interleukin-1 family member 10 [Rattus norvegicus]
List of domain hits
Name | Accession | Description | Interval | E-value | |||
beta-trefoil_IL1 super family | cl00094 | beta-trefoil domain found in the interleukin-1 (IL-1) family of cytokines; The IL-1 family of ... |
3-151 | 1.76e-110 | |||
beta-trefoil domain found in the interleukin-1 (IL-1) family of cytokines; The IL-1 family of cytokines comprises 11 members, including 7 pro-inflammatory agonists (IL-1alpha, IL-1beta, IL-18, IL-33, IL-36alpha, IL-36beta, IL-36gamma) and 4 defined or putative antagonists (IL-1R antagonist (IL-1Ra), IL-36Ra, IL-37, and IL-38) exerting anti-inflammatory activities. These members can have complimentary or distinct biological functions. All family members share a common structure at the C-terminus, which is comprised by of a typical beta-trefoil fold consisting of 12-beta-strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The actual alignment was detected with superfamily member cd23302: Pssm-ID: 469612 Cd Length: 149 Bit Score: 310.05 E-value: 1.76e-110
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Name | Accession | Description | Interval | E-value | |||
beta-trefoil_IL38 | cd23302 | beta-trefoil domain found in interleukin-38 (IL-38) and similar proteins; IL-38, also called ... |
3-151 | 1.76e-110 | |||
beta-trefoil domain found in interleukin-38 (IL-38) and similar proteins; IL-38, also called interleukin-1 family member 10, or IL-1F10, or family of interleukin 1-theta, or FIL1 theta, or interleukin-1 HY2, or IL-1HY2, or interleukin-1 theta, or IL-1 theta, acts as cytokine with immunomodulatory activity. Alone, it does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. It also reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. It increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). IL-38 contains a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Pssm-ID: 466784 Cd Length: 149 Bit Score: 310.05 E-value: 1.76e-110
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IL1 | smart00125 | Interleukin-1 homologues; Cytokines with various biological functions. Interluekin 1 alpha and ... |
10-149 | 7.44e-29 | |||
Interleukin-1 homologues; Cytokines with various biological functions. Interluekin 1 alpha and beta are also known as hematopoietin and catabolin. Pssm-ID: 128430 Cd Length: 147 Bit Score: 103.23 E-value: 7.44e-29
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IL1 | pfam00340 | Interleukin-1 / 18; This family includes interleukin-1 and interleukin-18. |
34-148 | 2.61e-21 | |||
Interleukin-1 / 18; This family includes interleukin-1 and interleukin-18. Pssm-ID: 395269 Cd Length: 119 Bit Score: 82.88 E-value: 2.61e-21
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PHA02651 | PHA02651 | IL-1 receptor antagonist; Provisional |
10-150 | 3.13e-13 | |||
IL-1 receptor antagonist; Provisional Pssm-ID: 165031 Cd Length: 165 Bit Score: 63.13 E-value: 3.13e-13
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Name | Accession | Description | Interval | E-value | |||
beta-trefoil_IL38 | cd23302 | beta-trefoil domain found in interleukin-38 (IL-38) and similar proteins; IL-38, also called ... |
3-151 | 1.76e-110 | |||
beta-trefoil domain found in interleukin-38 (IL-38) and similar proteins; IL-38, also called interleukin-1 family member 10, or IL-1F10, or family of interleukin 1-theta, or FIL1 theta, or interleukin-1 HY2, or IL-1HY2, or interleukin-1 theta, or IL-1 theta, acts as cytokine with immunomodulatory activity. Alone, it does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. It also reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. It increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). IL-38 contains a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Pssm-ID: 466784 Cd Length: 149 Bit Score: 310.05 E-value: 1.76e-110
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beta-trefoil_IL36RA | cd23303 | beta-trefoil domain found in interleukin-36 receptor antagonist protein (IL-36RA) and similar ... |
10-150 | 4.50e-53 | |||
beta-trefoil domain found in interleukin-36 receptor antagonist protein (IL-36RA) and similar proteins; IL-36RA, also called FIL1 delta, or IL-1-related protein 3, or IL-1RP3, or interleukin-1 HY1, or IL-1HY1, or interleukin-1 delta, or IL-1 delta, or interleukin-1 family member 5, or IL-1F5, or interleukin-1 receptor antagonist homolog 1, or IL-1ra homolog 1, or interleukin-1-like protein 1, or IL-1L1, inhibits the activity of interleukin-36 (IL36 alpha,IL36 beta and IL36 gamma) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. It is part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; like the IL-1 system with which it shares the coreceptor. It may play a role in skin inflammation, as well as in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. It may activate an anti-inflammatory signaling pathway by recruiting SIGIRR. IL-36RA contains a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Pssm-ID: 466785 Cd Length: 146 Bit Score: 164.91 E-value: 4.50e-53
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beta-trefoil_IL1RA | cd23297 | beta-trefoil domain found in interleukin-1 receptor antagonist protein (IL-1RA) and similar ... |
10-149 | 7.29e-49 | |||
beta-trefoil domain found in interleukin-1 receptor antagonist protein (IL-1RA) and similar proteins; IL-1RA, also called IL-1RN, or IRAP, or ICIL-1RA, or IL1 inhibitor, inhibits the activity of interleukin-1 (IL-1) by binding to receptor IL1R1 and preventing its association with the co-receptor IL1RAP for signaling. It has no IL-1 like activity. IL-1RN binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unknown. IL-1RN contains a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Pssm-ID: 466779 Cd Length: 149 Bit Score: 154.14 E-value: 7.29e-49
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beta-trefoil_IL1 | cd00100 | beta-trefoil domain found in the interleukin-1 (IL-1) family of cytokines; The IL-1 family of ... |
6-148 | 2.31e-47 | |||
beta-trefoil domain found in the interleukin-1 (IL-1) family of cytokines; The IL-1 family of cytokines comprises 11 members, including 7 pro-inflammatory agonists (IL-1alpha, IL-1beta, IL-18, IL-33, IL-36alpha, IL-36beta, IL-36gamma) and 4 defined or putative antagonists (IL-1R antagonist (IL-1Ra), IL-36Ra, IL-37, and IL-38) exerting anti-inflammatory activities. These members can have complimentary or distinct biological functions. All family members share a common structure at the C-terminus, which is comprised by of a typical beta-trefoil fold consisting of 12-beta-strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Pssm-ID: 466776 Cd Length: 145 Bit Score: 150.16 E-value: 2.31e-47
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IL1 | smart00125 | Interleukin-1 homologues; Cytokines with various biological functions. Interluekin 1 alpha and ... |
10-149 | 7.44e-29 | |||
Interleukin-1 homologues; Cytokines with various biological functions. Interluekin 1 alpha and beta are also known as hematopoietin and catabolin. Pssm-ID: 128430 Cd Length: 147 Bit Score: 103.23 E-value: 7.44e-29
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beta-trefoil_IL36 | cd23300 | beta-trefoil domain found in the family of interleukin-36 (IL-36) and similar proteins; The ... |
10-150 | 1.41e-27 | |||
beta-trefoil domain found in the family of interleukin-36 (IL-36) and similar proteins; The IL-36 family includes three members, IL-36 alpha (also called FIL1 epsilon, or interleukin-1 epsilon, or IL-1 epsilon, or interleukin-1 family member 6, or IL-1F6), IL-36 beta (also called FIL1 eta, or interleukin-1 eta, or IL-1 eta, or interleukin-1 family member 8, or IL-1F8, or interleukin-1 homolog 2, or IL-1H2), and IL-36 gamma (also called IL-1-related protein 2, or IL-1RP2, or interleukin-1 epsilon, or IL-1 epsilon, or interleukin-1 family member 9, or IL-1F9, or interleukin-1 homolog 1, or IL-1H1). They act as cytokines that bind to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. They are parts of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; like the IL-1 system with which they share the co-receptor IL1RAP. They may be involved in skin inflammatory response by acting on keratinocytes, dendritic cells, and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. Members in this family contain a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Pssm-ID: 466782 Cd Length: 148 Bit Score: 100.06 E-value: 1.41e-27
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beta-trefoil_IL37 | cd23301 | beta-trefoil domain found in interleukin-37 (IL-37) and similar proteins; IL-37, also called ... |
10-149 | 6.83e-25 | |||
beta-trefoil domain found in interleukin-37 (IL-37) and similar proteins; IL-37, also called FIL1 zeta, or IL-1X, or interleukin-1 family member 7, or IL-1F7, or interleukin-1 homolog 4, or IL-1H, or IL-1H4, or interleukin-1 zeta, or IL-1 zeta, or interleukin-1-related protein, or IL-1RP1, or interleukin-23, or IL-23, acts as a suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. It suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A, and IL1RN, but spares anti-inflammatory cytokines and inhibits dendritic cell activation. IL-37 contains a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Pssm-ID: 466783 Cd Length: 151 Bit Score: 93.26 E-value: 6.83e-25
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IL1 | pfam00340 | Interleukin-1 / 18; This family includes interleukin-1 and interleukin-18. |
34-148 | 2.61e-21 | |||
Interleukin-1 / 18; This family includes interleukin-1 and interleukin-18. Pssm-ID: 395269 Cd Length: 119 Bit Score: 82.88 E-value: 2.61e-21
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beta-trefoil_IL1B | cd23296 | beta-trefoil domain found in interleukin-1 beta (IL-1 beta) and similar proteins; IL-1 beta, ... |
53-147 | 4.11e-20 | |||
beta-trefoil domain found in interleukin-1 beta (IL-1 beta) and similar proteins; IL-1 beta, also called catabolin, is a potent inflammatory cytokine that activates the inflammatory process. It was initially discovered as the major endogenous pyrogen. It induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. IL-1 beta promotes Th17 differentiation of T-cells and synergizes with IL12/interleukin-12 to induce IFN-gamma synthesis from T-helper 1 (Th1) cells. It plays a role in angiogenesis by inducing vascular endothelial growth factor (VEGF) production synergistically with tumor necrosis factor (TNF) and IL-6. IL-1 beta contains a C-terminal beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. Pssm-ID: 466778 Cd Length: 150 Bit Score: 80.74 E-value: 4.11e-20
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PHA02651 | PHA02651 | IL-1 receptor antagonist; Provisional |
10-150 | 3.13e-13 | |||
IL-1 receptor antagonist; Provisional Pssm-ID: 165031 Cd Length: 165 Bit Score: 63.13 E-value: 3.13e-13
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Blast search parameters | ||||
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