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Conserved domains on  [gi|157823237|ref|NP_001099888|]
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interleukin-7 receptor subunit alpha precursor [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3_7 pfam18447
Fibronectin type III domain; This domain is found in Interleukin-7 receptor subunit alpha ...
 32-127 6.70e-53

Fibronectin type III domain; This domain is found in Interleukin-7 receptor subunit alpha (IL-7Ralpha), which together IL-7 form a complex crucial to several signalling cascades leading to the development and homeostasis of T and B cells. IL-7Ralpha carries a 219 residue ectodomain on the N-terminal region which is crucial for T and B-cell development. Mutations in the IL-7Ralpha ectodomain inhibits T and B cell development, resulting in patients with a form of severe combined immunodeficiency (SCID). The ectodomain folds into two fibronectin type III (FNIII) domains connected by a 310-helical linker. This entry comprises the first of the two FNIII domains, D1 while D2 domain is pfam00041. In the D1 domain of IL-7Ralpha, a disulfide bond (C22R-C37R) conserved among cytokine receptor class I (CRH I) family members bridges two beta strands.


:

Pssm-ID: 465772  Cd Length: 97  Bit Score: 172.55  E-value: 6.70e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823237   32 DAEPDDHSFWCHSQLEVDGNQHSLTCAFNDPDIKTTNLEFQICGAL-LGIDCLTLNKLREMYFIKTSKFLLIGNSSVCVK 110
Cdd:pfam18447   1 DAEPDDYSFSCFSQLEVDGSQHSLTCAFTDPDLNSTNLEFEICGALdLEVKCLNMEKLEDVYFIKTKKFLLIGNSDICVK 80

                          90
                  ....*....|....*..
gi 157823237  111 LGKMDVICKILDISTIV 127
Cdd:pfam18447  81 LEMKRKTCKSLKITKIV 97
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 131-219 2.11e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam00041:

Pssm-ID: 473895 [Multi-domain]  Cd Length: 85  Bit Score: 40.09  E-value: 2.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823237  131 APSNLKVVYRKEaNDFLVTFNTSHSTKKYVTalKHDVAYRPERGESNWTHVYLFHTRTTILQRKLQPKAVYEIKVRSIPN 210
Cdd:pfam00041   2 APSNLTVTDVTS-TSLTVSWTPPPDGNGPIT--GYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                  ....*....
gi 157823237  211 HEYfkGFWS 219
Cdd:pfam00041  79 GGE--GPPS 85
 
Name Accession Description Interval E-value
FN3_7 pfam18447
Fibronectin type III domain; This domain is found in Interleukin-7 receptor subunit alpha ...
 32-127 6.70e-53

Fibronectin type III domain; This domain is found in Interleukin-7 receptor subunit alpha (IL-7Ralpha), which together IL-7 form a complex crucial to several signalling cascades leading to the development and homeostasis of T and B cells. IL-7Ralpha carries a 219 residue ectodomain on the N-terminal region which is crucial for T and B-cell development. Mutations in the IL-7Ralpha ectodomain inhibits T and B cell development, resulting in patients with a form of severe combined immunodeficiency (SCID). The ectodomain folds into two fibronectin type III (FNIII) domains connected by a 310-helical linker. This entry comprises the first of the two FNIII domains, D1 while D2 domain is pfam00041. In the D1 domain of IL-7Ralpha, a disulfide bond (C22R-C37R) conserved among cytokine receptor class I (CRH I) family members bridges two beta strands.


Pssm-ID: 465772  Cd Length: 97  Bit Score: 172.55  E-value: 6.70e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823237   32 DAEPDDHSFWCHSQLEVDGNQHSLTCAFNDPDIKTTNLEFQICGAL-LGIDCLTLNKLREMYFIKTSKFLLIGNSSVCVK 110
Cdd:pfam18447   1 DAEPDDYSFSCFSQLEVDGSQHSLTCAFTDPDLNSTNLEFEICGALdLEVKCLNMEKLEDVYFIKTKKFLLIGNSDICVK 80

                          90
                  ....*....|....*..
gi 157823237  111 LGKMDVICKILDISTIV 127
Cdd:pfam18447  81 LEMKRKTCKSLKITKIV 97
fn3 pfam00041
Fibronectin type III domain;
131-219 2.11e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.09  E-value: 2.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823237  131 APSNLKVVYRKEaNDFLVTFNTSHSTKKYVTalKHDVAYRPERGESNWTHVYLFHTRTTILQRKLQPKAVYEIKVRSIPN 210
Cdd:pfam00041   2 APSNLTVTDVTS-TSLTVSWTPPPDGNGPIT--GYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                  ....*....
gi 157823237  211 HEYfkGFWS 219
Cdd:pfam00041  79 GGE--GPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 129-229 3.90e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 39.40  E-value: 3.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823237 129 PEAPSNLKVVYRkEANDFLVTFNTSHSTKKYVTALKhdVAYRPErGESNWTHV-YLFHTRTTILQRKLQPKAVYEIKVRS 207
Cdd:cd00063    1 PSPPTNLRVTDV-TSTSVTLSWTPPEDDGGPITGYV--VEYREK-GSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRA 76

                         90       100
                 ....*....|....*....|..
gi 157823237 208 ipnheYFKGFWSEWSPSSTFET 229
Cdd:cd00063   77 -----VNGGGESPPSESVTVTT 93
 
Name Accession Description Interval E-value
FN3_7 pfam18447
Fibronectin type III domain; This domain is found in Interleukin-7 receptor subunit alpha ...
 32-127 6.70e-53

Fibronectin type III domain; This domain is found in Interleukin-7 receptor subunit alpha (IL-7Ralpha), which together IL-7 form a complex crucial to several signalling cascades leading to the development and homeostasis of T and B cells. IL-7Ralpha carries a 219 residue ectodomain on the N-terminal region which is crucial for T and B-cell development. Mutations in the IL-7Ralpha ectodomain inhibits T and B cell development, resulting in patients with a form of severe combined immunodeficiency (SCID). The ectodomain folds into two fibronectin type III (FNIII) domains connected by a 310-helical linker. This entry comprises the first of the two FNIII domains, D1 while D2 domain is pfam00041. In the D1 domain of IL-7Ralpha, a disulfide bond (C22R-C37R) conserved among cytokine receptor class I (CRH I) family members bridges two beta strands.


Pssm-ID: 465772  Cd Length: 97  Bit Score: 172.55  E-value: 6.70e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823237   32 DAEPDDHSFWCHSQLEVDGNQHSLTCAFNDPDIKTTNLEFQICGAL-LGIDCLTLNKLREMYFIKTSKFLLIGNSSVCVK 110
Cdd:pfam18447   1 DAEPDDYSFSCFSQLEVDGSQHSLTCAFTDPDLNSTNLEFEICGALdLEVKCLNMEKLEDVYFIKTKKFLLIGNSDICVK 80

                          90
                  ....*....|....*..
gi 157823237  111 LGKMDVICKILDISTIV 127
Cdd:pfam18447  81 LEMKRKTCKSLKITKIV 97
fn3 pfam00041
Fibronectin type III domain;
131-219 2.11e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.09  E-value: 2.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823237  131 APSNLKVVYRKEaNDFLVTFNTSHSTKKYVTalKHDVAYRPERGESNWTHVYLFHTRTTILQRKLQPKAVYEIKVRSIPN 210
Cdd:pfam00041   2 APSNLTVTDVTS-TSLTVSWTPPPDGNGPIT--GYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                  ....*....
gi 157823237  211 HEYfkGFWS 219
Cdd:pfam00041  79 GGE--GPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 129-229 3.90e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 39.40  E-value: 3.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157823237 129 PEAPSNLKVVYRkEANDFLVTFNTSHSTKKYVTALKhdVAYRPErGESNWTHV-YLFHTRTTILQRKLQPKAVYEIKVRS 207
Cdd:cd00063    1 PSPPTNLRVTDV-TSTSVTLSWTPPEDDGGPITGYV--VEYREK-GSGDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRA 76

                         90       100
                 ....*....|....*....|..
gi 157823237 208 ipnheYFKGFWSEWSPSSTFET 229
Cdd:cd00063   77 -----VNGGGESPPSESVTVTT 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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