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Conserved domains on  [gi|186530595|ref|NP_001119398|]
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Galactose oxidase/kelch repeat superfamily protein [Arabidopsis thaliana]

Protein Classification

F-box/kelch-repeat protein( domain architecture ID 17778853)

F-box/kelch-repeat protein may be a component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins

CATH:  1.20.1280.50|2.120.10.80
Gene Ontology:  GO:0006511|GO:0019005|GO:0005515|GO:0016567
PubMed:  10603472|31898225|11178263|31442578|24959344|10581972
SCOP:  4001927|3000448

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
112-243 2.27e-17

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 81.36  E-value: 2.27e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186530595 112 LAPIPNHHSHSSSiVAIGSNIYAIGGSIENAPSSKVSILDCRSHTWHEAPSMRMK-RNYPAANVVDGKIYVAGGLEEFDS 190
Cdd:COG3055    6 LPDLPTPRSEAAA-ALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPpRHHAAAVAQDGKLYVFGGFTGANP 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 186530595 191 SKWM----EVFDIKTQTWEFVLSPLAERFIYRSLVIEGEIYIFG--------DKVVTYKPKEDRW 243
Cdd:COG3055   85 SSTPlndvYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGgwddggnvAWVEVYDPATGTW 149
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 23-65 4.19e-15

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438923  Cd Length: 45  Bit Score: 68.75  E-value: 4.19e-15
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 186530595  23 PSLPDDLIVSILARVSRLYYPILSLVSKSSRTLVTSPELYKTR 65
Cdd:cd22152    3 PGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRVR 45
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
112-243 2.27e-17

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 81.36  E-value: 2.27e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186530595 112 LAPIPNHHSHSSSiVAIGSNIYAIGGSIENAPSSKVSILDCRSHTWHEAPSMRMK-RNYPAANVVDGKIYVAGGLEEFDS 190
Cdd:COG3055    6 LPDLPTPRSEAAA-ALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPpRHHAAAVAQDGKLYVFGGFTGANP 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 186530595 191 SKWM----EVFDIKTQTWEFVLSPLAERFIYRSLVIEGEIYIFG--------DKVVTYKPKEDRW 243
Cdd:COG3055   85 SSTPlndvYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGgwddggnvAWVEVYDPATGTW 149
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 23-65 4.19e-15

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438923  Cd Length: 45  Bit Score: 68.75  E-value: 4.19e-15
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 186530595  23 PSLPDDLIVSILARVSRLYYPILSLVSKSSRTLVTSPELYKTR 65
Cdd:cd22152    3 PGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRVR 45
PHA03098 PHA03098
kelch-like protein; Provisional
 124-286 7.11e-13

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 69.80  E-value: 7.11e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186530595 124 SIVAIGSNIYAIGGSIENAPSSKVSILDCRSHTWHEAPSMRMKRNYPAANVVDGKIYVAGGLEEFDSS-KWMEVFDIKTQ 202
Cdd:PHA03098 337 GVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGISKNDELlKTVECFSLNTN 416

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186530595 203 TWEfVLSPLAERFIYRSLVI-EGEIYIFG-----------DKVVTYKPKEDRWggvGEHQSMDLGLFFHSYCVIDNVLYC 270
Cdd:PHA03098 417 KWS-KGSPLPISHYGGCAIYhDGKIYVIGgisyidnikvyNIVESYNPVTNKW---TELSSLNFPRINASLCIFNNKIYV 492

                        170       180
                 ....*....|....*....|....*
gi 186530595 271 YrpGGIKW---------YESEKRSW 286
Cdd:PHA03098 493 V--GGDKYeyyineievYDDKTNTW 515
Kelch smart00612
Kelch domain;
132-177 6.44e-08

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 48.32  E-value: 6.44e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 186530595   132 IYAIGGSIENAPSSKVSILDCRSHTWHEAPSMRMKRNYPAANVVDG 177
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 167-207 9.33e-08

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 47.99  E-value: 9.33e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 186530595  167 RNYPAANVVDGKIYVAGGLEEFDSSKWMEVFDIKTQTWEFV 207
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKL 42
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 24-64 1.24e-06

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 44.84  E-value: 1.24e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 186530595   24 SLPDDLIVSILARVSRLYYPILSLVSKSSRTLVTSPELYKT 64
Cdd:pfam00646   3 DLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
FBOX smart00256
A Receptor for Ubiquitination Targets;
25-65 1.31e-03

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 36.26  E-value: 1.31e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 186530595    25 LPDDLIVSILARVSRLYYPILSLVSKSSRTLVTSPELYKTR 65
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
112-243 2.27e-17

