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Conserved domains on  [gi|187829452|ref|NP_001120703|]
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autism susceptibility gene 2 protein isoform 2 [Homo sapiens]

Protein Classification

fibrosin/Auts2 domain-containing protein( domain architecture ID 10633998)

fibrosin/Auts2 domain-containing protein similar to human fibrosin-1-like protein, also called autism susceptibility candidate 2 (AUTS2)-like protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Auts2 pfam15336
Autism susceptibility gene 2 protein; Auts2, or FBRSL2, Fibrosin-1-like protein 2, is a family ...
 621-833 2.02e-83

Autism susceptibility gene 2 protein; Auts2, or FBRSL2, Fibrosin-1-like protein 2, is a family of eukaryotic proteins associated both with a susceptibility to autism and with influencing the number of corpora lutea produced by breeding sows.


:

Pssm-ID: 464656  Cd Length: 217  Bit Score: 271.33  E-value: 2.02e-83
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452   621 KPGKWCAMHVHIAWQIYHHQQKVKkQMQSDPHKLDFGLKPEFLSRPPGPSLFGAIHHPHDLARPSTLFSAAGAAHPTGTP 700
Cdd:pfam15336    1 KPGKWCAMHVRIAWQIYHHQQKVK-QMQLDPHKLDVGLKLELLSRPPGPGVFGGFPYPHDLARPATLFSATGAAHPSATP 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452   701 FGPPPHHSNFLNPAAHLEPFNRPSTFTGLAAVGGNAFGGLGNPSVTPNSMFGHKDGPSVQNFSNPHEPWNRLHRTPPSFP 780
Cdd:pfam15336   80 FGPSPPHGSFLSPASHLDPFSRPSTFGGLGALSSGAFGGLGSPSLTANSVFGHKEGPPLQGFSSPHDPWNRLHRTPPSFP 159

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 187829452   781 TPPPWLKPGELERSASAAAHDRDRDVDKRD----SSVSKDDKERESVEK-RHSSHPSP 833
Cdd:pfam15336  160 TPPPWPKPGDAERSSSLESHERERDRERERekrdSSVIKDEKDRDSLDKnRHSSRSSP 217
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 298-456 2.89e-09

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 61.88  E-value: 2.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  298 PCPQVAQPIPQPQTEPQLRAPSPdpdlvqrteAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPP 377
Cdd:PHA03247 2882 PVRRLARPAVSRSTESFALPPDQ---------PERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGA 2952

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  378 VQAHPSAQSLSQPLSAYNSSSLSLNSLSSSRSSTPAKTQPAPPHISHHPS-----ASPFPLSLPNHSPLHSFTPTLQPPA 452
Cdd:PHA03247 2953 GEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSrvsswASSLALHEETDPPPVSLKQTLWPPD 3032


                  ....
gi 187829452  453 HSHH 456
Cdd:PHA03247 3033 DTED 3036
PTZ00121 super family cl31754
MAEBL; Provisional
 815-978 6.37e-04

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.36  E-value: 6.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  815 KDDKERESVEKRHSSHPSPAPVLPVNALGHTRSSTEQIRAHLNTEAREKDKPKERERDHSESRKDLAADEHKAKEGHL-P 893
Cdd:PTZ00121 1361 AAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKkA 1440

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  894 EKDGHGHEGRAAGEEAKQLARVPSPYVRTPVVESARPNSTSSREAEPRKgEPAYENPKKSSEVKVKEERKEDHDLPPEAP 973
Cdd:PTZ00121 1441 EEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAK-KKAEEAKKKADEAKKAAEAKKKADEAKKAE 1519


                  ....*
gi 187829452  974 QTHRA 978
Cdd:PTZ00121 1520 EAKKA 1524
 
Name Accession Description Interval E-value
Auts2 pfam15336
Autism susceptibility gene 2 protein; Auts2, or FBRSL2, Fibrosin-1-like protein 2, is a family ...
 621-833 2.02e-83

Autism susceptibility gene 2 protein; Auts2, or FBRSL2, Fibrosin-1-like protein 2, is a family of eukaryotic proteins associated both with a susceptibility to autism and with influencing the number of corpora lutea produced by breeding sows.


Pssm-ID: 464656  Cd Length: 217  Bit Score: 271.33  E-value: 2.02e-83
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452   621 KPGKWCAMHVHIAWQIYHHQQKVKkQMQSDPHKLDFGLKPEFLSRPPGPSLFGAIHHPHDLARPSTLFSAAGAAHPTGTP 700
Cdd:pfam15336    1 KPGKWCAMHVRIAWQIYHHQQKVK-QMQLDPHKLDVGLKLELLSRPPGPGVFGGFPYPHDLARPATLFSATGAAHPSATP 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452   701 FGPPPHHSNFLNPAAHLEPFNRPSTFTGLAAVGGNAFGGLGNPSVTPNSMFGHKDGPSVQNFSNPHEPWNRLHRTPPSFP 780
Cdd:pfam15336   80 FGPSPPHGSFLSPASHLDPFSRPSTFGGLGALSSGAFGGLGSPSLTANSVFGHKEGPPLQGFSSPHDPWNRLHRTPPSFP 159

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 187829452   781 TPPPWLKPGELERSASAAAHDRDRDVDKRD----SSVSKDDKERESVEK-RHSSHPSP 833
Cdd:pfam15336  160 TPPPWPKPGDAERSSSLESHERERDRERERekrdSSVIKDEKDRDSLDKnRHSSRSSP 217
PHA03247 PHA03247
large tegument protein UL36; Provisional
 298-456 2.89e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 61.88  E-value: 2.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  298 PCPQVAQPIPQPQTEPQLRAPSPdpdlvqrteAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPP 377
Cdd:PHA03247 2882 PVRRLARPAVSRSTESFALPPDQ---------PERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGA 2952

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  378 VQAHPSAQSLSQPLSAYNSSSLSLNSLSSSRSSTPAKTQPAPPHISHHPS-----ASPFPLSLPNHSPLHSFTPTLQPPA 452
Cdd:PHA03247 2953 GEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSrvsswASSLALHEETDPPPVSLKQTLWPPD 3032


                  ....
gi 187829452  453 HSHH 456
Cdd:PHA03247 3033 DTED 3036
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 300-438 3.19e-09

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 61.59  E-value: 3.19e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452   300 PQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPlstQPPQGPPEAQLQ-PAPQPQVQRPPRPQSPTQLLHQNLPPV 378
Cdd:pfam09770  219 AQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQ---HPGQGHPVTILQrPQSPQPDPAQPSIQPQAQQFHQQPPPV 295

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 187829452   379 QAHPSaQSLSQPlsaynssSLSLNSLSSSRSSTPAKTQPAPPHISHH-PSASPFPLSLPNH 438
Cdd:pfam09770  296 PVQPT-QILQNP-------NRLSAARVGYPQNPQPGVQPAPAHQAHRqQGSFGRQAPIITH 348
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 298-430 4.25e-05

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 47.88  E-value: 4.25e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452   298 PCPQVAQPIPQPQTEPQLRAPSPdpdlvqRTEAPPQP---PPLSTQPPQGPPEAQLQP---APQPQVQRPPR-----PQS 366
Cdd:TIGR01628  383 RQLPMGSPMGGAMGQPPYYGQGP------QQQFNGQPlgwPRMSMMPTPMGPGGPLRPnglAPMNAVRAPSRnaqnaAQK 456

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452   367 PTQLLHQNLPPVQAHPSAQSLSQPLSAYNSSSLSLNSLSSSRSSTPAKTQPAP-----PHI-SHHPSASP 430
Cdd:TIGR01628  457 PPMQPVMYPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQVLASATPQMQKQVLgerlfPLVeAIEPALAA 526
PTZ00121 PTZ00121
MAEBL; Provisional
 815-978 6.37e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.36  E-value: 6.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  815 KDDKERESVEKRHSSHPSPAPVLPVNALGHTRSSTEQIRAHLNTEAREKDKPKERERDHSESRKDLAADEHKAKEGHL-P 893
Cdd:PTZ00121 1361 AAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKkA 1440

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  894 EKDGHGHEGRAAGEEAKQLARVPSPYVRTPVVESARPNSTSSREAEPRKgEPAYENPKKSSEVKVKEERKEDHDLPPEAP 973
Cdd:PTZ00121 1441 EEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAK-KKAEEAKKKADEAKKAAEAKKKADEAKKAE 1519


                  ....*
gi 187829452  974 QTHRA 978
Cdd:PTZ00121 1520 EAKKA 1524
 
Name Accession Description Interval E-value
Auts2 pfam15336
Autism susceptibility gene 2 protein; Auts2, or FBRSL2, Fibrosin-1-like protein 2, is a family ...
 621-833 2.02e-83

Autism susceptibility gene 2 protein; Auts2, or FBRSL2, Fibrosin-1-like protein 2, is a family of eukaryotic proteins associated both with a susceptibility to autism and with influencing the number of corpora lutea produced by breeding sows.


Pssm-ID: 464656  Cd Length: 217  Bit Score: 271.33  E-value: 2.02e-83
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452   621 KPGKWCAMHVHIAWQIYHHQQKVKkQMQSDPHKLDFGLKPEFLSRPPGPSLFGAIHHPHDLARPSTLFSAAGAAHPTGTP 700
Cdd:pfam15336    1 KPGKWCAMHVRIAWQIYHHQQKVK-QMQLDPHKLDVGLKLELLSRPPGPGVFGGFPYPHDLARPATLFSATGAAHPSATP 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452   701 FGPPPHHSNFLNPAAHLEPFNRPSTFTGLAAVGGNAFGGLGNPSVTPNSMFGHKDGPSVQNFSNPHEPWNRLHRTPPSFP 780
Cdd:pfam15336   80 FGPSPPHGSFLSPASHLDPFSRPSTFGGLGALSSGAFGGLGSPSLTANSVFGHKEGPPLQGFSSPHDPWNRLHRTPPSFP 159

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 187829452   781 TPPPWLKPGELERSASAAAHDRDRDVDKRD----SSVSKDDKERESVEK-RHSSHPSP 833
Cdd:pfam15336  160 TPPPWPKPGDAERSSSLESHERERDRERERekrdSSVIKDEKDRDSLDKnRHSSRSSP 217
PHA03247 PHA03247
large tegument protein UL36; Provisional
 298-456 2.89e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 61.88  E-value: 2.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  298 PCPQVAQPIPQPQTEPQLRAPSPdpdlvqrteAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPP 377
Cdd:PHA03247 2882 PVRRLARPAVSRSTESFALPPDQ---------PERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGA 2952

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  378 VQAHPSAQSLSQPLSAYNSSSLSLNSLSSSRSSTPAKTQPAPPHISHHPS-----ASPFPLSLPNHSPLHSFTPTLQPPA 452
Cdd:PHA03247 2953 GEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSrvsswASSLALHEETDPPPVSLKQTLWPPD 3032


                  ....
gi 187829452  453 HSHH 456
Cdd:PHA03247 3033 DTED 3036
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 300-438 3.19e-09

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 61.59  E-value: 3.19e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452   300 PQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPlstQPPQGPPEAQLQ-PAPQPQVQRPPRPQSPTQLLHQNLPPV 378
Cdd:pfam09770  219 AQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQ---HPGQGHPVTILQrPQSPQPDPAQPSIQPQAQQFHQQPPPV 295

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 187829452   379 QAHPSaQSLSQPlsaynssSLSLNSLSSSRSSTPAKTQPAPPHISHH-PSASPFPLSLPNH 438
Cdd:pfam09770  296 PVQPT-QILQNP-------NRLSAARVGYPQNPQPGVQPAPAHQAHRqQGSFGRQAPIITH 348
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 298-457 3.84e-09

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 61.21  E-value: 3.84e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452   298 PCPQV-AQPIPQPQT----------EPQLRAPSPDPdlvqrteaPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQS 366
Cdd:pfam09770  175 PAPQPaAQPASLPAPsrkmmsleevEAAMRAQAKKP--------AQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQP 246

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452   367 PTQLLHQNLPPVQAHPSAQSLSQPLSAYNSSSLSLNSLSSSRSSTPAKTQPAPPHISHHPSASPFPLslpNHSPLHSFTP 446
Cdd:pfam09770  247 QQQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSAAR---VGYPQNPQPG 323

                          170
                   ....*....|.
gi 187829452   447 TLQPPAHSHHP 457
Cdd:pfam09770  324 VQPAPAHQAHR 334
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 257-455 6.81e-08

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 57.08  E-value: 6.81e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452   257 PEHDSQDAGPIVPKISGLERSQEKSQDCCKEPIFE--PVVLKDPCPQVAQPIPQPQTEPQLRAPSPDPdlvQRTEAPPQP 334
Cdd:pfam03154  134 PKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQILQtqPPVLQAQSGAASPPSPPPPGTTQAATAGPTP---SAPSVPPQG 210

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452   335 PPLSTQPPQGP-----PEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPPVQAhpSAQSLSQPlsaynssslslnSLSSSRS 409
Cdd:pfam03154  211 SPATSQPPNQTqstaaPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQV--SPQPLPQP------------SLHGQMP 276

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 187829452   410 STPAKTQPAPPHISHHPSASPFPLSLPNHSPLHSFTPTLQPPAHSH 455
Cdd:pfam03154  277 PMPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQ 322
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 287-392 8.61e-08

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 57.02  E-value: 8.61e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  287 EPIFEPVVLKDPCPQvAQPIPQPQTEpQLRAPSPDPdlvQRTEAPPQPPPlstqPPQGPPEAQLQPAPQPQVQRPPRPQS 366
Cdd:PRK10263  742 EPLFTPIVEPVQQPQ-QPVAPQQQYQ-QPQQPVAPQ---PQYQQPQQPVA----PQPQYQQPQQPVAPQPQYQQPQQPVA 812

                          90       100
                  ....*....|....*....|....*.
gi 187829452  367 PTQLLHQNLPPVQAHPSAQSLSQPLS 392
Cdd:PRK10263  813 PQPQYQQPQQPVAPQPQYQQPQQPVA 838
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 303-419 4.62e-07

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 54.10  E-value: 4.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  303 AQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLL--HQNLPPVQA 380
Cdd:PRK07994  362 AAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQraQGATKAKKS 441

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 187829452  381 HPSAQSLSQPLSAYNSSSLSLNSLSSSRSSTPAKTQPAP 419
Cdd:PRK07994  442 EPAAASRARPVNSALERLASVRPAPSALEKAPAKKEAYR 480
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 298-491 4.88e-07

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 54.27  E-value: 4.88e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452   298 PCPQVAQPIPQPQTEPQ--------LRAPSPDPDL----------VQRTEAPPQPPPLSTQPPQGPP-----------EA 348
Cdd:pfam09770  122 SLPQYQYASQQSQQPSKpvrtgyekYKEPEPIPDLqvdaslwgvaPKKAAAPAPAPQPAAQPASLPApsrkmmsleevEA 201

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452   349 QL-----QPAPQPQVQRPPRPQSPTQLLHQNLPPVQAHPSAQSLSQPLSAYNSsslslnslsssrsstPAKTQPAPPHIS 423
Cdd:pfam09770  202 AMraqakKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQ---------------QHPGQGHPVTIL 266

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 187829452   424 HHPSASPFPLSLPNHSPLHSFTPTLQPPAHSH------HPNMFAPPTALPPPPPLTsGSLQVAGHPAGSTYSEQ 491
Cdd:pfam09770  267 QRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQptqilqNPNRLSAARVGYPQNPQP-GVQPAPAHQAHRQQGSF 339
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 300-435 7.60e-07

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 53.56  E-value: 7.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  300 PQVAQPIPQP-QTEPQLRAPSPDPDlvqrteAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLLHqnlPPV 378
Cdd:PRK14951  366 PAAAAEAAAPaEKKTPARPEAAAPA------AAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAA---PAA 436

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 187829452  379 QAHPSAQSLSQPLSAYNSSSLSLNSLSSSRSSTPAKTQPAPPHISHHPSASPFPLSL 435
Cdd:PRK14951  437 APAAAPAAVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPTEE 493
PHA03247 PHA03247
large tegument protein UL36; Provisional
 271-598 9.03e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 9.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  271 ISGLErsQEKSQDCCKEPIFEPVVLKDPCPQVAQPIPQPqtepqlrAPSPDPDLVQRTEAPPQPPPLSTQP-----PQGP 345
Cdd:PHA03247 2537 IRGLE--ELASDDAGDPPPPLPPAAPPAAPDRSVPPPRP-------APRPSEPAVTSRARRPDAPPQSARPrapvdDRGD 2607

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  346 PEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPPVQAHPSAQSLSQPLSAYNSSSLSLNSLSSSRSSTPAKTqpAPPHISHH 425
Cdd:PHA03247 2608 PRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQAS--SPPQRPRR 2685

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  426 PSASPFPLSLPNHSPLHSFTPTLQPPAHSHHPNMFAPPTALPPPPPLTSGSLQVAGHPAGST----YSEQDILRQELnTR 501
Cdd:PHA03247 2686 RAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGpatpGGPARPARPPT-TA 2764

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  502 FLASQSADRGASLGPPPYLRTEFHQHQHQHQHTHQHTHQHTFTPFPHAIPPTAIMPTPAPPMFDKYPTKVDPfyrhslfh 581
Cdd:PHA03247 2765 GPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQP-------- 2836

                         330
                  ....*....|....*..
gi 187829452  582 SYPPAVSGIPPMIPPTG 598
Cdd:PHA03247 2837 TAPPPPPGPPPPSLPLG 2853
PHA03247 PHA03247
large tegument protein UL36; Provisional
 298-457 2.24e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.25  E-value: 2.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  298 PCPQVAQPIPQPQTEPQLRAPSPDPDLVQR---------TEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPT 368
Cdd:PHA03247 2836 PTAPPPPPGPPPPSLPLGGSVAPGGDVRRRppsrspaakPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPP 2915

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  369 QLLHQNLPPVQAHPSAQSLSQPLSaynsSSLSLNSLSSSRSSTPAKTQPAPPHISHHPSASPFPLSLPNHSPLHSFTPTL 448
Cdd:PHA03247 2916 PPQPQPQPPPPPQPQPPPPPPPRP----QPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPAS 2991


                  ....*....
gi 187829452  449 QPPAHSHHP 457
Cdd:PHA03247 2992 STPPLTGHS 3000
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 298-430 4.25e-05

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 47.88  E-value: 4.25e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452   298 PCPQVAQPIPQPQTEPQLRAPSPdpdlvqRTEAPPQP---PPLSTQPPQGPPEAQLQP---APQPQVQRPPR-----PQS 366
Cdd:TIGR01628  383 RQLPMGSPMGGAMGQPPYYGQGP------QQQFNGQPlgwPRMSMMPTPMGPGGPLRPnglAPMNAVRAPSRnaqnaAQK 456

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452   367 PTQLLHQNLPPVQAHPSAQSLSQPLSAYNSSSLSLNSLSSSRSSTPAKTQPAP-----PHI-SHHPSASP 430
Cdd:TIGR01628  457 PPMQPVMYPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQVLASATPQMQKQVLgerlfPLVeAIEPALAA 526
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 300-389 9.92e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 46.57  E-value: 9.92e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452   300 PQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQllhqnLPPVQ 379
Cdd:pfam09770  272 PQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQNPQPGVQPAPAHQAHRQQGSFGR-----QAPII 346

                           90
                   ....*....|
gi 187829452   380 AHPsaQSLSQ 389
Cdd:pfam09770  347 THP--QQLAQ 354
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 291-457 2.07e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 45.85  E-value: 2.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  291 EPVVLKDPCPQVAQPIPQPQTEPQlraPSPdpdlvqrteAPPQPPPLSTQPPQGPPeaqlqpaPQPQVQRPPRPQS-PTQ 369
Cdd:PRK10263  338 EPVTQTPPVASVDVPPAQPTVAWQ---PVP---------GPQTGEPVIAPAPEGYP-------QQSQYAQPAVQYNePLQ 398

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  370 LLHQNLPPVQAHPSAQSLSQPLSAynsssLSLNSLSSSRSSTPAKTQPAPPHISHHPSASPFPLSLPNHSPLHSFT-PTL 448
Cdd:PRK10263  399 QPVQPQQPYYAPAAEQPAQQPYYA-----PAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQqPAA 473


                  ....*....
gi 187829452  449 QPPAHSHHP 457
Cdd:PRK10263  474 QEPLYQQPQ 482
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 305-437 3.16e-04

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 45.10  E-value: 3.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  305 PIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPPVQAHPSA 384
Cdd:PHA03269   27 PIPELHTSAATQKPDPAPAPHQAASRAPDPAVAPTSAASRKPDLAQAPTPAASEKFDPAPAPHQAASRAPDPAVAPQLAA 106

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 187829452  385 QSLSQPLSAYNSSSLSLNSLSSSRSSTPAKTQPAPPHISHHPSASPFPLSLPN 437
Cdd:PHA03269  107 APKPDAAEAFTSAAQAHEAPADAGTSAASKKPDPAAHTQHSPPPFAYTRSMEH 159
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 288-444 5.24e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 44.69  E-value: 5.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  288 PIFEPVVLKDPCPQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSP 367
Cdd:PRK10263  352 PPAQPTVAWQPVPGPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQ 431

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  368 TQLLHQNLPPVQAHPSAQslSQPLSAYNSSSLSLNSLSSSRSSTPAKTQPAPPHISHHPSASPFPL---SLPNHSPLHSF 444
Cdd:PRK10263  432 PYYAPAPEQPVAGNAWQA--EEQQSTFAPQSTYQTEQTYQQPAAQEPLYQQPQPVEQQPVVEPEPVveeTKPARPPLYYF 509
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 288-378 5.71e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 44.03  E-value: 5.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  288 PIFEPVVLKDPCPQVAQPIPQPQTEPQLRAPSPDPdlvqrtEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSP 367
Cdd:PRK14950  364 PAPQPAKPTAAAPSPVRPTPAPSTRPKAAAAANIP------PKEPVRETATPPPVPPRPVAPPVPHTPESAPKLTRAAIP 437

                          90
                  ....*....|.
gi 187829452  368 TQLLHQNLPPV 378
Cdd:PRK14950  438 VDEKPKYTPPA 448
PTZ00121 PTZ00121
MAEBL; Provisional
 815-978 6.37e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.36  E-value: 6.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  815 KDDKERESVEKRHSSHPSPAPVLPVNALGHTRSSTEQIRAHLNTEAREKDKPKERERDHSESRKDLAADEHKAKEGHL-P 893
Cdd:PTZ00121 1361 AAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKkA 1440

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  894 EKDGHGHEGRAAGEEAKQLARVPSPYVRTPVVESARPNSTSSREAEPRKgEPAYENPKKSSEVKVKEERKEDHDLPPEAP 973
Cdd:PTZ00121 1441 EEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAK-KKAEEAKKKADEAKKAAEAKKKADEAKKAE 1519


                  ....*
gi 187829452  974 QTHRA 978
Cdd:PTZ00121 1520 EAKKA 1524
PRK10819 PRK10819
transport protein TonB; Provisional
 300-434 9.43e-04

transport protein TonB; Provisional


Pssm-ID: 236768 [Multi-domain]  Cd Length: 246  Bit Score: 42.36  E-value: 9.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  300 PQVAQPI------PQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQP-----PQGPPEAQLQPAPQPQVQRPPRPqspt 368
Cdd:PRK10819   42 PAPAQPIsvtmvaPADLEPPQAVQPPPEPVVEPEPEPEPIPEPPKEAPvvipkPEPKPKPKPKPKPKPVKKVEEQP---- 117

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 187829452  369 qllHQNLPPVQAHPsAQSLSQPLSAynssslslnslsssrSSTPAKTQPAPPHISHHPSASPFPLS 434
Cdd:PRK10819  118 ---KREVKPVEPRP-ASPFENTAPA---------------RPTSSTATAAASKPVTSVSSGPRALS 164
PRK11633 PRK11633
cell division protein DedD; Provisional
 297-367 9.68e-04

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 42.30  E-value: 9.68e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 187829452  297 DPCPQVAQPIP-QP----QTEPQLR---APSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSP 367
Cdd:PRK11633   54 DMMPAATQALPtQPpegaAEAVRAGdaaAPSLDPATVAPPNTPVEPEPAPVEPPKPKPVEKPKPKPKPQQKVEAPPAPK 132
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 300-369 1.03e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.44  E-value: 1.03e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  300 PQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQ 369
Cdd:PRK07764  430 QPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAA 499
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 307-428 1.32e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.05  E-value: 1.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  307 PQPQTEPQlRAPSPDPdlvqrTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLlHQNLPPVQAHPSAQS 386
Cdd:PRK07764  394 PAAAAPSA-AAAAPAA-----APAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAG-GAPSPPPAAAPSAQP 466

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 187829452  387 LSQPLSAYNSSSLSLNSLSSSRSSTPAKTQPAPPHISHHPSA 428
Cdd:PRK07764  467 APAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADD 508
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 261-367 1.84e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 42.76  E-value: 1.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  261 SQDAGPIVPKISGLERSQEKSQDCCKEPIFEPVVLKDPCPQVAQPIPQPQTEPQLRAPSPDpdlvQRTEAPPQPPPLSTQ 340
Cdd:PRK10263  384 SQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAG----NAWQAEEQQSTFAPQ 459

                          90       100
                  ....*....|....*....|....*..
gi 187829452  341 PPQGPPEAQLQPAPQPQVQRPPRPQSP 367
Cdd:PRK10263  460 STYQTEQTYQQPAAQEPLYQQPQPVEQ 486
PRK12757 PRK12757
cell division protein FtsN; Provisional
 302-369 1.88e-03

cell division protein FtsN; Provisional


Pssm-ID: 237191 [Multi-domain]  Cd Length: 256  Bit Score: 41.57  E-value: 1.88e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 187829452  302 VAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGP-PEAQLQPAPQPQVQRPPRPQSPTQ 369
Cdd:PRK12757  112 PQVPRSTVQIQQQAQQQQPPATTAQPQPVTPPRQTTAPVQPQTPaPVRTQPAAPVTQAVEAPKVEAEKE 180
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 298-385 1.89e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.67  E-value: 1.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  298 PCPQVAQPIPQPQTePQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQlQPAPQPQVQRPPRPQSPTQLLHQNLPP 377
Cdd:PRK07764  406 PAAAPAPAAAAPAA-AAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSP-PPAAAPSAQPAPAPAAAPEPTAAPAPA 483


                  ....*...
gi 187829452  378 VQAHPSAQ 385
Cdd:PRK07764  484 PPAAPAPA 491
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 289-420 3.12e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 41.72  E-value: 3.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  289 IFEPVVLKDPCPQVAQPipqpqtepqlRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPqvqrPPRPQSPt 368
Cdd:PRK14950  355 VIEALLVPVPAPQPAKP----------TAAAPSPVRPTPAPSTRPKAAAAANIPPKEPVRETATPPPV----PPRPVAP- 419

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 187829452  369 qllhqnlPPVQAHPSAQSLSqplsaynssslslnSLSSSRSSTPAKTQPAPP 420
Cdd:PRK14950  420 -------PVPHTPESAPKLT--------------RAAIPVDEKPKYTPPAPP 450
DUF6264 pfam19779
Family of unknown function (DUF6264); This family of putative integral membrane proteins is ...
 311-364 3.63e-03

Family of unknown function (DUF6264); This family of putative integral membrane proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 179 and 218 amino acids in length.


Pssm-ID: 466182  Cd Length: 182  Bit Score: 39.94  E-value: 3.63e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 187829452   311 TEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGP-------PEAQLQPAPQPQVQRPPRP 364
Cdd:pfam19779    9 PPGWQRAPIGDPAAAAAAAPPAAPAPAAPAPPAAPaappaapPPPGAPAPGAPAAARRARR 69
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 298-390 3.75e-03

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 40.61  E-value: 3.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  298 PCPQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAP-PQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLLHQNLP 376
Cdd:PHA02682  103 PAPAVTCPAPAPACPPATAPTCPPPAVCPAPARPaPACPPSTRQCPPAPPLPTPKPAPAAKPIFLHNQLPPPDYPAASCP 182

                          90
                  ....*....|....
gi 187829452  377 PVQAHPSAQSLSQP 390
Cdd:PHA02682  183 TIETAPAASPVLEP 196
PRK10819 PRK10819
transport protein TonB; Provisional
 286-390 3.97e-03

transport protein TonB; Provisional


Pssm-ID: 236768 [Multi-domain]  Cd Length: 246  Bit Score: 40.44  E-value: 3.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  286 KEPIFEPVVLKDPCPQVAQPIPQPQTEPQLRaPSPDPDLVQRTEAPPQPP--PLSTQPPQ-GPPEAQLQPAPQPQVQRPP 362
Cdd:PRK10819   72 VEPEPEPEPIPEPPKEAPVVIPKPEPKPKPK-PKPKPKPVKKVEEQPKREvkPVEPRPASpFENTAPARPTSSTATAAAS 150

                          90       100
                  ....*....|....*....|....*...
gi 187829452  363 RPQSptqllhqnlpPVQAHPSAQSLSQP 390
Cdd:PRK10819  151 KPVT----------SVSSGPRALSRNQP 168
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
298-446 5.40e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.01  E-value: 5.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  298 PCPQVAQPIPQPQTEPQLRAPSPDPDLVQrTEAPPQPPPlsTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPP 377
Cdd:PRK12323  428 PAPEALAAARQASARGPGGAPAPAPAPAA-APAAAARPA--AAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPP 504

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 187829452  378 VQAHPsaqSLSQPLSAYNSSSLSLNSLSSSRSSTPAKTQPAPPhishhPSASPFPLSLPNHSPLHSFTP 446
Cdd:PRK12323  505 EFASP---APAQPDAAPAGWVAESIPDPATADPDDAFETLAPA-----PAAAPAPRAAAATEPVVAPRP 565
PHA03378 PHA03378
EBNA-3B; Provisional
 305-392 5.81e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 41.21  E-value: 5.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  305 PIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPTQLLHQNLPPVQAHPSA 384
Cdd:PHA03378  743 RARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPRGAPTPQPPPQAGPTSMQLMPRAAPGQQGPTK 822


                  ....*...
gi 187829452  385 QSLSQPLS 392
Cdd:PHA03378  823 QILRQLLT 830
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 292-457 6.01e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.91  E-value: 6.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452   292 PVVLKDPCPQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQ-LQPAPQPQVQRPPRPQSPTQl 370
Cdd:pfam03154  286 PSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQpLPPAPLSMPHIKPPPTTPIP- 364

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452   371 lhqNLPPVQAHPSAQSLSQP--------------------LSAYNSSSLSLNSLSSSRSSTPAKTQPA-PPHISHHPSAS 429
Cdd:pfam03154  365 ---QLPNPQSHKHPPHLSGPspfqmnsnlppppalkplssLSTHHPPSAHPPPLQLMPQSQQLPPPPAqPPVLTQSQSLP 441

                          170       180
                   ....*....|....*....|....*...
gi 187829452   430 PFPLSLPNHSPLHSFTPTLQPPAHSHHP 457
Cdd:pfam03154  442 PPAASHPPTSGLHQVPSQSPFPQHPFVP 469
PRK14949 PRK14949
DNA polymerase III subunits gamma and tau; Provisional
 288-392 6.11e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237863 [Multi-domain]  Cd Length: 944  Bit Score: 40.86  E-value: 6.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  288 PIFEPVVLKDPCPQVAQPIPQPQTEPQLR-----APSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPP 362
Cdd:PRK14949  681 LATHQSVPEAALASGSAPAPPPVPDPYDRppweeAPEVASANDGPNNAAEGNLSESVEDASNSELQAVEQQATHQPQVQA 760

                          90       100       110
                  ....*....|....*....|....*....|....
gi 187829452  363 RPQSPTQ---LLHQNLPPVQAHPS-AQSLSQPLS 392
Cdd:PRK14949  761 EAQSPASttaLTQTSSEVQDTELNlVLLSSGSIT 794
PRK01297 PRK01297
ATP-dependent RNA helicase RhlB; Provisional
 308-370 6.84e-03

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 234938 [Multi-domain]  Cd Length: 475  Bit Score: 40.67  E-value: 6.84e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 187829452  308 QPQTEPQLRAPSPDPdlvqRTEAPPQPPPLSTQPPQGPPEAQLQPAP-QPQVQRPPRPQSPTQL 370
Cdd:PRK01297   16 QPAPAPPSPAAAPAP----PPPAKTAAPATKAAAPAAAAPRAEKPKKdKPRRERKPKPASLWKL 75
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 300-457 7.04e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.74  E-value: 7.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  300 PQVAQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPtqllhqnlPPVQ 379
Cdd:PRK07764  631 GAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAP--------AQPA 702

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 187829452  380 AHPSAQSLSQPLSAYNSSSLSLNSLSSSRSSTPAKTQPAPPHISHHPSASPFPLSLPNHSPLHSFTPTLQPPAHSHHP 457
Cdd:PRK07764  703 PAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPS 780
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
298-390 7.43e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 40.53  E-value: 7.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  298 PCPQVAQPIPQPQ-TEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQspTQLLHQNLP 376
Cdd:PRK14971  409 AQPSAPQSATQPAgTPPTVSVDPPAAVPVNPPSTAPQAVRPAQFKEEKKIPVSKVSSLGPSTLRPIQEK--AEQATGNIK 486

                          90
                  ....*....|....
gi 187829452  377 PVQAHPSAQSLSQP 390
Cdd:PRK14971  487 EAPTGTQKEIFTEE 500
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 303-393 7.67e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.74  E-value: 7.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  303 AQPIPQPQTEPQLRAPSPDPDLVQRTEAPPQPPPLSTQPPQGPPEAQLQPAPQPQVQRPPRPQSPtqllhqnlPPVQAHP 382
Cdd:PRK07764  429 PQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAA--------PAAPAAP 500

                          90
                  ....*....|.
gi 187829452  383 SAQSLSQPLSA 393
Cdd:PRK07764  501 AAPAGADDAAT 511
PRK10819 PRK10819
transport protein TonB; Provisional
 297-392 8.42e-03

transport protein TonB; Provisional


Pssm-ID: 236768 [Multi-domain]  Cd Length: 246  Bit Score: 39.28  E-value: 8.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  297 DPCPQVAQPIPQPQTEPQlraPSPDPdlvqrTEAPPQPPPLSTQPPQGPPEAQLQPAP--------------QPQVQRPP 362
Cdd:PRK10819   58 LEPPQAVQPPPEPVVEPE---PEPEP-----IPEPPKEAPVVIPKPEPKPKPKPKPKPkpvkkveeqpkrevKPVEPRPA 129

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 187829452  363 RP---QSPTQLLHQNLPPVQAHP--SAQSLSQPLS 392
Cdd:PRK10819  130 SPfenTAPARPTSSTATAAASKPvtSVSSGPRALS 164
PRK11633 PRK11633
cell division protein DedD; Provisional
 291-357 8.75e-03

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 39.22  E-value: 8.75e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 187829452  291 EPVVLKDPCPQVAQPIPQPQTEPQlrapsPDPDLVQRTEAPPQPpplstqPPQGPPEAQLQPAPQPQ 357
Cdd:PRK11633   93 PNTPVEPEPAPVEPPKPKPVEKPK-----PKPKPQQKVEAPPAP------KPEPKPVVEEKAAPTGK 148
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 319-442 9.42e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 40.45  E-value: 9.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 187829452  319 SPDPDLVQRTEAPPQPPPlSTQPPQGPpeaQLQPAPQPQVQRPPRPQSPTQLLHQNLPPVQAHPSAQSLSQPLSAYNSSS 398
Cdd:PRK10263  730 SPMKALLDDGPHEPLFTP-IVEPVQQP---QQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQ 805

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 187829452  399 LSLNSLSSSRSSTPAKTQPAPPHISHHPSASPFPlsLPNHSPLH 442
Cdd:PRK10263  806 QPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAP--QPQDTLLH 847
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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