Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....*
gi 157821801  434 LKRHMRSHTGERPYPCEICGKKFTR 458
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26

FOG: Zn-finger [General function prediction only];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821801 362 LHQATAVANLRAALMSKNSLLSLKaDVLGDDGSLLFEYLPKGAHSLSLNEfTVIRKKFKCPYCSFSAMHQCILKRHMRS- 440
Cdd:COG5048  235 LSPKSLLSQSPSSLSSSDSSSSAS-ESPRSSLPTASSQSSSPNESDSSSE-KGFSLPIKSKQCNISFSRSSPLTRHLRSv 312

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 157821801 441 -HTGE--RPYPC--EICGKKFTRREHMKRHTLVHSKDKKYVCK--VCSRVFMSA 487
Cdd:COG5048  313 nHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPL 366

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821801   21 LNEQRQHGVLCDVCVVVEGKVFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVThLDIVTAQGFKAIIDFMYSAHLaLTSR 100
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEIT-LDDVSPEDFEALLEFMYTGKL-ISEE 78

                          90       100
                  ....*....|....*....|....*..
gi 157821801  101 NVIEVMSAASFLQMTDIVQACHDFIKA 127
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFLIK 105

hypothetical protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821801   7 DMEITSHYRHLLRELNEQRQHGVLCDVCVVV-EGKVFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVTHLDIVTAQGFKA 85
Cdd:PHA02713   2 DIDDIKHNRRVVSNISNLLDDDILCDVIITIgDGEEIKAHKTILAAGSKYFRTLFTTPMIIRDLVTRVNLQMFDKDAVKN 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 157821801  86 IIDFMYSAHlaLTSRNVIEVMSAASFLQMTDIVQACHDFIK 126
Cdd:PHA02713  82 IVQYLYNRH--ISSMNVIDVLKCADYLLIDDLVTDCESYIK 120

C2H2-type zinc-finger domain;

                          10        20
                  ....*....|....*....|....*
gi 157821801  419 FKCPYCSFSAMHQCILKRHMRSHTG 443
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHTG 25

FOG: Zn-finger [General function prediction only];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821801 362 LHQATAVANLRAALMSKNSLLSLKaDVLGDDGSLLFEYLPKGAHSLSLNEfTVIRKKFKCPYCSFSAMHQCILKRHMRS- 440
Cdd:COG5048  235 LSPKSLLSQSPSSLSSSDSSSSAS-ESPRSSLPTASSQSSSPNESDSSSE-KGFSLPIKSKQCNISFSRSSPLTRHLRSv 312

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 157821801 441 -HTGE--RPYPC--EICGKKFTRREHMKRHTLVHSKDKKYVCK--VCSRVFMSA 487
Cdd:COG5048  313 nHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPL 366

Modified RING finger, HC subclass (C4C4-type), found in HOIL-1-interacting protein (HOIP) and similar proteins; HOIP, also known as RING finger protein 31 (RNF31) or zinc in-between-RING-finger ubiquitin-associated domain protein, together with HOIL-1 and SHARPIN, forms the E3-ligase complex (also known as linear-ubiquitin-chain assembly complex LUBAC) that regulates NF-kappaB activity and apoptosis. It also interacts with the atypical mammalian orphan receptor DAX-1, trigger DAX-1 ubiquitination and stabilization, and participate in repressing steroidogenic gene expression. HOIP contains three Npl4 zinc fingers, a central ubiquitin-associated (UBA) domain responsible for the interaction with the N-terminal ubiquitin-like domain (UBL) of HOIL-1L, an RBR domain, and a C-terminal linear chain determining domain (LDD). The RBR domain was previously known as RING-BetweenRING-RING domain or TRIAD [two RING fingers and a DRIL (double RING finger linked)] domain. Based on current understanding of the structural biology of RBR ligases, the nomenclature of RBR has been corrected as RING-BRcat (benign-catalytic)-Rcat (required-for-catalysis) recently. The RBR (RING1-BRcat-Rcat) domain uses an auto-inhibitory mechanism to modulate ubiquitination activity, as well as a hybrid mechanism that combines aspects from both RING and HECT E3 ligase function to facilitate the ubiquitination reaction. This model corresponds to the RING domain, a C4C4-type RING finger motif whose overall folding is similar to that of the C3HC4-type RING-HC finger. It is required for RBR-mediated ubiquitination.

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 157821801 447 YPCEICGKKFTRRehmKRHTLVHSKdkkyvCKVCSRVFMSAASVGIKHGSRRHGVCADC 505
Cdd:cd16631    1 QECPICFNSFPRN---KMVSLTSCE-----CKICPDCFKQYFTVVIKEKHIRDLVCPAC 51

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821801  12 SHYRHLLRELNEQRQHGVLCDVCVVVEGKVFKAHKNVLLGSSRYFKTLYCQVQKTS-DQATVTHLDIVTAQGFKAIIDFM 90
Cdd:cd18201    3 SYCYQLLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKEScDQTTVTHLDVVAVQGFSVILDFM 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 157821801  91 YSAHLALTSRNVIEVMSAASFLQMTDIVQACHDFIKAALD 130
Cdd:cd18201   83 YSGNLVLTSQNAIEVMSVASYLQMTEVVQSCRNFIKDALN 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821801  10 ITSHYRHLLRELNEQRQHGVLCDVCVVVEGKVFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVTHLDIVTAQGFKAIIDF 89
Cdd:cd18329    1 ISSHQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVATFDVFSPDTFTIILDF 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 157821801  90 MYSAHLALTSRNVIEVMSAASFLQMTDIVQACHDFI 125
Cdd:cd18329   81 VYSGKLSLTSQNVIEVMSAASYLQMTDVISVCKTFI 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821801  13 HYRHLLRELNEQRQHGVLCDVCVVVEGKVFKAHKNVLLGSSRYFKTLYCqvqktsDQATVTHLDIVTAQGFKAIIDFMYS 92
Cdd:cd18206    5 HSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFV------DQKDVVHLDISNAAGLGQVLEFMYT 78

                         90       100       110
                 ....*....|....*....|....*....|...
gi 157821801  93 AHLALTSRNVIEVMSAASFLQMTDIVQACHDFI 125
Cdd:cd18206   79 AKLSLSPENVDDVLAVATFLQMQDIVTACHALK 111

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821801   21 LNEQRQHGVLCDVCVVVEGKVFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVThLDIVTAQGFKAIIDFMYSAHLaLTSR 100
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEIT-LDDVSPEDFEALLEFMYTGKL-ISEE 78

                          90       100
                  ....*....|....*....|....*..
gi 157821801  101 NVIEVMSAASFLQMTDIVQACHDFIKA 127
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFLIK 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821801  12 SHYRHLLRELNEQRQHGVLCDVCVVVEGKVFKAHKNVLLGSSRYFKTLYC------QVQKTSDQATVTHLDIVTAQGFKA 85
Cdd:cd18228    1 SHSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVgqasprLVLVSPAGKCVLDLHHVTVTGFAP 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 157821801  86 IIDFMYSAHLALTSRNVIEVMSAASFLQMTDIVQACHDFIKAAL 129
Cdd:cd18228   81 LLEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSSI 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821801   8 MEITSHYRHLLRELNEQRQHGVLCDVCVVVEGKVFKAHKNVLLGSSRYFKTLYcqvQKTSDQATVTHL--DIVTAQGFKA 85
Cdd:cd18324    1 MEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFY---KDQLDKRDIVHLnsDIVTAPAFAL 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 157821801  86 IIDFMYSAHLALTSRNVIEVMSAASFLQMTDIVQACHDFIKAALDISIKSDASDE 140
Cdd:cd18324   78 LLEFMYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEKATTEADSTKKEE 132

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821801  13 HYRHLLRELNEQRQHGVLCDVCVVVEGKVFKAHKNVLLGSSRYFKTLYcqvqKTSDQATVThLD--IVTAQGFKAIIDFM 90
Cdd:cd18217    1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQY----KDTEDNIVF-LDqsQVSADGFQKLLEFI 75

                         90       100       110
                 ....*....|....*....|....*....|.
gi 157821801  91 YSAHLALTSRNVIEVMSAASFLQMTDIVQAC 121
Cdd:cd18217   76 YTGNLNLDSWNVAEIHQAASYLGMEEVVAKC 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821801   8 MEITSHYRHLLRELNEQRQHGVLCDVCVVVEGKVFKAHKNVLLGSSRYFKTLYcqvQKTSDQATVTHL--DIVTAQGFKA 85
Cdd:cd18325    1 MEFPDHSRQLLQCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFHLFY---RDQLDKRDIVHLnsDIVTAPAFSL 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 157821801  86 IIDFMYSAHLALTSRNVIEVMSAASFLQMTDIVQACHDFIK 126
Cdd:cd18325   78 LLEFMYEGKLEFSSLPVEDVLAAASYLHMYDIVKVCKGKLK 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821801  13 HYRHLLRELNEQRQHGVLCDVCVVVEGKVFKAHKNVLLGSSRYFKTLYCQvQKTSDQATVTHLDIVTAQGFKAIIDFMYS 92
Cdd:cd18198    8 HSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTS-GAVVDQQNVYEIDFVSPEALTALLEFAYT 86

                         90       100       110
                 ....*....|....*....|....*....|....
gi 157821801  93 AHLALTSRNVIEVMSAASFLQMTDIVQACHDFIK 126
Cdd:cd18198   87 ATLTVSTANVGDILSAARLLEIPCVSHVCAEILD 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821801  17 LLRELNEQRQHGVLCDVCVVVEGKVFKAHKNVLLGSSRYFKTLYC-QVQKTSDQATVTHLDIVTAQGFKAIIDFMYSAHL 95
Cdd:cd18245    1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNyNPPKDDGSTYKIELEGISVEVMEEILDYIYTGQI 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 157821801  96 ALTSRNVIEVMSAASFLQMTDIVQACHDFIK 126
Cdd:cd18245   81 KLSEDNIQDIVQAADLLLMTDLKDLCCEFLE 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821801  12 SHYRHLLRELNEQRQHGVLCDVCVVVEGKVFKAHKNVLLGSSRYFKTLYcQVQKTSDQATVTHLDIVTAQGFKAIIDFMY 91
Cdd:cd18328    7 NHSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLF-TAGTLADQPYVYEIDFVTPEALSAILEFAY 85

                         90       100       110
                 ....*....|....*....|....*....|....
gi 157821801  92 SAHLALTSRNVIEVMSAASFLQMTDIVQACHDFI 125
Cdd:cd18328   86 TSTLTITTSNVKHILNAAQMLEIQCIINVCLEIM 119

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821801    32 DVCVVVEGKVFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVThLDIVTAQGFKAIIDFMYSAHLALTSRNVIEVMSAASF 111
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIY-LDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                           90
                   ....*....|....*
gi 157821801   112 LQMTDIVQACHDFIK 126
Cdd:smart00225  80 LQIPGLVELCEEFLL 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821801  21 LNEQRQHGVLCDVCVVVEGKVFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVTHLDIvTAQGFKAIIDFMYSAHLALTSR 100
Cdd:cd18238    6 LHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDI-DEEAVELLVDFAYTGKLTLTVD 84

                         90       100       110
                 ....*....|....*....|....*....|..
gi 157821801 101 NVIEVMSAASFLQMTDIVQACHDFIKAALDIS 132
Cdd:cd18238   85 NVQSLLYAASLLQVEEVAKACCEFMKDHLHPS 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821801  13 HYRHLLRELNEQRQHGVLCDVCVVVEGKVFKAHKNVLLGSSRYFKTLYcqvqktSDQATVTHLDIVTAQG-----FKAII 87
Cdd:cd18256    3 HASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALF------AGGMSESSKDVVQIHGvepdiFHILL 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 157821801  88 DFMYSAHLALTSRNVIEVMSAASFLQMTDIVQACHDFIKAALDIS 132
Cdd:cd18256   77 DFIYTGVVEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQLHPS 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821801  13 HYRHLLRELNEQRQHGVLCDVCVVVEGKVFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVtHLDIVTAQGFKAIIDFMYS 92
Cdd:cd18257    1 HSEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEV-EFQCIDETALQAIVEYAYT 79

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 157821801  93 AHLALTSRNVIEVMSAASFLQMTDIVQACHDFIKAALD 130
Cdd:cd18257   80 GTVFISQATVESLLPAANLLQIKLVLKECCDFLESQLD 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821801  12 SHYRHLLRELNEQRQHGVLCDVCVVVEGKVFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVtHLDIVTAQGFKAIIDFMY 91
Cdd:cd18242    3 SHAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEV-ELQGLTASTMEILLDFVY 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 157821801  92 SAHLALTSRNVIEVMSAASFLQMTDIVQACHDFIKAALDIS 132
Cdd:cd18242   82 TETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPS 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821801   8 MEITSHYRHLLRELNEQRQHGVLCDVCVVVEGKVFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVTHLDIVTAQGFKAII 87
Cdd:cd18956    1 MEFPEHGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDRPAGGRDTVRLNGDIVTAPAFGRLL 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 157821801  88 DFMYSAHLALTSRNVIEVMSAASFLQMTDIVQACHD 123
Cdd:cd18956   81 DFMYEGRLDLRSLPVEDVLAAASYLHMYDIVKVCKG 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821801  21 LNEQRQ-HGVLCDVCVVV--EGKVFKAHKNVLLGSSRYFKTLYCQVQKTsdQATVTHLDIVTAQGFKAIIDFMYSAHLAL 97
Cdd:cd18231    4 LNEQRLfQPDLCDVDIVLvrQRSTFPAHKGVLAAYSQFFHSLFTQNKQL--QRVELSLEALTSQGLQQILNFIYTSKLLV 81

                         90       100       110
                 ....*....|....*....|....*....|
gi 157821801  98 TSRNVIEVMSAASFLQMTDIVQACHDFIKA 127
Cdd:cd18231   82 NSCNVQDVLNAAAVLQMNDIAASCQELIDS 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821801  13 HYRHLLRELNEQRQHGVLCDVCVVVEGKVFKAHKNVLLGSSRYFKTLY------CQVQKTSDQATVTHLDIVTAQGFKAI 86
Cdd:cd18327    8 HSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFtgggggSGDLGAGGGQDVCELDFVGPEALGAL 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 157821801  87 IDFMYSAHLALTSRNVIEVMSAASFLQMTDIVQACHDFIK 126
Cdd:cd18327   88 LEFAYTATLTISSSNMREVLRAARLLEIPCVADACADILQ 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821801  12 SHYRHLLRELNEQRQHGVLCDVCVVVEGKVFKAHKNVLLGSSRYFKTLYCQVQKTSdQATVTHLDIVTAQGFKAIIDFMY 91
Cdd:cd18264   10 SHGEAVLSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQES-KARVIHLPVVSAAGLQRVLDFIY 88

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 157821801  92 SAHLALTSRNVIEVMSAASFLQMTDIVQACHDFIKAALD 130
Cdd:cd18264   89 TSWLSLSLDTLEDTLEAASYLQVTEAIGLCSQYLINNLA 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821801  14 YRHL---LRELNEQRQHGVLCDVCVVVEGKVFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVtHLDIVTAQGFKAIIDFM 90
Cdd:cd18237    2 AKLLadfMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEV-ELKDAEPDIIELLVEFA 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 157821801  91 YSAHLALTSRNVIEVMSAASFLQMTDIVQACHDFIKAALDIS 132
Cdd:cd18237   81 YTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDAS 122