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Conserved domains on  [gi|157817386|ref|NP_001101685|]
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major facilitator superfamily domain-containing protein 9 [Rattus norvegicus]

Protein Classification

major facilitator superfamily domain-containing protein 9( domain architecture ID 13024407)

major facilitator superfamily domain-containing protein 9 may facilitate the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 39-453 5.71e-141

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 408.15  E-value: 5.71e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  39 LYLVGFLDLFGVSMTVPLLNLHVRSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSALGYLLLGM 118
Cdd:cd17390    1 LYLVGFLDLFGVSMILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 119 STNVFLFTLARVPVGVFKHTLSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDGGFYVTAFMCCSVF 198
Cdd:cd17390   81 STSLALLFLSRIPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDGGFYYVALLCSAIF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 199 LLNAGLVWLLPwretslnipdsgwsldqkhatvtiksestlqgaattpearrsgrnlrppwvevmstlkdmknlifSALW 278
Cdd:cd17390  161 ILNAGLVWFLL-----------------------------------------------------------------SKLW 175

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 279 DVFLVRLLMGVAVMLYYSNFVLALEERFGVRPKTTGYLISYTSALGTLAGFAVGPILRLYKHNSHMVLLHSSALTCLLLL 358
Cdd:cd17390  176 DLLLVRFLMGFSVLLFRSNFSLYLEERFDLSPKTIGYLISYSGVLGALSGFLVGRILKLYKNNEYLLLLHSFILLALSLL 255

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 359 LYSTTNSMAMVVLSSTLLSFSTTIGRTCITDLQLSVGGAQASGTVIGVGQSVTAVGRILAPLLSGLAQEISPCGPPSLGA 438
Cdd:cd17390  256 GLALAPSIWLLVLCLTPLSISSAVLRTCSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGLLQEFSVSGPGLLGA 335

                        410
                 ....*....|....*
gi 157817386 439 ALALVAILIMTLYRP 453
Cdd:cd17390  336 VLALAAILLMLARQR 350
 
Name Accession Description Interval E-value
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 39-453 5.71e-141

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 408.15  E-value: 5.71e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  39 LYLVGFLDLFGVSMTVPLLNLHVRSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSALGYLLLGM 118
Cdd:cd17390    1 LYLVGFLDLFGVSMILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 119 STNVFLFTLARVPVGVFKHTLSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDGGFYVTAFMCCSVF 198
Cdd:cd17390   81 STSLALLFLSRIPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDGGFYYVALLCSAIF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 199 LLNAGLVWLLPwretslnipdsgwsldqkhatvtiksestlqgaattpearrsgrnlrppwvevmstlkdmknlifSALW 278
Cdd:cd17390  161 ILNAGLVWFLL-----------------------------------------------------------------SKLW 175

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 279 DVFLVRLLMGVAVMLYYSNFVLALEERFGVRPKTTGYLISYTSALGTLAGFAVGPILRLYKHNSHMVLLHSSALTCLLLL 358
Cdd:cd17390  176 DLLLVRFLMGFSVLLFRSNFSLYLEERFDLSPKTIGYLISYSGVLGALSGFLVGRILKLYKNNEYLLLLHSFILLALSLL 255

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 359 LYSTTNSMAMVVLSSTLLSFSTTIGRTCITDLQLSVGGAQASGTVIGVGQSVTAVGRILAPLLSGLAQEISPCGPPSLGA 438
Cdd:cd17390  256 GLALAPSIWLLVLCLTPLSISSAVLRTCSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGLLQEFSVSGPGLLGA 335

                        410
                 ....*....|....*
gi 157817386 439 ALALVAILIMTLYRP 453
Cdd:cd17390  336 VLALAAILLMLARQR 350
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
33-418 2.48e-19

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 88.88  E-value: 2.48e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  33 RRFLLWLYLVGFLDLFGVSMTVPLLNLHVRSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSALG 112
Cdd:COG2814    9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 113 YLLLGMSTNVFLFTLARVPVGVFKHTL-SISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDG---GFY 188
Cdd:COG2814   89 SLLCALAPSLWLLLAARFLQGLGAGALfPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGwrwVFL 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 189 VTAFMCCSVFLLnagLVWLLPwretslnipdsgwsldqkhatvtiksestlqgaATTPEARRSGRNlrppwvEVMSTLKD 268
Cdd:COG2814  169 VNAVLALLALLL---LLRLLP---------------------------------ESRPAARARLRG------SLRELLRR 206

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 269 mknlifSALWDVFLVRLLMGVAVMLYYSNFVLALEERFGVRPKTTGYLISYTSALGTLAGFAVGPILRlyKHNSHMVLLH 348
Cdd:COG2814  207 ------PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLAD--RFGRRRLLLI 278

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 349 SSALTCLLLLLYSTTNSMAMVVLSSTLLSFSTTIGRTCITDLQLSVGGAQASGTVIGVGQSVTAVGRILA 418
Cdd:COG2814  279 GLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
MFS_1 pfam07690
Major Facilitator Superfamily;
39-419 7.81e-19

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 87.47  E-value: 7.81e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386   39 LYLVGFLDLFGVSMTVPLLNLHV-RSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSALGYLLLG 117
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLaEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  118 MSTNVFLFTLARVPVGVFK-HTLSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDGgfYVTAFMCCS 196
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAgALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG--WRAAFLILA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  197 VFLLNAGLVWLLPwretslnipdsgwsldqkhatvtiksestlqgaaTTPEARRSGRNLRPPWVEVMSTLKDmknlIFSA 276
Cdd:pfam07690 159 ILSLLAAVLLLLP----------------------------------RPPPESKRPKPAEEARLSLIVAWKA----LLRD 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  277 LWDVFLVRLLMGVAVMLYYSNFVLALEERFGVRPKTTGYLISYTSALGTLAGFAVGPILRLYKHNSHMVLLHSSALTCLL 356
Cdd:pfam07690 201 PVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAAL 280

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157817386  357 L-LLYSTTNSMAMVVLSSTLLSFSTTIGRTCITDLQLSVGGAQASGTVIGVGQSVTAVGRILAP 419
Cdd:pfam07690 281 GlLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
33-200 4.51e-07

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 51.84  E-value: 4.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  33 RRFLLWLYLVGFLDLFGVSMTVPLLNLHVRSLGVSPVVA-----GIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCIL 107
Cdd:PRK09874  13 KRNLTVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSAlnmwsGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSAL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 108 LSALGYLLLGMSTNVFLFTLARVPVGVFKHTLSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTE---LD 184
Cdd:PRK09874  93 GMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADsygLR 172

                        170
                 ....*....|....*.
gi 157817386 185 GGFYVTAFMCCSVFLL 200
Cdd:PRK09874 173 PVFFITASVLFLCFLV 188
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 34-209 6.87e-06

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 48.15  E-value: 6.87e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386   34 RFLLWLYLVGFLDLFGVSMTVPLLNLHVRSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSALGY 113
Cdd:TIGR00710   5 AFALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  114 LLLGMSTNVFLFTLARVPVGVFKHT-LSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDGGFYVTAF 192
Cdd:TIGR00710  85 LGLALSNNIETLLVLRFVQAFGASAgSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAF 164

