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Conserved domains on  [gi|170932485|ref|NP_001116311|]
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sugar transporter SWEET1 isoform c [Homo sapiens]

Protein Classification

SWEET family sugar transporter( domain architecture ID 10503726)

SWEET family sugar transporter similar to plant SWEET bidirectional sugar transporters that mediate both low-affinity uptake and efflux of sugar across the plasma membrane

CATH:  1.20.1280.290
Gene Ontology:  GO:0051119
PubMed:  25988582
SCOP:  3002472

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MtN3_slv pfam03083
Sugar efflux transporter for intercellular exchange; This family includes proteins such as ...
 9-95 3.25e-30

Sugar efflux transporter for intercellular exchange; This family includes proteins such as drosophila saliva, MtN3 involved in root nodule development and a protein involved in activation and expression of recombination activation genes (RAGs). Although the molecular function of these proteins is unknown, they are almost certainly transmembrane proteins. This family contains a region of two transmembrane helices that is found in two copies in most members of the family. This family also contains specific sugar efflux transporters that are essential for the maintenance of animal blood glucose levels, plant nectar production, and plant seed and pollen development. In many organizims it meditaes gluose transport; in Arabidopsis it is necessary for pollen viability; and two of the rice homologs are specifically exploited by bacterial pathogens for virulence by means of direct binding of a bacterial effector to the SWEET promoter.


:

Pssm-ID: 397278  Cd Length: 87  Bit Score: 105.36  E-value: 3.25e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170932485    9 SLIYGACVVFTLGMFSAGLSDLRHMRMTRSVDNVQFLPFLTTEVNNLGWLSYGALKGDGILIVVNTVGAALQTLYILAYL 88
Cdd:pfam03083   1 FLLGILCVVFTVAMFLSPLSILRKIIKTKSTEGMPFLPFLAGLLSASLWLLYGLLKKDGYIIIPNGIGCFLGTIYLILFI 80


                  ....*..
gi 170932485   89 HYCPRKA 95
Cdd:pfam03083  81 VYPPKKA 87
MtN3_slv pfam03083
Sugar efflux transporter for intercellular exchange; This family includes proteins such as ...
 67-159 1.26e-19

Sugar efflux transporter for intercellular exchange; This family includes proteins such as drosophila saliva, MtN3 involved in root nodule development and a protein involved in activation and expression of recombination activation genes (RAGs). Although the molecular function of these proteins is unknown, they are almost certainly transmembrane proteins. This family contains a region of two transmembrane helices that is found in two copies in most members of the family. This family also contains specific sugar efflux transporters that are essential for the maintenance of animal blood glucose levels, plant nectar production, and plant seed and pollen development. In many organizims it meditaes gluose transport; in Arabidopsis it is necessary for pollen viability; and two of the rice homologs are specifically exploited by bacterial pathogens for virulence by means of direct binding of a bacterial effector to the SWEET promoter.


:

Pssm-ID: 397278  Cd Length: 87  Bit Score: 78.01  E-value: 1.26e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170932485   67 GILIVVNTVGAALQTLYILAylhycprkaKVIQTKSTQCLSYPLTIATLLTSASWCLYGFRLRDPYIMVSNFPGIVTSFI 146
Cdd:pfam03083   4 GILCVVFTVAMFLSPLSILR---------KIIKTKSTEGMPFLPFLAGLLSASLWLLYGLLKKDGYIIIPNGIGCFLGTI 74

                          90
                  ....*....|...
gi 170932485  147 RFWLFWKYPQEQD 159
Cdd:pfam03083  75 YLILFIVYPPKKA 87
 
Name Accession Description Interval E-value
MtN3_slv pfam03083
Sugar efflux transporter for intercellular exchange; This family includes proteins such as ...
 9-95 3.25e-30

Sugar efflux transporter for intercellular exchange; This family includes proteins such as drosophila saliva, MtN3 involved in root nodule development and a protein involved in activation and expression of recombination activation genes (RAGs). Although the molecular function of these proteins is unknown, they are almost certainly transmembrane proteins. This family contains a region of two transmembrane helices that is found in two copies in most members of the family. This family also contains specific sugar efflux transporters that are essential for the maintenance of animal blood glucose levels, plant nectar production, and plant seed and pollen development. In many organizims it meditaes gluose transport; in Arabidopsis it is necessary for pollen viability; and two of the rice homologs are specifically exploited by bacterial pathogens for virulence by means of direct binding of a bacterial effector to the SWEET promoter.


Pssm-ID: 397278  Cd Length: 87  Bit Score: 105.36  E-value: 3.25e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170932485    9 SLIYGACVVFTLGMFSAGLSDLRHMRMTRSVDNVQFLPFLTTEVNNLGWLSYGALKGDGILIVVNTVGAALQTLYILAYL 88
Cdd:pfam03083   1 FLLGILCVVFTVAMFLSPLSILRKIIKTKSTEGMPFLPFLAGLLSASLWLLYGLLKKDGYIIIPNGIGCFLGTIYLILFI 80


                  ....*..
gi 170932485   89 HYCPRKA 95
Cdd:pfam03083  81 VYPPKKA 87
MtN3_slv pfam03083
Sugar efflux transporter for intercellular exchange; This family includes proteins such as ...
 67-159 1.26e-19

Sugar efflux transporter for intercellular exchange; This family includes proteins such as drosophila saliva, MtN3 involved in root nodule development and a protein involved in activation and expression of recombination activation genes (RAGs). Although the molecular function of these proteins is unknown, they are almost certainly transmembrane proteins. This family contains a region of two transmembrane helices that is found in two copies in most members of the family. This family also contains specific sugar efflux transporters that are essential for the maintenance of animal blood glucose levels, plant nectar production, and plant seed and pollen development. In many organizims it meditaes gluose transport; in Arabidopsis it is necessary for pollen viability; and two of the rice homologs are specifically exploited by bacterial pathogens for virulence by means of direct binding of a bacterial effector to the SWEET promoter.


Pssm-ID: 397278  Cd Length: 87  Bit Score: 78.01  E-value: 1.26e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170932485   67 GILIVVNTVGAALQTLYILAylhycprkaKVIQTKSTQCLSYPLTIATLLTSASWCLYGFRLRDPYIMVSNFPGIVTSFI 146
Cdd:pfam03083   4 GILCVVFTVAMFLSPLSILR---------KIIKTKSTEGMPFLPFLAGLLSASLWLLYGLLKKDGYIIIPNGIGCFLGTI 74

                          90
                  ....*....|...
gi 170932485  147 RFWLFWKYPQEQD 159
Cdd:pfam03083  75 YLILFIVYPPKKA 87
SWEET COG4095
Sugar transporter, SemiSWEET family, contains PQ motif [Carbohydrate transport and metabolism]; ...
 84-154 4.03e-06

Sugar transporter, SemiSWEET family, contains PQ motif [Carbohydrate transport and metabolism];


Pssm-ID: 443271  Cd Length: 83  Bit Score: 42.87  E-value: 4.03e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 170932485  84 ILAYLHYCPRKAKVIQTKSTQCLSYPLTIATLLTSASWCLYGFRLRDPYIMVSNFPGIVTSFIRFWLFWKY 154
Cdd:COG4095   12 ILTTISFLPQVIKTWKTKSTKDISLGMYLIFTTGVALWLIYGILIGDLPIILANAITLVLALIILVLKLRY 82
SWEET COG4095
Sugar transporter, SemiSWEET family, contains PQ motif [Carbohydrate transport and metabolism]; ...
 36-87 9.94e-03

Sugar transporter, SemiSWEET family, contains PQ motif [Carbohydrate transport and metabolism];


Pssm-ID: 443271  Cd Length: 83  Bit Score: 33.63  E-value: 9.94e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 170932485  36 TRSVDNVQFLPFLTTEVNNLGWLSYGALKGDGILIVVNTVGAALqTLYILAY 87
Cdd:COG4095   28 TKSTKDISLGMYLIFTTGVALWLIYGILIGDLPIILANAITLVL-ALIILVL 78
 
Name Accession Description Interval E-value
MtN3_slv pfam03083
Sugar efflux transporter for intercellular exchange; This family includes proteins such as ...
 9-95 3.25e-30

Sugar efflux transporter for intercellular exchange; This family includes proteins such as drosophila saliva, MtN3 involved in root nodule development and a protein involved in activation and expression of recombination activation genes (RAGs). Although the molecular function of these proteins is unknown, they are almost certainly transmembrane proteins. This family contains a region of two transmembrane helices that is found in two copies in most members of the family. This family also contains specific sugar efflux transporters that are essential for the maintenance of animal blood glucose levels, plant nectar production, and plant seed and pollen development. In many organizims it meditaes gluose transport; in Arabidopsis it is necessary for pollen viability; and two of the rice homologs are specifically exploited by bacterial pathogens for virulence by means of direct binding of a bacterial effector to the SWEET promoter.


