|
Name |
Accession |
Description |
Interval |
E-value |
| DEXXQc_Helz-like |
cd18038 |
DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and ... |
499-734 |
3.89e-122 |
|
DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and similar proteins. Helicase with zinc finger (HELZ) acts as a helicase that plays a role in RNA metabolism during development. Moloney leukemia virus 10-like protein 1 (Mov10L1) binds Piwi-interacting RNA (piRNA) precursors to initiate piRNA processing. All are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350796 [Multi-domain] Cd Length: 229 Bit Score: 371.57 E-value: 3.89e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 499 ESNPEQLQAMKHIVRGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACTPSNSGADLLCQRLRVHL--PSSI 576
Cdd:cd18038 1 ELNDEQKLAVRNIVTGTSRPPPYIIFGPPGTGKTVTLVEAILQVLRQPPEARILVCAPSNSAADLLAERLLNALvtKREI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 577 YRLLAPSRDIRMVPEDIKTCCNWDpKKGEYVYPAKKHLQQYRVLITTLITASRLVSAQFPIDHFTHIFIDEAGHCMEPES 656
Cdd:cd18038 81 LRLNAPSRDRASVPPELLPYCNSK-AEGTFRLPSLEELKKYRIVVCTLMTAGRLVQAGVPNGHFTHIFIDEAGQATEPEA 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157819123 657 LVAIAglmdvkETGNPGGQLVLAGDPRQLGPVLRSPLAQKHGLGYSLLERLLTYNSLYKKGpnGYDPQFITKLLRNYR 734
Cdd:cd18038 160 LIPLS------ELASKNTQIVLAGDPKQLGPVVRSPLARKYGLGKSLLERLMERPLYYKDG--EYNPSYITKLLKNYR 229
|
|
| SF1_C_Upf1 |
cd18808 |
C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family ... |
735-940 |
2.35e-67 |
|
C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), and similar proteins. They are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350195 [Multi-domain] Cd Length: 184 Bit Score: 223.27 E-value: 2.35e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 735 SHPTILDIPNQLYYDGELQACADVVDRERFCRWEGLpqqGFPIIFHGVMGKDEREGNSPSFFNPEEAATVTSYLRQLLap 814
Cdd:cd18808 1 MHPEISEFPSKLFYEGKLKAGVSVAARLNPPPLPGP---SKPLVFVDVSGGEEREESGTSKSNEAEAELVVELVKYLL-- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 815 sskkgKARLSPRSVGVISPYRKQVEKIRyciTKLDRELRGLDDIKdlkVGSVEEFQGQERSVILISTVRSSQSFVQLdld 894
Cdd:cd18808 76 -----KSGVKPSSIGVITPYRAQVALIR---ELLRKRGGLLEDVE---VGTVDNFQGREKDVIILSLVRSNESGGSI--- 141
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 157819123 895 fnlGFLKNPKRFNVAVTRAKALLIVVGNPLLLGHDPDWKTFLEFCK 940
Cdd:cd18808 142 ---GFLSDPRRLNVALTRAKRGLIIVGNPDTLSKDPLWKKLLEYLE 184
|
|
| AAA_12 |
pfam13087 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
699-923 |
1.46e-61 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.
Pssm-ID: 463780 [Multi-domain] Cd Length: 196 Bit Score: 207.79 E-value: 1.46e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 699 LGYSLLERLLTYNslykkgpngydPQFITKLLRNYRSHPTILDIPNQLYYDGELQACADVVDRERFCrWEGLPQQGFPII 778
Cdd:pfam13087 1 LDRSLFERLQELG-----------PSAVVMLDTQYRMHPEIMEFPSKLFYGGKLKDGPSVAERPLPD-DFHLPDPLGPLV 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 779 FHGVMGKDEREGNS-PSFFNPEEAATVTSYLRQLLAPSSKKgkarlsPRSVGVISPYRKQVEKIRYcitKLDRELRGLDD 857
Cdd:pfam13087 69 FIDVDGSEEEESDGgTSYSNEAEAELVVQLVEKLIKSGPEE------PSDIGVITPYRAQVRLIRK---LLKRKLGGKLE 139
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 157819123 858 IKdlkVGSVEEFQGQERSVILISTVRSSQsfvqldlDFNLGFLKNPKRFNVAVTRAKALLIVVGNP 923
Cdd:pfam13087 140 IE---VNTVDGFQGREKDVIIFSCVRSNE-------KGGIGFLSDPRRLNVALTRAKRGLIIVGNA 195
|
|
| DNA2 |
COG1112 |
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]; |
614-942 |
6.31e-61 |
|
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair];
Pssm-ID: 440729 [Multi-domain] Cd Length: 819 Bit Score: 223.47 E-value: 6.31e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 614 LQQYRVLITTLITASRLVSAQFpiDHFTHIFIDEAGHCMEPESLVAIAglmdvketgnPGGQLVLAGDPRQLGPVLRSPL 693
Cdd:COG1112 532 LELAPVVGMTPASVARLLPLGE--GSFDLVIIDEASQATLAEALGALA----------RAKRVVLVGDPKQLPPVVFGEE 599
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 694 AQK---HGLGYSLLERLLtynslykkgpNGYDPQFITkLLRNYRSHPTILDIPNQLYYDGELQACADVVDRErfcrwegL 770
Cdd:COG1112 600 AEEvaeEGLDESLLDRLL----------ARLPERGVM-LREHYRMHPEIIAFSNRLFYDGKLVPLPSPKARR-------L 661
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 771 PQQGFPIIFHGVMGKDEREGNSPSffNPEEAATVTSYLRQLLapsskkgKARLSPRSVGVISPYRKQVEKIRyciTKLDR 850
Cdd:COG1112 662 ADPDSPLVFIDVDGVYERRGGSRT--NPEEAEAVVELVRELL-------EDGPDGESIGVITPYRAQVALIR---ELLRE 729
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 851 ELRGLDDikDLKVGSVEEFQGQERSVILISTVRSSQSfvqlDLDFNLGFL-KNPKRFNVAVTRAKALLIVVGNPLLLGHD 929
Cdd:COG1112 730 ALGDGLE--PVFVGTVDRFQGDERDVIIFSLVYSNDE----DVPRNFGFLnGGPRRLNVAVSRARRKLIVVGSRELLDSD 803
|
330
....*....|....*.
gi 157819123 930 P---DWKTFLEFCKEN 942
Cdd:COG1112 804 PstpALKRLLEYLERA 819
|
|
| TIGR00376 |
TIGR00376 |
DNA helicase, putative; The gene product may represent a DNA helicase. Eukaryotic members of ... |
486-945 |
5.81e-54 |
|
DNA helicase, putative; The gene product may represent a DNA helicase. Eukaryotic members of this family have been characterized as binding certain single-stranded G-rich DNA sequences (GGGGT and GGGCT). A number of related proteins are characterized as helicases. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273041 [Multi-domain] Cd Length: 636 Bit Score: 199.66 E-value: 5.81e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 486 PSDVKFKLYDRSLesNPEQLQAMKHIVrgtTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKahILACTPSNSGADLLC 565
Cdd:TIGR00376 146 SEIHDFQFFDPNL--NESQKEAVLFAL---SSKDLFLIHGPPGTGKTRTVVELIRQLVKRGLR--VLVTAPSNIAVDNLL 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 566 QRL--------RVHLPSSIY------------------------------------RLLAPSRDIRMVPEDIKTCCNwDP 601
Cdd:TIGR00376 219 ERLalcdqkivRLGHPARLLksnkqhsldylienhpkyqivadirekidelieernKKTKPSPQKRRGLSDIKILRK-AL 297
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 602 KKGEYVYPAKKHLQQYRVLITTLITASRLVSAQFPID--------------------------HFTHIFIDEAGHCMEPE 655
Cdd:TIGR00376 298 KKREARGIESLKIASMAEWIETNKSIDRLLKLLPESEerimneilaesdatnsmagseilngqYFDVAVIDEASQAMEPS 377
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 656 SLVAIaglmdvketgNPGGQLVLAGDPRQLGPVLRSPLAqkHGLGYSLLERLLtynSLYkkgpngydPQFITKLLRNYRS 735
Cdd:TIGR00376 378 CLIPL----------LKARKLILAGDHKQLPPTILSHDA--EELSLTLFERLI---KEY--------PERSRTLNVQYRM 434
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 736 HPTILDIPNQLYYDGELQACADVVDR-------ERFCRWEGLPQQGFPIIFHGVMGKD---EREGNSPSFFNPEEAATVT 805
Cdd:TIGR00376 435 NQKIMEFPSREFYNGKLTAHESVANIllrdlpkVEATESEDDLETGIPLLFIDTSGCElfeLKEADSTSKYNPGEAELVS 514
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 806 SYLRQLLapsskkgKARLSPRSVGVISPYRKQVEKIRYCItkldrELRGLddikDLKVGSVEEFQGQERSVILISTVRSS 885
Cdd:TIGR00376 515 EIIQALV-------KMGVPANDIGVITPYDAQVDLLRQLL-----EHRHI----DIEVSSVDGFQGREKEVIIISFVRSN 578
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 886 QSfvqldldFNLGFLKNPKRFNVAVTRAKALLIVVGNPLLLGHDPDWKTFLEFCKENGGY 945
Cdd:TIGR00376 579 RK-------GEVGFLKDLRRLNVALTRARRKLIVIGDSRTLSNHKFYKRLIEWCKQHGEV 631
|
|
| AAA_11 |
pfam13086 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
504-692 |
8.93e-16 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.
Pssm-ID: 404072 [Multi-domain] Cd Length: 248 Bit Score: 78.15 E-value: 8.93e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 504 QLQAMKHIVRgttRPAPYIIFGPPGTGKTVTLVEAIKQVVKHL-----PKAHILACTPSNSGADLLCQRL---------- 568
Cdd:pfam13086 2 QREAIRSALS---SSHFTLIQGPPGTGKTTTIVELIRQLLSYPatsaaAGPRILVCAPSNAAVDNILERLlrkgqkygpk 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 569 --RVHLPSSI-------------------YRLLAPSRDIRMVPEDIKTC------CNWDPKKGEYVYPAKKHLQQYR--- 618
Cdd:pfam13086 79 ivRIGHPAAIseavlpvsldylvesklnnEEDAQIVKDISKELEKLAKAlrafekEIIVEKLLKSRNKDKSKLEQERrkl 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 619 ---------------------------VLITTLITASRLV---SAQFPIdhfthIFIDEAGHCMEPESLVAIagLMDVKe 668
Cdd:pfam13086 159 rserkelrkelrrreqslereildeaqIVCSTLSGAGSRLlssLANFDV-----VIIDEAAQALEPSTLIPL--LRGPK- 230
|
250 260
....*....|....*....|....
gi 157819123 669 tgnpggQLVLAGDPRQLGPVLRSP 692
Cdd:pfam13086 231 ------KVVLVGDPKQLPPTVISK 248
|
|
| RecD |
COG0507 |
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) ... |
497-688 |
7.30e-11 |
|
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];
Pssm-ID: 440273 [Multi-domain] Cd Length: 514 Bit Score: 65.77 E-value: 7.30e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 497 SLESNPEQLQAMKHIVrgTTRPApYIIFGPPGTGKTvTLVEAIKQVVKHLpKAHILACTPSNSGAdllcQRLR--VHLPS 574
Cdd:COG0507 122 GITLSDEQREAVALAL--TTRRV-SVLTGGAGTGKT-TTLRALLAALEAL-GLRVALAAPTGKAA----KRLSesTGIEA 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 575 S-IYRLLApsrdirmvpediktccnWDPKKGEYVYPAKKHLQQYRVLIttlitasrlvsaqfpidhfthifIDEAghcme 653
Cdd:COG0507 193 RtIHRLLG-----------------LRPDSGRFRHNRDNPLTPADLLV-----------------------VDEA----- 227
|
170 180 190
....*....|....*....|....*....|....*..
gi 157819123 654 peSLVAIAgLMD--VKETGNPGGQLVLAGDPRQLGPV 688
Cdd:COG0507 228 --SMVDTR-LMAalLEALPRAGARLILVGDPDQLPSV 261
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
501-656 |
5.67e-06 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 48.26 E-value: 5.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 501 NPEQLQAMKHIVRGTTRpapYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACTPSNSGADLLCQRLRVHLPSSIYRLL 580
Cdd:smart00487 10 RPYQKEAIEALLSGLRD---VILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVV 86
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157819123 581 A--PSRDIRMVPEDIKTCCnwdpkkgeyvypakkhlqqYRVLITTLITASRLVSAQ-FPIDHFTHIFIDEAgHCMEPES 656
Cdd:smart00487 87 GlyGGDSKREQLRKLESGK-------------------TDILVTTPGRLLDLLENDkLSLSNVDLVILDEA-HRLLDGG 145
|
|
| cdc6 |
PRK00411 |
ORC1-type DNA replication protein; |
503-535 |
6.06e-03 |
|
ORC1-type DNA replication protein;
Pssm-ID: 234751 [Multi-domain] Cd Length: 394 Bit Score: 40.22 E-value: 6.06e-03
10 20 30
....*....|....*....|....*....|....*.
gi 157819123 503 EQLQAMKHIVRGTTR---PAPYIIFGPPGTGKTVTL 535
Cdd:PRK00411 37 EQIEELAFALRPALRgsrPLNVLIYGPPGTGKTTTV 72
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| DEXXQc_Helz-like |
cd18038 |
DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and ... |
499-734 |
3.89e-122 |
|
DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and similar proteins. Helicase with zinc finger (HELZ) acts as a helicase that plays a role in RNA metabolism during development. Moloney leukemia virus 10-like protein 1 (Mov10L1) binds Piwi-interacting RNA (piRNA) precursors to initiate piRNA processing. All are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350796 [Multi-domain] Cd Length: 229 Bit Score: 371.57 E-value: 3.89e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 499 ESNPEQLQAMKHIVRGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACTPSNSGADLLCQRLRVHL--PSSI 576
Cdd:cd18038 1 ELNDEQKLAVRNIVTGTSRPPPYIIFGPPGTGKTVTLVEAILQVLRQPPEARILVCAPSNSAADLLAERLLNALvtKREI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 577 YRLLAPSRDIRMVPEDIKTCCNWDpKKGEYVYPAKKHLQQYRVLITTLITASRLVSAQFPIDHFTHIFIDEAGHCMEPES 656
Cdd:cd18038 81 LRLNAPSRDRASVPPELLPYCNSK-AEGTFRLPSLEELKKYRIVVCTLMTAGRLVQAGVPNGHFTHIFIDEAGQATEPEA 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157819123 657 LVAIAglmdvkETGNPGGQLVLAGDPRQLGPVLRSPLAQKHGLGYSLLERLLTYNSLYKKGpnGYDPQFITKLLRNYR 734
Cdd:cd18038 160 LIPLS------ELASKNTQIVLAGDPKQLGPVVRSPLARKYGLGKSLLERLMERPLYYKDG--EYNPSYITKLLKNYR 229
|
|
| DEXXQc_Mov10L1 |
cd18078 |
DEXXQ-box helicase domain of Mov10L1; Moloney leukemia virus 10-like protein 1 (Mov10L1) binds ... |
501-734 |
1.44e-77 |
|
DEXXQ-box helicase domain of Mov10L1; Moloney leukemia virus 10-like protein 1 (Mov10L1) binds Piwi-interacting RNA (piRNA) precursors to initiate piRNA processing. Mov10L1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350836 [Multi-domain] Cd Length: 230 Bit Score: 253.45 E-value: 1.44e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 501 NPEQLQAMKHIVRGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACTPSNSGADLLCQRL---RVHLPSSIY 577
Cdd:cd18078 3 NELQKEAVKRILGGECRPLPYILFGPPGTGKTVTIIEAILQVVYNLPRSRILVCAPSNSAADLVTSRLhesKVLKPGDMV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 578 RLLAPSRDIRMVPEDIKTCCnwdpKKGEYVYPAKKHlqqyRVLITTLITASRLVSAQFPIDHFTHIFIDEAGHCMEPESL 657
Cdd:cd18078 83 RLNAVNRFESTVIDARKLYC----RLGEDLSKASRH----RIVISTCSTAGLLYQMGLPVGHFTHVFVDEAGQATEPESL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 658 VAIaGLMDVKetgnpGGQLVLAGDPRQLGPVLRSPLAQKHGLGYSLLERLLTYNsLYKKGPN------GYDPQFITKLLR 731
Cdd:cd18078 155 IPL-GLISSR-----DGQIILAGDPMQLGPVIKSRLASAYGLGVSFLERLMNRP-LYLRDPNrfgesgGYNPLLVTKLVD 227
|
...
gi 157819123 732 NYR 734
Cdd:cd18078 228 NYR 230
|
|
| SF1_C_Upf1 |
cd18808 |
C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family ... |
735-940 |
2.35e-67 |
|
C-terminal helicase domain of Upf1-like family helicases; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), and similar proteins. They are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350195 [Multi-domain] Cd Length: 184 Bit Score: 223.27 E-value: 2.35e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 735 SHPTILDIPNQLYYDGELQACADVVDRERFCRWEGLpqqGFPIIFHGVMGKDEREGNSPSFFNPEEAATVTSYLRQLLap 814
Cdd:cd18808 1 MHPEISEFPSKLFYEGKLKAGVSVAARLNPPPLPGP---SKPLVFVDVSGGEEREESGTSKSNEAEAELVVELVKYLL-- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 815 sskkgKARLSPRSVGVISPYRKQVEKIRyciTKLDRELRGLDDIKdlkVGSVEEFQGQERSVILISTVRSSQSFVQLdld 894
Cdd:cd18808 76 -----KSGVKPSSIGVITPYRAQVALIR---ELLRKRGGLLEDVE---VGTVDNFQGREKDVIILSLVRSNESGGSI--- 141
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 157819123 895 fnlGFLKNPKRFNVAVTRAKALLIVVGNPLLLGHDPDWKTFLEFCK 940
Cdd:cd18808 142 ---GFLSDPRRLNVALTRAKRGLIIVGNPDTLSKDPLWKKLLEYLE 184
|
|
| AAA_12 |
pfam13087 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
699-923 |
1.46e-61 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.
Pssm-ID: 463780 [Multi-domain] Cd Length: 196 Bit Score: 207.79 E-value: 1.46e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 699 LGYSLLERLLTYNslykkgpngydPQFITKLLRNYRSHPTILDIPNQLYYDGELQACADVVDRERFCrWEGLPQQGFPII 778
Cdd:pfam13087 1 LDRSLFERLQELG-----------PSAVVMLDTQYRMHPEIMEFPSKLFYGGKLKDGPSVAERPLPD-DFHLPDPLGPLV 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 779 FHGVMGKDEREGNS-PSFFNPEEAATVTSYLRQLLAPSSKKgkarlsPRSVGVISPYRKQVEKIRYcitKLDRELRGLDD 857
Cdd:pfam13087 69 FIDVDGSEEEESDGgTSYSNEAEAELVVQLVEKLIKSGPEE------PSDIGVITPYRAQVRLIRK---LLKRKLGGKLE 139
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 157819123 858 IKdlkVGSVEEFQGQERSVILISTVRSSQsfvqldlDFNLGFLKNPKRFNVAVTRAKALLIVVGNP 923
Cdd:pfam13087 140 IE---VNTVDGFQGREKDVIIFSCVRSNE-------KGGIGFLSDPRRLNVALTRAKRGLIIVGNA 195
|
|
| DNA2 |
COG1112 |
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]; |
614-942 |
6.31e-61 |
|
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair];
Pssm-ID: 440729 [Multi-domain] Cd Length: 819 Bit Score: 223.47 E-value: 6.31e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 614 LQQYRVLITTLITASRLVSAQFpiDHFTHIFIDEAGHCMEPESLVAIAglmdvketgnPGGQLVLAGDPRQLGPVLRSPL 693
Cdd:COG1112 532 LELAPVVGMTPASVARLLPLGE--GSFDLVIIDEASQATLAEALGALA----------RAKRVVLVGDPKQLPPVVFGEE 599
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 694 AQK---HGLGYSLLERLLtynslykkgpNGYDPQFITkLLRNYRSHPTILDIPNQLYYDGELQACADVVDRErfcrwegL 770
Cdd:COG1112 600 AEEvaeEGLDESLLDRLL----------ARLPERGVM-LREHYRMHPEIIAFSNRLFYDGKLVPLPSPKARR-------L 661
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 771 PQQGFPIIFHGVMGKDEREGNSPSffNPEEAATVTSYLRQLLapsskkgKARLSPRSVGVISPYRKQVEKIRyciTKLDR 850
Cdd:COG1112 662 ADPDSPLVFIDVDGVYERRGGSRT--NPEEAEAVVELVRELL-------EDGPDGESIGVITPYRAQVALIR---ELLRE 729
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 851 ELRGLDDikDLKVGSVEEFQGQERSVILISTVRSSQSfvqlDLDFNLGFL-KNPKRFNVAVTRAKALLIVVGNPLLLGHD 929
Cdd:COG1112 730 ALGDGLE--PVFVGTVDRFQGDERDVIIFSLVYSNDE----DVPRNFGFLnGGPRRLNVAVSRARRKLIVVGSRELLDSD 803
|
330
....*....|....*.
gi 157819123 930 P---DWKTFLEFCKEN 942
Cdd:COG1112 804 PstpALKRLLEYLERA 819
|
|
| TIGR00376 |
TIGR00376 |
DNA helicase, putative; The gene product may represent a DNA helicase. Eukaryotic members of ... |
486-945 |
5.81e-54 |
|
DNA helicase, putative; The gene product may represent a DNA helicase. Eukaryotic members of this family have been characterized as binding certain single-stranded G-rich DNA sequences (GGGGT and GGGCT). A number of related proteins are characterized as helicases. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273041 [Multi-domain] Cd Length: 636 Bit Score: 199.66 E-value: 5.81e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 486 PSDVKFKLYDRSLesNPEQLQAMKHIVrgtTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKahILACTPSNSGADLLC 565
Cdd:TIGR00376 146 SEIHDFQFFDPNL--NESQKEAVLFAL---SSKDLFLIHGPPGTGKTRTVVELIRQLVKRGLR--VLVTAPSNIAVDNLL 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 566 QRL--------RVHLPSSIY------------------------------------RLLAPSRDIRMVPEDIKTCCNwDP 601
Cdd:TIGR00376 219 ERLalcdqkivRLGHPARLLksnkqhsldylienhpkyqivadirekidelieernKKTKPSPQKRRGLSDIKILRK-AL 297
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 602 KKGEYVYPAKKHLQQYRVLITTLITASRLVSAQFPID--------------------------HFTHIFIDEAGHCMEPE 655
Cdd:TIGR00376 298 KKREARGIESLKIASMAEWIETNKSIDRLLKLLPESEerimneilaesdatnsmagseilngqYFDVAVIDEASQAMEPS 377
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 656 SLVAIaglmdvketgNPGGQLVLAGDPRQLGPVLRSPLAqkHGLGYSLLERLLtynSLYkkgpngydPQFITKLLRNYRS 735
Cdd:TIGR00376 378 CLIPL----------LKARKLILAGDHKQLPPTILSHDA--EELSLTLFERLI---KEY--------PERSRTLNVQYRM 434
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 736 HPTILDIPNQLYYDGELQACADVVDR-------ERFCRWEGLPQQGFPIIFHGVMGKD---EREGNSPSFFNPEEAATVT 805
Cdd:TIGR00376 435 NQKIMEFPSREFYNGKLTAHESVANIllrdlpkVEATESEDDLETGIPLLFIDTSGCElfeLKEADSTSKYNPGEAELVS 514
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 806 SYLRQLLapsskkgKARLSPRSVGVISPYRKQVEKIRYCItkldrELRGLddikDLKVGSVEEFQGQERSVILISTVRSS 885
Cdd:TIGR00376 515 EIIQALV-------KMGVPANDIGVITPYDAQVDLLRQLL-----EHRHI----DIEVSSVDGFQGREKEVIIISFVRSN 578
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 886 QSfvqldldFNLGFLKNPKRFNVAVTRAKALLIVVGNPLLLGHDPDWKTFLEFCKENGGY 945
Cdd:TIGR00376 579 RK-------GEVGFLKDLRRLNVALTRARRKLIVIGDSRTLSNHKFYKRLIEWCKQHGEV 631
|
|
| DEXXQc_HELZ |
cd18077 |
DEXXQ-box helicase domain of HELZ; Helicase with zinc finger (HELZ) acts as a helicase that ... |
501-734 |
1.24e-32 |
|
DEXXQ-box helicase domain of HELZ; Helicase with zinc finger (HELZ) acts as a helicase that plays a role in RNA metabolism during development. HELZ is a member of the family I class of RNA helicases of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350835 [Multi-domain] Cd Length: 226 Bit Score: 126.45 E-value: 1.24e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 501 NPEQLQAMKHIVRGTTRPAPYI-IFGPPGTGKTVTLVEAIKQVVKHlPKAHILACTPSNSGADLLCQR------LRVHLP 573
Cdd:cd18077 3 NAKQKEAVLAITTPLSIQLPPVlLIGPFGTGKTFTLAQAVKHILQQ-PETRILICTHSNSAADLYIKEylhpyvETGNPR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 574 SSIYRLLAPSRDIRMVPEDIKTCCNWDpKKGEYVYPAKKHLQQYRVLITTLITASRLVSAQFPIDHFTHIFIDEAGHCME 653
Cdd:cd18077 82 ARPLRVYYRNRWVKTVHPVVQKYCLID-EHGTFRMPTREDVMRHRVVVVTLSTSQYLCQLDLEPGFFTHILLDEAAQAME 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 654 PESLVAIAglMDVKETgnpggQLVLAGDPRQLGPVLRSPLAQKHGLGYSLLERLLTYnslykkgpngYDPQF--ITKLLR 731
Cdd:cd18077 161 CEAIMPLA--LATKST-----RIVLAGDHMQLSPEVYSEFARERNLHISLLERLYEH----------YPSEHpcRILLCE 223
|
...
gi 157819123 732 NYR 734
Cdd:cd18077 224 NYR 226
|
|
| DEXXQc_SMUBP2 |
cd18044 |
DEXXQ-box helicase domain of SMUBP2; SMUBP2 (also called immunoglobulin mu-binding protein 2, ... |
522-734 |
2.54e-29 |
|
DEXXQ-box helicase domain of SMUBP2; SMUBP2 (also called immunoglobulin mu-binding protein 2, or IGHMBP2) is a 5' to 3' helicase that unwinds RNA and DNA duplexes in an ATP-dependent reaction. It is a DNA-binding protein specific to 5'-phosphorylated single-stranded guanine-rich sequence (5'-GGGCT-3') related to the immunoglobulin mu chain switch region. The IGHMBP2 gene is responsible for Charcot-Marie-Tooth disease (CMT) type 2S and spinal muscular atrophy with respiratory distress type 1 (SMARD1). It is also thought to play a role in frontotemporal dementia (FTD) with amyotrophic lateral sclerosis (ALS) and major depressive disorder (MDD). SMUBP2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350802 [Multi-domain] Cd Length: 191 Bit Score: 115.78 E-value: 2.54e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 522 IIFGPPGTGKTVTLVEAIKQVVKhlPKAHILACTPSNSGADLLCQRLrVHLPSSIYRLLAPSRdirmVPEDIKTCCnwdp 601
Cdd:cd18044 21 LIHGPPGTGKTTTVVEIILQAVK--RGEKVLACAPSNIAVDNLVERL-VALKVKVVRIGHPAR----LLESVLDHS---- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 602 kkgeyvypaKKHLQQYRVLITTLITASrlvSAQF-PIDHFTHIFIDEAGHCMEPESLVAIAglmdvketgnPGGQLVLAG 680
Cdd:cd18044 90 ---------LDALVAAQVVLATNTGAG---SRQLlPNELFDVVVIDEAAQALEASCWIPLL----------KARRCILAG 147
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 157819123 681 DPRQLGPVLRSPLAQKHGLGYSLLERLLtynslykkgpNGYDPQFITKLLRNYR 734
Cdd:cd18044 148 DHKQLPPTILSDKAARGGLGVTLFERLV----------NLYGESVVRMLTVQYR 191
|
|
| DEXXQc_UPF1 |
cd18039 |
DEXXQ-box helicase domain of UPF1; UPF1 (also called RNA Helicase And ATPase, Regulator Of ... |
501-708 |
6.34e-29 |
|
DEXXQ-box helicase domain of UPF1; UPF1 (also called RNA Helicase And ATPase, Regulator Of Nonsense Transcripts, or ATP-Dependent Helicase RENT1) is an RNA-dependent helicase and ATPase required for nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. It is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. It is recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) located downstream from the termination codon through UPF2 and allows the formation of an UPF1-UPF2-UPF3 surveillance complex which is believed to activate NMD. Diseases associated with UPF1 include juvenile amyotrophic lateral sclerosis and epidermolysis bullosa, junctional, non-Herlitz type. UPF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350797 [Multi-domain] Cd Length: 234 Bit Score: 115.81 E-value: 6.34e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 501 NPEQLQAMKHIVrgtTRPAPYIIfGPPGTGKTVTlveaIKQVVKHLPKAH---ILACTPSNSGADLLCQRL--------- 568
Cdd:cd18039 3 NHSQVDAVKTAL---QRPLSLIQ-GPPGTGKTVT----SATIVYHLVKQGngpVLVCAPSNVAVDQLTEKIhqtglkvvr 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 569 -----RVHLPSSIYrLLAPSRDIRMVPEDIKT------------CCNWDPKKGEYVYPAKKH--LQQYRVLITTLITA-- 627
Cdd:cd18039 75 lcaksREAVESPVS-FLALHNQVRNLDSAEKLellkllkletgeLSSADEKRYRKLKRKAERelLRNADVICCTCVGAgd 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 628 SRLVSAQFPidhftHIFIDEAGHCMEPESLVAIagLMDVKetgnpggQLVLAGDPRQLGPVLRSPLAQKHGLGYSLLERL 707
Cdd:cd18039 154 PRLSKMKFR-----TVLIDEATQATEPECLIPL--VHGAK-------QVILVGDHCQLGPVVMCKKAAKAGLSQSLFERL 219
|
.
gi 157819123 708 L 708
Cdd:cd18039 220 V 220
|
|
| DEXXQc_HELZ2-N |
cd18076 |
N-terminal DEXXQ-box helicase domain of HELZ2; Helicase with zinc finger 2 (HELZ2, also known ... |
501-710 |
7.22e-26 |
|
N-terminal DEXXQ-box helicase domain of HELZ2; Helicase with zinc finger 2 (HELZ2, also known as PPAR-alpha-interacting complex protein 285 or PRIC285 and PPAR-gamma DBD-interacting protein 1 or PDIP1) acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB, and RXRA. It belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350834 [Multi-domain] Cd Length: 230 Bit Score: 106.90 E-value: 7.22e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 501 NPEQLQAMKHIV---RGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHlPKAHILACTPSNSGADLLcqrLRVHLPSSI- 576
Cdd:cd18076 3 NNKQQLAFNFIAgkpSEARFVPPLLIYGPFGTGKTFTLAMAALEVIRE-PGTKVLICTHTNSAADIY---IREYFHPYVd 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 577 --------YRLLAPSRDIRMV-PEDIKTCCNWDPKKGeYVYPAKKHLQQYRVLITTLITASRLVSaqfPIDHFTHIFIDE 647
Cdd:cd18076 79 kghpearpLRIKATDRPNAITdPDTITYCCLTKDRQC-FRLPTRDELDFHNIVITTTAMAFNLHV---LSGFFTHIFIDE 154
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157819123 648 AGHCMEPESLVAIAglmdvkeTGNPGGQLVLAGDPRQLGPVLRSpLAQKHGLGYSLLERLLTY 710
Cdd:cd18076 155 AAQMLECEALIPLS-------YAGPKTRVVLAGDHMQMTPKLFS-VADYNRANHTLLNRLFHY 209
|
|
| DEXXQc_SETX |
cd18042 |
DEXXQ-box helicase domain of SETX; The RNA/DNA helicase senataxin (SETX) plays a role in ... |
501-707 |
2.41e-18 |
|
DEXXQ-box helicase domain of SETX; The RNA/DNA helicase senataxin (SETX) plays a role in transcription, neurogenesis, and antiviral response. SEXT is an R-loop-associated protein that is thought to function as an RNA/DNA helicase. R-loops consist of RNA/DNA hybrids, formed during transcription when nascent RNA hybridizes to the DNA template strand, displacing the non-template DNA strand. Mutations in SETX are linked to two neurodegenerative disorders: ataxia with oculomotor apraxia type 2 (AOA2) and amyotrophic lateral sclerosis type 4 (ALS4). S. cerevisiae homolog splicing endonuclease 1 (Sen1) is an exclusively nuclear protein, important for nucleolar organization. S. cerevisiae Sen1 and its ortholog, the Schizosaccharomyces pombe Sen1, share conserved domains and belong to the family I class of helicases. Both proteins translocate 5' to 3' and unwind both DNA and RNA duplexes and also RNA/DNA hybrids in vitro. SETX is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438712 [Multi-domain] Cd Length: 218 Bit Score: 84.96 E-value: 2.41e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 501 NPEQLQAMKHIVRGTTRPApyIIFGPPGTGKTVTLVEAI-----------------------KQVVKHLPKAHILACTPS 557
Cdd:cd18042 2 NESQLEAIASALQNSPGIT--LIQGPPGTGKTKTIVGILsvllagkyrkyyekvkkklrklqRNLNNKKKKNRILVCAPS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 558 NSGADLLCQRLRVHLPSSIYRLLAPSRDIRMVPEDIKtccnwdpkkgeyvypaKKHLQQYRVLITTLITA-SRLVSAqfP 636
Cdd:cd18042 80 NAAVDEIVLRLLSEGFLDGDGRSYKPNVVRVGRQELR----------------ASILNEADIVCTTLSSSgSDLLES--L 141
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157819123 637 IDHFTHIFIDEAGHCMEPESLVAIAglMDVKetgnpggQLVLAGDPRQLGPVLRSPLAQKHGLGYSLLERL 707
Cdd:cd18042 142 PRGFDTVIIDEAAQAVELSTLIPLR--LGCK-------RLILVGDPKQLPATVFSKVAQKLGYDRSLFERL 203
|
|
| DEXXc_HELZ2-C |
cd18040 |
C-terminal DEXX-box helicase domain of HELZ2; Helicase with zinc finger 2 (HELZ2, also known ... |
501-707 |
8.30e-17 |
|
C-terminal DEXX-box helicase domain of HELZ2; Helicase with zinc finger 2 (HELZ2, also known as PPAR-alpha-interacting complex protein 285 or PRIC285 and PPAR-gamma DBD-interacting protein 1 or PDIP1) acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA. It belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350798 [Multi-domain] Cd Length: 271 Bit Score: 81.80 E-value: 8.30e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 501 NPEQLQAMKhivRGTTRPApYIIFGPPGTGKTVTLV-----------EAIKQVVKHLPKAHILACTPSNSGAD----LLC 565
Cdd:cd18040 3 NPSQNHAVR---TALTKPF-TLIQGPPGTGKTVTGVhiaywfakqnrEIQSVSGEGDGGPCVLYCGPSNKSVDvvaeLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 566 QR-----LRVH----------LPSSIYRLLAPSRD----------------IRMVP----EDIKTCCNWDPKKGEYVypA 610
Cdd:cd18040 79 KVpglkiLRVYseqietteypIPNEPRHPNKKSEReskpnselssitlhhrIRQPSnphsQQIKAFEARFERTQEKI--T 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 611 KKHLQQYRVLITT------------LITASRLVSAQF-PIDHFTHIFIDEAGHCMEPESLVAIAGLMDVKetgnpggQLV 677
Cdd:cd18040 157 EEDIKTYKILIWEarfeeletvdviLCTCSEAASQKMrTHANVKQCIVDECGMCTEPESLIPIVSAPRAE-------QVV 229
|
250 260 270
....*....|....*....|....*....|
gi 157819123 678 LAGDPRQLGPVLRSPLAQKHGLGYSLLERL 707
Cdd:cd18040 230 LIGDHKQLRPVVQNKEAQKLGLGRSLFERY 259
|
|
| AAA_11 |
pfam13086 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
504-692 |
8.93e-16 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.
Pssm-ID: 404072 [Multi-domain] Cd Length: 248 Bit Score: 78.15 E-value: 8.93e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 504 QLQAMKHIVRgttRPAPYIIFGPPGTGKTVTLVEAIKQVVKHL-----PKAHILACTPSNSGADLLCQRL---------- 568
Cdd:pfam13086 2 QREAIRSALS---SSHFTLIQGPPGTGKTTTIVELIRQLLSYPatsaaAGPRILVCAPSNAAVDNILERLlrkgqkygpk 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 569 --RVHLPSSI-------------------YRLLAPSRDIRMVPEDIKTC------CNWDPKKGEYVYPAKKHLQQYR--- 618
Cdd:pfam13086 79 ivRIGHPAAIseavlpvsldylvesklnnEEDAQIVKDISKELEKLAKAlrafekEIIVEKLLKSRNKDKSKLEQERrkl 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 619 ---------------------------VLITTLITASRLV---SAQFPIdhfthIFIDEAGHCMEPESLVAIagLMDVKe 668
Cdd:pfam13086 159 rserkelrkelrrreqslereildeaqIVCSTLSGAGSRLlssLANFDV-----VIIDEAAQALEPSTLIPL--LRGPK- 230
|
250 260
....*....|....*....|....
gi 157819123 669 tgnpggQLVLAGDPRQLGPVLRSP 692
Cdd:pfam13086 231 ------KVVLVGDPKQLPPTVISK 248
|
|
| DEXXQc_Upf1-like |
cd17934 |
DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, ... |
522-734 |
3.48e-14 |
|
DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), coronavirus Nsp13, and similar proteins. They belong to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438708 [Multi-domain] Cd Length: 121 Bit Score: 69.96 E-value: 3.48e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 522 IIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACTPSNSgadllcqrlrvhlpssiyrllapsrdirmvpediktccnwdp 601
Cdd:cd17934 3 LIQGPPGTGKTTTIAAIVLQLLKGLRGKRVLVTAQSNV------------------------------------------ 40
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 602 kkgeyvypakkhlqqyrvlittlitasrlvsaqfPIDHFTHIFIDEAGHCMEPESLVAIAGlmdvketgnpGGQLVLAGD 681
Cdd:cd17934 41 ----------------------------------AVDNVDVVIIDEASQITEPELLIALIR----------AKKVVLVGD 76
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 157819123 682 PRQLGPVLRSPLAQKHGLGYSLLERLLTYNSLykkgpNGYDPQFitkLLRNYR 734
Cdd:cd17934 77 PKQLPPVVQEDHAALLGLSFILSLLLLFRLLL-----PGSPKVM---LDTQYR 121
|
|
| DEXXQc_DNA2 |
cd18041 |
DEXXQ-box helicase domain of DNA2; DNA2 (DNA Replication Helicase/Nuclease 2) possesses ... |
501-734 |
1.17e-13 |
|
DEXXQ-box helicase domain of DNA2; DNA2 (DNA Replication Helicase/Nuclease 2) possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5-3 helicase, and endonuclease activities, and is involved in DNA replication and DNA repair in the nucleus and mitochondrion. It is involved in Okazaki fragment processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. It is also involved in 5-end resection of DNA during double-strand break (DSB) repair; it is recruited by BLM and mediates the cleavage of 5-ssDNA, while the 3-ssDNA cleavage is prevented by the presence of RPA. DNA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350799 [Multi-domain] Cd Length: 203 Bit Score: 70.73 E-value: 1.17e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 501 NPEQLQAMKHIVRGTTrpapY-IIFGPPGTGKTVTLVEAIKqvVKHLPKAHILACTPSNSGADLLCQRLRVHlPSSIYRL 579
Cdd:cd18041 3 NKDQRQAIKKVLNAKD----YaLILGMPGTGKTTTIAALVR--ILVALGKSVLLTSYTHSAVDNILLKLKKF-GVNFLRL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 580 lapSRDIRMVPEDIKTCCNWDPKKGEYVYPAKKHLQQYRVLITTLITasrlvsaqfpIDHftHIF---------IDEAGH 650
Cdd:cd18041 76 ---GRLKKIHPDVQEFTLEAILKSCKSVEELESKYESVSVVATTCLG----------INH--PIFrrrtfdyciVDEASQ 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 651 CMEPESLVAIAGlmdvketgnpGGQLVLAGDPRQLGPVLRSPLAQKHGLGYSLLERLLtynslyKKGPNGydpqfITKLL 730
Cdd:cd18041 141 ITLPICLGPLRL----------AKKFVLVGDHYQLPPLVKSREARELGMDESLFKRLS------EAHPDA-----VVQLT 199
|
....
gi 157819123 731 RNYR 734
Cdd:cd18041 200 IQYR 203
|
|
| RecD |
COG0507 |
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) ... |
497-688 |
7.30e-11 |
|
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];
Pssm-ID: 440273 [Multi-domain] Cd Length: 514 Bit Score: 65.77 E-value: 7.30e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 497 SLESNPEQLQAMKHIVrgTTRPApYIIFGPPGTGKTvTLVEAIKQVVKHLpKAHILACTPSNSGAdllcQRLR--VHLPS 574
Cdd:COG0507 122 GITLSDEQREAVALAL--TTRRV-SVLTGGAGTGKT-TTLRALLAALEAL-GLRVALAAPTGKAA----KRLSesTGIEA 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 575 S-IYRLLApsrdirmvpediktccnWDPKKGEYVYPAKKHLQQYRVLIttlitasrlvsaqfpidhfthifIDEAghcme 653
Cdd:COG0507 193 RtIHRLLG-----------------LRPDSGRFRHNRDNPLTPADLLV-----------------------VDEA----- 227
|
170 180 190
....*....|....*....|....*....|....*..
gi 157819123 654 peSLVAIAgLMD--VKETGNPGGQLVLAGDPRQLGPV 688
Cdd:COG0507 228 --SMVDTR-LMAalLEALPRAGARLILVGDPDQLPSV 261
|
|
| DEXSc_RecD-like |
cd17933 |
DEXS-box helicase domain of RecD and similar proteins; RecD is a member of the RecBCD (EC 3.1. ... |
503-688 |
1.19e-08 |
|
DEXS-box helicase domain of RecD and similar proteins; RecD is a member of the RecBCD (EC 3.1.11.5, Exonuclease V) complex. It is the alpha chain of the complex and functions as a 3'-5' helicase. The RecBCD enzyme is both a helicase that unwinds, or separates the strands of DNA, and a nuclease that makes single-stranded nicks in DNA. RecD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350691 [Multi-domain] Cd Length: 155 Bit Score: 54.87 E-value: 1.19e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 503 EQLQAMKHIVRGttrpaPYIIF-GPPGTGKTVTLveaiKQVVKHL--PKAHILACTPSNSGAdllcQRLR--VHLPSS-I 576
Cdd:cd17933 1 EQKAAVRLVLRN-----RVSVLtGGAGTGKTTTL----KALLAALeaEGKRVVLAAPTGKAA----KRLSesTGIEAStI 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 577 YRLLapsrdirmvpediktccNWDPKKGEYVYPAKKHLqQYRVLIttlitasrlvsaqfpidhfthifIDEAghcmepeS 656
Cdd:cd17933 68 HRLL-----------------GINPGGGGFYYNEENPL-DADLLI-----------------------VDEA-------S 99
|
170 180 190
....*....|....*....|....*....|...
gi 157819123 657 LVAIAgLMD-VKETGNPGGQLVLAGDPRQLGPV 688
Cdd:cd17933 100 MVDTR-LMAaLLSAIPAGARLILVGDPDQLPSV 131
|
|
| COG3972 |
COG3972 |
Superfamily I DNA and RNA helicases [Replication, recombination and repair]; |
436-921 |
1.57e-07 |
|
Superfamily I DNA and RNA helicases [Replication, recombination and repair];
Pssm-ID: 443172 [Multi-domain] Cd Length: 565 Bit Score: 55.22 E-value: 1.57e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 436 SRFVDGLTFKVNFTFNRQPLRVQHRALELTGRWVLWPT---------LFPVASRGVSLLPSDVKF-KLYDRSLESNP-EQ 504
Cdd:COG3972 77 SGAEQVVLDGVRALFEVLLQVDRESVRNLTEDHLRSLRllaasrrdfLFALLLPEIPPAPFVQALrLLNLVSLEDFFlPL 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 505 LQAM----KHIVRgTTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACTPSNSgadlLCQRLRVHLPSSIYRLL 580
Cdd:COG3972 157 IAVLdlqqERIAR-SIPDGPQRIRGVAGSGKTVLLAAKAAYLALKHPGWRILVTCFNRS----LADHLRDLIPRFLRRFS 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 581 APSrdirmVPEDIKTCCN--W-DPKKGEYVYPAKKHLQQ---YRVLITTLITASRLVSAQFPIDhftHIFIDEAgHCMEP 654
Cdd:COG3972 232 NGE-----PEDNVKLIVFhaWgGKLLKQYGIPPLTFSQPneaFDEACKALLEAIQGEIIPPIYD---AILIDEA-QDFEP 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 655 ESLVAIAGLMDvketgNPGGQLVLAGDPRQlgpvlrsplaqkhglgysllerlltynSLYKK---GPNGYDPQF--ITKL 729
Cdd:COG3972 303 EFLRLLYQLLK-----PPKKRLIWAYDEAQ---------------------------NIYGRkipSAGGIPAGIgrDTIL 350
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 730 LRNYRSHPTILDIPNQLY-----YDGELQACADVVDRERFcrweglpqqGFPIIFHGVMGKDEREGNSPSFF----NPEE 800
Cdd:COG3972 351 KKNYRNTRPILTFAHAFGmgllrPPGLLQGDAEDYEVERP---------GDKVTLIRPPEPAGRKGPLPEFKkyddRAEE 421
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 801 AATVTSYLRQLLApsskkgKARLSPRSVGVI----SPYRKQVEKIRYCITKLDRELRGLDDIKD---------LKVGSVE 867
Cdd:COG3972 422 LEAIAEEIKKNLR------DEGLRPSDIAVIylgnNEAKELGDRLAAALERQGIDSYIAGARSDpnffwkdggVTISTIH 495
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 157819123 868 EFQGQERSVILISTVRSSQSFVQLDLDFNLGFlknpkrfnVAVTRAKALLIVVG 921
Cdd:COG3972 496 RAKGLEAPVVIIVGLDQLAKGESLERLRNLLY--------VAMTRARGWLVVSG 541
|
|
| EEXXEc_NFX1 |
cd17936 |
EEXXE-box helicase domain of NFX1; Human NFX1 protein was identified as a protein that ... |
501-707 |
2.13e-07 |
|
EEXXE-box helicase domain of NFX1; Human NFX1 protein was identified as a protein that represses class II MHC (major histocompatibility complex) gene expression. NFX1 binds a conserved cis-acting element, termed the X-box, in promoters of human class II MHC genes. The Cys-rich region contains several NFX1-type zinc finger domains. Frequently, a R3H domain is present in the C-terminus, and a RING finger domain and a PAM2 motif are present in the N-terminus. The lack of R3H and PAM2 motifs in the plant proteins indicates functional differences. Plant NFX1-like proteins are proposed to modulate growth and survival by coordinating reactive oxygen species, salicylic acid, further biotic stress and abscisic acid responses. A common feature of all members may be E3 ubiquitin ligase, due to the presence of a RING finger domain, as well as DNA binding. NFX1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350694 [Multi-domain] Cd Length: 178 Bit Score: 51.78 E-value: 2.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 501 NPEQLQAMKHIVrgTTRPApyIIFGPPGTGKT---VTLVEAIKQVVKHLPKAHILACTPSNSGADLLCQRLRVHLPSSIY 577
Cdd:cd17936 3 DPSQLEALKHAL--TSELA--LIQGPPGTGKTflgVKLVRALLQNQDLSITGPILVVCYTNHALDQFLEGLLDFGPTKIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 578 RLLApsRDIRMVpediKTCCnwdpkkgeyvypAKkhlqqYRVLITTLitasrlvsaQFPIdhfthIFIDEAGHCMEPESL 657
Cdd:cd17936 79 RLGA--RVIGMT----TTGA------------AK-----YRELLQAL---------GPKV-----VIVEEAAEVLEAHIL 121
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 157819123 658 VAIaglmdvketGNPGGQLVLAGDPRQLGPVLRSPL--AQKHGLGYSLLERL 707
Cdd:cd17936 122 AAL---------TPSTEHLILIGDHKQLRPKVNVYEltAKKYNLDVSLFERL 164
|
|
| EEXXQc_AQR |
cd17935 |
EEXXQ-box helicase domain of AQR; Aquarius (AQR) is a multifunctional RNA helicase that binds ... |
496-747 |
2.38e-07 |
|
EEXXQ-box helicase domain of AQR; Aquarius (AQR) is a multifunctional RNA helicase that binds precursor-mRNA introns at a defined position and is part of a pentameric intron-binding complex (IBC). It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350693 [Multi-domain] Cd Length: 207 Bit Score: 52.43 E-value: 2.38e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 496 RSLESNPEQLQAmkhIVRGTtRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACTPSNSGADLLCQ---RLRV-- 570
Cdd:cd17935 2 NTVKFTPTQIEA---IRSGM-QPGLTMVVGPPGTGKTDVAVQIISNLYHNFPNQRTLIVTHSNQALNQLFEkimALDIde 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 571 -HLpssiYRLLAPSRDIRMvpedikTCCNWDPKKGEyvypakkhlqqyrvlittlitasrLVSAQFpidHFTHIFIDEAG 649
Cdd:cd17935 78 rHL----LRLGHGAKIIAM------TCTHAALKRGE------------------------LVELGF---KYDNILMEEAA 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 650 HCMEPESLVAIagLMDVKETG-NPGGQLVLAGDPRQLGPVLRSPLAQKHG-LGYSLLERLLTYNSlykkgpngydpqFIT 727
Cdd:cd17935 121 QILEIETFIPL--LLQNPEDGpNRLKRLIMIGDHHQLPPVIKNMAFQKYSnMEQSLFTRLVRLGV------------PTV 186
|
250 260
....*....|....*....|
gi 157819123 728 KLLRNYRSHPTILDIPNQLY 747
Cdd:cd17935 187 DLDAQGRARASISSLYNWRY 206
|
|
| AAA_30 |
pfam13604 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
501-688 |
1.78e-06 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. There is a Walker A and Walker B.
Pssm-ID: 433343 [Multi-domain] Cd Length: 191 Bit Score: 49.48 E-value: 1.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 501 NPEQLQAMKHIVRGTTRPApyIIFGPPGTGKTvTLVEAIKQVVKHLPKaHILACTPSNSGADLLCQRLRVHlPSSIYRLL 580
Cdd:pfam13604 3 NAEQAAAVRALLTSGDRVA--VLVGPAGTGKT-TALKALREAWEAAGY-RVIGLAPTGRAAKVLGEELGIP-ADTIAKLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 581 APSRDIRmvpediktccNWDPKkgeyvypakkhlqqyRVLIttlitasrlvsaqfpidhfthifIDEAGhcmepesLVAI 660
Cdd:pfam13604 78 HRLGGRA----------GLDPG---------------TLLI-----------------------VDEAG-------MVGT 102
|
170 180
....*....|....*....|....*....
gi 157819123 661 AGLMDV-KETGNPGGQLVLAGDPRQLGPV 688
Cdd:pfam13604 103 RQMARLlKLAEDAGARVILVGDPRQLPSV 131
|
|
| SF1_C |
cd18786 |
C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family ... |
826-921 |
4.50e-06 |
|
C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Similar to SF2 helicases, they do not form toroidal, predominantly hexameric structures like SF3-6. SF1 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350173 [Multi-domain] Cd Length: 89 Bit Score: 45.89 E-value: 4.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 826 RSVGVISPYRKQVEKIRYCITKLDRELrglDDIKDLKVGSVEEFQGQERSVILISTVRSsqsfvqldldfnlgFLKNPKR 905
Cdd:cd18786 11 YKGVVLTPYHRDRAYLNQYLQGLSLDE---FDLQLVGAITIDSSQGLTFDVVTLYLPTA--------------NSLTPRR 73
|
90
....*....|....*.
gi 157819123 906 FNVAVTRAKALLIVVG 921
Cdd:cd18786 74 LYVALTRARKRLVIYD 89
|
|
| DExxQc_SF1-N |
cd17914 |
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members ... |
522-711 |
5.17e-06 |
|
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Like SF2, they do not form toroidal, predominantly hexameric structures like SF3-6. Their helicase core is surrounded by C and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains or domains engaged in protein-protein interactions. SF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438706 [Multi-domain] Cd Length: 121 Bit Score: 46.71 E-value: 5.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 522 IIFGPPGTGKTVTLVEAIKQVV--KHLPKAHILACTPSNSGAdllcqrlrvhlpssiyrllapsrdirmvpediktccnw 599
Cdd:cd17914 3 LIQGPPGTGKTRVLVKIVAALMqnKNGEPGRILLVTPTNKAA-------------------------------------- 44
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 600 dpkkgeyvypakkhlqqyrvlittlitasrlvsaqfpiDHFTHIFIDEAGHCMEPESLVAIAGLMDVketgnpgGQLVLA 679
Cdd:cd17914 45 --------------------------------------AQLDNILVDEAAQILEPETSRLIDLALDQ-------GRVILV 79
|
170 180 190
....*....|....*....|....*....|..
gi 157819123 680 GDPRQLGPVLRSPLAQKHGLGYSLLERLLTYN 711
Cdd:cd17914 80 GDHDQLGPVWRGAVLAKICNEQSLFTRLVRLG 111
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
501-656 |
5.67e-06 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 48.26 E-value: 5.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 501 NPEQLQAMKHIVRGTTRpapYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACTPSNSGADLLCQRLRVHLPSSIYRLL 580
Cdd:smart00487 10 RPYQKEAIEALLSGLRD---VILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVV 86
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157819123 581 A--PSRDIRMVPEDIKTCCnwdpkkgeyvypakkhlqqYRVLITTLITASRLVSAQ-FPIDHFTHIFIDEAgHCMEPES 656
Cdd:smart00487 87 GlyGGDSKREQLRKLESGK-------------------TDILVTTPGRLLDLLENDkLSLSNVDLVILDEA-HRLLDGG 145
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
501-650 |
5.14e-04 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 41.89 E-value: 5.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 501 NPEQLQAMKHIVRGT-TRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILactpsnsgadllcqrlrvhlpssiyrL 579
Cdd:pfam04851 5 RPYQIEAIENLLESIkNGQKRGLIVMATGSGKTLTAAKLIARLFKKGPIKKVL--------------------------F 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 580 LAPSRDI---------RMVPEDIKTCCNWDPKKgeyvypAKKHLQQYRVLITT---LITASRLVSAQFPIDHFTHIFIDE 647
Cdd:pfam04851 59 LVPRKDLleqaleefkKFLPNYVEIGEIISGDK------KDESVDDNKIVVTTiqsLYKALELASLELLPDFFDVIIIDE 132
|
...
gi 157819123 648 AGH 650
Cdd:pfam04851 133 AHR 135
|
|
| UvrD |
COG0210 |
Superfamily I DNA or RNA helicase [Replication, recombination and repair]; |
501-581 |
6.61e-04 |
|
Superfamily I DNA or RNA helicase [Replication, recombination and repair];
Pssm-ID: 439980 [Multi-domain] Cd Length: 721 Bit Score: 43.77 E-value: 6.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 501 NPEQLQAMKHIvrgttrPAPYIIFGPPGTGKTVTLVEAIKQVV--KHLPKAHILACTPSNSGADLLCQRLRVHLPSSIYR 578
Cdd:COG0210 8 NPEQRAAVEHP------EGPLLVLAGAGSGKTRVLTHRIAYLIaeGGVDPEQILAVTFTNKAAREMRERIEALLGRLARG 81
|
...
gi 157819123 579 LLA 581
Cdd:COG0210 82 LWV 84
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
522-678 |
3.41e-03 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 38.92 E-value: 3.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 522 IIFGPPGTGKTVTLVEAIKQV-VKHLPKAHILacTPSNSGADLLCQRLRvhlpssiyRLLAPSRDIRMVPEDiktccnwD 600
Cdd:cd00046 5 LITAPTGSGKTLAALLAALLLlLKKGKKVLVL--VPTKALALQTAERLR--------ELFGPGIRVAVLVGG-------S 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 601 PKKGEYVYPakkhLQQYRVLITTLITASRLVSA--QFPIDHFTHIFIDEAgHCMEPESLVAIAGLMDVKETGNPGGQLVL 678
Cdd:cd00046 68 SAEEREKNK----LGDADIIIATPDMLLNLLLRedRLFLKDLKLIIVDEA-HALLIDSRGALILDLAVRKAGLKNAQVIL 142
|
|
| AAA |
smart00382 |
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ... |
517-571 |
4.29e-03 |
|
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.
Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 38.89 E-value: 4.29e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 157819123 517 RPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACTPSNSGADLLCQRLRVH 571
Cdd:smart00382 1 PGEVILIVGPPGSGKTTLARALARELGPPGGGVIYIDGEDILEEVLDQLLLIIVG 55
|
|
| cdc6 |
PRK00411 |
ORC1-type DNA replication protein; |
503-535 |
6.06e-03 |
|
ORC1-type DNA replication protein;
Pssm-ID: 234751 [Multi-domain] Cd Length: 394 Bit Score: 40.22 E-value: 6.06e-03
10 20 30
....*....|....*....|....*....|....*.
gi 157819123 503 EQLQAMKHIVRGTTR---PAPYIIFGPPGTGKTVTL 535
Cdd:PRK00411 37 EQIEELAFALRPALRgsrPLNVLIYGPPGTGKTTTV 72
|
|
| AAA_19 |
pfam13245 |
AAA domain; |
511-688 |
7.14e-03 |
|
AAA domain;
Pssm-ID: 433059 [Multi-domain] Cd Length: 136 Bit Score: 37.97 E-value: 7.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 511 IVRGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVK-HLPKAHILACTPSNSGADLLCQRLrvHLPSS-IYRLLapsrdirm 588
Cdd:pfam13245 4 AVRTALPSKVVLLTGGPGTGKTTTIRHIVALLVAlGGVSFPILLAAPTGRAAKRLSERT--GLPAStIHRLL-------- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819123 589 vpediktccNWDPkkgeyvypakkhlqqyrvlittLITASRLVSAQFPIDHFtHIFIDEAghcmepeSLVAIAGLMDVKE 668
Cdd:pfam13245 74 ---------GFDD----------------------LEAGGFLRDEEEPLDGD-LLIVDEF-------SMVDLPLAYRLLK 114
|
170 180
....*....|....*....|
gi 157819123 669 TGNPGGQLVLAGDPRQLGPV 688
Cdd:pfam13245 115 ALPDGAQLLLVGDPDQLPSV 134
|
|
| |
