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Conserved domains on  [gi|193205371|ref|NP_001122672|]
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RGS domain-containing protein [Caenorhabditis elegans]

Protein Classification

regulator of G-protein signaling domain-containing protein; G protein-coupled receptor kinase( domain architecture ID 10685826)

regulator of G-protein signaling (RGS) domain-containing protein belongs to a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs); similar to Caenorhabditis elegans regulator of G-protein signaling rgs-5/10| G protein-coupled receptor kinase is a serine/threonine-protein kinase that phosphorylate and regulate G protein-coupled receptors (GPCRs)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 181-303 6.86e-21

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


:

Pssm-ID: 214613  Cd Length: 118  Bit Score: 87.71  E-value: 6.86e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205371   181 SLADILKVQPLLLSFLEFIKEKEDHDTIQFLLGCDSFEanlDLMEDSEALGDAMALYEKYFSMQATNMIDLGSAIRAEME 260
Cdd:smart00315   1 SLESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFK---KAEDDEERIAKAREIYDKFLSPNAPKEVNLDSDLREKIE 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 193205371   261 SLICEEsgRPNRKAFRTAKTACFFRLHDKYLSDFLKTSYYHNY 303
Cdd:smart00315  78 ENLESE--EPPPDLFDEAQREVYELLEKDSFPRFLESDYYLRF 118
RGS super family cl45998
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 81-170 2.67e-13

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


The actual alignment was detected with superfamily member pfam00615:

Pssm-ID: 459870  Cd Length: 117  Bit Score: 66.10  E-value: 2.67e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205371   81 SLDRLLIDSSALSYFIQYLDSTDKLNLIKFWMHVEGFKSSF--SEQIQAAQE------YKLSASPLQ------------- 139
Cdd:pfam00615   1 SFDSLLEDQPGRRLFRQFLESEFSEENLEFWLACEEFKKADpdEERLKKAKEiyneflAPGSPKEINldsdlreeirenl 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 193205371  140 -----KSCFDEAQDFVKSLFEYRYFDEFQNSVYYKK 170
Cdd:pfam00615  81 ekeptRDLFDEAQAEVYELMEKDSYPRFLKSPLYLR 116
 
Name Accession Description Interval E-value
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 181-303 6.86e-21

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 87.71  E-value: 6.86e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205371   181 SLADILKVQPLLLSFLEFIKEKEDHDTIQFLLGCDSFEanlDLMEDSEALGDAMALYEKYFSMQATNMIDLGSAIRAEME 260
Cdd:smart00315   1 SLESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFK---KAEDDEERIAKAREIYDKFLSPNAPKEVNLDSDLREKIE 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 193205371   261 SLICEEsgRPNRKAFRTAKTACFFRLHDKYLSDFLKTSYYHNY 303
Cdd:smart00315  78 ENLESE--EPPPDLFDEAQREVYELLEKDSFPRFLESDYYLRF 118
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 181-303 1.71e-20

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 86.51  E-value: 1.71e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205371  181 SLADILKVQPLLLSFLEFIKEKEDHDTIQFLLGCDSFEAnldLMEDSEALGDAMALYEKYFSMQATNMIDLGSAIRAEME 260
Cdd:pfam00615   1 SFDSLLEDQPGRRLFRQFLESEFSEENLEFWLACEEFKK---ADPDEERLKKAKEIYNEFLAPGSPKEINLDSDLREEIR 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 193205371  261 SLICEEsgrPNRKAFRTAKTACFFRLHDKYLSDFLKTSYYHNY 303
Cdd:pfam00615  78 ENLEKE---PTRDLFDEAQAEVYELMEKDSYPRFLKSPLYLRL 117
RGS_AKAP2_2 cd08721
Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, ...
 185-302 3.10e-19

Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the second RGS domain.


Pssm-ID: 188676  Cd Length: 121  Bit Score: 83.16  E-value: 3.10e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205371 185 ILKVQPLLLSFLEFIKEKEDHDTIQFLLGCDSFEANLDLMEDS----EALGDAMALYEKYFSMQATNMIDLGSAIRAEME 260
Cdd:cd08721    1 ILYCESALFYFMEYMEQEGARNLLQFWLAADNFQSQLAAKEGQydgqQAQNDAMIIYDKYFSLQATEPLGFDDKTRLEVE 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 193205371 261 SLICEEsGRPNRKAFRTAKTACFFRLHDKYLSDFLKTSYYHN 302
Cdd:cd08721   81 SNICRE-GGPLPSCFEAPLLQALTTLEQHYLPGFLSSQLYYK 121
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 81-170 2.67e-13

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 66.10  E-value: 2.67e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205371   81 SLDRLLIDSSALSYFIQYLDSTDKLNLIKFWMHVEGFKSSF--SEQIQAAQE------YKLSASPLQ------------- 139
Cdd:pfam00615   1 SFDSLLEDQPGRRLFRQFLESEFSEENLEFWLACEEFKKADpdEERLKKAKEiyneflAPGSPKEINldsdlreeirenl 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 193205371  140 -----KSCFDEAQDFVKSLFEYRYFDEFQNSVYYKK 170
Cdd:pfam00615  81 ekeptRDLFDEAQAEVYELMEKDSYPRFLKSPLYLR 116
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 81-171 1.11e-09

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 55.74  E-value: 1.11e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205371    81 SLDRLLIDSSALSYFIQYLDSTDKLNLIKFWMHVEGFKSSF--SEQIQAAQE-------------------------YKL 133
Cdd:smart00315   1 SLESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFKKAEddEERIAKAREiydkflspnapkevnldsdlrekieENL 80

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 193205371   134 SASPLQKSCFDEAQDFVKSLFEYRYFDEFQNSVYYKKH 171
Cdd:smart00315  81 ESEEPPPDLFDEAQREVYELLEKDSFPRFLESDYYLRF 118
RGS cd07440
Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ...
 86-170 6.89e-09

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.


Pssm-ID: 188659 [Multi-domain]  Cd Length: 113  Bit Score: 53.55  E-value: 6.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205371  86 LIDSSALSYFIQYLDSTDKLNLIKFWMHVEGFKSS----------------------------FSEQIQAAQEYKLSASP 137
Cdd:cd07440    1 LRDPYGLEYFRQFLKSEHCEENLEFWLAVEKFKKTtssdeelkskakeiydkyiskdapkeinIPESIREEIEENLEEPY 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 193205371 138 LQKSCFDEAQDFVKSLFEYRYFDEFQNSVYYKK 170
Cdd:cd07440   81 PDPDCFDEAQEHILNLLEKDSYPRFLKSDLYLK 113
 
Name Accession Description Interval E-value
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 181-303 6.86e-21

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 87.71  E-value: 6.86e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205371   181 SLADILKVQPLLLSFLEFIKEKEDHDTIQFLLGCDSFEanlDLMEDSEALGDAMALYEKYFSMQATNMIDLGSAIRAEME 260
Cdd:smart00315   1 SLESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFK---KAEDDEERIAKAREIYDKFLSPNAPKEVNLDSDLREKIE 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 193205371   261 SLICEEsgRPNRKAFRTAKTACFFRLHDKYLSDFLKTSYYHNY 303
Cdd:smart00315  78 ENLESE--EPPPDLFDEAQREVYELLEKDSFPRFLESDYYLRF 118
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 181-303 1.71e-20

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 86.51  E-value: 1.71e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205371  181 SLADILKVQPLLLSFLEFIKEKEDHDTIQFLLGCDSFEAnldLMEDSEALGDAMALYEKYFSMQATNMIDLGSAIRAEME 260
Cdd:pfam00615   1 SFDSLLEDQPGRRLFRQFLESEFSEENLEFWLACEEFKK---ADPDEERLKKAKEIYNEFLAPGSPKEINLDSDLREEIR 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 193205371  261 SLICEEsgrPNRKAFRTAKTACFFRLHDKYLSDFLKTSYYHNY 303
Cdd:pfam00615  78 ENLEKE---PTRDLFDEAQAEVYELMEKDSYPRFLKSPLYLRL 117
RGS_AKAP2_2 cd08721
Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, ...
 185-302 3.10e-19

Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the second RGS domain.


Pssm-ID: 188676  Cd Length: 121  Bit Score: 83.16  E-value: 3.10e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205371 185 ILKVQPLLLSFLEFIKEKEDHDTIQFLLGCDSFEANLDLMEDS----EALGDAMALYEKYFSMQATNMIDLGSAIRAEME 260
Cdd:cd08721    1 ILYCESALFYFMEYMEQEGARNLLQFWLAADNFQSQLAAKEGQydgqQAQNDAMIIYDKYFSLQATEPLGFDDKTRLEVE 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 193205371 261 SLICEEsGRPNRKAFRTAKTACFFRLHDKYLSDFLKTSYYHN 302
Cdd:cd08721   81 SNICRE-GGPLPSCFEAPLLQALTTLEQHYLPGFLSSQLYYK 121
RGS_AKAP2_1 cd08735
Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, ...
 78-300 1.56e-16

Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the first RGS domain.


Pssm-ID: 188689 [Multi-domain]  Cd Length: 171  Bit Score: 77.11  E-value: 1.56e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205371  78 LAFSLDRLLIDSSALSYFIQYLDSTDKLNLIKFWMHVEGFKSSFSEQIQAAqeyklSASPLQKSCFDEAqdfvkslfeyr 157
Cdd:cd08735    1 LSKTLEQILHDNSALPYFIQFMETRRAEHLIKFWLEAESFKSAAWSRIRAH-----SLNTVKHSSLEEP----------- 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205371 158 yfdefqnSVYYKKHELEVLSDGCSLAdilkvqplllsflefiKEKEDHDTIQfllgcdsfeanldLMEDSEAlgDAMALY 237
Cdd:cd08735   65 -------VSPSLDRKVLESKSTDSLS----------------QRLTDDDDEK-------------SMKSIER--DAVSIY 106

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 193205371 238 EKYFSMQATNMIDLGSAIRAEMESLICEESGRPNRKAFRTAKTACFFRLHDKYLSDFLKTSYY 300
Cdd:cd08735  107 TKYISPDAAKPIPITEEIRNDIVAKICGEDGQVDPNCFVEAQSFVFSAMEQDHFTEFLRSHFF 169
RGS pfam00615
Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for ...
 81-170 2.67e-13

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 459870  Cd Length: 117  Bit Score: 66.10  E-value: 2.67e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205371   81 SLDRLLIDSSALSYFIQYLDSTDKLNLIKFWMHVEGFKSSF--SEQIQAAQE------YKLSASPLQ------------- 139
Cdd:pfam00615   1 SFDSLLEDQPGRRLFRQFLESEFSEENLEFWLACEEFKKADpdEERLKKAKEiyneflAPGSPKEINldsdlreeirenl 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 193205371  140 -----KSCFDEAQDFVKSLFEYRYFDEFQNSVYYKK 170
Cdd:pfam00615  81 ekeptRDLFDEAQAEVYELMEKDSYPRFLKSPLYLR 116
RGS smart00315
Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins ...
 81-171 1.11e-09

Regulator of G protein signalling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.


Pssm-ID: 214613  Cd Length: 118  Bit Score: 55.74  E-value: 1.11e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205371    81 SLDRLLIDSSALSYFIQYLDSTDKLNLIKFWMHVEGFKSSF--SEQIQAAQE-------------------------YKL 133
Cdd:smart00315   1 SLESLLSDPIGRLLFREFLESEFSEENLEFWLAVEEFKKAEddEERIAKAREiydkflspnapkevnldsdlrekieENL 80

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 193205371   134 SASPLQKSCFDEAQDFVKSLFEYRYFDEFQNSVYYKKH 171
Cdd:smart00315  81 ESEEPPPDLFDEAQREVYELLEKDSFPRFLESDYYLRF 118
RGS cd07440
Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ...
 86-170 6.89e-09

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.


