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Conserved domains on  [gi|183396797|ref|NP_001116859|]
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keratin-associated protein 2-1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Keratin_B2 super family cl37504
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 2-128 3.15e-16

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


The actual alignment was detected with superfamily member pfam01500:

Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 70.20  E-value: 3.15e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 183396797    2 TGSCCGSTFSSLSYGGGCCQPCCCRDPCCCRPVTCQTTVCRPVTCVPRCTRPICEP-----CRRPVCCDPCSLQEGC--- 73
Cdd:pfam01500   6 TSFCGFPTCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQPccqtsCCQPTCCQTSSCQTGCggi 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 183396797   74 -----------------CRPITCCPSSCTAVVCRPCCWATTCCQPVSVQSPCCRPPCGQPTPCSTTCRTSSC 128
Cdd:pfam01500  86 gygqegssgavssrtrwCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCGQSCCRPACCCQCS 157
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 2-128 3.15e-16

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 70.20  E-value: 3.15e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 183396797    2 TGSCCGSTFSSLSYGGGCCQPCCCRDPCCCRPVTCQTTVCRPVTCVPRCTRPICEP-----CRRPVCCDPCSLQEGC--- 73
Cdd:pfam01500   6 TSFCGFPTCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQPccqtsCCQPTCCQTSSCQTGCggi 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 183396797   74 -----------------CRPITCCPSSCTAVVCRPCCWATTCCQPVSVQSPCCRPPCGQPTPCSTTCRTSSC 128
Cdd:pfam01500  86 gygqegssgavssrtrwCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCGQSCCRPACCCQCS 157
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
48-115 5.05e-03

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 35.68  E-value: 5.05e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 183396797  48 PRCTRPICEPCRRPVCCDPCSLQEgCCRPITCCPsSCTAVVCRPCCWATTCCQPVSVQSPCCRPPCGQ 115
Cdd:COG3901  619 AALARRRLWRRRRRECCCGCCCCC-CKCCCIVII-IDGIIIINECCCCCCLCCRRCQDDPLCPPRIKK 684
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 2-128 3.15e-16

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 70.20  E-value: 3.15e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 183396797    2 TGSCCGSTFSSLSYGGGCCQPCCCRDPCCCRPVTCQTTVCRPVTCVPRCTRPICEP-----CRRPVCCDPCSLQEGC--- 73
Cdd:pfam01500   6 TSFCGFPTCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQPccqtsCCQPTCCQTSSCQTGCggi 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 183396797   74 -----------------CRPITCCPSSCTAVVCRPCCWATTCCQPVSVQSPCCRPPCGQPTPCSTTCRTSSC 128
Cdd:pfam01500  86 gygqegssgavssrtrwCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQASCCRPSYCGQSCCRPACCCQCS 157
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
73-117 1.40e-05

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 39.67  E-value: 1.40e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 183396797   73 CCRPITCCPSSCTAVVCRPCCWATTCCQPVSVQSPCCRPPCGQPT 117
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
58-102 5.60e-05

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 38.13  E-value: 5.60e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 183396797   58 CRRPVCCDPCSLQEGCCRPITCCPSSCTAVVCRPCCWATTCCQPV 102
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
79-123 9.69e-04

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 34.67  E-value: 9.69e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 183396797   79 CCPSSCtavvCRPCCWATTCCQPVSVQSPCCRPPCGQPTPCSTTC 123
Cdd:pfam13885   1 CCQPSC----CQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSC 41
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
89-128 1.36e-03

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 34.28  E-value: 1.36e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 183396797   89 CRPCCWATTCCQPVSVQSPCCRPPCGQPTPCSTTCRTSSC 128
Cdd:pfam13885   2 CQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSC 41
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 4-96 2.59e-03

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 35.92  E-value: 2.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 183396797    4 SCCGSTFSSLSYGGGCCQPCCCRDPCCCRPVTCQTTVCRPVTCVPRCTRPIC--EPCRRPVCCDPCSLQEGCCRPITCCP 81
Cdd:pfam01500  66 SCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVSSRTRWCRPDCRVEGTCLPPCcvVSCTPPTCCQLHHAQASCCRPSYCGQ 145

                          90
                  ....*....|....*
gi 183396797   82 SSCTAVVCRPCCWAT 96
Cdd:pfam01500 146 SCCRPACCCQCSEPT 160
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
48-115 5.05e-03

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 35.68  E-value: 5.05e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 183396797  48 PRCTRPICEPCRRPVCCDPCSLQEgCCRPITCCPsSCTAVVCRPCCWATTCCQPVSVQSPCCRPPCGQ 115
Cdd:COG3901  619 AALARRRLWRRRRRECCCGCCCCC-CKCCCIVII-IDGIIIINECCCCCCLCCRRCQDDPLCPPRIKK 684
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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