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Conserved domains on  [gi|193203511|ref|NP_001122542|]
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Malignant brain tumor repeat protein 1 [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MBT super family cl45897
malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes ...
 479-549 1.86e-35

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes methylated lysine residues on histones and are thought to affect a variety of chromatin processes, including transcription. It exists as tandem repeats and is found in a number of nuclear proteins such as Drosophila sex comb on midleg protein. In the human genome, there are at least 9 MBT repeat proteins, each containing two, three or four MBT repeats. MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine (monomethyllysine and/or dimethyllysine).


The actual alignment was detected with superfamily member cd20100:

Pssm-ID: 459242  Cd Length: 71  Bit Score: 127.40  E-value: 1.86e-35
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 193203511 479 HMFEFGRVLEAVGQNETYWISPASVEEVHGRTVLIEFQGWDSEFSELYDMDSHDLLPAGWCEFFNFKLRHP 549
Cdd:cd20100    1 HGFKVGMKLEAVDLMEPRLICVATVTRVVGRLLRVHFDGWDDEFDQWVDCDSPDIYPVGWCELVGYPLQPP 71
MBT_dSfmbt-like_rpt3 cd20099
third malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein ...
 369-460 6.32e-34

third malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


:

Pssm-ID: 439089 [Multi-domain]  Cd Length: 91  Bit Score: 123.95  E-value: 6.32e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193203511 369 LKVGQKFELLDPLSDlrQSFCVATIRKICKtPGFLIISPDETESDDES--FPIHIDNHFMHPVGYAEKFGIKLDRLAGTE 446
Cdd:cd20099    1 FKVGMKLEAVDPLNL--SSICVATVRKVLR-FGYLVIGIDGPSADDGSdwFCCHASSPFIFPVGFAEKNGIELTPPRGYE 77

                         90
                 ....*....|....
gi 193203511 447 PGKFKWEGYLKEKQ 460
Cdd:cd20099   78 SKPFDWEEYLEETG 91
MBT smart00561
Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, ...
 217-326 1.70e-20

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.


:

Pssm-ID: 214723  Cd Length: 96  Bit Score: 86.15  E-value: 1.70e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193203511   217 ELHENRISEPKIFDQlrHLAHRPSRFRLNQRVELLNYLEPTEIRVARILRILGRRLMVMVTAQDypedlpsveakdrqvq 296
Cdd:smart00561   5 EETGARAAPVELFKQ--PVDSPPNGFKVGMKLEAVDPRNPSLICVATVVEVKGYRLLLHFDGWD---------------- 66

                           90       100       110
                   ....*....|....*....|....*....|
gi 193203511   297 hENVEFWVDESSFFLFPVGFAMINGLRTKA 326
Cdd:smart00561  67 -DKYDFWCHADSPDIFPVGWCEKNGHPLQP 95
MBT super family cl45897
malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes ...
 96-164 4.22e-07

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes methylated lysine residues on histones and are thought to affect a variety of chromatin processes, including transcription. It exists as tandem repeats and is found in a number of nuclear proteins such as Drosophila sex comb on midleg protein. In the human genome, there are at least 9 MBT repeat proteins, each containing two, three or four MBT repeats. MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine (monomethyllysine and/or dimethyllysine).


The actual alignment was detected with superfamily member cd20097:

Pssm-ID: 459242  Cd Length: 105  Bit Score: 48.46  E-value: 4.22e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 193203511  96 NQHLKPGFRLEVVVRpslDPSITTKSPEIRWFGEVTAVCGFYVAIKFVG--ELNRRPCWFHMLSEDIFDIG 164
Cdd:cd20097    1 WEKVKIGVKVEVANR---DDDKPTDNVKVYWFARIIKVAGYRVLLRYEGydEDSSHDFWINLCSNEIHPIG 68
 
Name Accession Description Interval E-value
MBT_dSfmbt-like_rpt4 cd20100
fourth malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb ...
 479-549 1.86e-35

fourth malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439090  Cd Length: 71  Bit Score: 127.40  E-value: 1.86e-35
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 193203511 479 HMFEFGRVLEAVGQNETYWISPASVEEVHGRTVLIEFQGWDSEFSELYDMDSHDLLPAGWCEFFNFKLRHP 549
Cdd:cd20100    1 HGFKVGMKLEAVDLMEPRLICVATVTRVVGRLLRVHFDGWDDEFDQWVDCDSPDIYPVGWCELVGYPLQPP 71
MBT_dSfmbt-like_rpt3 cd20099
third malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein ...
 369-460 6.32e-34

third malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439089 [Multi-domain]  Cd Length: 91  Bit Score: 123.95  E-value: 6.32e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193203511 369 LKVGQKFELLDPLSDlrQSFCVATIRKICKtPGFLIISPDETESDDES--FPIHIDNHFMHPVGYAEKFGIKLDRLAGTE 446
Cdd:cd20099    1 FKVGMKLEAVDPLNL--SSICVATVRKVLR-FGYLVIGIDGPSADDGSdwFCCHASSPFIFPVGFAEKNGIELTPPRGYE 77

                         90
                 ....*....|....
gi 193203511 447 PGKFKWEGYLKEKQ 460
Cdd:cd20099   78 SKPFDWEEYLEETG 91
MBT smart00561
Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, ...
 217-326 1.70e-20

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.


Pssm-ID: 214723  Cd Length: 96  Bit Score: 86.15  E-value: 1.70e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193203511   217 ELHENRISEPKIFDQlrHLAHRPSRFRLNQRVELLNYLEPTEIRVARILRILGRRLMVMVTAQDypedlpsveakdrqvq 296
Cdd:smart00561   5 EETGARAAPVELFKQ--PVDSPPNGFKVGMKLEAVDPRNPSLICVATVVEVKGYRLLLHFDGWD---------------- 66

                           90       100       110
                   ....*....|....*....|....*....|
gi 193203511   297 hENVEFWVDESSFFLFPVGFAMINGLRTKA 326
Cdd:smart00561  67 -DKYDFWCHADSPDIFPVGWCEKNGHPLQP 95
MBT smart00561
Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, ...
 453-540 8.07e-19

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.


Pssm-ID: 214723  Cd Length: 96  Bit Score: 81.53  E-value: 8.07e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193203511   453 EGYLKEKQAEKIPDEMLRPlPSKERRHMFEFGRVLEAVGQNETYWISPASVEEVHGRTVLIEFQGWDSEFSELYDMDSHD 532
Cdd:smart00561   1 EDYLEETGARAAPVELFKQ-PVDSPPNGFKVGMKLEAVDPRNPSLICVATVVEVKGYRLLLHFDGWDDKYDFWCHADSPD 79


                   ....*...
gi 193203511   533 LLPAGWCE 540
Cdd:smart00561  80 IFPVGWCE 87
MBT cd20088
malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes ...
 242-318 1.08e-14

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes methylated lysine residues on histones and are thought to affect a variety of chromatin processes, including transcription. It exists as tandem repeats and is found in a number of nuclear proteins such as Drosophila sex comb on midleg protein. In the human genome, there are at least 9 MBT repeat proteins, each containing two, three or four MBT repeats. MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine (monomethyllysine and/or dimethyllysine).


Pssm-ID: 439080  Cd Length: 61  Bit Score: 68.44  E-value: 1.08e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 193203511 242 FRLNQRVELLNYLEPTEIRVARILRILGRRLMVMVTAQDypedlpsveakdrqvqHENVEFWVDESSFFLFPVGFAM 318
Cdd:cd20088    1 FKVGMKLEAVDPLNPSEICVATVVKVVGGRLLLHFDGWD----------------PSRYDFWCDVDSPDIHPVGWCE 61
MBT pfam02820
mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear ...
 487-549 4.52e-14

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.


Pssm-ID: 460712  Cd Length: 66  Bit Score: 67.15  E-value: 4.52e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 193203511  487 LEAVGQNETYWISPASVEEVHGRTVLIEFQGWDSEFSELYDMDSHDLLPAGWCEFFNFKLRHP 549
Cdd:pfam02820   3 LEAVDPLNPSLICVATVVKVLGGRLRLRFDGWDDSYDFWCHADSPDIHPVGWCEKNGHPLQPP 65
MBT pfam02820
mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear ...
 246-321 4.67e-12

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.


Pssm-ID: 460712  Cd Length: 66  Bit Score: 61.37  E-value: 4.67e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 193203511  246 QRVELLNYLEPTEIRVARILRILGRRLMVMVtaQDYPEDLpsveakdrqvqhenvEFWVDESSFFLFPVGFAMING 321
Cdd:pfam02820   1 MKLEAVDPLNPSLICVATVVKVLGGRLRLRF--DGWDDSY---------------DFWCHADSPDIHPVGWCEKNG 59
MBT pfam02820
mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear ...
 373-439 1.18e-11

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.


Pssm-ID: 460712  Cd Length: 66  Bit Score: 60.22  E-value: 1.18e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 193203511  373 QKFELLDPLSdlRQSFCVATIRKICktPGFLIISPDETEsDDESFPIHIDNHFMHPVGYAEKFGIKL 439
Cdd:pfam02820   1 MKLEAVDPLN--PSLICVATVVKVL--GGRLRLRFDGWD-DSYDFWCHADSPDIHPVGWCEKNGHPL 62
MBT_dSfmbt-like_rpt1 cd20097
first malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein ...
 96-164 4.22e-07

first malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439087  Cd Length: 105  Bit Score: 48.46  E-value: 4.22e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 193203511  96 NQHLKPGFRLEVVVRpslDPSITTKSPEIRWFGEVTAVCGFYVAIKFVG--ELNRRPCWFHMLSEDIFDIG 164
Cdd:cd20097    1 WEKVKIGVKVEVANR---DDDKPTDNVKVYWFARIIKVAGYRVLLRYEGydEDSSHDFWINLCSNEIHPIG 68
MBT smart00561
Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, ...
 75-164 3.40e-06

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.


Pssm-ID: 214723  Cd Length: 96  Bit Score: 45.70  E-value: 3.40e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193203511    75 DGNTQFLPVEALEGCLPLEKLNqhLKPGFRLEVVVRpsldpsittKSPEIRWFGEVTAVCGFYVAIKFVGELNRRPCWFH 154
Cdd:smart00561   6 ETGARAAPVELFKQPVDSPPNG--FKVGMKLEAVDP---------RNPSLICVATVVEVKGYRLLLHFDGWDDKYDFWCH 74

                           90
                   ....*....|
gi 193203511   155 MLSEDIFDIG 164
Cdd:smart00561  75 ADSPDIFPVG 84
MBT pfam02820
mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear ...
 104-164 6.10e-03

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.


Pssm-ID: 460712  Cd Length: 66  Bit Score: 35.57  E-value: 6.10e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 193203511  104 RLEVVvrpslDPsittKSPEIRWFGEVTAVCGFYVAIKFVGELNRRPCWFHMLSEDIFDIG 164
Cdd:pfam02820   2 KLEAV-----DP----LNPSLICVATVVKVLGGRLRLRFDGWDDSYDFWCHADSPDIHPVG 53
 
Name Accession Description Interval E-value
MBT_dSfmbt-like_rpt4 cd20100
fourth malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb ...
 479-549 1.86e-35

fourth malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439090  Cd Length: 71  Bit Score: 127.40  E-value: 1.86e-35
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 193203511 479 HMFEFGRVLEAVGQNETYWISPASVEEVHGRTVLIEFQGWDSEFSELYDMDSHDLLPAGWCEFFNFKLRHP 549
Cdd:cd20100    1 HGFKVGMKLEAVDLMEPRLICVATVTRVVGRLLRVHFDGWDDEFDQWVDCDSPDIYPVGWCELVGYPLQPP 71
MBT_dSfmbt-like_rpt3 cd20099
third malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein ...
 369-460 6.32e-34

third malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439089 [Multi-domain]  Cd Length: 91  Bit Score: 123.95  E-value: 6.32e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193203511 369 LKVGQKFELLDPLSDlrQSFCVATIRKICKtPGFLIISPDETESDDES--FPIHIDNHFMHPVGYAEKFGIKLDRLAGTE 446
Cdd:cd20099    1 FKVGMKLEAVDPLNL--SSICVATVRKVLR-FGYLVIGIDGPSADDGSdwFCCHASSPFIFPVGFAEKNGIELTPPRGYE 77

                         90
                 ....*....|....
gi 193203511 447 PGKFKWEGYLKEKQ 460
Cdd:cd20099   78 SKPFDWEEYLEETG 91
MBT smart00561
Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, ...
 217-326 1.70e-20

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.


Pssm-ID: 214723  Cd Length: 96  Bit Score: 86.15  E-value: 1.70e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193203511   217 ELHENRISEPKIFDQlrHLAHRPSRFRLNQRVELLNYLEPTEIRVARILRILGRRLMVMVTAQDypedlpsveakdrqvq 296
Cdd:smart00561   5 EETGARAAPVELFKQ--PVDSPPNGFKVGMKLEAVDPRNPSLICVATVVEVKGYRLLLHFDGWD---------------- 66

                           90       100       110
                   ....*....|....*....|....*....|
gi 193203511   297 hENVEFWVDESSFFLFPVGFAMINGLRTKA 326
Cdd:smart00561  67 -DKYDFWCHADSPDIFPVGWCEKNGHPLQP 95
MBT smart00561
Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, ...
 453-540 8.07e-19

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.


Pssm-ID: 214723  Cd Length: 96  Bit Score: 81.53  E-value: 8.07e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193203511   453 EGYLKEKQAEKIPDEMLRPlPSKERRHMFEFGRVLEAVGQNETYWISPASVEEVHGRTVLIEFQGWDSEFSELYDMDSHD 532
Cdd:smart00561   1 EDYLEETGARAAPVELFKQ-PVDSPPNGFKVGMKLEAVDPRNPSLICVATVVEVKGYRLLLHFDGWDDKYDFWCHADSPD 79


                   ....*...
gi 193203511   533 LLPAGWCE 540
Cdd:smart00561  80 IFPVGWCE 87
MBT cd20088
malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes ...
 242-318 1.08e-14

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes methylated lysine residues on histones and are thought to affect a variety of chromatin processes, including transcription. It exists as tandem repeats and is found in a number of nuclear proteins such as Drosophila sex comb on midleg protein. In the human genome, there are at least 9 MBT repeat proteins, each containing two, three or four MBT repeats. MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine (monomethyllysine and/or dimethyllysine).


Pssm-ID: 439080  Cd Length: 61  Bit Score: 68.44  E-value: 1.08e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 193203511 242 FRLNQRVELLNYLEPTEIRVARILRILGRRLMVMVTAQDypedlpsveakdrqvqHENVEFWVDESSFFLFPVGFAM 318
Cdd:cd20088    1 FKVGMKLEAVDPLNPSEICVATVVKVVGGRLLLHFDGWD----------------PSRYDFWCDVDSPDIHPVGWCE 61
MBT pfam02820
mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear ...
 487-549 4.52e-14

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.


Pssm-ID: 460712  Cd Length: 66  Bit Score: 67.15  E-value: 4.52e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 193203511  487 LEAVGQNETYWISPASVEEVHGRTVLIEFQGWDSEFSELYDMDSHDLLPAGWCEFFNFKLRHP 549
Cdd:pfam02820   3 LEAVDPLNPSLICVATVVKVLGGRLRLRFDGWDDSYDFWCHADSPDIHPVGWCEKNGHPLQPP 65
MBT_L3MBTL2_rpt3 cd20127
third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 372-458 2.66e-13

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439117  Cd Length: 91  Bit Score: 65.62  E-value: 2.66e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193203511 372 GQKFELLDPLSdlRQSFCVATIRKICkTPGFLIISPDETESDDES--FPIHIDNHFMHPVGYAEKFGIKLDRLAGTEPGK 449
Cdd:cd20127    4 GMKLEAIDPLN--LGNICVATVCKVL-LDGYLMIGIDGGPSTDGSdwFCYHASSHAIFPVGFCQKNDIELTPPKGYDAQT 80


                 ....*....
gi 193203511 450 FKWEGYLKE 458
Cdd:cd20127   81 FNWENYLEK 89
MBT_dScm-like_rpt2 cd20092
second malignant brain tumor (MBT) repeat found in the Polycomb protein sex comb on midleg ...
 477-552 8.63e-13

second malignant brain tumor (MBT) repeat found in the Polycomb protein sex comb on midleg family; The Sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, Polycomb protein sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439082  Cd Length: 75  Bit Score: 63.53  E-value: 8.63e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 193203511 477 RRHMFEFGRVLEAVGQNETYWISPASVEEVHGRTVLIEFQGWDSEFSELYDMDSHDLLPAGWCEffnfKLRHPVLP 552
Cdd:cd20092    2 EKNMFKVGMKLEAVDRKNPQLICPATVGDVDGDEIHISFDGWRGAFDYWCRYDSRDIFPVGWCK----KTGHPLQP 73
MBT_L3MBTL2_rpt4 cd20130
fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 479-550 2.47e-12

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439120  Cd Length: 75  Bit Score: 62.32  E-value: 2.47e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 193203511 479 HMFEFGRVLEAVGQNETYWISPASVEEVHGRTVLIEFQGWDSEFSELYDMDSHDLLPAGWCEFFNFKLRHPV 550
Cdd:cd20130    4 HGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDSEYDQWVDCESPDIYPVGWCELTGYQLQPPV 75
MBT pfam02820
mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear ...
 246-321 4.67e-12

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.


Pssm-ID: 460712  Cd Length: 66  Bit Score: 61.37  E-value: 4.67e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 193203511  246 QRVELLNYLEPTEIRVARILRILGRRLMVMVtaQDYPEDLpsveakdrqvqhenvEFWVDESSFFLFPVGFAMING 321
Cdd:pfam02820   1 MKLEAVDPLNPSLICVATVVKVLGGRLRLRF--DGWDDSY---------------DFWCHADSPDIHPVGWCEKNG 59
MBT_L3MBTL1-like_rpt3 cd20103
third malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like ...
 479-552 6.59e-12

third malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.


Pssm-ID: 439093  Cd Length: 73  Bit Score: 61.14  E-value: 6.59e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 193203511 479 HMFEFGRVLEAVGQNETYWISPASVEEVHGRTVLIEFQGWDSEFSELYDMDSHDLLPAGWCEffnfKLRHPVLP 552
Cdd:cd20103    3 HGFEVGMKLEAVDKRNPRLIRVATVADVEDYRVKLHFDGWPDIYDFWVDDDSPDIHPPGWCS----KTGHPLEP 72
MBT_SCMH1_rpt2 cd20108
second malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog ...
 478-549 7.12e-12

second malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1 (SCMH1) and similar proteins; SCMH1 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439098  Cd Length: 75  Bit Score: 61.11  E-value: 7.12e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 193203511 478 RHMFEFGRVLEAVGQNETYWISPASVEEVHGRTVLIEFQGWDSEFSELYDMDSHDLLPAGWCEFFNFKLRHP 549
Cdd:cd20108    3 QNFFKTGMKLEAVDRKNPHFICPATIGEVRGSEVLVTFDGWRGAFDYWCRYDSRDIFPVGWCSLTGDNLQPP 74
MBT pfam02820
mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear ...
 373-439 1.18e-11

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.


Pssm-ID: 460712  Cd Length: 66  Bit Score: 60.22  E-value: 1.18e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 193203511  373 QKFELLDPLSdlRQSFCVATIRKICktPGFLIISPDETEsDDESFPIHIDNHFMHPVGYAEKFGIKL 439
Cdd:pfam02820   1 MKLEAVDPLN--PSLICVATVVKVL--GGRLRLRFDGWD-DSYDFWCHADSPDIHPVGWCEKNGHPL 62
MBT_SCML2_rpt2 cd20109
second malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2 (SCML2) ...
 481-549 1.78e-11

second malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2 (SCML2) and similar proteins; SCML2 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439099  Cd Length: 77  Bit Score: 59.90  E-value: 1.78e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 193203511 481 FEFGRVLEAVGQNETYWISPASVEEVHGRTVLIEFQGWDSEFSELYDMDSHDLLPAGWCEFFNFKLRHP 549
Cdd:cd20109    6 FKVGMKLEAIDKKNPYLICPATIGDVKGDEVFITFDGWRGAFDYWCKYDSRDIFPVGWCRLTGDVLQPP 74
MBT_MBTD1_rpt3 cd20126
third malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); ...
 370-458 7.60e-11

third malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439116  Cd Length: 90  Bit Score: 58.65  E-value: 7.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193203511 370 KVGQKFELLDPLSdlRQSFCVATIRKICKTpGFLIISPDETESDDES--FPIHIDNHFMHPVGYAEKFGIKLdrlagTEP 447
Cdd:cd20126    2 KEGMKLEAIDPLN--LSTICVATVRKVLAN-GYLMIGIDGSEAADGSdwFCYHATSPSIFPVGFCEINMIEL-----TPP 73

                         90
                 ....*....|....*
gi 193203511 448 ----GKFKWEGYLKE 458
Cdd:cd20126   74 rgykKPFKWFDYLRE 88
MBT_SFMBT_rpt4 cd20096
fourth malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein ...
 481-549 1.89e-10

fourth malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439086  Cd Length: 73  Bit Score: 56.86  E-value: 1.89e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193203511 481 FEFGRVLEAVGQNETYWISPASVEEVHGRTVLIEFQGWDSEFSE-LYDMDSHDLLPAGWCEFFNFKLRHP 549
Cdd:cd20096    1 FERGMKLEAVNPENPNQICVATITKVVGPLLWLHLDSEKKLSPNiIVDVESTDIFPVGWCESNGYPLVTP 70
MBT_MBTD1_rpt4 cd20129
fourth malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); ...
 479-549 3.11e-10

fourth malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439119  Cd Length: 71  Bit Score: 56.52  E-value: 3.11e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 193203511 479 HMFEFGRVLEAVGQNETYWISPASVEEVHGRTVLIEFQGWDSEFSELYDMDSHDLLPAGWCEFFNFKLRHP 549
Cdd:cd20129    1 HGFRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQWVDCESPDLYPVGWCQLTGYQLQPP 71
MBT_L3MBTL3_rpt1 cd20132
first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 367-469 4.21e-10

