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Conserved domains on  [gi|157820987|ref|NP_001100645|]
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protein phosphatase 1 regulatory subunit 15B [Rattus norvegicus]

Protein Classification

CReP_N and PP1c_bdg domain-containing protein( domain architecture ID 10564608)

CReP_N and PP1c_bdg domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CReP_N pfam10472
eIF2-alpha phosphatase phosphorylation constitutive repressor; This is the conserved ...
1-388 0e+00

eIF2-alpha phosphatase phosphorylation constitutive repressor; This is the conserved N-terminal domain of CReP, constitutive repressor of eIF2-alpha phosphorylation/protein phosphatase 1, catalytic subunit. It functions in the dephosphorylation of eIF2-alpha under basal conditions in the absence of stress. In response to translation inhibition, there is reduced synthesis of the labile CReP that contributes to elevated levels of eIF2-alpha phosphorylation. The C-terminus, family PP1c, is shared with the apoptosis-associated protein Gadd34 and herpes simplex virus.


:

Pssm-ID: 371074  Cd Length: 411  Bit Score: 594.10  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820987    1 METGTHRARKRPTSRMGSWFRLP--FLRRSHACTSEFPKPSSRPN-----LEVSARPEPRTRYWTKLLSQLLALLPSLLQ 73
Cdd:pfam10472   1 MEPGTDGSRKRPAPRAGSWFRLPffFPRRSQAGSSKFPTPPAPENsgdptLLSSAQPEARTSYWTKLLSQLLAPLPSLLQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820987   74 KLLIWSQLFGGMIPTRWLDFSASYSALRALRGREESAAPTVQKSLNSLRLDSSsEDLVVSSLDWLEEGLQGQCSSSDLEL 153
Cdd:pfam10472  81 KLLIWSQLFGGLIPTRWLDFAGGYSALRALRGREEPAAPTAQKSLSSLRLDPS-DDSVASPLDWLEEGIHWQCSSSDLEL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820987  154 KFKAQERALDSTAHTFLLEQQLWGVELLPGSLQTGLVSHRELGSSSSGPLSTQSLGNFKVVSYLLNPSYLDCLPQLELRC 233
Cdd:pfam10472 160 ELKAKGGALDPAAHAFLLEQQLWGVELLPSSLQAHLFSDRELGSSPSGPLNVQRLGNFNVVSYLLNPSYLDCLPRLELSC 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820987  234 QNSVGGGQLVDFRTLSPESCYLSEDACHPQPLCAEMSATAWRRCPPLSTEGLPEIHHLRMKRLEFL-QANKGQELPTPDQ 312
Cdd:pfam10472 240 QNSVGSGELVDFQTLTPESSCLSEDHCHPQPLNAEISAASWQGCPPLSREGLPEIHHLRMKRLEFLqQASKGQELPTPDQ 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820987  313 DNGYHSLEEEHCLLRMDPQHCTDKAAQAVSPAGASP----QPTEKKVELVVEEVL-----QSPQGSSLSCELSVQKECE- 382
Cdd:pfam10472 320 DNGYHSLEEEHSLLRMDLKHCRDNPTQCVPPAGAIPgtaqEPTEEKIELLTTEVPlalekQDPSGSCPSCEVPVEKEPGe 399
                         410
                  ....*....|..
gi 157820987  383 ------DYSDIG 388
Cdd:pfam10472 400 dqisvvDSSDIE 411
PP1c_bdg pfam10488
Phosphatase-1 catalytic subunit binding region; This conserved C-terminus appears to be a ...
391-673 6.96e-156

Phosphatase-1 catalytic subunit binding region; This conserved C-terminus appears to be a protein phosphatase-1 catalytic subunit (PP1C) binding region, which may in some circumstances also be retroviral in origin since it is found in both herpes simplex virus and in mouse and man. This domain is found in Gadd-34 apoptosis-associated proteins as well as the constitutive repressor of eIF2-alpha phosphorylation/protein phosphatase 1, regulatory (inhibitor) subunit 15b, otherwise known as CReP. Diverse stressful conditions are associated with phosphorylation of the {alpha} subunit of eukaryotic translation initiation factor 2 (eIF2{alpha}) on serine 51. This signaling event, which is conserved from yeast to mammals, negatively regulates the guanine nucleotide exchange factor, eIF2-B and inhibits the recycling of eIF2 to its active GTP bound form. In mammalian cells eIF2{alpha} phosphorylation emerges as an important event in stress signaling that impacts on gene expression at both the translational and transcriptional levels.


