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Conserved domains on  [gi|189217925|ref|NP_001103147|]
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uncharacterized protein LOC100125361 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-43 1.59e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.14  E-value: 1.59e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 189217925    3 SVAFDDVAINFTQEEWALLDPSQKSLYRDVMEEVFRNLTSI 43
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
139-299 1.10e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217925 139 KPYECKQCGKAFSHSSSFRKHERT--HTGE--RPYVC--KQCGKAFNCSGSIRKHERTHTGEKPYECK--QCGKAFN--- 207
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSpll 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217925 208 ---CPSYLQIHERSHTgEKPYEC--KQCGKTFSCSSSLRKHERTHTGEKPYECK--QCGKAFSCSSSFRKHERTHTGERP 280
Cdd:COG5048  368 nnePPQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAP 446

                        170
                 ....*....|....*....
gi 189217925 281 YECKQCGKAFFSLTSVRTH 299
Cdd:COG5048  447 LLCSILKSFRRDLDLSNHG 465
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
223-382 1.27e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217925 223 KPYECKQCGKTFSCSSSLRKHERT--HTGE--KPYEC--KQCGKAFSCSSSFRKHERTHTGERPYECK------------ 284
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllnssskfspll 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217925 285 -QCGKAFFSLTSVRTHMIKHTGNGPFKCSVCEEvfpfSSVFRRHQTSHAGEKLYECK--QCNKWFSSSTSLHNHERSHNG 361
Cdd:COG5048  368 nNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKR----DSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTN 443

                        170       180
                 ....*....|....*....|.
gi 189217925 362 EKPYTCKPRGKAFIRKHERAH 382
Cdd:COG5048  444 HAPLLCSILKSFRRDLDLSNH 464
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-43 1.59e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.14  E-value: 1.59e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 189217925    3 SVAFDDVAINFTQEEWALLDPSQKSLYRDVMEEVFRNLTSI 43
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
4-44 1.13e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 79.56  E-value: 1.13e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 189217925     4 VAFDDVAINFTQEEWALLDPSQKSLYRDVMEEVFRNLTSIE 44
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 2.05e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 75.28  E-value: 2.05e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 189217925   4 VAFDDVAINFTQEEWALLDPSQKSLYRDVMEEVFRNLTSI 43
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
139-299 1.10e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217925 139 KPYECKQCGKAFSHSSSFRKHERT--HTGE--RPYVC--KQCGKAFNCSGSIRKHERTHTGEKPYECK--QCGKAFN--- 207
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSpll 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217925 208 ---CPSYLQIHERSHTgEKPYEC--KQCGKTFSCSSSLRKHERTHTGEKPYECK--QCGKAFSCSSSFRKHERTHTGERP 280
Cdd:COG5048  368 nnePPQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAP 446

                        170
                 ....*....|....*....
gi 189217925 281 YECKQCGKAFFSLTSVRTH 299
Cdd:COG5048  447 LLCSILKSFRRDLDLSNHG 465
zf-H2C2_2 pfam13465
Zinc-finger double domain;
239-264 5.23e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 5.23e-05
                          10        20
                  ....*....|....*....|....*.
gi 189217925  239 SLRKHERTHTGEKPYECKQCGKAFSC 264
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
223-382 1.27e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217925 223 KPYECKQCGKTFSCSSSLRKHERT--HTGE--KPYEC--KQCGKAFSCSSSFRKHERTHTGERPYECK------------ 284
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllnssskfspll 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217925 285 -QCGKAFFSLTSVRTHMIKHTGNGPFKCSVCEEvfpfSSVFRRHQTSHAGEKLYECK--QCNKWFSSSTSLHNHERSHNG 361
Cdd:COG5048  368 nNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKR----DSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTN 443

                        170       180
                 ....*....|....*....|.
gi 189217925 362 EKPYTCKPRGKAFIRKHERAH 382
Cdd:COG5048  444 HAPLLCSILKSFRRDLDLSNH 464
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-43 1.59e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.14  E-value: 1.59e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 189217925    3 SVAFDDVAINFTQEEWALLDPSQKSLYRDVMEEVFRNLTSI 43
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
4-44 1.13e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 79.56  E-value: 1.13e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 189217925     4 VAFDDVAINFTQEEWALLDPSQKSLYRDVMEEVFRNLTSIE 44
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 2.05e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 75.28  E-value: 2.05e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 189217925   4 VAFDDVAINFTQEEWALLDPSQKSLYRDVMEEVFRNLTSI 43
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
139-299 1.10e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217925 139 KPYECKQCGKAFSHSSSFRKHERT--HTGE--RPYVC--KQCGKAFNCSGSIRKHERTHTGEKPYECK--QCGKAFN--- 207
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSpll 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217925 208 ---CPSYLQIHERSHTgEKPYEC--KQCGKTFSCSSSLRKHERTHTGEKPYECK--QCGKAFSCSSSFRKHERTHTGERP 280
Cdd:COG5048  368 nnePPQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAP 446

                        170
                 ....*....|....*....
gi 189217925 281 YECKQCGKAFFSLTSVRTH 299
Cdd:COG5048  447 LLCSILKSFRRDLDLSNHG 465
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
111-418 2.86e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 2.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217925 111 KPYKCMLCGKAFHFPSEFRIHLRTHTGEKPYEC--KQCGKAFSHSSSFRKHERTHTGERPYVCKQCGKAFNCSGSIRKHE 188
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217925 189 RTHTGE-KPYECKQCGKAFNCPSYLQIHERSHTGEKPYECKQC-GKTFSCSSSLRKHERTHTGEKPyeckqcgKAFSCSS 266
Cdd:COG5048  112 SSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLS-------KDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217925 267 SFRKHERTHTGERPYECKQCGKAFFSLTSVRTHMIKHTGNGPFKCSVCEEVFPFSSVFRRHQ------TSHAGEKLYECK 340
Cdd:COG5048  185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSslsssdSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217925 341 QCNKWFSSSTSLHNHERSHNG-EKPYTCKPRGKAFIRKH-------ERAHAGGKSYPCKQ----CGEWFSASSSLQMHGR 408
Cdd:COG5048  265 LPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSpltrhlrSVNHSGESLKPFSCpyslCGKLFSRNDALKRHIL 344

                        330
                 ....*....|
gi 189217925 409 IQTGEKPHKC 418
Cdd:COG5048  345 LHTSISPAKE 354
zf-H2C2_2 pfam13465
Zinc-finger double domain;
239-264 5.23e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 5.23e-05
                          10        20
                  ....*....|....*....|....*.
gi 189217925  239 SLRKHERTHTGEKPYECKQCGKAFSC 264
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
185-208 2.61e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.61e-04
                          10        20
                  ....*....|....*....|....
gi 189217925  185 RKHERTHTGEKPYECKQCGKAFNC 208
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
59-272 2.62e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 2.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217925  59 PETNLRHIIANSGCNLYESEEHSEKPYKFTQYRNSfISLMSIQRHMIMDTG-SKPYKCMLCGKAFHFPSEFRIHLRT--H 135
Cdd:COG5048  236 SPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS-QSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnH 314

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217925 136 TGE--KPYEC--KQCGKAFSHSSSFRKHERTHTGERPYVCK--QCGKAFNCSGSIRKHERTH-----TGEKPYEC--KQC 202
Cdd:COG5048  315 SGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSC 394

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 189217925 203 GKAFNCPSYLQIHERSHTGEKPYECK--QCGKTFSCSSSLRKHERTHTGEKPYECKQCGKAFSCSSSFRKHE 272
Cdd:COG5048  395 IRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
211-236 3.18e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.18e-04
                          10        20
                  ....*....|....*....|....*.
gi 189217925  211 YLQIHERSHTGEKPYECKQCGKTFSC 236
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
127-152 3.94e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.94e-04
                          10        20
                  ....*....|....*....|....*.
gi 189217925  127 EFRIHLRTHTGEKPYECKQCGKAFSH 152
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
155-180 5.78e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 5.78e-04
                          10        20
                  ....*....|....*....|....*.
gi 189217925  155 SFRKHERTHTGERPYVCKQCGKAFNC 180
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
267-290 8.23e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.23e-04
                          10        20
                  ....*....|....*....|....
gi 189217925  267 SFRKHERTHTGERPYECKQCGKAF 290
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
195-353 9.50e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 9.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217925 195 KPYECKQCGKAFNCPSYLQIHERS--HTGE--KPYEC--KQCGKTFSCSSSLRKHERTHTGEKPYECKQC-------GKA 261
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217925 262 FSCSSSFRKHERTHTGERPYEC--KQCGKAFFSLTSVRTHMIKHTGNGP--FKCSVCEEVFPFSSVFRRHQTSHageKLY 337
Cdd:COG5048  368 NNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIH---TNH 444

                        170
                 ....*....|....*.
gi 189217925 338 ECKQCNKWFSSSTSLH 353
Cdd:COG5048  445 APLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
223-382 1.27e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217925 223 KPYECKQCGKTFSCSSSLRKHERT--HTGE--KPYEC--KQCGKAFSCSSSFRKHERTHTGERPYECK------------ 284
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllnssskfspll 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189217925 285 -QCGKAFFSLTSVRTHMIKHTGNGPFKCSVCEEvfpfSSVFRRHQTSHAGEKLYECK--QCNKWFSSSTSLHNHERSHNG 361
Cdd:COG5048  368 nNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKR----DSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTN 443

                        170       180
                 ....*....|....*....|.
gi 189217925 362 EKPYTCKPRGKAFIRKHERAH 382
Cdd:COG5048  444 HAPLLCSILKSFRRDLDLSNH 464
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 141-163 5.30e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 5.30e-03
                          10        20
                  ....*....|....*....|...
gi 189217925  141 YECKQCGKAFSHSSSFRKHERTH 163
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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