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Conserved domains on  [gi|169234756|ref|NP_001108485|]
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selenoprotein M precursor [Rattus norvegicus]

Protein Classification

Sep15_SelM domain-containing protein( domain architecture ID 10555966)

Sep15_SelM domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sep15_SelM pfam08806
Sep15/SelM redox domain; Sep15 and SelM are eukaryotic selenoproteins that have a ...
 40-114 1.55e-35

Sep15/SelM redox domain; Sep15 and SelM are eukaryotic selenoproteins that have a thioredoxin-like domain and a surface accessible active site redox motif. This suggests that they function as thiol-disulphide isomerases involved in disulphide bond formation in the endoplasmic reticulum. Structurally it resembles the thioredoxin-fold.


:

Pssm-ID: 462607  Cd Length: 75  Bit Score: 117.67  E-value: 1.55e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 169234756   40 GRVETCGGUQLNRLKEVKAFVTQDIQLYHNLVMKHLPGADPELVLLSRNYQELERIPLSQMTRDEINALVQELGF 114
Cdd:pfam08806   1 AAVLEVCGCKLNRYPEVKAFVKSDIPKFPNLEVKYVRGAPPELVLLDDDGEEVERISIEKWDTDEINEFLKEKGF 75
 
Name Accession Description Interval E-value
Sep15_SelM pfam08806
Sep15/SelM redox domain; Sep15 and SelM are eukaryotic selenoproteins that have a ...
 40-114 1.55e-35

Sep15/SelM redox domain; Sep15 and SelM are eukaryotic selenoproteins that have a thioredoxin-like domain and a surface accessible active site redox motif. This suggests that they function as thiol-disulphide isomerases involved in disulphide bond formation in the endoplasmic reticulum. Structurally it resembles the thioredoxin-fold.


Pssm-ID: 462607  Cd Length: 75  Bit Score: 117.67  E-value: 1.55e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 169234756   40 GRVETCGGUQLNRLKEVKAFVTQDIQLYHNLVMKHLPGADPELVLLSRNYQELERIPLSQMTRDEINALVQELGF 114
Cdd:pfam08806   1 AAVLEVCGCKLNRYPEVKAFVKSDIPKFPNLEVKYVRGAPPELVLLDDDGEEVERISIEKWDTDEINEFLKEKGF 75
 
Name Accession Description Interval E-value
Sep15_SelM pfam08806
Sep15/SelM redox domain; Sep15 and SelM are eukaryotic selenoproteins that have a ...
 40-114 1.55e-35

Sep15/SelM redox domain; Sep15 and SelM are eukaryotic selenoproteins that have a thioredoxin-like domain and a surface accessible active site redox motif. This suggests that they function as thiol-disulphide isomerases involved in disulphide bond formation in the endoplasmic reticulum. Structurally it resembles the thioredoxin-fold.


Pssm-ID: 462607  Cd Length: 75  Bit Score: 117.67  E-value: 1.55e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 169234756   40 GRVETCGGUQLNRLKEVKAFVTQDIQLYHNLVMKHLPGADPELVLLSRNYQELERIPLSQMTRDEINALVQELGF 114
Cdd:pfam08806   1 AAVLEVCGCKLNRYPEVKAFVKSDIPKFPNLEVKYVRGAPPELVLLDDDGEEVERISIEKWDTDEINEFLKEKGF 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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