:

Pssm-ID: 431311  Cd Length: 287  Bit Score: 452.55  E-value: 6.96e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820987  391 LPVSTRPACTNKLIDYILGGASSDLDTSSDSESEDWDEEPEDDGFDSDGSLSESDREQDSEGLHLWNSFYSVDPYNPQNF 470
Cdd:pfam10488   1 LPISARPACSNKLIDYILGGASSDLETSSDSEGEDWDEEAEDDGFDSDGSLSESDKEQDSEGLHLWNSFYSVDPYNPQNF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820987  471 TATIQTAARIAPRDPSDSEKSWSGNSDVGS-SQATLLPQTPDQSSGEEDDWESSADEAENLRLWNSFCNSEDPYNLLNFK 549
Cdd:pfam10488  81 TATIQTAATIAPGDPSDSEKDLSDKSDLESvSQAESPPETPDHSSGEEDDWESSADEAESLKLWNSFCNSDDPYNPLNFR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820987  550 APFQTSGKSWKG---SQASSEATVVFSGHQTLLSCEAQLLESQEDNCPGCGLGEALSGERYTHIKRKKVTFLEEVTEYYI 626
Cdd:pfam10488 161 APFQTSGKNGKGcqdSKIPPESVVAISEGHALLSCKVQLLGSQERECPGLLQRGVLSGERHTSPKRKKVTFLEEVTEYYI 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 157820987  627 SGDEDRKGPWEEFARDGCRFQKRIQETEVAIGYCLTFEHRERVFSRL 673
Cdd:pfam10488 241 SGDEDRKGPWEEFARDGCRFQKRIQETEDAIGYCLTFEHREKMFNRL 287
 
Name Accession Description Interval E-value
CReP_N pfam10472
eIF2-alpha phosphatase phosphorylation constitutive repressor; This is the conserved ...
1-388 0e+00

eIF2-alpha phosphatase phosphorylation constitutive repressor; This is the conserved N-terminal domain of CReP, constitutive repressor of eIF2-alpha phosphorylation/protein phosphatase 1, catalytic subunit. It functions in the dephosphorylation of eIF2-alpha under basal conditions in the absence of stress. In response to translation inhibition, there is reduced synthesis of the labile CReP that contributes to elevated levels of eIF2-alpha phosphorylation. The C-terminus, family PP1c, is shared with the apoptosis-associated protein Gadd34 and herpes simplex virus.


Pssm-ID: 371074  Cd Length: 411  Bit Score: 594.10  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820987    1 METGTHRARKRPTSRMGSWFRLP--FLRRSHACTSEFPKPSSRPN-----LEVSARPEPRTRYWTKLLSQLLALLPSLLQ 73
Cdd:pfam10472   1 MEPGTDGSRKRPAPRAGSWFRLPffFPRRSQAGSSKFPTPPAPENsgdptLLSSAQPEARTSYWTKLLSQLLAPLPSLLQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820987   74 KLLIWSQLFGGMIPTRWLDFSASYSALRALRGREESAAPTVQKSLNSLRLDSSsEDLVVSSLDWLEEGLQGQCSSSDLEL 153
Cdd:pfam10472  81 KLLIWSQLFGGLIPTRWLDFAGGYSALRALRGREEPAAPTAQKSLSSLRLDPS-DDSVASPLDWLEEGIHWQCSSSDLEL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820987  154 KFKAQERALDSTAHTFLLEQQLWGVELLPGSLQTGLVSHRELGSSSSGPLSTQSLGNFKVVSYLLNPSYLDCLPQLELRC 233
Cdd:pfam10472 160 ELKAKGGALDPAAHAFLLEQQLWGVELLPSSLQAHLFSDRELGSSPSGPLNVQRLGNFNVVSYLLNPSYLDCLPRLELSC 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820987  234 QNSVGGGQLVDFRTLSPESCYLSEDACHPQPLCAEMSATAWRRCPPLSTEGLPEIHHLRMKRLEFL-QANKGQELPTPDQ 312
Cdd:pfam10472 240 QNSVGSGELVDFQTLTPESSCLSEDHCHPQPLNAEISAASWQGCPPLSREGLPEIHHLRMKRLEFLqQASKGQELPTPDQ 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820987  313 DNGYHSLEEEHCLLRMDPQHCTDKAAQAVSPAGASP----QPTEKKVELVVEEVL-----QSPQGSSLSCELSVQKECE- 382
Cdd:pfam10472 320 DNGYHSLEEEHSLLRMDLKHCRDNPTQCVPPAGAIPgtaqEPTEEKIELLTTEVPlalekQDPSGSCPSCEVPVEKEPGe 399
                         410
                  ....*....|..
gi 157820987  383 ------DYSDIG 388
Cdd:pfam10472 400 dqisvvDSSDIE 411
PP1c_bdg pfam10488
Phosphatase-1 catalytic subunit binding region; This conserved C-terminus appears to be a ...
391-673 6.96e-156

