NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|157817803|ref|NP_001099620|]
View 

protein sprouty homolog 4 [Rattus norvegicus]

Protein Classification

sprouty family protein( domain architecture ID 10525175)

sprouty family protein may be an inhibitor of the Ras/mitogen-activated protein kinase (MAPK) cascade, a pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Sprouty pfam05210
Sprouty protein (Spry); This family consists of eukaryotic Sprouty protein homologs. Sprouty ...
 165-267 2.27e-24

Sprouty protein (Spry); This family consists of eukaryotic Sprouty protein homologs. Sprouty proteins have been revealed as inhibitors of the Ras/mitogen-activated protein kinase (MAPK) cascade, a pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases. The sprouty gene has found to be expressed in the the brain, cochlea, nasal organs, teeth, salivary gland, lungs, digestive tract, kidneys and limb buds in mice.


:

Pssm-ID: 461589  Cd Length: 101  Bit Score: 94.32  E-value: 2.27e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817803  165 KCKCKEC----ASPRTLPSCwvcnqeclCSAQTLVNYSTCMCLVQGIFYHCTnEDDEGSCADHPCS-CSGSNCCARWSFM 239
Cdd:pfam05210   1 RCRCVYCqelfTEPRNLPGS--------CSAESCIDYVSCMCCAKGLFYHCM-SDAEGDDSCDPCScCSPHRCCKRWLAL 71

                          90       100
                  ....*....|....*....|....*...
gi 157817803  240 GALSLVLPCLLCYLPATGCVKLAQRGYD 267
Cdd:pfam05210  72 ALLSLLLPCLCCYPPLRACHKCCVACGC 99
 
Name Accession Description Interval E-value
Sprouty pfam05210
Sprouty protein (Spry); This family consists of eukaryotic Sprouty protein homologs. Sprouty ...
 165-267 2.27e-24

Sprouty protein (Spry); This family consists of eukaryotic Sprouty protein homologs. Sprouty proteins have been revealed as inhibitors of the Ras/mitogen-activated protein kinase (MAPK) cascade, a pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases. The sprouty gene has found to be expressed in the the brain, cochlea, nasal organs, teeth, salivary gland, lungs, digestive tract, kidneys and limb buds in mice.


Pssm-ID: 461589  Cd Length: 101  Bit Score: 94.32  E-value: 2.27e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817803  165 KCKCKEC----ASPRTLPSCwvcnqeclCSAQTLVNYSTCMCLVQGIFYHCTnEDDEGSCADHPCS-CSGSNCCARWSFM 239
Cdd:pfam05210   1 RCRCVYCqelfTEPRNLPGS--------CSAESCIDYVSCMCCAKGLFYHCM-SDAEGDDSCDPCScCSPHRCCKRWLAL 71

                          90       100
                  ....*....|....*....|....*...
gi 157817803  240 GALSLVLPCLLCYLPATGCVKLAQRGYD 267
Cdd:pfam05210  72 ALLSLLLPCLCCYPPLRACHKCCVACGC 99
 
Name Accession Description Interval E-value
Sprouty pfam05210
Sprouty protein (Spry); This family consists of eukaryotic Sprouty protein homologs. Sprouty ...
 165-267 2.27e-24

Sprouty protein (Spry); This family consists of eukaryotic Sprouty protein homologs. Sprouty proteins have been revealed as inhibitors of the Ras/mitogen-activated protein kinase (MAPK) cascade, a pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases. The sprouty gene has found to be expressed in the the brain, cochlea, nasal organs, teeth, salivary gland, lungs, digestive tract, kidneys and limb buds in mice.


Pssm-ID: 461589  Cd Length: 101  Bit Score: 94.32  E-value: 2.27e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157817803  165 KCKCKEC----ASPRTLPSCwvcnqeclCSAQTLVNYSTCMCLVQGIFYHCTnEDDEGSCADHPCS-CSGSNCCARWSFM 239
Cdd:pfam05210   1 RCRCVYCqelfTEPRNLPGS--------CSAESCIDYVSCMCCAKGLFYHCM-SDAEGDDSCDPCScCSPHRCCKRWLAL 71

                          90       100
                  ....*....|....*....|....*...
gi 157817803  240 GALSLVLPCLLCYLPATGCVKLAQRGYD 267
Cdd:pfam05210  72 ALLSLLLPCLCCYPPLRACHKCCVACGC 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH