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Conserved domains on  [gi|157819989|ref|NP_001102065|]
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N-alpha-acetyltransferase 20 isoform a [Rattus norvegicus]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 11418877)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 71-167 1.96e-16

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


:

Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 70.84  E-value: 1.96e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819989  71 AEGSVAREEWHGHVTALSVAPEFRRLGLAAKLMELLEEISERKGGFFVDLFVRVSNQVAVNMYKQLGYSVYRTVIEYYsa 150
Cdd:COG0456    3 ALLGLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLGFEEVGERPNYY-- 80

                         90
                 ....*....|....*..
gi 157819989 151 sngepDEDAYDMRKALS 167
Cdd:COG0456   81 -----GDDALVMEKELA 92
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 71-167 1.96e-16

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 70.84  E-value: 1.96e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819989  71 AEGSVAREEWHGHVTALSVAPEFRRLGLAAKLMELLEEISERKGGFFVDLFVRVSNQVAVNMYKQLGYSVYRTVIEYYsa 150
Cdd:COG0456    3 ALLGLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLGFEEVGERPNYY-- 80

                         90
                 ....*....|....*..
gi 157819989 151 sngepDEDAYDMRKALS 167
Cdd:COG0456   81 -----GDDALVMEKELA 92
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 12-138 1.02e-14

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 67.16  E-value: 1.02e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819989   12 LFRFNNINLDPLTETYGIPFY---LQYLAHWPEYFIVAEApGGELMGYskysttstflVMGKAEGsvaREEWHGHVTALS 88
Cdd:pfam00583   1 LEALYELLSEEFPEPWPDEPLdllEDWDEDASEGFFVAEE-DGELVGF----------ASLSIID---DEPPVGEIEGLA 66

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 157819989   89 VAPEFRRLGLAAKLMELLEEISERKGGFFVDLFVRVSNQVAVNMYKQLGY 138
Cdd:pfam00583  67 VAPEYRGKGIGTALLQALLEWARERGCERIFLEVAADNLAAIALYEKLGF 116
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 22-162 8.95e-13

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 62.35  E-value: 8.95e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819989   22 PLTETYGIPFYLQYLAHWpeyfIVAEApGGELMGYskysttstflvmgkAEGSVAREEwhGHVTALSVAPEFRRLGLAAK 101
Cdd:TIGR01575  16 PWTEAQFAEELANYHLCY----LLARI-GGKVVGY--------------AGVQIVLDE--AHILNIAVKPEYQGQGIGRA 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157819989  102 LMELLEEISERKGGFFVDLFVRVSNQVAVNMYKQLGYSVYRTVIEYYSasngEPDEDAYDM 162
Cdd:TIGR01575  75 LLRELIDEAKGRGVNEIFLEVRVSNIAAQALYKKLGFNEIAIRRNYYP----DPGEDAIVM 131
PRK03624 PRK03624
putative acetyltransferase; Provisional
 36-140 7.13e-10

putative acetyltransferase; Provisional


Pssm-ID: 235142 [Multi-domain]  Cd Length: 140  Bit Score: 54.55  E-value: 7.13e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819989  36 LAHWPEYFIVAEApGGELMGyskysttstfLVMGKAEGsvareewH-GHVTALSVAPEFRRLGLAAKLMELLEEISERKG 114
Cdd:PRK03624  40 LNHDPSLFLVAEV-GGEVVG----------TVMGGYDG-------HrGWAYYLAVHPDFRGRGIGRALVARLEKKLIARG 101

                         90       100
                 ....*....|....*....|....*.
gi 157819989 115 GFFVDLFVRVSNQVAVNMYKQLGYSV 140
Cdd:PRK03624 102 CPKINLQVREDNDAVLGFYEALGYEE 127
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 43-120 5.11e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 39.57  E-value: 5.11e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157819989  43 FIVAEApGGELMGYskysttstflVMGKAEGSVAReewHGHVTALSVAPEFRRLGLAAKLMELLEEISERKGGFFVDL 120
Cdd:cd04301    1 FLVAED-DGEIVGF----------ASLSPDGSGGD---TAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRL 64
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 71-167 1.96e-16

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 70.84  E-value: 1.96e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819989  71 AEGSVAREEWHGHVTALSVAPEFRRLGLAAKLMELLEEISERKGGFFVDLFVRVSNQVAVNMYKQLGYSVYRTVIEYYsa 150
Cdd:COG0456    3 ALLGLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLGFEEVGERPNYY-- 80

                         90
                 ....*....|....*..
gi 157819989 151 sngepDEDAYDMRKALS 167
Cdd:COG0456   81 -----GDDALVMEKELA 92
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 12-138 1.02e-14

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 67.16  E-value: 1.02e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819989   12 LFRFNNINLDPLTETYGIPFY---LQYLAHWPEYFIVAEApGGELMGYskysttstflVMGKAEGsvaREEWHGHVTALS 88
Cdd:pfam00583   1 LEALYELLSEEFPEPWPDEPLdllEDWDEDASEGFFVAEE-DGELVGF----------ASLSIID---DEPPVGEIEGLA 66

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 157819989   89 VAPEFRRLGLAAKLMELLEEISERKGGFFVDLFVRVSNQVAVNMYKQLGY 138
Cdd:pfam00583  67 VAPEYRGKGIGTALLQALLEWARERGCERIFLEVAADNLAAIALYEKLGF 116
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 22-162 8.95e-13

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 62.35  E-value: 8.95e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819989   22 PLTETYGIPFYLQYLAHWpeyfIVAEApGGELMGYskysttstflvmgkAEGSVAREEwhGHVTALSVAPEFRRLGLAAK 101
Cdd:TIGR01575  16 PWTEAQFAEELANYHLCY----LLARI-GGKVVGY--------------AGVQIVLDE--AHILNIAVKPEYQGQGIGRA 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157819989  102 LMELLEEISERKGGFFVDLFVRVSNQVAVNMYKQLGYSVYRTVIEYYSasngEPDEDAYDM 162
Cdd:TIGR01575  75 LLRELIDEAKGRGVNEIFLEVRVSNIAAQALYKKLGFNEIAIRRNYYP----DPGEDAIVM 131
PRK03624 PRK03624
putative acetyltransferase; Provisional
 36-140 7.13e-10

putative acetyltransferase; Provisional


Pssm-ID: 235142 [Multi-domain]  Cd Length: 140  Bit Score: 54.55  E-value: 7.13e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819989  36 LAHWPEYFIVAEApGGELMGyskysttstfLVMGKAEGsvareewH-GHVTALSVAPEFRRLGLAAKLMELLEEISERKG 114
Cdd:PRK03624  40 LNHDPSLFLVAEV-GGEVVG----------TVMGGYDG-------HrGWAYYLAVHPDFRGRGIGRALVARLEKKLIARG 101

                         90       100
                 ....*....|....*....|....*.
gi 157819989 115 GFFVDLFVRVSNQVAVNMYKQLGYSV 140
Cdd:PRK03624 102 CPKINLQVREDNDAVLGFYEALGYEE 127
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
73-147 1.18e-09

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 52.60  E-value: 1.18e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157819989  73 GSVAREEWHGHVTALSVAPEFRRLGLAAKLMELLEEISERKGGFFVDLFVRVSNQVAVNMYKQLGYSVYRTVIEY 147
Cdd:COG3393    7 GVRAESPGVAEISGVYTHPEYRGRGLASALVAALAREALARGARTPFLYVDADNPAARRLYERLGFRPVGEYATV 81
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
1-166 8.13e-09

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 52.30  E-value: 8.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819989   1 MTTLRAFTCDDL---FRFNNINLDPLTETYGI-PFYLQYLAHW------PEY-FIVAEApGGELMGYSKYSTTSTFLVMG 69
Cdd:COG1247    1 EMTIRPATPEDApaiAAIYNEAIAEGTATFETePPSEEEREAWfaailaPGRpVLVAEE-DGEVVGFASLGPFRPRPAYR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819989  70 K-AEGSVAreewhghvtalsVAPEFRRLGLAAKLMELLEEISERKGGFFVDLFVRVSNQVAVNMYKQLGYSVYRTVIEYY 148
Cdd:COG1247   80 GtAEESIY------------VDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLGFEEVGTLPEVG 147

                        170
                 ....*....|....*...
gi 157819989 149 SASNGEPDEdaYDMRKAL 166
Cdd:COG1247  148 FKFGRWLDL--VLMQKRL 163
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
89-167 9.61e-08

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 48.64  E-value: 9.61e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819989  89 VAPEFRRLGLAAKLMELLEEISERKGGFFVDLFVRVSnqvAVNMYKQLGYSVYrtvieyysasnGEPDEDA----YDMRK 164
Cdd:COG2153   66 VLPEYRGQGLGRALMEAAIEEARERGARRIVLSAQAH---AVGFYEKLGFVPV-----------GEEFLEAgiphIDMRK 131


                 ...
gi 157819989 165 ALS 167
Cdd:COG2153  132 PLS 134
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 41-140 3.70e-07

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 45.91  E-value: 3.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819989   41 EYFIVAEAPGGelmgyskysttstflVMGKAEGSVAREEWHGHVTALSVAPEFRRLGLAAKLMELLEEISERKGgffVDL 120
Cdd:pfam13508   3 GRFFVAEDDGK---------------IVGFAALLPLDDEGALAELRLAVHPEYRGQGIGRALLEAAEAAAKEGG---IKL 64

                          90       100
                  ....*....|....*....|
gi 157819989  121 FVRVSNQVAVNMYKQLGYSV 140
Cdd:pfam13508  65 LELETTNRAAAFYEKLGFEE 84
rimI PRK09491
ribosomal-protein-alanine N-acetyltransferase; Provisional
 87-162 1.86e-06

ribosomal-protein-alanine N-acetyltransferase; Provisional


Pssm-ID: 181904 [Multi-domain]  Cd Length: 146  Bit Score: 45.31  E-value: 1.86e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157819989  87 LSVAPEFRRLGLAAKLMELLEEISERKGGFFVDLFVRVSNQVAVNMYKQLGY---SVYRtviEYYSASNGEpdEDAYDM 162
Cdd:PRK09491  69 IAVDPDYQRQGLGRALLEHLIDELEKRGVATLWLEVRASNAAAIALYESLGFnevTIRR---NYYPTADGR--EDAIIM 142
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 41-147 1.90e-06

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 45.43  E-value: 1.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819989  41 EYFIVAEApGGELMGYSKYSTTstflvmgkaegsvarEEWHGHVTALSVAPEFRRLGLAAKLMELLEEISERKGGFFVDL 120
Cdd:COG0454   34 AEFIAVDD-KGEPIGFAGLRRL---------------DDKVLELKRLYVLPEYRGKGIGKALLEALLEWARERGCTALEL 97

                         90       100
                 ....*....|....*....|....*..
gi 157819989 121 FVRVSNQVAVNMYKQLGYSVYRTVIEY 147
Cdd:COG0454   98 DTLDGNPAAIRFYERLGFKEIERYVAY 124
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 81-138 3.23e-06

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 44.57  E-value: 3.23e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 157819989   81 HGHVTALSVAPEFRRLGLAAKLMELLEEISERKGGFFVDLFVRVSNQvAVNMYKQLGY 138
Cdd:pfam13673  51 RGHISLLFVDPDYQGQGIGKALLEAVEDYAEKDGIKLSELTVNASPY-AVPFYEKLGF 107
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
40-166 4.18e-06

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 44.31  E-value: 4.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819989  40 PEYFIVAEApGGELMGYSKYSttstflvmgkaEGSVAREEWHGHVTALSVAPEFRRLGLAAKLMELLEEISERKGgffVD 119
Cdd:COG3153   38 AGLSLVAED-DGEIVGHVALS-----------PVDIDGEGPALLLGPLAVDPEYRGQGIGRALMRAALEAARERG---AR 102

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 157819989 120 LFVRVSNQVAVNMYKQLGYSVYRTVieyysasNGEPDEDAYDMRKAL 166
Cdd:COG3153  103 AVVLLGDPSLLPFYERFGFRPAGEL-------GLTLGPDEVFLAKEL 142
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 64-140 6.06e-06

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 43.83  E-value: 6.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819989  64 TFLVM---GKAEGSVA---REEWHGHVTALSVAPEFRRLGLAAKLMELLEEISERKGgfFVDLFVrVSNQVAVNMYKQLG 137
Cdd:COG1246   29 EFWVAeedGEIVGCAAlhpLDEDLAELRSLAVHPDYRGRGIGRRLLEALLAEARELG--LKRLFL-LTTSAAIHFYEKLG 105


                 ...
gi 157819989 138 YSV 140
Cdd:COG1246  106 FEE 108
FR47 pfam08445
FR47-like protein; The members of this family are similar to the C-terminal region of the D. ...
 82-143 3.08e-05

FR47-like protein; The members of this family are similar to the C-terminal region of the D. melanogaster hypothetical protein FR47. This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.


Pssm-ID: 117022 [Multi-domain]  Cd Length: 86  Bit Score: 40.78  E-value: 3.08e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157819989   82 GHVTALSVAPEFRRLGLAAKLM-ELLEEISERkgGFFVDLFVRVSNQVAVNMYKQLGYSVYRT 143
Cdd:pfam08445  22 GELGALQTLPEHRRRGLGSRLVaALARGIAER--GITPFAVVVAGNTPSRRLYEKLGFRKIDE 82
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 3-165 4.85e-05

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 41.91  E-value: 4.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819989   3 TLRAFTCDDLFRFNNINLDPLTETYGIP----------FYLQYLAHWPE----YFIVAEAPGGELMGYskysttstflvm 68
Cdd:COG1670    9 RLRPLRPEDAEALAELLNDPEVARYLPGppysleearaWLERLLADWADggalPFAIEDKEDGELIGV------------ 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819989  69 gkaeGSVAREEWHGHVT--ALSVAPEFRRLGLAAKLMELLEEISERKGGF-FVDLFVRVSNQVAVNMYKQLGYSVYRTVI 145
Cdd:COG1670   77 ----VGLYDIDRANRSAeiGYWLAPAYWGKGYATEALRALLDYAFEELGLhRVEAEVDPDNTASIRVLEKLGFRLEGTLR 152

                        170       180
                 ....*....|....*....|
gi 157819989 146 EYYSASNGEPDEDAYDMRKA 165
Cdd:COG1670  153 DALVIDGRYRDHVLYSLLRE 172
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 43-120 5.11e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 39.57  E-value: 5.11e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157819989  43 FIVAEApGGELMGYskysttstflVMGKAEGSVAReewHGHVTALSVAPEFRRLGLAAKLMELLEEISERKGGFFVDL 120
Cdd:cd04301    1 FLVAED-DGEIVGF----------ASLSPDGSGGD---TAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRL 64
Eis COG4552
Predicted acetyltransferase [General function prediction only];
82-112 2.00e-03

Predicted acetyltransferase [General function prediction only];


Pssm-ID: 443616 [Multi-domain]  Cd Length: 393  Bit Score: 37.96  E-value: 2.00e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 157819989  82 GHVTALSVAPEFRRLGLAAKLM-ELLEEISER 112
Cdd:COG4552   73 AGITGVAVAPEHRRRGVARALLrEALAELRER 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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