Phosphatase-1 catalytic subunit binding region; This conserved C-terminus appears to be a protein phosphatase-1 catalytic subunit (PP1C) binding region, which may in some circumstances also be retroviral in origin since it is found in both herpes simplex virus and in mouse and man. This domain is found in Gadd-34 apoptosis-associated proteins as well as the constitutive repressor of eIF2-alpha phosphorylation/protein phosphatase 1, regulatory (inhibitor) subunit 15b, otherwise known as CReP. Diverse stressful conditions are associated with phosphorylation of the {alpha} subunit of eukaryotic translation initiation factor 2 (eIF2{alpha}) on serine 51. This signaling event, which is conserved from yeast to mammals, negatively regulates the guanine nucleotide exchange factor, eIF2-B and inhibits the recycling of eIF2 to its active GTP bound form. In mammalian cells eIF2{alpha} phosphorylation emerges as an important event in stress signaling that impacts on gene expression at both the translational and transcriptional levels.


Pssm-ID: 431311  Cd Length: 287  Bit Score: 452.55  E-value: 6.96e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820987  391 LPVSTRPACTNKLIDYILGGASSDLDTSSDSESEDWDEEPEDDGFDSDGSLSESDREQDSEGLHLWNSFYSVDPYNPQNF 470
Cdd:pfam10488   1 LPISARPACSNKLIDYILGGASSDLETSSDSEGEDWDEEAEDDGFDSDGSLSESDKEQDSEGLHLWNSFYSVDPYNPQNF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820987  471 TATIQTAARIAPRDPSDSEKSWSGNSDVGS-SQATLLPQTPDQSSGEEDDWESSADEAENLRLWNSFCNSEDPYNLLNFK 549
Cdd:pfam10488  81 TATIQTAATIAPGDPSDSEKDLSDKSDLESvSQAESPPETPDHSSGEEDDWESSADEAESLKLWNSFCNSDDPYNPLNFR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820987  550 APFQTSGKSWKG---SQASSEATVVFSGHQTLLSCEAQLLESQEDNCPGCGLGEALSGERYTHIKRKKVTFLEEVTEYYI 626
Cdd:pfam10488 161 APFQTSGKNGKGcqdSKIPPESVVAISEGHALLSCKVQLLGSQERECPGLLQRGVLSGERHTSPKRKKVTFLEEVTEYYI 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 157820987  627 SGDEDRKGPWEEFARDGCRFQKRIQETEVAIGYCLTFEHRERVFSRL 673
Cdd:pfam10488 241 SGDEDRKGPWEEFARDGCRFQKRIQETEDAIGYCLTFEHREKMFNRL 287
 
Name Accession Description Interval E-value
CReP_N pfam10472
eIF2-alpha phosphatase phosphorylation constitutive repressor; This is the conserved ...
1-388 0e+00

eIF2-alpha phosphatase phosphorylation constitutive repressor; This is the conserved N-terminal domain of CReP, constitutive repressor of eIF2-alpha phosphorylation/protein phosphatase 1, catalytic subunit. It functions in the dephosphorylation of eIF2-alpha under basal conditions in the absence of stress. In response to translation inhibition, there is reduced synthesis of the labile CReP that contributes to elevated levels of eIF2-alpha phosphorylation. The C-terminus, family PP1c, is shared with the apoptosis-associated protein Gadd34 and herpes simplex virus.


Pssm-ID: 371074  Cd Length: 411  Bit Score: 594.10  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820987    1 METGTHRARKRPTSRMGSWFRLP--FLRRSHACTSEFPKPSSRPN-----LEVSARPEPRTRYWTKLLSQLLALLPSLLQ 73
Cdd:pfam10472   1 MEPGTDGSRKRPAPRAGSWFRLPffFPRRSQAGSSKFPTPPAPENsgdptLLSSAQPEARTSYWTKLLSQLLAPLPSLLQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820987   74 KLLIWSQLFGGMIPTRWLDFSASYSALRALRGREESAAPTVQKSLNSLRLDSSsEDLVVSSLDWLEEGLQGQCSSSDLEL 153
Cdd:pfam10472  81 KLLIWSQLFGGLIPTRWLDFAGGYSALRALRGREEPAAPTAQKSLSSLRLDPS-DDSVASPLDWLEEGIHWQCSSSDLEL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820987  154 KFKAQERALDSTAHTFLLEQQLWGVELLPGSLQTGLVSHRELGSSSSGPLSTQSLGNFKVVSYLLNPSYLDCLPQLELRC 233
Cdd:pfam10472 160 ELKAKGGALDPAAHAFLLEQQLWGVELLPSSLQAHLFSDRELGSSPSGPLNVQRLGNFNVVSYLLNPSYLDCLPRLELSC 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820987  234 QNSVGGGQLVDFRTLSPESCYLSEDACHPQPLCAEMSATAWRRCPPLSTEGLPEIHHLRMKRLEFL-QANKGQELPTPDQ 312
Cdd:pfam10472 240 QNSVGSGELVDFQTLTPESSCLSEDHCHPQPLNAEISAASWQGCPPLSREGLPEIHHLRMKRLEFLqQASKGQELPTPDQ 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820987  313 DNGYHSLEEEHCLLRMDPQHCTDKAAQAVSPAGASP----QPTEKKVELVVEEVL-----QSPQGSSLSCELSVQKECE- 382
Cdd:pfam10472 320 DNGYHSLEEEHSLLRMDLKHCRDNPTQCVPPAGAIPgtaqEPTEEKIELLTTEVPlalekQDPSGSCPSCEVPVEKEPGe 399
                         410
                  ....*....|..
gi 157820987  383 ------DYSDIG 388
Cdd:pfam10472 400 dqisvvDSSDIE 411
PP1c_bdg pfam10488
Phosphatase-1 catalytic subunit binding region; This conserved C-terminus appears to be a ...
391-673 6.96e-156

Phosphatase-1 catalytic subunit binding region; This conserved C-terminus appears to be a protein phosphatase-1 catalytic subunit (PP1C) binding region, which may in some circumstances also be retroviral in origin since it is found in both herpes simplex virus and in mouse and man. This domain is found in Gadd-34 apoptosis-associated proteins as well as the constitutive repressor of eIF2-alpha phosphorylation/protein phosphatase 1, regulatory (inhibitor) subunit 15b, otherwise known as CReP. Diverse stressful conditions are associated with phosphorylation of the {alpha} subunit of eukaryotic translation initiation factor 2 (eIF2{alpha}) on serine 51. This signaling event, which is conserved from yeast to mammals, negatively regulates the guanine nucleotide exchange factor, eIF2-B and inhibits the recycling of eIF2 to its active GTP bound form. In mammalian cells eIF2{alpha} phosphorylation emerges as an important event in stress signaling that impacts on gene expression at both the translational and transcriptional levels.


Pssm-ID: 431311  Cd Length: 287  Bit Score: 452.55  E-value: 6.96e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820987  391 LPVSTRPACTNKLIDYILGGASSDLDTSSDSESEDWDEEPEDDGFDSDGSLSESDREQDSEGLHLWNSFYSVDPYNPQNF 470
Cdd:pfam10488   1 LPISARPACSNKLIDYILGGASSDLETSSDSEGEDWDEEAEDDGFDSDGSLSESDKEQDSEGLHLWNSFYSVDPYNPQNF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820987  471 TATIQTAARIAPRDPSDSEKSWSGNSDVGS-SQATLLPQTPDQSSGEEDDWESSADEAENLRLWNSFCNSEDPYNLLNFK 549
Cdd:pfam10488  81 TATIQTAATIAPGDPSDSEKDLSDKSDLESvSQAESPPETPDHSSGEEDDWESSADEAESLKLWNSFCNSDDPYNPLNFR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157820987  550 APFQTSGKSWKG---SQASSEATVVFSGHQTLLSCEAQLLESQEDNCPGCGLGEALSGERYTHIKRKKVTFLEEVTEYYI 626
Cdd:pfam10488 161 APFQTSGKNGKGcqdSKIPPESVVAISEGHALLSCKVQLLGSQERECPGLLQRGVLSGERHTSPKRKKVTFLEEVTEYYI 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 157820987  627 SGDEDRKGPWEEFARDGCRFQKRIQETEVAIGYCLTFEHRERVFSRL 673
Cdd:pfam10488 241 SGDEDRKGPWEEFARDGCRFQKRIQETEDAIGYCLTFEHREKMFNRL 287
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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