NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|157817903|ref|NP_001101411|]
View 

DDB1- and CUL4-associated factor 12-like protein 1 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 133-327 1.23e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 59.27  E-value: 1.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817903 133 GPLNKVFASQWLNARQVVC-GTKCNTLFVVDVKTDHIMRiplmRDRVPDLSrgppscgIHAVELNPSKTLLATGGENpNS 211
Cdd:cd00200    7 GHTGGVTCVAFSPDGKLLAtGSGDGTIKVWDLETGELLR----TLKGHTGP-------VRDVAASADGTYLASGSSD-KT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817903 212 LAVYQLPTldPVCLGDCQGHRDWIFAIAWMSD-TVAVSGSRDGTVALWKVDPDM----FNG------SIAWHKDAGLPVY 280
Cdd:cd00200   75 IRLWDLET--GECVRTLTGHTSYVSSVAFSPDgRILSSSSRDKTIKVWDVETGKclttLRGhtdwvnSVAFSPDGTFVAS 152

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 157817903 281 AHISPT----DMEAIPKATTNPG-NRKVRALAFSNKNQELGAVSLDGYFHLW 327
Cdd:cd00200  153 SSQDGTiklwDLRTGKCVATLTGhTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 133-327 1.23e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 59.27  E-value: 1.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817903 133 GPLNKVFASQWLNARQVVC-GTKCNTLFVVDVKTDHIMRiplmRDRVPDLSrgppscgIHAVELNPSKTLLATGGENpNS 211
Cdd:cd00200    7 GHTGGVTCVAFSPDGKLLAtGSGDGTIKVWDLETGELLR----TLKGHTGP-------VRDVAASADGTYLASGSSD-KT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817903 212 LAVYQLPTldPVCLGDCQGHRDWIFAIAWMSD-TVAVSGSRDGTVALWKVDPDM----FNG------SIAWHKDAGLPVY 280
Cdd:cd00200   75 IRLWDLET--GECVRTLTGHTSYVSSVAFSPDgRILSSSSRDKTIKVWDVETGKclttLRGhtdwvnSVAFSPDGTFVAS 152

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 157817903 281 AHISPT----DMEAIPKATTNPG-NRKVRALAFSNKNQELGAVSLDGYFHLW 327
Cdd:cd00200  153 SSQDGTiklwDLRTGKCVATLTGhTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 COG2319
WD40 repeat [General function prediction only];
147-329 1.33e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.92  E-value: 1.33e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817903 147 RQVVCGTKCNTLFVVDVKTDHIMRIPlmrdrvpdlsrGPPSCGIHAVELNPSKTLLATGGENpNSLAVYQLPTldPVCLG 226
Cdd:COG2319  259 RLLASGSADGTVRLWDLATGELLRTL-----------TGHSGGVNSVAFSPDGKLLASGSDD-GTVRLWDLAT--GKLLR 324

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817903 227 DCQGHRDWIFAIAWMSD-TVAVSGSRDGTVALWKVDPDMFNGSIAWHKDAglpvyahisptdmeaipkattnpgnrkVRA 305
Cdd:COG2319  325 TLTGHTGAVRSVAFSPDgKTLASGSDDGTVRLWDLATGELLRTLTGHTGA---------------------------VTS 377

                        170       180
                 ....*....|....*....|....
gi 157817903 306 LAFSNKNQELGAVSLDGYFHLWKA 329
Cdd:COG2319  378 VAFSPDGRTLASGSADGTVRLWDL 401
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 224-259 1.21e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 1.21e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 157817903   224 CLGDCQGHRDWIFAIAWMSD-TVAVSGSRDGTVALWK 259
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDgKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
224-258 5.69e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 5.69e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 157817903  224 CLGDCQGHRDWIFAIAWMSD-TVAVSGSRDGTVALW 258
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDgKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 133-327 1.23e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 59.27  E-value: 1.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817903 133 GPLNKVFASQWLNARQVVC-GTKCNTLFVVDVKTDHIMRiplmRDRVPDLSrgppscgIHAVELNPSKTLLATGGENpNS 211
Cdd:cd00200    7 GHTGGVTCVAFSPDGKLLAtGSGDGTIKVWDLETGELLR----TLKGHTGP-------VRDVAASADGTYLASGSSD-KT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817903 212 LAVYQLPTldPVCLGDCQGHRDWIFAIAWMSD-TVAVSGSRDGTVALWKVDPDM----FNG------SIAWHKDAGLPVY 280
Cdd:cd00200   75 IRLWDLET--GECVRTLTGHTSYVSSVAFSPDgRILSSSSRDKTIKVWDVETGKclttLRGhtdwvnSVAFSPDGTFVAS 152

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 157817903 281 AHISPT----DMEAIPKATTNPG-NRKVRALAFSNKNQELGAVSLDGYFHLW 327
Cdd:cd00200  153 SSQDGTiklwDLRTGKCVATLTGhTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 COG2319
WD40 repeat [General function prediction only];
147-329 1.33e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.92  E-value: 1.33e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817903 147 RQVVCGTKCNTLFVVDVKTDHIMRIPlmrdrvpdlsrGPPSCGIHAVELNPSKTLLATGGENpNSLAVYQLPTldPVCLG 226
Cdd:COG2319  259 RLLASGSADGTVRLWDLATGELLRTL-----------TGHSGGVNSVAFSPDGKLLASGSDD-GTVRLWDLAT--GKLLR 324

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817903 227 DCQGHRDWIFAIAWMSD-TVAVSGSRDGTVALWKVDPDMFNGSIAWHKDAglpvyahisptdmeaipkattnpgnrkVRA 305
Cdd:COG2319  325 TLTGHTGAVRSVAFSPDgKTLASGSDDGTVRLWDLATGELLRTLTGHTGA---------------------------VTS 377

                        170       180
                 ....*....|....*....|....
gi 157817903 306 LAFSNKNQELGAVSLDGYFHLWKA 329
Cdd:COG2319  378 VAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
189-327 1.47e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.92  E-value: 1.47e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817903 189 GIHAVELNPSKTLLATGGENpNSLAVYQLPTldPVCLGDCQGHRDWIFAIAWMSD-TVAVSGSRDGTVALWKVDPDMFNG 267
Cdd:COG2319  206 AVRSVAFSPDGKLLASGSAD-GTVRLWDLAT--GKLLRTLTGHSGSVRSVAFSPDgRLLASGSADGTVRLWDLATGELLR 282

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157817903 268 SIAWHKDaglPVYA-HISPT----------------DMEAIPKATTNPGNR-KVRALAFSNKNQELGAVSLDGYFHLW 327
Cdd:COG2319  283 TLTGHSG---GVNSvAFSPDgkllasgsddgtvrlwDLATGKLLRTLTGHTgAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 190-328 5.11e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 57.34  E-value: 5.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817903 190 IHAVELNPSKTLLATGGENpNSLAVYQLPTLDpvCLGDCQGHRDWIFAIAWMSDT-VAVSGSRDGTVALWKVDPDMFNGS 268
Cdd:cd00200  180 VNSVAFSPDGEKLLSSSSD-GTIKLWDLSTGK--CLGTLRGHENGVNSVAFSPDGyLLASGSEDGTIRVWDLRTGECVQT 256

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817903 269 IAWHKDAglpvyahisptdmeaipkattnpgnrkVRALAFSNKNQELGAVSLDGYFHLWK 328
Cdd:cd00200  257 LSGHTNS---------------------------VTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
57-327 4.10e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.30  E-value: 4.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817903  57 GPAAAMATVGAGNAEGSLMLTKRPRRPIAHLSMVNYLKGRALGADGHPGFAGFEGDLRSYGVLRLPELLRERQLTLGPLN 136
Cdd:COG2319    3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817903 137 KVFASqwLNARQVVCGTKCNTLFVVDVKTDHIMRIPlmrdrvpdlsRGPPScGIHAVELNPSKTLLATGGENpNSLAVYQ 216
Cdd:COG2319   83 SVAFS--PDGRLLASASADGTVRLWDLATGLLLRTL----------TGHTG-AVRSVAFSPDGKTLASGSAD-GTVRLWD 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817903 217 LPTldPVCLGDCQGHRDWIFAIAWMSD-TVAVSGSRDGTVALWKVDPDMFNGSIAWHKDaglPVYA-HISPT-------- 286
Cdd:COG2319  149 LAT--GKLLRTLTGHSGAVTSVAFSPDgKLLASGSDDGTVRLWDLATGKLLRTLTGHTG---AVRSvAFSPDgkllasgs 223

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 157817903 287 --------DMEA-IPKATTNPGNRKVRALAFSNKNQELGAVSLDGYFHLW 327
Cdd:COG2319  224 adgtvrlwDLATgKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273
WD40 COG2319
WD40 repeat [General function prediction only];
189-261 1.13e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.15  E-value: 1.13e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157817903 189 GIHAVELNPSKTLLATGGENpNSLAVYQLPTldPVCLGDCQGHRDWIFAIAWMSD-TVAVSGSRDGTVALWKVD 261
Cdd:COG2319  332 AVRSVAFSPDGKTLASGSDD-GTVRLWDLAT--GELLRTLTGHTGAVTSVAFSPDgRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
165-421 1.22e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 50.68  E-value: 1.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817903 165 TDHIMRIPLMRDRVPDLSRGPPSCGIHAVELNPSKTLLATGGeNPNSLAVYQLPTldPVCLGDCQGHRDWIFAIAWMSD- 243
Cdd:COG2319   56 GDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASAS-ADGTVRLWDLAT--GLLLRTLTGHTGAVRSVAFSPDg 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817903 244 TVAVSGSRDGTVALWKVDPDMFNGSIAWHKDAglpvyahisptdmeaipkattnpgnrkVRALAFSNKNQELGAVSLDGY 323
Cdd:COG2319  133 KTLASGSADGTVRLWDLATGKLLRTLTGHSGA---------------------------VTSVAFSPDGKLLASGSDDGT 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817903 324 FHLWKARSSLSRLLSLRLPYCRENVCltycdeFS----LYAVGSQSH-VSFLDLRQGQqnipPLCSREGGTG-VRSLSVH 397
Cdd:COG2319  186 VRLWDLATGKLLRTLTGHTGAVRSVA------FSpdgkLLASGSADGtVRLWDLATGK----LLRTLTGHSGsVRSVAFS 255

                        250       260
                 ....*....|....*....|....*..
gi 157817903 398 ---QHIVTvGTGHGSLLFYDIRAQKFL 421
Cdd:COG2319  256 pdgRLLAS-GSADGTVRLWDLATGELL 281
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 189-259 6.42e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.10  E-value: 6.42e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157817903 189 GIHAVELNPSKTLLATGGENpNSLAVYQLptLDPVCLGDCQGHRDWIFAIAWMSD-TVAVSGSRDGTVALWK 259
Cdd:cd00200  221 GVNSVAFSPDGYLLASGSED-GTIRVWDL--RTGECVQTLSGHTNSVTSLAWSPDgKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 224-259 1.21e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 1.21e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 157817903   224 CLGDCQGHRDWIFAIAWMSD-TVAVSGSRDGTVALWK 259
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDgKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
224-258 5.69e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 5.69e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 157817903  224 CLGDCQGHRDWIFAIAWMSD-TVAVSGSRDGTVALW 258
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDgKLLASGSDDGTVKVW 38
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 224-263 1.43e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.78  E-value: 1.43e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 157817903 224 CLGDCQGHRDWIFAIAWMSDT-VAVSGSRDGTVALWKVDPD 263
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGkLLATGSGDGTIKVWDLETG 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH