NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|157821675|ref|NP_001100168|]
View 

GDH/6PGL endoplasmic bifunctional protein precursor [Rattus norvegicus]

Protein Classification

6-phosphogluconolactonase; sugar phosphate isomerase family( domain architecture ID 13232975)

6-phosphogluconolactonase catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate, which is the the second step of the oxidative phase of the pentose phosphate pathway| sugar phosphate isomerase family

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
PTZ00309 super family cl29403
glucose-6-phosphate 1-dehydrogenase; Provisional
31-510 1.40e-94

glucose-6-phosphate 1-dehydrogenase; Provisional


The actual alignment was detected with superfamily member PTZ00309:

Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 305.91  E-value: 1.40e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  31 VSIILLGATGDLAKKYLWQGLFQLYLDeaGK-GHSFSFHGAALTAPQQGQKLMDKALeslscPKDLVPSRCDELKA-QFL 108
Cdd:PTZ00309  55 LTIIVLGASGDLAKKKTFPALFQLYCE--GLlPSEVNIVGYARSKMSDVERWKKETL-----ARFFKRLDDRECHLeQFL 127
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 109 QLSQYR--QLKTVEDYQTLNKDIETQVQQDGLWEAG--RVFYFSVPPFAYADIARNINSSCRPHPGaWLRVVFEKPFGHD 184
Cdd:PTZ00309 128 KHISYIsgSYDEDEDFKRLNKLIERMEEAFQGPEKGgnRLFYLALPPSVFASVCEGIHRGCMSKNG-WVRVIVEKPFGRD 206
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 185 HLSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETVDAGGRASFYEEYGV 264
Cdd:PTZ00309 207 LESSEELSNQLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANR-VFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSYGI 285
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 265 IRDTLQNHLTEILTLVAMElPPNISSSAAVLQHKLQAFQALRGLQKSNAILGQYQAYSGQ----VRQELQKPDGfqSLTP 340
Cdd:PTZ00309 286 IRDVMQNHLLQILALLAME-KPVSLSAEDIRDEKVKVLKCIEPIKMEECVLGQYTASADGsipgYLEDEGVPKD--STTP 362
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 341 TFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRILFKNrayctqgerhwVPErsrclpqqIVFY---IGHGEL----- 412
Cdd:PTZ00309 363 TFAAAVLHINNDRWEGVPFILEAGKALEERYVEIRIQFKG-----------VDE--------FRPSgddTQRNELviraq 423
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 413 GHPAILVSKNLFKPSLPAQSWKGVQDQPGLHLFGrplsdyyayrpVREQDAYSTLLSHIFHCRKESFITTENLLASWVFW 492
Cdd:PTZ00309 424 PSEAMYLKITAKVPGLSNDLHQTELDLTYKTRYN-----------VRLPDAYERLILDALLGDSTNFVRKDELDVAWRIF 492
                        490       500
                 ....*....|....*....|
gi 157821675 493 TPLLDSL-SFEV-PRLYPGG 510
Cdd:PTZ00309 493 TPLLHQIdRGEVkPEPYPFG 512
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
562-797 1.20e-90

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


:

Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 284.65  E-value: 1.20e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  562 ITAWPEELISKLANDIEAAAVQAVRRFGKFHLALSGGSSPIALFQQLATGhySFPWAYTHLWLVDERCVPLSDPDSNFQG 641
Cdd:TIGR01198   1 VFSNSAELAEALAERIATKLQTALAERGQFSLALSGGRSPIALLEALAAQ--PLDWSRIHLFLGDERYVPLDHADSNTGL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  642 LQAHLLQHVRVPYYNIHPMPVHLhqrlcAEEDQGAQTYASEISALVAN---SSFDLVLLGMGTDGHTASLFPQSPRGLDG 718
Cdd:TIGR01198  79 AREALLDRVAIPASNIHPMPTEL-----SDIEEAAELYEQELAAAFQPivfPVFDLLLLGMGPDGHTASLFPHTPALQET 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  719 DQLV-VLTESPFRPHQRMSLSLPLINRAKKVAVLVMGRTKREITTLVSRVGHEPKKWPISGVVPlSGQLVWYMDYEAFLG 797
Cdd:TIGR01198 154 ERLVtVLTKSPKPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALAVEAEPYPLPAAGVLH-SGKTLWLLDYAAARK 232
 
Name Accession Description Interval E-value
PTZ00309 PTZ00309
glucose-6-phosphate 1-dehydrogenase; Provisional
31-510 1.40e-94

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 305.91  E-value: 1.40e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  31 VSIILLGATGDLAKKYLWQGLFQLYLDeaGK-GHSFSFHGAALTAPQQGQKLMDKALeslscPKDLVPSRCDELKA-QFL 108
Cdd:PTZ00309  55 LTIIVLGASGDLAKKKTFPALFQLYCE--GLlPSEVNIVGYARSKMSDVERWKKETL-----ARFFKRLDDRECHLeQFL 127
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 109 QLSQYR--QLKTVEDYQTLNKDIETQVQQDGLWEAG--RVFYFSVPPFAYADIARNINSSCRPHPGaWLRVVFEKPFGHD 184
Cdd:PTZ00309 128 KHISYIsgSYDEDEDFKRLNKLIERMEEAFQGPEKGgnRLFYLALPPSVFASVCEGIHRGCMSKNG-WVRVIVEKPFGRD 206
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 185 HLSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETVDAGGRASFYEEYGV 264
Cdd:PTZ00309 207 LESSEELSNQLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANR-VFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSYGI 285
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 265 IRDTLQNHLTEILTLVAMElPPNISSSAAVLQHKLQAFQALRGLQKSNAILGQYQAYSGQ----VRQELQKPDGfqSLTP 340
Cdd:PTZ00309 286 IRDVMQNHLLQILALLAME-KPVSLSAEDIRDEKVKVLKCIEPIKMEECVLGQYTASADGsipgYLEDEGVPKD--STTP 362
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 341 TFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRILFKNrayctqgerhwVPErsrclpqqIVFY---IGHGEL----- 412
Cdd:PTZ00309 363 TFAAAVLHINNDRWEGVPFILEAGKALEERYVEIRIQFKG-----------VDE--------FRPSgddTQRNELviraq 423
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 413 GHPAILVSKNLFKPSLPAQSWKGVQDQPGLHLFGrplsdyyayrpVREQDAYSTLLSHIFHCRKESFITTENLLASWVFW 492
Cdd:PTZ00309 424 PSEAMYLKITAKVPGLSNDLHQTELDLTYKTRYN-----------VRLPDAYERLILDALLGDSTNFVRKDELDVAWRIF 492
                        490       500
                 ....*....|....*....|
gi 157821675 493 TPLLDSL-SFEV-PRLYPGG 510
Cdd:PTZ00309 493 TPLLHQIdRGEVkPEPYPFG 512
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
562-797 1.20e-90

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 284.65  E-value: 1.20e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  562 ITAWPEELISKLANDIEAAAVQAVRRFGKFHLALSGGSSPIALFQQLATGhySFPWAYTHLWLVDERCVPLSDPDSNFQG 641
Cdd:TIGR01198   1 VFSNSAELAEALAERIATKLQTALAERGQFSLALSGGRSPIALLEALAAQ--PLDWSRIHLFLGDERYVPLDHADSNTGL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  642 LQAHLLQHVRVPYYNIHPMPVHLhqrlcAEEDQGAQTYASEISALVAN---SSFDLVLLGMGTDGHTASLFPQSPRGLDG 718
Cdd:TIGR01198  79 AREALLDRVAIPASNIHPMPTEL-----SDIEEAAELYEQELAAAFQPivfPVFDLLLLGMGPDGHTASLFPHTPALQET 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  719 DQLV-VLTESPFRPHQRMSLSLPLINRAKKVAVLVMGRTKREITTLVSRVGHEPKKWPISGVVPlSGQLVWYMDYEAFLG 797
Cdd:TIGR01198 154 ERLVtVLTKSPKPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALAVEAEPYPLPAAGVLH-SGKTLWLLDYAAARK 232
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
564-788 3.61e-83

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 264.48  E-value: 3.61e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  564 AWPEELISKLANDIEAAAVQAVRRFGKFHLALSGGSSPIALFQQLATGHYSFPWAYTHLWLVDERCVPLSDPDSNFQGLQ 643
Cdd:pfam01182   1 PDAEALAQALAERLAEALEAALAERGRFTLALSGGSTPKPLYELLAAAPARLDWSRVHVFWGDERCVPPDDPDSNYGMAR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  644 AHLLQHVRVPYYNIHPMPVHLhqrlcAEEDQGAQTYASEISALVANSS---FDLVLLGMGTDGHTASLFPQSPRGLDGDQ 720
Cdd:pfam01182  81 EALLSHVPIPASNVHPIPASA-----ADPEEAAAAYEAELRELLPDLElpvFDLVLLGMGPDGHTASLFPGSPALEETDR 155
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  721 LVV-LTESPFRPHQRMSLSLPLINRAKKVAVLVMGRTKREIttlVSRV-GHEPKKWPISGVVPLSGQLVW 788
Cdd:pfam01182 156 LVVaVTDSPKPPPERITLTLPVLNAARRVWFLVTGAGKADA---LRRAlAGDPDPLPAALVRPGAGETVW 222
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
33-510 4.44e-83

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 273.43  E-value: 4.44e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675   33 IILLGATGDLAKKYLWQGLFQLY----LDEagkghSFSFHGAALTAPQQGQ--KLMDKALESlSCPKDLvpsrcDELKAQ 106
Cdd:TIGR00871   5 LVIFGASGDLARKKLFPALYRLFrnglLPP-----DFRIVGVARRDWSVEEfrKVVREAIIK-FETDEI-----DEQWDE 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  107 FLQLSQYR--QLKTVEDYQTLNKDIEtQVQQDGLWEAGRVFYFSVPPFAYADIARNINSSCRPHPGAWLRVVFEKPFGHD 184
Cdd:TIGR00871  74 FAQRLSYVsgDVDDDESYDSLAELLE-QLDKTYGTEGNRLFYLATPPSLFGTIIKQLKKHGLNEQGKWSRVVVEKPFGHD 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  185 HLSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETVDAGGRASFYEEYGV 264
Cdd:TIGR00871 153 LASAQELNKALRAVFKEDQIYRIDHYLGKETVQNLLVLRFANQ-IFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGA 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  265 IRDTLQNHLTEILTLVAMElPPNISSSAAVLQHKLQAFQALRGLQK--SNAILGQYQAysGQVRQElQKP-----DGF-- 335
Cdd:TIGR00871 232 LRDMVQNHLLQLLALVAME-PPVSFDADSIRDEKVKVLKALRPIDPddNNTVRGQYGA--GEIGGV-SVPgyleeEGVdk 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  336 QSLTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRILFKNrayctqgerhwVP-------ERSRCLPQQIVFYIG 408
Cdd:TIGR00871 308 DSNTETFAALKLEIDNWRWAGVPFYLRTGKRLPEKVTEIRIQFRD-----------VPsllfkanERDANPRNALVIRIQ 376
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  409 HGElghpAILVSKNLFKPSLPAQswkgVQDqpgLHLFGRPLSDYYAYRPvreqDAYSTLLSHIFHCRKESFITTENLLAS 488
Cdd:TIGR00871 377 PDE----GVYLKFNAKKPGLNFE----TRP---VKLDFSYASRFGELLP----EAYERLLLDALLGDHTLFARDDEVEEA 441
                         490       500
                  ....*....|....*....|....*
gi 157821675  489 WVFWTPLLDSL---SFEVPRLYPGG 510
Cdd:TIGR00871 442 WRIVTPILEAWaanKGPSPPNYPAG 466
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
567-790 1.47e-78

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 252.10  E-value: 1.47e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 567 EELISKLANDIEAAAVQAVRRFGKFHLALSGGSSPIALFQQLATGhYSFPWAYTHLWLVDERCVPLSDPDSNFQGLQAHL 646
Cdd:cd01400    1 EALAEALADRIAEALAAAIAKRGRFSLALSGGSTPKPLYELLAAA-PALDWSKVHVFLGDERCVPPDDPDSNYRLAREAL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 647 LQHVRVPYYNIHPMPVHLHqrlcaeEDQGAQTYASEISALVANS-SFDLVLLGMGTDGHTASLFPQSPR-GLDGDQLVVL 724
Cdd:cd01400   80 LSHVAIPAANIHPIPTELG------PEDAAAAYEKELRALFGGVpPFDLVLLGMGPDGHTASLFPGHPAlLEETDRLVVA 153
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157821675 725 TE-SPFRPHQRMSLSLPLINRAKKVAVLVMGRTKREIttlVSRV--GHEPKKWPISGVVPLSGQLVWYM 790
Cdd:cd01400  154 VTdSPKPPPERITLTLPVLNNARRVVFLVTGAEKAEA---LKRAlaGPDPEELPAARVLPRPGEVLWFL 219
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
33-380 1.98e-78

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 261.55  E-value: 1.98e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  33 IILLGATGDLAKKYLWQGLFQLYLDeagkGH---SFSFHGAALTaPQQGQKLMDKALESLscpKDLVPSRCDELK-AQFL 108
Cdd:COG0364   12 LVIFGATGDLARRKLLPALYNLYRD----GLlpeGFRIIGVARR-DWSDEEFREEVREAL---EEFSRKPFDEEVwERFL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 109 QLSQYRQL--KTVEDYQTLNKDIEtqvQQDGLWEAG-RVFYFSVPPFAYADIARNINSSCRPHPGAWLRVVFEKPFGHDH 185
Cdd:COG0364   84 ERLHYVSGdfTDPEGYERLKELLE---ELDEERTPGnRVFYLATPPSLFGPICENLGAAGLATEGGWRRVVIEKPFGHDL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 186 LSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETVDAGGRASFYEEYGVI 265
Cdd:COG0364  161 ASARELNDELGRVFDESQIYRIDHYLGKETVQNLLALRFANA-LFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGAL 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 266 RDTLQNHLTEILTLVAMElPPNISSSAAVLQHKLQAFQALRGLQKS----NAILGQYQAysGQV--------RQElqkpD 333
Cdd:COG0364  240 RDMVQNHLLQLLCLVAME-PPASLDADAIRDEKVKVLRALRPITPEdvaeNTVRGQYTA--GWIggepvpgyREE----P 312
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 157821675 334 GF--QSLTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRILFKN 380
Cdd:COG0364  313 GVapDSTTETFVALKLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKP 361
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
233-518 1.13e-64

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 217.69  E-value: 1.13e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  233 LWNRHHVERVEIILKETVDAGGRASFYEEYGVIRDTLQNHLTEILTLVAMElPPNISSSAAVLQHKLQAFQALRGLQKS- 311
Cdd:pfam02781  13 LWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAME-PPVSFDAEDIRDEKVKVLRSLRPITPEd 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  312 ---NAILGQYQA--YSGQV----RQELQKPDGfqSLTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRILFKNra 382
Cdd:pfam02781  92 vedNVVRGQYGAgwIGGEPvpgyREEEGVPPD--SRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVTEIRIQFKD-- 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  383 yctqgerhwVP-----ERSRCLPQQIVFYIGHGElghpAILVSKNLFKpslpaqswkgvqdqPGLHLFGRPLS---DYYA 454
Cdd:pfam02781 168 ---------VPhnlfrDPGTLPPNELVIRIQPDE----GIYLKFNAKV--------------PGLGMRLRPVEldfSYSD 220
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157821675  455 YRPVREQDAYSTLLSHIFHCRKESFITTENLLASWVFWTPLLDSLSFEVPRLYPGG----AENDHLLD 518
Cdd:pfam02781 221 RFGERIPEAYERLLLDVMRGDQTLFVRSDEVEAAWRIVDPILEAWDEEKPPPYPAGswgpKAADELLA 288
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
566-794 4.14e-55

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 189.99  E-value: 4.14e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 566 PEELISKLANDIEAAAVQAVRRFGKFHLALSGGSSPIALFQQLATGHYS--FPWAYTHLWLVDERC-VPLSDPDSNFQGL 642
Cdd:COG0363   10 AEELAAAAAERAAERIAEAIAEKGRAVLGLAGGSTPLGLYEELARLHKEggLDWSRVHVFNLDEYVgLPPDHPQSNRRFM 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 643 QAHLLQHVRVPYYNIHPMPVHLhqrlcAEEDQGAQTYASEISALvanSSFDLVLLGMGTDGHTASLFPQSPRGLDGDQLV 722
Cdd:COG0363   90 REALLDHVDIPPENIHIPDGEA-----EDPEAAAARYEALIAEA---GGIDLQLLGIGEDGHIAFNFPGSPFLSETDRVV 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 723 VLTESPFR------------PHQRMSLSLPLINRAKKVAVLVMGRTKREIttlVSRV--GHEPKKWPISGVVPLSgQLVW 788
Cdd:COG0363  162 TLDESTRQanarffgsipkvPPQAITLGIPTIMKAREILLLATGENKAEA---VAAAleGPVTEEVPASILQGHP-NVTW 237

                 ....*.
gi 157821675 789 YMDYEA 794
Cdd:COG0363  238 FLDEAA 243
PLN02360 PLN02360
probable 6-phosphogluconolactonase
567-794 3.17e-30

probable 6-phosphogluconolactonase


Pssm-ID: 166001 [Multi-domain]  Cd Length: 268  Bit Score: 120.35  E-value: 3.17e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 567 EELISKLANDIEAAAVQAVRRFGKFHLALSGGSSpIALFQQLATGHY--SFPWAYTHLWLVDERCVPLSDPDSNFQGLQA 644
Cdd:PLN02360  20 DELSTDLAEYIAELSEASVKERGVFAIALSGGSL-ISFMGKLCEAPYnkTVDWAKWYIFWADERVVAKNHADSNYKLAKD 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 645 HLLQHVRVPYYNIHPmpvhLHQRLCAEEdqGAQTYASEISALVANSS-----------FDLVLLGMGTDGHTASLFPQSP 713
Cdd:PLN02360  99 GLLSKVPVVPSHVYS----INDTVTAEE--AATDYEFAIRQLVKTRTigvsdisdcpkFDLILLGMGSDGHVASLFPNHP 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 714 R-GLDGDQLVVLTESPFRPHQRMSLSLPLINRAKKVAVLVMGRTKREITTL-VSRVGHEP--KKWPISGVVPLSGQLVWY 789
Cdd:PLN02360 173 AlEEKDDWVTFITDSPKPPPERITFTLPVINSASNVAVVATGESKANAVHLaIDDVTEGPdaPSLPARMVQPTKGKLVWF 252

                 ....*
gi 157821675 790 MDYEA 794
Cdd:PLN02360 253 LDKPA 257
 
Name Accession Description Interval E-value
PTZ00309 PTZ00309
glucose-6-phosphate 1-dehydrogenase; Provisional
31-510 1.40e-94

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 305.91  E-value: 1.40e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  31 VSIILLGATGDLAKKYLWQGLFQLYLDeaGK-GHSFSFHGAALTAPQQGQKLMDKALeslscPKDLVPSRCDELKA-QFL 108
Cdd:PTZ00309  55 LTIIVLGASGDLAKKKTFPALFQLYCE--GLlPSEVNIVGYARSKMSDVERWKKETL-----ARFFKRLDDRECHLeQFL 127
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 109 QLSQYR--QLKTVEDYQTLNKDIETQVQQDGLWEAG--RVFYFSVPPFAYADIARNINSSCRPHPGaWLRVVFEKPFGHD 184
Cdd:PTZ00309 128 KHISYIsgSYDEDEDFKRLNKLIERMEEAFQGPEKGgnRLFYLALPPSVFASVCEGIHRGCMSKNG-WVRVIVEKPFGRD 206
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 185 HLSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETVDAGGRASFYEEYGV 264
Cdd:PTZ00309 207 LESSEELSNQLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANR-VFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSYGI 285
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 265 IRDTLQNHLTEILTLVAMElPPNISSSAAVLQHKLQAFQALRGLQKSNAILGQYQAYSGQ----VRQELQKPDGfqSLTP 340
Cdd:PTZ00309 286 IRDVMQNHLLQILALLAME-KPVSLSAEDIRDEKVKVLKCIEPIKMEECVLGQYTASADGsipgYLEDEGVPKD--STTP 362
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 341 TFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRILFKNrayctqgerhwVPErsrclpqqIVFY---IGHGEL----- 412
Cdd:PTZ00309 363 TFAAAVLHINNDRWEGVPFILEAGKALEERYVEIRIQFKG-----------VDE--------FRPSgddTQRNELviraq 423
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 413 GHPAILVSKNLFKPSLPAQSWKGVQDQPGLHLFGrplsdyyayrpVREQDAYSTLLSHIFHCRKESFITTENLLASWVFW 492
Cdd:PTZ00309 424 PSEAMYLKITAKVPGLSNDLHQTELDLTYKTRYN-----------VRLPDAYERLILDALLGDSTNFVRKDELDVAWRIF 492
                        490       500
                 ....*....|....*....|
gi 157821675 493 TPLLDSL-SFEV-PRLYPGG 510
Cdd:PTZ00309 493 TPLLHQIdRGEVkPEPYPFG 512
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
562-797 1.20e-90

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 284.65  E-value: 1.20e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  562 ITAWPEELISKLANDIEAAAVQAVRRFGKFHLALSGGSSPIALFQQLATGhySFPWAYTHLWLVDERCVPLSDPDSNFQG 641
Cdd:TIGR01198   1 VFSNSAELAEALAERIATKLQTALAERGQFSLALSGGRSPIALLEALAAQ--PLDWSRIHLFLGDERYVPLDHADSNTGL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  642 LQAHLLQHVRVPYYNIHPMPVHLhqrlcAEEDQGAQTYASEISALVAN---SSFDLVLLGMGTDGHTASLFPQSPRGLDG 718
Cdd:TIGR01198  79 AREALLDRVAIPASNIHPMPTEL-----SDIEEAAELYEQELAAAFQPivfPVFDLLLLGMGPDGHTASLFPHTPALQET 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  719 DQLV-VLTESPFRPHQRMSLSLPLINRAKKVAVLVMGRTKREITTLVSRVGHEPKKWPISGVVPlSGQLVWYMDYEAFLG 797
Cdd:TIGR01198 154 ERLVtVLTKSPKPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALAVEAEPYPLPAAGVLH-SGKTLWLLDYAAARK 232
PRK05722 PRK05722
glucose-6-phosphate 1-dehydrogenase; Validated
33-380 3.14e-83

glucose-6-phosphate 1-dehydrogenase; Validated


Pssm-ID: 235579 [Multi-domain]  Cd Length: 495  Bit Score: 274.31  E-value: 3.14e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  33 IILLGATGDLAKKYLWQGLFQLYLDeagkGH---SFSFHGAALTA--PQQGQKLMDKALESLSCPKdlvpsRCDELKAQF 107
Cdd:PRK05722  12 LVIFGATGDLARRKLLPALYNLYKA----GLlpeDFRIIGVARRDwsDEDFREVVREALKEFARTP-----FDEEVWERF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 108 LQLSQYRQ--LKTVEDYQTLNKDIETQVQQDGLwEAGRVFYFSVPPFAYADIARNINSSCRPHPGAWLRVVFEKPFGHDH 185
Cdd:PRK05722  83 LSRLYYVSgdVTDPESYERLKELLEELDEERGT-GGNRVFYLATPPSLFGTICENLAAAGLNEGGGWRRVVIEKPFGHDL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 186 LSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNrkAL-DGLWNRHHVERVEIILKETVDAGGRASFYEEYGV 264
Cdd:PRK05722 162 ASARELNDQVGEVFKEEQIYRIDHYLGKETVQNLLALRFAN--ALfEPLWNRNYIDHVQITVAETVGVEGRGGYYDKSGA 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 265 IRDTLQNHLTEILTLVAMElPPNISSSAAVLQHKLQAFQALRGLQ----KSNAILGQYQAysGQV--------RQELQKP 332
Cdd:PRK05722 240 LRDMVQNHLLQLLALVAME-PPASLDADSIRDEKVKVLRALRPITpedvKENTVRGQYTA--GWIggkpvpgyREEEGVN 316
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 157821675 333 DgfQSLTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRILFKN 380
Cdd:PRK05722 317 P--DSTTETFVALKLEIDNWRWAGVPFYLRTGKRLPKKVTEIVIVFKP 362
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
564-788 3.61e-83

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 264.48  E-value: 3.61e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  564 AWPEELISKLANDIEAAAVQAVRRFGKFHLALSGGSSPIALFQQLATGHYSFPWAYTHLWLVDERCVPLSDPDSNFQGLQ 643
Cdd:pfam01182   1 PDAEALAQALAERLAEALEAALAERGRFTLALSGGSTPKPLYELLAAAPARLDWSRVHVFWGDERCVPPDDPDSNYGMAR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  644 AHLLQHVRVPYYNIHPMPVHLhqrlcAEEDQGAQTYASEISALVANSS---FDLVLLGMGTDGHTASLFPQSPRGLDGDQ 720
Cdd:pfam01182  81 EALLSHVPIPASNVHPIPASA-----ADPEEAAAAYEAELRELLPDLElpvFDLVLLGMGPDGHTASLFPGSPALEETDR 155
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  721 LVV-LTESPFRPHQRMSLSLPLINRAKKVAVLVMGRTKREIttlVSRV-GHEPKKWPISGVVPLSGQLVW 788
Cdd:pfam01182 156 LVVaVTDSPKPPPERITLTLPVLNAARRVWFLVTGAGKADA---LRRAlAGDPDPLPAALVRPGAGETVW 222
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
33-510 4.44e-83

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 273.43  E-value: 4.44e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675   33 IILLGATGDLAKKYLWQGLFQLY----LDEagkghSFSFHGAALTAPQQGQ--KLMDKALESlSCPKDLvpsrcDELKAQ 106
Cdd:TIGR00871   5 LVIFGASGDLARKKLFPALYRLFrnglLPP-----DFRIVGVARRDWSVEEfrKVVREAIIK-FETDEI-----DEQWDE 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  107 FLQLSQYR--QLKTVEDYQTLNKDIEtQVQQDGLWEAGRVFYFSVPPFAYADIARNINSSCRPHPGAWLRVVFEKPFGHD 184
Cdd:TIGR00871  74 FAQRLSYVsgDVDDDESYDSLAELLE-QLDKTYGTEGNRLFYLATPPSLFGTIIKQLKKHGLNEQGKWSRVVVEKPFGHD 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  185 HLSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETVDAGGRASFYEEYGV 264
Cdd:TIGR00871 153 LASAQELNKALRAVFKEDQIYRIDHYLGKETVQNLLVLRFANQ-IFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGA 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  265 IRDTLQNHLTEILTLVAMElPPNISSSAAVLQHKLQAFQALRGLQK--SNAILGQYQAysGQVRQElQKP-----DGF-- 335
Cdd:TIGR00871 232 LRDMVQNHLLQLLALVAME-PPVSFDADSIRDEKVKVLKALRPIDPddNNTVRGQYGA--GEIGGV-SVPgyleeEGVdk 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  336 QSLTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRILFKNrayctqgerhwVP-------ERSRCLPQQIVFYIG 408
Cdd:TIGR00871 308 DSNTETFAALKLEIDNWRWAGVPFYLRTGKRLPEKVTEIRIQFRD-----------VPsllfkanERDANPRNALVIRIQ 376
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  409 HGElghpAILVSKNLFKPSLPAQswkgVQDqpgLHLFGRPLSDYYAYRPvreqDAYSTLLSHIFHCRKESFITTENLLAS 488
Cdd:TIGR00871 377 PDE----GVYLKFNAKKPGLNFE----TRP---VKLDFSYASRFGELLP----EAYERLLLDALLGDHTLFARDDEVEEA 441
                         490       500
                  ....*....|....*....|....*
gi 157821675  489 WVFWTPLLDSL---SFEVPRLYPGG 510
Cdd:TIGR00871 442 WRIVTPILEAWaanKGPSPPNYPAG 466
PLN02539 PLN02539
glucose-6-phosphate 1-dehydrogenase
29-496 3.03e-81

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 178154 [Multi-domain]  Cd Length: 491  Bit Score: 268.90  E-value: 3.03e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  29 GHVSIILLGATGDLAKKYLWQGLFQLYLDEAGKGHSFSFHGAALTaPQQGQKLMDKALESLSCPKDlvpsRCDELKAQFL 108
Cdd:PLN02539  16 GCLSIIVLGASGDLAKKKTFPALFNLYRQGFLPPDEVHIFGYARS-KITDEELRDRIRGYLKDEKN----APAEAVSKFL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 109 QLSQYRQ--LKTVEDYQTLNKDI-ETQVQQDGLWEAG-RVFYFSVPPFAYADIARNINSSCRPHPGAWLRVVFEKPFGHD 184
Cdd:PLN02539  91 QLIKYVSgaYDSEEGFRRLDKEIsEHEISKNSAEGSSrRLFYLALPPSVYPPVCKMIKKCCMNKSGLWTRIVVEKPFGKD 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 185 HLSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRKALDgLWNRHHVERVEIILKETVDAGGRASFYEEYGV 264
Cdd:PLN02539 171 LESAEELSSQIGELFDESQLYRIDHYLGKELVQNLLVLRFANRFFLP-LWNRDNIANVQIVFREDFGTEGRGGYFDEYGI 249
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 265 IRDTLQNHLTEILTLVAMELPPNISSSaAVLQHKLQAFQALRGLQKSNAILGQYQAYsgqvRQELQKPDGfqSLTPTFAG 344
Cdd:PLN02539 250 IRDIIQNHLLQVLCLVAMEKPVSLKPE-HIRDEKVKVLQSVEPIKDEEVVLGQYEGY----RDDPTVPDD--SNTPTFAS 322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 345 VLVHIDNLRWEGVPFILMSGKALDERVGYVRILFKNrayctqgerhwVP-ERSRCLPQqivfyighgelghpailvSKNL 423
Cdd:PLN02539 323 VVLRINNERWEGVPFILKAGKALDSRKAEIRVQFKD-----------VPgDIFKCQKQ------------------GRNE 373
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 424 F----KPSlPAQSWKGVQDQPGLHLFGRP----LSDYYAYRPVREQDAYSTLLSHIFHCRKESFITTENLLASWVFWTPL 495
Cdd:PLN02539 374 FvirlQPS-EAMYMKLTVKQPGLEMSTVQseldLSYGQRYQDVVIPEAYERLILDTIRGDQQHFVRRDELKAAWEIFTPL 452

                 .
gi 157821675 496 L 496
Cdd:PLN02539 453 L 453
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
567-790 1.47e-78

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 252.10  E-value: 1.47e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 567 EELISKLANDIEAAAVQAVRRFGKFHLALSGGSSPIALFQQLATGhYSFPWAYTHLWLVDERCVPLSDPDSNFQGLQAHL 646
Cdd:cd01400    1 EALAEALADRIAEALAAAIAKRGRFSLALSGGSTPKPLYELLAAA-PALDWSKVHVFLGDERCVPPDDPDSNYRLAREAL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 647 LQHVRVPYYNIHPMPVHLHqrlcaeEDQGAQTYASEISALVANS-SFDLVLLGMGTDGHTASLFPQSPR-GLDGDQLVVL 724
Cdd:cd01400   80 LSHVAIPAANIHPIPTELG------PEDAAAAYEKELRALFGGVpPFDLVLLGMGPDGHTASLFPGHPAlLEETDRLVVA 153
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157821675 725 TE-SPFRPHQRMSLSLPLINRAKKVAVLVMGRTKREIttlVSRV--GHEPKKWPISGVVPLSGQLVWYM 790
Cdd:cd01400  154 VTdSPKPPPERITLTLPVLNNARRVVFLVTGAEKAEA---LKRAlaGPDPEELPAARVLPRPGEVLWFL 219
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
33-380 1.98e-78

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 261.55  E-value: 1.98e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  33 IILLGATGDLAKKYLWQGLFQLYLDeagkGH---SFSFHGAALTaPQQGQKLMDKALESLscpKDLVPSRCDELK-AQFL 108
Cdd:COG0364   12 LVIFGATGDLARRKLLPALYNLYRD----GLlpeGFRIIGVARR-DWSDEEFREEVREAL---EEFSRKPFDEEVwERFL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 109 QLSQYRQL--KTVEDYQTLNKDIEtqvQQDGLWEAG-RVFYFSVPPFAYADIARNINSSCRPHPGAWLRVVFEKPFGHDH 185
Cdd:COG0364   84 ERLHYVSGdfTDPEGYERLKELLE---ELDEERTPGnRVFYLATPPSLFGPICENLGAAGLATEGGWRRVVIEKPFGHDL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 186 LSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETVDAGGRASFYEEYGVI 265
Cdd:COG0364  161 ASARELNDELGRVFDESQIYRIDHYLGKETVQNLLALRFANA-LFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGAL 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 266 RDTLQNHLTEILTLVAMElPPNISSSAAVLQHKLQAFQALRGLQKS----NAILGQYQAysGQV--------RQElqkpD 333
Cdd:COG0364  240 RDMVQNHLLQLLCLVAME-PPASLDADAIRDEKVKVLRALRPITPEdvaeNTVRGQYTA--GWIggepvpgyREE----P 312
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 157821675 334 GF--QSLTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRILFKN 380
Cdd:COG0364  313 GVapDSTTETFVALKLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKP 361
PRK12853 PRK12853
glucose-6-phosphate dehydrogenase;
33-517 1.44e-71

glucose-6-phosphate dehydrogenase;


Pssm-ID: 237233 [Multi-domain]  Cd Length: 482  Bit Score: 242.50  E-value: 1.44e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  33 IILLGATGDLAKKYLWQGLFQLYLDEAgKGHSFSFHGAALTAPQQGQ--KLMDKALESLScPKDLVPSRCDelkaQFLQL 110
Cdd:PRK12853  11 LVIFGATGDLARRKLLPALYRLARAGL-LPEDLRIIGVGRDDWSDEQwrARVRESLRAFG-ADGFDDAVWD----RLAAR 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 111 SQYRQ--LKTVEDYQTLNKDIETQVQqdglweagRVFYFSVPPFAYADIARNINSS-CRPhpgAWLRVVFEKPFGHDHLS 187
Cdd:PRK12853  85 LSYVQgdVTDPADYARLAEALGPGGN--------PVFYLAVPPSLFAPVVENLGAAgLLP---EGRRVVLEKPFGHDLAS 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 188 AQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETVDAGGRASFYEEYGVIRD 267
Cdd:PRK12853 154 ARALNATLAKVFDEDQIYRIDHFLGKETVQNLLALRFANA-LLEPLWNRNHIDHVQITVAETLGVEGRGGFYDATGALRD 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 268 TLQNHLTEILTLVAMElPPNISSSAAVLQHKLQAFQALRGLQKSNAIL--GQYQAysGQV--------RQELQKPDGfqS 337
Cdd:PRK12853 233 MVQNHLLQLLALVAME-PPASFDADAVRDEKAKVLRAIRPLDPDDVHTvrGQYTA--GTVggepvpgyREEPGVDPD--S 307
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 338 LTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRILFKNRAYCTQGERHwvpersRCLPQQIVFYIGHGELGHPAI 417
Cdd:PRK12853 308 RTETFVALKLEIDNWRWAGVPFYLRTGKRLAERRTEIVITFKPVPHALFRGTG------VEPPNRLVIRLQPDEGISLEL 381
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 418 LVSknlfkpslpaqswkgvqdQPGLHLFGRPLSDYYAYR-PVREQDAYSTLLSHIFHCRKESFITTENLLASWVFWTPLL 496
Cdd:PRK12853 382 NVK------------------RPGPGMRLRPVELDADYAdDERPLEAYERLLLDVLRGDPTLFVRADEVEAAWRIVDPVL 443
                        490       500
                 ....*....|....*....|....*..
gi 157821675 497 D--SLSFEVPRLYPGG----AENDHLL 517
Cdd:PRK12853 444 DawAADPVPPHEYPAGswgpAAADALL 470
PLN02640 PLN02640
glucose-6-phosphate 1-dehydrogenase
23-511 3.90e-70

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215344 [Multi-domain]  Cd Length: 573  Bit Score: 241.46  E-value: 3.90e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  23 QAQEFRGHVSIILLGATGDLAKKYLWQGLFQLYLdEAGKGHSFSFHGAALTAPQQgQKLMDKALESLSCPKDlVPSRCDE 102
Cdd:PLN02640  81 HAEKGESTLSITVVGASGDLAKKKIFPALFALFY-EDWLPENFTVFGYARTKLTD-EELRDMISSTLTCRID-QRENCGD 157
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 103 LKAQFLQLSQYR--QLKTVEDYQTLNKDIETQvqqdglwEAG----RVFYFSVPPFAYADIARNINSSCRPHPGaWLRVV 176
Cdd:PLN02640 158 KMDQFLKRCFYHsgQYDSEEDFAELNKKLKEK-------EAGklsnRLFYLSIPPNIFVDVVRCASLRASSENG-WTRVI 229
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 177 FEKPFGHDHLSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETVDAGGRA 256
Cdd:PLN02640 230 VEKPFGRDSESSGELTRCLKQYLTEEQIFRIDHYLGKELVENLSVLRFSNL-VFEPLWSRNYIRNVQLIFSEDFGTEGRG 308
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 257 SFYEEYGVIRDTLQNHLTEILTLVAMELPPNISSSaAVLQHKLQAFQALRGLQKSNAILGQYQAYSGQVR------QELQ 330
Cdd:PLN02640 309 GYFDNYGIIRDIMQNHLLQILALFAMETPVSLDAE-DIRNEKVKVLRSMKPLQLEDVIVGQYKGHSKGGKsypaytDDPT 387
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 331 KPDGfqSLTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRILFKN-------RAYCTQGERhwvpersrcLPQQI 403
Cdd:PLN02640 388 VPKH--SLTPTFAAAALFINNARWDGVPFLMKAGKALHTRRAEIRVQFRHvpgnlykRNFGTDLDK---------ATNEL 456
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 404 VFYIGHGElghpAILVSKNLFKPSLpaqswkgvqdqpGLHLFGRPLSDYYAYRPVRE-QDAYSTLLSHIFHCRKESFITT 482
Cdd:PLN02640 457 VLRVQPDE----AIYLKINNKVPGL------------GMRLDRSDLNLLYRARYPREiPDAYERLLLDAIEGERRLFIRS 520
                        490       500       510
                 ....*....|....*....|....*....|.
gi 157821675 483 ENLLASWVFWTPLLDSLSFE--VPRLYPGGA 511
Cdd:PLN02640 521 DELDAAWALFTPLLKELEEKkiIPELYPYGS 551
PLN02333 PLN02333
glucose-6-phosphate 1-dehydrogenase
31-511 1.51e-69

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215191 [Multi-domain]  Cd Length: 604  Bit Score: 240.65  E-value: 1.51e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  31 VSIILLGATGDLAKKYLWQGLFQLYLDEAGKGHsFSFHGAALTapqqgqKLMDKAL-----ESLSCPKDlVPSRCDELKA 105
Cdd:PLN02333 118 VSITVVGASGDLAKKKIFPALFALYYEGCLPEH-FTIFGYARS------KMTDAELrnmvsKTLTCRID-KRENCGEKME 189
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 106 QFLQLSQYR--QLKTVEDYQTLNKDIETQvqqdglwEAGRV----FYFSVPPFAYADIARNINSSCRPHPGaWLRVVFEK 179
Cdd:PLN02333 190 EFLKRCFYHsgQYDSQEHFAELDKKLKEH-------EGGRVsnrlFYLSIPPNIFVDAVKCASSSASSVNG-WTRVIVEK 261
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 180 PFGHDHLSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETVDAGGRASFY 259
Cdd:PLN02333 262 PFGRDSESSAALTKSLKQYLEEDQIFRIDHYLGKELVENLSVLRFSNL-IFEPLWSRQYIRNVQFIFSEDFGTEGRGGYF 340
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 260 EEYGVIRDTLQNHLTEILTLVAMELPPNISSSaAVLQHKLQAFQALRGLQKSNAILGQYQAYS-GQVR-----QELQKPD 333
Cdd:PLN02333 341 DNYGIIRDIMQNHLLQILALFAMETPVSLDAE-DIRNEKVKVLRSMRPIQLEDVVIGQYKSHTkGGVTypaytDDKTVPK 419
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 334 GfqSLTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRILFK-------NRAYCTQGERhwvpersrcLPQQIVFY 406
Cdd:PLN02333 420 G--SLTPTFAAAALFIDNARWDGVPFLMKAGKALHTKSAEIRVQFRhvpgnlyNRNFGTDLDQ---------ATNELVIR 488
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 407 IGHGElghpAILVSKNLFKPSLpaqswkGVQ-DQPGLHLfgrplsdYYAYRPVRE-QDAYSTLLSHIFHCRKESFITTEN 484
Cdd:PLN02333 489 VQPDE----AIYLKINNKVPGL------GMRlDRSNLNL-------LYAARYSKEiPDAYERLLLDAIEGERRLFIRSDE 551
                        490       500
                 ....*....|....*....|....*....
gi 157821675 485 LLASWVFWTPLLDSLSFE--VPRLYPGGA 511
Cdd:PLN02333 552 LDAAWALFTPLLKELEEKkiIPEYYPYGS 580
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
233-518 1.13e-64

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 217.69  E-value: 1.13e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  233 LWNRHHVERVEIILKETVDAGGRASFYEEYGVIRDTLQNHLTEILTLVAMElPPNISSSAAVLQHKLQAFQALRGLQKS- 311
Cdd:pfam02781  13 LWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAME-PPVSFDAEDIRDEKVKVLRSLRPITPEd 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  312 ---NAILGQYQA--YSGQV----RQELQKPDGfqSLTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRILFKNra 382
Cdd:pfam02781  92 vedNVVRGQYGAgwIGGEPvpgyREEEGVPPD--SRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVTEIRIQFKD-- 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  383 yctqgerhwVP-----ERSRCLPQQIVFYIGHGElghpAILVSKNLFKpslpaqswkgvqdqPGLHLFGRPLS---DYYA 454
Cdd:pfam02781 168 ---------VPhnlfrDPGTLPPNELVIRIQPDE----GIYLKFNAKV--------------PGLGMRLRPVEldfSYSD 220
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157821675  455 YRPVREQDAYSTLLSHIFHCRKESFITTENLLASWVFWTPLLDSLSFEVPRLYPGG----AENDHLLD 518
Cdd:pfam02781 221 RFGERIPEAYERLLLDVMRGDQTLFVRSDEVEAAWRIVDPILEAWDEEKPPPYPAGswgpKAADELLA 288
PRK12854 PRK12854
glucose-6-phosphate 1-dehydrogenase; Provisional
33-510 2.54e-64

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 237234 [Multi-domain]  Cd Length: 484  Bit Score: 222.99  E-value: 2.54e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  33 IILLGATGDLAKKYLWQGLFQLYLDE--------AGKGHSfsfhgaALTAPQQGQKLMDKALESLSCPKDlvpsrcDELK 104
Cdd:PRK12854  14 FVLFGATGDLAKRKLLPGLFHLARAGllppdwriVGTGRG------DVSAEAFREHARDALDEFGARKLD------DGEW 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 105 AQFLQLSQYRQLK-TVEDYQTLnKDIETQVQQDGLWEAGRVFYFSVPPFAYADIARNInsscrphPGAWL----RVVFEK 179
Cdd:PRK12854  82 ARFAKRLRYVPGGfLSAGPGAL-AAAVAAARAELGGDARLVHYLAVPPSAFLDVTRAL-------GEAGLaegsRVVMEK 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 180 PFGHDHLSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETVDAGGRASFY 259
Cdd:PRK12854 154 PFGTDLASAEALNAAVHEVFDESQIFRIDHFLGKEAAQNILAFRFANG-LFEPIWNREFIDHVQIDVPETLGVDTRAAFY 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 260 EEYGVIRDTLQNHLTEILTLVAMElPPNISSSAAVLQHKLQAFQALRGLQKSNAILGQYQAYsgqvRQElqkpDGF--QS 337
Cdd:PRK12854 233 DATGAYRDMVVTHLFQVLAFVAME-PPTALEPDAISEEKNKVFRSMRPLDPAEVVRGQYSGY----RDE----PGVapDS 303
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 338 LTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRILFKNrayctqgerhwvPERSrclpqqiVFYIGHGELGHPAI 417
Cdd:PRK12854 304 TTETFVALKVWIDNWRWAGVPFYLRTGKRMAEGQRIISIAFRE------------PPYS-------MFPAGSVGAQGPDH 364
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 418 LvSKNLFKPSLPAQSWKGVQDQPGLHLfgRPLSDYYAYRPVREQ----DAYSTLLSHIFHCRKESFITTENLLASWVFWT 493
Cdd:PRK12854 365 L-TFDLADNSKVSLSFYGKRPGPGMRL--DKLSLQFSLKDTGPKgdvlEAYERLILDALRGDHTLFTTADGIESLWEVSQ 441
                        490
                 ....*....|....*..
gi 157821675 494 PLLDSLSfeVPRLYPGG 510
Cdd:PRK12854 442 PLLEDPP--PVKPYAPG 456
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
566-794 4.14e-55

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 189.99  E-value: 4.14e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 566 PEELISKLANDIEAAAVQAVRRFGKFHLALSGGSSPIALFQQLATGHYS--FPWAYTHLWLVDERC-VPLSDPDSNFQGL 642
Cdd:COG0363   10 AEELAAAAAERAAERIAEAIAEKGRAVLGLAGGSTPLGLYEELARLHKEggLDWSRVHVFNLDEYVgLPPDHPQSNRRFM 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 643 QAHLLQHVRVPYYNIHPMPVHLhqrlcAEEDQGAQTYASEISALvanSSFDLVLLGMGTDGHTASLFPQSPRGLDGDQLV 722
Cdd:COG0363   90 REALLDHVDIPPENIHIPDGEA-----EDPEAAAARYEALIAEA---GGIDLQLLGIGEDGHIAFNFPGSPFLSETDRVV 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 723 VLTESPFR------------PHQRMSLSLPLINRAKKVAVLVMGRTKREIttlVSRV--GHEPKKWPISGVVPLSgQLVW 788
Cdd:COG0363  162 TLDESTRQanarffgsipkvPPQAITLGIPTIMKAREILLLATGENKAEA---VAAAleGPVTEEVPASILQGHP-NVTW 237

                 ....*.
gi 157821675 789 YMDYEA 794
Cdd:COG0363  238 FLDEAA 243
G6PD_N pfam00479
Glucose-6-phosphate dehydrogenase, NAD binding domain;
34-216 2.93e-41

Glucose-6-phosphate dehydrogenase, NAD binding domain;


Pssm-ID: 459827 [Multi-domain]  Cd Length: 178  Bit Score: 149.11  E-value: 2.93e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675   34 ILLGATGDLAKKYLWQGLFQLYLDeagkGH---SFSFHGAALTaPQQGQKLMDKALESLSCPKDlvpsRCDELKAQFLQL 110
Cdd:pfam00479   1 VIFGATGDLAKRKLFPALYNLYRD----GLlpeGFRIIGVARR-DLSDEEFRERVREALKEFKE----LDEEKWDRFLER 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675  111 SQYRQ--LKTVEDYQTLNKDIEtqvQQDGLWEAGRVFYFSVPPFAYADIARNINSSCRPHPGAWLRVVFEKPFGHDHLSA 188
Cdd:pfam00479  72 LHYVSgdFDDPESYEKLKERLE---EHEDETRGNRLFYLAVPPSLFGPIAENLGRAGLSEEGGWRRVVIEKPFGHDLESA 148
                         170       180
                  ....*....|....*....|....*...
gi 157821675  189 QQLASELGSFFQEEEMYRVDHYLGKQAV 216
Cdd:pfam00479 149 RELNDQLAKVFKEEQIYRIDHYLGKETV 176
PLN02360 PLN02360
probable 6-phosphogluconolactonase
567-794 3.17e-30

probable 6-phosphogluconolactonase


Pssm-ID: 166001 [Multi-domain]  Cd Length: 268  Bit Score: 120.35  E-value: 3.17e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 567 EELISKLANDIEAAAVQAVRRFGKFHLALSGGSSpIALFQQLATGHY--SFPWAYTHLWLVDERCVPLSDPDSNFQGLQA 644
Cdd:PLN02360  20 DELSTDLAEYIAELSEASVKERGVFAIALSGGSL-ISFMGKLCEAPYnkTVDWAKWYIFWADERVVAKNHADSNYKLAKD 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 645 HLLQHVRVPYYNIHPmpvhLHQRLCAEEdqGAQTYASEISALVANSS-----------FDLVLLGMGTDGHTASLFPQSP 713
Cdd:PLN02360  99 GLLSKVPVVPSHVYS----INDTVTAEE--AATDYEFAIRQLVKTRTigvsdisdcpkFDLILLGMGSDGHVASLFPNHP 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 714 R-GLDGDQLVVLTESPFRPHQRMSLSLPLINRAKKVAVLVMGRTKREITTL-VSRVGHEP--KKWPISGVVPLSGQLVWY 789
Cdd:PLN02360 173 AlEEKDDWVTFITDSPKPPPERITFTLPVINSASNVAVVATGESKANAVHLaIDDVTEGPdaPSLPARMVQPTKGKLVWF 252

                 ....*
gi 157821675 790 MDYEA 794
Cdd:PLN02360 253 LDKPA 257
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
578-777 2.02e-13

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 70.59  E-value: 2.02e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 578 EAAA---VQAVRRFGKFHLALSGGSSPIALFQQLATGHYS--FPWAYTHLWLVDERcVPLS--DPDSNFQGLQAHLLQHV 650
Cdd:cd01399    5 EAAAeliAELIREKPPAVLGLATGSTPLGVYEELIELHKEggLSFSNVTTFNLDEY-VGLPpdHPQSYHYFMRENLFDHI 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 651 RVPYYNIHPMPVhlhqrLCAEEDQGAQTYASEISALvanSSFDLVLLGMGTDGHTAslFPQSPRGLDGD-QLVVLTES-- 727
Cdd:cd01399   84 DIKPENIHIPDG-----NAADLEAECRRYEALIAEA---GGIDLQLLGIGENGHIG--FNEPGSSLDSRtRVVTLDEStr 153
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157821675 728 -----PFR-----PHQRMSLSLPLINRAKKVAVLVMGRTKREIttlVSRVGHEP--KKWPIS 777
Cdd:cd01399  154 qanarFFDgdedvPTQAITMGIGTIMKAKEILLLATGEGKAEA---VKKALEGPvtEECPAS 212
SugarP_isomerase cd00458
SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate ...
590-705 6.40e-08

SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium, the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate. 6PGL converts 6-phosphoglucono-1,5-lactone to 6-phosphogluconate, the second step of the oxidative phase of the pentose phosphate pathway.


Pssm-ID: 238258  Cd Length: 169  Bit Score: 53.13  E-value: 6.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 590 KFHLALSGGSSPIALFQQLATGHYSFPWAYTHLWLVDERCVPLSDPDSNFQGLQAHLLQHVRVPYYNIHPMPVHLhqrlc 669
Cdd:cd00458   21 DMVIGLGTGSTPAYFYKLLGEKLKRGEISDIVGFPTDERYVPLDSDQSNFRQAKLLAFEHDIIPASNVHYVDTSL----- 95
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 157821675 670 AEEDQGAQTYASEISALvanSSFDLVLLGMGTDGHT 705
Cdd:cd00458   96 PIEKACEKYEREILDQV---DAIDLAVDGAGYRAGT 128
PTZ00285 PTZ00285
glucosamine-6-phosphate isomerase; Provisional
591-777 2.83e-07

glucosamine-6-phosphate isomerase; Provisional


Pssm-ID: 140308  Cd Length: 253  Bit Score: 52.45  E-value: 2.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 591 FHLALSGGSSPIALFQQLATGH----YSFPWAYThlWLVDERC-VPLSDPDSNFQGLQAHLLQHVrvpyyNIHPMPVHLH 665
Cdd:PTZ00285  35 FVLGLPTGSTPLPTYQELIRAYregrVSFSNVVT--FNMDEYVgLPRDHPQSYHYFMKENFFDHV-----DIKEENRHIL 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 666 QRLCAEEDQGAQTYASEISALvanSSFDLVLLGMGTDGHTASLFPQSPRGlDGDQLVVLTESPFR-------------PH 732
Cdd:PTZ00285 108 NGTAPDLEEECRRYEEKIRAV---GGIDLFLAGIGTDGHIAFNEPGSSLD-SRTRVKSLNQETIDanarffgndiskvPT 183
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 157821675 733 QRMSLSLPLINRAKKVAVLVMGRTKREITT--LVSRVGHepkKWPIS 777
Cdd:PTZ00285 184 MALTVGIRTIMEAREVLLLATGASKAIAVArcVEGGVTH---MCPAS 227
PRK02122 PRK02122
glucosamine-6-phosphate deaminase-like protein; Validated
566-760 8.45e-06

glucosamine-6-phosphate deaminase-like protein; Validated


Pssm-ID: 235005 [Multi-domain]  Cd Length: 652  Bit Score: 49.26  E-value: 8.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 566 PEELISKLANDIeAAAVQAVRRFGKFH-LALSGGSSPIALFQQLATGH----YSFPWAYThlWLVDERcVPLS--DPDSN 638
Cdd:PRK02122  36 SEEASRAVAQEI-ATLIRERQAEGKPCvLGLATGSSPIGVYAELIRMHreegLSFKNVIT--FNLDEY-YPMQpdSLQSY 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 639 FQGLQAHLLQHVRVPYYNIHPMPVHLHQrlcAEEDQGAQTYASEISALvanSSFDLVLLGMGTDGHTASLFPQSPRGlDG 718
Cdd:PRK02122 112 HRFMKENLFDHVDIPPENIHIPDGTIPK---EEIDEYCRDYEEKIEAA---GGIDFQLLGIGRTGHIGFNEPGSGRN-SR 184
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 157821675 719 DQLVVLTESPFR------------PHQRMSLSLPLINRAKKVAVLVMGRTKREI 760
Cdd:PRK02122 185 TRLVTLDHITRRdaasdffgeenvPRKAITMGVGTILKARRIVLLAWGEHKAPI 238
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
574-777 2.66e-05

glucosamine-6-phosphate deaminase; Provisional


Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 46.75  E-value: 2.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 574 ANDIEAAAVQAVRRFGK-FHLALSGGSSPIALFQQLATGHYS--FPWAYTHLWLVDE-RCVPLSDPDS--NFqgLQAHLL 647
Cdd:PRK00443  17 ARHIANRINAFLPTKERpFVLGLATGSSPLETYKALIELHKAgkVDFSRVTTFNLDEyVGLPADHPESyrYF--MRENFF 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 648 QHVrvpyyNIHPMPVHLHQRLCAEEDQGAQTYASEIsalVANSSFDLVLLGMGTDGHTAslF--PQSPrgLDGDQLVV-L 724
Cdd:PRK00443  95 DHV-----DIPPENINLLNGNAPDPEAECRRYEEKI---KSAGGIDLQILGIGENGHIA--FnePGSS--FASRTRIKtL 162
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157821675 725 TESPFR-------------PHQRMSLSLPLINRAKKVAVLVMGRTKREIT--TLVSRVGHEpkkWPIS 777
Cdd:PRK00443 163 TEDTRIansrffdgdieqvPKYALTVGVGTILDAKEIMLLAPGHNKAEAVkaAVEGPVNHM---WPAS 227
PRK12358 PRK12358
glucosamine-6-phosphate deaminase;
590-704 2.71e-03

glucosamine-6-phosphate deaminase;


Pssm-ID: 183470  Cd Length: 239  Bit Score: 40.12  E-value: 2.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157821675 590 KFHLALSGGSSPIALFQQLATGHYSFPW-AYTHLWLVDErcVPLSDPDS---NFQGLQAHLLQHVRVPYYNIHPMPVhlh 665
Cdd:PRK12358  29 RVNLAITAGSTPKGMYEYLITLVKGKAWyDNVHYYNFDE--IPFRGKEGegvTITNLRNLFFTPAGIKEENIHKLTI--- 103
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 157821675 666 qrlcaeedqgaQTYASEISALVANSSFDLVLLGMGTDGH 704
Cdd:PRK12358 104 -----------DNYREHDQKLARDGGLDLVVLGLGADGH 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH