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Conserved domains on  [gi|157823942|ref|NP_001102973|]
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COMM domain-containing protein 2 [Rattus norvegicus]

Protein Classification

COMM domain-containing protein 2( domain architecture ID 10140827)

COMM domain-containing protein 2 (COMMD2) may modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes and may also down-regulate activation of NF-kappa-B

Gene Symbol:  COMMD2
Gene Ontology:  GO:0005515
PubMed:  15799966
SCOP:  4005215

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Commd2 cd04750
COMM_Domain containing protein 2. The COMM Domain is found at the C-terminus of a variety of ...
 26-190 5.99e-80

COMM_Domain containing protein 2. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


:

Pssm-ID: 240098 [Multi-domain]  Cd Length: 166  Bit Score: 235.29  E-value: 5.99e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823942  26 EFGRIAVEFLRRGSNPKIYEGAARKLNVSSDTIQHGVEGLTYLLTESSKLMISELDFQDSVFVLGFSEELNKLLLQLYLD 105
Cdd:cd04750    1 EFCKLAIEFLFKGINQKKYEGAARKLEVEVETVQHGVEALVYLLIESTKLKLSERDFQDSIEFLGFSDDLNEILLQLYES 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823942 106 NRKEIRTILNELAPRLPSYHSLEWRLDVQLASRSLRQQMKPAVTIKLHLDQSGDH-STHCLQTDPATLLHLVQQLEQALE 184
Cdd:cd04750   81 NRKEIRNILKELSPDLPHYHNLEWRLDVQIASRSLRSQVKPVITMKLHLEDENKKiETHLLQTDPANLVHLTQTLEQALQ 160


                 ....*.
gi 157823942 185 EMKTNH 190
Cdd:cd04750  161 ESKTLH 166
 
Name Accession Description Interval E-value
Commd2 cd04750
COMM_Domain containing protein 2. The COMM Domain is found at the C-terminus of a variety of ...
 26-190 5.99e-80

COMM_Domain containing protein 2. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240098 [Multi-domain]  Cd Length: 166  Bit Score: 235.29  E-value: 5.99e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823942  26 EFGRIAVEFLRRGSNPKIYEGAARKLNVSSDTIQHGVEGLTYLLTESSKLMISELDFQDSVFVLGFSEELNKLLLQLYLD 105
Cdd:cd04750    1 EFCKLAIEFLFKGINQKKYEGAARKLEVEVETVQHGVEALVYLLIESTKLKLSERDFQDSIEFLGFSDDLNEILLQLYES 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823942 106 NRKEIRTILNELAPRLPSYHSLEWRLDVQLASRSLRQQMKPAVTIKLHLDQSGDH-STHCLQTDPATLLHLVQQLEQALE 184
Cdd:cd04750   81 NRKEIRNILKELSPDLPHYHNLEWRLDVQIASRSLRSQVKPVITMKLHLEDENKKiETHLLQTDPANLVHLTQTLEQALQ 160


                 ....*.
gi 157823942 185 EMKTNH 190
Cdd:cd04750  161 ESKTLH 166
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 120-182 1.17e-14

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 65.65  E-value: 1.17e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157823942  120 RLPSYHSLEWRLDVQLASRSLRQQMKPAVTIKLHL-DQSGDHSTHCLQTDPATLLHLVQQLEQA 182
Cdd:pfam07258   1 SLPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLsDGDGSSEEVTFELSKEQLQDLLNELEEA 64
 
Name Accession Description Interval E-value
Commd2 cd04750
COMM_Domain containing protein 2. The COMM Domain is found at the C-terminus of a variety of ...
 26-190 5.99e-80

COMM_Domain containing protein 2. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240098 [Multi-domain]  Cd Length: 166  Bit Score: 235.29  E-value: 5.99e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823942  26 EFGRIAVEFLRRGSNPKIYEGAARKLNVSSDTIQHGVEGLTYLLTESSKLMISELDFQDSVFVLGFSEELNKLLLQLYLD 105
Cdd:cd04750    1 EFCKLAIEFLFKGINQKKYEGAARKLEVEVETVQHGVEALVYLLIESTKLKLSERDFQDSIEFLGFSDDLNEILLQLYES 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823942 106 NRKEIRTILNELAPRLPSYHSLEWRLDVQLASRSLRQQMKPAVTIKLHLDQSGDH-STHCLQTDPATLLHLVQQLEQALE 184
Cdd:cd04750   81 NRKEIRNILKELSPDLPHYHNLEWRLDVQIASRSLRSQVKPVITMKLHLEDENKKiETHLLQTDPANLVHLTQTLEQALQ 160


                 ....*.
gi 157823942 185 EMKTNH 190
Cdd:cd04750  161 ESKTLH 166
Commd cd04748
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene ...
 105-186 3.27e-16

COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. HCaRG, a nuclear protein that might be involved in cell proliferation, is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals.


Pssm-ID: 240096  Cd Length: 87  Bit Score: 70.42  E-value: 3.27e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823942 105 DNRKEIRTILNELAPRLPSYHSLEWRLDVQLASRSLRQQMKPAVTIKLHLdQSGDH---STHCLQTDPATLLHLVQQLEQ 181
Cdd:cd04748    4 ENKAEIEELLSKQSLSLPQLVDFDWRLDVQISSSSLAKVKQPTILVQLKL-QVGDNnssEKICFEMTKEELQNFLNKLKK 82


                 ....*
gi 157823942 182 ALEEM 186
Cdd:cd04748   83 IKAQL 87
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 120-182 1.17e-14

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 65.65  E-value: 1.17e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157823942  120 RLPSYHSLEWRLDVQLASRSLRQQMKPAVTIKLHL-DQSGDHSTHCLQTDPATLLHLVQQLEQA 182
Cdd:pfam07258   1 SLPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLsDGDGSSEEVTFELSKEQLQDLLNELEEA 64
Commd4 cd04752
COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of ...
 42-188 2.56e-06

COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240100 [Multi-domain]  Cd Length: 174  Bit Score: 45.88  E-value: 2.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823942  42 KIYEGAARKLNVSSDtIQHGVEGLTYLLTESSKLMISELDFQDSVFVLGFSEELNKLLLQLYLDNRKEIRTILNELAPRL 121
Cdd:cd04752   26 KVLKLTADAKFESGD-VKASIAVLSFILSSAAKYNVDGESLSSELQQLGLPKEHATSLCRSYEEKQSKLQESLRANSLRL 104

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157823942 122 PSYHSLEWRLDVQLASRSLRQQMKPAVTIKLHLDqsgDHSTHCLQTDPATLLH-----LVQQLEQALEEMKT 188
Cdd:cd04752  105 SRLESVDWRVDYILSSSELQEVNEPLVQLRLKVR---NADTGEITPHPFSVSAdkfrvLLAELKQAQTLMET 173
Commd1_MURR1 cd04749
COMM_Domain containing protein 1, also called Murr1. Murr1/Commd1 is a protein involved in ...
 106-188 8.22e-03

COMM_Domain containing protein 1, also called Murr1. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240097 [Multi-domain]  Cd Length: 174  Bit Score: 35.56  E-value: 8.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823942 106 NRKEIRTILNELAPRLPSYHSLEWRLDVQLASRSLRQQMKPAVTIKLHLDQSGDHSTH-CLQTDPATLLHLVQQLEQALE 184
Cdd:cd04749   90 HKKKIRESLLAQSRWENSLRGLSWRVDLKTQSRHIAQINSPVAIVELELGKTGQESEFvCLEFDEAKVNRVLKQLAEIQE 169


                 ....
gi 157823942 185 EMKT 188
Cdd:cd04749  170 SLDA 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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