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Conserved domains on  [gi|157823934|ref|NP_001101940|]
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myeloid zinc finger 1 [Rattus norvegicus]

Protein Classification

C2H2-type zinc finger protein; zinc finger and BTB domain-containing protein( domain architecture ID 12210801)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation| zinc finger and BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) domain-containing protein may be involved in transcriptional regulation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SCAN smart00431
leucine rich region;
41-153 4.95e-56

leucine rich region;


:

Pssm-ID: 128708 [Multi-domain]  Cd Length: 113  Bit Score: 186.74  E-value: 4.95e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823934    41 PEAARLRFRCFRYEEAIGPQEALAQLRELCHQWLRPEVHSKEQILELLVLEQFLGALPSEIQARVQEQWPGSPEEAAALV 120
Cdd:smart00431   1 PEIFRQRFRQFRYQETSGPREALSRLRELCRQWLRPELHTKEQILELLVLEQFLTILPGELQAWVREHHPESGEEAVTLL 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 157823934   121 DRLRWELDGPRKWVTVQVQGKEVLSEKMEPSSF 153
Cdd:smart00431  81 EDLERELDEPGQQVSAHVHGQEVLLEKMVPLGA 113
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
358-717 2.14e-15

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 79.35  E-value: 2.14e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823934 358 RCDVCGKVFSQRSNLLRHQKIHTGERPFVCGECGR--SFSRSSHLLRHQLTHTEERPFVCRDCGQGFVRSARLEE----- 430
Cdd:COG5048   35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSlssss 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823934 431 -HRRVHTGEQP--------------------FRCAECGQSFRQRSNLLQHQRIHGD-----PPGPAPPVRSLAGVPEPPG 484
Cdd:COG5048  115 sNSNDNNLLSShslppssrdpqlpdllsisnLRNNPLPGNNSSSVNTPQSNSLHPPlpansLSKDPSSNLSLLISSNVST 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823934 485 PFPCSECCeSFPRRAVLLEHQA-VHTGDKSFGCVECGERFGR---RSVLLQHRRVHSGERPFACAECGQSFRQRSNLTQH 560
Cdd:COG5048  195 SIPSSSEN-SPLSSSYSIPSSSsDQNLENSSSSLPLTTNSQLspkSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSS 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823934 561 RRIHTGER-------PFACTECGKAFRQRPTLTQHLR--VHTGE--KPFACPE--CGQRFSQRLKLTRHQRTHTGEKPYR 627
Cdd:COG5048  274 SPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAK 353

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823934 628 CSECGLGFTQVSRLTE-------HQRIHTGERPFAC--PECGQSFRQHANLIQHRRIHTGERPYAC--PECGKAFRQRPT 696
Cdd:COG5048  354 EKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYN 433

                        410       420
                 ....*....|....*....|.
gi 157823934 697 LTQHLRTHRREKPFACQDCGR 717
Cdd:COG5048  434 LIPHKKIHTNHAPLLCSILKS 454
 
Name Accession Description Interval E-value
SCAN smart00431
leucine rich region;
41-153 4.95e-56

leucine rich region;


Pssm-ID: 128708 [Multi-domain]  Cd Length: 113  Bit Score: 186.74  E-value: 4.95e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823934    41 PEAARLRFRCFRYEEAIGPQEALAQLRELCHQWLRPEVHSKEQILELLVLEQFLGALPSEIQARVQEQWPGSPEEAAALV 120
Cdd:smart00431   1 PEIFRQRFRQFRYQETSGPREALSRLRELCRQWLRPELHTKEQILELLVLEQFLTILPGELQAWVREHHPESGEEAVTLL 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 157823934   121 DRLRWELDGPRKWVTVQVQGKEVLSEKMEPSSF 153
Cdd:smart00431  81 EDLERELDEPGQQVSAHVHGQEVLLEKMVPLGA 113
SCAN pfam02023
SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found ...
 41-129 2.00e-44

SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several pfam00096 proteins. The domain has been shown to be able to mediate homo- and hetero-oligomerization.


Pssm-ID: 460417 [Multi-domain]  Cd Length: 89  Bit Score: 154.18  E-value: 2.00e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823934   41 PEAARLRFRCFRYEEAIGPQEALAQLRELCHQWLRPEVHSKEQILELLVLEQFLGALPSEIQARVQEQWPGSPEEAAALV 120
Cdd:pfam02023   1 PEASRQRFRQFCYQEAEGPREALSQLRELCHQWLRPEKHTKEQILELLVLEQFLTILPEEIQSWVREHHPESGEEAVALA 80


                  ....*....
gi 157823934  121 DRLRWELDG 129
Cdd:pfam02023  81 EDLLLERGE 89
SCAN cd07936
SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 ...
 41-124 2.67e-38

SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several vertebrate proteins that contain C2H2 zinc finger motifs, many of which may be transcription factors playing roles in cell survival and differentiation. This protein-interaction domain is able to mediate homo- and hetero-oligomerization of SCAN-containing proteins. Some SCAN-containing proteins, including those of lower vertebrates, do not contain zinc finger motifs. It has been noted that the SCAN domain resembles a domain-swapped version of the C-terminal domain of the HIV capsid protein. This domain model features elements common to the three general groups of SCAN domains (SCAN-A1, SCAN-A2, and SCAN-B). The SCAND1 protein is truncated at the C-terminus with respect to this model, the SCAND2 protein appears to have a truncated central helix.


Pssm-ID: 153421  Cd Length: 85  Bit Score: 137.01  E-value: 2.67e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823934  41 PEAARLRFRCFRYEEAIGPQEALAQLRELCHQWLRPEVHSKEQILELLVLEQFLGALPSEIQARVQEQWPGSPEEAAALV 120
Cdd:cd07936    1 PETYRQRFRAFQYQEASGPREALQRLRELCRQWLRPEIHTKEQILELLVLEQFLIILPPEVQAWVRERKPESGEEAATLA 80


                 ....
gi 157823934 121 DRLR 124
Cdd:cd07936   81 EDLL 84
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
358-717 2.14e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 79.35  E-value: 2.14e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823934 358 RCDVCGKVFSQRSNLLRHQKIHTGERPFVCGECGR--SFSRSSHLLRHQLTHTEERPFVCRDCGQGFVRSARLEE----- 430
Cdd:COG5048   35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSlssss 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823934 431 -HRRVHTGEQP--------------------FRCAECGQSFRQRSNLLQHQRIHGD-----PPGPAPPVRSLAGVPEPPG 484
Cdd:COG5048  115 sNSNDNNLLSShslppssrdpqlpdllsisnLRNNPLPGNNSSSVNTPQSNSLHPPlpansLSKDPSSNLSLLISSNVST 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823934 485 PFPCSECCeSFPRRAVLLEHQA-VHTGDKSFGCVECGERFGR---RSVLLQHRRVHSGERPFACAECGQSFRQRSNLTQH 560
Cdd:COG5048  195 SIPSSSEN-SPLSSSYSIPSSSsDQNLENSSSSLPLTTNSQLspkSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSS 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823934 561 RRIHTGER-------PFACTECGKAFRQRPTLTQHLR--VHTGE--KPFACPE--CGQRFSQRLKLTRHQRTHTGEKPYR 627
Cdd:COG5048  274 SPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAK 353

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823934 628 CSECGLGFTQVSRLTE-------HQRIHTGERPFAC--PECGQSFRQHANLIQHRRIHTGERPYAC--PECGKAFRQRPT 696
Cdd:COG5048  354 EKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYN 433

                        410       420
                 ....*....|....*....|.
gi 157823934 697 LTQHLRTHRREKPFACQDCGR 717
Cdd:COG5048  434 LIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
668-693 5.82e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 5.82e-06
                          10        20
                  ....*....|....*....|....*.
gi 157823934  668 NLIQHRRIHTGERPYACPECGKAFRQ 693
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 653-701 1.88e-04

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 41.78  E-value: 1.88e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 157823934 653 PFACPECGQSFRQHANLIQHrrIHTGERPYACPECGKAFRQRPTLTQHL 701
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQH--IRYTEHSKVCPVCGKEFRNTDSTLDHV 119
transpos_ISL3 NF033550
ISL3 family transposase;
646-731 3.72e-03

ISL3 family transposase;


Pssm-ID: 468079 [Multi-domain]  Cd Length: 369  Bit Score: 40.26  E-value: 3.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823934 646 RIHTGERPFACPECGQsfrqhanliQHRRIH-TGERPYACPECGkafrQRPTLTqHLRTHRrekpFACQDCGRRFHQSTK 724
Cdd:NF033550   3 EAELTRGDATCPECGK---------PSRRVHdTGKRRIRHLPIF----GRPVYL-ELRVRR----FKCPECGKTFTEELP 64


                 ....*...
gi 157823934 725 LIQ-HQRI 731
Cdd:NF033550  65 WARkRSRI 72
 
Name Accession Description Interval E-value
SCAN smart00431
leucine rich region;
41-153 4.95e-56

leucine rich region;


Pssm-ID: 128708 [Multi-domain]  Cd Length: 113  Bit Score: 186.74  E-value: 4.95e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823934    41 PEAARLRFRCFRYEEAIGPQEALAQLRELCHQWLRPEVHSKEQILELLVLEQFLGALPSEIQARVQEQWPGSPEEAAALV 120
Cdd:smart00431   1 PEIFRQRFRQFRYQETSGPREALSRLRELCRQWLRPELHTKEQILELLVLEQFLTILPGELQAWVREHHPESGEEAVTLL 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 157823934   121 DRLRWELDGPRKWVTVQVQGKEVLSEKMEPSSF 153
Cdd:smart00431  81 EDLERELDEPGQQVSAHVHGQEVLLEKMVPLGA 113
SCAN pfam02023
SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found ...
 41-129 2.00e-44

SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several pfam00096 proteins. The domain has been shown to be able to mediate homo- and hetero-oligomerization.


Pssm-ID: 460417 [Multi-domain]  Cd Length: 89  Bit Score: 154.18  E-value: 2.00e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823934   41 PEAARLRFRCFRYEEAIGPQEALAQLRELCHQWLRPEVHSKEQILELLVLEQFLGALPSEIQARVQEQWPGSPEEAAALV 120
Cdd:pfam02023   1 PEASRQRFRQFCYQEAEGPREALSQLRELCHQWLRPEKHTKEQILELLVLEQFLTILPEEIQSWVREHHPESGEEAVALA 80


                  ....*....
gi 157823934  121 DRLRWELDG 129
Cdd:pfam02023  81 EDLLLERGE 89
SCAN cd07936
SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 ...
 41-124 2.67e-38

SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several vertebrate proteins that contain C2H2 zinc finger motifs, many of which may be transcription factors playing roles in cell survival and differentiation. This protein-interaction domain is able to mediate homo- and hetero-oligomerization of SCAN-containing proteins. Some SCAN-containing proteins, including those of lower vertebrates, do not contain zinc finger motifs. It has been noted that the SCAN domain resembles a domain-swapped version of the C-terminal domain of the HIV capsid protein. This domain model features elements common to the three general groups of SCAN domains (SCAN-A1, SCAN-A2, and SCAN-B). The SCAND1 protein is truncated at the C-terminus with respect to this model, the SCAND2 protein appears to have a truncated central helix.


Pssm-ID: 153421  Cd Length: 85  Bit Score: 137.01  E-value: 2.67e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823934  41 PEAARLRFRCFRYEEAIGPQEALAQLRELCHQWLRPEVHSKEQILELLVLEQFLGALPSEIQARVQEQWPGSPEEAAALV 120
Cdd:cd07936    1 PETYRQRFRAFQYQEASGPREALQRLRELCRQWLRPEIHTKEQILELLVLEQFLIILPPEVQAWVRERKPESGEEAATLA 80


                 ....
gi 157823934 121 DRLR 124
Cdd:cd07936   81 EDLL 84
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
358-717 2.14e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 79.35  E-value: 2.14e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823934 358 RCDVCGKVFSQRSNLLRHQKIHTGERPFVCGECGR--SFSRSSHLLRHQLTHTEERPFVCRDCGQGFVRSARLEE----- 430
Cdd:COG5048   35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSlssss 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823934 431 -HRRVHTGEQP--------------------FRCAECGQSFRQRSNLLQHQRIHGD-----PPGPAPPVRSLAGVPEPPG 484
Cdd:COG5048  115 sNSNDNNLLSShslppssrdpqlpdllsisnLRNNPLPGNNSSSVNTPQSNSLHPPlpansLSKDPSSNLSLLISSNVST 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823934 485 PFPCSECCeSFPRRAVLLEHQA-VHTGDKSFGCVECGERFGR---RSVLLQHRRVHSGERPFACAECGQSFRQRSNLTQH 560
Cdd:COG5048  195 SIPSSSEN-SPLSSSYSIPSSSsDQNLENSSSSLPLTTNSQLspkSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSS 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823934 561 RRIHTGER-------PFACTECGKAFRQRPTLTQHLR--VHTGE--KPFACPE--CGQRFSQRLKLTRHQRTHTGEKPYR 627
Cdd:COG5048  274 SPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAK 353

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823934 628 CSECGLGFTQVSRLTE-------HQRIHTGERPFAC--PECGQSFRQHANLIQHRRIHTGERPYAC--PECGKAFRQRPT 696
Cdd:COG5048  354 EKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYN 433

                        410       420
                 ....*....|....*....|.
gi 157823934 697 LTQHLRTHRREKPFACQDCGR 717
Cdd:COG5048  434 LIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
383-732 5.36e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.41  E-value: 5.36e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823934 383 RPFVCGECGRSFSRSSHLLRHQLTHTEERPFVCRDCGQGFVRSARLEEHRRV--HTGEQPFRCAECGQSFRQR------- 453
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLrtHHNNPSDLNSKSLPLSNSKassssls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823934 454 -----SNLLQHQRIHGDPP----GPAPPVRS---LAGVPEPPGPFPCSECCESFPRRAVLLEHqavhtgdksfgcVECGE 521
Cdd:COG5048  112 ssssnSNDNNLLSSHSLPPssrdPQLPDLLSisnLRNNPLPGNNSSSVNTPQSNSLHPPLPAN------------SLSKD 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823934 522 RFGRRSVLLQHRrVHSGERPFACAECGQSFRQRSNLTQHRRIHTGERPFACTECGkaFRQRPTLTQHLRVHTGEKPFACP 601
Cdd:COG5048  180 PSSNLSLLISSN-VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS--QLSPKSLLSQSPSSLSSSDSSSS 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823934 602 ECGQRFSQRLKLTRHQRTHTgekpYRCSEcglgftqvsrltEHQRIHTgerPFACPECGQSFRQHANLIQHRR--IHTGE 679
Cdd:COG5048  257 ASESPRSSLPTASSQSSSPN----ESDSS------------SEKGFSL---PIKSKQCNISFSRSSPLTRHLRsvNHSGE 317

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 157823934 680 --RPYACPE--CGKAFRQRPTLTQHLRTHRREKPFACQDCGRRFHQSTKLIQ--HQRIH 732
Cdd:COG5048  318 slKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNepPQSLQ 376
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
364-557 2.02e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 2.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823934 364 KVFSQRSNLLRHQKIHTGER-PFVCGECGRSFSRSSHLLRHQLT--HTEE--RPFVCR--DCGQGFVRSARLEEHRRVHT 436
Cdd:COG5048  268 ASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHT 347

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823934 437 GEQPFRC--AECGQSFRQRSNLLQHQRIHGDPpgpaPPVRSLAGVPEPPGpfpcseCCESFPRRAVLLEHQAVHTGDKS- 513
Cdd:COG5048  348 SISPAKEklLNSSSKFSPLLNNEPPQSLQQYK----DLKNDKKSETLSNS------CIRNFKRDSNLSLHIITHLSFRPy 417

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 157823934 514 -FGCVECGERFGRRSVLLQHRRVHSGERPFACAECGqSFRQRSNL 557
Cdd:COG5048  418 nCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILK-SFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
668-693 5.82e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 5.82e-06
                          10        20
                  ....*....|....*....|....*.
gi 157823934  668 NLIQHRRIHTGERPYACPECGKAFRQ 693
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
556-581 1.55e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 1.55e-05
                          10        20
                  ....*....|....*....|....*.
gi 157823934  556 NLTQHRRIHTGERPFACTECGKAFRQ 581
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
585-609 4.01e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 4.01e-05
                          10        20
                  ....*....|....*....|....*
gi 157823934  585 LTQHLRVHTGEKPFACPECGQRFSQ 609
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
613-637 6.23e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 6.23e-05
                          10        20
                  ....*....|....*....|....*
gi 157823934  613 LTRHQRTHTGEKPYRCSECGLGFTQ 637
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
640-665 7.89e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 7.89e-05
                          10        20
                  ....*....|....*....|....*.
gi 157823934  640 RLTEHQRIHTGERPFACPECGQSFRQ 665
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 385-407 9.21e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.98  E-value: 9.21e-05
                          10        20
                  ....*....|....*....|...
gi 157823934  385 FVCGECGRSFSRSSHLLRHQLTH 407
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
PHA00733 PHA00733
hypothetical protein
 653-701 1.88e-04

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 41.78  E-value: 1.88e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 157823934 653 PFACPECGQSFRQHANLIQHrrIHTGERPYACPECGKAFRQRPTLTQHL 701
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQH--IRYTEHSKVCPVCGKEFRNTDSTLDHV 119
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 358-379 2.53e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.44  E-value: 2.53e-04
                          10        20
                  ....*....|....*....|..
gi 157823934  358 RCDVCGKVFSQRSNLLRHQKIH 379
Cdd:pfam00096   2 KCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 441-463 4.05e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.05  E-value: 4.05e-04
                          10        20
                  ....*....|....*....|...
gi 157823934  441 FRCAECGQSFRQRSNLLQHQRIH 463
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
680-733 4.46e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 4.46e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 157823934 680 RPYACPECGKAFRQRPTLTQHLRTHRREKPFACQDCGRRFHQST--KLIQHQRIHS 733
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHH 87
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
603-677 5.54e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 5.54e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157823934 603 CGQRFSQRLKLTRHQRTHTgEKPYRCSECGLGFTQVSRLTEHQRIHTGERPFAC--PECGQSFRQHANLIQHRRIHT 677
Cdd:COG5048   12 NNSVLSSTPKSTLKSLSNA-PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHH 87
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 682-704 7.15e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 7.15e-04
                          10        20
                  ....*....|....*....|...
gi 157823934  682 YACPECGKAFRQRPTLTQHLRTH 704
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
427-452 8.90e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.90e-04
                          10        20
                  ....*....|....*....|....*.
gi 157823934  427 RLEEHRRVHTGEQPFRCAECGQSFRQ 452
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 542-564 1.13e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 1.13e-03
                          10        20
                  ....*....|....*....|...
gi 157823934  542 FACAECGQSFRQRSNLTQHRRIH 564
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 654-676 1.48e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.48e-03
                          10        20
                  ....*....|....*....|...
gi 157823934  654 FACPECGQSFRQHANLIQHRRIH 676
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 598-620 1.87e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.87e-03
                          10        20
                  ....*....|....*....|...
gi 157823934  598 FACPECGQRFSQRLKLTRHQRTH 620
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 570-592 3.14e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 3.14e-03
                          10        20
                  ....*....|....*....|...
gi 157823934  570 FACTECGKAFRQRPTLTQHLRVH 592
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
transpos_ISL3 NF033550
ISL3 family transposase;
646-731 3.72e-03

ISL3 family transposase;


Pssm-ID: 468079 [Multi-domain]  Cd Length: 369  Bit Score: 40.26  E-value: 3.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823934 646 RIHTGERPFACPECGQsfrqhanliQHRRIH-TGERPYACPECGkafrQRPTLTqHLRTHRrekpFACQDCGRRFHQSTK 724
Cdd:NF033550   3 EAELTRGDATCPECGK---------PSRRVHdTGKRRIRHLPIF----GRPVYL-ELRVRR----FKCPECGKTFTEELP 64


                 ....*...
gi 157823934 725 LIQ-HQRI 731
Cdd:NF033550  65 WARkRSRI 72
COG2331 COG2331
Predicted nucleic acid-binding protein, contains Zn-ribbon domain [General function prediction ...
 626-665 8.29e-03

Predicted nucleic acid-binding protein, contains Zn-ribbon domain [General function prediction only];


Pssm-ID: 441902  Cd Length: 77  Bit Score: 35.79  E-value: 8.29e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 157823934 626 YRCSECGLGFTQVSRLTEHQRIHtgerpfaCPECGQSFRQ 665
Cdd:COG2331    6 YRCESCGHEFEVLQKMSDDPLTV-------CPECGGPLRR 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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