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Conserved domains on  [gi|402766086|ref|NP_001101120|]
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DNA excision repair protein ERCC-8 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 42-361 9.15e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 140.55  E-value: 9.15e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086  42 HCSGVNTLDIEPVeGRYMLSGGSDGVIVLYDLENasRQPYYTCKavcsvgrshpdVHKYSVETVQWYPHDTGMFtSSSFD 121
Cdd:cd00200    8 HTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLET--GELLRTLK-----------GHTGPVRDVAASADGTYLA-SGSSD 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086 122 KTLKVWDTNTLQAADVFN-FEETVYSHHMSPAATkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPrYDY 200
Cdd:cd00200   73 KTIRLWDLETGECVRTLTgHTSYVSSVAFSPDGR---ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP-DGT 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086 201 ILATASADSRVKLWDVRRASgCLLTLdqhngkksqavesanTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSSGDNT 280
Cdd:cd00200  149 FVASSSQDGTIKLWDLRTGK-CVATL---------------TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCL 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086 281 lvnygKVCNSSRKGLKFTVSHGCNSEFVFVPYDSTIAMYAVYSGERLAMLKGHYKSVDCCVFQPNFQELYSGSRDCNILA 360
Cdd:cd00200  213 -----GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287


                 .
gi 402766086 361 W 361
Cdd:cd00200  288 W 288
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 42-361 9.15e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 140.55  E-value: 9.15e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086  42 HCSGVNTLDIEPVeGRYMLSGGSDGVIVLYDLENasRQPYYTCKavcsvgrshpdVHKYSVETVQWYPHDTGMFtSSSFD 121
Cdd:cd00200    8 HTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLET--GELLRTLK-----------GHTGPVRDVAASADGTYLA-SGSSD 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086 122 KTLKVWDTNTLQAADVFN-FEETVYSHHMSPAATkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPrYDY 200
Cdd:cd00200   73 KTIRLWDLETGECVRTLTgHTSYVSSVAFSPDGR---ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP-DGT 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086 201 ILATASADSRVKLWDVRRASgCLLTLdqhngkksqavesanTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSSGDNT 280
Cdd:cd00200  149 FVASSSQDGTIKLWDLRTGK-CVATL---------------TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCL 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086 281 lvnygKVCNSSRKGLKFTVSHGCNSEFVFVPYDSTIAMYAVYSGERLAMLKGHYKSVDCCVFQPNFQELYSGSRDCNILA 360
Cdd:cd00200  213 -----GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287


                 .
gi 402766086 361 W 361
Cdd:cd00200  288 W 288
WD40 COG2319
WD40 repeat [General function prediction only];
5-361 6.23e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.81  E-value: 6.23e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086   5 LSARQSGLEDPLRLRRAQSTRRVLGLELNKDRDVERVHCSGVNTLDIEPvEGRYMLSGGSDGVIVLYDLenASRQPYYTC 84
Cdd:COG2319   82 LSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDL--ATGKLLRTL 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086  85 KAvcsvgrshpdvHKYSVETVQWYPhDTGMFTSSSFDKTLKVWDTNTLQAADVFN-FEETVYSHHMSPAATkhcLVAVGT 163
Cdd:COG2319  159 TG-----------HSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGK---LLASGS 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086 164 RGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPrYDYILATASADSRVKLWDVRRASgCLLTLdqhngkksqavesanTA 243
Cdd:COG2319  224 ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGE-LLRTL---------------TG 286

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086 244 HNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSSGD--NTLVNYGKVCNS---SRKGlKFTVSHGcnsefvfvpYDSTIAM 318
Cdd:COG2319  287 HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKllRTLTGHTGAVRSvafSPDG-KTLASGS---------DDGTVRL 356

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 402766086 319 YAVYSGERLAMLKGHYKSVDCCVFQPNFQELYSGSRDCNILAW 361
Cdd:COG2319  357 WDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 175-215 1.99e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 1.99e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 402766086   175 SGSCSHILQGHRQEILAVSWSPRYDYiLATASADSRVKLWD 215
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
176-215 5.05e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 5.05e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 402766086  176 GSCSHILQGHRQEILAVSWSPRYDYiLATASADSRVKLWD 215
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 172-281 4.40e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 45.71  E-value: 4.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086 172 DLKSGSCshILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV---RRA----------------SGCLLTLDQHNGK 232
Cdd:PTZ00420 113 EIKDPQC--ILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIeneKRAfqinmpkklsslkwniKGNLLSGTCVGKH 190

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 402766086 233 ------KSQAVESANTAHNGKVNGLCFTSDGL-----HLLTVG-TDNRMR---LW---NSSSGDNTL 281
Cdd:PTZ00420 191 mhiidpRKQEIASSFHIHDGGKNTKNIWIDGLggddnYILSTGfSKNNMRemkLWdlkNTTSALVTM 257
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 42-361 9.15e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 140.55  E-value: 9.15e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086  42 HCSGVNTLDIEPVeGRYMLSGGSDGVIVLYDLENasRQPYYTCKavcsvgrshpdVHKYSVETVQWYPHDTGMFtSSSFD 121
Cdd:cd00200    8 HTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLET--GELLRTLK-----------GHTGPVRDVAASADGTYLA-SGSSD 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086 122 KTLKVWDTNTLQAADVFN-FEETVYSHHMSPAATkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPrYDY 200
Cdd:cd00200   73 KTIRLWDLETGECVRTLTgHTSYVSSVAFSPDGR---ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP-DGT 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086 201 ILATASADSRVKLWDVRRASgCLLTLdqhngkksqavesanTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSSGDNT 280
Cdd:cd00200  149 FVASSSQDGTIKLWDLRTGK-CVATL---------------TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCL 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086 281 lvnygKVCNSSRKGLKFTVSHGCNSEFVFVPYDSTIAMYAVYSGERLAMLKGHYKSVDCCVFQPNFQELYSGSRDCNILA 360
Cdd:cd00200  213 -----GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287


                 .
gi 402766086 361 W 361
Cdd:cd00200  288 W 288
WD40 COG2319
WD40 repeat [General function prediction only];
5-361 6.23e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.81  E-value: 6.23e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086   5 LSARQSGLEDPLRLRRAQSTRRVLGLELNKDRDVERVHCSGVNTLDIEPvEGRYMLSGGSDGVIVLYDLenASRQPYYTC 84
Cdd:COG2319   82 LSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDL--ATGKLLRTL 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086  85 KAvcsvgrshpdvHKYSVETVQWYPhDTGMFTSSSFDKTLKVWDTNTLQAADVFN-FEETVYSHHMSPAATkhcLVAVGT 163
Cdd:COG2319  159 TG-----------HSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGK---LLASGS 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086 164 RGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPrYDYILATASADSRVKLWDVRRASgCLLTLdqhngkksqavesanTA 243
Cdd:COG2319  224 ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGE-LLRTL---------------TG 286

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086 244 HNGKVNGLCFTSDGLHLLTVGTDNRMRLWNSSSGD--NTLVNYGKVCNS---SRKGlKFTVSHGcnsefvfvpYDSTIAM 318
Cdd:COG2319  287 HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKllRTLTGHTGAVRSvafSPDG-KTLASGS---------DDGTVRL 356

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 402766086 319 YAVYSGERLAMLKGHYKSVDCCVFQPNFQELYSGSRDCNILAW 361
Cdd:COG2319  357 WDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
5-369 9.40e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.78  E-value: 9.40e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086   5 LSARQSGLEDPLRLRRAQSTRRVLGLELNKDRDVERVHCSGVNTLDIEPvEGRYMLSGGSDGVIVLYDLENASRqpyytc 84
Cdd:COG2319   40 ASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLL------ 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086  85 kavcsvgRSHPDVHKYSVETVQWYPhDTGMFTSSSFDKTLKVWDTNTLQAADVFN-FEETVYSHHMSPAATkhcLVAVGT 163
Cdd:COG2319  113 -------LRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTLTgHSGAVTSVAFSPDGK---LLASGS 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086 164 RGPKVQLCDLKSGSCSHILQGHRQEILAVSWSP--RYdyiLATASADSRVKLWDVRRASgCLLTLdqhngkksqavesan 241
Cdd:COG2319  182 DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPdgKL---LASGSADGTVRLWDLATGK-LLRTL--------------- 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086 242 TAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWNsssgdntlvnygkvcnssrkglkftvshgcnsefvfvpydstiamyaV 321
Cdd:COG2319  243 TGHSGSVRSVAFSPDGRLLASGSADGTVRLWD-----------------------------------------------L 275

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 402766086 322 YSGERLAMLKGHYKSVDCCVFQPNFQELYSGSRDCNILAWVPASYEPV 369
Cdd:COG2319  276 ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL 323
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 42-273 2.88e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 112.43  E-value: 2.88e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086  42 HCSGVNTLDIEPvEGRYMLSGGSDGVIVLYDLENasrqpyYTCKAVCsvgRSHPDvhkySVETVQWyPHDTGMFTSSSFD 121
Cdd:cd00200   92 HTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVET------GKCLTTL---RGHTD----WVNSVAF-SPDGTFVASSSQD 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086 122 KTLKVWDTNTLQAADVFN-FEETVYSHHMSPAATKHClvaVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRyDY 200
Cdd:cd00200  157 GTIKLWDLRTGKCVATLTgHTGEVNSVAFSPDGEKLL---SSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD-GY 232

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 402766086 201 ILATASADSRVKLWDVRRASgCLLTLdqhngkksqavesanTAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 273
Cdd:cd00200  233 LLASGSEDGTIRVWDLRTGE-CVQTL---------------SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
42-273 3.17e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.54  E-value: 3.17e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086  42 HCSGVNTLDIEPvEGRYMLSGGSDGVIVLYDLenASRQPYYTCKAvcsvgrshpdvHKYSVETVQWYPhDTGMFTSSSFD 121
Cdd:COG2319  161 HSGAVTSVAFSP-DGKLLASGSDDGTVRLWDL--ATGKLLRTLTG-----------HTGAVRSVAFSP-DGKLLASGSAD 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086 122 KTLKVWDTNTLQAADVFNFEE-TVYSHHMSPAATkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRyDY 200
Cdd:COG2319  226 GTVRLWDLATGKLLRTLTGHSgSVRSVAFSPDGR---LLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPD-GK 301

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086 201 ILATASADSRVKLWDVrrASG-CLLTLDQHNGKKSQAVESAN---------------------------TAHNGKVNGLC 252
Cdd:COG2319  302 LLASGSDDGTVRLWDL--ATGkLLRTLTGHTGAVRSVAFSPDgktlasgsddgtvrlwdlatgellrtlTGHTGAVTSVA 379

                        250       260
                 ....*....|....*....|.
gi 402766086 253 FTSDGLHLLTVGTDNRMRLWN 273
Cdd:COG2319  380 FSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
98-369 2.81e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.45  E-value: 2.81e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086  98 HKYSVETVQWYPHDTGMFTSSSFDKTLKVWDTNTLQAADVFNFEETVYSHHMSPAATkhcLVAVGTRGPKVQLCDLKSGS 177
Cdd:COG2319   35 LAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGR---LLASASADGTVRLWDLATGL 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086 178 CSHILQGHRQEILAVSWSPryD-YILATASADSRVKLWDVrrASG-CLLTLdqhngkksqavesanTAHNGKVNGLCFTS 255
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFSP--DgKTLASGSADGTVRLWDL--ATGkLLRTL---------------TGHSGAVTSVAFSP 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086 256 DGLHLLTVGTDNRMRLWNSSSGD--NTLVNYGKVCNS---SRKGlKFTVSHGcnsefvfvpYDSTIAMYAVYSGERLAML 330
Cdd:COG2319  173 DGKLLASGSDDGTVRLWDLATGKllRTLTGHTGAVRSvafSPDG-KLLASGS---------ADGTVRLWDLATGKLLRTL 242

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 402766086 331 KGHYKSVDCCVFQPNFQELYSGSRDCNILAWVPASYEPV 369
Cdd:COG2319  243 TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELL 281
WD40 COG2319
WD40 repeat [General function prediction only];
42-217 1.47e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.50  E-value: 1.47e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086  42 HCSGVNTLDIEPvEGRYMLSGGSDGVIVLYDLENASRQPYYTckavcsvgrshpdVHKYSVETVQWYPhDTGMFTSSSFD 121
Cdd:COG2319  245 HSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLT-------------GHSGGVNSVAFSP-DGKLLASGSDD 309

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086 122 KTLKVWDTNTLQAADVFN-FEETVYSHHMSPAATkhcLVAVGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPRYDY 200
Cdd:COG2319  310 GTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGK---TLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRT 386

                        170
                 ....*....|....*..
gi 402766086 201 iLATASADSRVKLWDVR 217
Cdd:COG2319  387 -LASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 178-369 2.36e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.92  E-value: 2.36e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086 178 CSHILQGHRQEILAVSWSPRYDYiLATASADSRVKLWDVrrasgclltldqhngkKSQAVESANTAHNGKVNGLCFTSDG 257
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKL-LATGSGDGTIKVWDL----------------ETGELLRTLKGHTGPVRDVAASADG 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086 258 LHLLTVGTDNRMRLWNSSSGD--NTLVNYGKVCNSsrkgLKFTVSH----GCNSefvfvpyDSTIAMYAVYSGERLAMLK 331
Cdd:cd00200   64 TYLASGSSDKTIRLWDLETGEcvRTLTGHTSYVSS----VAFSPDGrilsSSSR-------DKTIKVWDVETGKCLTTLR 132

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 402766086 332 GHYKSVDCCVFQPNFQELYSGSRDCNILAWVPASYEPV 369
Cdd:cd00200  133 GHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCV 170
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 175-215 1.99e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 1.99e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 402766086   175 SGSCSHILQGHRQEILAVSWSPRYDYiLATASADSRVKLWD 215
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
176-215 5.05e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 5.05e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 402766086  176 GSCSHILQGHRQEILAVSWSPRYDYiLATASADSRVKLWD 215
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 172-281 4.40e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 45.71  E-value: 4.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086 172 DLKSGSCshILQGHRQEILAVSWSPRYDYILATASADSRVKLWDV---RRA----------------SGCLLTLDQHNGK 232
Cdd:PTZ00420 113 EIKDPQC--ILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIeneKRAfqinmpkklsslkwniKGNLLSGTCVGKH 190

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 402766086 233 ------KSQAVESANTAHNGKVNGLCFTSDGL-----HLLTVG-TDNRMR---LW---NSSSGDNTL 281
Cdd:PTZ00420 191 mhiidpRKQEIASSFHIHDGGKNTKNIWIDGLggddnYILSTGfSKNNMRemkLWdlkNTTSALVTM 257
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 82-279 5.12e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.46  E-value: 5.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086  82 YTCKAVCSVGRshpDVHKYSVE--------TVQWYPHDTGMFTSSSFDKTLKVWDTNTLQ-AADVFNFEETVYSHHMSPA 152
Cdd:PLN00181 510 FECESIIKDGR---DIHYPVVElasrsklsGICWNSYIKSQVASSNFEGVVQVWDVARSQlVTEMKEHEKRVWSIDYSSA 586

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086 153 ATKhcLVAVGTRGPKVQLCDLKSGSCSHILQGhRQEILAVSWSPRYDYILATASADSRVKLWDVRRASGCLLTLdqhngk 232
Cdd:PLN00181 587 DPT--LLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKLPLCTM------ 657

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 402766086 233 ksqavesanTAHNGKVNGLCFTsDGLHLLTVGTDNRMRLWN---SSSGDN 279
Cdd:PLN00181 658 ---------IGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDlsmSISGIN 697
PTZ00421 PTZ00421
coronin; Provisional
 173-278 1.11e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 44.11  E-value: 1.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086 173 LKSGSCSHI--LQGHRQEILAVSWSPRYDYILATASADSRVKLWDVRRasgclltldqhnGKKSQAVESantaHNGKVNG 250
Cdd:PTZ00421 110 LTQNISDPIvhLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVER------------GKAVEVIKC----HSDQITS 173

                         90       100
                 ....*....|....*....|....*...
gi 402766086 251 LCFTSDGLHLLTVGTDNRMRLWNSSSGD 278
Cdd:PTZ00421 174 LEWNLDGSLLCTTSKDKKLNIIDPRDGT 201
WD40 COG2319
WD40 repeat [General function prediction only];
42-131 1.51e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 43.75  E-value: 1.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086  42 HCSGVNTLDIEPvEGRYMLSGGSDGVIVLYDLenASRQPYYTCKAvcsvgrshpdvHKYSVETVQWYPhDTGMFTSSSFD 121
Cdd:COG2319  329 HTGAVRSVAFSP-DGKTLASGSDDGTVRLWDL--ATGELLRTLTG-----------HTGAVTSVAFSP-DGRTLASGSAD 393

                         90
                 ....*....|
gi 402766086 122 KTLKVWDTNT 131
Cdd:COG2319  394 GTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 242-273 3.43e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 3.43e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 402766086   242 TAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 273
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 323-361 5.62e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 5.62e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 402766086   323 SGERLAMLKGHYKSVDCCVFQPNFQELYSGSRDCNILAW 361
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
324-361 1.40e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 1.40e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 402766086  324 GERLAMLKGHYKSVDCCVFQPNFQELYSGSRDCNILAW 361
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
242-273 3.10e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 3.10e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 402766086  242 TAHNGKVNGLCFTSDGLHLLTVGTDNRMRLWN 273
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 192-278 5.40e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 35.72  E-value: 5.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402766086  192 VSWSPRYDyILATASADSRVklwDVRRASGclltldqhngkksQAVESANT-AHNGKVNGLCFTSDGlHLLTVGT-DNRM 269
Cdd:pfam12894   1 MSWCPTMD-LIALATEDGEL---LLHRLNW-------------QRVWTLSPdKEDLEVTSLAWRPDG-KLLAVGYsDGTV 62


                  ....*....
gi 402766086  270 RLWNSSSGD 278
Cdd:pfam12894  63 RLLDAENGK 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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