                         170
                  ....*....|....*..
gi 157817386  193 MCCSVFLLNAGLVWLLP 209
Cdd:TIGR00710 165 LSLAGILLSALIFFILP 181
 
Name Accession Description Interval E-value
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 39-453 5.71e-141

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 408.15  E-value: 5.71e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  39 LYLVGFLDLFGVSMTVPLLNLHVRSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSALGYLLLGM 118
Cdd:cd17390    1 LYLVGFLDLFGVSMILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 119 STNVFLFTLARVPVGVFKHTLSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDGGFYVTAFMCCSVF 198
Cdd:cd17390   81 STSLALLFLSRIPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDGGFYYVALLCSAIF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 199 LLNAGLVWLLPwretslnipdsgwsldqkhatvtiksestlqgaattpearrsgrnlrppwvevmstlkdmknlifSALW 278
Cdd:cd17390  161 ILNAGLVWFLL-----------------------------------------------------------------SKLW 175

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 279 DVFLVRLLMGVAVMLYYSNFVLALEERFGVRPKTTGYLISYTSALGTLAGFAVGPILRLYKHNSHMVLLHSSALTCLLLL 358
Cdd:cd17390  176 DLLLVRFLMGFSVLLFRSNFSLYLEERFDLSPKTIGYLISYSGVLGALSGFLVGRILKLYKNNEYLLLLHSFILLALSLL 255

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 359 LYSTTNSMAMVVLSSTLLSFSTTIGRTCITDLQLSVGGAQASGTVIGVGQSVTAVGRILAPLLSGLAQEISPCGPPSLGA 438
Cdd:cd17390  256 GLALAPSIWLLVLCLTPLSISSAVLRTCSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGLLQEFSVSGPGLLGA 335

                        410
                 ....*....|....*
gi 157817386 439 ALALVAILIMTLYRP 453
Cdd:cd17390  336 VLALAAILLMLARQR 350
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 39-448 2.34e-48

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 169.30  E-value: 2.34e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  39 LYLVGFLDLFGVSMTVPLLNLHVRS---LGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSALGYLL 115
Cdd:cd17330    1 LFLVVFLDALGFGIVFPVLPFYVREfnkLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 116 LGMSTNVFLFTLARVPVGVFKHTLSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDgGFYVTAFMCC 195
Cdd:cd17330   81 LGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPY-GYALPFLVAA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 196 SVFLLNAGLVWLLPWRetslnipdsgwsldqkhatvtiksestlqgaattpearrsgrnlrppwvevmstlkdmknlifs 275
Cdd:cd17330  160 ALALLNLVLVLFFLPP---------------------------------------------------------------- 175

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 276 aLWDVFLVRLLMGVAVMLYYSNFVLALEERFGVRPKTTGYLISYTSALGTLAGFAVGPILRlYKHNSHMVLLHSSALTCL 355
Cdd:cd17330  176 -LRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLA-KRLGERKLLRLGLLLAII 253

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 356 LLLLYSTTNSMAMVVLSSTLLSFSTTIGRTCITDLQLSVGGAQASGTVIGVGQSVTAVGRILAPLLSG-LAQEISPCGPP 434
Cdd:cd17330  254 GLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGpLYSFLGPGVPF 333

                        410
                 ....*....|....
gi 157817386 435 SLGAALALVAILIM 448
Cdd:cd17330  334 LLAAGLLLIALFLL 347
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 35-450 6.93e-35

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 133.88  E-value: 6.93e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  35 FLLWLYLVGFLDLFGVSMTVPLLNLHVRSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSALGYL 114
Cdd:cd17331    1 VLLIVHLNIVLYATCYWLQQPVLPYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 115 LLGMSTNVFLFTLARVPvGVFKHTLSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELdGGFYVTAFMC 194
Cdd:cd17331   81 LLAFASSVPMLFLSRLP-SVFMHAMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKK-FGEQAAALVA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 195 CSVFLLNAGLVWLLpwretslnIPDSgwsldqkhatvtiksestlqgaATTPEARRSGRNLRPPWVEVMSTLKDMknLIF 274
Cdd:cd17331  159 AVGSLLSIVLVILL--------IPSN----------------------TKSKREKEAKESASPPSVFNLKEILRL--LRL 206

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 275 SALWDVFLVRLLMGVAVMLYYSNFVLALEERFGVRPKTTGYLISYTSALGTLA-GFAVGPILRLYKHNShMVLLHSSALT 353
Cdd:cd17331  207 PGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVqGLLVGPLTKRFGERS-LLKLSVALLA 285

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 354 CLLLLLYSTTNSMAMVVLsSTLLSFSTTIGRTCITDLQLSVGGAQASGTVIGVGQSVTAVGRILAPLLSG-LAQEISPCG 432
Cdd:cd17331  286 IGYLLLAFVTTVWQLLVL-LLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGaLLQAYGFPS 364

                        410
                 ....*....|....*...
gi 157817386 433 PPSLGAALALVAILIMTL 450
Cdd:cd17331  365 FGLLGAAINGLLTVYLLL 382
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 39-452 9.09e-26

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 108.05  E-value: 9.09e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  39 LYLVGFLDLFGVSMTVPLLNLHVRSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSALGYLLLGM 118
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 119 STNVFLFTLARVPVGVFKHTLS-ISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELdGGFYVTAFMCCSV 197
Cdd:cd17325   81 ATSYWQLLLARFLQGLASAAVWpAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADA-LGYRAPFLVCAAL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 198 FLLNAGLVWLLPWREtslnipdsgwsldqkhatvtiksestlqgAATTPEARRSGRNLRPPWVEVMStlkdmknliFSAL 277
Cdd:cd17325  160 ALLALVLALLLLPEP-----------------------------RPPPNKRAVSAARLRSGLRLLLR---------DRRL 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 278 WDVFLVRLLMGVAVMLYYSNFVLALEERFGVRPKTTGYLISYTSALGTLAGFAVGPIlrLYKHNSHMVLLHSSALTCLLL 357
Cdd:cd17325  202 LALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKL--SDRIGRKPLILIGLLLSAVAL 279

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 358 LLYSTTNSMAMVVLSSTLLSFSTTIGRTCITDLQLSVGGAQASGTVIGVGQSVTAVGRILAPLLSG-LAQEISPCGPPSL 436
Cdd:cd17325  280 LLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGfLYDAFGFATPFLA 359

                        410
                 ....*....|....*.
gi 157817386 437 GAALALVAILIMTLYR 452
Cdd:cd17325  360 AAALLLLAAVLFLLLR 375
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
33-418 2.48e-19

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 88.88  E-value: 2.48e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  33 RRFLLWLYLVGFLDLFGVSMTVPLLNLHVRSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSALG 112
Cdd:COG2814    9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALG 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 113 YLLLGMSTNVFLFTLARVPVGVFKHTL-SISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDG---GFY 188
Cdd:COG2814   89 SLLCALAPSLWLLLAARFLQGLGAGALfPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGwrwVFL 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 189 VTAFMCCSVFLLnagLVWLLPwretslnipdsgwsldqkhatvtiksestlqgaATTPEARRSGRNlrppwvEVMSTLKD 268
Cdd:COG2814  169 VNAVLALLALLL---LLRLLP---------------------------------ESRPAARARLRG------SLRELLRR 206

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 269 mknlifSALWDVFLVRLLMGVAVMLYYSNFVLALEERFGVRPKTTGYLISYTSALGTLAGFAVGPILRlyKHNSHMVLLH 348
Cdd:COG2814  207 ------PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLAD--RFGRRRLLLI 278

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 349 SSALTCLLLLLYSTTNSMAMVVLSSTLLSFSTTIGRTCITDLQLSVGGAQASGTVIGVGQSVTAVGRILA 418
Cdd:COG2814  279 GLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
MFS_1 pfam07690
Major Facilitator Superfamily;
39-419 7.81e-19

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 87.47  E-value: 7.81e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386   39 LYLVGFLDLFGVSMTVPLLNLHV-RSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSALGYLLLG 117
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLaEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  118 MSTNVFLFTLARVPVGVFK-HTLSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDGgfYVTAFMCCS 196
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAgALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG--WRAAFLILA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  197 VFLLNAGLVWLLPwretslnipdsgwsldqkhatvtiksestlqgaaTTPEARRSGRNLRPPWVEVMSTLKDmknlIFSA 276
Cdd:pfam07690 159 ILSLLAAVLLLLP----------------------------------RPPPESKRPKPAEEARLSLIVAWKA----LLRD 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  277 LWDVFLVRLLMGVAVMLYYSNFVLALEERFGVRPKTTGYLISYTSALGTLAGFAVGPILRLYKHNSHMVLLHSSALTCLL 356
Cdd:pfam07690 201 PVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAAL 280

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157817386  357 L-LLYSTTNSMAMVVLSSTLLSFSTTIGRTCITDLQLSVGGAQASGTVIGVGQSVTAVGRILAP 419
Cdd:pfam07690 281 GlLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 39-450 4.87e-16

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 79.54  E-value: 4.87e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  39 LYLVGFLDLFGVSMTVPLLNLHVRSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSALGYLLLGM 118
Cdd:cd17474    4 VFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 119 STNVFLFTLARVPVGV-FKHTLSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDggfYVTAFMCCSV 197
Cdd:cd17474   84 SDSFALLLAGRALQGIgAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAIS---WRYPFFLLAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 198 FLLNAGLVWLLPwretslnipdsgwsLDQKHATVTIKSESTLqgaattpeaRRSGRNLRPPWVEVMSTLKDMKNLIFSAL 277
Cdd:cd17474  161 LIPVAFLAILFL--------------LPEPKEKAKSSSATKL---------RDLKKALRGRGLLTFLVSAFLYFFLYFAF 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 278 wdvflvrllmgvavmLYYSNFVlaLEERFGVRPKTTGYLISYTSALGTLAGFAVGPILRLyKHNSHMVLLHSSALTCLLL 357
Cdd:cd17474  218 ---------------LTYLPFL--LELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKK-RFGARRILVIGLLLYALSL 279

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 358 LLYSTTNSMAMVVLSSTLLSFSTTIGRTCITDLQLSVGGAQASGTVIGVGQSVTAVGRILAPLLSGLAQEISPCGPPSLG 437
Cdd:cd17474  280 LLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLV 359

                        410
                 ....*....|...
gi 157817386 438 AALALVAILIMTL 450
Cdd:cd17474  360 GAAIALAAAVLLA 372
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 72-200 1.89e-14

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 74.62  E-value: 1.89e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  72 GIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSALGYLLLGMSTNVFLFTLARVPVGVFKHTLSISRALLSDLVT 151
Cdd:cd17389   67 GLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVTS 146

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 157817386 152 EKERPLVLGQFNTASGVGFILGPVIGGYLTELDGGFYVTAFMCCSVFLL 200
Cdd:cd17389  147 PKKRSKGMALIGVAFSLGFIIGPMIGAYFASFTRSLGEVFFSMPALFAL 195
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 1-208 5.59e-14

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 72.99  E-value: 5.59e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386   1 MALGVRGRGASGQDLTSETPVTATASSSAVSSRRFLLWLYLVGFLDLFGVSMTVPLLNLHVRSL-GVSPVVAGIVGSSYG 79
Cdd:cd17325  166 LALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGAQG 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  80 ILQLFSSTFVGCWSDVVGRRCSLLVCILLSALGYLLLGMSTNVFLFTLARVPVGVFKHTLSIS-RALLSDLVTEKERPLV 158
Cdd:cd17325  246 LASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPAtLALLADIVPPEGRGTA 325

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 157817386 159 LGQFNTASGVGFILGPVIGGYLTELDGGFyvTAFMCCSVFLLNAGLVWLL 208
Cdd:cd17325  326 MGLFNTAFSLGMVLGPLLGGFLYDAFGFA--TPFLAAAALLLLAAVLFLL 373
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 39-451 1.36e-13

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 72.07  E-value: 1.36e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  39 LYLVGFLDLFGVSMTVPLLNLHVRSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSALGYLLLGM 118
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 119 STNVFLFTLARVPVGVFKHTLSISR-ALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDGGFYVTAFMCCSV 197
Cdd:cd06174   81 APSFWLLLLGRFLLGLGSGLIDPAVlALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 198 FLLNAGLVWLLPWRETSlnipdsgwsldqkhatvtiksestlqgaattpeARRSGRNLRPPWVEVMSTLKDMKNliFSAL 277
Cdd:cd06174  161 LALLAAILLLLVVPDPP---------------------------------ESARAKNEEASSKSVLKLLKRVLK--NPGL 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 278 WDVFLVRLLMGVAVMLYYSNFVLALEERFGVRPKTTGYLISYTSALGTLAGFAVGPILRLYKHNSHMVLLHSSALTCLLL 357
Cdd:cd06174  206 WLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLA 285

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 358 LLYSTTNSMAMVVLSStLLSFSTTIGRTCITDLQLSVGGAQASGTVIGVGQSVTAVGRILAPLLSGLAQEISPCGPPSLG 437
Cdd:cd06174  286 LLLLAPSLLLLLLLLL-LLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFL 364

                        410
                 ....*....|....
gi 157817386 438 AALALVAILIMTLY 451
Cdd:cd06174  365 VLAVLLLLAAILLL 378
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
35-454 2.11e-11

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 65.28  E-value: 2.11e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  35 FLLWL-YLVGFLDLFGVSMTVPLLnlhVRSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSALGY 113
Cdd:COG2271   13 ALLFLaYFLNYLDRSNLSVAAPPL---QADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 114 LLLGMSTNVFLFTLARVPVGVFKHTLSISR-ALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDG---GFYV 189
Cdd:COG2271   90 LLFGFATSFWQLLLLRFLLGLGEAGFFPAAlKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGwraAFLI 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 190 TAFmccsvfllnAGLVWLLPwretslnipdsgwsldqkhatvtiksestlqgaattpearrsgrnlrppwvevmstlkdm 269
Cdd:COG2271  170 LGL---------PGLLLALL------------------------------------------------------------ 180

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 270 knlifsALWDVFLVRLLMGVAVMLYYSNFVLALEERFGVRPKTTGYLISYTSALGTLAGFAVGPILRLYKHNSHMVLLHS 349
Cdd:COG2271  181 ------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIG 254

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 350 SALTCLLLLLYSTTNSMAMVVLSSTLLSFSTTIGRTCITDLQLSVGGAQASGTVIGVGQSVTAVGRILAPLLSGLAQEIS 429
Cdd:COG2271  255 LLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT 334

                        410       420
                 ....*....|....*....|....*.
gi 157817386 430 PCGPP-SLGAALALVAILIMTLYRPP 454
Cdd:COG2271  335 GYQAAfLLLAALALLAALLALLLLRE 360
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 36-334 1.81e-10

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 62.27  E-value: 1.81e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  36 LLWLYLVGFLDLFGVSMTVPLLNLHVRSLGVSPVVA----GIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSAL 111
Cdd:cd17388    1 LIFILVTVLLDAMGIGLIMPVLPTLLREFVGDSADAathyGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 112 GYLLLGMSTNVFLFTLARVPVGVFKHTLSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELD--GGFYV 189
Cdd:cd17388   81 DYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISprAPFLV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 190 TAFMCCSVFLLnaGLVWLlpwretslnipdsgwsldqkhatvtiksestlqgaattPEARRSGRNLRPPWVEV-----MS 264
Cdd:cd17388  161 AAGLNGLNFLL--GLFVL--------------------------------------PESLPPERRRAFRWRRAnpfgsLR 200

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157817386 265 TLKDMKNLifSALWDVFLVRLLMGVAVMlyySNFVLALEERFGVRPKTTGYLISYTSALGTLA-GFAVGPI 334
Cdd:cd17388  201 WLTGFPGL--LGLLAVFFLIQLIGQVPA---TTWVLFTEDRFDWSPTMVGLSLAVFGLLHALFqAFVTGPI 266
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 33-185 3.65e-10

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 60.98  E-value: 3.65e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  33 RRFLLWLYLVGFLDLFGVSMTVPLLNLHVRSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSALG 112
Cdd:COG0477   13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157817386 113 YLLLGMSTNVFLFTLARVPVGVFKHTLS-ISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDG 185
Cdd:COG0477   93 SLLCGLAPSPELLIAARALQGIGAGGLMpGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALG 166
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 41-200 4.09e-10

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 61.44  E-value: 4.09e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  41 LVGFLDLFGVSMTVPLLNLHVRSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSALGYLLLGMST 120
Cdd:cd17323    6 FLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAP 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 121 NVFLFTLARVPVGVFKHT-LSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDG---GFYVTAFMCCS 196
Cdd:cd17323   86 NIAMLIILRFLQGFFGSSpLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGwrwIFWFLAIISGF 165


                 ....
gi 157817386 197 VFLL 200
Cdd:cd17323  166 CLIL 169
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 33-207 1.25e-09

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 59.86  E-value: 1.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  33 RRFLLWLYLVGFLDLFGVSMtvPLLNLHVRSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRR----CSLLVCILL 108
Cdd:cd17370  200 KAFWLYLLAVALFALGNFSF--AFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKklliLGYLSLALA 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 109 SALGYLLLGMSTNVFLFTLARVPVGVfkhTLSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLteLDGGFY 188
Cdd:cd17370  278 YLGFALGSSLWLLLLGFILWGLYMGA---QESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYL--WDLISP 352

                        170
                 ....*....|....*....
gi 157817386 189 VTAFMCCSVFLLNAGLVWL 207
Cdd:cd17370  353 SAAFLFSAVLALIALLLLL 371
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 44-200 1.42e-09

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 59.59  E-value: 1.42e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  44 FLDLFGVSMTVPLLNLHVRSLGVSPVV-----AGIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSALGYLLLGM 118
Cdd:cd17391    6 FFTGIGFSLIAPFLPLYIEQLGVTSGGlvelwSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAF 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 119 STNVFLFTLARVPVGVFKHTLSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDG---GFYVTAFMCC 195
Cdd:cd17391   86 VTNVWQLLILRLLQGVFSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGirnVFFITGGLLF 165


                 ....*
gi 157817386 196 SVFLL 200
Cdd:cd17391  166 LAFLL 170
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 36-209 7.98e-09

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 57.24  E-value: 7.98e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  36 LLWLYLVGFLDLFGVSMTVPLLNLHV-RSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSALGYL 114
Cdd:cd17329    1 LWVLLIGSFLNRLGFFMVWPFMAIYLhQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 115 LLGMSTNVFLFTLARVPVGVFKhTLSI--SRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDGGFYVTAF 192
Cdd:cd17329   81 LLGFAHSPWLFAIALVLTGFGG-GLFEpaSEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAA 159

                        170
                 ....*....|....*..
gi 157817386 193 MCCSVFLLnAGLVWLLP 209
Cdd:cd17329  160 AVLFLLAA-LVLLFLLP 175
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 39-209 9.52e-09

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 56.83  E-value: 9.52e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  39 LYLVGFLDLFGVSMTVPLLNLHVRSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSALGYLLLGM 118
Cdd:cd17489    1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 119 STNVFLFTLARVPVGV-FKHTLSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELdGGFYVTAFMCCSV 197
Cdd:cd17489   81 ATSVALLLVLRLIHGIgWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQH-LGFAVLFIVAAVL 159

                        170
                 ....*....|..
gi 157817386 198 FLLNAGLVWLLP 209
Cdd:cd17489  160 ALLALLLVFLVK 171
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 39-212 8.06e-08

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 54.10  E-value: 8.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  39 LYLVGFLDLFGVSMTVPLLNLHVRSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSALGYLLLGM 118
Cdd:cd17477    1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 119 STNVFLFTLARVPVGVFKHTLSI-SRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDggfyVTAFMCCSV 197
Cdd:cd17477   81 TDSPWVWFLLRFVMGIGLAGLFVvSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAG----ALPFLIAAV 156

                        170
                 ....*....|....*
gi 157817386 198 FLLNAGLVWLLPWRE 212
Cdd:cd17477  157 LLLLALVPLLLTRRA 171
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 36-209 1.20e-07

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 53.71  E-value: 1.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  36 LLWLYLVGFLDLFGVSMTVPLLNLHVRSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSALGYLL 115
Cdd:cd17324    1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 116 LGMSTNVFLFTLARVPVGVFkHTL--SISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDGGFYVTAFM 193
Cdd:cd17324   81 AALAPSFALLLLARALAGLA-HGGfwAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAI 159

                        170
                 ....*....|....*.
gi 157817386 194 CCSVFLLNAGLVWLLP 209
Cdd:cd17324  160 AVLALLAALLLWRLLP 175
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
33-200 4.51e-07

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 51.84  E-value: 4.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  33 RRFLLWLYLVGFLDLFGVSMTVPLLNLHVRSLGVSPVVA-----GIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCIL 107
Cdd:PRK09874  13 KRNLTVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTGHSAlnmwsGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSAL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 108 LSALGYLLLGMSTNVFLFTLARVPVGVFKHTLSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTE---LD 184
Cdd:PRK09874  93 GMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADsygLR 172

                        170
                 ....*....|....*.
gi 157817386 185 GGFYVTAFMCCSVFLL 200
Cdd:PRK09874 173 PVFFITASVLFLCFLV 188
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 39-200 7.77e-07

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 51.47  E-value: 7.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  39 LYLVGFLDLFGVSMTVPLLNLHVRSLGVSPVVAGIVgSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSALGYLLLGM 118
Cdd:cd06179    3 LCLAYFAQLFGVTLPAAVLPFIVADLGPSSNSTWIS-TAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 119 STNVFLFTLARVPVGVFKHTLSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDGG-----FYVTAFM 193
Cdd:cd06179   82 AKSVNMLIGGQALIGIGAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAAgwrwiFYINAIF 161


                 ....*..
gi 157817386 194 CCSVFLL 200
Cdd:cd06179  162 NALALIL 168
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 62-191 1.78e-06

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 49.93  E-value: 1.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  62 RSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSALGYLLLGMSTNVFLFTLARVPVGVFKHTLS- 140
Cdd:cd17328   27 SDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSp 106

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 157817386 141 ISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDGG----FYVTA 191
Cdd:cd17328  107 IAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGwrwaFRVTG 161
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 39-223 1.83e-06

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 49.91  E-value: 1.83e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  39 LYLVGFLDLFGVSMTVPLLNLHVRSL-GVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSALGYLLLG 117
Cdd:cd17472    1 LSLIFSLRMLGMFLVLPVLSVYAKSLpGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 118 MSTNVFLFTLARVPVGVFKHTLSISrALLSDLVTEKERPLVLG----QFNTASGVGFILGPVIGGYLTeLDGGFYVTAFM 193
Cdd:cd17472   81 YATSIYGLILGRALQGSGAISSVVM-ALLADLTREENRTKAMAligaSIGIAFAISMVLGPLLAAHLG-VSGLFLITAIL 158

                        170       180       190
                 ....*....|....*....|....*....|
gi 157817386 194 CCSVFLLnagLVWLLPWRETSLNIPDSGWS 223
Cdd:cd17472  159 SLVSLLI---LLFFVPDPPKIVQISEKEKK 185
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 74-182 2.55e-06

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 49.10  E-value: 2.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  74 VGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSALGYLLLGMSTNVFLFTLARVPVGVFKHTL-SISRALLSDLVTE 152
Cdd:cd17502   35 VGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLmSLAFIIIADLVPP 114

                         90       100       110
                 ....*....|....*....|....*....|
gi 157817386 153 KERPLVLGQFNTASGVGFILGPVIGGYLTE 182
Cdd:cd17502  115 RERGKYQGYIGAVFGIASVAGPLIGGAFTD 144
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
61-213 3.33e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 49.10  E-value: 3.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  61 VRSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRR--CSLLVCILLSALGYLLLGMSTNVFLFTLARVPVGVFKHT 138
Cdd:COG2271  208 VEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGG 287

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 157817386 139 LSISR-ALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLteLDGGFYVTAFMCCSVFLLNAGLVWLLPWRET 213
Cdd:COG2271  288 AFGLLwALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYL--LDATGYQAAFLLLAALALLAALLALLLLRET 361
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 39-185 4.09e-06

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 48.76  E-value: 4.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  39 LYLVGFLDLFGVSMTVPLLNLHVRSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVC-ILLSALGYLLLG 117
Cdd:cd17490    1 FLIIVFLFWFSQYVYVPFLSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIgLLFTVLASLIMI 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157817386 118 MSTNVFLFTLARVPVGVFKHTLSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDG 185
Cdd:cd17490   81 LFPSPWGLLIARFLSGIAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFG 148
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 36-209 5.79e-06

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 48.34  E-value: 5.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  36 LLWLYLVGFLDLFGVSMTVPLLNLHVRSLGVSPVVAGIVGSSY----GILQLFsstfVGCWSDVVGRRCSLLVCILLSAL 111
Cdd:cd17320    1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYllgfALGQLL----YGPLSDRFGRRPVLLAGLLLFIL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 112 GYLLLGMSTNVFLFTLARVPVGVFKHTLS-ISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDGGFYVT 190
Cdd:cd17320   77 ASLLCALASSIEQLLIARFLQGLGAAAGSvVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIF 156

                        170
                 ....*....|....*....
gi 157817386 191 AFMCCSVFLLNAGLVWLLP 209
Cdd:cd17320  157 VFLALLGLLLLLLVLLFLP 175
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 34-209 6.87e-06

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 48.15  E-value: 6.87e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386   34 RFLLWLYLVGFLDLFGVSMTVPLLNLHVRSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSALGY 113
Cdd:TIGR00710   5 AFALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  114 LLLGMSTNVFLFTLARVPVGVFKHT-LSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDGGFYVTAF 192
Cdd:TIGR00710  85 LGLALSNNIETLLVLRFVQAFGASAgSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAF 164

                         170
                  ....*....|....*..
gi 157817386  193 MCCSVFLLNAGLVWLLP 209
Cdd:TIGR00710 165 LSLAGILLSALIFFILP 181
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 39-211 8.08e-06

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 47.96  E-value: 8.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  39 LYLVGFLDLFGVSMTVPLLNLHVRSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSALGYLLLGM 118
Cdd:cd17504    1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 119 STNVFLFTLARVPVGVFKHTLSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTElDGGFYVTAFMCCSVF 198
Cdd:cd17504   81 APNLPVLIAGRALQGIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQ-HLGWRWIFWTAAPVA 159

                        170
                 ....*....|...
gi 157817386 199 LLNAGLVWLLPWR 211
Cdd:cd17504  160 VLLAALVPLIDLR 172
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 40-208 8.71e-06

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 47.59  E-value: 8.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  40 YLVGFLDLFGVSMTVPLLNLHVRSLGVSpvVAGIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSALGYLLLGMS 119
Cdd:cd17489  200 ALILFLASIAYGAISTFLPLYAAERGIS--NAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFA 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 120 TNVFLFTLARVPVGV-FKHTLSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDGgfYVTAFMCCSVF 198
Cdd:cd17489  278 GSPWMLLLAAVLYGLgFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFG--YRAMFLLAAVV 355

                        170
                 ....*....|
gi 157817386 199 LLNAGLVWLL 208
Cdd:cd17489  356 VLLALVLYIF 365
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
40-452 2.10e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 46.41  E-value: 2.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  40 YLVGFLDLFGVSMTVPLLNlhvRSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSALGYLLLGMS 119
Cdd:COG2223   14 FFLAFGVWYLWSVLAPPLA---EEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALA 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 120 TNVFLFTLARVPVGV-----FkhtlSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDGgfYVTAFMC 194
Cdd:COG2223   91 VSYWLLLLLGLLLGIggggsF----AVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFG--WRNAFLI 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 195 CSVFLLNAGLVWLLPWRETSLNIPDSGwsldqkhatvtiksestlqgaattpearrsgrnlRPPWVEVMSTLKDMKNLIF 274
Cdd:COG2223  165 LGILLLVVAVLAWLFLRDPPAGAAAAA----------------------------------KASLRDQLEALRDPRFWLL 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 275 SALWdvflvrLLMGVAVMLYYSNFVLALEERFGVRPKTTGYLISYTSALGTLAGFAVGPIL-RLYKHNSHMVLLhsSALT 353
Cdd:COG2223  211 SLLY------FGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSdRIGGRRVLLIVF--ALMA 282

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 354 CLLLLLYSTTNSMAMVVLSSTLLSFSTTIGRTCITDLQLSVGGAQASGTVIGVGQSVTAVGRILAPLLSGLAQEISpcGP 433
Cdd:COG2223  283 LGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAT--GS 360

                        410       420
                 ....*....|....*....|...
gi 157817386 434 PSLG----AALALVAILIMTLYR 452
Cdd:COG2223  361 YTAAflvfAVLALVALVLTLLLY 383
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
35-212 2.36e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 46.41  E-value: 2.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  35 FLLWLYLVGFLDLFGVSMTVPLLnlHVRSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVC-ILLSALGY 113
Cdd:COG2223  209 LLSLLYFGTFGSFIGFSSWLPPY--LVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVfALMALGLL 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 114 LLLGMSTNVFLFTLARVPVGVFkhtLSISRALLSDLVTE----KERPLVLGQFNTASGVGFILGPVIGGYLTELDGGfYV 189
Cdd:COG2223  287 LLALALGSLWLFLVLFLLLGLA---LGGGNGAVFALVPDifptKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGS-YT 362

                        170       180
                 ....*....|....*....|....
gi 157817386 190 TAFMCCSVF-LLNAGLVWLLPWRE 212
Cdd:COG2223  363 AAFLVFAVLaLVALVLTLLLYRRP 386
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 41-185 4.93e-05

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 45.24  E-value: 4.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  41 LVGFLDLFGVSMTVPLLNLHVRSLGVSPVVAGIVGSSYgilQLFSSTFV---GCWSDVVGRRCSLLVCILLSALGYLLLG 117
Cdd:cd17321    3 LAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAY---LLAFAALLllaGRLGDRFGRKRVFLIGLALFGLASLLCA 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157817386 118 MSTNVFLFTLARVPVGVFKHTL-SISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDG 185
Cdd:cd17321   80 LAPSLAFLIAARALQGIGAAAImPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFG 148
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 64-452 6.41e-05

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 44.87  E-value: 6.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  64 LGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSALGYLLLGMSTNVFLFTLARVPVGVFKH-TLSIS 142
Cdd:cd17473   30 VPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAgIMTLA 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 143 RALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELD--GGFYVTAFMccsvfLLNAGLVWLLPWREtslnipds 220
Cdd:cd17473  110 TALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGwrAPFLVYLLA-----LPVLILVLLFLPEP-------- 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 221 gwsldqkhatvtiksestlQGAATTPEARRSGRNLRPPWVevmstlkdmknlifsalwDVFLVRLLMGVAVMLYYS---N 297
Cdd:cd17473  177 -------------------ARKSKSAASPGAATAAALPWK------------------RVLPIYFLAFLAMLLFYVipiQ 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 298 FVLALEERFGVRPKTTGYLISYTSALGTLAGFAVGPILRLYKHNSHMVLlhSSALTCLLLLLYSTTNSMAMVVLSSTLLS 377
Cdd:cd17473  220 LPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAI--GFALMALGFLLLALASGLWVVLLGAILAG 297

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157817386 378 FSTTIGRTCITDLQLSVGGAQASGTVIGVGQSVTAVGRILAPLLSGLAQEI--SPCGPPSLGAALALVAILIMTLYR 452
Cdd:cd17473  298 LGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLtgGLSGAFLILGVLALVLAIVLLLLR 374
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 35-208 1.13e-04

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 44.10  E-value: 1.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  35 FLLWLYLVGFLDLFGVSMTVPLLNlhvRSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSALGYL 114
Cdd:cd17319    7 LLFLAYVINYLDRVNISVAAPTIM---KDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 115 LLGMSTNVFLFTLARVPVGVFKHTL-SISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDGGFYvtAFM 193
Cdd:cd17319   84 LTGFATSLTSLYVLRFLLGVAEAGFfPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRW--AFI 161

                        170
                 ....*....|....*
gi 157817386 194 CCSVFLLNAGLVWLL 208
Cdd:cd17319  162 IEGLLGLLLAVLWWF 176
MFS_1 pfam07690
Major Facilitator Superfamily;
1-174 1.65e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 43.56  E-value: 1.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386    1 MALGVRGRGASGQDLTSETPVTATASSSAVSSRRFLLWLYLVGFLDLFGVSMTVPLLNLHVRSLGVSPVVAGIVGSSYGI 80
Cdd:pfam07690 167 LLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGL 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386   81 LQLFSSTFVGCWSDVVGRRCSLLVCILLSALGYLL---LGMSTNVFLFTLARVPVGV-FKHTLSISRALLSDLVTEKERP 156
Cdd:pfam07690 247 LGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGlllLSLTLSSLWLLLALLLLGFgFGLVFPALNALVSDLAPKEERG 326

                         170
                  ....*....|....*...
gi 157817386  157 LVLGQFNTASGVGFILGP 174
Cdd:pfam07690 327 TASGLYNTAGSLGGALGP 344
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 36-450 1.95e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 43.37  E-value: 1.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  36 LLWLYLVGFLDLFGVSMTVPLLNLHVRSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRR------------CSLL 103
Cdd:cd06173    1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRrlliladllralLAAV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 104 VCILLSALGYLLLGMSTNVFLFTLARVPVGVfkhtlsISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTEL 183
Cdd:cd06173   81 LALLALLGSLSLWLLLVLAFLLGIASAFFGP------ARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVAL 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 184 DGGFYVTAFMCCSvFLLNAGLVWLLPWRETSLNIPDSGWSLDQKHatvtiksestlqgaattpEARRSGRNLRPpwvevm 263
Cdd:cd06173  155 LGPGGAFAINALS-FLLSALLLLFIRRPPPAAPGESSSLLLRDLR------------------EGLRYLRRSPL------ 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 264 stlkdmknlifsaLWDVFLVRLLMGVAVMLYYSNFVLALEERFGVRPKTTGYLISyTSALGTLAGFAVGPILRLYKHNSH 343
Cdd:cd06173  210 -------------LRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLA-AFGVGALLGALLLGRLSKRRRRGR 275

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 344 MVLLhSSALTCLLLLLYSTTNSMAMVVLSSTLLSFSTTIGRTCITDLQLSVGGAQASGTVIGVGQSVTAVGRILAPLLSG 423
Cdd:cd06173  276 LLLI-GALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAG 354

                        410       420
                 ....*....|....*....|....*...
gi 157817386 424 -LAQEISPCGPPSLGAALALVAILIMTL 450
Cdd:cd06173  355 lLADALGLSAVFLLAGALLLLAALLLLL 382
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
37-452 6.26e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 42.20  E-value: 6.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  37 LWLYLVGFL--DLFGVSMTVPLLNLHVRSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVV----GRR-------CSLL 103
Cdd:COG2211   12 KLAYGLGDLglNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTrtrwGRRrpwiligAIPL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 104 VCILLSALGYLLLGMSTNVFLFTLARVPVGVFKHTLSIS-RALLSDLVTE-KERPLVLGQFNTASGVGFILGPVIGGYLT 181
Cdd:COG2211   92 ALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPySALGAELTPDyEERTRLSSWRFAFAGLGGLLASVLPPPLV 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 182 ELDGGF----YVTAFMCCSVFLLnagLVWLLPWRetslnipdsgwsldqkhatvtiksestlqgaaTTPEARRSGRNLRP 257
Cdd:COG2211  172 AAFGGDaalgYRLTALIFAVLGL---LAFLLTFF--------------------------------GTKERPVPEEEKVS 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 258 PWVEVMSTLKDmknlifSALWDVFLVRLLMGVAVMLYYSNFVLALEERFGVRPKTTGYLISYTSALGTLAGFAVGPILRL 337
Cdd:COG2211  217 LKESLKALLKN------RPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKR 290

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 338 Y-KHNSHMVLLhSSALTCLLLLLYSTTNSMAMVVLSSTLLSFSTTIGRTC-------ITDLQLSVGGAQASGTVIGVGQS 409
Cdd:COG2211  291 FgKKKAFIIGL-LLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLpwamladVVDYDEWKTGRRREGLYFGIFTF 369

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 157817386 410 VTAVGRILAPLLSGLAQEIS-----PCGPPS-----------LGAALALVAILIMTLYR 452
Cdd:COG2211  370 AIKLGQALAGALAGLLLALFgyvagAAQSPSaltgirllfflLPAVLLLLAALLLLFYP 428
MFS_MFSD14 cd17387
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ...
 41-185 7.19e-04

Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340945 [Multi-domain]  Cd Length: 410  Bit Score: 41.64  E-value: 7.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  41 LVGFLDLFGVSM-TVPLLNLHVRSLGVSP-VVAGIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSALGYLLLGM 118
Cdd:cd17387    6 VVIFLEFFAWGLlTTPMITVLHETFPQHTfLMNGLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMRI 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157817386 119 STNVFlFTLARVPvGVFKHTLSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDG 185
Cdd:cd17387   86 SPWWY-FAMISVS-GIFSVTFSVIFAYVADITTEEERSTAYGLVSATFAASLVTSPALGAYLSESYG 150
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 72-184 8.14e-04

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 41.43  E-value: 8.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  72 GIVGSSYGILQLFSSTFVGCWSDVVGRR-----CSLLVCILLSAL-GYLLLGMSTNVFLFTLARVPVGVFKHTLSISRAL 145
Cdd:cd17326   39 GWVVAAYSLGQLVFSPVFGYWSNKTSSVkepliVSILIAIVGNILyALAEYFPSNRKYVMLVARFLIGVGAGNVAVLRAY 118

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 157817386 146 LSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELD 184
Cdd:cd17326  119 VAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTPIG 157
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 36-208 8.88e-04

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 41.40  E-value: 8.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  36 LLWLYLVGFLDLFGVSMTVPLLNlhVRSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDV-VGRRCSLLVCILLSALGYL 114
Cdd:cd17474  203 FLVSAFLYFFLYFAFLTYLPFLL--ELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLL 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 115 LLGMSTNVFLFTLARVPVGVFkhtLSISRALLSDLVTE----KERPLVLGQFNTASGVGFILGPVIGGYLTELdGGFYVT 190
Cdd:cd17474  281 LLGFVPSLALLLIAIVLFGLG---LGLNLPLLTTLVTElapeEERGTASSLYNFVRFLGQAVGPLLFGLLLEI-FGLSAP 356

                        170
                 ....*....|....*...
gi 157817386 191 AFMCCSVFLLNAGLVWLL 208
Cdd:cd17474  357 FLVGAAIALAAAVLLALL 374
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 39-323 1.02e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 41.38  E-value: 1.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  39 LYLVGFLDLFGVSMTVPLLNLH-VRSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDV-VGRRCSLLVCILLSALGYLLL 116
Cdd:cd17471    1 LLLATLLTGLAGAFVLPYLSLFlTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRgGDRKPLILLALLAGALGYLLF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 117 GMSTNVFLFTLARVPVG-----VFKHTLSISRALLsDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLteLDGGFYVTA 191
Cdd:cd17471   81 AFLRNYWVLLLVGVVLLslgaaAFPQLFALAREYA-DRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLL--LDVLGFTGL 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 192 FMCCSV-FLLNAGLVWLLPwretslnipdsgwsldqkhatvtIKSESTLQGAATTPEARRSGRNLRppwvevmstlkdmk 270
Cdd:cd17471  158 FLLAALlYLVVALLVLFLL-----------------------PSVKPPAQKATPASSLVKAPVNRR-------------- 200

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 157817386 271 nlifsaLWDVFLVRLLMGVAVMLYYSNFVLALEERFGVRPKTTGYLISYTSAL 323
Cdd:cd17471  201 ------LLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLLFGLAAAL 247
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 35-209 1.03e-03

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 41.03  E-value: 1.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  35 FLLWLYLV--GFlDLFGVSMTVPLLnlhVRSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSALG 112
Cdd:cd17365    2 ALCFLIIVldGF-DLAVMGFVAPAL---AQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLF 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 113 YLLLGMSTNVFLFTLARVPVGV-FKHTLSISRALLSDLVTEKERplvlGQFNTASGVGFILGPVIGGYLteldGGFYVTA 191
Cdd:cd17365   78 TLLTAFAQSVLQLALLRFLTGLgLGAAMPNAITLVSEYAPARRR----SLAVTLMFCGYPLGAALGGFL----AAALIPA 149

                        170
                 ....*....|....*...
gi 157817386 192 FMCCSVFLLNAGLVWLLP 209
Cdd:cd17365  150 FGWRSVFLLGGVPPLILL 167
MFS_YjiJ cd06180
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...
 33-209 1.36e-03

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340869 [Multi-domain]  Cd Length: 371  Bit Score: 40.75  E-value: 1.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  33 RRFLLWLYLVGFLdLFGVSMTVP--LLNLHVRSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSA 110
Cdd:cd06180  194 LNRPLWRLALAYG-LFGFGYIITatFLPLIARETGAGSLLAGLLWSLFGLAAVPSCFLWGALSDRWGTRRALAANLLVQA 272

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 111 LGYLLLGMSTNVFLFTLARVPVGV-FKHTLSISRALLSDLvTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDGGFYv 189
Cdd:cd06180  273 VGVLLPLLSPGPAGLVLSAVLFGGtFMAITALVMALAREL-APPAAPRALALMTASFGVGQILGPLLAGWLADATGGFA- 350

                        170       180
                 ....*....|....*....|
gi 157817386 190 TAFMCCSVFLLNAGLVWLLP 209
Cdd:cd06180  351 PALILAAAALVVAALLALLV 370
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 33-208 1.64e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 40.68  E-value: 1.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  33 RRFLLWLYLVGFLDLFGVSMTVPLLNLHVRSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSALG 112
Cdd:cd06173  208 PLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLA 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 113 YLLLGMSTNVFLFTLARVPVGVFKHTLSISR-ALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDGgfYVTA 191
Cdd:cd06173  288 LLVLGLSPSLWLLLAALFLLGLAGGLFNVPLnTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALG--LSAV 365

                        170
                 ....*....|....*..
gi 157817386 192 FMCCSVFLLNAGLVWLL 208
Cdd:cd06173  366 FLLAGALLLLAALLLLL 382
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 44-231 2.67e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 39.85  E-value: 2.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  44 FLDLFGVSMTVPLLNLHVRSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSALGYLLLGMSTN-- 121
Cdd:cd17478    6 FLNDFYQGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNyw 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 122 --VFLFTLARVPVGVFkHTLSisrALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDGGFYVTAFMccsVFL 199
Cdd:cd17478   86 llLLLVALAGIGSAAF-HPEG---ARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILL---IIP 158

                        170       180       190
                 ....*....|....*....|....*....|..
gi 157817386 200 LNAGLVWLLPWRETSLNIPDSGWSLDQKHATV 231
Cdd:cd17478  159 GLAVALLLLRLRPLKKPEAKKAAAKSSARSTL 190
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 38-346 2.95e-03

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 39.87  E-value: 2.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  38 WLYLVGFLDLFGVSMTVPLLNLHVRSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVG-RRCSLLVCILLSALGYLLL 116
Cdd:cd17335    1 RLKLFYFFFFAALGSLLPFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVLFFLSL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 117 GMSTNVF-LFTLARVPVGVFKH-TLSISRALLSDLVteKERPLVLGQFNTASGVGFILGPVIGGYLTELDGGF--YVTAF 192
Cdd:cd17335   81 FFVAQIFwLLLLLVILGAFFSApVVPLVDSITLQYL--GEERERYGKQRLWGSIGFGIAALLVGILIDRSSTYknYTIAF 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 193 MCCSVF-LLNAGLVWLLPwretslnipdsgwsLDQKHATVTIksestlqgaattpearrsgrnlrpPWVEVMSTLKDMKN 271
Cdd:cd17335  159 YVFAVLmLLALLLALKFP--------------FRPKHPEPNE------------------------NTGGLLALLRNPRV 200

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157817386 272 LIFsalwdvFLVRLLMGVAVMLYYSNFVLALEERFGvrpktTGYLISYTSALGTLAG----FAVGPILRLYKHNSHMVL 346
Cdd:cd17335  201 LAF------LLVAFLMGFGHGLIYSFLFWHLQDLGG-----SKTLIGLLWTVGVVSEipffFFSSRLIQRFGHVGLLYL 268
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 39-200 6.76e-03

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 38.76  E-value: 6.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  39 LYLVGFLdLFGVSMTVPLLN----LHVRSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVV----GRR------CSLLV 104
Cdd:cd17313    1 LFLLGFG-FFGIEFGWALENsyvpPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCnsriGRRrpfilvGAPLA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 105 CILLS--------ALGYLLLGMSTNVFLFTLARVPVGVFKHTL-SISRALLSDLVTEKERPLVLGQFNTASGVGFILGPV 175
Cdd:cd17313   80 ALGLIlipnaadiGLALGDGPRTWALVLFVLGIVLLDFAMNVCqGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLGYL 159

                        170       180       190
                 ....*....|....*....|....*....|.
gi 157817386 176 IGGYLTE------LDGGFYVTAFMCCSVFLL 200
Cdd:cd17313  160 LGAILWDhnwfgfALGGNLKVPFYIGAIILL 190
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 79-202 7.48e-03

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 38.41  E-value: 7.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  79 GILQLFSSTFVGCWSDVVGRR----CSLLVCILLSALGYLLLGMST--NVFLFTLARVPVGVFKH---TLSISRALLSDL 149
Cdd:cd17386   40 SIPPLFSSLFLGSWSDRYGRKppllMSLVGLLLSSLILVLIVYFTTvpSVWWFYLSAIPLALFGGftaFLSASFAYISDI 119

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 157817386 150 VTEKERPLVLGQFNTASGVGFILGPVIGGYLTElDGGFYVTaFMCCSVFLLNA 202
Cdd:cd17386  120 SSEKKRTYRMAILEVALGLGGFLGSLLSGHLFK-ALGYAWS-FSISAALLLIA 170
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 35-188 8.12e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 38.35  E-value: 8.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  35 FLLWL-YLVGFLDLFGVSMTVPLLnLHVRSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCILLSALGY 113
Cdd:cd17316    2 LLAGLgWFFDAYDFFLIGFVAPVL-AAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 157817386 114 LLLGMSTNVFLFTLARVPVGVF-KHTLSISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTELDGGFY 188
Cdd:cd17316   81 LLIGLLPTPILLLVLRFLQGIGiGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDW 156
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 56-200 8.47e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 38.31  E-value: 8.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  56 LLNLHVRSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRR-----CSLLVCILLSALGYLLLGMSTNVFLFTLArv 130
Cdd:cd17477  210 LLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRrvllgCALLGALAALLLPLVPGLPLALLVLLFLW-- 287

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157817386 131 pvGVFKHTL-SISRALLSDLVTEKERPLVLGQFNTASGVGFILGPVIGGYLTEL--DGGFYVTAFMCCSVFLL 200
Cdd:cd17477  288 --GGAAGPLyTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAfgPHGLFLFLAAVALLFLL 358
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
33-450 9.49e-03

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 38.32  E-value: 9.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386  33 RRFLLWLYLVGFLdLFGVSMTV------PLLNLHVRSLGVSPVVAGIVGSSYGILQLFSSTFVGCWSDVVGRRCSLLVCI 106
Cdd:COG2807   12 RRAGRWLLLLAIV-LVALNLRPaitsvgPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLAL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 107 LLSALGYLLLGMSTNVFLFTLARVPVGVfkhTLSISRALLSDLVTE---KERPLVLGQFNTASGVGFILGPVIGGYLTEL 183
Cdd:COG2807   91 LLLAAGLLLRSLAPSVALLLAGTALIGA---GIAVGNVLLPGLIKRwfpDRVGLMTGLYTAAMGLGAALAAGLTVPLAAA 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 184 DGgfYVTAFMCCSVFLLNAGLVWLLPWRETSlnipdsgwsldqkhatvtiksestlQGAATTPEARRSGRNLRPPwvevm 263
Cdd:COG2807  168 LG--WRGALAVWALLALLALLLWLPLLRRRP-------------------------AAAAAAPAAASLRSLWRSP----- 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 264 stlkdmknlifsALWdvfLVRLLMGVAVMLYYSNFVL--ALEERFGVRPKTTGYLISYTSALGTLAGFAVGPILRlyKHN 341
Cdd:COG2807  216 ------------LAW---LLTLFFGLQSLLYYAVVAWlpPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLAD--RLG 278

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817386 342 SHMVLLHSSALTCLLLLLYSTTNSMAMVVLSSTLLSFSTTIGRT-CITDLQLSVGGAQASGTVIGVGQSVTAVGRILAPL 420
Cdd:COG2807  279 DRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPlALTLIGLRARTPAEAAALSGMAQSVGYLLAALGPL 358

                        410       420       430
                 ....*....|....*....|....*....|
gi 157817386 421 LSGLAQEISpcGPPSLGAALALVAILIMTL 450
Cdd:COG2807  359 LVGALHDAT--GSWTAALLLLAALAVLMLV 386
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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