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Conserved domains on  [gi|189339194|ref|NP_001121552|]
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tetraspanin-32 isoform a [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHEMX_like_LEL cd03153
Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. ...
 113-228 5.36e-44

Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Phemx (pan hematopoietic expression) or TSSC6 may play a role in hematopoietic cell function.


:

Pssm-ID: 239406  Cd Length: 87  Bit Score: 143.43  E-value: 5.36e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189339194 113 FYNPTQVEDAVLDTYDFVYDQAMKSPSSNWWQELAVIQDTFLCCGKKSPFGLLVSTGAIMCQGREAMREdclqsirnvlw 192
Cdd:cd03153    1 LHSPTQVEDAVLDTYDLVYEQALKSISGSVRQELAAIQDTFLCCGKKSPFGLLGSTGATLCQGGEAMRE----------- 69

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 189339194 193 thysiasiltctslaltvYAMMLCAFLWFAIHSYHG 228
Cdd:cd03153   70 ------------------VAMLLCLFLWFAILSGHG 87
Tetraspanin super family cl28961
Tetraspanin family;
11-157 4.28e-03

Tetraspanin family;


The actual alignment was detected with superfamily member pfam00335:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 37.30  E-value: 4.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189339194   11 KCQILITNFLVLLLGLSMATMVVVIHFGDHFTVIGHASLERnpyetlryWAFYVGISLAGLLSLGAALSTIATVREAHGL 90
Cdd:pfam00335   2 KYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSEASA--------YIPILLIVLGAVIFLVGFLGCCGALKENRCL 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 189339194   91 MAAGFLCFALSFCILVQVAFWRFYNPTQ--------VEDAVLDTYDFVYDQAMKSPSSnwwqeLAVIQDTFLCCG 157
Cdd:pfam00335  74 LLTYFVLLLLLFLAELAAGILAFVYRDKlsgllsnwLKKSLEDGYRDWLDLYSCLNSA-----LDSLQSEFGCCG 143
 
Name Accession Description Interval E-value
PHEMX_like_LEL cd03153
Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. ...
 113-228 5.36e-44

Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Phemx (pan hematopoietic expression) or TSSC6 may play a role in hematopoietic cell function.


Pssm-ID: 239406  Cd Length: 87  Bit Score: 143.43  E-value: 5.36e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189339194 113 FYNPTQVEDAVLDTYDFVYDQAMKSPSSNWWQELAVIQDTFLCCGKKSPFGLLVSTGAIMCQGREAMREdclqsirnvlw 192
Cdd:cd03153    1 LHSPTQVEDAVLDTYDLVYEQALKSISGSVRQELAAIQDTFLCCGKKSPFGLLGSTGATLCQGGEAMRE----------- 69

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 189339194 193 thysiasiltctslaltvYAMMLCAFLWFAIHSYHG 228
Cdd:cd03153   70 ------------------VAMLLCLFLWFAILSGHG 87
Tetraspanin pfam00335
Tetraspanin family;
11-157 4.28e-03

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 37.30  E-value: 4.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189339194   11 KCQILITNFLVLLLGLSMATMVVVIHFGDHFTVIGHASLERnpyetlryWAFYVGISLAGLLSLGAALSTIATVREAHGL 90
Cdd:pfam00335   2 KYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSEASA--------YIPILLIVLGAVIFLVGFLGCCGALKENRCL 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 189339194   91 MAAGFLCFALSFCILVQVAFWRFYNPTQ--------VEDAVLDTYDFVYDQAMKSPSSnwwqeLAVIQDTFLCCG 157
Cdd:pfam00335  74 LLTYFVLLLLLFLAELAAGILAFVYRDKlsgllsnwLKKSLEDGYRDWLDLYSCLNSA-----LDSLQSEFGCCG 143
 
Name Accession Description Interval E-value
PHEMX_like_LEL cd03153
Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. ...
 113-228 5.36e-44

Tetraspanin, extracellular domain or large extracellular loop (LEL), PHEMX_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Phemx (pan hematopoietic expression) or TSSC6 may play a role in hematopoietic cell function.


Pssm-ID: 239406  Cd Length: 87  Bit Score: 143.43  E-value: 5.36e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189339194 113 FYNPTQVEDAVLDTYDFVYDQAMKSPSSNWWQELAVIQDTFLCCGKKSPFGLLVSTGAIMCQGREAMREdclqsirnvlw 192
Cdd:cd03153    1 LHSPTQVEDAVLDTYDLVYEQALKSISGSVRQELAAIQDTFLCCGKKSPFGLLGSTGATLCQGGEAMRE----------- 69

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 189339194 193 thysiasiltctslaltvYAMMLCAFLWFAIHSYHG 228
Cdd:cd03153   70 ------------------VAMLLCLFLWFAILSGHG 87
CD81_like_LEL cd03151
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. ...
 113-191 7.18e-05

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD81, also referred to as Target for anti-proliferative antigen-1, TAPA-1, is found in virtually all tissues, may be involved in regulation of cell growth and has been described as a member of the CD19/CD21/Leu-13 signal transduction complex identified on B cells (the B-Cell co-receptor).


Pssm-ID: 239404  Cd Length: 84  Bit Score: 40.48  E-value: 7.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189339194 113 FYNPTQVEDAVLDTYDFVYDQAMKSPSSNWWQELAVIQDTFLCCGKKSPFGLLVSTGAIMC-QGREAMREDCLQSIRNVL 191
Cdd:cd03151    1 FINKDQIIKEVQNFYDSAYQDAVTDTRSKGTAVLKTFHSTLDCCGKGNLTALLSLLSTDLCpKKLLLDTKDCHQEIDDLF 80
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 113-195 5.02e-04

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 38.25  E-value: 5.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189339194 113 FYNPTQVEDAVLDTYDfvydQAMKSPSSNWW--QELAVIQDTFLCCGKKSPFGLLVSTGAIM---CQGREAM------RE 181
Cdd:cd03127    1 FVYRDQLESLVSDTLN----DAWDEYYVDDDfqEAMDALQSTFECCGVNGPTDYLDLRLLVPsscCKGTDGNcglnlyTE 76

                         90
                 ....*....|....
gi 189339194 182 DCLQSIRNVLWTHY 195
Cdd:cd03127   77 GCLEKLVDFLRSNL 90
Tetraspanin pfam00335
Tetraspanin family;
11-157 4.28e-03

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 37.30  E-value: 4.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189339194   11 KCQILITNFLVLLLGLSMATMVVVIHFGDHFTVIGHASLERnpyetlryWAFYVGISLAGLLSLGAALSTIATVREAHGL 90
Cdd:pfam00335   2 KYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSEASA--------YIPILLIVLGAVIFLVGFLGCCGALKENRCL 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 189339194   91 MAAGFLCFALSFCILVQVAFWRFYNPTQ--------VEDAVLDTYDFVYDQAMKSPSSnwwqeLAVIQDTFLCCG 157
Cdd:pfam00335  74 LLTYFVLLLLLFLAELAAGILAFVYRDKlsgllsnwLKKSLEDGYRDWLDLYSCLNSA-----LDSLQSEFGCCG 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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