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Conserved domains on  [gi|164663816|ref|NP_001106878|]
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LIM domain-binding protein 1 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LIM_bind pfam01803
LIM-domain binding protein; The LIM-domain binding protein, binds to the LIM domain pfam00412 ...
 70-271 7.50e-28

LIM-domain binding protein; The LIM-domain binding protein, binds to the LIM domain pfam00412 of LIM homeodomain proteins which are transcriptional regulators of development. Nuclear LIM interactor (NLI) / LIM domain-binding protein 1 (LDB1) is located in the nuclei of neuronal cells during development, it is co-expressed with Isl1 in early motor neuron differentiation and has a suggested role in the Isl1 dependent development of motor neurons. It is suggested that these proteins act synergistically to enhance transcriptional efficiency by acting as co-factors for LIM homeodomain and Otx class transcription factors both of which have essential roles in development. The Drosophila protein Chip is required for segmentation and activity of a remote wing margin enhancer. Chip is a ubiquitous chromosomal factor required for normal expression of diverse genes at many stages of development. It is suggested that Chip cooperates with different LIM domain proteins and other factors to structurally support remote enhancer-promoter interactions.


:

Pssm-ID: 426444  Cd Length: 242  Bit Score: 110.06  E-value: 7.50e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663816   70 RIFELNKRLQNWTEECDNL-WWDAFTTEFFEDDAMLTITFCL----EDGPKRYTIGRTLIPRYFRSIFEGGATELYYVLK 144
Cdd:pfam01803   1 RLLQFIEHLSNFSKNLNDIeYWQKFVAEFFSPTGVLRHSLKSydcgGKEPKQFEITTPALPRYFVTLFDSGVKRIQLILD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663816  145 HPKEAFHSNF-VSLDCDQGSMVT--QHGkpmfTQVCVEGRLYLefMFDDMMRIKTWHFSIRQHRELIPRSILAMHA---- 217
Cdd:pfam01803  81 GAREQVLSNGsIFVECPKASFTYwyEDG----SQVVLTGQLRA--LFDADLKIEWLEFCTRSHEEYIPRNSLEKLLkqlh 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663816  218 --------------------------------QDPQMLDQL-SKNITRCGLSNSTLNYLRLCVILEPMQELMS-RHKTYS 263
Cdd:pfam01803 155 ewadlsqspkmskkvlqkqqifqalsskspapEPPEAIKELpSSFVNDFGIPEAVMRFLQIGEVMSSMKDLMEfSKQNNI 234


                  ....*...
gi 164663816  264 LSPRDCLK 271
Cdd:pfam01803 235 LSPLEALE 242
LID pfam17916
LIM interaction domain (LID); LIM-homeodomain (LIM-HD) proteins are transcription factors that ...
 336-364 6.17e-09

LIM interaction domain (LID); LIM-homeodomain (LIM-HD) proteins are transcription factors that are critical in the development of many cell types and tissues. The activity of LIM-HD proteins is dependent on the essential cofactor LIM domain-binding protein 1 (Ldb1). This entry represents a 30-residue LIM interaction domain (LID) that binds to the LIM domains of all LIM-HD and closely related LIM-only (LMO) proteins. Isl1 (Insulin gene enhancer protein 1) and Isl2 each contain a LID-like sequence in their C-terminal regions, the Lhx3-binding domain (LBD), which binds the LIM domains Lhx3 and Lhx4.


:

Pssm-ID: 465564  Cd Length: 29  Bit Score: 51.32  E-value: 6.17e-09
                          10        20
                  ....*....|....*....|....*....
gi 164663816  336 DVMVVGEPTLMGGEFGDEDERLITRLENT 364
Cdd:pfam17916   1 DVMVVGEPSMMGSDFGEGDERTISRVENT 29
 
Name Accession Description Interval E-value
LIM_bind pfam01803
LIM-domain binding protein; The LIM-domain binding protein, binds to the LIM domain pfam00412 ...
 70-271 7.50e-28

LIM-domain binding protein; The LIM-domain binding protein, binds to the LIM domain pfam00412 of LIM homeodomain proteins which are transcriptional regulators of development. Nuclear LIM interactor (NLI) / LIM domain-binding protein 1 (LDB1) is located in the nuclei of neuronal cells during development, it is co-expressed with Isl1 in early motor neuron differentiation and has a suggested role in the Isl1 dependent development of motor neurons. It is suggested that these proteins act synergistically to enhance transcriptional efficiency by acting as co-factors for LIM homeodomain and Otx class transcription factors both of which have essential roles in development. The Drosophila protein Chip is required for segmentation and activity of a remote wing margin enhancer. Chip is a ubiquitous chromosomal factor required for normal expression of diverse genes at many stages of development. It is suggested that Chip cooperates with different LIM domain proteins and other factors to structurally support remote enhancer-promoter interactions.


Pssm-ID: 426444  Cd Length: 242  Bit Score: 110.06  E-value: 7.50e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663816   70 RIFELNKRLQNWTEECDNL-WWDAFTTEFFEDDAMLTITFCL----EDGPKRYTIGRTLIPRYFRSIFEGGATELYYVLK 144
Cdd:pfam01803   1 RLLQFIEHLSNFSKNLNDIeYWQKFVAEFFSPTGVLRHSLKSydcgGKEPKQFEITTPALPRYFVTLFDSGVKRIQLILD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663816  145 HPKEAFHSNF-VSLDCDQGSMVT--QHGkpmfTQVCVEGRLYLefMFDDMMRIKTWHFSIRQHRELIPRSILAMHA---- 217
Cdd:pfam01803  81 GAREQVLSNGsIFVECPKASFTYwyEDG----SQVVLTGQLRA--LFDADLKIEWLEFCTRSHEEYIPRNSLEKLLkqlh 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663816  218 --------------------------------QDPQMLDQL-SKNITRCGLSNSTLNYLRLCVILEPMQELMS-RHKTYS 263
Cdd:pfam01803 155 ewadlsqspkmskkvlqkqqifqalsskspapEPPEAIKELpSSFVNDFGIPEAVMRFLQIGEVMSSMKDLMEfSKQNNI 234


                  ....*...
gi 164663816  264 LSPRDCLK 271
Cdd:pfam01803 235 LSPLEALE 242
LID pfam17916
LIM interaction domain (LID); LIM-homeodomain (LIM-HD) proteins are transcription factors that ...
 336-364 6.17e-09

LIM interaction domain (LID); LIM-homeodomain (LIM-HD) proteins are transcription factors that are critical in the development of many cell types and tissues. The activity of LIM-HD proteins is dependent on the essential cofactor LIM domain-binding protein 1 (Ldb1). This entry represents a 30-residue LIM interaction domain (LID) that binds to the LIM domains of all LIM-HD and closely related LIM-only (LMO) proteins. Isl1 (Insulin gene enhancer protein 1) and Isl2 each contain a LID-like sequence in their C-terminal regions, the Lhx3-binding domain (LBD), which binds the LIM domains Lhx3 and Lhx4.


Pssm-ID: 465564  Cd Length: 29  Bit Score: 51.32  E-value: 6.17e-09
                          10        20
                  ....*....|....*....|....*....
gi 164663816  336 DVMVVGEPTLMGGEFGDEDERLITRLENT 364
Cdd:pfam17916   1 DVMVVGEPSMMGSDFGEGDERTISRVENT 29
 
Name Accession Description Interval E-value
LIM_bind pfam01803
LIM-domain binding protein; The LIM-domain binding protein, binds to the LIM domain pfam00412 ...
 70-271 7.50e-28

LIM-domain binding protein; The LIM-domain binding protein, binds to the LIM domain pfam00412 of LIM homeodomain proteins which are transcriptional regulators of development. Nuclear LIM interactor (NLI) / LIM domain-binding protein 1 (LDB1) is located in the nuclei of neuronal cells during development, it is co-expressed with Isl1 in early motor neuron differentiation and has a suggested role in the Isl1 dependent development of motor neurons. It is suggested that these proteins act synergistically to enhance transcriptional efficiency by acting as co-factors for LIM homeodomain and Otx class transcription factors both of which have essential roles in development. The Drosophila protein Chip is required for segmentation and activity of a remote wing margin enhancer. Chip is a ubiquitous chromosomal factor required for normal expression of diverse genes at many stages of development. It is suggested that Chip cooperates with different LIM domain proteins and other factors to structurally support remote enhancer-promoter interactions.


Pssm-ID: 426444  Cd Length: 242  Bit Score: 110.06  E-value: 7.50e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663816   70 RIFELNKRLQNWTEECDNL-WWDAFTTEFFEDDAMLTITFCL----EDGPKRYTIGRTLIPRYFRSIFEGGATELYYVLK 144
Cdd:pfam01803   1 RLLQFIEHLSNFSKNLNDIeYWQKFVAEFFSPTGVLRHSLKSydcgGKEPKQFEITTPALPRYFVTLFDSGVKRIQLILD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663816  145 HPKEAFHSNF-VSLDCDQGSMVT--QHGkpmfTQVCVEGRLYLefMFDDMMRIKTWHFSIRQHRELIPRSILAMHA---- 217
Cdd:pfam01803  81 GAREQVLSNGsIFVECPKASFTYwyEDG----SQVVLTGQLRA--LFDADLKIEWLEFCTRSHEEYIPRNSLEKLLkqlh 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164663816  218 --------------------------------QDPQMLDQL-SKNITRCGLSNSTLNYLRLCVILEPMQELMS-RHKTYS 263
Cdd:pfam01803 155 ewadlsqspkmskkvlqkqqifqalsskspapEPPEAIKELpSSFVNDFGIPEAVMRFLQIGEVMSSMKDLMEfSKQNNI 234


                  ....*...
gi 164663816  264 LSPRDCLK 271
Cdd:pfam01803 235 LSPLEALE 242
LID pfam17916
LIM interaction domain (LID); LIM-homeodomain (LIM-HD) proteins are transcription factors that ...
 336-364 6.17e-09

LIM interaction domain (LID); LIM-homeodomain (LIM-HD) proteins are transcription factors that are critical in the development of many cell types and tissues. The activity of LIM-HD proteins is dependent on the essential cofactor LIM domain-binding protein 1 (Ldb1). This entry represents a 30-residue LIM interaction domain (LID) that binds to the LIM domains of all LIM-HD and closely related LIM-only (LMO) proteins. Isl1 (Insulin gene enhancer protein 1) and Isl2 each contain a LID-like sequence in their C-terminal regions, the Lhx3-binding domain (LBD), which binds the LIM domains Lhx3 and Lhx4.


Pssm-ID: 465564  Cd Length: 29  Bit Score: 51.32  E-value: 6.17e-09
                          10        20
                  ....*....|....*....|....*....
gi 164663816  336 DVMVVGEPTLMGGEFGDEDERLITRLENT 364
Cdd:pfam17916   1 DVMVVGEPSMMGSDFGEGDERTISRVENT 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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