NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|190610034|ref|NP_001122069|]
View 

G patch domain and ankyrin repeat-containing protein 1 isoform 2 [Mus musculus]

Protein Classification

ankyrin repeat domain-containing protein; ankyrin repeat and MYND domain-containing protein( domain architecture ID 12122224)

ankyrin repeat (ANK) domain-containing protein mediates specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions| ankyrin repeat and MYND domain-containing protein similar to ANKMY2 that may be involved in the trafficking of signaling proteins to the cilia

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 248-292 1.96e-13

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


:

Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 63.68  E-value: 1.96e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 190610034  248 TSSPGFRLLLRGGWEPGMGLGPRGEGRANPIPTILKRDQEGLGYR 292
Cdd:pfam01585   1 TSNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLGAE 45
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
99-205 8.59e-13

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 68.06  E-value: 8.59e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610034  99 ILLAAQNGDLTELRRLLEpqeaggAGGNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAwVGVCDLGGRDAAQLAEEA 178
Cdd:COG0666  157 LHLAAANGNLEIVKLLLE------AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD-VNAKDNDGKTALDLAAEN 229

                         90       100
                 ....*....|....*....|....*..
gi 190610034 179 GFPEVARMVREsHGETRSPENQNRSTP 205
Cdd:COG0666  230 GNLEIVKLLLE-AGADLNAKDKDGLTA 255
 
Name Accession Description Interval E-value
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 248-292 1.96e-13

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 63.68  E-value: 1.96e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 190610034  248 TSSPGFRLLLRGGWEPGMGLGPRGEGRANPIPTILKRDQEGLGYR 292
Cdd:pfam01585   1 TSNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLGAE 45
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
99-205 8.59e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 68.06  E-value: 8.59e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610034  99 ILLAAQNGDLTELRRLLEpqeaggAGGNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAwVGVCDLGGRDAAQLAEEA 178
Cdd:COG0666  157 LHLAAANGNLEIVKLLLE------AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD-VNAKDNDGKTALDLAAEN 229

                         90       100
                 ....*....|....*....|....*..
gi 190610034 179 GFPEVARMVREsHGETRSPENQNRSTP 205
Cdd:COG0666  230 GNLEIVKLLLE-AGADLNAKDKDGLTA 255
G_patch smart00443
glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in ...
 246-291 1.90e-12

glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in the splicing factor 45, SON DNA binding protein and D-type Retrovirus- polyproteins.


Pssm-ID: 197727 [Multi-domain]  Cd Length: 47  Bit Score: 61.02  E-value: 1.90e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 190610034   246 VPTSSPGFRLLLRGGWEPGMGLGPRGEGRANPIPTILKRDQEGLGY 291
Cdd:smart00443   1 ISTSNIGAKLLRKMGWKEGQGLGKNEQGIVEPISAEIKKDRKGLGA 46
Ank_2 pfam12796
Ankyrin repeats (3 copies);
99-186 1.18e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 54.74  E-value: 1.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610034   99 ILLAAQNGDLTELRRLLEpqeaggAGGNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAWvgvCDLGGRDAAQLAEEA 178
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLE------NGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN---LKDNGRTALHYAARS 71


                  ....*...
gi 190610034  179 GFPEVARM 186
Cdd:pfam12796  72 GHLEIVKL 79
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 103-239 1.31e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 40.65  E-value: 1.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610034 103 AQNGDLTELRRLLEpqeaGGAggNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAwVGVCDLGGRDAAQLAEEAGFPE 182
Cdd:PTZ00322  90 AASGDAVGARILLT----GGA--DPNCRDYDGRTPLHIACANGHVQVVRVLLEFGAD-PTLLDKDGKTPLELAEENGFRE 162

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 190610034 183 VARM-----VRESHGETRSPENQNRSTPSSsqfcedcgahFEDSnhhTSTAHLLSLSRRPQP 239
Cdd:PTZ00322 163 VVQLlsrhsQCHFELGANAKPDSFTGKPPS----------LEDS---PISSHHPDFSAVPQP 211
 
Name Accession Description Interval E-value
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 248-292 1.96e-13

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 63.68  E-value: 1.96e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 190610034  248 TSSPGFRLLLRGGWEPGMGLGPRGEGRANPIPTILKRDQEGLGYR 292
Cdd:pfam01585   1 TSNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLGAE 45
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
99-205 8.59e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 68.06  E-value: 8.59e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610034  99 ILLAAQNGDLTELRRLLEpqeaggAGGNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAwVGVCDLGGRDAAQLAEEA 178
Cdd:COG0666  157 LHLAAANGNLEIVKLLLE------AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD-VNAKDNDGKTALDLAAEN 229

                         90       100
                 ....*....|....*....|....*..
gi 190610034 179 GFPEVARMVREsHGETRSPENQNRSTP 205
Cdd:COG0666  230 GNLEIVKLLLE-AGADLNAKDKDGLTA 255
G_patch smart00443
glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in ...
 246-291 1.90e-12

glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in the splicing factor 45, SON DNA binding protein and D-type Retrovirus- polyproteins.