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439122  Cd Length: 101  Bit Score: 56.85  E-value: 4.21e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193203511 367 NLLKVGQKFELLDPlsDLRQSFCVATIRKICktpGFLIISPDETESDDESFPIHIDNHFMHPVGYAEKFGIKLDRLAGTE 446
Cdd:cd20132    4 NGFKVGMKLEGVDP--EHQSMYCVLTVAEVC---GYRIRLHFDGYSDCYDFWVNADSPDIHPVGWCEKTGHKLHPPKGYK 78

                         90       100
                 ....*....|....*....|...
gi 193203511 447 PGKFKWEGYLKEKQAEKIPDEML 469
Cdd:cd20132   79 EEEFNWQSYLKTCKAQAAPKSLF 101
MBT_dSfmbt_rpt4 cd20128
fourth malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...
 479-549 7.39e-10

fourth malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt); dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439118  Cd Length: 72  Bit Score: 55.43  E-value: 7.39e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 193203511 479 HMFEFGRVLEAVGQNETYWISPASVEEVHGRTVLIEFQGWDSEFSELYDMDSHDLLPAGWCEFFNFKLRHP 549
Cdd:cd20128    1 HGFEVGMSLECADLMDPRLVCVATVARVVGRLLKVHFDGWTDEYDQWLDCESADIYPVGWCVLVNHKLEGP 71
MBT_dScm_rpt2 cd20110
second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...
 477-552 7.82e-10

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg (Scm) and similar proteins; Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439100  Cd Length: 75  Bit Score: 55.15  E-value: 7.82e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 193203511 477 RRHMFEFGRVLEAVGQNETYWISPASVEEVHGRTVLIEFQGWDSEFSELYDMDSHDLLPAGWCEffnfKLRHPVLP 552
Cdd:cd20110    2 ESNLFKVGMKLEAVDRKNPHLICPATVGAVKDDQIFVTFDGWRGAFDYWCRYDSRDIFPVGWCA----RSGHPLQP 73
MBT_SFMBT_rpt3 cd20095
third malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein ...
 369-458 8.31e-10

third malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439085  Cd Length: 92  Bit Score: 55.73  E-value: 8.31e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193203511 369 LKVGQKFELLDPLSdlRQSFCVATIRKICKTPGFLIISPDETESDDESFPI--HIDNHFMHPVGYAEKFGIKLDRLAGTE 446
Cdd:cd20095    1 FKVGMKLEALHPKN--PSTICPATVTKVFNEYYFLVEIDDLRPEESEKITFvcHANSPGIFPVGWCAKNGLRLTPPPGYP 78

                         90
                 ....*....|..
gi 193203511 447 PGKFKWEGYLKE 458
Cdd:cd20095   79 KSEFDWDSYLKL 90
MBT_dSfmbt_rpt3 cd20125
third malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...
 369-465 9.31e-10

third malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439115  Cd Length: 107  Bit Score: 56.01  E-value: 9.31e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193203511 369 LKVGQKFELLDPLSdlRQSFCVATIRKICKTpGFLIISPDETESDD---ESFPIHIDNHFMHPVGYAEKFGIKLDRLAGT 445
Cdd:cd20125    1 FKEGMKLEAVDPLN--LSAICVATVMKVLRF-GYLMIRIDSYEPDAsgsDWFCYHESSPCIFPAGFCEVNNITLTPPNGY 77

                         90       100
                 ....*....|....*....|
gi 193203511 446 EPGKFKWEGYLKEKQAEKIP 465
Cdd:cd20125   78 DGRTFTWEGYLRQTGATAAP 97
MBT_L3MBTL1-like_rpt1 cd20101
first malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like ...
 365-469 3.90e-09

first malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.


Pssm-ID: 439091  Cd Length: 101  Bit Score: 54.20  E-value: 3.90e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193203511 365 KLNLLKVGQKFELLDPLsdlRQS-FCVATIRKICktpGFLIISPDETESDDESFPIHIDNHFMHPVGYAEKFGIKLDRLA 443
Cdd:cd20101    2 NKNGFKVGMKLEGIDPK---HPSlFCVLSVAEVR---GYRLRLHFDGYSECYDFWVNADSPDIFPVGWCEKTGHKLQPPK 75

                         90       100
                 ....*....|....*....|....*.
gi 193203511 444 GTEPGKFKWEGYLKEKQAEKIPDEML 469
Cdd:cd20101   76 GYTSETFSWSAYLKLTKAQAAPKHLF 101
MBT_L3MBTL4_rpt1 cd20133
first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 367-465 8.07e-09

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439123  Cd Length: 101  Bit Score: 53.26  E-value: 8.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193203511 367 NLLKVGQKFELLDPLSDlrQSFCVATIRKICktpGFLIISPDETESDDESFPIHIDNHFMHPVGYAEKFGIKLDRLAGTE 446
Cdd:cd20133    4 NGFKVGMRLEGIDPEHP--SLFCVLSVAEVQ---GYRLRLHFDGYSECYDFWVNADSPDIHPVGWCEKTGHKLLPPKGYK 78

                         90
                 ....*....|....*....
gi 193203511 447 PGKFKWEGYLKEKQAEKIP 465
Cdd:cd20133   79 DGEFNWSSYLKTCKAQAAP 97
MBT_L3MBTL1_rpt3 cd20137
third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 479-552 8.78e-09

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.


Pssm-ID: 439127  Cd Length: 75  Bit Score: 52.52  E-value: 8.78e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 193203511 479 HMFEFGRVLEAVGQNETYWISPASVEEVHGRTVLIEFQGWDSEFSELYDMDSHDLLPAGWCEffnfKLRHPVLP 552
Cdd:cd20137    3 HGFQVNMKLEAVDRRNPALIRVASVEDVEDHRIKIHFDGWSHGYDFWIDADHPDIHPAGWCS----KTGHPLQP 72
MBT_L3MBTL1-like_rpt2 cd20102
second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like ...
 478-549 1.16e-08

second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439092  Cd Length: 90  Bit Score: 52.24  E-value: 1.16e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 193203511 478 RHMFEFGRVLEAVGQNETYWISPASVEEVHGRTVLIEFQGWDSEFSELYDMDSHDLLPAGWCEFFNFKLRHP 549
Cdd:cd20102    1 PHGFRVGMKLEAVDRKNPSLICVATVTDVIGNRFLVHFDGWDDSYDYWCDPDSPYIHPVGWCEENGKTLQPP 72
MBT cd20088
malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes ...
 481-540 3.73e-08

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes methylated lysine residues on histones and are thought to affect a variety of chromatin processes, including transcription. It exists as tandem repeats and is found in a number of nuclear proteins such as Drosophila sex comb on midleg protein. In the human genome, there are at least 9 MBT repeat proteins, each containing two, three or four MBT repeats. MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine (monomethyllysine and/or dimethyllysine).


Pssm-ID: 439080  Cd Length: 61  Bit Score: 49.95  E-value: 3.73e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 193203511 481 FEFGRVLEAVGQNETYWISPASVEEVHGRTVLIEFQGWD-SEFSELYDMDSHDLLPAGWCE 540
Cdd:cd20088    1 FKVGMKLEAVDPLNPSEICVATVVKVVGGRLLLHFDGWDpSRYDFWCDVDSPDIHPVGWCE 61
MBT_L3MBTL3_rpt3 cd20138
third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 479-552 5.51e-08

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.


Pssm-ID: 439128  Cd Length: 78  Bit Score: 50.31  E-value: 5.51e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 193203511 479 HMFEFGRVLEAVGQNETYWISPASVEEVHGRTVLIEFQGWDSEFSELYDMDSHDLLPAGWCEffnfKLRHPVLP 552
Cdd:cd20138    7 HGFQKNMKLEVVDKRNPMLIRVATVADTDDHRVKVHFDGWNNCYDYWIDADSPDIHPAGWCA----KTGHPLQP 76
MBT_dSfmbt-like_rpt1 cd20097
first malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein ...
 96-164 4.22e-07

first malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.


Pssm-ID: 439087  Cd Length: 105  Bit Score: 48.46  E-value: 4.22e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 193203511  96 NQHLKPGFRLEVVVRpslDPSITTKSPEIRWFGEVTAVCGFYVAIKFVG--ELNRRPCWFHMLSEDIFDIG 164
Cdd:cd20097    1 WEKVKIGVKVEVANR---DDDKPTDNVKVYWFARIIKVAGYRVLLRYEGydEDSSHDFWINLCSNEIHPIG 68
MBT_L3MBTL1-like_rpt2 cd20102
second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like ...
 367-460 4.54e-07

second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439092  Cd Length: 90  Bit Score: 48.01  E-value: 4.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193203511 367 NLLKVGQKFELLDPL-SDLrqsFCVATIRKIckTPGFLIISPDE-TESDDesFPIHIDNHFMHPVGYAEKFGIKLDRLAG 444
Cdd:cd20102    2 HGFRVGMKLEAVDRKnPSL---ICVATVTDV--IGNRFLVHFDGwDDSYD--YWCDPDSPYIHPVGWCEENGKTLQPPKG 74

                         90
                 ....*....|....*.
gi 193203511 445 TEPGKFKWEGYLKEKQ 460
Cdd:cd20102   75 YSPGNFSWDKYLEETN 90
MBT_L3MBTL4_rpt2 cd20136
second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 481-560 6.25e-07

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439126  Cd Length: 92  Bit Score: 47.69  E-value: 6.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193203511 481 FEFGRVLEAVGQNETYWISPASVEEVHGRTVLIEFQGWDSEFSELYDMDSHDLLPAGWCEFFNFKLrhpVLPVNDPNAEN 560
Cdd:cd20136    5 FQVGMKLEAVDRKNPSLVCVATIADIVEDRLLVHFDNWDDSYDYWCDVNSPYIQPVGWCQENGRTL---VAPQGYPNPEK 81
MBT cd20088
malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes ...
 370-433 6.39e-07

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes methylated lysine residues on histones and are thought to affect a variety of chromatin processes, including transcription. It exists as tandem repeats and is found in a number of nuclear proteins such as Drosophila sex comb on midleg protein. In the human genome, there are at least 9 MBT repeat proteins, each containing two, three or four MBT repeats. MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine (monomethyllysine and/or dimethyllysine).


Pssm-ID: 439080  Cd Length: 61  Bit Score: 46.48  E-value: 6.39e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 193203511 370 KVGQKFELLDPLSDLrqSFCVATIRKICKtpGFLIISPDETESDDESFPIHIDNHFMHPVGYAE 433
Cdd:cd20088    2 KVGMKLEAVDPLNPS--EICVATVVKVVG--GRLLLHFDGWDPSRYDFWCDVDSPDIHPVGWCE 61
MBT_SFMBT2_rpt4 cd20118
fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 ...
 487-557 2.43e-06

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439108  Cd Length: 91  Bit Score: 45.97  E-value: 2.43e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 193203511 487 LEAVGQNETYWISPASVEEVHGRTVLIEFQGWDSEFSE-LYDMDSHDLLPAGWCEFFNFKLRHPVLPVNDPN 557
Cdd:cd20118    8 LEAVNPRNPAEICVASITSVKGRLLWLHLEGLQNPVPEyIVDVESMDIFPVGWCEANGYPLTPPHKAVCKKK 79
MBT_L3MBTL1-like_rpt1 cd20101
first malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like ...
 477-549 2.96e-06

first malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.


Pssm-ID: 439091  Cd Length: 101  Bit Score: 46.11  E-value: 2.96e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 193203511 477 RRHMFEFGRVLEAVGQNETYWISPASVEEVHGRTVLIEFQGWdsefSELYDM----DSHDLLPAGWCEFFNFKLRHP 549
Cdd:cd20101    2 NKNGFKVGMKLEGIDPKHPSLFCVLSVAEVRGYRLRLHFDGY----SECYDFwvnaDSPDIFPVGWCEKTGHKLQPP 74
MBT smart00561
Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, ...
 75-164 3.40e-06

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.


Pssm-ID: 214723  Cd Length: 96  Bit Score: 45.70  E-value: 3.40e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193203511    75 DGNTQFLPVEALEGCLPLEKLNqhLKPGFRLEVVVRpsldpsittKSPEIRWFGEVTAVCGFYVAIKFVGELNRRPCWFH 154
Cdd:smart00561   6 ETGARAAPVELFKQPVDSPPNG--FKVGMKLEAVDP---------RNPSLICVATVVEVKGYRLLLHFDGWDDKYDFWCH 74

                           90
                   ....*....|
gi 193203511   155 MLSEDIFDIG 164
Cdd:smart00561  75 ADSPDIFPVG 84
MBT_L3MBTL4_rpt3 cd20139
fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 479-549 8.38e-06

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.


Pssm-ID: 439129  Cd Length: 82  Bit Score: 44.09  E-value: 8.38e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 193203511 479 HMFEFGRVLEAVGQNETYWISPASVEEVHGRTVLIEFQGWDSEFSELYDMDSHDLLPAGWCEFFNFKLRHP 549
Cdd:cd20139    7 HGFQVNMKLEAVDKRNPILIRVATIVDKDDHRIKLHFDGWDHNYDFWVDADSPDIHPVGWCDKTGHALQVP 77
MBT_L3MBTL1_rpt1 cd20131
first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 367-469 2.54e-05

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.


Pssm-ID: 439121  Cd Length: 109  Bit Score: 43.71  E-value: 2.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193203511 367 NLLKVGQKFELLDPLSDlrQSFCVATIRKICktpGFLIISPDETESDDESFPIHIDNHFMHPVGYAEKFGIKLDRLAGTE 446
Cdd:cd20131   12 NGFKLGMKLEGIDPQHP--SMYFILTVAEVC---GYRLRLHFDGYSECHDFWVNANSPDIHPAGWFEKTGHKLQPPKGYK 86

                         90       100
                 ....*....|....*....|...
gi 193203511 447 PGKFKWEGYLKEKQAEKIPDEML 469
Cdd:cd20131   87 EEEFSWSQYLRSTRAQAAPKHLF 109
MBT_dSfmbt-like_rpt3 cd20099
third malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein ...
 242-330 7.99e-05

third malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439089 [Multi-domain]  Cd Length: 91  Bit Score: 41.52  E-value: 7.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193203511 242 FRLNQRVELLNYLEPTEIRVARILRILGRRLMVmvtaqdypedlpsVEAKDRQVQHENVEFWVDESSFFLFPVGFAMING 321
Cdd:cd20099    1 FKVGMKLEAVDPLNLSSICVATVRKVLRFGYLV-------------IGIDGPSADDGSDWFCCHASSPFIFPVGFAEKNG 67


                 ....*....
gi 193203511 322 LRTKATEGY 330
Cdd:cd20099   68 IELTPPRGY 76
MBT_dSfmbt_rpt2 cd20122
second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...
 240-327 1.34e-04

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439112  Cd Length: 83  Bit Score: 40.60  E-value: 1.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193203511 240 SRFRLNQRVELLNYLEPTEIRVARILRILGRRLMVMVtaqdypEDLPSVEAKdrqvqhenveFWVDESSFFLFPVGFAMI 319
Cdd:cd20122   12 SRFRLGLNLECVDKNRISQVRVATVTKIVGKRLHLRY------EGSEPDDDG----------FWCHEDSPLIHPVGWAQT 75


                 ....*...
gi 193203511 320 NGLRTKAT 327
Cdd:cd20122   76 VGHNLAAS 83
MBT_L3MBTL1_rpt2 cd20134
second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 480-560 2.28e-04

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439124  Cd Length: 93  Bit Score: 40.20  E-value: 2.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193203511 480 MFEFGRVLEAVGQNETYWISPASVEEVHGRTVLIEFQGWDSEFSELYDMDSHDLLPAGWCEffnfKLRHPVLPVND-PNA 558
Cdd:cd20134    5 GFQVGMKLEAVDRMNPSLVCVASVTDVVDSRFLVHFDNWDDTYDYWCDPSSPYIHPVGWCQ----KQGKPLTPPQDyPDP 80


                 ..
gi 193203511 559 EN 560
Cdd:cd20134   81 DN 82
MBT_SFMBT1_rpt3 cd20115
third malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 ...
 371-458 2.45e-04

third malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439105  Cd Length: 94  Bit Score: 40.24  E-value: 2.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193203511 371 VGQKFELLDPLSDLRQSfcVATIRKICKTPGFLIISPD--ETESDDESFPIHIDNHFMHPVGYAEKFGIKLDRLAGTEPG 448
Cdd:cd20115    5 EGMKLEAVDPAAPFTIS--PATVAKVFNEKFFLVEMDDlrPEEAGAHSFVCHRDSPGIFPVQWSLKNGLHLSPPPGYPGQ 82

                         90
                 ....*....|
gi 193203511 449 KFKWEGYLKE 458
Cdd:cd20115   83 DFDWADYLKQ 92
MBT_L3MBTL4_rpt1 cd20133
first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 476-549 6.62e-04

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439123  Cd Length: 101  Bit Score: 39.39  E-value: 6.62e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 193203511 476 ERRHMFEFGRVLEAVGQNETYWISPASVEEVHGRTVLIEFQGwdseFSELYDM----DSHDLLPAGWCEFFNFKLRHP 549
Cdd:cd20133    1 QSRNGFKVGMRLEGIDPEHPSLFCVLSVAEVQGYRLRLHFDG----YSECYDFwvnaDSPDIHPVGWCEKTGHKLLPP 74
MBT_L3MBTL3_rpt2 cd20135
second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 370-458 9.25e-04

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439125  Cd Length: 93  Bit Score: 38.63  E-value: 9.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193203511 370 KVGQKFELLDP--LSDLrqsfCVATIrkicktpgfliispdeTESDDESFPIHIDN-------------HFMHPVGYAEK 434
Cdd:cd20135    7 RVGMKLEAVDKknPSFI----CVATI----------------TDMVDNRLLIHFDNwdesydywcdassPYIHPVGYCQE 66

                         90       100
                 ....*....|....*....|....*
gi 193203511 435 FGIKLDRLAG-TEPGKFKWEGYLKE 458
Cdd:cd20135   67 HGRTLTTPPGyKDPKHFSWEKYLEE 91
MBT_SFMBT2_rpt3 cd20116
three malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 ...
 369-460 3.26e-03

three malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439106  Cd Length: 93  Bit Score: 37.09  E-value: 3.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193203511 369 LKVGQKFELLDPLSDLrqSFCVATIRKICKTPGFLIISPD-ETESDDESFPIHIDNHFMHPVGYAEKFGIKLDRLAGTEP 447
Cdd:cd20116    3 FTVGMKLEVVDPREPF--HICPASVTKVFNNHYFQVTVDDlRPEASENSMLCHADSLGILPVQWCLKNGVNLTPPKGYSG 80

                         90
                 ....*....|...
gi 193203511 448 GKFKWEGYLKEKQ 460
Cdd:cd20116   81 QDFDWADYQKQCG 93
MBT_SFMBT_rpt4 cd20096
fourth malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein ...
 242-321 3.50e-03

fourth malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439086  Cd Length: 73  Bit Score: 36.45  E-value: 3.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193203511 242 FRLNQRVELLNYLEPTEIRVARILRILGRRLMVmvtaqdYPEDLPSveakdrqvqhENVEFWVDESSFFLFPVGFAMING 321
Cdd:cd20096    1 FERGMKLEAVNPENPNQICVATITKVVGPLLWL------HLDSEKK----------LSPNIIVDVESTDIFPVGWCESNG 64
MBT_SFMBT1_rpt4 cd20117
fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 ...
 479-549 3.80e-03

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439107  Cd Length: 90  Bit Score: 36.78  E-value: 3.80e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 193203511 479 HMFEFGRVLEAVGQNETYWISPASVEEVHGRTVLIEFQGWDSEFSE-LYDMDSHDLLPAGWCEFFNFKLRHP 549
Cdd:cd20117    1 HCFKENMKLEAVNPICPEEICVATVTKVKGSYLWLQLEGSKKPIPEcIVHVESMDIFPVGWCETNGYPLLHP 72
MBT_dSfmbt_rpt2 cd20122
second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...
 370-440 4.60e-03

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439112  Cd Length: 83  Bit Score: 36.36  E-value: 4.60e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 193203511 370 KVGQKFELLDP--LSDLRqsfcVATIRKIckTPGFLIISPDETESDDESFPIHIDNHFMHPVGYAEKFGIKLD 440
Cdd:cd20122   15 RLGLNLECVDKnrISQVR----VATVTKI--VGKRLHLRYEGSEPDDDGFWCHEDSPLIHPVGWAQTVGHNLA 81
MBT_L3MBTL3_rpt1 cd20132
first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...
 481-549 5.68e-03

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.


Pssm-ID: 439122  Cd Length: 101  Bit Score: 36.44  E-value: 5.68e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 193203511 481 FEFGRVLEAVGQNETYWISPASVEEVHGRTVLIEFQGwdseFSELYDM----DSHDLLPAGWCEFFNFKLrHP 549
Cdd:cd20132    6 FKVGMKLEGVDPEHQSMYCVLTVAEVCGYRIRLHFDG----YSDCYDFwvnaDSPDIHPVGWCEKTGHKL-HP 73
MBT pfam02820
mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear ...
 104-164 6.10e-03

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.


Pssm-ID: 460712  Cd Length: 66  Bit Score: 35.57  E-value: 6.10e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 193203511  104 RLEVVvrpslDPsittKSPEIRWFGEVTAVCGFYVAIKFVGELNRRPCWFHMLSEDIFDIG 164
Cdd:pfam02820   2 KLEAV-----DP----LNPSLICVATVVKVLGGRLRLRFDGWDDSYDFWCHADSPDIHPVG 53
MBT_SFMBT_rpt3 cd20095
third malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein ...
 242-330 7.03e-03

third malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.


Pssm-ID: 439085  Cd Length: 92  Bit Score: 36.08  E-value: 7.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193203511 242 FRLNQRVELLNYLEPTEIRVARILRILGRRlMVMVTAQDYPEDlpsveakdrqvQHENVEFWVDESSFFLFPVGFAMING 321
Cdd:cd20095    1 FKVGMKLEALHPKNPSTICPATVTKVFNEY-YFLVEIDDLRPE-----------ESEKITFVCHANSPGIFPVGWCAKNG 68


                 ....*....
gi 193203511 322 LRTKATEGY 330
Cdd:cd20095   69 LRLTPPPGY 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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