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Conserved domains on  [gi|186500723|ref|NP_001118328|]
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F-box family protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN03215 super family cl31986
ascorbic acid mannose pathway regulator 1; Provisional
 467-700 2.17e-06

ascorbic acid mannose pathway regulator 1; Provisional


The actual alignment was detected with superfamily member PLN03215:

Pssm-ID: 178754 [Multi-domain]  Cd Length: 373  Bit Score: 50.72  E-value: 2.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186500723 467 MADWPLLPNDLLELIMGHLETSFEIFLFRSVCSSWRSVVPPLD-----HSRCLgIKTHDISFNVGFS----FNGRPtNEY 537
Cdd:PLN03215   1 MADWSTLPEELLHMIAGRLFSNVELKRFRSICRSWRSSVSGVGkknpfRTRPL-ILFNPINPSETLTddrsYISRP-GAF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186500723 538 ctLKKIPIYLVKFWTPFGDDYLLAEMRERNDGEPKlLLSPLSsngiKYGMGINKVLFNSLTSPIIPFGQYYEITYIEKRp 617
Cdd:PLN03215  79 --LSRAAFFRVTLSSSPSKGWLIKSDMDVNSGRFH-LLNPLS----RLPLRHSSESVDLLEFTVSEIREAYQVLDWAKR- 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186500723 618 SEYRFGFpyklewveitERVEFLKLDSEDSRDFAVLFAGRMCNlVMYRSRNMsWTQVVEhpEKYAYQDLVAFKGKFYAVD 697
Cdd:PLN03215 151 RETRPGY----------QRSALVKVKEGDNHRDGVLGIGRDGK-INYWDGNV-LKALKQ--MGYHFSDIIVHKGQTYALD 216


                 ...
gi 186500723 698 SSG 700
Cdd:PLN03215 217 SIG 219
 
Name Accession Description Interval E-value
PLN03215 PLN03215
ascorbic acid mannose pathway regulator 1; Provisional
 467-700 2.17e-06

ascorbic acid mannose pathway regulator 1; Provisional


Pssm-ID: 178754 [Multi-domain]  Cd Length: 373  Bit Score: 50.72  E-value: 2.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186500723 467 MADWPLLPNDLLELIMGHLETSFEIFLFRSVCSSWRSVVPPLD-----HSRCLgIKTHDISFNVGFS----FNGRPtNEY 537
Cdd:PLN03215   1 MADWSTLPEELLHMIAGRLFSNVELKRFRSICRSWRSSVSGVGkknpfRTRPL-ILFNPINPSETLTddrsYISRP-GAF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186500723 538 ctLKKIPIYLVKFWTPFGDDYLLAEMRERNDGEPKlLLSPLSsngiKYGMGINKVLFNSLTSPIIPFGQYYEITYIEKRp 617
Cdd:PLN03215  79 --LSRAAFFRVTLSSSPSKGWLIKSDMDVNSGRFH-LLNPLS----RLPLRHSSESVDLLEFTVSEIREAYQVLDWAKR- 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186500723 618 SEYRFGFpyklewveitERVEFLKLDSEDSRDFAVLFAGRMCNlVMYRSRNMsWTQVVEhpEKYAYQDLVAFKGKFYAVD 697
Cdd:PLN03215 151 RETRPGY----------QRSALVKVKEGDNHRDGVLGIGRDGK-INYWDGNV-LKALKQ--MGYHFSDIIVHKGQTYALD 216


                 ...
gi 186500723 698 SSG 700
Cdd:PLN03215 217 SIG 219
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 470-505 6.60e-05

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 40.60  E-value: 6.60e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 186500723  470 WPLLPNDLLELIMGHLETsFEIFLFRSVCSSWRSVV 505
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDP-KDLLRLSLVSKRWRSLV 35
FBOX smart00256
A Receptor for Ubiquitination Targets;
473-505 1.76e-04

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 39.34  E-value: 1.76e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 186500723   473 LPNDLLELIMGHLETsFEIFLFRSVCSSWRSVV 505
Cdd:smart00256   1 LPDEILEEILSKLDP-KDLLRLRKVSRKWRSLI 32
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 473-505 9.68e-03

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 34.34  E-value: 9.68e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 186500723 473 LPNDLLELIMGHLETSfEIFLFRSVCSSWRSVV 505
Cdd:cd09917    3 LPDEILLKILSYLDPR-DLLRLSLVCKRWRELA 34
 
Name Accession Description Interval E-value
PLN03215 PLN03215
ascorbic acid mannose pathway regulator 1; Provisional
 467-700 2.17e-06

ascorbic acid mannose pathway regulator 1; Provisional


Pssm-ID: 178754 [Multi-domain]  Cd Length: 373  Bit Score: 50.72  E-value: 2.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186500723 467 MADWPLLPNDLLELIMGHLETSFEIFLFRSVCSSWRSVVPPLD-----HSRCLgIKTHDISFNVGFS----FNGRPtNEY 537
Cdd:PLN03215   1 MADWSTLPEELLHMIAGRLFSNVELKRFRSICRSWRSSVSGVGkknpfRTRPL-ILFNPINPSETLTddrsYISRP-GAF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186500723 538 ctLKKIPIYLVKFWTPFGDDYLLAEMRERNDGEPKlLLSPLSsngiKYGMGINKVLFNSLTSPIIPFGQYYEITYIEKRp 617
Cdd:PLN03215  79 --LSRAAFFRVTLSSSPSKGWLIKSDMDVNSGRFH-LLNPLS----RLPLRHSSESVDLLEFTVSEIREAYQVLDWAKR- 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186500723 618 SEYRFGFpyklewveitERVEFLKLDSEDSRDFAVLFAGRMCNlVMYRSRNMsWTQVVEhpEKYAYQDLVAFKGKFYAVD 697
Cdd:PLN03215 151 RETRPGY----------QRSALVKVKEGDNHRDGVLGIGRDGK-INYWDGNV-LKALKQ--MGYHFSDIIVHKGQTYALD 216


                 ...
gi 186500723 698 SSG 700
Cdd:PLN03215 217 SIG 219
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 470-505 6.60e-05

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 40.60  E-value: 6.60e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 186500723  470 WPLLPNDLLELIMGHLETsFEIFLFRSVCSSWRSVV 505
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDP-KDLLRLSLVSKRWRSLV 35
FBOX smart00256
A Receptor for Ubiquitination Targets;
473-505 1.76e-04

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 39.34  E-value: 1.76e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 186500723   473 LPNDLLELIMGHLETsFEIFLFRSVCSSWRSVV 505
Cdd:smart00256   1 LPDEILEEILSKLDP-KDLLRLRKVSRKWRSLI 32
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 470-505 6.87e-03

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 35.15  E-value: 6.87e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 186500723  470 WPLLPNDLLELIMGHLETSfEIFLFRSVCSSWRSVV 505
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPK-DLLRLALVCRRWRELA 35
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 473-505 9.68e-03

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 34.34  E-value: 9.68e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 186500723 473 LPNDLLELIMGHLETSfEIFLFRSVCSSWRSVV 505
Cdd:cd09917    3 LPDEILLKILSYLDPR-DLLRLSLVCKRWRELA 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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