Pssm-ID: 197727 [Multi-domain]  Cd Length: 47  Bit Score: 61.02  E-value: 1.90e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 190610034   246 VPTSSPGFRLLLRGGWEPGMGLGPRGEGRANPIPTILKRDQEGLGY 291
Cdd:smart00443   1 ISTSNIGAKLLRKMGWKEGQGLGKNEQGIVEPISAEIKKDRKGLGA 46
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
99-186 3.44e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 66.13  E-value: 3.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610034  99 ILLAAQNGDLTELRRLLEpqeaggAGGNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAwVGVCDLGGRDAAQLAEEA 178
Cdd:COG0666   91 LHAAARNGDLEIVKLLLE------AGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGAD-VNAQDNDGNTPLHLAAAN 163


                 ....*...
gi 190610034 179 GFPEVARM 186
Cdd:COG0666  164 GNLEIVKL 171
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
99-186 1.16e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 64.59  E-value: 1.16e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610034  99 ILLAAQNGDLTELRRLLEpqeaggAGGNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAwVGVCDLGGRDAAQLAEEA 178
Cdd:COG0666  124 LHLAAYNGNLEIVKLLLE------AGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGAD-VNARDNDGETPLHLAAEN 196


                 ....*...
gi 190610034 179 GFPEVARM 186
Cdd:COG0666  197 GHLEIVKL 204
Ank_2 pfam12796
Ankyrin repeats (3 copies);
99-186 1.18e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 54.74  E-value: 1.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610034   99 ILLAAQNGDLTELRRLLEpqeaggAGGNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAWvgvCDLGGRDAAQLAEEA 178
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLE------NGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN---LKDNGRTALHYAARS 71


                  ....*...
gi 190610034  179 GFPEVARM 186
Cdd:pfam12796  72 GHLEIVKL 79
Ank_4 pfam13637
Ankyrin repeats (many copies);
99-154 7.98e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 45.34  E-value: 7.98e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 190610034   99 ILLAAQNGDLTELRRLLEpqeaggAGGNINARDAFWWTPLMCAARAGQGAAVRYLL 154
Cdd:pfam13637   5 LHAAAASGHLELLRLLLE------KGADINAVDGNGETALHFAASNGNVEVLKLLL 54
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
101-186 1.58e-06

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 49.18  E-value: 1.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610034 101 LAAQNGDLTELRRLLEpqeaggAGGNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAWVGVCDLGGRDAAQLAEEAGF 180
Cdd:COG0666  192 LAAENGHLEIVKLLLE------AGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAA 265


                 ....*.
gi 190610034 181 PEVARM 186
Cdd:COG0666  266 LIVKLL 271
Ank_2 pfam12796
Ankyrin repeats (3 copies);
99-158 7.82e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 43.95  E-value: 7.82e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610034   99 ILLAAQNGDLTELRRLLEpqeaggaGGNINARDAFWwTPLMCAARAGQGAAVRYLLGRGA 158
Cdd:pfam12796  34 LHLAAKNGHLEIVKLLLE-------HADVNLKDNGR-TALHYAARSGHLEIVKLLLEKGA 85
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
88-186 8.98e-06

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 46.87  E-value: 8.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610034  88 ALEDEDRMAQWILLAAQNGDLTELRRLLEpqeagGAGGNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAwVGVCDLG 167
Cdd:COG0666   46 ALALADALGALLLLAAALAGDLLVALLLL-----AAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGAD-VNARDKD 119

                         90
                 ....*....|....*....
gi 190610034 168 GRDAAQLAEEAGFPEVARM 186
Cdd:COG0666  120 GETPLHLAAYNGNLEIVKL 138
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 103-239 1.31e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 40.65  E-value: 1.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190610034 103 AQNGDLTELRRLLEpqeaGGAggNINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAwVGVCDLGGRDAAQLAEEAGFPE 182
Cdd:PTZ00322  90 AASGDAVGARILLT----GGA--DPNCRDYDGRTPLHIACANGHVQVVRVLLEFGAD-PTLLDKDGKTPLELAEENGFRE 162

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 190610034 183 VARM-----VRESHGETRSPENQNRSTPSSsqfcedcgahFEDSnhhTSTAHLLSLSRRPQP 239
Cdd:PTZ00322 163 VVQLlsrhsQCHFELGANAKPDSFTGKPPS----------LEDS---PISSHHPDFSAVPQP 211
Ank_5 pfam13857
Ankyrin repeats (many copies);
126-175 4.99e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.01  E-value: 4.99e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 190610034  126 NINARDAFWWTPLMCAARAGQGAAVRYLLGRGAAWvGVCDLGGRDAAQLA 175
Cdd:pfam13857   8 DLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDL-NLKDEEGLTALDLA 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH