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Conserved domains on  [gi|157817558|ref|NP_001100861|]
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janus kinase and microtubule-interacting protein 2 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
JAKMIP_CC3 pfam16034
JAKMIP CC3 domain; This domain is found at the C-terminus of proteins belonging to the JAKMIP ...
409-602 1.12e-71

JAKMIP CC3 domain; This domain is found at the C-terminus of proteins belonging to the JAKMIP family (Janus kinase and microtubule-interacting proteins) and is predicted to be a coiled coil. It interacts with the Janus family kinases Tyk2 and Jak1.


:

Pssm-ID: 464986 [Multi-domain]  Cd Length: 199  Bit Score: 234.00  E-value: 1.12e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558  409 DREKLIRRRKHRRSSKPIKRP--VLDPFIGYDED-SMDSETSSMtSFRTDR---TPATPDDDLDESLAAEESELRFRQLT 482
Cdd:pfam16034   1 ERDKLIRARKQRRKEKKKKLRdmVVETFFGYDEEaSVDSETSSL-SYNTDRtdsTPATPDEDLDEGVAAEEAELRFRQLT 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558  483 KEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYRAKIEDLEATLAQKGQDSHWVEDKQLFIKRNQELLEKIEK 562
Cdd:pfam16034  80 REYQALQRAYALLQEQSGGTLDAEREAKTREQLQAELRRAQSRIEDLESALAQKGQDSKWVEEKQALIRRNQELVEKIRI 159
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 157817558  563 QEAENHRLQQELQDARDQNELLEFRNLELEERERRSPPFN 602
Cdd:pfam16034 160 MEQEEGRLKNEIQDARDQNELLEFRILELEERERRSPAIN 199
Smc super family cl34174
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
19-600 9.48e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG1196:

Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 59.18  E-value: 9.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558  19 LQAANEDLrTKLTDIQIELhqeKSKVSKLEREKTQ--------EAKRIRELEQRKHTVLVTELKAKLHEEKMKELQAVRE 90
Cdd:COG1196  181 LEATEENL-ERLEDILGEL---ERQLEPLERQAEKaeryrelkEELKELEAELLLLKLRELEAELEELEAELEELEAELE 256
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558  91 NLIKQH---EQEMSRTVKVRDGEIQRLKSALCALRDGSSDKVRTALTIEAREEARKQFDAERLKLLQEITDLKTAKKQVD 167
Cdd:COG1196  257 ELEAELaelEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELE 336
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558 168 EALSNMIQADKIKAGDLRSEHQSHQEAISKIKwESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQKEALDEQ 247
Cdd:COG1196  337 EELEELEEELEEAEEELEEAEAELAEAEEALL-EAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLER 415
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558 248 LFLVKEAEcnmsspkreipgragdgsehcsspdlRRNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLL 327
Cdd:COG1196  416 LERLEEEL--------------------------EELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELL 469
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558 328 ERNKCLAKRNDELMVSLQRMEEKLKAITKENSEMREKITSHPPLKKLKSLNDLDQA-NEEQETEFLKLQVIE------QQ 400
Cdd:COG1196  470 EEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAvAVLIGVEAAYEAALEaalaaaLQ 549
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558 401 NIIDELTRDREKLIRRRKHR-------------RSSKPIKRPVLDPFIGYDEDSMDSETSSMTSFRTDRTpatpDDDLDE 467
Cdd:COG1196  550 NIVVEDDEVAAAAIEYLKAAkagratflpldkiRARAALAAALARGAIGAAVDLVASDLREADARYYVLG----DTLLGR 625
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558 468 SLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYRAKIEDLEATLAQKGQDSHWVEDKQ 547
Cdd:COG1196  626 TLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEE 705
                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|...
gi 157817558 548 LFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERERRSPP 600
Cdd:COG1196  706 ERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPE 758
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
478-804 2.43e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.58  E-value: 2.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   478 FRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQaevlRYRAKIEDLEATLaqkgqdshWVEDKQLFIKRNQELL 557
Cdd:TIGR02168  178 ERKLERTRENLDRLEDILNELERQLKSLERQAEKAERYK----ELKAELRELELAL--------LVLRLEELREELEELQ 245
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   558 EKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERerrsppFNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLD 637
Cdd:TIGR02168  246 EELKEAEEELEELTAELQELEEKLEELRLEVSELEEE------IEELQKELYALANEISRLEQQKQILRERLANLERQLE 319
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   638 ILgdNGNLRNEEQVAIIQASTVLSLAEKwIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQ 717
Cdd:TIGR02168  320 EL--EAQLEELESKLDELAEELAELEEK-LEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIA 396
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   718 ELEATLYNALQQETVIkfgellsDKQQEELRTAVEKLRRQMLRKSREYDCQILQERMELLQQAHQRIRDLEDKTDIQKRQ 797
Cdd:TIGR02168  397 SLNNEIERLEARLERL-------EDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREE 469

                   ....*..
gi 157817558   798 IKDLEEK 804
Cdd:TIGR02168  470 LEEAEQA 476
 
Name Accession Description Interval E-value
JAKMIP_CC3 pfam16034
JAKMIP CC3 domain; This domain is found at the C-terminus of proteins belonging to the JAKMIP ...
409-602 1.12e-71

JAKMIP CC3 domain; This domain is found at the C-terminus of proteins belonging to the JAKMIP family (Janus kinase and microtubule-interacting proteins) and is predicted to be a coiled coil. It interacts with the Janus family kinases Tyk2 and Jak1.


Pssm-ID: 464986 [Multi-domain]  Cd Length: 199  Bit Score: 234.00  E-value: 1.12e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558  409 DREKLIRRRKHRRSSKPIKRP--VLDPFIGYDED-SMDSETSSMtSFRTDR---TPATPDDDLDESLAAEESELRFRQLT 482
Cdd:pfam16034   1 ERDKLIRARKQRRKEKKKKLRdmVVETFFGYDEEaSVDSETSSL-SYNTDRtdsTPATPDEDLDEGVAAEEAELRFRQLT 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558  483 KEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYRAKIEDLEATLAQKGQDSHWVEDKQLFIKRNQELLEKIEK 562
Cdd:pfam16034  80 REYQALQRAYALLQEQSGGTLDAEREAKTREQLQAELRRAQSRIEDLESALAQKGQDSKWVEEKQALIRRNQELVEKIRI 159
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 157817558  563 QEAENHRLQQELQDARDQNELLEFRNLELEERERRSPPFN 602
Cdd:pfam16034 160 MEQEEGRLKNEIQDARDQNELLEFRILELEERERRSPAIN 199
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
19-600 9.48e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 59.18  E-value: 9.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558  19 LQAANEDLrTKLTDIQIELhqeKSKVSKLEREKTQ--------EAKRIRELEQRKHTVLVTELKAKLHEEKMKELQAVRE 90
Cdd:COG1196  181 LEATEENL-ERLEDILGEL---ERQLEPLERQAEKaeryrelkEELKELEAELLLLKLRELEAELEELEAELEELEAELE 256
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558  91 NLIKQH---EQEMSRTVKVRDGEIQRLKSALCALRDGSSDKVRTALTIEAREEARKQFDAERLKLLQEITDLKTAKKQVD 167
Cdd:COG1196  257 ELEAELaelEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELE 336
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558 168 EALSNMIQADKIKAGDLRSEHQSHQEAISKIKwESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQKEALDEQ 247
Cdd:COG1196  337 EELEELEEELEEAEEELEEAEAELAEAEEALL-EAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLER 415
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558 248 LFLVKEAEcnmsspkreipgragdgsehcsspdlRRNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLL 327
Cdd:COG1196  416 LERLEEEL--------------------------EELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELL 469
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558 328 ERNKCLAKRNDELMVSLQRMEEKLKAITKENSEMREKITSHPPLKKLKSLNDLDQA-NEEQETEFLKLQVIE------QQ 400
Cdd:COG1196  470 EEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAvAVLIGVEAAYEAALEaalaaaLQ 549
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558 401 NIIDELTRDREKLIRRRKHR-------------RSSKPIKRPVLDPFIGYDEDSMDSETSSMTSFRTDRTpatpDDDLDE 467
Cdd:COG1196  550 NIVVEDDEVAAAAIEYLKAAkagratflpldkiRARAALAAALARGAIGAAVDLVASDLREADARYYVLG----DTLLGR 625
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558 468 SLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYRAKIEDLEATLAQKGQDSHWVEDKQ 547
Cdd:COG1196  626 TLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEE 705
                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|...
gi 157817558 548 LFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERERRSPP 600
Cdd:COG1196  706 ERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPE 758
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
19-804 1.70e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 55.06  E-value: 1.70e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558    19 LQAANEDLrTKLTDIQIELhqeKSKVSKLER--EKTQEAKRIR-ELEQRKHTVLVTELKAklHEEKMKELQAVRENLIKQ 95
Cdd:TIGR02168  181 LERTRENL-DRLEDILNEL---ERQLKSLERqaEKAERYKELKaELRELELALLVLRLEE--LREELEELQEELKEAEEE 254
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558    96 HEqEMSRTVKVRDGEIQRLKSAlcalrdgssdkvrtaltIEAREEARKQFDAERLKLLQEITDLKTAKKQVDEALSNMiQ 175
Cdd:TIGR02168  255 LE-ELTAELQELEEKLEELRLE-----------------VSELEEEIEELQKELYALANEISRLEQQKQILRERLANL-E 315
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   176 ADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKakdriifSLEKELETQTGYVQKLQLQKEALDEQLflvKEAE 255
Cdd:TIGR02168  316 RQLEELEAQLEELESKLDELAEELAELEEKLEELKEELE-------SLEAELEELEAELEELESRLEELEEQL---ETLR 385
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   256 CNMSSPKREIpgragdgsehcsspdlRRNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKqcKPLLERNKCLAK 335
Cdd:TIGR02168  386 SKVAQLELQI----------------ASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAEL--KELQAELEELEE 447
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   336 RNDELMVSLQRMEEKLKAITKENSEMREKITS-----HPPLKKLKSLNDLdQANEEQETEFLKLQVIEQQNIIDELTRDR 410
Cdd:TIGR02168  448 ELEELQEELERLEEALEELREELEEAEQALDAaerelAQLQARLDSLERL-QENLEGFSEGVKALLKNQSGLSGILGVLS 526
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   411 EKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMTSFRTDR---------TPATPDDDLDESLAAEESELRFRQL 481
Cdd:TIGR02168  527 ELISVDEGYEAAIEAALGGRLQAVVVENLNAAKKAIAFLKQNELGRvtflpldsiKGTEIQGNDREILKNIEGFLGVAKD 606
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   482 TKEYQAlqRAYALLQEQTGGIIDAEREAKAQEQLQAevLRYRAKIEDLEATLAQKG----QDSHWVEDKQLFIKRN-QEL 556
Cdd:TIGR02168  607 LVKFDP--KLRKALSYLLGGVLVVDDLDNALELAKK--LRPGYRIVTLDGDLVRPGgvitGGSAKTNSSILERRREiEEL 682
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   557 LEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERERRSppfnlqihpfSDGVSALQIYCMKEGVKDVNIPDLIKQL 636
Cdd:TIGR02168  683 EEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEEL----------SRQISALRKDLARLEAEVEQLEERIAQL 752
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   637 DI-LGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMR 715
Cdd:TIGR02168  753 SKeLTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERR 832
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   716 IQELEATLYNALQQETVIKFGELLSDKQQEELRTAVEKLRRQMLRKSREYDCQI--LQERMELLQQAHQRIRDLEDKTDI 793
Cdd:TIGR02168  833 IAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEeaLALLRSELEELSEELRELESKRSE 912
                          810
                   ....*....|.
gi 157817558   794 QKRQIKDLEEK 804
Cdd:TIGR02168  913 LRRELEELREK 923
PTZ00121 PTZ00121
MAEBL; Provisional
24-217 1.14e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 46.29  E-value: 1.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   24 EDLRTKLTDIQIElHQEKSKVSKLEREKTQEAKRIREL--EQRKHTVLVTELKAKLHEEKMK--ELQAVRENLIKQHEQE 99
Cdd:PTZ00121 1616 EEAKIKAEELKKA-EEEKKKVEQLKKKEAEEKKKAEELkkAEEENKIKAAEEAKKAEEDKKKaeEAKKAEEDEKKAAEAL 1694
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558  100 MSRTVKVRDGEiqrlksalcALRDGSSDKVRTALTIEAREEARKqFDAERLKLLQEITDLKTAKKQVDEALSNMIQADKI 179
Cdd:PTZ00121 1695 KKEAEEAKKAE---------ELKKKEAEEKKKAEELKKAEEENK-IKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKK 1764
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 157817558  180 KAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKD 217
Cdd:PTZ00121 1765 EEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKD 1802
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
478-804 2.43e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.58  E-value: 2.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   478 FRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQaevlRYRAKIEDLEATLaqkgqdshWVEDKQLFIKRNQELL 557
Cdd:TIGR02168  178 ERKLERTRENLDRLEDILNELERQLKSLERQAEKAERYK----ELKAELRELELAL--------LVLRLEELREELEELQ 245
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   558 EKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERerrsppFNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLD 637
Cdd:TIGR02168  246 EELKEAEEELEELTAELQELEEKLEELRLEVSELEEE------IEELQKELYALANEISRLEQQKQILRERLANLERQLE 319
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   638 ILgdNGNLRNEEQVAIIQASTVLSLAEKwIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQ 717
Cdd:TIGR02168  320 EL--EAQLEELESKLDELAEELAELEEK-LEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIA 396
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   718 ELEATLYNALQQETVIkfgellsDKQQEELRTAVEKLRRQMLRKSREYDCQILQERMELLQQAHQRIRDLEDKTDIQKRQ 797
Cdd:TIGR02168  397 SLNNEIERLEARLERL-------EDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREE 469

                   ....*..
gi 157817558   798 IKDLEEK 804
Cdd:TIGR02168  470 LEEAEQA 476
hsdR PRK11448
type I restriction enzyme EcoKI subunit R; Provisional
458-577 4.03e-03

type I restriction enzyme EcoKI subunit R; Provisional


Pssm-ID: 236912 [Multi-domain]  Cd Length: 1123  Bit Score: 41.09  E-value: 4.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558  458 PATPDDDLDESLAAEESELRfRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLryrakiEDLEATLAQKG 537
Cdd:PRK11448  136 PPEDPENLLHALQQEVLTLK-QQLELQAREKAQSQALAEAQQQELVALEGLAAELEEKQQELE------AQLEQLQEKAA 208
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 157817558  538 QDSHwvEDKQLFIKRNQELLEKIEKQEAENHRL-QQELQDA 577
Cdd:PRK11448  209 ETSQ--ERKQKRKEITDQAAKRLELSEEETRILiDQQLRKA 247
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
646-811 4.05e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.08  E-value: 4.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558 646 RNEEQVAIIQASTVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYN 725
Cdd:COG1196  262 LAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEE 341
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558 726 ALQQETVIKFGELLSDKQQEELRTAVEKLRRQMLRKSREYDcQILQERMELLQQAHQRIRDLEDKTDIQKRQIKDLEEKT 805
Cdd:COG1196  342 LEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELE-ELAEELLEALRAAAELAAQLEELEEAEEALLERLERLE 420

                 ....*.
gi 157817558 806 IQLSGA 811
Cdd:COG1196  421 EELEEL 426
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
34-247 9.06e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 39.72  E-value: 9.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   34 QIELHQEKSKVSKLER---EKTQEAKRIRELEQRKHTVLVTELKAKLHEEKMKELQAV-----RENLIKQHEQEMSRTVK 105
Cdd:pfam17380 326 QAEMDRQAAIYAEQERmamERERELERIRQEERKRELERIRQEEIAMEISRMRELERLqmerqQKNERVRQELEAARKVK 405
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558  106 VRDGEIQRLKSAlcalRDGSSDKVRtALTIEAREEARKQFDAERLKLLQEITDLKTAKKQVDEALSNMIQADKIKAGDLR 185
Cdd:pfam17380 406 ILEEERQRKIQQ----QKVEMEQIR-AEQEEARQREVRRLEEERAREMERVRLEEQERQQQVERLRQQEEERKRKKLELE 480
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157817558  186 SEHQSHQEAISKIKWESERDI---RRLMDEIKAKDRIifsLEKELETQTGYVQKLQLQKEALDEQ 247
Cdd:pfam17380 481 KEKRDRKRAEEQRRKILEKELeerKQAMIEEERKRKL---LEKEMEERQKAIYEEERRREAEEER 542
 
Name Accession Description Interval E-value
JAKMIP_CC3 pfam16034
JAKMIP CC3 domain; This domain is found at the C-terminus of proteins belonging to the JAKMIP ...
409-602 1.12e-71

JAKMIP CC3 domain; This domain is found at the C-terminus of proteins belonging to the JAKMIP family (Janus kinase and microtubule-interacting proteins) and is predicted to be a coiled coil. It interacts with the Janus family kinases Tyk2 and Jak1.


Pssm-ID: 464986 [Multi-domain]  Cd Length: 199  Bit Score: 234.00  E-value: 1.12e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558  409 DREKLIRRRKHRRSSKPIKRP--VLDPFIGYDED-SMDSETSSMtSFRTDR---TPATPDDDLDESLAAEESELRFRQLT 482
Cdd:pfam16034   1 ERDKLIRARKQRRKEKKKKLRdmVVETFFGYDEEaSVDSETSSL-SYNTDRtdsTPATPDEDLDEGVAAEEAELRFRQLT 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558  483 KEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYRAKIEDLEATLAQKGQDSHWVEDKQLFIKRNQELLEKIEK 562
Cdd:pfam16034  80 REYQALQRAYALLQEQSGGTLDAEREAKTREQLQAELRRAQSRIEDLESALAQKGQDSKWVEEKQALIRRNQELVEKIRI 159
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 157817558  563 QEAENHRLQQELQDARDQNELLEFRNLELEERERRSPPFN 602
Cdd:pfam16034 160 MEQEEGRLKNEIQDARDQNELLEFRILELEERERRSPAIN 199
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
19-600 9.48e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 59.18  E-value: 9.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558  19 LQAANEDLrTKLTDIQIELhqeKSKVSKLEREKTQ--------EAKRIRELEQRKHTVLVTELKAKLHEEKMKELQAVRE 90
Cdd:COG1196  181 LEATEENL-ERLEDILGEL---ERQLEPLERQAEKaeryrelkEELKELEAELLLLKLRELEAELEELEAELEELEAELE 256
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558  91 NLIKQH---EQEMSRTVKVRDGEIQRLKSALCALRDGSSDKVRTALTIEAREEARKQFDAERLKLLQEITDLKTAKKQVD 167
Cdd:COG1196  257 ELEAELaelEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELE 336
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558 168 EALSNMIQADKIKAGDLRSEHQSHQEAISKIKwESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQKEALDEQ 247
Cdd:COG1196  337 EELEELEEELEEAEEELEEAEAELAEAEEALL-EAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLER 415
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558 248 LFLVKEAEcnmsspkreipgragdgsehcsspdlRRNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLL 327
Cdd:COG1196  416 LERLEEEL--------------------------EELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELL 469
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558 328 ERNKCLAKRNDELMVSLQRMEEKLKAITKENSEMREKITSHPPLKKLKSLNDLDQA-NEEQETEFLKLQVIE------QQ 400
Cdd:COG1196  470 EEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAvAVLIGVEAAYEAALEaalaaaLQ 549
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558 401 NIIDELTRDREKLIRRRKHR-------------RSSKPIKRPVLDPFIGYDEDSMDSETSSMTSFRTDRTpatpDDDLDE 467
Cdd:COG1196  550 NIVVEDDEVAAAAIEYLKAAkagratflpldkiRARAALAAALARGAIGAAVDLVASDLREADARYYVLG----DTLLGR 625
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558 468 SLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYRAKIEDLEATLAQKGQDSHWVEDKQ 547
Cdd:COG1196  626 TLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEE 705
                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|...
gi 157817558 548 LFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERERRSPP 600
Cdd:COG1196  706 ERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPE 758
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
19-804 1.70e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 55.06  E-value: 1.70e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558    19 LQAANEDLrTKLTDIQIELhqeKSKVSKLER--EKTQEAKRIR-ELEQRKHTVLVTELKAklHEEKMKELQAVRENLIKQ 95
Cdd:TIGR02168  181 LERTRENL-DRLEDILNEL---ERQLKSLERqaEKAERYKELKaELRELELALLVLRLEE--LREELEELQEELKEAEEE 254
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558    96 HEqEMSRTVKVRDGEIQRLKSAlcalrdgssdkvrtaltIEAREEARKQFDAERLKLLQEITDLKTAKKQVDEALSNMiQ 175
Cdd:TIGR02168  255 LE-ELTAELQELEEKLEELRLE-----------------VSELEEEIEELQKELYALANEISRLEQQKQILRERLANL-E 315
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   176 ADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKakdriifSLEKELETQTGYVQKLQLQKEALDEQLflvKEAE 255
Cdd:TIGR02168  316 RQLEELEAQLEELESKLDELAEELAELEEKLEELKEELE-------SLEAELEELEAELEELESRLEELEEQL---ETLR 385
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   256 CNMSSPKREIpgragdgsehcsspdlRRNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKqcKPLLERNKCLAK 335
Cdd:TIGR02168  386 SKVAQLELQI----------------ASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAEL--KELQAELEELEE 447
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   336 RNDELMVSLQRMEEKLKAITKENSEMREKITS-----HPPLKKLKSLNDLdQANEEQETEFLKLQVIEQQNIIDELTRDR 410
Cdd:TIGR02168  448 ELEELQEELERLEEALEELREELEEAEQALDAaerelAQLQARLDSLERL-QENLEGFSEGVKALLKNQSGLSGILGVLS 526
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   411 EKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMTSFRTDR---------TPATPDDDLDESLAAEESELRFRQL 481
Cdd:TIGR02168  527 ELISVDEGYEAAIEAALGGRLQAVVVENLNAAKKAIAFLKQNELGRvtflpldsiKGTEIQGNDREILKNIEGFLGVAKD 606
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   482 TKEYQAlqRAYALLQEQTGGIIDAEREAKAQEQLQAevLRYRAKIEDLEATLAQKG----QDSHWVEDKQLFIKRN-QEL 556
Cdd:TIGR02168  607 LVKFDP--KLRKALSYLLGGVLVVDDLDNALELAKK--LRPGYRIVTLDGDLVRPGgvitGGSAKTNSSILERRREiEEL 682
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   557 LEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERERRSppfnlqihpfSDGVSALQIYCMKEGVKDVNIPDLIKQL 636
Cdd:TIGR02168  683 EEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEEL----------SRQISALRKDLARLEAEVEQLEERIAQL 752
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   637 DI-LGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMR 715
Cdd:TIGR02168  753 SKeLTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERR 832
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   716 IQELEATLYNALQQETVIKFGELLSDKQQEELRTAVEKLRRQMLRKSREYDCQI--LQERMELLQQAHQRIRDLEDKTDI 793
Cdd:TIGR02168  833 IAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEeaLALLRSELEELSEELRELESKRSE 912
                          810
                   ....*....|.
gi 157817558   794 QKRQIKDLEEK 804
Cdd:TIGR02168  913 LRRELEELREK 923
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
13-248 4.41e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 53.79  E-value: 4.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558  13 EALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQRKHTVLVTELKAKLHEEKMKELQAVRENL 92
Cdd:COG1196  266 EAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEE 345
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558  93 IKQHEQEMSRTVKVRDGEIQRLKSALCALRDGSSDKVRTALTIEAREEARKQFDAERLKLLQEITDLKTAKKQVDEALSN 172
Cdd:COG1196  346 LEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEE 425
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 157817558 173 mIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQKEALDEQL 248
Cdd:COG1196  426 -LEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAE 500
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
13-340 6.10e-07

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 53.53  E-value: 6.10e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558    13 EALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQRKhtvlvTELKAKLhEEKMKELQAVRENL 92
Cdd:TIGR02169  701 ENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEI-----ENVKSEL-KELEARIEELEEDL 774
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558    93 IKQHEQEMSRTVKVRDGEIQRLKSALCALRDGSSDKVRTALTIEAREEAR----KQFDAERLKLLQEITDLKTAKKQVDE 168
Cdd:TIGR02169  775 HKLEEALNDLEARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLtlekEYLEKEIQELQEQRIDLKEQIKSIEK 854
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   169 AlsnmIQADKIKAGDLRSEHQSHQEAI---SKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQKEALD 245
Cdd:TIGR02169  855 E----IENLNGKKEELEEELEELEAALrdlESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALE 930
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   246 EQLFLVKEAECNMSSPKREIPgragdgsehcsspDLRRNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKP 325
Cdd:TIGR02169  931 EELSEIEDPKGEDEEIPEEEL-------------SLEDVQAELQRVEEEIRALEPVNMLAIQEYEEVLKRLDELKEKRAK 997
                          330
                   ....*....|....*
gi 157817558   326 LLERNKCLAKRNDEL 340
Cdd:TIGR02169  998 LEEERKAILERIEEY 1012
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
3-804 8.01e-07

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 53.15  E-value: 8.01e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558     3 KKGRNKGEKPEALIVALQAANEDLRTK-LTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQRKHTVLVT--ELKAKLHE 79
Cdd:TIGR02169  204 RREREKAERYQALLKEKREYEGYELLKeKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLleELNKKIKD 283
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558    80 EKMKELQAVRENlIKQHEQEMSRTVKVRDGEIQRLKSALCALRDGSSDKVRTALTIEAREEARKQFDAERLKLLQEITDL 159
Cdd:TIGR02169  284 LGEEEQLRVKEK-IGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAEL 362
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   160 KtakkQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWE---SERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQK 236
Cdd:TIGR02169  363 K----EELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREineLKRELDRLQEELQRLSEELADLNAAIAGIEAKINE 438
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   237 LQLQKEALDEQlflVKEAECNMSSPKReipgragdgsehcsspDLRRNQKRIAELNATIRKLEDRNTLLGDERNELLKRV 316
Cdd:TIGR02169  439 LEEEKEDKALE---IKKQEWKLEQLAA----------------DLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQA 499
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   317 RETEKQCKPLLERNKCLAKRNDE---LMVSLQRMEEKLKAITKENSEMRekitshpplkkLKSLNDLDQANEEQETEFLK 393
Cdd:TIGR02169  500 RASEERVRGGRAVEEVLKASIQGvhgTVAQLGSVGERYATAIEVAAGNR-----------LNNVVVEDDAVAKEAIELLK 568
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   394 lqvieqqniidELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMTSFRTdrtpATPDDDLDESL-AAE 472
Cdd:TIGR02169  569 -----------RRKAGRATFLPLNKMRDERRDLSILSEDGVIGFAVDLVEFDPKYEPAFKY----VFGDTLVVEDIeAAR 633
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   473 ESELRFRQLTKEYQALQRAYALlqeqTGGIIDAEREAKAQEQLQAEVLRYRAKIEDLEATLAqkgqdshwvedkqlfikr 552
Cdd:TIGR02169  634 RLMGKYRMVTLEGELFEKSGAM----TGGSRAPRGGILFSRSEPAELQRLRERLEGLKRELS------------------ 691
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   553 nqELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERERRsppFNLQIHPFSDGVSALQ--IYCMKEGVKDVN-- 628
Cdd:TIGR02169  692 --SLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEK---LKERLEELEEDLSSLEqeIENVKSELKELEar 766
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   629 IPDLIKQL----DILGDNGNLRNEEQVAIIQAS-----TVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLE 699
Cdd:TIGR02169  767 IEELEEDLhkleEALNDLEARLSHSRIPEIQAElskleEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLK 846
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   700 EELDYRKQALDQAYMRIQELEATLynalqqetvikfgellsdkqqEELRTAVEKLRRQMLRKSREYDcqilqERMELLQQ 779
Cdd:TIGR02169  847 EQIKSIEKEIENLNGKKEELEEEL---------------------EELEAALRDLESRLGDLKKERD-----ELEAQLRE 900
                          810       820
                   ....*....|....*....|....*
gi 157817558   780 AHQRIRDLEDKTDIQKRQIKDLEEK 804
Cdd:TIGR02169  901 LERKIEELEAQIEKKRKRLSELKAK 925
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
13-248 9.83e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 49.67  E-value: 9.83e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558    13 EALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQRKHTVLV----TELKAKLHEEKMKELQAV 88
Cdd:TIGR02168  711 EEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEErleeAEEELAEAEAEIEELEAQ 790
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558    89 RENLIKQHEQEMSRTVKVRDgEIQRLKSALCALRDG----SSDKVRTALTIEAREEARKQFDAERLKLLQEITDLKTAKK 164
Cdd:TIGR02168  791 IEQLKEELKALREALDELRA-ELTLLNEEAANLRERleslERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIE 869
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   165 QvdealsnmIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQKEAL 244
Cdd:TIGR02168  870 E--------LESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNL 941

                   ....
gi 157817558   245 DEQL 248
Cdd:TIGR02168  942 QERL 945
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
17-248 1.57e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.22  E-value: 1.57e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558  17 VALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQRkhtVLVTELKAKLHEEKMKELQAVRENLIKQh 96
Cdd:COG4942   16 AAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERR---IAALARRIRALEQELAALEAELAELEKE- 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558  97 EQEMSRTVKVRDGEIQRLKSALCalRDGSSDKVRTALTIEAREEArkqfdAERLKLLQEITdlktakkQVDEALSNMIQA 176
Cdd:COG4942   92 IAELRAELEAQKEELAELLRALY--RLGRQPPLALLLSPEDFLDA-----VRRLQYLKYLA-------PARREQAEELRA 157
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157817558 177 DKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQKEALDEQL 248
Cdd:COG4942  158 DLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALI 229
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
23-414 3.33e-05

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 47.74  E-value: 3.33e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558    23 NEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQRKHTVLVTELKAKLHEEKMKELQAVRENLiKQHEQEMSR 102
Cdd:TIGR01612  691 NTEDKAKLDDLKSKIDKEYDKIQNMETATVELHLSNIENKKNELLDIIVEIKKHIHGEINKDLNKILEDF-KNKEKELSN 769
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   103 TV----KVRDgEIQRLKSALCALRDGSSDKVRTALTIEarEEARKQFDAERL----------KLLQEITDLKTAKKQVDE 168
Cdd:TIGR01612  770 KIndyaKEKD-ELNKYKSKISEIKNHYNDQINIDNIKD--EDAKQNYDKSKEyiktisikedEIFKIINEMKFMKDDFLN 846
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   169 ALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDI-----RRLMDEIKAKDRIIFSLEKE------LETQTGYVQKL 237
Cdd:TIGR01612  847 KVDKFINFENNCKEKIDSEHEQFAELTNKIKAEISDDKlndyeKKFNDSKSLINEINKSIEEEyqnintLKKVDEYIKIC 926
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   238 QLQKEALDEqlFLVKEAECNmsspkrEIpgragdgsehcsspdLRRNQKRIAELNATIRKLEDR--NTLLgDERNELLKR 315
Cdd:TIGR01612  927 ENTKESIEK--FHNKQNILK------EI---------------LNKNIDTIKESNLIEKSYKDKfdNTLI-DKINELDKA 982
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   316 VREtekqckplLERNKCLAKrNDELMVSLQRMEEKLkaitkenSEMREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQ 395
Cdd:TIGR01612  983 FKD--------ASLNDYEAK-NNELIKYFNDLKANL-------GKNKENMLYHQFDEKEKATNDIEQKIEDANKNIPNIE 1046
                          410       420
                   ....*....|....*....|..
gi 157817558   396 VIEQQ---NIIDELtrdrEKLI 414
Cdd:TIGR01612 1047 IAIHTsiyNIIDEI----EKEI 1064
PTZ00121 PTZ00121
MAEBL; Provisional
24-217 1.14e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 46.29  E-value: 1.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   24 EDLRTKLTDIQIElHQEKSKVSKLEREKTQEAKRIREL--EQRKHTVLVTELKAKLHEEKMK--ELQAVRENLIKQHEQE 99
Cdd:PTZ00121 1616 EEAKIKAEELKKA-EEEKKKVEQLKKKEAEEKKKAEELkkAEEENKIKAAEEAKKAEEDKKKaeEAKKAEEDEKKAAEAL 1694
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558  100 MSRTVKVRDGEiqrlksalcALRDGSSDKVRTALTIEAREEARKqFDAERLKLLQEITDLKTAKKQVDEALSNMIQADKI 179
Cdd:PTZ00121 1695 KKEAEEAKKAE---------ELKKKEAEEKKKAEELKKAEEENK-IKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKK 1764
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 157817558  180 KAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKD 217
Cdd:PTZ00121 1765 EEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKD 1802
COG5022 COG5022
Myosin heavy chain [General function prediction only];
21-369 1.36e-04

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 45.84  E-value: 1.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   21 AANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQRKHTVLV-----TELKAKLH---------EEKMKEL- 85
Cdd:COG5022   734 AALEDMRDAKLDNIATRIQRAIRGRYLRRRYLQALKRIKKIQVIQHGFRLrrlvdYELKWRLFiklqpllslLGSRKEYr 813
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   86 QAVRENLIKQHEQEMSRTVKVRDGEIQRLKSALCALRDGSSDKVRTALTIEAREEARKQFDAERLKLLQEITDLKTAKKQ 165
Cdd:COG5022   814 SYLACIIKLQKTIKREKKLRETEEVEFSLKAEVLIQKFGRSLKAKKRFSLLKKETIYLQSAQRVELAERQLQELKIDVKS 893
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558  166 VDEALSNMIQADKiKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDriifSLEKELETQTgYVQKLQLQKEALD 245
Cdd:COG5022   894 ISSLKLVNLELES-EIIELKKSLSSDLIENLEFKTELIARLKKLLNNIDLEE----GPSIEYVKLP-ELNKLHEVESKLK 967
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558  246 EQLF----LVKE----------AECNMSSPKREIPG-RAGDGSEHCSSPDLRRNQKRIAELNATIRKLEDRNTLLG---- 306
Cdd:COG5022   968 ETSEeyedLLKKstilvregnkANSELKNFKKELAElSKQYGALQESTKQLKELPVEVAELQSASKIISSESTELSilkp 1047
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157817558  307 --DERNELLKRVRETEKQCKPLLERNKcLAKRNDELMVSLQRMEEKLKAITKENSEMREKITSHP 369
Cdd:COG5022  1048 lqKLKGLLLLENNQLQARYKALKLRRE-NSLLDDKQLYQLESTENLLKTINVKDLEVTNRNLVKP 1111
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
24-407 2.74e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 44.63  E-value: 2.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   24 EDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQRKHTVLvTELKAKlhEEKMKELQAVRENLIKQHEQEMSRT 103
Cdd:TIGR04523  99 NKLNSDLSKINSEIKNDKEQKNKLEVELNKLEKQKKENKKNIDKFL-TEIKKK--EKELEKLNNKYNDLKKQKEELENEL 175
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558  104 VKVRDgEIQRLKSALCALRDGSSDKVRTALTIEAREEARKqfdaerlKLLQEITDLKTAKKQvdeaLSNMIQADKIKAGD 183
Cdd:TIGR04523 176 NLLEK-EKLNIQKNIDKIKNKLLKLELLLSNLKKKIQKNK-------SLESQISELKKQNNQ----LKDNIEKKQQEINE 243
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558  184 LRSEHQSHQEAISKIKWESERDIRRLMD---EIKAKDRIIFSLEKELETQTGYVQKLQLQKEAldEQLFLVKEAECNMSS 260
Cdd:TIGR04523 244 KTTEISNTQTQLNQLKDEQNKIKKQLSEkqkELEQNNKKIKELEKQLNQLKSEISDLNNQKEQ--DWNKELKSELKNQEK 321
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558  261 PKREIpgragdgsehcsSPDLRRNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDEL 340
Cdd:TIGR04523 322 KLEEI------------QNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNL 389
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157817558  341 MVSLQRMEEKLKAITKENSEMREKItshpplKKLKSLNDLdqanEEQETEFLKLQVIEQQNIIDELT 407
Cdd:TIGR04523 390 ESQINDLESKIQNQEKLNQQKDEQI------KKLQQEKEL----LEKEIERLKETIIKNNSEIKDLT 446
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
36-373 4.26e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 44.29  E-value: 4.26e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558    36 ELHQEKSKVSKLEREKTQEAKRIRELEQRKH--TVLVTELKAKlHEEKMKELQAVRENLIKQHEQ--EMSRTVKVRDGEI 111
Cdd:TIGR02169  675 ELQRLRERLEGLKRELSSLQSELRRIENRLDelSQELSDASRK-IGEIEKEIEQLEQEEEKLKERleELEEDLSSLEQEI 753
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   112 QRLKSALCALRDGSSDKVRTALTIEAREEARKQFDAERL--KLLQEITDLKTAKKQVDEALSNMIQadkikagDLRSEHQ 189
Cdd:TIGR02169  754 ENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSRipEIQAELSKLEEEVSRIEARLREIEQ-------KLNRLTL 826
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   190 SHQEAISKIKwESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRA 269
Cdd:TIGR02169  827 EKEYLEKEIQ-ELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKI 905
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   270 GDGSEhcsspDLRRNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRET------EKQCKPLLERNKCLAKRN------ 337
Cdd:TIGR02169  906 EELEA-----QIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPEEElsledvQAELQRVEEEIRALEPVNmlaiqe 980
                          330       340       350
                   ....*....|....*....|....*....|....*..
gi 157817558   338 -DELMVSLQRMEEKLKAITKENSEMREKITSHPPLKK 373
Cdd:TIGR02169  981 yEEVLKRLDELKEKRAKLEEERKAILERIEEYEKKKR 1017
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
280-758 6.19e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.39  E-value: 6.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558 280 DLRRNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAITKENS 359
Cdd:COG1196  261 ELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELE 340
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558 360 EMREKitshppLKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIkrpvldpfIGYDE 439
Cdd:COG1196  341 ELEEE------LEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQ--------LEELE 406
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558 440 DSMDSETSSMTSFRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEV 519
Cdd:COG1196  407 EAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEEL 486
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558 520 LRYRAKIEDLEATLAQKGQDSHWVEDKQLFIKRN------QELLEKIEKQEAE---------NHRLQQELQDARDQNELL 584
Cdd:COG1196  487 AEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRglagavAVLIGVEAAYEAAleaalaaalQNIVVEDDEVAAAAIEYL 566
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558 585 EFRN------LELEERERRSPPFN----LQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQV--- 651
Cdd:COG1196  567 KAAKagratfLPLDKIRARAALAAalarGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAgrl 646
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558 652 ----------------AIIQASTVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMR 715
Cdd:COG1196  647 revtlegeggsaggslTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEAL 726
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|
gi 157817558 716 IQELEATLYNALQQETVIK-------FGELLSDKQQEELRTAVEKLRRQM 758
Cdd:COG1196  727 EEQLEAEREELLEELLEEEelleeeaLEELPEPPDLEELERELERLEREI 776
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
75-597 7.65e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.39  E-value: 7.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558  75 AKLHEEK---MKELQAVRENLI----------KQHE------------QEMSRTVKVRDGEIQRLKsalcaLRDGSSDKV 129
Cdd:COG1196  168 SKYKERKeeaERKLEATEENLErledilgeleRQLEplerqaekaeryRELKEELKELEAELLLLK-----LRELEAELE 242
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558 130 RTALTIEAREEARKQFDAERLKLLQEITDLKTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKwESERDIRRL 209
Cdd:COG1196  243 ELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRR-ELEERLEEL 321
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558 210 MDEIKAKDRIIFSLEKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSP--DLRRNQKR 287
Cdd:COG1196  322 EEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEAlrAAAELAAQ 401
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558 288 IAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAITKENSEMREKITS 367
Cdd:COG1196  402 LEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAE 481
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558 368 -HPPLKKLKSLNDLDQANEEQETEFL-----KLQVIEQQNIIDELTRDR-----EKLIRRRKHRRSSKPIKRPVLDPFIG 436
Cdd:COG1196  482 lLEELAEAAARLLLLLEAEADYEGFLegvkaALLLAGLRGLAGAVAVLIgveaaYEAALEAALAAALQNIVVEDDEVAAA 561
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558 437 YDEDSMDSETSSMTSFRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALqRAYALLQEQTGGIIDAEREAKAQEQLQ 516
Cdd:COG1196  562 AIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADA-RYYVLGDTLLGRTLVAARLEAALRRAV 640
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558 517 AEVLRYRAKIEDLEATLAQKGQDSHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERER 596
Cdd:COG1196  641 TLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEE 720

                 .
gi 157817558 597 R 597
Cdd:COG1196  721 L 721
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
135-391 9.23e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 43.12  E-value: 9.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   135 IEAREEARKQFDAERLKLLQEITDLKTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESER---------- 204
Cdd:TIGR02168  689 LEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTEleaeieelee 768
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   205 DIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHcsspdLRRN 284
Cdd:TIGR02168  769 RLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERR-----LEDL 843
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   285 QKRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAITKENSEMREK 364
Cdd:TIGR02168  844 EEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREK 923
                          250       260       270
                   ....*....|....*....|....*....|
gi 157817558   365 ITSHPPLK---KLKSLNDLDQANEEQETEF 391
Cdd:TIGR02168  924 LAQLELRLeglEVRIDNLQERLSEEYSLTL 953
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
13-253 2.05e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.97  E-value: 2.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558    13 EALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQRKHTVLVT---------ELKAKLH--EEK 81
Cdd:TIGR02168  266 EEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQleeleskldELAEELAelEEK 345
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558    82 MKELQAVRENLIKQHE------QEMSRTVKVRDGEIQRLKSALCALRDG----SSDKVRTALTIEAREEARKQFDAERLK 151
Cdd:TIGR02168  346 LEELKEELESLEAELEeleaelEELESRLEELEEQLETLRSKVAQLELQiaslNNEIERLEARLERLEDRRERLQQEIEE 425
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   152 LLQEITDLKTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQT 231
Cdd:TIGR02168  426 LLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFS 505
                          250       260
                   ....*....|....*....|..
gi 157817558   232 GYVQKLQLQKEALDEQLFLVKE 253
Cdd:TIGR02168  506 EGVKALLKNQSGLSGILGVLSE 527
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
478-804 2.43e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.58  E-value: 2.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   478 FRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQaevlRYRAKIEDLEATLaqkgqdshWVEDKQLFIKRNQELL 557
Cdd:TIGR02168  178 ERKLERTRENLDRLEDILNELERQLKSLERQAEKAERYK----ELKAELRELELAL--------LVLRLEELREELEELQ 245
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   558 EKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERerrsppFNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLD 637
Cdd:TIGR02168  246 EELKEAEEELEELTAELQELEEKLEELRLEVSELEEE------IEELQKELYALANEISRLEQQKQILRERLANLERQLE 319
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   638 ILgdNGNLRNEEQVAIIQASTVLSLAEKwIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQ 717
Cdd:TIGR02168  320 EL--EAQLEELESKLDELAEELAELEEK-LEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIA 396
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   718 ELEATLYNALQQETVIkfgellsDKQQEELRTAVEKLRRQMLRKSREYDCQILQERMELLQQAHQRIRDLEDKTDIQKRQ 797
Cdd:TIGR02168  397 SLNNEIERLEARLERL-------EDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREE 469

                   ....*..
gi 157817558   798 IKDLEEK 804
Cdd:TIGR02168  470 LEEAEQA 476
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
7-230 3.90e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.52  E-value: 3.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   7 NKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQRkhtvlVTELKAKLhEEKMKELQ 86
Cdd:COG4942   20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQE-----LAALEAEL-AELEKEIA 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558  87 AVRENLIKQHEQEMSRTVKV-RDGEIQRLKSALCAlrDGSSDKVRTALTIEAREEARKQFDAERLKLLQEITDLKTAKKQ 165
Cdd:COG4942   94 ELRAELEAQKEELAELLRALyRLGRQPPLALLLSP--EDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEA 171
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157817558 166 VDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWE---SERDIRRLMDEIKAKDRIIFSLEKELETQ 230
Cdd:COG4942  172 ERAELEALLAELEEERAALEALKAERQKLLARLEKElaeLAAELAELQQEAEELEALIARLEAEAAAA 239
hsdR PRK11448
type I restriction enzyme EcoKI subunit R; Provisional
458-577 4.03e-03

type I restriction enzyme EcoKI subunit R; Provisional


Pssm-ID: 236912 [Multi-domain]  Cd Length: 1123  Bit Score: 41.09  E-value: 4.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558  458 PATPDDDLDESLAAEESELRfRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLryrakiEDLEATLAQKG 537
Cdd:PRK11448  136 PPEDPENLLHALQQEVLTLK-QQLELQAREKAQSQALAEAQQQELVALEGLAAELEEKQQELE------AQLEQLQEKAA 208
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 157817558  538 QDSHwvEDKQLFIKRNQELLEKIEKQEAENHRL-QQELQDA 577
Cdd:PRK11448  209 ETSQ--ERKQKRKEITDQAAKRLELSEEETRILiDQQLRKA 247
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
646-811 4.05e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.08  E-value: 4.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558 646 RNEEQVAIIQASTVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYN 725
Cdd:COG1196  262 LAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEE 341
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558 726 ALQQETVIKFGELLSDKQQEELRTAVEKLRRQMLRKSREYDcQILQERMELLQQAHQRIRDLEDKTDIQKRQIKDLEEKT 805
Cdd:COG1196  342 LEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELE-ELAEELLEALRAAAELAAQLEELEEAEEALLERLERLE 420

                 ....*.
gi 157817558 806 IQLSGA 811
Cdd:COG1196  421 EELEEL 426
COG4026 COG4026
Uncharacterized conserved protein, contains TOPRIM domain, potential nuclease [General ...
308-364 7.83e-03

Uncharacterized conserved protein, contains TOPRIM domain, potential nuclease [General function prediction only];


Pssm-ID: 443204 [Multi-domain]  Cd Length: 287  Bit Score: 39.33  E-value: 7.83e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 157817558 308 ERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAITKENSEMREK 364
Cdd:COG4026  129 EYNELREELLELKEKIDEIAKEKEKLTKENEELESELEELREEYKKLREENSILEEE 185
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
34-247 9.06e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 39.72  E-value: 9.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558   34 QIELHQEKSKVSKLER---EKTQEAKRIRELEQRKHTVLVTELKAKLHEEKMKELQAV-----RENLIKQHEQEMSRTVK 105
Cdd:pfam17380 326 QAEMDRQAAIYAEQERmamERERELERIRQEERKRELERIRQEEIAMEISRMRELERLqmerqQKNERVRQELEAARKVK 405
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817558  106 VRDGEIQRLKSAlcalRDGSSDKVRtALTIEAREEARKQFDAERLKLLQEITDLKTAKKQVDEALSNMIQADKIKAGDLR 185
Cdd:pfam17380 406 ILEEERQRKIQQ----QKVEMEQIR-AEQEEARQREVRRLEEERAREMERVRLEEQERQQQVERLRQQEEERKRKKLELE 480
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157817558  186 SEHQSHQEAISKIKWESERDI---RRLMDEIKAKDRIifsLEKELETQTGYVQKLQLQKEALDEQ 247
Cdd:pfam17380 481 KEKRDRKRAEEQRRKILEKELeerKQAMIEEERKRKL---LEKEMEERQKAIYEEERRREAEEER 542
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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