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Conserved domains on  [gi|186489959|ref|NP_001117460|]
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P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana]

Protein Classification

AAA family ATPase( domain architecture ID 14291541)

AAA family ATPase containing an AAA (ATPases Associated with various cellular Activities) domain, may function as an ATP-dependent endonuclease or the ATPase component of an ABC-type transporter

CATH:  3.40.50.300
Gene Ontology:  GO:0005524|GO:0016887
PubMed:  15037234|18208389|17897320|18466635|16072036|11916378|15037233
SCOP:  2000039

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 693-859 2.63e-83

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member cd19520:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 166  Bit Score: 265.83  E-value: 2.63e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 693 DIGALEDVKKALNELVILPMRRPELFARGNLLRPCKGILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKWFGDAE 772
Cdd:cd19520    1 DIGGLDEVITELKELVILPLQRPELFDNSRLLQPPKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 773 KLTKALFSFATKLAPVIIFVDEIDSLLGARgGSSEHEATRRMRNEFMAAWDGLRSKDSQRILILGATNRPFDLDDAVIRR 852
Cdd:cd19520   81 KLVAAVFSLASKLQPSIIFIDEIDSFLRQR-SSTDHEATAMMKAEFMSLWDGLSTDGNCRVIVMGATNRPQDLDEAILRR 159


                 ....*..
gi 186489959 853 LPRRIYV 859
Cdd:cd19520  160 MPKRFHI 166
AAA_lid_3 pfam17862
AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
 883-919 5.57e-09

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


:

Pssm-ID: 465537 [Multi-domain]  Cd Length: 45  Bit Score: 52.54  E-value: 5.57e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 186489959  883 DFQFEKLAKETEGYSGSDLKNLCIAAAYRPVQELLQE 919
Cdd:pfam17862   1 DVDLEELAERTEGFSGADLEALCREAALAALRRGLEA 37
McrB super family cl34253
5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB ...
 524-748 5.30e-05

5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms];


The actual alignment was detected with superfamily member COG1401:

Pssm-ID: 441011 [Multi-domain]  Cd Length: 477  Bit Score: 47.07  E-value: 5.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 524 KGLTEGFTGRGKSEENEIYKLFTNVMRLHPPKEEDTLRLFKKQLGEDRRIVISRSNINELLKALEEHELLCTDLYQVNTD 603
Cdd:COG1401    9 KFLIVGLRLKPLESEDAVRELGIRADDLRGAAELATRLAERLSEELLRADRAARATELVEELSAALEVVVLLLDLEKVEL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 604 GVILTKQKAEKAIGWAKNHYLASCPVPLVKGGRLSLPRESLEISIARLRKLEDNSLKPSQNLKNIAKDEYERNFVSAVVA 683
Cdd:COG1401   89 NEKLALSEAAVAIEELYELEADSEIEAVGLLLELAERSDALEALERARLLLELADLEERAALETEVLEALEAELEELLAA 168

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 186489959 684 PGEIGVKFEDIGALEDVKKALNELVILPMRRPELFARGN---------LLRPCKGILLFGPPGTGKTLLAKALA 748
Cdd:COG1401  169 PEDLSADALAAELSAAEELYSEDLESEDDYLKDLLREKFeetleaflaALKTKKNVILAGPPGTGKTYLARRLA 242
 
Name Accession Description Interval E-value
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 693-859 2.63e-83

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 265.83  E-value: 2.63e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 693 DIGALEDVKKALNELVILPMRRPELFARGNLLRPCKGILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKWFGDAE 772
Cdd:cd19520    1 DIGGLDEVITELKELVILPLQRPELFDNSRLLQPPKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 773 KLTKALFSFATKLAPVIIFVDEIDSLLGARgGSSEHEATRRMRNEFMAAWDGLRSKDSQRILILGATNRPFDLDDAVIRR 852
Cdd:cd19520   81 KLVAAVFSLASKLQPSIIFIDEIDSFLRQR-SSTDHEATAMMKAEFMSLWDGLSTDGNCRVIVMGATNRPQDLDEAILRR 159


                 ....*..
gi 186489959 853 LPRRIYV 859
Cdd:cd19520  160 MPKRFHI 166
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 668-950 1.63e-82

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 269.95  E-value: 1.63e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 668 IAKDEYERNFVSAVVAPGeigVKFEDIGALEDVKKALNELVILPMRRPELFAR-GnlLRPCKGILLFGPPGTGKTLLAKA 746
Cdd:COG1222   57 QKRLGTPRGTAVPAESPD---VTFDDIGGLDEQIEEIREAVELPLKNPELFRKyG--IEPPKGVLLYGPPGTGKTLLAKA 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 747 LATEAGANFISITGSTLTSKWFGDAEKLTKALFSFATKLAPVIIFVDEIDSLLGARGGSSEHEATRRMRNEFMAAWDGLR 826
Cdd:COG1222  132 VAGELGAPFIRVRGSELVSKYIGEGARNVREVFELAREKAPSIIFIDEIDAIAARRTDDGTSGEVQRTVNQLLAELDGFE 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 827 SKDSqrILILGATNRPFDLDDAVIR--RLPRRIYVDLPDAENRLKILKIFLTPENLESDFQFEKLAKETEGYSGSDLKNL 904
Cdd:COG1222  212 SRGD--VLIIAATNRPDLLDPALLRpgRFDRVIEVPLPDEEAREEILKIHLRDMPLADDVDLDKLAKLTEGFSGADLKAI 289

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 186489959 905 CIAAAYRPVQEllqeeqkgaraeaspGLRSLSLDDFIQSKAKVSPS 950
Cdd:COG1222  290 VTEAGMFAIRE---------------GRDTVTMEDLEKAIEKVKKK 320
cell_div_CdvC NF041006
cell division protein CdvC;
689-968 1.33e-68

cell division protein CdvC;


Pssm-ID: 468935 [Multi-domain]  Cd Length: 371  Bit Score: 233.86  E-value: 1.33e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 689 VKFEDIGALEDVKKALNELVILPMRRPELFARGnllRPcKGILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKWF 768
Cdd:NF041006 100 VTFSDIVGLEDVKEALKEAIVYPSKRPDLFPLG---WP-RGILLYGPPGCGKTMLAAAVANEIDSEFIHVDAASIMSKWL 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 769 GDAEKLTKALFSFATKLA-----PVIIFVDEIDSLLGARGGSSEHEAtrRMRNEFMAAWDGLRSKDSQ-RILILGATNRP 842
Cdd:NF041006 176 GEAEKNVAKIFKKAREKSkeegkPAIIFIDEIDALLGVYSSEVGGEV--RVRNQFLKEMDGLQDKSENyHVYVIGATNKP 253

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 843 FDLDDAVIRRLPRRIYVDLPDAENRLKILKIFLTPENLESDFQFEKLAKETEGYSGSDLKNLCIAAAYRPVQELLQeeqk 922
Cdd:NF041006 254 WRLDEPFLRRFQKRIYIPLPDREQRLELLKYYTSKIKLENDVDLDELAEMTEGYTASDIRDIVQAAHMRVVKEMFE---- 329

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 186489959 923 gaRAEASPglRSLSLDDFIQSKAKVSPSV------AYDAttmnelrkWNEQY 968
Cdd:NF041006 330 --KGLGEP--RPITMEDFKEVLKIRKPSVnqemlkAYEA--------WHEKF 369
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 689-969 4.93e-61

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 222.09  E-value: 4.93e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959  689 VKFEDIGALEDVKKALNELVILPMRRPELFARGNLlRPCKGILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKWF 768
Cdd:TIGR01243 450 VRWSDIGGLEEVKQELREAVEWPLKHPEIFEKMGI-RPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWV 528

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959  769 GDAEKLTKALFSFATKLAPVIIFVDEIDSLLGARGGSSEHEATRRMRNEFMAAWDGLrsKDSQRILILGATNRPFDLDDA 848
Cdd:TIGR01243 529 GESEKAIREIFRKARQAAPAIIFFDEIDAIAPARGARFDTSVTDRIVNQLLTEMDGI--QELSNVVVIAATNRPDILDPA 606

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959  849 VIR--RLPRRIYVDLPDAENRLKILKIFLTPENLESDFQFEKLAKETEGYSGSDLKNLCIAAAYRPVQELLQ---EEQKG 923
Cdd:TIGR01243 607 LLRpgRFDRLILVPPPDEEARKEIFKIHTRSMPLAEDVDLEELAEMTEGYTGADIEAVCREAAMAALRESIGspaKEKLE 686

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 186489959  924 ARAEASPGLRSLSLDDFIQSKAKVSPSVA-YDattMNELRKWNEQYG 969
Cdd:TIGR01243 687 VGEEEFLKDLKVEMRHFLEALKKVKPSVSkED---MLRYERLAKELK 730
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 688-910 1.65e-58

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 206.22  E-value: 1.65e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 688 GVKFEDIGALEDVKKALNELVILPMRRPELFAR-GnlLRPCKGILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSK 766
Cdd:PRK03992 127 NVTYEDIGGLEEQIREVREAVELPLKKPELFEEvG--IEPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQK 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 767 WFGDAEKLTKALFSFATKLAPVIIFVDEIDSlLGAR----GGSSEHEATRRMRnEFMAAWDGLRSKDsqRILILGATNRP 842
Cdd:PRK03992 205 FIGEGARLVRELFELAREKAPSIIFIDEIDA-IAAKrtdsGTSGDREVQRTLM-QLLAEMDGFDPRG--NVKIIAATNRI 280

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 843 FDLDDAVIR--RLPRRIYVDLPDAENRLKILKIFLTPENLESDFQFEKLAKETEGYSGSDLKNLCIAAAY 910
Cdd:PRK03992 281 DILDPAILRpgRFDRIIEVPLPDEEGRLEILKIHTRKMNLADDVDLEELAELTEGASGADLKAICTEAGM 350
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 730-861 3.73e-48

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 167.39  E-value: 3.73e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959  730 ILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKWFGDAEKLTKALFSFATKLAPVIIFVDEIDSLLGARgGSSEHE 809
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSR-GSGGDS 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 186489959  810 ATRRMRNEFMAAWDGLRSKDSqRILILGATNRPFDLDDAVIRRLPRRIYVDL 861
Cdd:pfam00004  80 ESRRVVNQLLTELDGFTSSNS-KVIVIAATNRPDKLDPALLGRFDRIIEFPL 130
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 728-863 2.38e-17

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 79.72  E-value: 2.38e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959   728 KGILLFGPPGTGKTLLAKALATEAGAN---FISITGSTLTS--------------KWFGDAEKLTKALFSFATKLAPVII 790
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALARELGPPgggVIYIDGEDILEevldqllliivggkKASGSGELRLRLALALARKLKPDVL 82

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 186489959   791 FVDEIDSLLGARggsseheaTRRMRNEFMAAWDGLRSKDSQRILILGATNRPFDLDDAVIR-RLPRRIYVDLPD 863
Cdd:smart00382  83 ILDEITSLLDAE--------QEALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRrRFDRRIVLLLIL 148
AAA_lid_3 pfam17862
AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
 883-919 5.57e-09

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


Pssm-ID: 465537 [Multi-domain]  Cd Length: 45  Bit Score: 52.54  E-value: 5.57e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 186489959  883 DFQFEKLAKETEGYSGSDLKNLCIAAAYRPVQELLQE 919
Cdd:pfam17862   1 DVDLEELAERTEGFSGADLEALCREAALAALRRGLEA 37
McrB COG1401
5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB ...
 524-748 5.30e-05

5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms];


Pssm-ID: 441011 [Multi-domain]  Cd Length: 477  Bit Score: 47.07  E-value: 5.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 524 KGLTEGFTGRGKSEENEIYKLFTNVMRLHPPKEEDTLRLFKKQLGEDRRIVISRSNINELLKALEEHELLCTDLYQVNTD 603
Cdd:COG1401    9 KFLIVGLRLKPLESEDAVRELGIRADDLRGAAELATRLAERLSEELLRADRAARATELVEELSAALEVVVLLLDLEKVEL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 604 GVILTKQKAEKAIGWAKNHYLASCPVPLVKGGRLSLPRESLEISIARLRKLEDNSLKPSQNLKNIAKDEYERNFVSAVVA 683
Cdd:COG1401   89 NEKLALSEAAVAIEELYELEADSEIEAVGLLLELAERSDALEALERARLLLELADLEERAALETEVLEALEAELEELLAA 168

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 186489959 684 PGEIGVKFEDIGALEDVKKALNELVILPMRRPELFARGN---------LLRPCKGILLFGPPGTGKTLLAKALA 748
Cdd:COG1401  169 PEDLSADALAAELSAAEELYSEDLESEDDYLKDLLREKFeetleaflaALKTKKNVILAGPPGTGKTYLARRLA 242
IS21_help_AAA NF038214
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was ...
 719-751 8.74e-04

IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was built to hit full-length AAA+ ATPases of IS21 family IS (insertion sequence) elements.


Pssm-ID: 439516  Cd Length: 232  Bit Score: 42.07  E-value: 8.74e-04
                         10        20        30
                 ....*....|....*....|....*....|...
gi 186489959 719 ARGNLLRPCKGILLFGPPGTGKTLLAKALATEA 751
Cdd:NF038214  82 ATLDFIERAENVLLLGPPGTGKTHLAIALGYAA 114
 
Name Accession Description Interval E-value
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 693-859 2.63e-83

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 265.83  E-value: 2.63e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 693 DIGALEDVKKALNELVILPMRRPELFARGNLLRPCKGILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKWFGDAE 772
Cdd:cd19520    1 DIGGLDEVITELKELVILPLQRPELFDNSRLLQPPKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 773 KLTKALFSFATKLAPVIIFVDEIDSLLGARgGSSEHEATRRMRNEFMAAWDGLRSKDSQRILILGATNRPFDLDDAVIRR 852
Cdd:cd19520   81 KLVAAVFSLASKLQPSIIFIDEIDSFLRQR-SSTDHEATAMMKAEFMSLWDGLSTDGNCRVIVMGATNRPQDLDEAILRR 159


                 ....*..
gi 186489959 853 LPRRIYV 859
Cdd:cd19520  160 MPKRFHI 166
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 668-950 1.63e-82

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 269.95  E-value: 1.63e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 668 IAKDEYERNFVSAVVAPGeigVKFEDIGALEDVKKALNELVILPMRRPELFAR-GnlLRPCKGILLFGPPGTGKTLLAKA 746
Cdd:COG1222   57 QKRLGTPRGTAVPAESPD---VTFDDIGGLDEQIEEIREAVELPLKNPELFRKyG--IEPPKGVLLYGPPGTGKTLLAKA 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 747 LATEAGANFISITGSTLTSKWFGDAEKLTKALFSFATKLAPVIIFVDEIDSLLGARGGSSEHEATRRMRNEFMAAWDGLR 826
Cdd:COG1222  132 VAGELGAPFIRVRGSELVSKYIGEGARNVREVFELAREKAPSIIFIDEIDAIAARRTDDGTSGEVQRTVNQLLAELDGFE 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 827 SKDSqrILILGATNRPFDLDDAVIR--RLPRRIYVDLPDAENRLKILKIFLTPENLESDFQFEKLAKETEGYSGSDLKNL 904
Cdd:COG1222  212 SRGD--VLIIAATNRPDLLDPALLRpgRFDRVIEVPLPDEEAREEILKIHLRDMPLADDVDLDKLAKLTEGFSGADLKAI 289

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 186489959 905 CIAAAYRPVQEllqeeqkgaraeaspGLRSLSLDDFIQSKAKVSPS 950
Cdd:COG1222  290 VTEAGMFAIRE---------------GRDTVTMEDLEKAIEKVKKK 320
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 694-859 7.67e-76

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 245.72  E-value: 7.67e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 694 IGALEDVKKALNELVILPMRRPELFArgNLLRPCKGILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKWFGDAEK 773
Cdd:cd19509    1 IAGLDDAKEALKEAVILPSLRPDLFP--GLRGPPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGESEK 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 774 LTKALFSFATKLAPVIIFVDEIDSLLGARgGSSEHEATRRMRNEFMAAWDGLRSKDSQRILILGATNRPFDLDDAVIRRL 853
Cdd:cd19509   79 IVRALFALARELQPSIIFIDEIDSLLSER-GSGEHEASRRVKTEFLVQMDGVLNKPEDRVLVLGATNRPWELDEAFLRRF 157


                 ....*.
gi 186489959 854 PRRIYV 859
Cdd:cd19509  158 EKRIYI 163
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 691-911 6.12e-74

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 249.44  E-value: 6.12e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 691 FEDIGALEDVKKALNELVILPMRRPELFARGNLlRPCKGILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKWFGD 770
Cdd:COG0464  156 LDDLGGLEEVKEELRELVALPLKRPELREEYGL-PPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSKYVGE 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 771 AEKLTKALFSFATKLAPVIIFVDEIDSLLGARGGSSEHeATRRMRNEFMAAWDGLRSkdsqRILILGATNRPFDLDDAVI 850
Cdd:COG0464  235 TEKNLREVFDKARGLAPCVLFIDEADALAGKRGEVGDG-VGRRVVNTLLTEMEELRS----DVVVIAATNRPDLLDPALL 309

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 186489959 851 RRLPRRIYVDLPDAENRLKILKIFLTPENLESDFQFEKLAKETEGYSGSDLKNLCIAAAYR 911
Cdd:COG0464  310 RRFDEIIFFPLPDAEERLEIFRIHLRKRPLDEDVDLEELAEATEGLSGADIRNVVRRAALQ 370
cell_div_CdvC NF041006
cell division protein CdvC;
689-968 1.33e-68

cell division protein CdvC;


Pssm-ID: 468935 [Multi-domain]  Cd Length: 371  Bit Score: 233.86  E-value: 1.33e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 689 VKFEDIGALEDVKKALNELVILPMRRPELFARGnllRPcKGILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKWF 768
Cdd:NF041006 100 VTFSDIVGLEDVKEALKEAIVYPSKRPDLFPLG---WP-RGILLYGPPGCGKTMLAAAVANEIDSEFIHVDAASIMSKWL 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 769 GDAEKLTKALFSFATKLA-----PVIIFVDEIDSLLGARGGSSEHEAtrRMRNEFMAAWDGLRSKDSQ-RILILGATNRP 842
Cdd:NF041006 176 GEAEKNVAKIFKKAREKSkeegkPAIIFIDEIDALLGVYSSEVGGEV--RVRNQFLKEMDGLQDKSENyHVYVIGATNKP 253

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 843 FDLDDAVIRRLPRRIYVDLPDAENRLKILKIFLTPENLESDFQFEKLAKETEGYSGSDLKNLCIAAAYRPVQELLQeeqk 922
Cdd:NF041006 254 WRLDEPFLRRFQKRIYIPLPDREQRLELLKYYTSKIKLENDVDLDELAEMTEGYTASDIRDIVQAAHMRVVKEMFE---- 329

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 186489959 923 gaRAEASPglRSLSLDDFIQSKAKVSPSV------AYDAttmnelrkWNEQY 968
Cdd:NF041006 330 --KGLGEP--RPITMEDFKEVLKIRKPSVnqemlkAYEA--------WHEKF 369
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 693-859 1.60e-63

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 212.02  E-value: 1.60e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 693 DIGALEDVKKALNELVILPMRRPELFArgNLLRPCKGILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKWFGDAE 772
Cdd:cd19524    1 DIAGQDLAKQALQEMVILPSLRPELFT--GLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 773 KLTKALFSFATKLAPVIIFVDEIDSLLGARgGSSEHEATRRMRNEFMAAWDGLRSKDSQRILILGATNRPFDLDDAVIRR 852
Cdd:cd19524   79 KLVRALFAVARELQPSIIFIDEVDSLLSER-SEGEHEASRRLKTEFLIEFDGVQSNGDDRVLVMGATNRPQELDDAVLRR 157


                 ....*..
gi 186489959 853 LPRRIYV 859
Cdd:cd19524  158 FTKRVYV 164
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 689-969 4.93e-61

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 222.09  E-value: 4.93e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959  689 VKFEDIGALEDVKKALNELVILPMRRPELFARGNLlRPCKGILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKWF 768
Cdd:TIGR01243 450 VRWSDIGGLEEVKQELREAVEWPLKHPEIFEKMGI-RPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWV 528

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959  769 GDAEKLTKALFSFATKLAPVIIFVDEIDSLLGARGGSSEHEATRRMRNEFMAAWDGLrsKDSQRILILGATNRPFDLDDA 848
Cdd:TIGR01243 529 GESEKAIREIFRKARQAAPAIIFFDEIDAIAPARGARFDTSVTDRIVNQLLTEMDGI--QELSNVVVIAATNRPDILDPA 606

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959  849 VIR--RLPRRIYVDLPDAENRLKILKIFLTPENLESDFQFEKLAKETEGYSGSDLKNLCIAAAYRPVQELLQ---EEQKG 923
Cdd:TIGR01243 607 LLRpgRFDRLILVPPPDEEARKEIFKIHTRSMPLAEDVDLEELAEMTEGYTGADIEAVCREAAMAALRESIGspaKEKLE 686

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 186489959  924 ARAEASPGLRSLSLDDFIQSKAKVSPSVA-YDattMNELRKWNEQYG 969
Cdd:TIGR01243 687 VGEEEFLKDLKVEMRHFLEALKKVKPSVSkED---MLRYERLAKELK 730
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 689-859 2.96e-60

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 203.68  E-value: 2.96e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 689 VKFEDIGALEDVKKALNELVILPMRRPELFArgNLLRPCKGILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKWF 768
Cdd:cd19525   19 INWADIAGLEFAKKTIKEIVVWPMLRPDIFT--GLRGPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWV 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 769 GDAEKLTKALFSFATKLAPVIIFVDEIDSLLGARgGSSEHEATRRMRNEFMAAWDGLRSKDSQRILILGATNRPFDLDDA 848
Cdd:cd19525   97 GEGEKMVRALFSVARCKQPAVIFIDEIDSLLSQR-GEGEHESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEA 175

                        170
                 ....*....|.
gi 186489959 849 VIRRLPRRIYV 859
Cdd:cd19525  176 ARRRLVKRLYI 186
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 688-910 1.65e-58

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 206.22  E-value: 1.65e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 688 GVKFEDIGALEDVKKALNELVILPMRRPELFAR-GnlLRPCKGILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSK 766
Cdd:PRK03992 127 NVTYEDIGGLEEQIREVREAVELPLKKPELFEEvG--IEPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQK 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 767 WFGDAEKLTKALFSFATKLAPVIIFVDEIDSlLGAR----GGSSEHEATRRMRnEFMAAWDGLRSKDsqRILILGATNRP 842
Cdd:PRK03992 205 FIGEGARLVRELFELAREKAPSIIFIDEIDA-IAAKrtdsGTSGDREVQRTLM-QLLAEMDGFDPRG--NVKIIAATNRI 280

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 843 FDLDDAVIR--RLPRRIYVDLPDAENRLKILKIFLTPENLESDFQFEKLAKETEGYSGSDLKNLCIAAAY 910
Cdd:PRK03992 281 DILDPAILRpgRFDRIIEVPLPDEEGRLEILKIHTRKMNLADDVDLEELAELTEGASGADLKAICTEAGM 350
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
 693-859 7.12e-58

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 196.36  E-value: 7.12e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 693 DIGALEDVKKALNELVILPMRRPELFArgNLLRPCKGILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKWFGDAE 772
Cdd:cd19522    1 DIADLEEAKKLLEEAVVLPMWMPEFFK--GIRRPWKGVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSKYRGESE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 773 KLTKALFSFATKLAPVIIFVDEIDSLLGARGGSSEHEATRRMRNEFMAAWDGL-----RSKDSQRILILGATNRPFDLDD 847
Cdd:cd19522   79 KLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSEEHEASRRVKSELLVQMDGVggaseNDDPSKMVMVLAATNFPWDIDE 158

                        170
                 ....*....|..
gi 186489959 848 AVIRRLPRRIYV 859
Cdd:cd19522  159 ALRRRLEKRIYI 170
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 689-859 3.84e-57

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 194.31  E-value: 3.84e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 689 VKFEDIGALEDVKKALNELVILPMRRPELFARGNllRPCKGILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKWF 768
Cdd:cd19521    4 VKWEDVAGLEGAKEALKEAVILPVKFPHLFTGNR--KPWSGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWM 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 769 GDAEKLTKALFSFATKLAPVIIFVDEIDSLLGARgGSSEHEATRRMRNEFMAAWDGLrSKDSQRILILGATNRPFDLDDA 848
Cdd:cd19521   82 GESEKLVKQLFAMARENKPSIIFIDEVDSLCGTR-GEGESEASRRIKTELLVQMNGV-GNDSQGVLVLGATNIPWQLDSA 159

                        170
                 ....*....|.
gi 186489959 849 VIRRLPRRIYV 859
Cdd:cd19521  160 IRRRFEKRIYI 170
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 700-859 3.20e-53

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 182.87  E-value: 3.20e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 700 VKKALNELVILPMRRPELFARGNLlRPCKGILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKWFGDAEKLTKALF 779
Cdd:cd19511    1 VKRELKEAVEWPLKHPDAFKRLGI-RPPKGVLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKYVGESERAVREIF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 780 SFATKLAPVIIFVDEIDSLLGARGGSSEHEATRRMRNEFMAAWDGLRSKdsQRILILGATNRPFDLDDAVIR--RLPRRI 857
Cdd:cd19511   80 QKARQAAPCIIFFDEIDSLAPRRGQSDSSGVTDRVVSQLLTELDGIESL--KGVVVIAATNRPDMIDPALLRpgRLDKLI 157


                 ..
gi 186489959 858 YV 859
Cdd:cd19511  158 YV 159
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 689-950 4.15e-53

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 198.98  E-value: 4.15e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959  689 VKFEDIGALEDVKKALNELVILPMRRPELFARGNLlRPCKGILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKWF 768
Cdd:TIGR01243 175 VTYEDIGGLKEAKEKIREMVELPMKHPELFEHLGI-EPPKGVLLYGPPGTGKTLLAKAVANEAGAYFISINGPEIMSKYY 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959  769 GDAEKLTKALFSFATKLAPVIIFVDEIDSLLGARGGSSeHEATRRMRNEFMAAWDGLrsKDSQRILILGATNRPFDLDDA 848
Cdd:TIGR01243 254 GESEERLREIFKEAEENAPSIIFIDEIDAIAPKREEVT-GEVEKRVVAQLLTLMDGL--KGRGRVIVIGATNRPDALDPA 330

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959  849 VIR--RLPRRIYVDLPDAENRLKILKIFLTPENLESDFQFEKLAKETEGYSGSDLKNLCIAAAYRPVQELLQEEQKGARA 926
Cdd:TIGR01243 331 LRRpgRFDREIVIRVPDKRARKEILKVHTRNMPLAEDVDLDKLAEVTHGFVGADLAALAKEAAMAALRRFIREGKINFEA 410

                         250       260
                  ....*....|....*....|....*...
gi 186489959  927 EASPG--LRSL--SLDDFIQSKAKVSPS 950
Cdd:TIGR01243 411 EEIPAevLKELkvTMKDFMEALKMVEPS 438
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 700-859 5.19e-49

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 170.75  E-value: 5.19e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 700 VKKALNELVILPMRRPELFARGNLlRPCKGILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKWFGDAEKLTKALF 779
Cdd:cd19529    1 VKQELKEAVEWPLLKPEVFKRLGI-RPPKGILLYGPPGTGKTLLAKAVATESNANFISVKGPELLSKWVGESEKAIREIF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 780 SFATKLAPVIIFVDEIDSLLGARGGSSEHEATRRMRNEFMAAWDGLrsKDSQRILILGATNRPFDLDDAVIR--RLPRRI 857
Cdd:cd19529   80 RKARQVAPCVIFFDEIDSIAPRRGTTGDSGVTERVVNQLLTELDGL--EEMNGVVVIAATNRPDIIDPALLRagRFDRLI 157


                 ..
gi 186489959 858 YV 859
Cdd:cd19529  158 YI 159
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 730-861 3.73e-48

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 167.39  E-value: 3.73e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959  730 ILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKWFGDAEKLTKALFSFATKLAPVIIFVDEIDSLLGARgGSSEHE 809
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSR-GSGGDS 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 186489959  810 ATRRMRNEFMAAWDGLRSKDSqRILILGATNRPFDLDDAVIRRLPRRIYVDL 861
Cdd:pfam00004  80 ESRRVVNQLLTELDGFTSSNS-KVIVIAATNRPDKLDPALLGRFDRIIEFPL 130
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 700-859 2.04e-47

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 166.30  E-value: 2.04e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 700 VKKALNELVILPMRRPELFARGNLLRpcKGILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKWFGDAEKLTKALF 779
Cdd:cd19481    1 LKASLREAVEAPRRGSRLRRYGLGLP--KGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVGESEKNLRKIF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 780 SFATKLAPVIIFVDEIDSLLGARGGSSEHEATRRMRNEFMAAWDGLRSKDsqRILILGATNRPFDLDDAVIR--RLPRRI 857
Cdd:cd19481   79 ERARRLAPCILFIDEIDAIGRKRDSSGESGELRRVLNQLLTELDGVNSRS--KVLVIAATNRPDLLDPALLRpgRFDEVI 156


                 ..
gi 186489959 858 YV 859
Cdd:cd19481  157 EF 158
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 693-859 7.36e-47

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 164.77  E-value: 7.36e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 693 DIGALEDVKKALNELVILPMRRPELFARGNLlRPCKGILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKWFGDAE 772
Cdd:cd19503    1 DIGGLDEQIASLKELIELPLKYPELFRALGL-KPPRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIVSKYLGESE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 773 KLTKALFSFATKLAPVIIFVDEIDSLLGARgGSSEHEATRRMRNEFMAAWDGLRSKDsqRILILGATNRPFDLDDAVIR- 851
Cdd:cd19503   80 KNLREIFEEARSHAPSIIFIDEIDALAPKR-EEDQREVERRVVAQLLTLMDGMSSRG--KVVVIAATNRPDAIDPALRRp 156


                 ....*....
gi 186489959 852 -RLPRRIYV 859
Cdd:cd19503  157 gRFDREVEI 165
ftsH CHL00176
cell division protein; Validated
 651-909 1.59e-46

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 177.55  E-value: 1.59e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 651 LRKLEDNSLKPSQNLKNIAKDEyernfvSAVVAPGEIGVKFEDIGALEDVKKALNELVILpMRRPELF-ARGNllRPCKG 729
Cdd:CHL00176 148 FQRSSNFKGGPGQNLMNFGKSK------ARFQMEADTGITFRDIAGIEEAKEEFEEVVSF-LKKPERFtAVGA--KIPKG 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 730 ILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKWFGDAEKLTKALFSFATKLAPVIIFVDEIDSL-----LGARGG 804
Cdd:CHL00176 219 VLLVGPPGTGKTLLAKAIAGEAEVPFFSISGSEFVEMFVGVGAARVRDLFKKAKENSPCIVFIDEIDAVgrqrgAGIGGG 298

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 805 SSEHEATrrmRNEFMAAWDGLrsKDSQRILILGATNRPFDLDDAVIR--RLPRRIYVDLPDAENRLKILKIFLTPENLES 882
Cdd:CHL00176 299 NDEREQT---LNQLLTEMDGF--KGNKGVIVIAATNRVDILDAALLRpgRFDRQITVSLPDREGRLDILKVHARNKKLSP 373

                        250       260
                 ....*....|....*....|....*..
gi 186489959 883 DFQFEKLAKETEGYSGSDLKNLCIAAA 909
Cdd:CHL00176 374 DVSLELIARRTPGFSGADLANLLNEAA 400
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
691-908 2.20e-46

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 166.60  E-value: 2.20e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 691 FEDIGALEDVKKALNELVILPMRRPELfaRGNLLRPCKGILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKWFGD 770
Cdd:COG1223    1 LDDVVGQEEAKKKLKLIIKELRRRENL--RKFGLWPPRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSLIGSYLGE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 771 AEKLTKALFSFAtKLAPVIIFVDEIDSLLGARGGSSEHEATRRMRNEFMAAWDGLRSKdsqrILILGATNRPFDLDDAVI 850
Cdd:COG1223   79 TARNLRKLFDFA-RRAPCVIFFDEFDAIAKDRGDQNDVGEVKRVVNALLQELDGLPSG----SVVIAATNHPELLDSALW 153

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 186489959 851 RRLPRRIYVDLPDAENRLKILKIFLTPENLESDFQFEKLAKETEGYSGSDLKNLCIAA 908
Cdd:COG1223  154 RRFDEVIEFPLPDKEERKEILELNLKKFPLPFELDLKKLAKKLEGLSGADIEKVLKTA 211
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 700-859 1.26e-45

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 161.14  E-value: 1.26e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 700 VKKALNELVILPMRRPELFARGNLlRPCKGILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKWFGDAEKLTKALF 779
Cdd:cd19528    1 VKRELQELVQYPVEHPDKFLKFGM-TPSKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 780 SFATKLAPVIIFVDEIDSLLGARGGSSEHE--ATRRMRNEFMAAWDGLRSKdsQRILILGATNRPFDLDDAVIR--RLPR 855
Cdd:cd19528   80 DKARAAAPCVLFFDELDSIAKARGGNIGDAggAADRVINQILTEMDGMNTK--KNVFIIGATNRPDIIDPAILRpgRLDQ 157


                 ....
gi 186489959 856 RIYV 859
Cdd:cd19528  158 LIYI 161
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 691-859 8.26e-43

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 153.65  E-value: 8.26e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 691 FEDIGALEDVKKALNELVILPMRRPELFARGNLLRPcKGILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKWFGD 770
Cdd:cd19502    2 YEDIGGLDEQIREIREVVELPLKHPELFEELGIEPP-KGVLLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVQKYIGE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 771 AEKLTKALFSFATKLAPVIIFVDEIDSLLGAR---GGSSEHEATRRMRnEFMAAWDGLRSKDsqRILILGATNRPFDLDD 847
Cdd:cd19502   81 GARLVRELFEMAREKAPSIIFIDEIDAIGAKRfdsGTGGDREVQRTML-ELLNQLDGFDPRG--NIKVIMATNRPDILDP 157

                        170
                 ....*....|....
gi 186489959 848 AVIR--RLPRRIYV 859
Cdd:cd19502  158 ALLRpgRFDRKIEF 171
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 689-859 3.96e-41

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 148.92  E-value: 3.96e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 689 VKFEDIGALEDVKKALNELVILpMRRPELFAR-GNllRPCKGILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKW 767
Cdd:cd19501    1 VTFKDVAGCEEAKEELKEVVEF-LKNPEKFTKlGA--KIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMF 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 768 FGDAEKLTKALFSFATKLAPVIIFVDEIDSLLGARG-----GSSEHEATrrmRNEFMAAWDGLRSKDSqrILILGATNRP 842
Cdd:cd19501   78 VGVGASRVRDLFEQAKKNAPCIVFIDEIDAVGRKRGaglggGHDEREQT---LNQLLVEMDGFESNTG--VIVIAATNRP 152

                        170
                 ....*....|....*....
gi 186489959 843 FDLDDAVIR--RLPRRIYV 859
Cdd:cd19501  153 DVLDPALLRpgRFDRQVYV 171
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 693-859 2.02e-40

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 146.57  E-value: 2.02e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 693 DIGALEDVKKALNELVILPMRRPELFArgNLLRPCKGILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKWFGDAE 772
Cdd:cd19523    1 DIAGLGALKAAIKEEVLWPLLRPDAFS--GLLRLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 773 KLTKALFSFATKLAPVIIFVDEIDSLLGARggSSEHEATRRMRNEFMAAWDGLRSKDSQRILILGATNRPFDLDDAVIRR 852
Cdd:cd19523   79 KILQASFLAARCRQPSVLFISDLDALLSSQ--DDEASPVGRLQVELLAQLDGVLGSGEDGVLVVCTTSKPEEIDESLRRY 156


                 ....*..
gi 186489959 853 LPRRIYV 859
Cdd:cd19523  157 FSKRLLV 163
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
681-909 1.08e-39

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 155.97  E-value: 1.08e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 681 VVAPGEIGVKFEDIGALEDVKKALNELV-ILpmRRPELFARgnlL--RPCKGILLFGPPGTGKTLLAKALATEAGANFIS 757
Cdd:COG0465  131 LYDEDKPKVTFDDVAGVDEAKEELQEIVdFL--KDPEKFTR---LgaKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFS 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 758 ITGSTLTSKWFG-------DaekltkaLFSFATKLAPVIIFVDEIDSLLGAR-----GGSSEHEATrrmRNEFMAAWDGL 825
Cdd:COG0465  206 ISGSDFVEMFVGvgasrvrD-------LFEQAKKNAPCIIFIDEIDAVGRQRgaglgGGHDEREQT---LNQLLVEMDGF 275

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 826 RSKDSqrILILGATNRPFDLDDAVIR--RLPRRIYVDLPDAENRLKILKIFLTPENLESDFQFEKLAKETEGYSGSDLKN 903
Cdd:COG0465  276 EGNEG--VIVIAATNRPDVLDPALLRpgRFDRQVVVDLPDVKGREAILKVHARKKPLAPDVDLEVIARRTPGFSGADLAN 353


                 ....*.
gi 186489959 904 LCIAAA 909
Cdd:COG0465  354 LVNEAA 359
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 693-857 3.43e-39

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 142.96  E-value: 3.43e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 693 DIGALEDVKKALNELVILPMRRPELFARGNLlRPCKGILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKWFGDAE 772
Cdd:cd19519    1 DIGGCRKQLAQIREMVELPLRHPELFKAIGI-KPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 773 KLTKALFSFATKLAPVIIFVDEIDSLLGARgGSSEHEATRRMRNEFMAAWDGLrsKDSQRILILGATNRPFDLDDAVIR- 851
Cdd:cd19519   80 SNLRKAFEEAEKNAPAIIFIDEIDAIAPKR-EKTHGEVERRIVSQLLTLMDGL--KQRAHVIVMAATNRPNSIDPALRRf 156


                 ....*..
gi 186489959 852 -RLPRRI 857
Cdd:cd19519  157 gRFDREI 163
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 697-859 4.06e-39

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 142.63  E-value: 4.06e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 697 LEDVKKALNELVILPMRRPELFARGNLLRPcKGILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKWFGDAEKLTK 776
Cdd:cd19530    1 LDHVREELTMSILRPIKRPDIYKALGIDLP-TGVLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKYVGESERAVR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 777 ALFSFATKLAPVIIFVDEIDSLLGARGGsSEHEATRRMRNEFMAAWDGLrsKDSQRILILGATNRPFDLDDAVIR--RLP 854
Cdd:cd19530   80 QVFQRARASAPCVIFFDEVDALVPKRGD-GGSWASERVVNQLLTEMDGL--EERSNVFVIAATNRPDIIDPAMLRpgRLD 156


                 ....*
gi 186489959 855 RRIYV 859
Cdd:cd19530  157 KTLYV 161
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 683-908 9.48e-39

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 150.31  E-value: 9.48e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 683 APGEigvKFEDIGALEDVKKALNELVILPMRRPELFARGNLlRPCKGILLFGPPGTGKTLLAKALATEAGANFISITGST 762
Cdd:PTZ00361 177 APLE---SYADIGGLEQQIQEIKEAVELPLTHPELYDDIGI-KPPKGVILYGPPGTGKTLLAKAVANETSATFLRVVGSE 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 763 LTSKWFGDAEKLTKALFSFATKLAPVIIFVDEIDSLLGAR-----GGssEHEATRRMRnEFMAAWDGLRSKDSQRILIlg 837
Cdd:PTZ00361 253 LIQKYLGDGPKLVRELFRVAEENAPSIVFIDEIDAIGTKRydatsGG--EKEIQRTML-ELLNQLDGFDSRGDVKVIM-- 327

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 186489959 838 ATNRPFDLDDAVIR--RLPRRIYVDLPDAENRLKILKIFLTPENLESDFQFEKLAKETEGYSGSDLKNLCIAA 908
Cdd:PTZ00361 328 ATNRIESLDPALIRpgRIDRKIEFPNPDEKTKRRIFEIHTSKMTLAEDVDLEEFIMAKDELSGADIKAICTEA 400
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
686-972 9.56e-39

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 154.04  E-value: 9.56e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 686 EIGVKFEDIGALEDVKKALNELVILpMRRPELFARGNLLRPcKGILLFGPPGTGKTLLAKALATEAGANFISITGSTLTS 765
Cdd:PRK10733 146 QIKTTFADVAGCDEAKEEVAELVEY-LREPSRFQKLGGKIP-KGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVE 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 766 KWFGDAEKLTKALFSFATKLAPVIIFVDEIDSL-----LGARGGSSEHEATrrmRNEFMAAWDGLRSKDSqrILILGATN 840
Cdd:PRK10733 224 MFVGVGASRVRDMFEQAKKAAPCIIFIDEIDAVgrqrgAGLGGGHDEREQT---LNQMLVEMDGFEGNEG--IIVIAATN 298

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 841 RPFDLDDAVIR--RLPRRIYVDLPDAENRLKILKIFLTPENLESDFQFEKLAKETEGYSGSDLKNLciaaayrpVQELLQ 918
Cdd:PRK10733 299 RPDVLDPALLRpgRFDRQVVVGLPDVRGREQILKVHMRRVPLAPDIDAAIIARGTPGFSGADLANL--------VNEAAL 370

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 186489959 919 EEQKGARaeaspglRSLSLDDFIQSKAKVSPSVAYDATTMNELRKWNEQYGEGG 972
Cdd:PRK10733 371 FAARGNK-------RVVSMVEFEKAKDKIMMGAERRSMVMTEAQKESTAYHEAG 417
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 700-859 2.38e-35

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 131.87  E-value: 2.38e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 700 VKKALNELVILPMRRPELFARGnlLRPCKGILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKWFGDAEKLTKALF 779
Cdd:cd19527    1 VKKEILDTIQLPLEHPELFSSG--LRKRSGILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYIGESEANVREVF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 780 SFATKLAPVIIFVDEIDSLLGARGGSSEHEATR-RMRNEFMAAWDGLrSKDSQRILILGATNRPFDLDDAVIR--RLPRR 856
Cdd:cd19527   79 QKARDAKPCVIFFDELDSLAPSRGNSGDSGGVMdRVVSQLLAELDGM-SSSGQDVFVIGATNRPDLLDPALLRpgRFDKL 157


                 ...
gi 186489959 857 IYV 859
Cdd:cd19527  158 LYL 160
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 693-855 2.39e-34

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 129.45  E-value: 2.39e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 693 DIGALEDVKKALNELVILPMRRPELFARGNLLrPCKGILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKWFGDAE 772
Cdd:cd19518    1 DIGGMDSTLKELCELLIHPILPPEYFQHLGVE-PPRGVLLHGPPGCGKTMLANAIAGELKVPFLKISATEIVSGVSGESE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 773 KLTKALFSFATKLAPVIIFVDEIDSLLGARGGSSEhEATRRMRNEFMAAWDGL--RSKDSQRILILGATNRPFDLDDAvI 850
Cdd:cd19518   80 EKIRELFDQAISNAPCIVFIDEIDAITPKRESAQR-EMERRIVSQLLTCMDELnnEKTAGGPVLVIGATNRPDSLDPA-L 157


                 ....*
gi 186489959 851 RRLPR 855
Cdd:cd19518  158 RRAGR 162
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 700-858 4.45e-34

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 128.32  E-value: 4.45e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 700 VKKALNELVILPMRRPELFARGNLlRPCKGILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKWFGDAEKLTKALF 779
Cdd:cd19526    1 VKKALEETIEWPSKYPKIFASSPL-RLRSGILLYGPPGCGKTLLASAIASECGLNFISVKGPELLNKYIGASEQNVRDLF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 780 SFATKLAPVIIFVDEIDSLLGARGGSSEHeATRRMRNEFMAAWDGLRSKDSqrILILGATNRPFDLDDAVIR--RLPRRI 857
Cdd:cd19526   80 SRAQSAKPCILFFDEFDSIAPKRGHDSTG-VTDRVVNQLLTQLDGVEGLDG--VYVLAATSRPDLIDPALLRpgRLDKLV 156


                 .
gi 186489959 858 Y 858
Cdd:cd19526  157 Y 157
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
 689-914 1.51e-32

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 131.04  E-value: 1.51e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 689 VKFEDIGALEDVKKALNELVILPMRRPELFARGNLlRPCKGILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKWF 768
Cdd:PTZ00454 142 VTYSDIGGLDIQKQEIREAVELPLTCPELYEQIGI-DPPRGVLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSEFVQKYL 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 769 GDAEKLTKALFSFATKLAPVIIFVDEIDSLLGAR-----GGSSEheaTRRMRNEFMAAWDGLRSKDSQRILIlgATNRPF 843
Cdd:PTZ00454 221 GEGPRMVRDVFRLARENAPSIIFIDEVDSIATKRfdaqtGADRE---VQRILLELLNQMDGFDQTTNVKVIM--ATNRAD 295

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 186489959 844 DLDDAVIR--RLPRRIYVDLPDAENRLKILKIFLTPENLESDFQFEKLAKETEGYSGSDLKNLCIAAAYRPVQ 914
Cdd:PTZ00454 296 TLDPALLRpgRLDRKIEFPLPDRRQKRLIFQTITSKMNLSEEVDLEDFVSRPEKISAADIAAICQEAGMQAVR 368
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
 693-858 4.36e-32

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 123.00  E-value: 4.36e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 693 DIGALEDVKKALNELVILPMRRPELFARGNLlRPCKGILLFGPPGTGKTLLAKALATEA--GANFISI---TGSTLTSKW 767
Cdd:cd19517    1 DIGGLSHYINQLKEMVFFPLLYPEVFAKFKI-TPPRGVLFHGPPGTGKTLMARALAAECskGGQKVSFfmrKGADCLSKW 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 768 FGDAEKLTKALFSFATKLAPVIIFVDEIDSLLGARggSSEHEATR-RMRNEFMAAWDGLRSKDsqRILILGATNRPFDLD 846
Cdd:cd19517   80 VGEAERQLRLLFEEAYRMQPSIIFFDEIDGLAPVR--SSKQEQIHaSIVSTLLALMDGLDNRG--QVVVIGATNRPDALD 155

                        170
                 ....*....|....
gi 186489959 847 DAVIR--RLPRRIY 858
Cdd:cd19517  156 PALRRpgRFDREFY 169
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 728-861 3.22e-21

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 91.05  E-value: 3.22e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 728 KGILLFGPPGTGKTLLAKALATEA---GANFISITGSTLTSKWFGDAEK---LTKALFSFATKLAPVIIFVDEIDSLlga 801
Cdd:cd00009   20 KNLLLYGPPGTGKTTLARAIANELfrpGAPFLYLNASDLLEGLVVAELFghfLVRLLFELAEKAKPGVLFIDEIDSL--- 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 186489959 802 rgGSSEHEATRRMRNEFMaawdgLRSKDSQRILILGATNRPF--DLDDAVIRRLPRRIYVDL 861
Cdd:cd00009   97 --SRGAQNALLRVLETLN-----DLRIDRENVRVIGATNRPLlgDLDRALYDRLDIRIVIPL 151
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 728-863 2.38e-17

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 79.72  E-value: 2.38e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959   728 KGILLFGPPGTGKTLLAKALATEAGAN---FISITGSTLTS--------------KWFGDAEKLTKALFSFATKLAPVII 790
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALARELGPPgggVIYIDGEDILEevldqllliivggkKASGSGELRLRLALALARKLKPDVL 82

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 186489959   791 FVDEIDSLLGARggsseheaTRRMRNEFMAAWDGLRSKDSQRILILGATNRPFDLDDAVIR-RLPRRIYVDLPD 863
Cdd:smart00382  83 ILDEITSLLDAE--------QEALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRrRFDRRIVLLLIL 148
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
 693-819 2.38e-16

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 77.41  E-value: 2.38e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 693 DIGALEDVKKALnelvilpMRRPELF---ARGNLLRPCKGILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKWFG 769
Cdd:cd19507    1 DVGGLDNLKDWL-------KKRKAAFskqASAYGLPTPKGLLLVGIQGTGKSLTAKAIAGVWQLPLLRLDMGRLFGGLVG 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 186489959 770 DAEKLTKALFSFATKLAPVIIFVDEIDSLLGARGGSSEHEATRRMRNEFM 819
Cdd:cd19507   74 ESESRLRQMIQTAEAIAPCVLWIDEIEKGFSNADSKGDSGTSSRVLGTFL 123
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
 727-859 5.37e-16

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 76.76  E-value: 5.37e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 727 CKGILLFGPPGTGKTLLAKALATEAGANFISI-TGSTLTSKWFGDAEKLTKALFSFAT----KLAP-----VIIFvDEID 796
Cdd:cd19504   35 VKGILLYGPPGTGKTLMARQIGKMLNAREPKIvNGPEILNKYVGESEANIRKLFADAEeeqrRLGAnsglhIIIF-DEID 113

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 186489959 797 SLLGARG----GSSEHEAtrrMRNEFMAAWDGLRSKDSqrILILGATNRPFDLDDAVIRrlPRRIYV 859
Cdd:cd19504  114 AICKQRGsmagSTGVHDT---VVNQLLSKIDGVEQLNN--ILVIGMTNRKDLIDEALLR--PGRLEV 173
ycf46 CHL00195
Ycf46; Provisional
 689-910 4.23e-14

Ycf46; Provisional


Pssm-ID: 177094 [Multi-domain]  Cd Length: 489  Bit Score: 75.83  E-value: 4.23e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 689 VKFEDIGALEDVKKALNelvilpmRRPELFARG----NLLRPcKGILLFGPPGTGKTLLAKALATEAGANFISITGSTLT 764
Cdd:CHL00195 225 EKISDIGGLDNLKDWLK-------KRSTSFSKQasnyGLPTP-RGLLLVGIQGTGKSLTAKAIANDWQLPLLRLDVGKLF 296

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 765 SKWFGDAEKLTKALFSFATKLAPVIIFVDEIDSLLGARGGSSEHEATRRMRNEFmAAWdgLRSKDSQRILILGATNrpFD 844
Cdd:CHL00195 297 GGIVGESESRMRQMIRIAEALSPCILWIDEIDKAFSNSESKGDSGTTNRVLATF-ITW--LSEKKSPVFVVATANN--ID 371

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 186489959 845 -LDDAVIR--RLPRRIYVDLPDAENRLKILKIFLT---PENLESdFQFEKLAKETEGYSGSDLKNLCIAAAY 910
Cdd:CHL00195 372 lLPLEILRkgRFDEIFFLDLPSLEEREKIFKIHLQkfrPKSWKK-YDIKKLSKLSNKFSGAEIEQSIIEAMY 442
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
 726-853 6.75e-14

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 69.86  E-value: 6.75e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 726 PCKGILLFGPPGTGKTLLAKALATEAGANFISITGstltskwfGD-----AEKLTK--ALFSFA-TKLAPVIIFVDEIDS 797
Cdd:cd19512   21 LYRNILFYGPPGTGKTLFAKKLALHSGMDYAIMTG--------GDvapmgREGVTAihKVFDWAnTSRRGLLLFVDEADA 92

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 186489959 798 LLGARGGSSEHEATRRMRNEFMaawdgLRSKD-SQRILILGATNRPFDLDDAVIRRL 853
Cdd:cd19512   93 FLRKRSTEKISEDLRAALNAFL-----YRTGEqSNKFMLVLASNQPEQFDWAINDRI 144
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
 722-859 5.48e-13

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 68.63  E-value: 5.48e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 722 NLLRPCKGILLFGPPGTGKTLLAKALA---------TEAGANFISITGSTLTSKWFGDAEKLTKALFSFATKL-----AP 787
Cdd:cd19508   47 NLITWNRLVLLHGPPGTGKTSLCKALAqklsirlssRYRYGQLIEINSHSLFSKWFSESGKLVTKMFQKIQELiddkdAL 126

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 186489959 788 VIIFVDEIDSLLGARGG-SSEHEATRRMR--NEFMAAWDGLRSKDSqrILILGATNRPFDLDDAVIRRLPRRIYV 859
Cdd:cd19508  127 VFVLIDEVESLAAARSAsSSGTEPSDAIRvvNAVLTQIDRIKRYHN--NVILLTSNLLEKIDVAFVDRADIKQYI 199
RecA-like_IQCA1 cd19506
ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein ...
 699-846 2.49e-12

ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein regulatory complex subunit 11, DRC11 and IQCA) is an ATPase subunit of the nexin-dynein regulatory complex (N-DRC). The 9 + 2 axoneme of most motile cilia and flagella consists of nine outer doublet microtubules arranged in a ring surrounding a central pair of two singlet microtubules. The N-DRC complex maintains alignment between outer doublet microtubules and limits microtubule sliding in motile axonemes. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410914 [Multi-domain]  Cd Length: 160  Bit Score: 66.01  E-value: 2.49e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 699 DVKKALNELVILPMRRPELFARGNLLrpcKGILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKWFGDA--EKLTK 776
Cdd:cd19506    1 DVRQLLTLYGILPLGSQAVHEKAPLV---KSLLLAGPSGVGKKMLVHAICTETGANLFNLSPSNIAGKYPGKNglQMMLH 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 186489959 777 ALFSFATKLAPVIIFVDEIDSLLGARGGSSEHEAT-RRMRNEFMAAWDGLRSKDsqRILILGATNRPFDLD 846
Cdd:cd19506   78 LVLKVARQLQPSVIWIGDAEKTFYKKVPKTEKQLDpKRLKKDLPKILKSLKPED--RVLIVGTTSRPFEAD 146
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 728-859 2.17e-09

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 56.98  E-value: 2.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 728 KGILLFGPPGTGKTLLAKALATEAGANF--ISITGSTLTSkwfgdaeKLTKALFSFATKLApvIIFVDEIDSLLGARggs 805
Cdd:cd19510   24 RGYLLYGPPGTGKSSFIAALAGELDYDIcdLNLSEVVLTD-------DRLNHLLNTAPKQS--IILLEDIDAAFESR--- 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 186489959 806 sEHEATRRMRNEFMA---------AWDGLRSKDsQRILILgATNRPFDLDDAVIR--RLPRRIYV 859
Cdd:cd19510   92 -EHNKKNPSAYGGLSrvtfsgllnALDGVASSE-ERIVFM-TTNHIERLDPALIRpgRVDMKIYM 153
AAA_lid_3 pfam17862
AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
 883-919 5.57e-09

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


Pssm-ID: 465537 [Multi-domain]  Cd Length: 45  Bit Score: 52.54  E-value: 5.57e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 186489959  883 DFQFEKLAKETEGYSGSDLKNLCIAAAYRPVQELLQE 919
Cdd:pfam17862   1 DVDLEELAERTEGFSGADLEALCREAALAALRRGLEA 37
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 717-872 2.66e-08

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 56.33  E-value: 2.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 717 LFARGNLLrpckgilLFGPPGTGKTLLAKALATEAGANFI-----------SITGSTLTSKWFGDaekltkalFSFatKL 785
Cdd:COG0714   28 LLAGGHLL-------LEGVPGVGKTTLAKALARALGLPFIriqftpdllpsDILGTYIYDQQTGE--------FEF--RP 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 786 APV---IIFVDEID--------SLLGARggsSEHE-----ATRRMRNEFMaawdglrskdsqrilILGATNRP-----FD 844
Cdd:COG0714   91 GPLfanVLLADEINrappktqsALLEAM---EERQvtipgGTYKLPEPFL---------------VIATQNPIeqegtYP 152

                        170       180
                 ....*....|....*....|....*...
gi 186489959 845 LDDAVIRRLPRRIYVDLPDAENRLKILK 872
Cdd:COG0714  153 LPEAQLDRFLLKLYIGYPDAEEEREILR 180
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 730-799 7.41e-08

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 55.86  E-value: 7.41e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 186489959 730 ILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKwfgDAEKLTKALFSFATKLAPVIIFVDEI--------DSLL 799
Cdd:PRK13342  39 MILWGPPGTGKTTLARIIAGATDAPFEALSAVTSGVK---DLREVIEEARQRRSAGRRTILFIDEIhrfnkaqqDALL 113
RecA-like_HslU cd19498
ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease ...
 728-812 4.52e-07

ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease HslVU. In HslVU, HslU ATPase serves to unfold and translocate protein substrate, and the HslV protease degrades the unfolded proteins. This RecA-like_HslU subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410906 [Multi-domain]  Cd Length: 183  Bit Score: 51.23  E-value: 4.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 728 KGILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKWFgdaekLTKALFSFATKLAPVIIFVDEIDSlLGARGGSSE 807
Cdd:cd19498   47 KNILMIGPTGVGKTEIARRLAKLAGAPFIKVEATKFTEVGY-----VGRDVESIIRDLVEGIVFIDEIDK-IAKRGGSSG 120


                 ....*
gi 186489959 808 HEATR 812
Cdd:cd19498  121 PDVSR 125
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
 730-801 9.77e-07

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 52.37  E-value: 9.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 730 ILLFGPPGTGKTLLAKALATEAGANFISItgSTLTSkwfGDAE-----KLTKALFSFATKlapVIIFVDEI--------D 796
Cdd:COG2256   52 MILWGPPGTGKTTLARLIANATDAEFVAL--SAVTS---GVKDireviEEARERRAYGRR---TILFVDEIhrfnkaqqD 123


                 ....*
gi 186489959 797 SLLGA 801
Cdd:COG2256  124 ALLPH 128
TIP49 COG1224
DNA helicase TIP49, TBP-interacting protein [Transcription];
728-778 1.10e-06

DNA helicase TIP49, TBP-interacting protein [Transcription];


Pssm-ID: 440837 [Multi-domain]  Cd Length: 452  Bit Score: 52.28  E-value: 1.10e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 186489959 728 KGILLFGPPGTGKTLLAKALATEAGAN--FISITGSTLTSKWFGDAEKLTKAL 778
Cdd:COG1224   65 KGILIVGPPGTGKTALAVAIARELGEDtpFVAISGSEIYSAELKKTEFLMQAL 117
RecA-like_superfamily cd01120
RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 ...
 730-824 2.22e-06

RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410865 [Multi-domain]  Cd Length: 119  Bit Score: 47.50  E-value: 2.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 730 ILLFGPPGTGKTLLAKALATEAGAN-----FISItgstltskwfgdAEKLTKALFSFATKLAPVIIFVDEIDSLLGARGG 804
Cdd:cd01120    1 ILITGPPGSGKTTLLLQFAEQALLSdepviFISF------------LDTILEAIEDLIEEKKLDIIIIDSLSSLARASQG 68

                         90       100
                 ....*....|....*....|
gi 186489959 805 SSEHEATRRMRNEFMAAWDG 824
Cdd:cd01120   69 DRSSELLEDLAKLLRAARNT 88
RuvB_N pfam05496
Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the ...
 730-795 3.26e-06

Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the RuvABC revolvasome which catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalyzed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein. This family contains the N-terminal region of the protein.


Pssm-ID: 398900 [Multi-domain]  Cd Length: 159  Bit Score: 47.88  E-value: 3.26e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 186489959  730 ILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKwfGDaekltkaLFSFATKLAPV-IIFVDEI 795
Cdd:pfam05496  36 VLLYGPPGLGKTTLANIIANEMGVNIRITSGPAIERP--GD-------LAAILTNLEPGdVLFIDEI 93
ruvB PRK00080
Holliday junction branch migration DNA helicase RuvB;
730-798 6.25e-06

Holliday junction branch migration DNA helicase RuvB;


Pssm-ID: 234619 [Multi-domain]  Cd Length: 328  Bit Score: 49.36  E-value: 6.25e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 730 ILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKwfGDaekltkaLFSFATKLAPV-IIFVDEIDSL 798
Cdd:PRK00080  54 VLLYGPPGLGKTTLANIIANEMGVNIRITSGPALEKP--GD-------LAAILTNLEEGdVLFIDEIHRL 114
TIP49 pfam06068
TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and ...
 728-778 1.05e-05

TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the pfam00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases.


Pssm-ID: 399217 [Multi-domain]  Cd Length: 347  Bit Score: 48.84  E-value: 1.05e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 186489959  728 KGILLFGPPGTGKTLLAKALATEAGAN--FISITGSTLTSKWFGDAEKLTKAL 778
Cdd:pfam06068  51 RAVLIAGPPGTGKTALAIAISKELGEDtpFTSISGSEVYSLEMKKTEALTQAF 103
RecA-like_Ycf2 cd19505
ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; ...
 724-859 2.79e-05

ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; however, its function remains unclear. The gene encoding YCF2 is the largest known plastid gene in angiosperms and has been used to predict phylogenetic relationships. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410913 [Multi-domain]  Cd Length: 161  Bit Score: 45.44  E-value: 2.79e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 724 LRPCKGILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKWFG---------------DAEKLTkALFSFATKLAPV 788
Cdd:cd19505    9 LSPSKGILLIGSIETGRSYLIKSLAANSYVPLIRISLNKLLYNKPDfgnddwidgmlilkeSLHRLN-LQFELAKAMSPC 87

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 186489959 789 IIFVDEIDSL----LGARGGSSEHEATRRMRNEFMaawDGLRSKDSQRILILGATNRPFDLDDAVI--RRLPRRIYV 859
Cdd:cd19505   88 IIWIPNIHELnvnrSTQNLEEDPKLLLGLLLNYLS---RDFEKSSTRNILVIASTHIPQKVDPALIapNRLDTCINI 161
McrB COG1401
5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB ...
 524-748 5.30e-05

5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms];


Pssm-ID: 441011 [Multi-domain]  Cd Length: 477  Bit Score: 47.07  E-value: 5.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 524 KGLTEGFTGRGKSEENEIYKLFTNVMRLHPPKEEDTLRLFKKQLGEDRRIVISRSNINELLKALEEHELLCTDLYQVNTD 603
Cdd:COG1401    9 KFLIVGLRLKPLESEDAVRELGIRADDLRGAAELATRLAERLSEELLRADRAARATELVEELSAALEVVVLLLDLEKVEL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 604 GVILTKQKAEKAIGWAKNHYLASCPVPLVKGGRLSLPRESLEISIARLRKLEDNSLKPSQNLKNIAKDEYERNFVSAVVA 683
Cdd:COG1401   89 NEKLALSEAAVAIEELYELEADSEIEAVGLLLELAERSDALEALERARLLLELADLEERAALETEVLEALEAELEELLAA 168

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 186489959 684 PGEIGVKFEDIGALEDVKKALNELVILPMRRPELFARGN---------LLRPCKGILLFGPPGTGKTLLAKALA 748
Cdd:COG1401  169 PEDLSADALAAELSAAEELYSEDLESEDDYLKDLLREKFeetleaflaALKTKKNVILAGPPGTGKTYLARRLA 242
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
719-751 5.66e-05

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 45.54  E-value: 5.66e-05
                         10        20        30
                 ....*....|....*....|....*....|...
gi 186489959 719 ARGNLLRPCKGILLFGPPGTGKTLLAKALATEA 751
Cdd:COG1484   91 ATLDFIERGENLILLGPPGTGKTHLAIALGHEA 123
PRK04195 PRK04195
replication factor C large subunit; Provisional
 725-807 1.66e-04

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 45.30  E-value: 1.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 725 RPCKGILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKwfGDAEK------LTKALFSFATKLapviIFVDEIDSL 798
Cdd:PRK04195  37 KPKKALLLYGPPGVGKTSLAHALANDYGWEVIELNASDQRTA--DVIERvageaaTSGSLFGARRKL----ILLDEVDGI 110

                         90
                 ....*....|.
gi 186489959 799 LGA--RGGSSE 807
Cdd:PRK04195 111 HGNedRGGARA 121
RuvB COG2255
Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, ...
 730-795 1.71e-04

Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, recombination and repair];


Pssm-ID: 441856 [Multi-domain]  Cd Length: 337  Bit Score: 45.07  E-value: 1.71e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 186489959 730 ILLFGPPGTGKTLLAKALATEAGANFISITGSTLtskwfgdaEKlTKALFSFATKLAPV-IIFVDEI 795
Cdd:COG2255   57 VLLYGPPGLGKTTLAHIIANEMGVNIRITSGPAI--------EK-PGDLAAILTNLEEGdVLFIDEI 114
T7SS_EccA TIGR03922
type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the ...
 692-939 6.51e-04

type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccA1, EccA2, etc. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 188437 [Multi-domain]  Cd Length: 557  Bit Score: 43.68  E-value: 6.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959  692 EDIGaLEDVK---KALNELVILPMRRPElfaRG-NLLRPCKGILLFGPPGTGKTLLAKALATE-AG------ANFISITG 760
Cdd:TIGR03922 277 EQIG-LERVKrqvAALKSSTAMALARAE---RGlPVAQTSNHMLFAGPPGTGKTTIARVVAKIyCGlgvlrkPLVREVSR 352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959  761 STLTSKWFGDAEKLTKALFSFATKlapVIIFVDEIDSLLGARGGSseheatrrmRNEF-MAAWDGLRSK---DSQRILIL 836
Cdd:TIGR03922 353 ADLIGQYIGESEAKTNEIIDSALG---GVLFLDEAYTLVETGYGQ---------KDPFgLEAIDTLLARmenDRDRLVVI 420

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959  837 GA-----TNRPFDLDDAVIRRLPRRIYVDLPDAENRLKILKIFLTPEnlESDFQ----------FEKLAK-ETEGYSGSD 900
Cdd:TIGR03922 421 GAgyrkdLDKFLEVNEGLRSRFTRVIEFPSYSPDELVEIARRMATER--DSVLDdaaadalleaATTLAQdTTPDANGDL 498

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 186489959  901 LKNLCIAAAYRPVQELLQ--EEQKGARAEASPGLRSLSLDD 939
Cdd:TIGR03922 499 RRGLDIAGNGRFVRNVVEraEEERDFRLDHSDRLDAVTVDD 539
ClpX COG1219
ATP-dependent protease Clp, ATPase subunit ClpX [Posttranslational modification, protein ...
 730-796 7.31e-04

ATP-dependent protease Clp, ATPase subunit ClpX [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440832 [Multi-domain]  Cd Length: 409  Bit Score: 43.11  E-value: 7.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 730 ILLFGPPGTGKTLLAKALA---------------TEAG----------------ANFisitgstltskwfgDAEKLTKAl 778
Cdd:COG1219  112 ILLIGPTGSGKTLLAQTLArildvpfaiadattlTEAGyvgedvenillkllqaADY--------------DVEKAERG- 176

                         90
                 ....*....|....*...
gi 186489959 779 fsfatklapvIIFVDEID 796
Cdd:COG1219  177 ----------IIYIDEID 184
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
730-758 7.59e-04

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 41.05  E-value: 7.59e-04
                         10        20
                 ....*....|....*....|....*....
gi 186489959 730 ILLFGPPGTGKTLLAKALATEAGANFISI 758
Cdd:COG0645    2 ILVCGLPGSGKSTLARALAERLGAVRLRS 30
ruvB TIGR00635
Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions ...
 730-798 8.32e-04

Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions are known are 5'-3' DNA helicases that, as part of a complex with RuvA homologs serve as a 5'-3' Holliday junction helicase. RuvA specifically binds Holliday junctions as a sandwich of two tetramers and maintains the configuration of the junction. It forms a complex with two hexameric rings of RuvB, the subunit that contains helicase activity. The complex drives ATP-dependent branch migration of the Holliday junction recombination intermediate. The endonuclease RuvC resolves junctions. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129721 [Multi-domain]  Cd Length: 305  Bit Score: 42.67  E-value: 8.32e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959  730 ILLFGPPGTGKTLLAKALATEAGANFISITGSTLTSKwfGDaekLTKALfsfaTKLAP-VIIFVDEIDSL 798
Cdd:TIGR00635  33 LLLYGPPGLGKTTLAHIIANEMGVNLKITSGPALEKP--GD---LAAIL----TNLEEgDVLFIDEIHRL 93
IS21_help_AAA NF038214
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was ...
 719-751 8.74e-04

IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was built to hit full-length AAA+ ATPases of IS21 family IS (insertion sequence) elements.


Pssm-ID: 439516  Cd Length: 232  Bit Score: 42.07  E-value: 8.74e-04
                         10        20        30
                 ....*....|....*....|....*....|...
gi 186489959 719 ARGNLLRPCKGILLFGPPGTGKTLLAKALATEA 751
Cdd:NF038214  82 ATLDFIERAENVLLLGPPGTGKTHLAIALGYAA 114
YifB COG0606
Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational ...
 730-749 9.09e-04

Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440371 [Multi-domain]  Cd Length: 502  Bit Score: 43.11  E-value: 9.09e-04
                         10        20
                 ....*....|....*....|
gi 186489959 730 ILLFGPPGTGKTLLAKALAT 749
Cdd:COG0606  214 LLMIGPPGSGKTMLARRLPG 233
clpX PRK05342
ATP-dependent Clp protease ATP-binding subunit ClpX;
730-796 9.79e-04

ATP-dependent Clp protease ATP-binding subunit ClpX;


Pssm-ID: 235422 [Multi-domain]  Cd Length: 412  Bit Score: 42.84  E-value: 9.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 730 ILLFGPPGTGKTLLAKALA---------------TEAG----------------ANFisitgstltskwfgDAEKLTKAl 778
Cdd:PRK05342 111 ILLIGPTGSGKTLLAQTLArildvpfaiadattlTEAGyvgedvenillkllqaADY--------------DVEKAQRG- 175

                         90
                 ....*....|....*...
gi 186489959 779 fsfatklapvIIFVDEID 796
Cdd:PRK05342 176 ----------IVYIDEID 183
RecA-like_Lon cd19500
lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an ...
 697-758 1.47e-03

lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an evolutionarily conserved ATP-dependent serine protease, present in bacteria and eukaryotic mitochondria and peroxisomes, which mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Lon protease is both an ATP-dependent peptidase and a protein-activated ATPase. This RecA-like Lon domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410908 [Multi-domain]  Cd Length: 182  Bit Score: 40.62  E-value: 1.47e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 186489959 697 LEDVKKalnelvilpmRRPELFARGNLLRPCKG-ILLF-GPPGTGKTLLAKALATEAGANFISI 758
Cdd:cd19500   15 LEDVKE----------RILEYLAVRKLKGSMKGpILCLvGPPGVGKTSLGKSIARALGRKFVRI 68
Mg_chelatase pfam01078
Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that ...
 730-749 2.39e-03

Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that catalyzes the insertion of Mg2+ into protoporphyrin IX. This is the first unique step in the synthesis of (bacterio)chlorophyll. Due to this, it is thought that Mg-chelatase has an important role in channelling inter- mediates into the (bacterio)chlorophyll branch in response to conditions suitable for photosynthetic growth. ChlI and BchD have molecular weight between 38-42 kDa.


Pssm-ID: 426032 [Multi-domain]  Cd Length: 207  Bit Score: 40.21  E-value: 2.39e-03
                          10        20
                  ....*....|....*....|
gi 186489959  730 ILLFGPPGTGKTLLAKALAT 749
Cdd:pfam01078  25 LLMIGPPGSGKTMLAKRLPG 44
44 PHA02544
clamp loader, small subunit; Provisional
 730-761 2.46e-03

clamp loader, small subunit; Provisional


Pssm-ID: 222866 [Multi-domain]  Cd Length: 316  Bit Score: 41.13  E-value: 2.46e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 186489959 730 ILLFGP-PGTGKTLLAKALATEAGANFISITGS 761
Cdd:PHA02544  45 MLLHSPsPGTGKTTVAKALCNEVGAEVLFVNGS 77
ExeA COG3267
Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, ...
 730-794 4.25e-03

Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 442498 [Multi-domain]  Cd Length: 261  Bit Score: 40.16  E-value: 4.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 730 ILLFGPPGTGKTLLAKALATEAGANF--ISITGSTLTSKWF--------------GDAEKLTKALFSFATKLA----PVI 789
Cdd:COG3267   46 VVLTGEVGTGKTTLLRRLLERLPDDVkvAYIPNPQLSPAELlraiadelglepkgASKADLLRQLQEFLLELAaagrRVV 125


                 ....*
gi 186489959 790 IFVDE 794
Cdd:COG3267  126 LIIDE 130
AAA_2 pfam07724
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ...
 730-796 4.38e-03

AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400187 [Multi-domain]  Cd Length: 168  Bit Score: 39.10  E-value: 4.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959  730 ILLFGPPGTGKTLLAKALATEAG---ANFISITGSTLTSKW--------------FGDAEKLTKALfsfaTKLAPVIIFV 792
Cdd:pfam07724   6 FLFLGPTGVGKTELAKALAELLFgdeRALIRIDMSEYMEEHsvsrligappgyvgYEEGGQLTEAV----RRKPYSIVLI 81


                  ....
gi 186489959  793 DEID 796
Cdd:pfam07724  82 DEIE 85
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 730-856 4.90e-03

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 38.44  E-value: 4.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959  730 ILLFGPPGTGKTLLAKALATEAGANFIS-------ITGSTLTSK-WFGDAEKLTKA-LFSFATKLA----PVII---FVD 793
Cdd:pfam13671   2 ILLVGLPGSGKSTLARRLLEELGAVRLSsdderkrLFGEGRPSIsYYTDATDRTYErLHELARIALragrPVILdatNLR 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 186489959  794 EiDSLLGARGGSSEHEATRRMRnEFMAAWDGLRSKDSQRiliLGATNRPFDLDDAVIRRLPRR 856
Cdd:pfam13671  82 R-DERARLLALAREYGVPVRIV-VFEAPEEVLRERLAAR---ARAGGDPSDVPEEVLDRQKAR 139
PRK13341 PRK13341
AAA family ATPase;
716-758 5.71e-03

AAA family ATPase;


Pssm-ID: 237354 [Multi-domain]  Cd Length: 725  Bit Score: 40.42  E-value: 5.71e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 186489959 716 ELFARGNLLRpcKGI--------LLFGPPGTGKTLLAKALATEAGANFISI 758
Cdd:PRK13341  35 HILGEGRLLR--RAIkadrvgslILYGPPGVGKTTLARIIANHTRAHFSSL 83
AAA_22 pfam13401
AAA domain;
730-798 6.06e-03

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 38.09  E-value: 6.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959  730 ILLFGPPGTGKTLLAKALA---TEAGANFISITGSTLTS-----KWF-------GDAEKLTKALFSF------ATKLAPV 788
Cdd:pfam13401   8 LVLTGESGTGKTTLLRRLLeqlPEVRDSVVFVDLPSGTSpkdllRALlralglpLSGRLSKEELLAAlqqlllALAVAVV 87

                          90
                  ....*....|
gi 186489959  789 IIfVDEIDSL 798
Cdd:pfam13401  88 LI-IDEAQHL 96
clpA PRK11034
ATP-dependent Clp protease ATP-binding subunit; Provisional
 668-871 7.42e-03

ATP-dependent Clp protease ATP-binding subunit; Provisional


Pssm-ID: 236828 [Multi-domain]  Cd Length: 758  Bit Score: 40.21  E-value: 7.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 668 IAKDEYERNFVSAVVAPGEIGVKFEDigALEDVKKALNELV----ILPM--RRPELFARGNLL--RPCKGILLFGPPGTG 739
Cdd:PRK11034 142 TRKDEPSQSSDPGSQPNSEEQAGGEE--RMENFTTNLNQLArvggIDPLigREKELERAIQVLcrRRKNNPLLVGESGVG 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 186489959 740 KTLLAKALA--------TEAGANFISIT---GSTLT-SKWFGDAEKLTKALFSFATKLAPVIIFVDEIDSLLGARGGSSE 807
Cdd:PRK11034 220 KTAIAEGLAwrivqgdvPEVMADCTIYSldiGSLLAgTKYRGDFEKRFKALLKQLEQDTNSILFIDEIHTIIGAGAASGG 299

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 186489959 808 HEATRRMRNEFMAawdglrskdSQRILILGAT-----NRPFDLDDAVIRRLpRRIYVDLPDAENRLKIL 871
Cdd:PRK11034 300 QVDAANLIKPLLS---------SGKIRVIGSTtyqefSNIFEKDRALARRF-QKIDITEPSIEETVQII 358
RNA_helicase pfam00910
RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding ...
 730-768 7.46e-03

RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding during viral RNA replication. Members of this family are found in a variety of single stranded RNA viruses.


Pssm-ID: 459992  Cd Length: 102  Bit Score: 36.81  E-value: 7.46e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 186489959  730 ILLFGPPGTGKTLLAKALATEAGANFISITGST----LTSKWF 768
Cdd:pfam00910   1 IWLYGPPGCGKSTLAKYLARALLKKLGLPKDSVysrnPDDDFW 43
RecA-like_ClpX cd19497
ATP-dependent Clp protease ATP-binding subunit ClpX; ClpX is a component of the ATP-dependent ...
 730-796 9.41e-03

ATP-dependent Clp protease ATP-binding subunit ClpX; ClpX is a component of the ATP-dependent protease ClpXP. In ClpXP, ClpX ATPase serves to specifically recognize, unfold, and translocate protein substrates into the chamber of ClpP protease for degradation. This RecA-like_ClpX domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410905 [Multi-domain]  Cd Length: 251  Bit Score: 39.12  E-value: 9.41e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 186489959 730 ILLFGPPGTGKTLLAKALATEAGANFISITGSTLT-SKWFG-DAEK-----LTKALFSFAtKLAPVIIFVDEID 796
Cdd:cd19497   53 ILLIGPTGSGKTLLAQTLAKILDVPFAIADATTLTeAGYVGeDVENillklLQAADYDVE-RAQRGIVYIDEID 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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