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Conserved domains on  [gi|1379048692|ref|NP_001107879|]
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carbonic anhydrase 4a precursor [Danio rerio]

Protein Classification

alpha_CA_IV_XV_like domain-containing protein( domain architecture ID 10123201)

alpha_CA_IV_XV_like domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
alpha_CA_IV_XV_like cd03117
Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are ...
49-279 1.97e-138

Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This subgroup, restricted to animals, contains isozyme IV and similar proteins such as mouse CA XV. Isozymes IV is attached to membranes via a glycosylphosphatidylinositol (GPI) tail. In mammals, Isozyme IV plays crucial roles in kidney and lung function, amongst others. This subgroup also contains the dual domain CA from the giant clam, Tridacna gigas. T. gigas CA plays a role in the movement of inorganic carbon from the surrounding seawater to the symbiotic algae found in the clam's tissues. CA XV is expressed in several species but not in humans or chimps. Similar to isozyme CA IV, CA XV attaches to membranes via a GPI tail.


:

Pssm-ID: 239391  Cd Length: 234  Bit Score: 390.48  E-value: 1.97e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692  49 KDRQSPINIVTKQTKLDERLTPFRFTGYQ-TVFDGTLKNNGHSVQVSIPVPATISGGNLAEPYKAVQFHLHWGISSGPGS 127
Cdd:cd03117     1 GKRQSPINIVTKKVQYDENLTPFTFTGYDdTTTNWTITNNGHTVQVTLPDGAKISGGGLPGTYKALQFHFHWGSNGSPGS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692 128 EHTIDGEQYPMELHIVHMKQKYIRIEDALKDPSGVAVLGFFYEVSSTTNRKYDLFAHALRSVQNTNGNTTLRKISLNQLi 207
Cdd:cd03117    81 EHTIDGERYPMELHIVHIKESYNSLLEALKDSDGLAVLGFFIEEGEEENTNFDPLISALSNIPQKGGSTNLTPFSLRSL- 159
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1379048692 208 LPEVNMTNYYRYDGSLTTPGCTEAVVWTVFEKPIPLDSEQLQAFSSLKFRD---GKPMVGTFRPVQPRNGRVVYR 279
Cdd:cd03117   160 LPSVLLTKYYRYNGSLTTPGCNEAVIWTVFEEPIPISRAQLDAFSTVLFFDtdnGQPMVNNFRPVQPLNGRVVYA 234
 
Name Accession Description Interval E-value
alpha_CA_IV_XV_like cd03117
Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are ...
49-279 1.97e-138

Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This subgroup, restricted to animals, contains isozyme IV and similar proteins such as mouse CA XV. Isozymes IV is attached to membranes via a glycosylphosphatidylinositol (GPI) tail. In mammals, Isozyme IV plays crucial roles in kidney and lung function, amongst others. This subgroup also contains the dual domain CA from the giant clam, Tridacna gigas. T. gigas CA plays a role in the movement of inorganic carbon from the surrounding seawater to the symbiotic algae found in the clam's tissues. CA XV is expressed in several species but not in humans or chimps. Similar to isozyme CA IV, CA XV attaches to membranes via a GPI tail.


Pssm-ID: 239391  Cd Length: 234  Bit Score: 390.48  E-value: 1.97e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692  49 KDRQSPINIVTKQTKLDERLTPFRFTGYQ-TVFDGTLKNNGHSVQVSIPVPATISGGNLAEPYKAVQFHLHWGISSGPGS 127
Cdd:cd03117     1 GKRQSPINIVTKKVQYDENLTPFTFTGYDdTTTNWTITNNGHTVQVTLPDGAKISGGGLPGTYKALQFHFHWGSNGSPGS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692 128 EHTIDGEQYPMELHIVHMKQKYIRIEDALKDPSGVAVLGFFYEVSSTTNRKYDLFAHALRSVQNTNGNTTLRKISLNQLi 207
Cdd:cd03117    81 EHTIDGERYPMELHIVHIKESYNSLLEALKDSDGLAVLGFFIEEGEEENTNFDPLISALSNIPQKGGSTNLTPFSLRSL- 159
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1379048692 208 LPEVNMTNYYRYDGSLTTPGCTEAVVWTVFEKPIPLDSEQLQAFSSLKFRD---GKPMVGTFRPVQPRNGRVVYR 279
Cdd:cd03117   160 LPSVLLTKYYRYNGSLTTPGCNEAVIWTVFEEPIPISRAQLDAFSTVLFFDtdnGQPMVNNFRPVQPLNGRVVYA 234
Carb_anhydrase pfam00194
Eukaryotic-type carbonic anhydrase;
36-280 5.98e-118

Eukaryotic-type carbonic anhydrase;


Pssm-ID: 459707 [Multi-domain]  Cd Length: 252  Bit Score: 339.24  E-value: 5.98e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692  36 GPEKWREVNADCGKDRQSPINIVTKQTKLDERLTPFRFTGYQTVFDG-TLKNNGHSVQVSIPV--PATISGGNLAEPYKA 112
Cdd:pfam00194   2 GPEHWGKVYPSCGGKRQSPINIDTRKVRYDPSLPPLTFQGYDVPPGKnTLTNNGHTVQVSLDDgdPSTISGGPLATRYRL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692 113 VQFHLHWGISSGPGSEHTIDGEQYPMELHIVHMKQKYIRIEDALKDPSGVAVLGFFYEVSSTTNRKYDLFAHALRSVQNT 192
Cdd:pfam00194  82 VQFHFHWGSTDSRGSEHTIDGKRYPAELHIVHYNSKYKSFDEAAKHPDGLAVLGVFFEVGDENNPYLQPIVSALDNIKYK 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692 193 NGNTTLRKISLNQLiLPEvNMTNYYRYDGSLTTPGCTEAVVWTVFEKPIPLDSEQLQAFSSLKFRDGK----PMVGTFRP 268
Cdd:pfam00194 162 GKSVLLPPFDLSDL-LPE-DLTSYYTYNGSLTTPPCSESVTWIVFKEPISISEEQLEAFRTLLFSDGGeeprPLVNNFRP 239
                         250
                  ....*....|..
gi 1379048692 269 VQPRNGRVVYRS 280
Cdd:pfam00194 240 TQPLNGRVVFAS 251
Carb_anhydrase smart01057
Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse ...
22-276 1.97e-101

Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse the reversible hydration of carbon dioxide to bicarbonate.. CAs have essential roles in facilitating the transport of carbon dioxide and protons in the intracellular space, across biological membranes and in the layers of the extracellular space; they are also involved in many other processes, from respiration and photosynthesis in eukaryotes to cyanate degradation in prokaryotes. There are five known evolutionarily distinct CA families (alpha, beta, gamma, delta and epsilon) that have no significant sequence identity and have structurally distinct overall folds. Some CAs are membrane-bound, while others act in the cytosol; there are several related proteins that lack enzymatic activity. The active site of alpha-CAs is well described, consisting of a zinc ion coordinated through 3 histidine residues and a water molecule/hydroxide ion that acts as a potent nucleophile. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site. Beta- and gamma-CAs also employ a zinc hydroxide mechanism, although at least some beta-class enzymes do not have water directly coordinated to the metal ion.


Pssm-ID: 215000 [Multi-domain]  Cd Length: 247  Bit Score: 297.30  E-value: 1.97e-101
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692   22 WCYQTQvscdshcKGPEKWREVNADCGK-DRQSPINIVTKQTKLDERLTPFRFTGYQTVfDGTLKNNGHSVQVSIPVP-A 99
Cdd:smart01057   1 WGYEGK-------NGPEHWGKLDPPFCGgKRQSPIDIVTAEAQYDPSLKPLKLSYDQPT-AKRILNNGHTVQVNFDDDgS 72
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692  100 TISGGNLAEPYKAVQFHLHWGISSGPGSEHTIDGEQYPMELHIVHMKQKyIRIEDALKDPSGVAVLGFFYEVSSTTNRKY 179
Cdd:smart01057  73 TLSGGPLPGRYRLKQFHFHWGGSDSEGSEHTIDGKRFPLELHLVHYNSK-GSFSEAVSKPGGLAVVAVFFKVGAEENPAL 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692  180 DLFAHALRSVQNTNGNTTLRKISLNQLiLPEvNMTNYYRYDGSLTTPGCTEAVVWTVFEKPIPLDSEQLQAFSSLKFRDG 259
Cdd:smart01057 152 QAILDHLPLIKYKGQETELTPFDLSSL-LPA-STRHYYTYNGSLTTPPCSEGVTWIVFKEPITISTEQLEKFRTLLPMEG 229
                          250
                   ....*....|....*...
gi 1379048692  260 K-PMVGTFRPVQPRNGRV 276
Cdd:smart01057 230 NePLVNNARPLQPLNGRV 247
Cah COG3338
Carbonic anhydrase [Inorganic ion transport and metabolism];
2-280 2.34e-62

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 442567 [Multi-domain]  Cd Length: 247  Bit Score: 197.80  E-value: 2.34e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692   2 RCLLSAYLLPLILHACTGADWCYQTQVscdshckGPEKW---REVNADC--GKdRQSPINIvtkQTKLDERLTPFRFTgY 76
Cdd:COG3338     8 ALLLAAALPAAAAAAASAPHWSYEGET-------GPEHWgelSPEFATCatGK-NQSPIDI---RTAIKADLPPLKFD-Y 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692  77 QTVfDGTLKNNGHSVQVSIPVPATISGGNlaEPYKAVQFHLHwgissgPGSEHTIDGEQYPMELHIVHmkqkyiriedal 156
Cdd:COG3338    76 KPT-PLEIVNNGHTIQVNVDPGSTLTVDG--KRYELKQFHFH------TPSEHTINGKSYPMEAHLVH------------ 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692 157 KDPSG-VAVLGFFYEVSsttnRKYDLFAHALRSVQNTNGNTTLR--KISLNQLiLPEvNMTnYYRYDGSLTTPGCTEAVV 233
Cdd:COG3338   135 KDADGeLAVVGVLFEEG----AENPALAKLWANLPLEAGEEVALdaTIDLNDL-LPE-DRS-YYRYSGSLTTPPCSEGVL 207
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1379048692 234 WTVFEKPIPLDSEQLQAFSSLkfrdgkpMVGTFRPVQPRNGRVVYRS 280
Cdd:COG3338   208 WIVLKQPITVSAEQIEAFARL-------YPNNARPVQPLNGRLILES 247
PLN02179 PLN02179
carbonic anhydrase
35-239 1.16e-16

carbonic anhydrase


Pssm-ID: 177835  Cd Length: 235  Bit Score: 77.71  E-value: 1.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692  35 KGPEKWREVNAD---CGKDR-QSPINIVTKQTKL--DERLTpfrfTGYQTVFdGTLKNNGHSVQVSIPVPA---TISGGN 105
Cdd:PLN02179   45 KGPAEWGKLNPQwkvCSTGKyQSPIDLTDERVSLihDQALS----RHYKPAP-AVIQSRGHDVMVSWKGDAgkiTIHQTD 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692 106 laepYKAVQFHLHwgissGPgSEHTIDGEQYPMELHIVHMKQKyiriedalkdpSGVAVLGFFYEVSSTTNRKYDLFaHA 185
Cdd:PLN02179  120 ----YKLVQCHWH-----SP-SEHTINGTSYDLELHMVHTSAS-----------GKTAVVGVLYKLGEPDEFLTKLL-NG 177
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1379048692 186 LRSVQNTNGNTTL---RKISLnqlilpEVNmtNYYRYDGSLTTPGCTEAVVWTVFEK 239
Cdd:PLN02179  178 IKGVGKKEINLGIvdpRDIRF------ETN--NFYRYIGSLTIPPCTEGVIWTVVKR 226
 
Name Accession Description Interval E-value
alpha_CA_IV_XV_like cd03117
Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are ...
49-279 1.97e-138

Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This subgroup, restricted to animals, contains isozyme IV and similar proteins such as mouse CA XV. Isozymes IV is attached to membranes via a glycosylphosphatidylinositol (GPI) tail. In mammals, Isozyme IV plays crucial roles in kidney and lung function, amongst others. This subgroup also contains the dual domain CA from the giant clam, Tridacna gigas. T. gigas CA plays a role in the movement of inorganic carbon from the surrounding seawater to the symbiotic algae found in the clam's tissues. CA XV is expressed in several species but not in humans or chimps. Similar to isozyme CA IV, CA XV attaches to membranes via a GPI tail.


Pssm-ID: 239391  Cd Length: 234  Bit Score: 390.48  E-value: 1.97e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692  49 KDRQSPINIVTKQTKLDERLTPFRFTGYQ-TVFDGTLKNNGHSVQVSIPVPATISGGNLAEPYKAVQFHLHWGISSGPGS 127
Cdd:cd03117     1 GKRQSPINIVTKKVQYDENLTPFTFTGYDdTTTNWTITNNGHTVQVTLPDGAKISGGGLPGTYKALQFHFHWGSNGSPGS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692 128 EHTIDGEQYPMELHIVHMKQKYIRIEDALKDPSGVAVLGFFYEVSSTTNRKYDLFAHALRSVQNTNGNTTLRKISLNQLi 207
Cdd:cd03117    81 EHTIDGERYPMELHIVHIKESYNSLLEALKDSDGLAVLGFFIEEGEEENTNFDPLISALSNIPQKGGSTNLTPFSLRSL- 159
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1379048692 208 LPEVNMTNYYRYDGSLTTPGCTEAVVWTVFEKPIPLDSEQLQAFSSLKFRD---GKPMVGTFRPVQPRNGRVVYR 279
Cdd:cd03117   160 LPSVLLTKYYRYNGSLTTPGCNEAVIWTVFEEPIPISRAQLDAFSTVLFFDtdnGQPMVNNFRPVQPLNGRVVYA 234
Carb_anhydrase pfam00194
Eukaryotic-type carbonic anhydrase;
36-280 5.98e-118

Eukaryotic-type carbonic anhydrase;


Pssm-ID: 459707 [Multi-domain]  Cd Length: 252  Bit Score: 339.24  E-value: 5.98e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692  36 GPEKWREVNADCGKDRQSPINIVTKQTKLDERLTPFRFTGYQTVFDG-TLKNNGHSVQVSIPV--PATISGGNLAEPYKA 112
Cdd:pfam00194   2 GPEHWGKVYPSCGGKRQSPINIDTRKVRYDPSLPPLTFQGYDVPPGKnTLTNNGHTVQVSLDDgdPSTISGGPLATRYRL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692 113 VQFHLHWGISSGPGSEHTIDGEQYPMELHIVHMKQKYIRIEDALKDPSGVAVLGFFYEVSSTTNRKYDLFAHALRSVQNT 192
Cdd:pfam00194  82 VQFHFHWGSTDSRGSEHTIDGKRYPAELHIVHYNSKYKSFDEAAKHPDGLAVLGVFFEVGDENNPYLQPIVSALDNIKYK 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692 193 NGNTTLRKISLNQLiLPEvNMTNYYRYDGSLTTPGCTEAVVWTVFEKPIPLDSEQLQAFSSLKFRDGK----PMVGTFRP 268
Cdd:pfam00194 162 GKSVLLPPFDLSDL-LPE-DLTSYYTYNGSLTTPPCSESVTWIVFKEPISISEEQLEAFRTLLFSDGGeeprPLVNNFRP 239
                         250
                  ....*....|..
gi 1379048692 269 VQPRNGRVVYRS 280
Cdd:pfam00194 240 TQPLNGRVVFAS 251
alpha_CA cd00326
Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are ...
50-278 1.41e-106

Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues and a fourth conserved histidine plays a potential role in proton transfer.


Pssm-ID: 238200  Cd Length: 227  Bit Score: 309.60  E-value: 1.41e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692  50 DRQSPINIVTKQTKLDERLTPFRFTGYQTVfDGTLKNNGHSVQVSIPVPA-TISGGNLAEPYKAVQFHLHWGISSGPGSE 128
Cdd:cd00326     2 KRQSPINIVTSAVVYDPSLPPLNFDYYPTT-SLTLVNNGHTVQVNFDDDGgTLSGGGLPGRYKLVQFHFHWGSENSPGSE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692 129 HTIDGEQYPMELHIVHMKQKYIRIEdALKDPSGVAVLGFFYEVSSTTNRKYDLFAHALRSVQNTNGNTTLRKISLNQLiL 208
Cdd:cd00326    81 HTIDGKRYPLELHLVHYNSDYYSSE-AAKKPGGLAVLGVFFEVGEKENPFLKKILDALPKIKYKGKETTLPPFDLSDL-L 158
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692 209 PEvNMTNYYRYDGSLTTPGCTEAVVWTVFEKPIPLDSEQLQAFSSLKFRDGKPMVGTFRPVQPRNGRVVY 278
Cdd:cd00326   159 PS-SLRDYYTYEGSLTTPPCSEGVTWIVFKEPITISKEQLEAFRSLLDREGKPLVNNYRPVQPLNGRVVY 227
Carb_anhydrase smart01057
Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse ...
22-276 1.97e-101

Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse the reversible hydration of carbon dioxide to bicarbonate.. CAs have essential roles in facilitating the transport of carbon dioxide and protons in the intracellular space, across biological membranes and in the layers of the extracellular space; they are also involved in many other processes, from respiration and photosynthesis in eukaryotes to cyanate degradation in prokaryotes. There are five known evolutionarily distinct CA families (alpha, beta, gamma, delta and epsilon) that have no significant sequence identity and have structurally distinct overall folds. Some CAs are membrane-bound, while others act in the cytosol; there are several related proteins that lack enzymatic activity. The active site of alpha-CAs is well described, consisting of a zinc ion coordinated through 3 histidine residues and a water molecule/hydroxide ion that acts as a potent nucleophile. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site. Beta- and gamma-CAs also employ a zinc hydroxide mechanism, although at least some beta-class enzymes do not have water directly coordinated to the metal ion.


Pssm-ID: 215000 [Multi-domain]  Cd Length: 247  Bit Score: 297.30  E-value: 1.97e-101
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692   22 WCYQTQvscdshcKGPEKWREVNADCGK-DRQSPINIVTKQTKLDERLTPFRFTGYQTVfDGTLKNNGHSVQVSIPVP-A 99
Cdd:smart01057   1 WGYEGK-------NGPEHWGKLDPPFCGgKRQSPIDIVTAEAQYDPSLKPLKLSYDQPT-AKRILNNGHTVQVNFDDDgS 72
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692  100 TISGGNLAEPYKAVQFHLHWGISSGPGSEHTIDGEQYPMELHIVHMKQKyIRIEDALKDPSGVAVLGFFYEVSSTTNRKY 179
Cdd:smart01057  73 TLSGGPLPGRYRLKQFHFHWGGSDSEGSEHTIDGKRFPLELHLVHYNSK-GSFSEAVSKPGGLAVVAVFFKVGAEENPAL 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692  180 DLFAHALRSVQNTNGNTTLRKISLNQLiLPEvNMTNYYRYDGSLTTPGCTEAVVWTVFEKPIPLDSEQLQAFSSLKFRDG 259
Cdd:smart01057 152 QAILDHLPLIKYKGQETELTPFDLSSL-LPA-STRHYYTYNGSLTTPPCSEGVTWIVFKEPITISTEQLEKFRTLLPMEG 229
                          250
                   ....*....|....*...
gi 1379048692  260 K-PMVGTFRPVQPRNGRV 276
Cdd:smart01057 230 NePLVNNARPLQPLNGRV 247
alpha_CA_VI_IX_XII_XIV cd03123
Carbonic anhydrase alpha, isozymes VI, IX, XII and XIV. Carbonic anhydrases (CAs) are ...
36-280 2.41e-77

Carbonic anhydrase alpha, isozymes VI, IX, XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Alpha CAs are mostly monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the secreted CA VI, which is found in saliva, for example, and the membrane proteins CA IX, XII, and XIV.


Pssm-ID: 239397 [Multi-domain]  Cd Length: 248  Bit Score: 236.05  E-value: 2.41e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692  36 GPEKWREVNADCGKDRQSPINIVTKQTKLDERLTPFRFTGYQT--VFDGTLKNNGHSVQVSIPVPATISGGnLAEPYKAV 113
Cdd:cd03123     1 GEDHWPKKYPACGGKRQSPIDIQTDIVQFDPSLPPLELVGYDLpgTEEFTLTNNGHTVQLSLPPTMHIRGG-PGTEYTAA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692 114 QFHLHWG-ISSGPGSEHTIDGEQYPMELHIVHM-KQKYIRIEDALKDPSGVAVLGFFYEVSSTTNRKYDLFAHALRSVQN 191
Cdd:cd03123    80 QLHLHWGgRGSLSGSEHTIDGIRFAAELHIVHYnSDKYSSFDEAADKPDGLAVLAILIEVGYPENTYYEKIISHLHEIKY 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692 192 TNGNTTLRKISLNQLiLPEvNMTNYYRYDGSLTTPGCTEAVVWTVFEKPIPLDSEQLQAFS-SLKFRDGKPMVGTFRPVQ 270
Cdd:cd03123   160 KGQETTVPGFNVREL-LPE-DLSHYYRYEGSLTTPPCYESVLWTVFRDPVTLSKEQLETLEnTLMDTHNKTLQNNYRATQ 237
                         250
                  ....*....|
gi 1379048692 271 PRNGRVVYRS 280
Cdd:cd03123   238 PLNGRVVEAS 247
alpha_CA_I_II_III_XIII cd03119
Carbonic anhydrase alpha, isozymes I, II, and III and XIII. Carbonic anhydrases (CAs) are ...
21-281 1.88e-63

Carbonic anhydrase alpha, isozymes I, II, and III and XIII. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This vertebrate subgroup comprises isozymes I, II, and III, which are cytoplasmic enzymes. CA I, for example, is expressed in erythrocyes of many vertebrates; CA II is the most active cytosolic isozyme; while it is being expressed nearly ubiquitously, it comprises 95% of the renal carbonic anhydrase and is required for renal acidification; CA III has been implicated in protection from the damaging effect of oxidizing agents in hepatocytes. CAXIII may play important physiological roles in several organs.


Pssm-ID: 239393 [Multi-domain]  Cd Length: 259  Bit Score: 201.13  E-value: 1.88e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692  21 DWCYqtqvscDSHcKGPEKWREVNADCGKDRQSPINIVTKQTKLDERLTPFRFTgYQTVFDGTLKNNGHSVQVSIPVP-- 98
Cdd:cd03119     4 HWGY------DSH-NGPEHWHELFPIAKGDRQSPIDIKTKDAKHDPSLKPLSVS-YDPATAKTILNNGHSFNVEFDDTdd 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692  99 -ATISGGNLAEPYKAVQFHLHWGISSGPGSEHTIDGEQYPMELHIVHMKQKYIRIEDALKDPSGVAVLGFFYEVSStTNR 177
Cdd:cd03119    76 rSVLRGGPLTGSYRLRQFHFHWGSSDDHGSEHTVDGVKYAAELHLVHWNSKYGSFGEAAKQPDGLAVVGVFLKVGE-ANP 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692 178 KYDLFAHALRSVQNTNGNTTLRKISLNQLiLPEVnmTNYYRYDGSLTTPGCTEAVVWTVFEKPIPLDSEQLQAFSSLKFR 257
Cdd:cd03119   155 ELQKVLDALDSIKTKGKQAPFTNFDPSCL-LPAS--LDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQMAKFRSLLFN 231
                         250       260
                  ....*....|....*....|....*...
gi 1379048692 258 -DGKP---MVGTFRPVQPRNGRVVyRSS 281
Cdd:cd03119   232 aEGEPpcpMVDNWRPPQPLKGRKV-RAS 258
alpha_CA_IX cd03150
Carbonic anhydrase alpha, isozyme IX. Carbonic anhydrases (CAs) are zinc-containing enzymes ...
36-280 1.71e-62

Carbonic anhydrase alpha, isozyme IX. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Alpha CAs are strictly monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the membrane protein CA IX. CA IX is functionally implicated in tumor growth and survival. CA IX is mainly present in solid tumors and its expression in normal tissues is limited to the mucosa of alimentary tract. CA IX is a transmembrane protein with two extracellular domains: carbonic anhydrase and, a proteoglycan-like segment mediating cell-cell adhesion. There is evidence for an involvement of the MAPK pathway in the regulation of CA9 expression.


Pssm-ID: 239403  Cd Length: 247  Bit Score: 198.26  E-value: 1.71e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692  36 GPEKWREVNADCGKDRQSPINIVTKQTKLDERLTPFRFTGYQT--VFDGTLKNNGHSVQVSIPVPATISGGnLAEPYKAV 113
Cdd:cd03150     1 GQPPWPSVSPACAGRFQSPVDIRPHLVAFCPALRPLELLGFDLppSPSLRLLNNGHTVQLSLPSGLRMALG-PGQEYRAL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692 114 QFHLHWGISSGPGSEHTIDGEQYPMELHIVHMKQKYIRIEDALKDPSGVAVLGFFYEVSSTTNRKYDLFAHALRSVQNTN 193
Cdd:cd03150    80 QLHLHWGAAGRPGSEHTVDGHRFPAEIHVVHLSTAFANLDEALGRPGGLAVLAAFLAEGLHENSAYEQLLSRLSEISEEE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692 194 GNTTLRKISLNQLiLPEvNMTNYYRYDGSLTTPGCTEAVVWTVFEKPIPLDSEQLQAFS-SLKFRDGKPMVGTFRPVQPR 272
Cdd:cd03150   160 SETVVPGLDVSAL-LPS-DLSRYFRYEGSLTTPPCAQGVIWTVFNQTVRLSAKQLHTLSdSLWGPHDSRLQLNFRATQPL 237

                  ....*...
gi 1379048692 273 NGRVVYRS 280
Cdd:cd03150   238 NGRKIEAS 245
Cah COG3338
Carbonic anhydrase [Inorganic ion transport and metabolism];
2-280 2.34e-62

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 442567 [Multi-domain]  Cd Length: 247  Bit Score: 197.80  E-value: 2.34e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692   2 RCLLSAYLLPLILHACTGADWCYQTQVscdshckGPEKW---REVNADC--GKdRQSPINIvtkQTKLDERLTPFRFTgY 76
Cdd:COG3338     8 ALLLAAALPAAAAAAASAPHWSYEGET-------GPEHWgelSPEFATCatGK-NQSPIDI---RTAIKADLPPLKFD-Y 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692  77 QTVfDGTLKNNGHSVQVSIPVPATISGGNlaEPYKAVQFHLHwgissgPGSEHTIDGEQYPMELHIVHmkqkyiriedal 156
Cdd:COG3338    76 KPT-PLEIVNNGHTIQVNVDPGSTLTVDG--KRYELKQFHFH------TPSEHTINGKSYPMEAHLVH------------ 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692 157 KDPSG-VAVLGFFYEVSsttnRKYDLFAHALRSVQNTNGNTTLR--KISLNQLiLPEvNMTnYYRYDGSLTTPGCTEAVV 233
Cdd:COG3338   135 KDADGeLAVVGVLFEEG----AENPALAKLWANLPLEAGEEVALdaTIDLNDL-LPE-DRS-YYRYSGSLTTPPCSEGVL 207
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1379048692 234 WTVFEKPIPLDSEQLQAFSSLkfrdgkpMVGTFRPVQPRNGRVVYRS 280
Cdd:COG3338   208 WIVLKQPITVSAEQIEAFARL-------YPNNARPVQPLNGRLILES 247
alpha_CA_VI cd03125
Carbonic anhydrase alpha, isozyme VI. Carbonic anhydrases (CAs) are zinc-containing enzymes ...
36-277 1.61e-61

Carbonic anhydrase alpha, isozyme VI. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the secreted CA VI, which is found in saliva.


Pssm-ID: 239399  Cd Length: 249  Bit Score: 195.77  E-value: 1.61e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692  36 GPEKWREVNADCGKDRQSPINIVTKQTKLDERLTPFRFTGYQT-VFDGTLKNNGHSVQVSIPVPATISGGnLAEPYKAVQ 114
Cdd:cd03125     1 DESHWPEKYPACGGKRQSPIDIQRREVRFNPSLLQLELVGYEKeQGEFTMTNNGHTVQIDLPPTMSITTG-DGTVYTAVQ 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692 115 FHLHWG--ISSGPGSEHTIDGEQYPMELHIVHMKQKYIRIEDALKDPSGVAVLGFFYEVSSTT-NRKYDLFAHALRSVQN 191
Cdd:cd03125    80 MHFHWGgrDSEISGSEHTIDGMRYVAELHIVHYNSKYKSYEEAKDKPDGLAVLAFLYKVGHYAeNTYYSDFISKLAKIKY 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692 192 TNGNTTLRKISLnQLILPEvNMTNYYRYDGSLTTPGCTEAVVWTVFEKPIPLDSEQLQAF-SSLKFRDGKPMVGTFRPVQ 270
Cdd:cd03125   160 AGQTTTLTSLDV-RDMLPE-NLHHYYTYQGSLTTPPCTENVLWFVFDDPVTLSKTQIVKLeNTLMDHHNKTIRNDYRRTQ 237

                  ....*..
gi 1379048692 271 PRNGRVV 277
Cdd:cd03125   238 PLNHRVV 244
alpha_CA_prokaryotic_like cd03124
Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are ...
36-279 1.06e-60

Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This sub-family includes bacterial carbonic anhydrase alpha, as well as plant enzymes such as tobacco nectarin III and yam dioscorin and, carbonic anhydrases from molluscs, such as nacrein, which are part of the organic matrix layer in shells. Other members of this family may be involved in maintaining pH balance, in facilitating transport of carbon dioxide or carbonic acid, or in sensing carbon dioxide levels in the environment. Dioscorin is the major storage protein of yam tubers and may play a role as an antioxidant. Tobacco Nectarin may play a role in the maintenace of pH and oxidative balance in nectar. Mollusc nacrein may participate in calcium carbonate crystal formation of the nacreous layer. This subfamily also includes three alpha carbonic anhydrases from Chlamydomonas reinhardtii (CAH 1-3). CAHs1-2 are localized in the periplasmic space. CAH1 faciliates the movement of carbon dioxide across the plasma membrane when the medium is alkaline. CAH3 is localized to the thylakoid lumen and provides CO2 to Rubisco.


Pssm-ID: 239398 [Multi-domain]  Cd Length: 216  Bit Score: 192.49  E-value: 1.06e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692  36 GPEKWREVNAD---CGK-DRQSPINIVTKQTKLDeRLTPFRFTGYQTVFdgTLKNNGHSVQVSIPVPA---TISGgnlaE 108
Cdd:cd03124     1 GPEHWGNLDPEfalCATgKNQSPIDITTKAVVSD-KLPPLNYNYKPTSA--TLVNNGHTIQVNFEGNGgtlTIDG----E 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692 109 PYKAVQFHLHwgissgPGSEHTIDGEQYPMELHIVHMKQKyiriedalkdpSGVAVLGFFYEVSsTTNRkydLFAHALRS 188
Cdd:cd03124    74 TYQLLQFHFH------SPSEHLINGKRYPLEAHLVHKSKD-----------GQLAVVAVLFEEG-KENP---FLKKILDN 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692 189 V-QNTNGNTTLRKIS-LNQLiLPEVNmtNYYRYDGSLTTPGCTEAVVWTVFEKPIPLDSEQLQAFSSLKFRdgkpmvGTF 266
Cdd:cd03124   133 MpKKEGTEVNLPAILdPNEL-LPESR--SYYRYEGSLTTPPCSEGVRWIVLKQPITISKEQLAKFRAAVYP------NNA 203
                         250
                  ....*....|...
gi 1379048692 267 RPVQPRNGRVVYR 279
Cdd:cd03124   204 RPVQPLNGREVLL 216
alpha_CA_XII_XIV cd03126
Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing ...
36-280 1.58e-58

Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the membrane proteins CA XII and XIV.


Pssm-ID: 239400  Cd Length: 249  Bit Score: 188.12  E-value: 1.58e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692  36 GPEKWREVNADCGKDRQSPINIVTKQTKLDERLTPFRFTGYQTVFDG--TLKNNGHSVQVSIPvpATISGGNLAEPYKAV 113
Cdd:cd03126     1 GENSWPKKYPFCGGVAQSPIDIHTDILQYDSSLPPLEFHGYNVSGTEqfTLTNNGHTVQLSLP--PTMHIGGLPFKYTAS 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692 114 QFHLHWGISSGP-GSEHTIDGEQYPMELHIVHM-KQKYIRIEDALKDPSGVAVLGFFYEVSSTtNRKYD-LFAHaLRSVQ 190
Cdd:cd03126    79 QLHLHWGQRGSPeGSEHTISGKHFAAELHIVHYnSDKYPDISTAMNKSQGLAVLGILIEVGPF-NPSYEkIFSH-LHEVK 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692 191 NTNGNTTLRKISLNQLiLPEvNMTNYYRYDGSLTTPGCTEAVVWTVFEKPIPLDSEQLQ----AFSSLKFRDGKPMVGTF 266
Cdd:cd03126   157 YKDQKVSVPGFNVQEL-LPK-RLDEYYRYEGSLTTPPCYPSVLWTVFRNPVQISQEQLLaletALYSTEEDESREMVNNY 234
                         250
                  ....*....|....
gi 1379048692 267 RPVQPRNGRVVYRS 280
Cdd:cd03126   235 RQVQPFNERLVFAS 248
alpha_CARP_receptor_like cd03122
Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related ...
36-278 6.44e-54

Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. This sub-family of carbonic anhydrase-related domains found in tyrosine phosphatase receptors may play a role in cell adhesion.


Pssm-ID: 239396 [Multi-domain]  Cd Length: 253  Bit Score: 176.39  E-value: 6.44e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692  36 GPEKWREVNADCGKDR-QSPINIVTKQTKLDERLTPFRFTGYQTVFDGT-LKNNGHSVQVSI---PVPATISGGNLAEPY 110
Cdd:cd03122     1 NPKHWAKKYPACGEGRqQSPIDIVEDTQVQRQGLQPLHFDGYEELTASTtLENTGKTVILRLegnSSDPFVSGGPLLGRY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692 111 KAVQFHLHWGISSGPGSEHTIDGEQYPMELHIVHMKQKYIRIEDALKDPSGVAVLGFFYEVSSTTNRKYDLFAHALRSVQ 190
Cdd:cd03122    81 KFSEITFHWGTCNSDGSEHSIDGHKFPLEMQILHRNTDFFDSFEAIKSPGGVLALAYLFELSHEDNPFLDPIIEGLRNVS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692 191 NTNGNTTLRKISLNQLiLPEvNMTNYYRYDGSLTTPGCTEAVVWTVFEKPIPLDSEQLQAFSSLKFRDGKP-MVGT---- 265
Cdd:cd03122   161 RPGKEVELPPFPLSDL-LPP-FTDKYYSYEGSLTTPPCSETVEWIVFREPVPISSRQLEAFRELLTRRQDGvMSGDylpn 238
                         250
                  ....*....|....
gi 1379048692 266 -FRPVQPRNGRVVY 278
Cdd:cd03122   239 nGRPQQPLGSRTVF 252
alpha_CA_VII cd03149
Carbonic anhydrase alpha, CA isozyme VII_like subgroup. Carbonic anhydrases (CAs) are ...
50-280 5.47e-52

Carbonic anhydrase alpha, CA isozyme VII_like subgroup. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This vertebrate subgroup comprises isozyme VII. CA VII is the most active cytosolic enzyme after CA II, and may be highly expressed in the brain. Human CA VII may be a target of antiepileptic sulfonamides/sulfamates.


Pssm-ID: 239402  Cd Length: 236  Bit Score: 170.79  E-value: 5.47e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692  50 DRQSPINIVTKQTKLDERLTPFRFTgYQTVFDGTLKNNGHSVQVS---IPVPATISGGNLAEPYKAVQFHLHWGISSGPG 126
Cdd:cd03149     2 NRQSPIDIVSSEAVYDPKLKPLSLS-YDPCTSLSISNNGHSVMVEfddSDDKTVITGGPLENPYRLKQFHFHWGAKHGSG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692 127 SEHTIDGEQYPMELHIVHMK-QKYIRIEDALKDPSGVAVLGFFYEVSStTNRKYDLFAHALRSVQNTNGNTTLRkiSLN- 204
Cdd:cd03149    81 SEHTVDGKTFPSELHLVHWNaKKYKSFGEAAAAPDGLAVLGVFLETGD-EHPGLNRLTDALYMVRFKGTKAQFL--DFNp 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692 205 QLILPevNMTNYYRYDGSLTTPGCTEAVVWTVFEKPIPLDSEQLQAFSSLKFRDGKP----MVGTFRPVQPRNGRVVYRS 280
Cdd:cd03149   158 KCLLP--KSLDYWTYPGSLTTPPLNESVTWIVLKEPIPVSEKQMGKFRELLFTSEEDqrnhMVNNFRPPQPLKGRTVRAS 235
alpha_CA_V cd03118
Carbonic anhydrase alpha, CA isozyme V_like subgroup. Carbonic anhydrases (CAs) are ...
50-280 1.18e-50

Carbonic anhydrase alpha, CA isozyme V_like subgroup. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This vertebrate subgroup comprises isozyme V. CA V is the mitochondrial isozyme, which may play a role in gluconeogenesis and ureagenesis and possibly also in lipogenesis.


Pssm-ID: 239392  Cd Length: 236  Bit Score: 167.33  E-value: 1.18e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692  50 DRQSPINIVTKQTKLDERLTPFRfTGYQTVFDGTLKNNGHSVQVSIPVPA---TISGGNLAEPYKAVQFHLHWGISSGPG 126
Cdd:cd03118     2 TRQSPINIQWRDSVYDPQLAPLR-VSYDPATCLYIWNNGYSFQVEFDDSTdksGISGGPLENHYRLKQFHFHWGANNEWG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692 127 SEHTIDGEQYPMELHIVHMKQ-KYIRIEDALKDPSGVAVLGFFYEVSStTNRKYDLFAHALRSVQNTNGNTTLRKISLNQ 205
Cdd:cd03118    81 SEHTVDGHTYPAELHLVHWNSvKYENFEEAVMEENGLAVIGVFLKLGA-HHEGLQKLVDALPEVRHKDTVVEFNPFDPSC 159
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1379048692 206 LiLPEVnmTNYYRYDGSLTTPGCTEAVVWTVFEKPIPLDSEQLQAFSSLKF----RDGKPMVGTFRPVQPRNGRVVYRS 280
Cdd:cd03118   160 L-LPAC--RDYWTYPGSLTTPPLTESVTWIIQKQPIEVSPSQLSVFRTLLFtsrgEEEKVMVNNFRPLQPLMNRKVRSS 235
alpha_CARP_X_XI_like cd03121
Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup ...
36-278 1.18e-49

Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. CARP XI plays a role in the development of gastrointestinal stromal tumors.


Pssm-ID: 239395 [Multi-domain]  Cd Length: 256  Bit Score: 165.28  E-value: 1.18e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692  36 GPEKWREVNAD---CGK-DRQSPINIVTKQTKLDERLTPFR-FTGYQTVfdGTLKNNGHSVQVSI-PVPAT-ISGGNLAE 108
Cdd:cd03121     1 GPSFWGLVNSAwnlCSKgRRQSPVDIEPSRLLFDPFLTPLRiDTGRKVS--GTFYNTGRHVSFRPdKDPVVnISGGPLSY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692 109 PYKAVQFHLHWGISSGPGSEHTIDGEQYPMELHIVHM-KQKYIRIEDALKDPSGVAVLGFFYEVSSTTN---RKYdLFAH 184
Cdd:cd03121    79 RYRLEEIRLHFGREDEQGSEHTVNGQAFPGEVQLIHYnSELYPNFSEASKSPNGLVIVSLFVKIGETSNpelRRL-TNRD 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692 185 ALRSVQNTNGNTTLRKISLnQLILPEVNmtNYYRYDGSLTTPGCTEAVVWTVFEKPIPLDSEQLQAFSSLKFRDGK---- 260
Cdd:cd03121   158 TITSIRYKGDAYFLQDLSI-ELLLPETD--HYITYEGSLTSPGCHETVTWIILNKPIYITKEQMHSLRLLSQNSPSqeka 234
                         250
                  ....*....|....*...
gi 1379048692 261 PMVGTFRPVQPRNGRVVY 278
Cdd:cd03121   235 PMSPNFRPVQPLNNRPVR 252
alpha_CARP_VIII cd03120
Carbonic anhydrase alpha related protein, group VIII. Carbonic anhydrase related proteins ...
42-281 7.19e-35

Carbonic anhydrase alpha related protein, group VIII. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. CARP VIII may play roles in various biological processes of the central nervous system, and could be involved in protein-protein interactions. CARP VIII has been shown to bind inositol 1,4,5-triphosphate (IP3) receptor type I (IP3RI), reducing the affinity of the receptor for IP3. IP3RI is an intracellular IP3-gated Ca2+ channel located on intracellular Ca2+ stores. IP3RI converts IP3 signaling into Ca2+ signaling thereby participating in a variety of cell functions.


Pssm-ID: 239394  Cd Length: 256  Bit Score: 126.89  E-value: 7.19e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692  42 EVNADCgkdrQSPINIVTKQTKLDERLTPFRFT-GYQTVFDGTLKNNGHSVQVSIPVPATISGGNLAEPYK----AVQFH 116
Cdd:cd03120    10 EANGEY----QSPINLNSREARYDPSLLEVRLSpNYVVCRDCEVINDGHTIQIILKSKSVLSGGPLPQGHEfelaEVRFH 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692 117 lhWGISSGPGSEHTIDGEQYPMELHIVHMKQK-YIRIEDALKDPSGVAVLGFFYEVSSTtNRKYDLFAHALRSVQNTNGN 195
Cdd:cd03120    86 --WGRENQRGSEHTVNFKAFPMELHLIHWNSTlYSSLEEAMGKPHGIAIIALFVQIGKE-HVGLKAVTEILQDIQYKGKS 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692 196 TTLRKISLNQLiLPEVNMTNYYRYDGSLTTPGCTEAVVWTVFEKPIPLDSEQLQAFSSLK--------FRDGKPMVG-TF 266
Cdd:cd03120   163 KTIPCFNPNTL-LPDPLLRDYWVYEGSLTTPPCSEGVTWILFRYPLTISQSQIEEFRRLRthvkgaelVEGCDGLLGdNF 241
                         250
                  ....*....|....*
gi 1379048692 267 RPVQPRNGRVVYRSS 281
Cdd:cd03120   242 RPTQPLSDRVIRAAF 256
PLN02179 PLN02179
carbonic anhydrase
35-239 1.16e-16

carbonic anhydrase


Pssm-ID: 177835  Cd Length: 235  Bit Score: 77.71  E-value: 1.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692  35 KGPEKWREVNAD---CGKDR-QSPINIVTKQTKL--DERLTpfrfTGYQTVFdGTLKNNGHSVQVSIPVPA---TISGGN 105
Cdd:PLN02179   45 KGPAEWGKLNPQwkvCSTGKyQSPIDLTDERVSLihDQALS----RHYKPAP-AVIQSRGHDVMVSWKGDAgkiTIHQTD 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692 106 laepYKAVQFHLHwgissGPgSEHTIDGEQYPMELHIVHMKQKyiriedalkdpSGVAVLGFFYEVSSTTNRKYDLFaHA 185
Cdd:PLN02179  120 ----YKLVQCHWH-----SP-SEHTINGTSYDLELHMVHTSAS-----------GKTAVVGVLYKLGEPDEFLTKLL-NG 177
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1379048692 186 LRSVQNTNGNTTL---RKISLnqlilpEVNmtNYYRYDGSLTTPGCTEAVVWTVFEK 239
Cdd:PLN02179  178 IKGVGKKEINLGIvdpRDIRF------ETN--NFYRYIGSLTIPPCTEGVIWTVVKR 226
PLN02202 PLN02202
carbonate dehydratase
36-277 1.38e-13

carbonate dehydratase


Pssm-ID: 177853 [Multi-domain]  Cd Length: 284  Bit Score: 69.70  E-value: 1.38e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692  36 GPEKWREVN---ADCGKDR-QSPINIVTKQTKLDERLTPFRFTGYQTvfDGTLKNNGHSVQVSIPVPAtisGGNLAEPYK 111
Cdd:PLN02202   38 GPNQWGHLNphfTKCAVGKlQSPIDIQRRQIFYNHKLESIHRDYYFT--NATLVNHVCNVAMFFGEGA---GDVIIDNKN 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692 112 AVQFHLHWGISSgpgsEHTIDGEQYPMELHIVHMKqkyiriedalKDPSGVAVLGFFY------EVSSTTNRKYDLFAHA 185
Cdd:PLN02202  113 YTLLQMHWHTPS----EHHLHGVQYAAELHMVHQA----------KDGSFAVVASLFKigteepFLSQMKDKLVKLKEER 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1379048692 186 LRSvqNTNGNTTLRKISLNQLilpEVNMTNYYRYDGSLTTPGCTEAVVWTVFEKPIPLDSEQLQAFSSlkfrdgkPMVGT 265
Cdd:PLN02202  179 FKG--NHTAQVEVGKIDTRHI---ERKTRKYFRYIGSLTTPPCSENVSWTILGKVRSMSKEQVELLRS-------PLDKS 246
                         250
                  ....*....|....*.
gi 1379048692 266 F----RPVQPRNGRVV 277
Cdd:PLN02202  247 FknnsRPCQPLNGRRV 262
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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