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 81.36  E-value: 2.27e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186530595 112 LAPIPNHHSHSSSiVAIGSNIYAIGGSIENAPSSKVSILDCRSHTWHEAPSMRMK-RNYPAANVVDGKIYVAGGLEEFDS 190
Cdd:COG3055    6 LPDLPTPRSEAAA-ALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPpRHHAAAVAQDGKLYVFGGFTGANP 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 186530595 191 SKWM----EVFDIKTQTWEFVLSPLAERFIYRSLVIEGEIYIFG--------DKVVTYKPKEDRW 243
Cdd:COG3055   85 SSTPlndvYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGgwddggnvAWVEVYDPATGTW 149
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
112-230 2.29e-17

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 81.36  E-value: 2.29e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186530595 112 LAPIPNHHSHSSSIVAIGSNIYAIGGSIENAPSSKVS----ILDCRSHTWHEAPSMRMKRNYPAANVVDGKIYVAGGLEE 187
Cdd:COG3055   53 LAPLPGPPRHHAAAVAQDGKLYVFGGFTGANPSSTPLndvyVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDD 132

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 186530595 188 FDSSKWMEVFDIKTQTWEfVLSPLAERFIYRS--LVIEGEIYIFG 230
Cdd:COG3055  133 GGNVAWVEVYDPATGTWT-QLAPLPTPRDHLAaaVLPDGKILVIG 176
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 23-65 4.19e-15

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438923  Cd Length: 45  Bit Score: 68.75  E-value: 4.19e-15
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 186530595  23 PSLPDDLIVSILARVSRLYYPILSLVSKSSRTLVTSPELYKTR 65
Cdd:cd22152    3 PGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPELFRVR 45
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
112-230 4.06e-14

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 71.73  E-value: 4.06e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186530595 112 LAPIPNHHSHSSSIVAIGSNIYAIGGSIENAPSSkvsildcrshTWHEAPSMRMKRNYPAANVVDGKIYVAGGLEEFDSS 191
Cdd:COG3055  152 LAPLPTPRDHLAAAVLPDGKILVIGGRNGSGFSN----------TWTTLAPLPTARAGHAAAVLGGKILVFGGESGFSDE 221

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 186530595 192 kwMEVFDIKTQTWEfVLSPL-AERFIYRSLVIEGEIYIFG 230
Cdd:COG3055  222 --VEAYDPATNTWT-ALGELpTPRHGHAAVLTDGKVYVIG 258
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
156-289 3.28e-13

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 69.03  E-value: 3.28e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186530595 156 TWHEAPSMRMKRNYPAANVVDGKIYVAGGLEEFDSSKWMEVFDIKTQTWEFVLS-PLAERFIYRSLVIEGEIYIFG---- 230
Cdd:COG3055    2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPlPGPPRHHAAAVAQDGKLYVFGgftg 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 186530595 231 --------DKVVTYKPKEDRWGGVGehqSMDLGLFFHSYCVIDNVLY----CYRPGGIKW---YESEKRSWRKL 289
Cdd:COG3055   82 anpsstplNDVYVYDPATNTWTKLA---PMPTPRGGATALLLDGKIYvvggWDDGGNVAWvevYDPATGTWTQL 152
PHA03098 PHA03098
kelch-like protein; Provisional
 124-286 7.11e-13

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 69.80  E-value: 7.11e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186530595 124 SIVAIGSNIYAIGGSIENAPSSKVSILDCRSHTWHEAPSMRMKRNYPAANVVDGKIYVAGGLEEFDSS-KWMEVFDIKTQ 202
Cdd:PHA03098 337 GVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGISKNDELlKTVECFSLNTN 416

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186530595 203 TWEfVLSPLAERFIYRSLVI-EGEIYIFG-----------DKVVTYKPKEDRWggvGEHQSMDLGLFFHSYCVIDNVLYC 270
Cdd:PHA03098 417 KWS-KGSPLPISHYGGCAIYhDGKIYVIGgisyidnikvyNIVESYNPVTNKW---TELSSLNFPRINASLCIFNNKIYV 492

                        170       180
                 ....*....|....*....|....*
gi 186530595 271 YrpGGIKW---------YESEKRSW 286
Cdd:PHA03098 493 V--GGDKYeyyineievYDDKTNTW 515
PHA03098 PHA03098
kelch-like protein; Provisional
 84-269 1.39e-09

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 59.40  E-value: 1.39e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186530595  84 DPNPRWFTLYRKPNQNITEKTKNSSgfvlapipNHHSHSSSIVAIGSNIYAIGGSIENA-PSSKVSILDCRSHTWHEAPS 162
Cdd:PHA03098 257 ITMSIFTYNYITNYSPLSEINTIID--------IHYVYCFGSVVLNNVIYFIGGMNKNNlSVNSVVSYDTKTKSWNKVPE 328

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186530595 163 MRMKRNYPAANVVDGKIYVAGGLEEFDSSKWMEVFDIKTQTWEFVLSPLAERFIYRSLVIEGEIYIFG---------DKV 233
Cdd:PHA03098 329 LIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGgiskndellKTV 408

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 186530595 234 VTYKPKEDRWggvGEHQSMDLGLFFHSYCVIDNVLY 269
Cdd:PHA03098 409 ECFSLNTNKW---SKGSPLPISHYGGCAIYHDGKIY 441
PHA03098 PHA03098
kelch-like protein; Provisional
 112-211 6.30e-08

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 54.39  E-value: 6.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186530595 112 LAPIPNHHSHSSSIVAIGsNIYAIGG-SIENAPS--SKVSILDCRSHTWHEAPSMRMKRNYPAANVVDGKIYVAGGLEEF 188
Cdd:PHA03098 421 GSPLPISHYGGCAIYHDG-KIYVIGGiSYIDNIKvyNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYE 499

                         90       100
                 ....*....|....*....|...
gi 186530595 189 DSSKWMEVFDIKTQTWEFVLSPL 211
Cdd:PHA03098 500 YYINEIEVYDDKTNTWTLFCKFP 522
Kelch smart00612
Kelch domain;
132-177 6.44e-08

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 48.32  E-value: 6.44e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 186530595   132 IYAIGGSIENAPSSKVSILDCRSHTWHEAPSMRMKRNYPAANVVDG 177
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 167-207 9.33e-08

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 47.99  E-value: 9.33e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 186530595  167 RNYPAANVVDGKIYVAGGLEEFDSSKWMEVFDIKTQTWEFV 207
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKL 42
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 121-164 1.04e-07

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 47.99  E-value: 1.04e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 186530595  121 HSSSIVAIGSNIYAIGGSIENAPSSKVSILDCRSHTWHEAPSMR 164
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
112-184 4.01e-07

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 50.92  E-value: 4.01e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 186530595 112 LAPIPNHHSHSSSIVaIGSNIYAIGGsiENAPSSKVSILDCRSHTWHEAPSMRMKRNYPAANVVDGKIYVAGG 184
Cdd:COG3055  190 LAPLPTARAGHAAAV-LGGKILVFGG--ESGFSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGG 259
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 24-64 1.24e-06

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 44.84  E-value: 1.24e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 186530595   24 SLPDDLIVSILARVSRLYYPILSLVSKSSRTLVTSPELYKT 64
Cdd:pfam00646   3 DLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWKK 43
PLN02193 PLN02193
nitrile-specifier protein
 122-282 2.01e-04

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 43.02  E-value: 2.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186530595 122 SSSIVAIGSNIYAIGGS-IENAPSSK-VSILDCRSHTWHEAPSMRMKRNYPAANV----VDGKIYVAGGLEEFDSSKWME 195
Cdd:PLN02193 168 SHGIAQVGNKIYSFGGEfTPNQPIDKhLYVFDLETRTWSISPATGDVPHLSCLGVrmvsIGSTLYVFGGRDASRQYNGFY 247

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186530595 196 VFDIKTQTWEfVLSPLAERFIYRSL----VIEGEIYIFG-----DKVVT---YKPKEDRW-------------GGVGEH- 249
Cdd:PLN02193 248 SFDTTTNEWK-LLTPVEEGPTPRSFhsmaADEENVYVFGgvsatARLKTldsYNIVDKKWfhcstpgdsfsirGGAGLEv 326

                        170       180       190
                 ....*....|....*....|....*....|....
gi 186530595 250 -QSMDLGLFFHSYCVIDNVlYCYRPGGIKWYESE 282
Cdd:PLN02193 327 vQGKVWVVYGFNGCEVDDV-HYYDPVQDKWTQVE 359
PHA02713 PHA02713
hypothetical protein; Provisional
 48-238 2.73e-04

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 42.69  E-value: 2.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186530595  48 VSKSSRTLvtspeLYKTRSFfNRTESCLYVCLDFPPDPN--PRWFTL------YRKPNQNITEKTKNSSGF-VLAPIPNH 118
Cdd:PHA02713 220 LDKKSRLL-----LYSNKTI-NMYPSCIQFLLDNKQNRNiiPRQLCLvchdtkYNVCNPCILVYNINTMEYsVISTIPNH 293

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186530595 119 HSHSSSIVAIGSNIYAIGGSIENAPSSKVSILDCRSHTWHEAPSMRMKRNYPAANVVDGKIYVAGGLEEFDSSKWMEVFD 198
Cdd:PHA02713 294 IINYASAIVDNEIIIAGGYNFNNPSLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYT 373

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 186530595 199 IKTQTWEFVLSPLAERFIYRSLVIEGEIYIFGDKV--VTYKP 238
Cdd:PHA02713 374 MGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGRTehIDYTS 415
F-box_ScMDM30-like cd22143
F-box domain found in Saccharomyces cerevisiae mitochondrial distribution and morphology ...
 24-65 3.28e-04

F-box domain found in Saccharomyces cerevisiae mitochondrial distribution and morphology protein 30 (ScMDM30) and similar proteins; ScMDM30 is an F-box protein required for maintenance of fusion-competent mitochondria in yeast. It is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. ScMDM30 recognizes FZO1 and regulates the amount of FZO1. It acts as a regulatory factor for the mitochondrial fusion machinery and is required for mitochondrial DNA maintenance. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438915  Cd Length: 44  Bit Score: 37.98  E-value: 3.28e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 186530595  24 SLPDDLIVSILARVSRLYYPILSLVSKSSRTLVTsPELYKTR 65
Cdd:cd22143    4 SLPDEILSIIFSHLPQSDLYNLLFVNKHFYSLAL-PELWRSI 44
PLN02193 PLN02193
nitrile-specifier protein
 115-246 4.28e-04

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 42.25  E-value: 4.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186530595 115 IPNHHSHSSSIVAIGSNIYAIGGSIENAPSSKVSILDCRSHTW------HEAPSmrmKRNYPAANVVDGKIYVAGGLEEF 188
Cdd:PLN02193 214 VPHLSCLGVRMVSIGSTLYVFGGRDASRQYNGFYSFDTTTNEWklltpvEEGPT---PRSFHSMAADEENVYVFGGVSAT 290

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 186530595 189 DSSKWMEVFDIKTQTWeFVLSPLAERFIYRS----LVIEGEIYI-FG------DKVVTYKPKEDRWGGV 246
Cdd:PLN02193 291 ARLKTLDSYNIVDKKW-FHCSTPGDSFSIRGgaglEVVQGKVWVvYGfngcevDDVHYYDPVQDKWTQV 358
PHA02790 PHA02790
Kelch-like protein; Provisional
 121-243 6.82e-04

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 41.57  E-value: 6.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186530595 121 HSSSIVAIGSNIYAIGGSIENAPSSKVSILDCRSHTWHEAPSMRMKRNYPAANVVDGKIYVAGGLEEFDS-SKWMEvfdi 199
Cdd:PHA02790 263 HMCTSTHVGEVVYLIGGWMNNEIHNNAIAVNYISNNWIPIPPMNSPRLYASGVPANNKLYVVGGLPNPTSvERWFH---- 338

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 186530595 200 KTQTWEFVLSPLAERFIYRSLVIEGEIYIFG-----DKVVTY-KPKEDRW 243
Cdd:PHA02790 339 GDAAWVNMPSLLKPRCNPAVASINNVIYVIGghsetDTTTEYlLPNHDQW 388
Kelch_6 pfam13964
Kelch motif;
119-164 1.06e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 36.54  E-value: 1.06e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 186530595  119 HSHSSSIVAIGSNIYAIGG-SIENAPSSKVSILDCRSHTWHEAPSMR 164
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGyTNASPALNKLEVYNPLTKSWEELPPLP 47
Kelch_6 pfam13964
Kelch motif;
167-207 1.28e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 36.54  E-value: 1.28e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 186530595  167 RNYPAANVVDGKIYVAGGLE-EFDSSKWMEVFDIKTQTWEFV 207
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTnASPALNKLEVYNPLTKSWEEL 43
FBOX smart00256
A Receptor for Ubiquitination Targets;
25-65 1.31e-03

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 36.26  E-value: 1.31e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 186530595    25 LPDDLIVSILARVSRLYYPILSLVSKSSRTLVTSPELYKTR 65
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
PRK14131 PRK14131
N-acetylneuraminate epimerase;
166-230 4.89e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 38.46  E-value: 4.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186530595 166 KRNYPAANVVDGKIYVAGGLEEFDSSKWMEVF------DIKTQTWEFVL--SPlaerfiyRSLVI-------EGEIYIFG 230
Cdd:PRK14131  74 PREQAVAAFIDGKLYVFGGIGKTNSEGSPQVFddvykyDPKTNSWQKLDtrSP-------VGLAGhvavslhNGKAYITG 146
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 120-163 5.24e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 34.62  E-value: 5.24e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 186530595  120 SHSSSIVAIGSNIYAIGGSIENAP--SSKVSILDCRSHTWHEAPSM 163
Cdd:pfam07646   2 RYPHASSVPGGKLYVVGGSDGLGDlsSSDVLVYDPETNVWTEVPRL 47
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 23-60 5.67e-03

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 34.36  E-value: 5.67e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 186530595  23 PSLPDDLIVSILARVsrlyyPILSL-----VSKSSRTLVTSPE 60
Cdd:cd22157    1 SSLPDDLVEEILSRL-----PAKSLlrfrcVCKQWNSLISSPS 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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