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Conserved domains on  [gi|158187546|ref|NP_001099603|]
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dymeclin [Rattus norvegicus]

Protein Classification

dymeclin( domain architecture ID 10560863)

dymeclin is necessary for correct organization of Golgi apparatus

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Dymeclin pfam09742
Dyggve-Melchior-Clausen syndrome protein; Dymeclin (Dyggve-Melchior-Clausen syndrome protein) ...
1-646 0e+00

Dyggve-Melchior-Clausen syndrome protein; Dymeclin (Dyggve-Melchior-Clausen syndrome protein) contains a large number of leucine and isoleucine residues and a total of 17 repeated dileucine motifs. It is characteriztically about 700 residues long and present in plants and animals. Mutations in the gene coding for this protein in humans give rise to the disorder Dyggve-Melchior-Clausen syndrome (DMC, MIM 223800) which is an autosomal-recessive disorder characterized by the association of a spondylo-epi-metaphyseal dysplasia and mental retardation. DYM transcripts are widely expressed throughout human development and Dymeclin is not an integral membrane protein of the ER, but rather a peripheral membrane protein dynamically associated with the Golgi apparatus.


:

Pssm-ID: 462873  Cd Length: 645  Bit Score: 733.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158187546    1 MGSNSSKISdlPKNEYLKRLSGPEAISENDPFWNQLFSFSFSAPTSSTELKLLEEATISVCKSLVENNPRTGNLAALTKV 80
Cdd:pfam09742   1 MGASSSKLS--FRNAYLQLLSGTQPISADDPFWNQLLSFSLSIPLSSADVFLLEEALEPACEILALRNARTGNLATLLRK 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158187546   81 FLARTRELR--LSAEC-QNHIFIWQTHNALFIICCLLKVFICEMSEEELQLHFTYEEKLPG----TYSSDSEDLLEELLC 153
Cdd:pfam09742  79 FVERLVELKdsSRSASeQNDLFIWQALNALFLLRRILKYIIERASEEELLQHFEYENDDEGdedeEGSNRDLPLAESLLL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158187546  154 SLIQLITDTPLLDITYEISVEAISAMIVFLSCQLFHKEVLRQSISHKYLMQGPCL---PYTSKLVKTLLYNFIRQEKPPP 230
Cdd:pfam09742 159 ALVDLLFTVPLTDSTYALHTELLNLLLVLLSEQLYSPPSPADTSIFNPFMDGKCSadsSIALPLVTSLLNNFIAYDPVPS 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158187546  231 PGTHVFPQQSDGGGLLYGLASGVATGLWTVFTLGGvGSKAASPELTSPLANQSLLLLLVLVNLTDAPDIP-------NPY 303
Cdd:pfam09742 239 NSLDSDGGSGVPYNHLLGLVSDLASSLWLLPTLGG-SSESESEGTPEPLADQSLQLLLVLLDHGPTEDPVkspsggdNPY 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158187546  304 RQAVTSFKNTQDsspfpssvphtFQINFNSLYTTLCEQQTSDQA-TLLLYTLLHQNANVRTYMLARTDMENLVLPILEIL 382
Cdd:pfam09742 318 RNALSRLHDVED-----------FQIVFSGLFRTLCNTVPSEQTlLLLLYKLLHSNSKFLNYVLSRSDVLDLLVPILELL 386
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158187546  383 YHVEERNSHHVYMALIILLILTEDDGFNRSIHEVILKNITWYSERVLTEISLGSLLILVVIRTIQYNMTRTRDKYLHTNC 462
Cdd:pfam09742 387 YNARADNSHHIYMALIILLILSEDRNFNKRLHKPILKNVTWYSERVPTEISLGSLLILVLIRTIQYNHTRLRDKYLHTNC 466
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158187546  463 LAALANMSAQFRSLHQYAAQRIISLFSLLSKKHNKVLEQATQQADSVTFvrlsdlQSPVAQDLSVIEEVIRMMLEIINSC 542
Cdd:pfam09742 467 LAILANMSPYFKNLSPYASQRLVSLFELLSKKHFKLLSLANGKASNDLG------SDDLAQDLSVNEEVLRLLLEILNSI 540
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158187546  543 LTNSLHHNPNLVYALLYKRDLFEQFRTHPSFQDIMQNIDLVISFFSSRLLQSGAE---LSVERVLEIIKQGVVALPKDrl 619
Cdd:pfam09742 541 LQYQLDGNPNLVYALLRKREVFHQFANHPSFQDPLQNIDRVLQFFSPRVEKACADsglLSVSEILDIIQKGTLVGLLP-- 618
                         650       660
                  ....*....|....*....|....*..
gi 158187546  620 KKFPELKFKYVEEEQPEEFFIPYVWSL 646
Cdd:pfam09742 619 KPFPILKFKYVEEESPEEFFIPYVWSL 645
 
