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Conserved domains on  [gi|157821311|ref|NP_001102883|]
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leucine-rich repeat-containing protein 19 precursor [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR19-TM pfam15176
Leucine-rich repeat family 19 TM domain; LRR19-TM is the single-span transmembrane region of ...
 245-359 7.73e-68

Leucine-rich repeat family 19 TM domain; LRR19-TM is the single-span transmembrane region of LRRC19, a leucine-rich repeat protein family. LRRC19 functions as a transmembrane receptor inducing pro-inflammatory cytokines. This suggests its role in innate immunity. This family of proteins is found in eukaryotes.


:

Pssm-ID: 464545  Cd Length: 115  Bit Score: 208.99  E-value: 7.73e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821311  245 NLTWNSEHEPLGKSWAFLVGVVATVLLTSLLIFIAIKCPIWYNILLSYNHHRLEEHEAETYDQGLTRNPSSLSQITDTNS 324
Cdd:pfam15176   1 NLTPNSEHERSGKSWAFLVGVVVTVLMTSLLIAIAIKCPKWYNFLLSYNHHRLEEHEAETYESGDTGNPSSLSQLQATNP 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 157821311  325 EDNTVIFEQLHSFVVDDDGFIEDRYIDINEVHEEK 359
Cdd:pfam15176  81 DDTTVIFEQLHSFVVDDDGFIEDKYIDTHELKEEN 115
LRR_8 pfam13855
Leucine rich repeat;
95-154 4.80e-11

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.53  E-value: 4.80e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821311   95 NLEILNICGNSISVIQQGSFVGLNELKQLFLCQNKILQLTPDTLVPLNNLKVLDLRGNLI 154
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
38-173 2.32e-09

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.41  E-value: 2.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821311  38 IPEGISS--NVTILDLSYNQITlnaSDTRTLQMYSLLTELYLMENNITALyNNTFSNLLNLEILNICGNSISVIQQgSFV 115
Cdd:COG4886  128 LPEELANltNLKELDLSNNQLT---DLPEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLG 202

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 157821311 116 GLNELKQLFLCQNKILQLtPDTLVPLNNLKVLDLRGNLIS-LFHAPRLSHLELLTLDGN 173
Cdd:COG4886  203 NLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTdLPELGNLTNLEELDLSNN 260
LRRCT smart00082
Leucine rich repeat C-terminal domain;
173-210 1.61e-07

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 47.42  E-value: 1.61e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 157821311   173 NPWNCTCGLLDLQNWLNTSNVTLENESiTTCNYPDDLK 210
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVD-LRCASPSSLR 37
 
Name Accession Description Interval E-value
LRR19-TM pfam15176
Leucine-rich repeat family 19 TM domain; LRR19-TM is the single-span transmembrane region of ...
 245-359 7.73e-68

Leucine-rich repeat family 19 TM domain; LRR19-TM is the single-span transmembrane region of LRRC19, a leucine-rich repeat protein family. LRRC19 functions as a transmembrane receptor inducing pro-inflammatory cytokines. This suggests its role in innate immunity. This family of proteins is found in eukaryotes.


Pssm-ID: 464545  Cd Length: 115  Bit Score: 208.99  E-value: 7.73e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821311  245 NLTWNSEHEPLGKSWAFLVGVVATVLLTSLLIFIAIKCPIWYNILLSYNHHRLEEHEAETYDQGLTRNPSSLSQITDTNS 324
Cdd:pfam15176   1 NLTPNSEHERSGKSWAFLVGVVVTVLMTSLLIAIAIKCPKWYNFLLSYNHHRLEEHEAETYESGDTGNPSSLSQLQATNP 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 157821311  325 EDNTVIFEQLHSFVVDDDGFIEDRYIDINEVHEEK 359
Cdd:pfam15176  81 DDTTVIFEQLHSFVVDDDGFIEDKYIDTHELKEEN 115
LRR_8 pfam13855
Leucine rich repeat;
95-154 4.80e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.53  E-value: 4.80e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821311   95 NLEILNICGNSISVIQQGSFVGLNELKQLFLCQNKILQLTPDTLVPLNNLKVLDLRGNLI 154
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
38-173 2.32e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.41  E-value: 2.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821311  38 IPEGISS--NVTILDLSYNQITlnaSDTRTLQMYSLLTELYLMENNITALyNNTFSNLLNLEILNICGNSISVIQQgSFV 115
Cdd:COG4886  128 LPEELANltNLKELDLSNNQLT---DLPEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLG 202

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 157821311 116 GLNELKQLFLCQNKILQLtPDTLVPLNNLKVLDLRGNLIS-LFHAPRLSHLELLTLDGN 173
Cdd:COG4886  203 NLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTdLPELGNLTNLEELDLSNN 260
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 45-174 1.26e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.71  E-value: 1.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821311  45 NVTILDLSYNQITLnasdTRTLQMYSLLTELYLMENNITALYNntFSNLLNLEILNICGNSISVI--------------- 109
Cdd:cd21340   25 NLKVLYLYDNKITK----IENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVeglenltnleelhie 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821311 110 -QQ-----------GSFVGL-NELKQLFLCQNKILQLTPdtLVPLNNLKVLDLRGNLISLFHA-----PRLSHLELLTLD 171
Cdd:cd21340   99 nQRlppgekltfdpRSLAALsNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEElldllSSWPSLRELDLT 176


                 ...
gi 157821311 172 GNP 174
Cdd:cd21340  177 GNP 179
LRRCT smart00082
Leucine rich repeat C-terminal domain;
173-210 1.61e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 47.42  E-value: 1.61e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 157821311   173 NPWNCTCGLLDLQNWLNTSNVTLENESiTTCNYPDDLK 210
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVD-LRCASPSSLR 37
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 148-234 8.00e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 48.15  E-value: 8.00e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821311   148 DLRGNLISLFHA---PRLSHLELLTLDGNPWNCTCGLLDLQNWLNTSNVTLENESITTCNYPDDLKHYSIKSAP-FTTEC 223
Cdd:TIGR00864    1 DISNNKISTIEEgicANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGIPlLDSGC 80

                           90
                   ....*....|.
gi 157821311   224 HSKFISTIAED 234
Cdd:TIGR00864   81 DEEYVACLKDN 91
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 96-172 1.03e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.85  E-value: 1.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821311  96 LEILNICGNSISVIQQgsFVGLNELKQLFLCQNKILQLTP--DTLVPLNNLKVLDLRGNLISLFHAPR----LSHLELLT 169
Cdd:cd21340  122 LRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPKYRdkiiLASKSLEV 199


                 ...
gi 157821311 170 LDG 172
Cdd:cd21340  200 LDG 202
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 44-154 1.72e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.16  E-value: 1.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821311  44 SNVTILDLSYNQITlNASDT---RTLQMYSLLTELYLMENNIT---------ALYNNTfsnllNLEILNICGNSISViqQ 111
Cdd:COG5238  292 TTLTSLDLSVNRIG-DEGAIalaEGLQGNKTLHTLNLAYNGIGaqgaialakALQENT-----TLHSLDLSDNQIGD--E 363

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 157821311 112 G------SFVGLNELKQLFLCQNKILQLTPDTLVPL---NNLKVLDLRGNLI 154
Cdd:COG5238  364 GaialakYLEGNTTLRELNLGKNNIGKQGAEALIDAlqtNRLHTLILDGNLI 415
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 46-167 1.96e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.22  E-value: 1.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821311  46 VTILDLSYNQITLNAsDTRTLQMYSLlTELYLMENNITALYNNTFSNLlNLEILNICGNSISVIQQGSFVGLNELKQLFL 125
Cdd:PLN00113 430 VYFLDISNNNLQGRI-NSRKWDMPSL-QMLSLARNKFFGGLPDSFGSK-RLENLDLSRNQFSGAVPRKLGSLSELMQLKL 506

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 157821311 126 CQNKILQLTPDTLVPLNNLKVLDLRGNLI------SLFHAPRLSHLEL 167
Cdd:PLN00113 507 SENKLSGEIPDELSSCKKLVSLDLSHNQLsgqipaSFSEMPVLSQLDL 554
PLN03150 PLN03150
hypothetical protein; Provisional
 88-155 4.29e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 39.03  E-value: 4.29e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157821311  88 NTFSNLLNLEILNICGNSISVIQQGSFVGLNELKQLFLCQNKILQLTPDTLVPLNNLKVLDLRGNLIS 155
Cdd:PLN03150 436 NDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLS 503
 
Name Accession Description Interval E-value
LRR19-TM pfam15176
Leucine-rich repeat family 19 TM domain; LRR19-TM is the single-span transmembrane region of ...
 245-359 7.73e-68

Leucine-rich repeat family 19 TM domain; LRR19-TM is the single-span transmembrane region of LRRC19, a leucine-rich repeat protein family. LRRC19 functions as a transmembrane receptor inducing pro-inflammatory cytokines. This suggests its role in innate immunity. This family of proteins is found in eukaryotes.


Pssm-ID: 464545  Cd Length: 115  Bit Score: 208.99  E-value: 7.73e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821311  245 NLTWNSEHEPLGKSWAFLVGVVATVLLTSLLIFIAIKCPIWYNILLSYNHHRLEEHEAETYDQGLTRNPSSLSQITDTNS 324
Cdd:pfam15176   1 NLTPNSEHERSGKSWAFLVGVVVTVLMTSLLIAIAIKCPKWYNFLLSYNHHRLEEHEAETYESGDTGNPSSLSQLQATNP 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 157821311  325 EDNTVIFEQLHSFVVDDDGFIEDRYIDINEVHEEK 359
Cdd:pfam15176  81 DDTTVIFEQLHSFVVDDDGFIEDKYIDTHELKEEN 115
LRR_8 pfam13855
Leucine rich repeat;
95-154 4.80e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.53  E-value: 4.80e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821311   95 NLEILNICGNSISVIQQGSFVGLNELKQLFLCQNKILQLTPDTLVPLNNLKVLDLRGNLI 154
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
38-173 2.32e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.41  E-value: 2.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821311  38 IPEGISS--NVTILDLSYNQITlnaSDTRTLQMYSLLTELYLMENNITALyNNTFSNLLNLEILNICGNSISVIQQgSFV 115
Cdd:COG4886  128 LPEELANltNLKELDLSNNQLT---DLPEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLG 202

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 157821311 116 GLNELKQLFLCQNKILQLtPDTLVPLNNLKVLDLRGNLIS-LFHAPRLSHLELLTLDGN 173
Cdd:COG4886  203 NLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTdLPELGNLTNLEELDLSNN 260
LRR_8 pfam13855
Leucine rich repeat;
72-130 5.74e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.76  E-value: 5.74e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 157821311   72 LTELYLMENNITALYNNTFSNLLNLEILNICGNSISVIQQGSFVGLNELKQLFLCQNKI 130
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
54-173 1.15e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.10  E-value: 1.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821311  54 NQITLNASDTRTLQMYSLLTELYLMENNITALyNNTFSNLLNLEILNICGNSISVIQQgSFVGLNELKQLFLCQNKILQL 133
Cdd:COG4886   97 NLTELDLSGNEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL 174

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 157821311 134 tPDTLVPLNNLKVLDLRGNLISLFHAP--RLSHLELLTLDGN 173
Cdd:COG4886  175 -PEELGNLTNLKELDLSNNQITDLPEPlgNLTNLEELDLSGN 215
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 45-174 1.26e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.71  E-value: 1.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821311  45 NVTILDLSYNQITLnasdTRTLQMYSLLTELYLMENNITALYNntFSNLLNLEILNICGNSISVI--------------- 109
Cdd:cd21340   25 NLKVLYLYDNKITK----IENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVeglenltnleelhie 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821311 110 -QQ-----------GSFVGL-NELKQLFLCQNKILQLTPdtLVPLNNLKVLDLRGNLISLFHA-----PRLSHLELLTLD 171
Cdd:cd21340   99 nQRlppgekltfdpRSLAALsNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEElldllSSWPSLRELDLT 176


                 ...
gi 157821311 172 GNP 174
Cdd:cd21340  177 GNP 179
LRRCT smart00082
Leucine rich repeat C-terminal domain;
173-210 1.61e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 47.42  E-value: 1.61e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 157821311   173 NPWNCTCGLLDLQNWLNTSNVTLENESiTTCNYPDDLK 210
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVD-LRCASPSSLR 37
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 148-234 8.00e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 48.15  E-value: 8.00e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821311   148 DLRGNLISLFHA---PRLSHLELLTLDGNPWNCTCGLLDLQNWLNTSNVTLENESITTCNYPDDLKHYSIKSAP-FTTEC 223
Cdd:TIGR00864    1 DISNNKISTIEEgicANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGIPlLDSGC 80

                           90
                   ....*....|.
gi 157821311   224 HSKFISTIAED 234
Cdd:TIGR00864   81 DEEYVACLKDN 91
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 96-172 1.03e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.85  E-value: 1.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821311  96 LEILNICGNSISVIQQgsFVGLNELKQLFLCQNKILQLTP--DTLVPLNNLKVLDLRGNLISLFHAPR----LSHLELLT 169
Cdd:cd21340  122 LRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPKYRdkiiLASKSLEV 199


                 ...
gi 157821311 170 LDG 172
Cdd:cd21340  200 LDG 202
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 44-154 1.72e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.16  E-value: 1.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821311  44 SNVTILDLSYNQITlNASDT---RTLQMYSLLTELYLMENNIT---------ALYNNTfsnllNLEILNICGNSISViqQ 111
Cdd:COG5238  292 TTLTSLDLSVNRIG-DEGAIalaEGLQGNKTLHTLNLAYNGIGaqgaialakALQENT-----TLHSLDLSDNQIGD--E 363

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 157821311 112 G------SFVGLNELKQLFLCQNKILQLTPDTLVPL---NNLKVLDLRGNLI 154
Cdd:COG5238  364 GaialakYLEGNTTLRELNLGKNNIGKQGAEALIDAlqtNRLHTLILDGNLI 415
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 46-167 1.96e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.22  E-value: 1.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821311  46 VTILDLSYNQITLNAsDTRTLQMYSLlTELYLMENNITALYNNTFSNLlNLEILNICGNSISVIQQGSFVGLNELKQLFL 125
Cdd:PLN00113 430 VYFLDISNNNLQGRI-NSRKWDMPSL-QMLSLARNKFFGGLPDSFGSK-RLENLDLSRNQFSGAVPRKLGSLSELMQLKL 506

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 157821311 126 CQNKILQLTPDTLVPLNNLKVLDLRGNLI------SLFHAPRLSHLEL 167
Cdd:PLN00113 507 SENKLSGEIPDELSSCKKLVSLDLSHNQLsgqipaSFSEMPVLSQLDL 554
PLN03150 PLN03150
hypothetical protein; Provisional
 88-155 4.29e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 39.03  E-value: 4.29e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157821311  88 NTFSNLLNLEILNICGNSISVIQQGSFVGLNELKQLFLCQNKILQLTPDTLVPLNNLKVLDLRGNLIS 155
Cdd:PLN03150 436 NDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLS 503
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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