNLL----------R---GIDHEPVKPRPLPKSMGSSKNFPGKTAL 265

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 193205700 391 NI------LLEEHQEICRMLEEDvRKSGIVGGKTVTLKLKLSSFDVLTRSLTP 437
Cdd:cd01702  266 STedvqhwLLVLASELNSRLEDD-RYENNRRPKTLVLSLRQRGDGVRRSRSCA 317
IMS_C pfam11799
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
 375-477 1.66e-16

impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).


Pssm-ID: 463354 [Multi-domain]  Cd Length: 104  Bit Score: 75.29  E-value: 1.66e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700  375 RKSISVERTFS-PTSDFNILLEEHQEICRMLEEDVRKSGIVGgKTVTLKLKLSSFDVLTRSLTPSDVVKSLEDIQKFSLE 453
Cdd:pfam11799   1 RKSIGAERTFGrDLTDLEELREALLELAEELAERLRRQGLVA-RTVTVKIRYSDFRTITRSVTLPSPTDDTDEIYRAALR 79

                          90       100
                  ....*....|....*....|....*
gi 193205700  454 LLEK-EKGKEIRLLGVRLSQLIFEE 477
Cdd:pfam11799  80 LLRRlYRGRPVRLLGVSLSNLVPEG 104
IMS_HHH pfam11798
IMS family HHH motif; These proteins are involved in UV protection, eg.
 301-332 1.51e-05

IMS family HHH motif; These proteins are involved in UV protection, eg.


Pssm-ID: 432081 [Multi-domain]  Cd Length: 32  Bit Score: 42.00  E-value: 1.51e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 193205700  301 KNAIMEFLKDLPIRKVGGIGRVCEAQLKAMDI 332
Cdd:pfam11798   1 PDDVPEFLWPLPISKIPGIGKKLAEKLKALGI 32
umuC PRK03609
translesion error-prone DNA polymerase V subunit UmuC;
89-338 4.54e-05

translesion error-prone DNA polymerase V subunit UmuC;


Pssm-ID: 179607 [Multi-domain]  Cd Length: 422  Bit Score: 46.30  E-value: 4.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700  89 DMDAYFAAVEMRDNPALRTVPMAVGSS--AMLSTSNYLARRFGVRAGMPGF-ISNKLCPSLTIV-PGNYPKYTKVSRQFS 164
Cdd:PRK03609   6 DVNSFYASCETVFRPDLRGKPVVVLSNndGCVIARSAEAKALGIKMGDPWFkQKDLFRRCGVVCfSSNYELYADMSNRVM 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 165 QIFMEYDSDVGMMSLDEAFIDLTDYvasntekktfkrhrfggdcpcwlprfdENENTLEDlkieesicpkceksrkiyyd 244
Cdd:PRK03609  86 STLEELSPRVEIYSIDEAFCDLTGV---------------------------RNCRDLTD-------------------- 118

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205700 245 hveFGtgreeavREIRFRVEQLTGLTCSAGIASNFMLAKICSDLNKP----NGQYVLENDKNAIMEFLKDLPIRKVGGIG 320
Cdd:PRK03609 119 ---FG-------REIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKwqrqTGGVVDLSNLERQRKLLSLQPVEEVWGVG 188

                        250
                 ....*....|....*...
gi 193205700 321 RVCEAQLKAMDIQTVGDM 338
Cdd:PRK03609 189 RRISKKLNAMGIKTALDL 206
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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