Name Accession Description Interval E-value
Dymeclin pfam09742
Dyggve-Melchior-Clausen syndrome protein; Dymeclin (Dyggve-Melchior-Clausen syndrome protein) ...
1-646 0e+00

Dyggve-Melchior-Clausen syndrome protein; Dymeclin (Dyggve-Melchior-Clausen syndrome protein) contains a large number of leucine and isoleucine residues and a total of 17 repeated dileucine motifs. It is characteriztically about 700 residues long and present in plants and animals. Mutations in the gene coding for this protein in humans give rise to the disorder Dyggve-Melchior-Clausen syndrome (DMC, MIM 223800) which is an autosomal-recessive disorder characterized by the association of a spondylo-epi-metaphyseal dysplasia and mental retardation. DYM transcripts are widely expressed throughout human development and Dymeclin is not an integral membrane protein of the ER, but rather a peripheral membrane protein dynamically associated with the Golgi apparatus.


Pssm-ID: 462873  Cd Length: 645  Bit Score: 733.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158187546    1 MGSNSSKISdlPKNEYLKRLSGPEAISENDPFWNQLFSFSFSAPTSSTELKLLEEATISVCKSLVENNPRTGNLAALTKV 80
Cdd:pfam09742   1 MGASSSKLS--FRNAYLQLLSGTQPISADDPFWNQLLSFSLSIPLSSADVFLLEEALEPACEILALRNARTGNLATLLRK 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158187546   81 FLARTRELR--LSAEC-QNHIFIWQTHNALFIICCLLKVFICEMSEEELQLHFTYEEKLPG----TYSSDSEDLLEELLC 153
Cdd:pfam09742  79 FVERLVELKdsSRSASeQNDLFIWQALNALFLLRRILKYIIERASEEELLQHFEYENDDEGdedeEGSNRDLPLAESLLL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158187546  154 SLIQLITDTPLLDITYEISVEAISAMIVFLSCQLFHKEVLRQSISHKYLMQGPCL---PYTSKLVKTLLYNFIRQEKPPP 230
Cdd:pfam09742 159 ALVDLLFTVPLTDSTYALHTELLNLLLVLLSEQLYSPPSPADTSIFNPFMDGKCSadsSIALPLVTSLLNNFIAYDPVPS 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158187546  231 PGTHVFPQQSDGGGLLYGLASGVATGLWTVFTLGGvGSKAASPELTSPLANQSLLLLLVLVNLTDAPDIP-------NPY 303
Cdd:pfam09742 239 NSLDSDGGSGVPYNHLLGLVSDLASSLWLLPTLGG-SSESESEGTPEPLADQSLQLLLVLLDHGPTEDPVkspsggdNPY 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158187546  304 RQAVTSFKNTQDsspfpssvphtFQINFNSLYTTLCEQQTSDQA-TLLLYTLLHQNANVRTYMLARTDMENLVLPILEIL 382
Cdd:pfam09742 318 RNALSRLHDVED-----------FQIVFSGLFRTLCNTVPSEQTlLLLLYKLLHSNSKFLNYVLSRSDVLDLLVPILELL 386
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158187546  383 YHVEERNSHHVYMALIILLILTEDDGFNRSIHEVILKNITWYSERVLTEISLGSLLILVVIRTIQYNMTRTRDKYLHTNC 462
Cdd:pfam09742 387 YNARADNSHHIYMALIILLILSEDRNFNKRLHKPILKNVTWYSERVPTEISLGSLLILVLIRTIQYNHTRLRDKYLHTNC 466
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158187546  463 LAALANMSAQFRSLHQYAAQRIISLFSLLSKKHNKVLEQATQQADSVTFvrlsdlQSPVAQDLSVIEEVIRMMLEIINSC 542
Cdd:pfam09742 467 LAILANMSPYFKNLSPYASQRLVSLFELLSKKHFKLLSLANGKASNDLG------SDDLAQDLSVNEEVLRLLLEILNSI 540
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158187546  543 LTNSLHHNPNLVYALLYKRDLFEQFRTHPSFQDIMQNIDLVISFFSSRLLQSGAE---LSVERVLEIIKQGVVALPKDrl 619
Cdd:pfam09742 541 LQYQLDGNPNLVYALLRKREVFHQFANHPSFQDPLQNIDRVLQFFSPRVEKACADsglLSVSEILDIIQKGTLVGLLP-- 618
                         650       660
                  ....*....|....*....|....*..
gi 158187546  620 KKFPELKFKYVEEEQPEEFFIPYVWSL 646
Cdd:pfam09742 619 KPFPILKFKYVEEESPEEFFIPYVWSL 645
 
Name Accession Description Interval E-value
Dymeclin pfam09742
Dyggve-Melchior-Clausen syndrome protein; Dymeclin (Dyggve-Melchior-Clausen syndrome protein) ...
1-646 0e+00

Dyggve-Melchior-Clausen syndrome protein; Dymeclin (Dyggve-Melchior-Clausen syndrome protein) contains a large number of leucine and isoleucine residues and a total of 17 repeated dileucine motifs. It is characteriztically about 700 residues long and present in plants and animals. Mutations in the gene coding for this protein in humans give rise to the disorder Dyggve-Melchior-Clausen syndrome (DMC, MIM 223800) which is an autosomal-recessive disorder characterized by the association of a spondylo-epi-metaphyseal dysplasia and mental retardation. DYM transcripts are widely expressed throughout human development and Dymeclin is not an integral membrane protein of the ER, but rather a peripheral membrane protein dynamically associated with the Golgi apparatus.


Pssm-ID: 462873  Cd Length: 645  Bit Score: 733.38  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158187546    1 MGSNSSKISdlPKNEYLKRLSGPEAISENDPFWNQLFSFSFSAPTSSTELKLLEEATISVCKSLVENNPRTGNLAALTKV 80
Cdd:pfam09742   1 MGASSSKLS--FRNAYLQLLSGTQPISADDPFWNQLLSFSLSIPLSSADVFLLEEALEPACEILALRNARTGNLATLLRK 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158187546   81 FLARTRELR--LSAEC-QNHIFIWQTHNALFIICCLLKVFICEMSEEELQLHFTYEEKLPG----TYSSDSEDLLEELLC 153
Cdd:pfam09742  79 FVERLVELKdsSRSASeQNDLFIWQALNALFLLRRILKYIIERASEEELLQHFEYENDDEGdedeEGSNRDLPLAESLLL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158187546  154 SLIQLITDTPLLDITYEISVEAISAMIVFLSCQLFHKEVLRQSISHKYLMQGPCL---PYTSKLVKTLLYNFIRQEKPPP 230
Cdd:pfam09742 159 ALVDLLFTVPLTDSTYALHTELLNLLLVLLSEQLYSPPSPADTSIFNPFMDGKCSadsSIALPLVTSLLNNFIAYDPVPS 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158187546  231 PGTHVFPQQSDGGGLLYGLASGVATGLWTVFTLGGvGSKAASPELTSPLANQSLLLLLVLVNLTDAPDIP-------NPY 303
Cdd:pfam09742 239 NSLDSDGGSGVPYNHLLGLVSDLASSLWLLPTLGG-SSESESEGTPEPLADQSLQLLLVLLDHGPTEDPVkspsggdNPY 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158187546  304 RQAVTSFKNTQDsspfpssvphtFQINFNSLYTTLCEQQTSDQA-TLLLYTLLHQNANVRTYMLARTDMENLVLPILEIL 382
Cdd:pfam09742 318 RNALSRLHDVED-----------FQIVFSGLFRTLCNTVPSEQTlLLLLYKLLHSNSKFLNYVLSRSDVLDLLVPILELL 386
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158187546  383 YHVEERNSHHVYMALIILLILTEDDGFNRSIHEVILKNITWYSERVLTEISLGSLLILVVIRTIQYNMTRTRDKYLHTNC 462
Cdd:pfam09742 387 YNARADNSHHIYMALIILLILSEDRNFNKRLHKPILKNVTWYSERVPTEISLGSLLILVLIRTIQYNHTRLRDKYLHTNC 466
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158187546  463 LAALANMSAQFRSLHQYAAQRIISLFSLLSKKHNKVLEQATQQADSVTFvrlsdlQSPVAQDLSVIEEVIRMMLEIINSC 542
Cdd:pfam09742 467 LAILANMSPYFKNLSPYASQRLVSLFELLSKKHFKLLSLANGKASNDLG------SDDLAQDLSVNEEVLRLLLEILNSI 540
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158187546  543 LTNSLHHNPNLVYALLYKRDLFEQFRTHPSFQDIMQNIDLVISFFSSRLLQSGAE---LSVERVLEIIKQGVVALPKDrl 619
Cdd:pfam09742 541 LQYQLDGNPNLVYALLRKREVFHQFANHPSFQDPLQNIDRVLQFFSPRVEKACADsglLSVSEILDIIQKGTLVGLLP-- 618
                         650       660
                  ....*....|....*....|....*..
gi 158187546  620 KKFPELKFKYVEEEQPEEFFIPYVWSL 646
Cdd:pfam09742 619 KPFPILKFKYVEEESPEEFFIPYVWSL 645
Hid1 pfam12722
High-temperature-induced dauer-formation protein; Hid1 (high-temperature-induced ...
347-571 1.18e-06

High-temperature-induced dauer-formation protein; Hid1 (high-temperature-induced dauer-formation protein 1) represents proteins of approximately 800 residues long and is conserved from fungi to humans. Functionally it might be involved in vesicle secretion or be an inter-cellular signalling protein or be a novel insulin receptor. It was previously thought to contain up to seven potential transmembrane domains separated by regions of low complexity. However, biochemical membrane fraction analysis demonstrate that HID-1 is a peripheral membrane protein tightly associated with the Golgi apparatus but not a transmembrane protein predicted by the bioinformatic programs. Furthermore, it contains a conserved N-terminal myristoylation site was required for HID-1 binding to the Golgi apparatus.


Pssm-ID: 463680 [Multi-domain]  Cd Length: 804  Bit Score: 52.03  E-value: 1.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158187546  347 ATLLLYTLLHQNANVRTYMLARTDMENLVLPileILYHV-EERN--SH--HVYMALIILLILTEDDGFNRSIHEVILKNi 421
Cdd:pfam12722 371 MLMLFWELLQCNKRFRSYVIDTSRALDLLVP---ILYYAfEYRSdpSKkgLVKICVFILLLLSGEKNFGVRLNKPFEAQ- 446
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158187546  422 twysERVLTEI-------SLGSLLILVVIRTIQYNMTRTRDkyLHTNCLAALANMSAQFRSLHQYAAQRIISLFSLLSkk 494
Cdd:pfam12722 447 ----ETLPTSIripfftgTYADFLITVIHKLITTGKGRLSE--LVPCLLEILVNLSPYLKGLSMVACSKLLQLFESFS-- 518
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 158187546  495 hnkvleqatqqadSVTFVrlsdLQSPVAQDLsvieevIRMMLEIINSCLTNSLHHNPNLVYALLYKRDLFEQFRTHP 571
Cdd:pfam12722 519 -------------SPSFL----LANPSNHKL------LASLLEAFNNAIQYQFDGNPNLVYSILRNRKVFEALRNLT 572
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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