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Conserved domains on  [gi|157823627|ref|NP_001102200|]
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major facilitator superfamily domain-containing protein 12 [Rattus norvegicus]

Protein Classification

major facilitator superfamily domain-containing protein 12( domain architecture ID 13024796)

major facilitator superfamily domain-containing protein 12 (MFSD12) acts as a transporter that mediates the import of cysteine into melanosomes, thereby regulating skin pigmentation

CATH:  1.20.1250.20
Gene Symbol:  MFSD12
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26098515|26758938
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MFSD12 cd17491
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily ...
 21-465 0e+00

Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily domain-containing protein 12 (MFSD12) protein subfamily includes a group of uncharacterized proteins similar to human MFSD2. MFSD2 is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD12 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 341044  Cd Length: 438  Bit Score: 653.17  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627  21 RLSFAVGHFLNDLCAGMWFTYLLLFLHSVRGYSSRGAGLLLLLGQVADGLCTPLVGYEADRAA-CVRCGPRKAWHLAGTV 99
Cdd:cd17491    1 RIAYGVGHVLNDLCASMWFTYLLVYFHLVLGFSSALAGILLLIGQVADAISTPLVGYESDRTNgCGKYGRRKSWHLIGTI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 100 CVLLSFPFIFSPCLGCGEATPEWAALLYYGPFIVIFQFGWAATQIAHLSLIPELTTSDHEKVELTALRYAFTVVANITVY 179
Cdd:cd17491   81 CVLLSFPFIFNPCLGCSDSTSEWAKLVYYGPFIIIFQFGWAAVQISHLSLIPELTSDEHERVELTALRYAFTVIANITVY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 180 GAAWLLLHlQGSAHGGQNISvgdqlgVQDVSVFRNLALLVVGVGAVFSLLFHLGTKESRRPQHQGIEPDEHSPLVAPvPQ 259
Cdd:cd17491  161 LIAWLLLQ-QSSGDSVNPTS------AQDLPIFRNLSLIVVGIGFLFSLLFHLGTKEPRPPTDLSTTTNEGEEVTAP-EE 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 260 SLLLWKHWLQEPAFYQVGLLYMTTRLIVNLSQTYIAMYLTYSLSLPKKFIATIPLVMYLSGFFSSFLMKPINRRIGRNMT 339
Cdd:cd17491  233 PRLTWKEWLREPQFYQVALLYMCTRLIVNLSQVYIPLYLTETLQLPKESIAIVPLVMYVSGFLTSLVMKPINKKIGRKIT 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 340 YFTGLLVILAFAAWVALADNL--GVAVYGAALLLGAGCATILVTSLAMTADLIGPHTHSGAFVYGAMSFSDKVANGLAVM 417
Cdd:cd17491  313 YLLGLLFVLGFCIWVWFQSGSsrTYEIYGAAVLLGVGSATLLVTSLSMTADLIGTNTESGAFVYGAMSFTDKLSNGIAVL 392

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*...
gi 157823627 418 AVQSLHPCPSELCcgACIGFYHWVMTAVTGGVGVAAALALCSILIWPI 465
Cdd:cd17491  393 IIQSLHPCNTELD--ECISYYYRVMVVVAGGVAILAGLLLLAFLLLPK 438
 
Name Accession Description Interval E-value
MFS_MFSD12 cd17491
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily ...
 21-465 0e+00

Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily domain-containing protein 12 (MFSD12) protein subfamily includes a group of uncharacterized proteins similar to human MFSD2. MFSD2 is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD12 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341044  Cd Length: 438  Bit Score: 653.17  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627  21 RLSFAVGHFLNDLCAGMWFTYLLLFLHSVRGYSSRGAGLLLLLGQVADGLCTPLVGYEADRAA-CVRCGPRKAWHLAGTV 99
Cdd:cd17491    1 RIAYGVGHVLNDLCASMWFTYLLVYFHLVLGFSSALAGILLLIGQVADAISTPLVGYESDRTNgCGKYGRRKSWHLIGTI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 100 CVLLSFPFIFSPCLGCGEATPEWAALLYYGPFIVIFQFGWAATQIAHLSLIPELTTSDHEKVELTALRYAFTVVANITVY 179
Cdd:cd17491   81 CVLLSFPFIFNPCLGCSDSTSEWAKLVYYGPFIIIFQFGWAAVQISHLSLIPELTSDEHERVELTALRYAFTVIANITVY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 180 GAAWLLLHlQGSAHGGQNISvgdqlgVQDVSVFRNLALLVVGVGAVFSLLFHLGTKESRRPQHQGIEPDEHSPLVAPvPQ 259
Cdd:cd17491  161 LIAWLLLQ-QSSGDSVNPTS------AQDLPIFRNLSLIVVGIGFLFSLLFHLGTKEPRPPTDLSTTTNEGEEVTAP-EE 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 260 SLLLWKHWLQEPAFYQVGLLYMTTRLIVNLSQTYIAMYLTYSLSLPKKFIATIPLVMYLSGFFSSFLMKPINRRIGRNMT 339
Cdd:cd17491  233 PRLTWKEWLREPQFYQVALLYMCTRLIVNLSQVYIPLYLTETLQLPKESIAIVPLVMYVSGFLTSLVMKPINKKIGRKIT 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 340 YFTGLLVILAFAAWVALADNL--GVAVYGAALLLGAGCATILVTSLAMTADLIGPHTHSGAFVYGAMSFSDKVANGLAVM 417
Cdd:cd17491  313 YLLGLLFVLGFCIWVWFQSGSsrTYEIYGAAVLLGVGSATLLVTSLSMTADLIGTNTESGAFVYGAMSFTDKLSNGIAVL 392

