F-box domain found in F-box/WD repeat-containing protein 8 (FBXW8) and similar proteins; FBXW8, also called F-box and WD-40 domain-containing protein 8, or F-box only protein 29 (FBXO29), is the substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as GORASP1, IRS1, MAP4K1/HPK1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2020023481 111 PFFDVHLPYELAINIFQYLNRRELGLCAQVSKTWKVIAEDEVLWYRLC 158
Cdd:cd22134     1 PFFDIQLPRELALKIFQYLSVTDLCRCAQVSKSWKSLAEDELLWYRIC 48

F-box domain found in F-box/WD repeat-containing protein 8 (FBXW8) and similar proteins; FBXW8, also called F-box and WD-40 domain-containing protein 8, or F-box only protein 29 (FBXO29), is the substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as GORASP1, IRS1, MAP4K1/HPK1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2020023481 111 PFFDVHLPYELAINIFQYLNRRELGLCAQVSKTWKVIAEDEVLWYRLC 158
Cdd:cd22134     1 PFFDIQLPRELALKIFQYLSVTDLCRCAQVSKSWKSLAEDELLWYRIC 48

F-box-like; This is an F-box-like family.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2020023481 116 HLPYELAINIFQYLNRRELGLCAQVSKTWKVIAEDEVLWYRLC 158
Cdd:pfam12937   3 SLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWRRLC 45

A Receptor for Ubiquitination Targets;

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2020023481  117 LPYELAINIFQYLNRRELGLCAQVSKTWKVIAEDEVLWYRL 157
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41

F-box domain found in F-box/WD repeat-containing protein 8 (FBXW8) and similar proteins; FBXW8, also called F-box and WD-40 domain-containing protein 8, or F-box only protein 29 (FBXO29), is the substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as GORASP1, IRS1, MAP4K1/HPK1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2020023481 111 PFFDVHLPYELAINIFQYLNRRELGLCAQVSKTWKVIAEDEVLWYRLC 158
Cdd:cd22134     1 PFFDIQLPRELALKIFQYLSVTDLCRCAQVSKSWKSLAEDELLWYRIC 48

WD40 repeat [General function prediction only];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020023481 183 LAREHKLRANWKNRKGAVSELEHVPDAVLCDVRSHDGVVIAGYTSGEVRVWDTRTWDYVAPFLESESeeedpgmQPYVSF 262
Cdd:COG2319    13 SADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTA-------AVLSVA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020023481 263 VRINSSLAVAAYEDGILNVWDLRTGRFPIFRFEHDARIQALALSQEKPVVATASAFDVVMLypneegnWHVASEFEVQKL 342
Cdd:COG2319    86 FSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRL-------WDLATGKLLRTL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020023481 343 ------VDYLEIVPNtGRYpvaIATAGD--LVYLLKAeDSARTLHYVYGQPATCLDVSAS----QVAFGVkslgwvyEGN 410
Cdd:COG2319   159 tghsgaVTSVAFSPD-GKL---LASGSDdgTVRLWDL-ATGKLLRTLTGHTGAVRSVAFSpdgkLLASGS-------ADG 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020023481 411 KILVYSLEAERCLSKLGNALGDFTCVNIrdSP-PNLMVSGNMDRRVRLHDLRTDKIALSLSAHQLGVSAVQM--DDWKIV 487
Cdd:COG2319   227 TVRLWDLATGKLLRTLTGHSGSVRSVAF--SPdGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFspDGKLLA 304

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 2020023481 488 SGGEEGLVSVWDYRMNQKLWeVHSRH--PVRYISF--NSHSLITA 528
Cdd:COG2319   305 SGSDDGTVRLWDLATGKLLR-TLTGHtgAVRSVAFspDGKTLASG 348

WD40 repeat [General function prediction only];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020023481 200 VSELEHVPDAVLCDVRSHDGVVIA-GYTSGEVRVWDTRTWDYVAPFleseseeedPGMQPYVSFVRI--NSSLAVAAYED 276
Cdd:COG2319   155 LRTLTGHSGAVTSVAFSPDGKLLAsGSDDGTVRLWDLATGKLLRTL---------TGHTGAVRSVAFspDGKLLASGSAD 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020023481 277 GILNVWDLRTGRFPIFRFEHDARIQALALSQEKPVVATASAFDVVMLypneegnWHVASEFEVQKL------VDYLEIVP 350
Cdd:COG2319   226 GTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRL-------WDLATGELLRTLtghsggVNSVAFSP 298

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020023481 351 NtGRYpVAIATAGDLVYLLKAeDSARTLHYVYGQPATCLDVSAS----QVAFGvkslgwvYEGNKILVYSLEAERCLSKL 426
Cdd:COG2319   299 D-GKL-LASGSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAFSpdgkTLASG-------SDDGTVRLWDLATGELLRTL 368

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2020023481 427 GNALGDFTCVNIrdSPP-NLMVSGNMDRRVRLHDLRT 462
Cdd:COG2319   369 TGHTGAVTSVAF--SPDgRTLASGSADGTVRLWDLAT 403

F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar proteins; SpPof1, also called F-box/WD repeat-containing protein pof1, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is required for the inactivation of zip1 via ubiquitination. This subfamily also includes Saccharomyces cerevisiae methionine-requiring protein 30 (ScMET30, also called E3 ubiquitin ligase complex SCF(Met30) subunit MET30), Aspergillus niger sulfur controller B (AnSCONB, also called sulfur metabolite repression control protein B) and Neurospora crassa sulfur controller 2 (NcSCON2, also called sulfur metabolite repression control protein 2). ScMET30 acts as a transcriptional inhibitor that negatively regulates the expression of sulfur amino acid biosynthesis genes. It controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the E3 ubiquitin ligase complex SCF(Met30). AnSCONB and NcSCON2 are components of the SCF (sconB/scon-2) E3 ubiquitin ligase complexes involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2020023481 117 LPYELAINIFQYLNRRELGLCAQVSKTWKVIAEDEVLWYRLC 158
Cdd:cd22147     5 LPVELSLKILSYLDAKSLCRAAQVSKKWRNLADDDELWKRMC 46

F-box domain found in Dictyostelium discoideum Rho GTPase-activating protein gacFF (DdgacFF) and similar proteins; DdgacFF, also called GTPase activating factor for raC protein FF, is a Rho GTPase-activating protein involved in the signal transduction pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2020023481 117 LPYELAINIFQYLNRRELGLCAQVSKTWKVIAEDEVLW 154
Cdd:cd22148     5 LPEHLALKILSYLSPKELLIASQVSKTWRRLASSNELW 42

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020023481 434 TCVNIrDSPPNLMVSGNMDRRVRLHDLRTDKIALSLSAHQLGVSAVQMDDW--KIVSGGEEGLVSVWDYRMNQKLWEVHS 511
Cdd:cd00200    13 TCVAF-SPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADgtYLASGSSDKTIRLWDLETGECVRTLTG 91

                          90
                  ....*....|....*.
gi 2020023481 512 -RHPVRYISFNSHSLI 526
Cdd:cd00200    92 hTSYVSSVAFSPDGRI 107

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020023481 260 VSFVRINSSLAVAAYeDGILNVWDLRTGRFPIFRFEHDARIQALALSQEKPVVATASAFDVVmlypneegnwhvasefev 339
Cdd:cd00200    15 VAFSPDGKLLATGSG-DGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTI------------------ 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020023481 340 qKLVDyleivpntgrypvaiatagdlvylLKAEDSARTLH----YVYgqpatCLDVSAS-QVAFGVkslgwvYEGNKILV 414
Cdd:cd00200    76 -RLWD------------------------LETGECVRTLTghtsYVS-----SVAFSPDgRILSSS------SRDKTIKV 119

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020023481 415 YSLEAERCLSKLGNALGDFTCVNIrdSPPNLMV-SGNMDRRVRLHDLRTDKIALSLSAHQLGVSAVQM--DDWKIVSGGE 491
Cdd:cd00200   120 WDVETGKCLTTLRGHTDWVNSVAF--SPDGTFVaSSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFspDGEKLLSSSS 197

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2020023481 492 EGLVSVWDYRMNQKLwEVHSRH--PVRYISFNSHSLITANVPYEKVLRNSDLDNFACHRR---HRGLIHA 556
Cdd:cd00200   198 DGTIKLWDLSTGKCL-GTLRGHenGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTlsgHTNSVTS 266