Pssm-ID: 188659 [Multi-domain]  Cd Length: 113  Bit Score: 53.55  E-value: 6.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205371  86 LIDSSALSYFIQYLDSTDKLNLIKFWMHVEGFKSS----------------------------FSEQIQAAQEYKLSASP 137
Cdd:cd07440    1 LRDPYGLEYFRQFLKSEHCEENLEFWLAVEKFKKTtssdeelkskakeiydkyiskdapkeinIPESIREEIEENLEEPY 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 193205371 138 LQKSCFDEAQDFVKSLFEYRYFDEFQNSVYYKK 170
Cdd:cd07440   81 PDPDCFDEAQEHILNLLEKDSYPRFLKSDLYLK 113
RGS_SNX13 cd08719
Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein; ...
 86-136 1.09e-08

Regulator of G protein signaling (RGS) domain found in the Sorting Nexin 13 (SNX13) protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the SNX13 (Sorting Nexin 13) protein, a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. The RGS-domain of SNX13 plays a major role through attenuation of Galphas-mediated signaling and regulates endocytic trafficking and degradation of the epidermal growth factor receptor. Snx13-null mice were embryonic lethal around midgestation which supports an essential role for SNX13 in mouse development and regulation of endocytosis dynamics.


Pssm-ID: 188674  Cd Length: 135  Bit Score: 53.57  E-value: 1.09e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 193205371  86 LIDSSALSYFIQYLDSTDKLNLIKFWMHVEGFKSSFSEQIQAAQEYKLSAS 136
Cdd:cd08719    2 LVNNVALSYFIDFMQSVGGQAYLFFWLTVEGYRVSAEQQLSELHLRQRGGE 52
RGS cd07440
Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part ...
 192-300 7.30e-08

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.


Pssm-ID: 188659 [Multi-domain]  Cd Length: 113  Bit Score: 50.47  E-value: 7.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193205371 192 LLSFLEFIKEKEDHDTIQFLLGCDSFEANLDlmEDSEALGDAMALYEKYFSMQATNMIDLGSAIRAEMESLICEESGRPN 271
Cdd:cd07440    7 LEYFRQFLKSEHCEENLEFWLAVEKFKKTTS--SDEELKSKAKEIYDKYISKDAPKEINIPESIREEIEENLEEPYPDPD 84

                         90       100
                 ....*....|....*....|....*....
gi 193205371 272 rkAFRTAKTACFFRLHDKYLSDFLKTSYY 300
Cdd:cd07440   85 --CFDEAQEHILNLLEKDSYPRFLKSDLY 111
RGS_PX cd08729
Regulator of G protein signaling domain; These uncharacterized RGS-like domains are found in ...
 86-137 6.44e-05

Regulator of G protein signaling domain; These uncharacterized RGS-like domains are found in proteins that also contain one or more PX domains. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, the RGS domain containing proteins that are involves in many crucial cellular processes. RGS proteins regulate intracellular trafficking and provide vital support for signal transduction. RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, others RGS proteins play important role in neuronal signals modulation. Some RGS proteins are the principal elements needed for proper vision.


Pssm-ID: 188684  Cd Length: 136  Bit Score: 42.84  E-value: 6.44e-05
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                 ....*....|....*....|....*....|....*....|....*....|..
gi 193205371  86 LIDSSALSYFIQYLDSTDKLNLIKFWMHVEGFKSSFsEQIQAAQEYKLSASP 137
Cdd:cd08729    1 LRDPSSLSYFMEFMDRRNRSQLVQFWLVVEGFKNPL-EDTENDYSLDSSQSR 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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