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*...
gi 157823627 418 AVQSLHPCPSELCcgACIGFYHWVMTAVTGGVGVAAALALCSILIWPI 465
Cdd:cd17491  393 IIQSLHPCNTELD--ECISYYYRVMVVVAGGVAILAGLLLLAFLLLPK 438
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
12-419 4.13e-35

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 135.80  E-value: 4.13e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627  12 PPRSLSLAARLSFAVGHFLNDLCAGMWFTYLLLFLHSVRGYSSRGAGLLLLLGQVADGLCTPLVGYEADRAACvRCGPRK 91
Cdd:COG2211    3 AKKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRT-RWGRRR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627  92 AWHLAGTVCVLLSFPFIFSPclgcgEATPEWAALLYYGPFIVIFQFGWAATQIAHLSLIPELTTSDHEKVELTALRYAFT 171
Cdd:COG2211   82 PWILIGAIPLALSFVLLFTA-----PDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 172 VVANITVYGAAWLLLHLqgsahggqnisvgdqLGVQDVSVFRNLALLVVGVGAVFSLLFHLGTKESRRPqhqgiePDEHS 251
Cdd:COG2211  157 GLGGLLASVLPPPLVAA---------------FGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVP------EEEKV 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 252 PLVApvpqsllLWKHWLQEPAFYQVGLLYMTTRLIVNLSQTYIAMYLTYSLSLPKKFIATIPLVMYLSGFFSSFLMKPIN 331
Cdd:COG2211  216 SLKE-------SLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLA 288

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 332 RRIGRNMTYFTGLLVILAFAAWVALADNLGVA-VYGAALLLGAGCATILVTSLAMTADLIGPH-----THSGAFVYGAMS 405
Cdd:COG2211  289 KRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWlLLVLAALAGIGLGAILVLPWAMLADVVDYDewktgRRREGLYFGIFT 368

                        410
                 ....*....|....
gi 157823627 406 FSDKVANGLAVMAV 419
Cdd:COG2211  369 FAIKLGQALAGALA 382
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
 40-419 8.03e-15

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 76.19  E-value: 8.03e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627   40 TYLLLFLHSVRGYSSRGAGLLLLLGQVADGLCTPLVGYEADRAAcVRCGPRKAWHLAGTVCVLLSFPFIFSPCLGCGEAT 119
Cdd:pfam13347  18 TYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTR-TRWGRRRPWLLLSAIILAVSFILLFTPPELGRAPL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627  120 PEWAALLYygpfiVIFQFGWAATQIAHLSLIPELTTSDHEKVELTALRYAFtvvANITVYGAAWLLLHLQGSAHGGQNIS 199
Cdd:pfam13347  97 FIWLLATY-----ILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFF---SVGGGLLAAALAFPLVLILGGTGLER 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627  200 VGdqlgvqdvsvFRNLALLVVGVGAVFSLLFHLGTKESRRpqhqgiEPDEHSPLVAPVPQSLLLWKHWLQEPAFYQVGLL 279
Cdd:pfam13347 169 KG----------YRIFALIGAVLMLLGVIITAAGTKERVS------MRSKEDTGQKEAGSLLDMLKEVFRNRAFLILLAS 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627  280 YMTTRLIVNLSQTYIAMYLTYSLSLPKKFiATIPLVMYLSGFFSSFLMKPINRRIGRNMTYFTGLLVILAFAA--WVALA 357
Cdd:pfam13347 233 FLLAALAMGVLNGLLLYYFRYVLGNGFAA-SAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFAlaLLLGP 311

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157823627  358 DNLgVAVYGAALLLGAGCATILVTSLAMTADLI------GPHTHSGAFvYGAMSFSDKVANGLAVMAV 419
Cdd:pfam13347 312 NNT-LLFLVLYIIIGFGYGSSFFLPWSMLADVVdygelrTGKRREGTF-FAMWSFISKLATGVGLGVS 377
PRK10429 PRK10429
melibiose:sodium transporter MelB;
14-390 9.39e-07

melibiose:sodium transporter MelB;


Pssm-ID: 182453  Cd Length: 473  Bit Score: 51.25  E-value: 9.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627  14 RSLSLAARLSFAVGHFLNDLCAGMWFTYLLLFLHSVRGYSSRGAGLLLLLGQVADGLCTPLVGYEADrAACVRCGPRKAW 93
Cdd:PRK10429   1 MSISMTTKLSYGFGAFGKDFAIGIVYMYLMYYYTDVVGLSVGLVGTLFLVARIWDAINDPIMGWIVN-NTRSRWGKFKPW 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627  94 HLAGTVCVLLSFPFIFSPCLGCGEATPEWAALLYygpfiVIFQFGWAATQIAHLSLIPELTTSDHEKVELTALRYAFTVV 173
Cdd:PRK10429  80 ILIGTLANSVVLFLLFSAHLFEGTAQYVFVCVTY-----ILWGMTYTIMDIPFWSLVPTLTLDKREREQLVPYPRFFASL 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 174 ANITVYGAAWLLLhlqgSAHGGQNISVGdqlgvqdvsvFRNLALLVVGVGAVFSLLFHLGTKESRRPQHQGIEPDEHSPL 253
Cdd:PRK10429 155 AGFVTAGFTLPFV----NYVGGGDRGFG----------FQMFTLVLIAFFIVSTIITLRNVHEVYSSDNQVSAEGSHLTL 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 254 VAPVPqslLLWKHwLQEPAFYQVGLLYMTTRLIVNLSQTYIAMYLTYSLSLPKKFIATIPLVMYLSGFFSSFLMKPINRR 333
Cdd:PRK10429 221 KDIVA---LIYKN-DQLSCLLGMALAYNIASNIINGFAIYYFTYVIGDADLFPYYLSYAGAANLVTLILFPRLVKSLSRR 296

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 157823627 334 IGRNMTYFTGLL--VILAFAAWVALADNLGVAVYGAALLLGAGCATILVTslAMTADLI 390
Cdd:PRK10429 297 ILWAGASIFPVLscGVLLLMGLAAPHNALLIVIAGILLNIGTALFWVLQV--IMVADTV 353
 
Name Accession Description Interval E-value
MFS_MFSD12 cd17491
Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily ...
 21-465 0e+00

Major facilitator superfamily domain-containing protein 12; Major facilitator superfamily domain-containing protein 12 (MFSD12) protein subfamily includes a group of uncharacterized proteins similar to human MFSD2. MFSD2 is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD12 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341044  Cd Length: 438  Bit Score: 653.17  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627  21 RLSFAVGHFLNDLCAGMWFTYLLLFLHSVRGYSSRGAGLLLLLGQVADGLCTPLVGYEADRAA-CVRCGPRKAWHLAGTV 99
Cdd:cd17491    1 RIAYGVGHVLNDLCASMWFTYLLVYFHLVLGFSSALAGILLLIGQVADAISTPLVGYESDRTNgCGKYGRRKSWHLIGTI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 100 CVLLSFPFIFSPCLGCGEATPEWAALLYYGPFIVIFQFGWAATQIAHLSLIPELTTSDHEKVELTALRYAFTVVANITVY 179
Cdd:cd17491   81 CVLLSFPFIFNPCLGCSDSTSEWAKLVYYGPFIIIFQFGWAAVQISHLSLIPELTSDEHERVELTALRYAFTVIANITVY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 180 GAAWLLLHlQGSAHGGQNISvgdqlgVQDVSVFRNLALLVVGVGAVFSLLFHLGTKESRRPQHQGIEPDEHSPLVAPvPQ 259
Cdd:cd17491  161 LIAWLLLQ-QSSGDSVNPTS------AQDLPIFRNLSLIVVGIGFLFSLLFHLGTKEPRPPTDLSTTTNEGEEVTAP-EE 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 260 SLLLWKHWLQEPAFYQVGLLYMTTRLIVNLSQTYIAMYLTYSLSLPKKFIATIPLVMYLSGFFSSFLMKPINRRIGRNMT 339
Cdd:cd17491  233 PRLTWKEWLREPQFYQVALLYMCTRLIVNLSQVYIPLYLTETLQLPKESIAIVPLVMYVSGFLTSLVMKPINKKIGRKIT 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 340 YFTGLLVILAFAAWVALADNL--GVAVYGAALLLGAGCATILVTSLAMTADLIGPHTHSGAFVYGAMSFSDKVANGLAVM 417
Cdd:cd17491  313 YLLGLLFVLGFCIWVWFQSGSsrTYEIYGAAVLLGVGSATLLVTSLSMTADLIGTNTESGAFVYGAMSFTDKLSNGIAVL 392

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*...
gi 157823627 418 AVQSLHPCPSELCcgACIGFYHWVMTAVTGGVGVAAALALCSILIWPI 465
Cdd:cd17491  393 IIQSLHPCNTELD--ECISYYYRVMVVVAGGVAILAGLLLLAFLLLPK 438
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 21-459 2.39e-65

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 216.70  E-value: 2.39e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627  21 RLSFAVGHFLNDLCAGMWFTYLLLFLHSVRGYSSRGAGLLLLLGQVADGLCTPLVGYEADRAAcVRCGPRKAWHLAGTVC 100
Cdd:cd17332    1 KIGYGLGDFGNNLIFQIVSTYLLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTR-SRWGRFRPWLLWGAIP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 101 VLLSFPFIFSPCLGCGeatpeWAALLYYGPFIVIFQFGWAATQIAHLSLIPELTTSDHEKVELTALRYAFTVVANITVYG 180
Cdd:cd17332   80 LALLFVLLFTTPDGSG-----TGKLIYALITYILLDLLYTLVNIPYTALIPELTDDPEERTSLTSWRMFFATIGGLLVTV 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 181 AAWLLLHLQGSAHGGQnisvgdqlgvqdvsVFRNLALLVVGVGAVFSLLFHLGTKESRRPQhqgIEPDEHSPLvapvpqs 260
Cdd:cd17332  155 LPPPLVAYFGGGNASR--------------GYFLTALIIGIIGIILLLICFFGTRERVVPP---EEEKSKLPL------- 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 261 LLLWKHWLQEPAFYQVGLLYMTTRLIVNLSQTYIAMYLTYslSLPKKFIATIPLVMYLSGFFSSFLMKPIN-RRIGRNMT 339
Cdd:cd17332  211 LKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKY--VLGGRAELVLLLLLILSGALLALLPWPPLkKRFGKKKA 288

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 340 YFTGLLV-ILAFAAWVALADNLGVAVYGAALLLGAGCATILVTSLAMTADLIGPHT-HSG----AFVYGAMSFSDKVANG 413
Cdd:cd17332  289 FFIGLLLaILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLLPWAMLADVIDYGElKTGkrreGIFYSVMTFFRKLGLA 368

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|
gi 157823627 414 LAVMAVQSLHPC----PSELCCGACIGFYHWVMTAVTGGVGVAAALALCS 459
Cdd:cd17332  369 LAGALVGLILSLagyvANAAAQSASALNGIRLLIAVLPAVLLLLALILMS 418
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
12-419 4.13e-35

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 135.80  E-value: 4.13e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627  12 PPRSLSLAARLSFAVGHFLNDLCAGMWFTYLLLFLHSVRGYSSRGAGLLLLLGQVADGLCTPLVGYEADRAACvRCGPRK 91
Cdd:COG2211    3 AKKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRT-RWGRRR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627  92 AWHLAGTVCVLLSFPFIFSPclgcgEATPEWAALLYYGPFIVIFQFGWAATQIAHLSLIPELTTSDHEKVELTALRYAFT 171
Cdd:COG2211   82 PWILIGAIPLALSFVLLFTA-----PDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 172 VVANITVYGAAWLLLHLqgsahggqnisvgdqLGVQDVSVFRNLALLVVGVGAVFSLLFHLGTKESRRPqhqgiePDEHS 251
Cdd:COG2211  157 GLGGLLASVLPPPLVAA---------------FGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVP------EEEKV 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 252 PLVApvpqsllLWKHWLQEPAFYQVGLLYMTTRLIVNLSQTYIAMYLTYSLSLPKKFIATIPLVMYLSGFFSSFLMKPIN 331
Cdd:COG2211  216 SLKE-------SLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLA 288

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 332 RRIGRNMTYFTGLLVILAFAAWVALADNLGVA-VYGAALLLGAGCATILVTSLAMTADLIGPH-----THSGAFVYGAMS 405
Cdd:COG2211  289 KRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWlLLVLAALAGIGLGAILVLPWAMLADVVDYDewktgRRREGLYFGIFT 368

                        410
                 ....*....|....
gi 157823627 406 FSDKVANGLAVMAV 419
Cdd:COG2211  369 FAIKLGQALAGALA 382
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
 40-419 8.03e-15

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 76.19  E-value: 8.03e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627   40 TYLLLFLHSVRGYSSRGAGLLLLLGQVADGLCTPLVGYEADRAAcVRCGPRKAWHLAGTVCVLLSFPFIFSPCLGCGEAT 119
Cdd:pfam13347  18 TYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTR-TRWGRRRPWLLLSAIILAVSFILLFTPPELGRAPL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627  120 PEWAALLYygpfiVIFQFGWAATQIAHLSLIPELTTSDHEKVELTALRYAFtvvANITVYGAAWLLLHLQGSAHGGQNIS 199
Cdd:pfam13347  97 FIWLLATY-----ILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFF---SVGGGLLAAALAFPLVLILGGTGLER 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627  200 VGdqlgvqdvsvFRNLALLVVGVGAVFSLLFHLGTKESRRpqhqgiEPDEHSPLVAPVPQSLLLWKHWLQEPAFYQVGLL 279
Cdd:pfam13347 169 KG----------YRIFALIGAVLMLLGVIITAAGTKERVS------MRSKEDTGQKEAGSLLDMLKEVFRNRAFLILLAS 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627  280 YMTTRLIVNLSQTYIAMYLTYSLSLPKKFiATIPLVMYLSGFFSSFLMKPINRRIGRNMTYFTGLLVILAFAA--WVALA 357
Cdd:pfam13347 233 FLLAALAMGVLNGLLLYYFRYVLGNGFAA-SAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFAlaLLLGP 311

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157823627  358 DNLgVAVYGAALLLGAGCATILVTSLAMTADLI------GPHTHSGAFvYGAMSFSDKVANGLAVMAV 419
Cdd:pfam13347 312 NNT-LLFLVLYIIIGFGYGSSFFLPWSMLADVVdygelrTGKRREGTF-FAMWSFISKLATGVGLGVS 377
PRK10429 PRK10429
melibiose:sodium transporter MelB;
14-390 9.39e-07

melibiose:sodium transporter MelB;


Pssm-ID: 182453  Cd Length: 473  Bit Score: 51.25  E-value: 9.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627  14 RSLSLAARLSFAVGHFLNDLCAGMWFTYLLLFLHSVRGYSSRGAGLLLLLGQVADGLCTPLVGYEADrAACVRCGPRKAW 93
Cdd:PRK10429   1 MSISMTTKLSYGFGAFGKDFAIGIVYMYLMYYYTDVVGLSVGLVGTLFLVARIWDAINDPIMGWIVN-NTRSRWGKFKPW 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627  94 HLAGTVCVLLSFPFIFSPCLGCGEATPEWAALLYygpfiVIFQFGWAATQIAHLSLIPELTTSDHEKVELTALRYAFTVV 173
Cdd:PRK10429  80 ILIGTLANSVVLFLLFSAHLFEGTAQYVFVCVTY-----ILWGMTYTIMDIPFWSLVPTLTLDKREREQLVPYPRFFASL 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 174 ANITVYGAAWLLLhlqgSAHGGQNISVGdqlgvqdvsvFRNLALLVVGVGAVFSLLFHLGTKESRRPQHQGIEPDEHSPL 253
Cdd:PRK10429 155 AGFVTAGFTLPFV----NYVGGGDRGFG----------FQMFTLVLIAFFIVSTIITLRNVHEVYSSDNQVSAEGSHLTL 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 254 VAPVPqslLLWKHwLQEPAFYQVGLLYMTTRLIVNLSQTYIAMYLTYSLSLPKKFIATIPLVMYLSGFFSSFLMKPINRR 333
Cdd:PRK10429 221 KDIVA---LIYKN-DQLSCLLGMALAYNIASNIINGFAIYYFTYVIGDADLFPYYLSYAGAANLVTLILFPRLVKSLSRR 296

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 157823627 334 IGRNMTYFTGLL--VILAFAAWVALADNLGVAVYGAALLLGAGCATILVTslAMTADLI 390
Cdd:PRK10429 297 ILWAGASIFPVLscGVLLLMGLAAPHNALLIVIAGILLNIGTALFWVLQV--IMVADTV 353
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 218-392 1.38e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 47.19  E-value: 1.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 218 LVVGVGAVFSLLFHLGTKESRRPQHQGIEPDEHSplvapvpqSLLLWKHWLQEPAFYQVGLLYMTTRLIVNLSQTYIAMY 297
Cdd:cd17325  154 LVCAALALLALVLALLLLPEPRPPPNKRAVSAAR--------LRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLY 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 298 LTYSLSLPKKFIATIPLVMYLSGFFSSFLMKPINRRIGRNMTYFTGLLVILAFAAWVALADNLgVAVYGAALLLGAGCAT 377
Cdd:cd17325  226 AAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSF-WLLLLLLALLGLGLGL 304

                        170
                 ....*....|....*
gi 157823627 378 ILVTSLAMTADLIGP 392
Cdd:cd17325  305 VFPATLALLADIVPP 319
MFS_MFSD2 cd17392
Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator ...
 21-423 2.13e-05

Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator superfamily domain-containing protein 2 (MFSD2) subfamily is composed of two vertebrate members, MFSD2A amd MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD2 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340950  Cd Length: 446  Bit Score: 46.69  E-value: 2.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627  21 RLSFAVGHFLNDLCAGMWFTYLLLFLHSVRGYSSRGAGLLLLLGQVADGLCTPLVGYEADRAACVRCGPRKAWHLAGTVC 100
Cdd:cd17392    1 KLCYAIGGAPYQMTSSATGFFLQIFLLDVAQMGAFSVSLILFVGRVWDAVTDPLVGYFISRSQRTGIGRLMPWIVFSTPL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 101 VLLSFPFIFspclgcgeATPEWAAL--LYYGPFIVIFQFGWAATQIAHLSLIPELTTSDHEKVELTAlrYAFTVVANITV 178
Cdd:cd17392   81 IILAYFFLW--------FLPPFTSLsgLWYLTFYCLFETFMTCFHVPYSALTMFLGGCQRERDSATA--YRMTVEVFGTL 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 179 YGAAwlllhLQGSAHGG------QNISVGDQLGVQDVSVFRNL-------ALLVVGVGAVFSLLFHLGTKESRRPqhqgi 245
Cdd:cd17392  151 MGAT-----IQGQIVGVahrprrQDCTATPGTSDHPVTVLPNTrrayliaALVVVVLYFVCCSILFLGVKEQPDP----- 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 246 epdeHSPLVAPVPQSLLLWKHWLQEPAFYQVGLLYMTTRLIVNLSQTYIAMYLTYSLSLPKKFiATIPLVMYLSGFFSSF 325
Cdd:cd17392  221 ----LSPASGPGLSYLAGLKLVTGHPPYLKLVIGFLFSSLAFQMEQGNFVLFCTHAAGLGDHF-QHLVLAILVSATLSIP 295

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 326 LMKPINRRIGRNMTYFTGLLVILAFAAWVALADNLGVAVYGAALLLGAGCATILVTSLAMTADLI------GPHTHS-GA 398
Cdd:cd17392  296 LWQWVLQRRGKKTTSFIGISAMVPFLILLALVPSNLPVAYVVAVVSGVSLAALFLLPWSMLPDVVddfqlkNPHCPGlEP 375

                        410       420
                 ....*....|....*....|....*.
gi 157823627 399 FVYGAMSFSDKVANGLAV-MAVQSLH 423
Cdd:cd17392  376 IFYSCYVFFTKLGGGLSLgISTLSLH 401
MFS_MFSD2B cd17452
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily ...
 21-390 3.59e-05

Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily domain-containing protein 2B (MFSD2B) is closely related to MFSD2A, and their conserved genomic structure suggests that they are derived from the duplication of an ancestral gene. Variations of chromosome 2 gene expressions among patients with lung cancer or non-cancer identified MFSD2B as a potential risk or protect factor in the prognosis of lung adenocarcinoma. MFSD2B belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341010  Cd Length: 416  Bit Score: 45.96  E-value: 3.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627  21 RLSFAVGHFLNDLCAGMWFTYLLLFLHSVRGYSSRGAGLLLLLGQVADGLCTPLVGYEADRAACVRCGPRKAWHLAGTVC 100
Cdd:cd17452    1 KLCYAIGGAPNQVAGSATAFFLQIYLLDIAQITPFQASLVLFVGKAWGAATDPVVGFFISKSKWTKIGRLMPWMLGCTPF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 101 VLLSFPFI-FSPCLGCGEatpewaaLLYYGPFIVIFQFGWAATQIAHLSLIPELTTSDHEKVELTALRYAFTVVANITvy 179
Cdd:cd17452   81 IVVSYFFLwFVPPFTTGR-------FLWYLTFYCLFQALATCFHVPYSALTMFLSTDQRERDSATAYRMTVEVLGTLV-- 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 180 gaawlllhlqGSAHGGQNISvgdqlgvqdvSVFRNLALLVVGVGAVFSLLFHLGTKEsrrpqhqgiEPDEHSPLVAPVPQ 259
Cdd:cd17452  152 ----------GAAVQGQIVA----------SAYMIAAGVIGGLYLLCISVLFLGVKE---------RDDPYAPKSGKAIP 202

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 260 SLLLWKHWLQEPAFYQVGLLYMTTRLIVNLSQTYIAMYLTYSLSLPKKFiATIPLVMYLSGFFSSFLMKPINRRIGRNMT 339
Cdd:cd17452  203 FFKGLSLTMRHGPYLKLTASFLFISAAVQLEQSNFVLFCTHAVDLHDHF-QNLVLTILVSAVVSIPFWQWFLQRFGKKAA 281

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 157823627 340 YFtGLLVILAFAAWVALADNLGVAvYGAALLLGAGCATILVTSLAMTADLI 390
Cdd:cd17452  282 AC-GISWMIPFAIMLVTIPNLIVA-YVVAFVSGLSIAASLLLPWSMLPDVV 330
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 276-407 2.06e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 43.57  E-value: 2.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 276 VGLLYMTTRLIVNLSQTYIAMYLTySLSLPKKFIATIPLVMYLSGFFSSFLMKPINRRIGRNMTYFTGLLVILAFAAWVA 355
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQ-SFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 157823627 356 LADNLGVaVYGAALLLGAGCATILVTSLAMTADLIGPHTHSGAFVYGAMSFS 407
Cdd:cd06174   80 FAPSFWL-LLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGS 130
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
212-393 2.06e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 43.42  E-value: 2.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 212 FRNLALLVVGVGAVFSLLFHLGTKESRRPQHQGIEPDehsplvapvpqslllWKHWLQEPAFYQVGLLYMTTRLIVNLSQ 291
Cdd:COG2814  163 WRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGS---------------LRELLRRPRLLLLLLLAFLLGFGFFALF 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 292 TYIAMYLTYSLSLPKKFIATIPLVMYLSGFFSSFLMKPINRRIGRNMTYFTGLLVILAFAAWVALADNLgVAVYGAALLL 371
Cdd:COG2814  228 TYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSL-WLLLLALFLL 306

                        170       180
                 ....*....|....*....|..
gi 157823627 372 GAGCATILVTSLAMTADLIGPH 393
Cdd:COG2814  307 GFGFGLLFPLLQALVAELAPPE 328
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 310-405 6.86e-04

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 41.79  E-value: 6.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 310 ATIPLVMYLSGF-FSSFLMKPINRRIGRNMTYFTGLLVILAFAAWVALADNLGvAVYGAALLLGAGCATILVTSLAMTAD 388
Cdd:cd17323   36 ANLGVSLFVLGFgLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIA-MLIILRFLQGFFGSSPLAIGAGTIAD 114

                         90
                 ....*....|....*..
gi 157823627 389 LIGPHTHSGAFVYGAMS 405
Cdd:cd17323  115 LFTPEERGKAMGVYSLG 131
MFS_1 pfam07690
Major Facilitator Superfamily;
276-407 7.74e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 41.63  E-value: 7.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627  276 VGLLYMTTRLIVNLSQTYIAMYLTYSLSLPKKFIATIPLVMYLSGFFSSFLMKPINRRIGRNMTYFTGLLVILAFAAWVA 355
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 157823627  356 LADNLgVAVYGAALLLGAGCATILVTSLAMTADLIGPHTHSGAFVYGAMSFS 407
Cdd:pfam07690  81 FASSL-WLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFG 131
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 24-415 8.82e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 41.64  E-value: 8.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627  24 FAVGHFLNDLCAGMWFTYLLLFLHSVRGYSSRgAGLLLLLGQVADGLCTPLVGYEADraacvRCGPRKAWHLAGTVCVLL 103
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQ-LGLLFALFSLGYALLQPLAGLLAD-----RFGRRPVLLLGLLLFALG 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 104 SFPFIFSPCLgcgeatpeWAALLYYgpfiVIFQFGWAATQIAHLSLIPELtTSDHEKVELTALRYAFTVVANITVYGAA- 182
Cdd:cd06174   75 ALLFAFAPSF--------WLLLLGR----FLLGLGSGLIDPAVLALIADL-FPERERGRALGLLQAFGSVGGILGPLLGg 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 183 WLLLHLQGSAHggqnisvgdqlgvqdvsvfrnLALLVVGVGAVFSLLFHLGTKESRRPQHQGIEPDEHSplvapvPQSLL 262
Cdd:cd06174  142 ILASSLGFGWR---------------------AVFLIAAALALLAAILLLLVVPDPPESARAKNEEASS------KSVLK 194

