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Conserved domains on  [gi|187937034|ref|NP_001120774|]
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mediator of RNA polymerase II transcription subunit 9 [Rattus norvegicus]

Protein Classification

mediator of RNA polymerase II transcription subunit 9( domain architecture ID 19137921)

mediator of RNA polymerase II transcription subunit 9 is a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Med9-C cd21431
Mediator complex subunit 9 (Med9) C-terminal domain family; Med9 is a member of the Middle ...
 56-133 2.75e-28

Mediator complex subunit 9 (Med9) C-terminal domain family; Med9 is a member of the Middle module transcriptional mediator complex which has a species-specific amino-terminal and a well-conserved carboxy-terminal half. Med9 carboxy-terminal has a fundamental function involved in direct binding to other Med proteins and the assembly of Med9 into the Middle module. Med9 amino terminal plays a regulatory role in transcriptional regulation. Mediator co-activator complex plays an essential role in regulation of RNA polymerase II transcription in all eukaryotes.


:

Pssm-ID: 467847  Cd Length: 82  Bit Score: 99.41  E-value: 2.75e-28
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 187937034  56 EENYSFLPLVHNVIkcMDKDSPDLHQDLNALKTKFQEMRKLIGTMPGIHVSPEQQQQQLHSLREQVRTKNELLQKYKS 133
Cdd:cd21431    7 HRLLSFLPLVHNRI--MDKTSKIVHQLKNCLKTKFQKARKMESLMPGIDESPEIIQQQEQRLREKVRTLNDLLQKYKS 82
 
Name Accession Description Interval E-value
Med9-C cd21431
Mediator complex subunit 9 (Med9) C-terminal domain family; Med9 is a member of the Middle ...
 56-133 2.75e-28

Mediator complex subunit 9 (Med9) C-terminal domain family; Med9 is a member of the Middle module transcriptional mediator complex which has a species-specific amino-terminal and a well-conserved carboxy-terminal half. Med9 carboxy-terminal has a fundamental function involved in direct binding to other Med proteins and the assembly of Med9 into the Middle module. Med9 amino terminal plays a regulatory role in transcriptional regulation. Mediator co-activator complex plays an essential role in regulation of RNA polymerase II transcription in all eukaryotes.


Pssm-ID: 467847  Cd Length: 82  Bit Score: 99.41  E-value: 2.75e-28
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 187937034  56 EENYSFLPLVHNVIkcMDKDSPDLHQDLNALKTKFQEMRKLIGTMPGIHVSPEQQQQQLHSLREQVRTKNELLQKYKS 133
Cdd:cd21431    7 HRLLSFLPLVHNRI--MDKTSKIVHQLKNCLKTKFQKARKMESLMPGIDESPEIIQQQEQRLREKVRTLNDLLQKYKS 82
Med9 pfam07544
RNA polymerase II transcription mediator complex subunit 9; This family of Med9 proteins is ...
 60-135 1.68e-21

RNA polymerase II transcription mediator complex subunit 9; This family of Med9 proteins is conserved in yeasts. It forms part of the middle region of Mediator. Med9 has two functional domains. The species-specific amino-terminal half (aa 1-63) plays a regulatory role in transcriptional regulation, whereas this well-conserved carboxy-terminal half (aa 64-149) has a more fundamental function involved in direct binding to the amino-terminal portions of Med4 and Med7 and the assembly of Med9 into the Middle module. Also, some unidentified factor(s) in med9 extracts may impact the binding of TFIID to the promoter.


Pssm-ID: 462202  Cd Length: 80  Bit Score: 81.86  E-value: 1.68e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187937034   60 SFLPLVHNVIKCMDKD----SPDLHQDLNALKTKFQEMRKLIGTMPGIHVSPEQQQQQLHSLREQVRTKNELLQKYKSLC 135
Cdd:pfam07544   1 EFLPLIFDILKSIEKDpnlsSKDLDTATGELRHKLQKARALIRELPGIDRSVEEQEAEIENLEQQLARKRELLKKYKNRV 80
 
Name Accession Description Interval E-value
Med9-C cd21431
Mediator complex subunit 9 (Med9) C-terminal domain family; Med9 is a member of the Middle ...
 56-133 2.75e-28

Mediator complex subunit 9 (Med9) C-terminal domain family; Med9 is a member of the Middle module transcriptional mediator complex which has a species-specific amino-terminal and a well-conserved carboxy-terminal half. Med9 carboxy-terminal has a fundamental function involved in direct binding to other Med proteins and the assembly of Med9 into the Middle module. Med9 amino terminal plays a regulatory role in transcriptional regulation. Mediator co-activator complex plays an essential role in regulation of RNA polymerase II transcription in all eukaryotes.


Pssm-ID: 467847  Cd Length: 82  Bit Score: 99.41  E-value: 2.75e-28
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 187937034  56 EENYSFLPLVHNVIkcMDKDSPDLHQDLNALKTKFQEMRKLIGTMPGIHVSPEQQQQQLHSLREQVRTKNELLQKYKS 133
Cdd:cd21431    7 HRLLSFLPLVHNRI--MDKTSKIVHQLKNCLKTKFQKARKMESLMPGIDESPEIIQQQEQRLREKVRTLNDLLQKYKS 82
Med9 pfam07544
RNA polymerase II transcription mediator complex subunit 9; This family of Med9 proteins is ...
 60-135 1.68e-21

RNA polymerase II transcription mediator complex subunit 9; This family of Med9 proteins is conserved in yeasts. It forms part of the middle region of Mediator. Med9 has two functional domains. The species-specific amino-terminal half (aa 1-63) plays a regulatory role in transcriptional regulation, whereas this well-conserved carboxy-terminal half (aa 64-149) has a more fundamental function involved in direct binding to the amino-terminal portions of Med4 and Med7 and the assembly of Med9 into the Middle module. Also, some unidentified factor(s) in med9 extracts may impact the binding of TFIID to the promoter.


Pssm-ID: 462202  Cd Length: 80  Bit Score: 81.86  E-value: 1.68e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187937034   60 SFLPLVHNVIKCMDKD----SPDLHQDLNALKTKFQEMRKLIGTMPGIHVSPEQQQQQLHSLREQVRTKNELLQKYKSLC 135
Cdd:pfam07544   1 EFLPLIFDILKSIEKDpnlsSKDLDTATGELRHKLQKARALIRELPGIDRSVEEQEAEIENLEQQLARKRELLKKYKNRV 80
Med21 pfam11221
Subunit 21 of Mediator complex; Med21 has been known as Srb7 in yeasts, hSrb7 in humans and ...
 89-130 7.21e-05

Subunit 21 of Mediator complex; Med21 has been known as Srb7 in yeasts, hSrb7 in humans and Trap 19 in Drosophila. The heterodimer of the two subunits Med7 and Med21 appears to act as a hinge between the middle and the tail regions of Mediator.


Pssm-ID: 463241  Cd Length: 134  Bit Score: 39.88  E-value: 7.21e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 187937034   89 KFQEMRKLIGTMPGIHVSPEQQQQQLHSLREQVRTKNELLQK 130
Cdd:pfam11221  72 KAQQIEYLIDSLPGIGVSEEEQLQRIKELEEELREAEEERQE 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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