F-box domain found in F-box only protein 8 (FBXO8) and similar proteins; FBXO8, also called FBX8, or F-box/SEC7 protein FBS, is a novel component of F-box proteins which contains an F-box domain and a putative Sec7 domain. FBX8 was originally identified as a Skp1-binding protein. It is involved in the ubiquitin-dependent proteolytic pathway. It acts as a metastasis suppressor that functions through mTOR signaling pathway. FBXO8 may promote the activation of ADP-ribosylation factor (ARF) through replacement of GDP with GTP. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2020023481 117 LPYELAINIFQYLNRRELGLCAQVsktWKVIAEDEVLWYRLCR 159
Cdd:cd22088     7 LPPELSLTVLSHLNATDLCLASCV---WQDLANDELLWQGLCR 46

F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called FBX11, protein arginine N-methyltransferase 9 (PRMT9), or vitiligo-associated protein 1 (VIT-1), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2020023481 116 HLPYELAINIFQYLNRRELGLCAQVSKTWKVIAEDEVLWYRL 157
Cdd:cd22091     3 ELPDEVLLKIFSYLLEQDLCRAAQVCKRFNTLANDPELWKRL 44

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.

                          10        20        30
                  ....*....|....*....|....*....|....
gi 2020023481 116 HLPYELAINIFQYLNRRELGLCAQVSKTWKVIAE 149
Cdd:cd09917     2 DLPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35

F-box domain found in F-box only protein 16 (FBXO16), epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and similar proteins; This family includes FBXO16 and ECT2L. FBXO16, also called FBX16, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It functions as a tumor suppressor by attenuating nuclear beta-catenin function. ECT2L, also called lung-specific F-box and DH domain-containing protein, or putative guanine nucleotide exchange factor LFDH, may act as a guanine nucleotide exchange factor (GEF). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2020023481 113 FDVHLPYELAINIFQYLNRRELGLCAQVSKTWKVIAEDEVLWYRLC 158
Cdd:cd22094     2 FTRVLPRFLSLYIFSYLDPRSLCRAAQVSWYWKFLCESDELWLPKC 47

F-box domain found in F-box/LRR-repeat protein 2 (FBXL2), F-box/LRR-repeat protein 20 (FBXL20) and similar proteins; The family includes FBXL2 and FBXL30. FBXL2, also called F-box and leucine-rich repeat protein 2, or F-box protein FBL2/FBL3, is a calcium-activated substrate-recognition component of an SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. FBXL20, also called SCRAPPER, F-box and leucine-rich repeat protein 20, or F-box/LRR-repeat protein 2-like, is a component of a synapse-localized SCF-type E3 ubiquitin ligase which regulates neural transmission. It is widely expressed in the central nervous system and plays an important role in the ubiquitin-dependent degradation of regulating synaptic membrane exocytosis 1 (RIM1), which is an important factor in the release of synaptic vesicles. It may also mediate the ubiquitin degradation of E-cadherin resulting in an increased invasive ability of malignant cells. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2020023481 117 LPYELAINIFQYLNRRELGLCAQVSKTWKVIAEDEVLW 154
Cdd:cd22115     7 LPKELLLRIFSFLDVVTLCRCAQVSKYWNVLALDGSNW 44

F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2020023481 116 HLPYELAINIFQYLNRRELGLCAQVSKTWKVIAEDEVLWYRLCRQ 160
Cdd:cd22084     3 DLPSDPLLNILSFLDYRDLISCSQVCRRLNQLCSHDPLWKRLCKK 47

F-box domain found in F-box only protein 16 (FBXO16) and similar proteins; FBXO16, also called FBX16, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It functions as a tumor suppressor by attenuating nuclear beta-catenin function. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2020023481 117 LPYELAINIFQYLNRRELGLCAQVSKTWKVIAEDEVLWYRLC 158
Cdd:cd22172     9 LPRVLSLYIFSFLDPRSLCRCAQVCWYWKYLTELDQLWMPKC 50

F-box domain found in Saccharomyces cerevisiae cell division control protein 4 (ScCDC4) and similar proteins; ScCDC4 is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It is essential for initiation of DNA replication and separation of the spindle pole bodies to form the poles of the mitotic spindle. It also plays a role in bud development, fusion of zygotic nuclei after conjugation and various aspects of sporulation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2020023481 117 LPYELAINIFQYLNRRELGLCAQVSKTWKVIAEDEVLWYRLC 158
Cdd:cd22141     4 LPFEISLKIFNYLQFEDLLNSLGVSKKWNKIIRNTALWKKLL 45

F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called FBX41, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a novel central nervous system (CNS)-specific F-box protein that localizes to the centrosome and the cytoplasm of neurons and promotes neuronal migration. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|....
gi 2020023481 125 IFQYLNRRELGLCAQVSKTWKVIAEDEVLWYRLC 158
Cdd:cd22109    14 VFSYLDTKSLLRCAEVCREWRDVSRHPALWQRVC 47

F-box domain found in F-box only protein 10 (FBXO10) and similar proteins; FBXO10, also called FBX10, or PRMT11, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an anti-apoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2. It also associates with the receptor for advanced glycation end products (RAGE) to mediate its ubiquitination and degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2020023481 117 LPYELAINIFQYLNRRELGLCAQVSKTWK--VIAEDEVLWYRLC 158
Cdd:cd22090     5 LPLELWRLILAYLPVRDLCRCCQVCRAWYelILSLDSTRWKQLY 48

F-box domain found in F-box only protein 31 (FBXO31) and similar proteins; FBXO31, also called FBX31, or FBXO14, is a component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. It specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. FBXO31 may act as a tumor suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 2020023481 116 HLPYELAINIFQYLNRRELGLCAQVSKTWKVIAEDEVLWYRLCRQE 161
Cdd:cd22102     3 DLPPELLVEIFSSLPGTDLPSLAQVCKKFREILNTDTIWQRRCKEE 48

F-box domain found in F-box only protein 32 (FBXO32) and similar proteins; FBXO32, also called FBX32, atrogin-1, or muscle atrophy F-box protein (MAFbx), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during skeletal muscle atrophy. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2020023481 117 LPYELAINIFQYL-NRRELGLCAQVSKTWKVIAEDEVLWYRLC 158
Cdd:cd22103     6 LPLCLQLNIMQRLsDGRDIVSLGQVSPDLQVLSEDRLLWKKLC 48

F-box domain found in F-box/LRR-repeat protein 11 (FBXL11) and similar proteins; FBXL11, also called lysine-specific demethylase 2A (KDM2A), CXXC-type zinc finger protein (CXXC8), F-box and leucine-rich repeat protein 11, F-box protein FBL7, F-box protein Lilina, JmjC domain-containing histone demethylation protein 1A (JHDM1A), or [Histone-H3]-lysine-36 demethylase 1A, is a histone H3 lysine 36 (H3K36) demethylase that regulates epithelial mesenchymal transition (EMT) and the metastasis of ovarian cancer. It plays an essential role in embryonic development and homeostasis by regulating cell proliferation and survival. FBXL11 may also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. It associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. It is required to sustain centromeric integrity and genomic stability, particularly during mitosis. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2020023481 120 ELAINIFQYLNRRELGLCAQVSKTWKVIAEDEVLWYR 156
Cdd:cd22181    11 DVWMSVFRYLSRRELCECMRVCKTWYKWCCDKRLWTK 47

F-box domain found in F-box/LRR-repeat protein 7 (FBXL7) and similar proteins; FBXL7, also called F-box and leucine-rich repeat protein 7, or F-box protein FBL6/FBL7, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of Aurora kinase A (AURKA) during mitosis, causing mitotic arrest. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2020023481 117 LPYELAINIFQYLNRRELGLCAQVSKTWKVIAEDEVLW 154
Cdd:cd22120     4 LPDDVILQIFSHLPTNQLCRCARVCRRWYNLAWDPRLW 41

F-box domain found in F-box/LRR-repeat protein 8 (FBXL8) and similar proteins; FBXL8, also called F-box and leucine-rich repeat protein 8, or F-box protein FBL8, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|...
gi 2020023481 116 HLPYELAINIFQYLNRRELGLCAQVSKTWKVIA 148
Cdd:cd22121     2 ALPEEILVHIFRHLSLRDRYAAAQVCKHWREAA 34

F-box domain found in F-box only protein 4 (FBXO4) and similar proteins; FBXO4, also called FBX4, is a specific substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that catalyzes the ubiquitination and subsequent degradation of cyclin D1 and Trx1. It recognizes TERF1 and promotes its ubiquitination together with UBE2D1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2020023481 116 HLPYELAINIFQYLNRRELGLCAQVSKTWKVIAEDEVLWYRLCR 159
Cdd:cd22085     5 HLPIDLQLYILSFLSPHDLCQLGLTSHYWHTLVRDPLLWRYFLL 48