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Conserved domains on  [gi|166706885|ref|NP_001107611|]
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dematin isoform 3 [Homo sapiens]

Protein Classification

actin-binding LIM protein; villin family protein( domain architecture ID 11241350)

actin-binding LIM protein (abLIM) may act as a scaffold protein for signaling modules of the actin cytoskeleton| villin family protein similar to Oryza sativa villin-4, a Ca(2+)-regulated actin-binding protein involved in actin filament bundling, severing and capping

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AbLIM_anchor pfam16182
Putative adherens-junction anchoring region of AbLIM; AbLIM_anchor is a domain lying between ...
 7-308 6.63e-80

Putative adherens-junction anchoring region of AbLIM; AbLIM_anchor is a domain lying between the LIM actin-binding and the vilin-head domain of actin-binding LIM proteins. It is likely that this domain is involved in anchoring abLIMs to circumferential actin bundles in specific cell types.


:

Pssm-ID: 465046 [Multi-domain]  Cd Length: 319  Bit Score: 247.00  E-value: 6.63e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166706885    7 AKMDNQVLGYKDLAAIPKDKAILDIERPDLMIYEPHFTYSLLEhvELPRSRERSLSPKSTSPPPSP-----EVWADSRSP 81
Cdd:pfam16182  26 AKLDNEILDYKDLAALPKVKAIYDIERPDLISYEPYVSYSSDD--RLERQSYGESLSTLSPSSEDSydsreLRQRRSSSP 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166706885   82 GIISQASAPRTTGTPRTS--LPHFHHPET--------------------------------SRPDSNIYKKPPIYKQRES 127
Cdd:pfam16182 104 GSIGSPTYSRHGYTPTLSrsPQHFHRPGSesgrsspslsqpsdrkspptyvqapkhfhvpdTGVKDNIYRKPPIYKQHGT 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166706885  128 VGGSPQTkhliEDLIIESSKFPAAqppdpnqpakietdywpcppslAVVETEWRkrkasrrgaeeeeeeedddsgeemka 207
Cdd:pfam16182 184 SASASQS----SEDIIHSSRFPAS----------------------GGEEEGWN-------------------------- 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166706885  208 LRERQREELSKVTSNLGKMILKEEME-KSLPIRRKTRSLPDRTPFHTSL-HQGTSKSSSLPAYGRTTLSRLQSTEFSPSG 285
Cdd:pfam16182 212 RRLLQEEELSKIQSGLGKLILKEEMEaRSGSERRDPWSSPRSSPSGSSGsDSPYSKSASLPGYGRNGLHRPQSADFFQYG 291

                         330       340
                  ....*....|....*....|....*...
gi 166706885  286 SETGSPG-----LQIYPYEMLVVTNKGR 308
Cdd:pfam16182 292 SDGDVSWggmreYKIYPYEMLAVTNRGR 319
VHP smart00153
Villin headpiece domain;
323-358 3.45e-14

Villin headpiece domain;


:

Pssm-ID: 128458  Cd Length: 36  Bit Score: 65.80  E-value: 3.45e-14
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 166706885   323 HLSAEDFSRVFAMSPEEFGKLALWKRNELKKKASLF 358
Cdd:smart00153   1 YLSDEDFEEVFGMTREEFYKLPLWKQNQLKKKKGLF 36
 
Name Accession Description Interval E-value
AbLIM_anchor pfam16182
Putative adherens-junction anchoring region of AbLIM; AbLIM_anchor is a domain lying between ...
 7-308 6.63e-80

Putative adherens-junction anchoring region of AbLIM; AbLIM_anchor is a domain lying between the LIM actin-binding and the vilin-head domain of actin-binding LIM proteins. It is likely that this domain is involved in anchoring abLIMs to circumferential actin bundles in specific cell types.


Pssm-ID: 465046 [Multi-domain]  Cd Length: 319  Bit Score: 247.00  E-value: 6.63e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166706885    7 AKMDNQVLGYKDLAAIPKDKAILDIERPDLMIYEPHFTYSLLEhvELPRSRERSLSPKSTSPPPSP-----EVWADSRSP 81
Cdd:pfam16182  26 AKLDNEILDYKDLAALPKVKAIYDIERPDLISYEPYVSYSSDD--RLERQSYGESLSTLSPSSEDSydsreLRQRRSSSP 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166706885   82 GIISQASAPRTTGTPRTS--LPHFHHPET--------------------------------SRPDSNIYKKPPIYKQRES 127
Cdd:pfam16182 104 GSIGSPTYSRHGYTPTLSrsPQHFHRPGSesgrsspslsqpsdrkspptyvqapkhfhvpdTGVKDNIYRKPPIYKQHGT 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166706885  128 VGGSPQTkhliEDLIIESSKFPAAqppdpnqpakietdywpcppslAVVETEWRkrkasrrgaeeeeeeedddsgeemka 207
Cdd:pfam16182 184 SASASQS----SEDIIHSSRFPAS----------------------GGEEEGWN-------------------------- 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166706885  208 LRERQREELSKVTSNLGKMILKEEME-KSLPIRRKTRSLPDRTPFHTSL-HQGTSKSSSLPAYGRTTLSRLQSTEFSPSG 285
Cdd:pfam16182 212 RRLLQEEELSKIQSGLGKLILKEEMEaRSGSERRDPWSSPRSSPSGSSGsDSPYSKSASLPGYGRNGLHRPQSADFFQYG 291

                         330       340
                  ....*....|....*....|....*...
gi 166706885  286 SETGSPG-----LQIYPYEMLVVTNKGR 308
Cdd:pfam16182 292 SDGDVSWggmreYKIYPYEMLAVTNRGR 319
VHP smart00153
Villin headpiece domain;
323-358 3.45e-14

Villin headpiece domain;


Pssm-ID: 128458  Cd Length: 36  Bit Score: 65.80  E-value: 3.45e-14
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 166706885   323 HLSAEDFSRVFAMSPEEFGKLALWKRNELKKKASLF 358
Cdd:smart00153   1 YLSDEDFEEVFGMTREEFYKLPLWKQNQLKKKKGLF 36
VHP pfam02209
Villin headpiece domain;
323-358 1.54e-12

Villin headpiece domain;


Pssm-ID: 460493  Cd Length: 36  Bit Score: 61.24  E-value: 1.54e-12
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 166706885  323 HLSAEDFSRVFAMSPEEFGKLALWKRNELKKKASLF 358
Cdd:pfam02209   1 YLSDEDFEEVFGMSREEFYKLPKWKQNNLKKKAGLF 36
 
Name Accession Description Interval E-value
AbLIM_anchor pfam16182
Putative adherens-junction anchoring region of AbLIM; AbLIM_anchor is a domain lying between ...
 7-308 6.63e-80

Putative adherens-junction anchoring region of AbLIM; AbLIM_anchor is a domain lying between the LIM actin-binding and the vilin-head domain of actin-binding LIM proteins. It is likely that this domain is involved in anchoring abLIMs to circumferential actin bundles in specific cell types.


Pssm-ID: 465046 [Multi-domain]  Cd Length: 319  Bit Score: 247.00  E-value: 6.63e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166706885    7 AKMDNQVLGYKDLAAIPKDKAILDIERPDLMIYEPHFTYSLLEhvELPRSRERSLSPKSTSPPPSP-----EVWADSRSP 81
Cdd:pfam16182  26 AKLDNEILDYKDLAALPKVKAIYDIERPDLISYEPYVSYSSDD--RLERQSYGESLSTLSPSSEDSydsreLRQRRSSSP 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166706885   82 GIISQASAPRTTGTPRTS--LPHFHHPET--------------------------------SRPDSNIYKKPPIYKQRES 127
Cdd:pfam16182 104 GSIGSPTYSRHGYTPTLSrsPQHFHRPGSesgrsspslsqpsdrkspptyvqapkhfhvpdTGVKDNIYRKPPIYKQHGT 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166706885  128 VGGSPQTkhliEDLIIESSKFPAAqppdpnqpakietdywpcppslAVVETEWRkrkasrrgaeeeeeeedddsgeemka 207
Cdd:pfam16182 184 SASASQS----SEDIIHSSRFPAS----------------------GGEEEGWN-------------------------- 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 166706885  208 LRERQREELSKVTSNLGKMILKEEME-KSLPIRRKTRSLPDRTPFHTSL-HQGTSKSSSLPAYGRTTLSRLQSTEFSPSG 285
Cdd:pfam16182 212 RRLLQEEELSKIQSGLGKLILKEEMEaRSGSERRDPWSSPRSSPSGSSGsDSPYSKSASLPGYGRNGLHRPQSADFFQYG 291

                         330       340
                  ....*....|....*....|....*...
gi 166706885  286 SETGSPG-----LQIYPYEMLVVTNKGR 308
Cdd:pfam16182 292 SDGDVSWggmreYKIYPYEMLAVTNRGR 319
VHP smart00153
Villin headpiece domain;
323-358 3.45e-14

Villin headpiece domain;


Pssm-ID: 128458  Cd Length: 36  Bit Score: 65.80  E-value: 3.45e-14
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 166706885   323 HLSAEDFSRVFAMSPEEFGKLALWKRNELKKKASLF 358
Cdd:smart00153   1 YLSDEDFEEVFGMTREEFYKLPLWKQNQLKKKKGLF 36
VHP pfam02209
Villin headpiece domain;
323-358 1.54e-12

Villin headpiece domain;


Pssm-ID: 460493  Cd Length: 36  Bit Score: 61.24  E-value: 1.54e-12
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 166706885  323 HLSAEDFSRVFAMSPEEFGKLALWKRNELKKKASLF 358
Cdd:pfam02209   1 YLSDEDFEEVFGMSREEFYKLPKWKQNNLKKKAGLF 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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