Pssm-ID: 397278  Cd Length: 87  Bit Score: 105.36  E-value: 3.25e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170932485    9 SLIYGACVVFTLGMFSAGLSDLRHMRMTRSVDNVQFLPFLTTEVNNLGWLSYGALKGDGILIVVNTVGAALQTLYILAYL 88
Cdd:pfam03083   1 FLLGILCVVFTVAMFLSPLSILRKIIKTKSTEGMPFLPFLAGLLSASLWLLYGLLKKDGYIIIPNGIGCFLGTIYLILFI 80


                  ....*..
gi 170932485   89 HYCPRKA 95
Cdd:pfam03083  81 VYPPKKA 87
MtN3_slv pfam03083
Sugar efflux transporter for intercellular exchange; This family includes proteins such as ...
 67-159 1.26e-19

Sugar efflux transporter for intercellular exchange; This family includes proteins such as drosophila saliva, MtN3 involved in root nodule development and a protein involved in activation and expression of recombination activation genes (RAGs). Although the molecular function of these proteins is unknown, they are almost certainly transmembrane proteins. This family contains a region of two transmembrane helices that is found in two copies in most members of the family. This family also contains specific sugar efflux transporters that are essential for the maintenance of animal blood glucose levels, plant nectar production, and plant seed and pollen development. In many organizims it meditaes gluose transport; in Arabidopsis it is necessary for pollen viability; and two of the rice homologs are specifically exploited by bacterial pathogens for virulence by means of direct binding of a bacterial effector to the SWEET promoter.


Pssm-ID: 397278  Cd Length: 87  Bit Score: 78.01  E-value: 1.26e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 170932485   67 GILIVVNTVGAALQTLYILAylhycprkaKVIQTKSTQCLSYPLTIATLLTSASWCLYGFRLRDPYIMVSNFPGIVTSFI 146
Cdd:pfam03083   4 GILCVVFTVAMFLSPLSILR---------KIIKTKSTEGMPFLPFLAGLLSASLWLLYGLLKKDGYIIIPNGIGCFLGTI 74

                          90
                  ....*....|...
gi 170932485  147 RFWLFWKYPQEQD 159
Cdd:pfam03083  75 YLILFIVYPPKKA 87
SWEET COG4095
Sugar transporter, SemiSWEET family, contains PQ motif [Carbohydrate transport and metabolism]; ...
 84-154 4.03e-06

Sugar transporter, SemiSWEET family, contains PQ motif [Carbohydrate transport and metabolism];


Pssm-ID: 443271  Cd Length: 83  Bit Score: 42.87  E-value: 4.03e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 170932485  84 ILAYLHYCPRKAKVIQTKSTQCLSYPLTIATLLTSASWCLYGFRLRDPYIMVSNFPGIVTSFIRFWLFWKY 154
Cdd:COG4095   12 ILTTISFLPQVIKTWKTKSTKDISLGMYLIFTTGVALWLIYGILIGDLPIILANAITLVLALIILVLKLRY 82
SWEET COG4095
Sugar transporter, SemiSWEET family, contains PQ motif [Carbohydrate transport and metabolism]; ...
 36-87 9.94e-03

Sugar transporter, SemiSWEET family, contains PQ motif [Carbohydrate transport and metabolism];


Pssm-ID: 443271  Cd Length: 83  Bit Score: 33.63  E-value: 9.94e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 170932485  36 TRSVDNVQFLPFLTTEVNNLGWLSYGALKGDGILIVVNTVGAALqTLYILAY 87
Cdd:COG4095   28 TKSTKDISLGMYLIFTTGVALWLIYGILIGDLPIILANAITLVL-ALIILVL 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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