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 263 LWKHWLQEPAFYQVGLLYMTTRLIVNLSQTYIAMYLTYSLSLPKKFIATIPLVMYLSGFFSSFLMKPINRR-IGRNMTYF 341
Cdd:cd06174  195 LLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLL 274

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157823627 342 TGLLVILAFAAWVALADNLGVAVyGAALLLGAGCATILVTSLAMTADLIGPhtHSGAFVYGAMSFSDKVANGLA 415
Cdd:cd06174  275 IGLLLMALGLALLLLAPSLLLLL-LLLLLLGFGLGGLLPLSFALIAELFPP--EIRGTAFGLLNTFGFLGGAIG 345
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
292-398 1.37e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 40.99  E-value: 1.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 292 TYIAMYLTYSLSLPKKFIATIPLVMYLSGFFSSFLMKPINRRIGRNMTYFTGLLVILAFAAWVALADNLGVAVYGAAlLL 371
Cdd:COG0738  231 DWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLA-LV 309

                         90       100
                 ....*....|....*....|....*..
gi 157823627 372 GAGCATILVTSLAMTADLIGPHTHSGA 398
Cdd:COG0738  310 GLGLSLMFPTIFSLALDGLGKRTAAAV 336
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 70-396 2.81e-03

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 39.92  E-value: 2.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627  70 LCTPLVGYEADRAAcVRCGPRKAWHLAGTVCVLLSF---PFIFSPCLGCGEATPEWAALLYYGpFIVIFQFGWAATQIAH 146
Cdd:cd17313   49 FVQPLVGSLSDRCN-SRIGRRRPFILVGAPLAALGLiliPNAADIGLALGDGPRTWALVLFVL-GIVLLDFAMNVCQGPV 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 147 LSLIPELTTSDHEkveltalRYAFTVVANITVYGAAwlLLHLQGSAHGGQNISvGDQLGVQDVSVFrnlallvvGVGAVF 226
Cdd:cd17313  127 RALLPDLVPPEQR-------SKANGIINFMGGLGGV--LGYLLGAILWDHNWF-GFALGGNLKVPF--------YIGAII 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 227 SLLFHLGTKESRRPQHQGIEPDEHSPLVAPVPQSLLLWKHWLQEP----------AFYQVG----LLYMTTRLIVNLSQT 292
Cdd:cd17313  189 LLVCVLVTLFFVKEPPLSPEAGEHSENPSLGEVLKSLLKLLKIMPrsllrlllviFFWWIAffpfELFFTDYMGEEVYHG 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 293 YIAMYLTYSLSlpkKFIATIPLVMY-LSGFFSSFLMKPINRRIGRNMTYFTGLLVILAFAAWVALADNLGVAVYGAAlLL 371
Cdd:cd17313  269 TSAASSHYGAG---VRMGAWGLLIFsLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFA-LG 344

                        330       340
                 ....*....|....*....|....*
gi 157823627 372 GAGCATILVTSLAMTADLIGPHTHS 396
Cdd:cd17313  345 GIGWATININPYPLVSDYHSESGRG 369
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 306-407 3.50e-03

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 39.49  E-value: 3.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 306 KKFIATIPLVMYLSGFFS-SFLMKPINRRIGRNMTYFTGLLVILAFAAWVALADNlgVAVY-GAALLLGAGCATILVTSL 383
Cdd:cd17317   23 RDWLVALVQTIFFLGVLIgSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPS--YELFlVLRFLVGVTSAGIFTVGF 100

                         90       100
                 ....*....|....*....|....
gi 157823627 384 AMTADLIGPHTHSGAFVYGAMSFS 407
Cdd:cd17317  101 VLGMEIVGPKYRSFVGILFGLFWA 124
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
276-407 7.26e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 38.42  E-value: 7.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823627 276 VGLLYMTTRLIVNLSQTYIAMYLTYSLSLpkkfIATIPLVMYLSGFFSSFLMKPINRRIGRNMTYFTGLLVILAFAAWVA 355
Cdd:COG2814   18 GAFLSGLGIGIVLPALPLIAADLGASPAQ----AGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA 93

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 157823627 356 LADNLGVaVYGAALLLGAGCATILVTSLAMTADLIGPHTHSGAFVYGAMSFS 407
Cdd:COG2814   94 LAPSLWL-LLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLG 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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