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Conserved domains on  [gi|1983576068|ref|NP_001099602|]
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lipoxygenase homology domain-containing protein 1 isoform 1 [Rattus norvegicus]

Protein Classification

phospholipase C( domain architecture ID 10109883)

phospholipase C catayzes the hydroysis of a phosphatidylcholine to form 1,2-diacyl-sn-glycerol and phosphocholine

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1026-1146 5.56e-61

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 204.71  E-value: 5.56e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1026 NTYEVQVITGNVPKAGTDANVYLTIYGEeYGDTGERPLKKSDKSNKFEQGQTDTFTIYAIDLGALTKIRIRHDNTGNRPG 1105
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGE-NGDTGKRKLKKSNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1983576068 1106 WFLDRIDITDVNNETTYYFPCQRWLAVEEDDGQLSRELLPV 1146
Cdd:cd01756     80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1180-1300 4.27e-57

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 193.54  E-value: 4.27e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1180 TTFSVTIKTGDKKNAGTDANVFITLFGTKDNNGMTLLKSSkTNSDKFERDSIEIFTVETLDLGDLWKVRIGHDNTGKAPG 1259
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKS-NNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1983576068 1260 WFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIVRDLFHA 1300
Cdd:cd01756     80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 172-289 1.63e-55

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 188.92  E-value: 1.63e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  172 NKYEIKVYTGDVIGAGTDADVFINIFGEYGDTGERRLE--NEKDNFEKGAEDKFTLDAPDLGQLMKINVGHNNKGGSAGW 249
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKksNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1983576068  250 FLSKIIIEDIGNKRKYDFPLNRWLALDEDDGKIQRDILVG 289
Cdd:cd01756     81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 2097-2215 2.78e-55

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 188.15  E-value: 2.78e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 2097 VKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQK-MRNLFERGSTDRFFLETLELGELRKVRLEHDSSGYYSGW 2175
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSnNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1983576068 2176 LVEKVEVTNTSTGVATIFSCGRWLDKSRGDGLTWRELFPS 2215
Cdd:cd01756     81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1465-1585 8.69e-54

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 183.91  E-value: 8.69e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1465 VLYSVQIFTGNVPGAGTDAKVYITIYGDLGDTGERYLGKSENRtNKFEKGTADTFIIEAADLGVIYKIKLRHDNTKWCAD 1544
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNK-NKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1983576068 1545 WYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEK 1585
Cdd:cd01756     80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 684-805 3.48e-53

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 182.37  E-value: 3.48e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  684 FRYHISVKTGDVSGASTDSRVYIKLYGEKSDTIKQVLLVSDNnlKDYFERGRVDEFTLETLNIGTIIRLVIGHDSTGMHA 763
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNN--KNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGA 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1983576068  764 GWFLGSVQIRVPRQGKQYTFPANRWLDKNQADGRLEVELYPS 805
Cdd:cd01756     79 GWFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1828-1948 9.76e-52

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 178.13  E-value: 9.76e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1828 TSYTVSVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFpDMLSLGHLCKLRVWHDNKGIFPG 1907
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNKNKFERGQTDKFTV-EAVDLGKLKKIRIGHDNSGLGAG 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1983576068 1908 WHLSYIDVKDNSRDETFRFQCDCWLSKSEGDRQTLRDFACA 1948
Cdd:cd01756     80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 43-162 5.95e-50

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 173.12  E-value: 5.95e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068   43 KVYEVVTATGDVRGAGTDANVFITIFGENGLSPKLHL-TSKSESAFEKANVDVFRVRTNNVGLIYKIRIEHDNTGLNASW 121
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLkKSNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1983576068  122 YLDRVIVTDMKRpHLRYYFNCNNWLSKVEGDRQWCRDLLAS 162
Cdd:cd01756     81 FLDKVEIREPGT-GDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 554-675 2.01e-48

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 168.89  E-value: 2.01e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  554 RYRVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCrNNTDLFEKGNADEFTIESVTMRKVRRVRVRHDGKGSGSGW 633
Cdd:cd01756      2 TYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKS-NNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1983576068  634 YLDRVLVREEGQpeSDNVEFPCLRWLDKDKDDGQLVRELLPS 675
Cdd:cd01756     81 FLDKVEIREPGT--GDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 425-542 5.73e-46

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 161.57  E-value: 5.73e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  425 FPWSLWVWTTDLKKAGTNSPIFIQIYGKKGRTDEILLNPNNK--WFKPGIIEKFRMELPDLGRFYKIRAWHDRQNPGSGW 502
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNknKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1983576068  503 HLEKMTLMNTLNKDKYNFNCNRWLDANEDDNEIVREMTAE 542
Cdd:cd01756     81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1311-1437 3.91e-45

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 159.26  E-value: 3.91e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1311 VPYEITLYTSDVFAAGTDANVFIVIYGcDAVCTRQKFLCTNKREQKllFERKSASRFIVELEDVGEiIEKIRIGHDNTGI 1390
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYG-ENGDTGKRKLKKSNNKNK--FERGQTDKFTVEAVDLGK-LKKIRIGHDNSGL 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1983576068 1391 NPGWHCSHVDIRRLLPekdgTETLTFPCDRWLATSEDDKKTIRELVP 1437
Cdd:cd01756     77 GAGWFLDKVEIREPGT----GDEYTFPCNRWLDKDEDDGQIVRELYP 119
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 296-414 2.20e-44

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 157.33  E-value: 2.20e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  296 ITYIVTVFTGDIRGAGTKSKIYLVMYGARGNrnSGKIFLE----GGVFDRGRTDIFHIDlAVLLSPLSRVSIGHGNIGVN 371
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGD--TGKRKLKksnnKNKFERGQTDKFTVE-AVDLGKLKKIRIGHDNSGLG 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1983576068  372 RGWYCEKVVVLCPFTGIQQTFPCSNWLDEKKADGLIERQLYEM 414
Cdd:cd01756     78 AGWFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1701-1818 2.56e-44

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 156.95  E-value: 2.56e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1701 VLYEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEVQLDKK--KARFEREQNDTFIMEILDIAPFTKMRIRIDGLGSRPEW 1778
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSnnKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1983576068 1779 FLERILLKNMNTGDLTMFYYGDWLSQKKGKKTLVCEICAV 1818
Cdd:cd01756     81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT super family cl00011
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 816-896 1.44e-27

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


The actual alignment was detected with superfamily member cd01756:

Pssm-ID: 412108  Cd Length: 120  Bit Score: 109.18  E-value: 1.44e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  816 YEIEIWTGDVGGAGTTSRVYVQIYGEEGKTEVLFL--SSRSKVFDRGSKDIFQLEAADVGEIYKIRLGHTGEGFGPSWFV 893
Cdd:cd01756      3 YEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLkkSNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGWFL 82


                   ...
gi 1983576068  894 DTV 896
Cdd:cd01756     83 DKV 85
PLAT super family cl00011
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 1961-2062 8.12e-05

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


The actual alignment was detected with superfamily member cd00113:

Pssm-ID: 412108  Cd Length: 116  Bit Score: 43.87  E-value: 8.12e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1961 YEIVIETGN--GGETRENIWLILEGR-KNRSKEFLVENSSRqraFRKGTTDTFEFDsiFLGDIASLCVGHLAREDrfiPK 2037
Cdd:cd00113      3 YTVTIKTGDkkGAGTDSNISLALYGEnGNSSDIPILDGPGS---FERGSTDTFQID--LKLDIGDITKVYLRRDG---SG 74

                           90       100
                   ....*....|....*....|....*
gi 1983576068 2038 RELVWHVKTITITEMEYGNVYFFNC 2062
Cdd:cd00113     75 LSDGWYCESITVQALGTKKVYTFPV 99
PLAT super family cl00011
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 1634-1699 6.44e-03

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


The actual alignment was detected with superfamily member cd02899:

Pssm-ID: 412108  Cd Length: 109  Bit Score: 38.60  E-value: 6.44e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1983576068 1634 YYVSVTTGKHKEAATDSRAFVLLIGEdDERTNRIWLdfpqgKRGFSCGSVEEFYVGGLDVGIIKKI 1699
Cdd:cd02899      3 YTASVQTGKDKEAGTNGTIEITLLGS-SGRSNPKTL-----SQGFYPGSLKRIRFRAADVGDINAI 62
 
Name Accession Description Interval E-value
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1026-1146 5.56e-61

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 204.71  E-value: 5.56e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1026 NTYEVQVITGNVPKAGTDANVYLTIYGEeYGDTGERPLKKSDKSNKFEQGQTDTFTIYAIDLGALTKIRIRHDNTGNRPG 1105
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGE-NGDTGKRKLKKSNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1983576068 1106 WFLDRIDITDVNNETTYYFPCQRWLAVEEDDGQLSRELLPV 1146
Cdd:cd01756     80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1180-1300 4.27e-57

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 193.54  E-value: 4.27e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1180 TTFSVTIKTGDKKNAGTDANVFITLFGTKDNNGMTLLKSSkTNSDKFERDSIEIFTVETLDLGDLWKVRIGHDNTGKAPG 1259
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKS-NNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1983576068 1260 WFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIVRDLFHA 1300
Cdd:cd01756     80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 172-289 1.63e-55

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 188.92  E-value: 1.63e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  172 NKYEIKVYTGDVIGAGTDADVFINIFGEYGDTGERRLE--NEKDNFEKGAEDKFTLDAPDLGQLMKINVGHNNKGGSAGW 249
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKksNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1983576068  250 FLSKIIIEDIGNKRKYDFPLNRWLALDEDDGKIQRDILVG 289
Cdd:cd01756     81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 2097-2215 2.78e-55

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 188.15  E-value: 2.78e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 2097 VKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQK-MRNLFERGSTDRFFLETLELGELRKVRLEHDSSGYYSGW 2175
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSnNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1983576068 2176 LVEKVEVTNTSTGVATIFSCGRWLDKSRGDGLTWRELFPS 2215
Cdd:cd01756     81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1465-1585 8.69e-54

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 183.91  E-value: 8.69e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1465 VLYSVQIFTGNVPGAGTDAKVYITIYGDLGDTGERYLGKSENRtNKFEKGTADTFIIEAADLGVIYKIKLRHDNTKWCAD 1544
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNK-NKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1983576068 1545 WYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEK 1585
Cdd:cd01756     80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 684-805 3.48e-53

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 182.37  E-value: 3.48e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  684 FRYHISVKTGDVSGASTDSRVYIKLYGEKSDTIKQVLLVSDNnlKDYFERGRVDEFTLETLNIGTIIRLVIGHDSTGMHA 763
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNN--KNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGA 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1983576068  764 GWFLGSVQIRVPRQGKQYTFPANRWLDKNQADGRLEVELYPS 805
Cdd:cd01756     79 GWFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1828-1948 9.76e-52

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 178.13  E-value: 9.76e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1828 TSYTVSVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFpDMLSLGHLCKLRVWHDNKGIFPG 1907
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNKNKFERGQTDKFTV-EAVDLGKLKKIRIGHDNSGLGAG 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1983576068 1908 WHLSYIDVKDNSRDETFRFQCDCWLSKSEGDRQTLRDFACA 1948
Cdd:cd01756     80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 43-162 5.95e-50

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 173.12  E-value: 5.95e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068   43 KVYEVVTATGDVRGAGTDANVFITIFGENGLSPKLHL-TSKSESAFEKANVDVFRVRTNNVGLIYKIRIEHDNTGLNASW 121
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLkKSNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1983576068  122 YLDRVIVTDMKRpHLRYYFNCNNWLSKVEGDRQWCRDLLAS 162
Cdd:cd01756     81 FLDKVEIREPGT-GDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 554-675 2.01e-48

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 168.89  E-value: 2.01e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  554 RYRVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCrNNTDLFEKGNADEFTIESVTMRKVRRVRVRHDGKGSGSGW 633
Cdd:cd01756      2 TYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKS-NNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1983576068  634 YLDRVLVREEGQpeSDNVEFPCLRWLDKDKDDGQLVRELLPS 675
Cdd:cd01756     81 FLDKVEIREPGT--GDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 425-542 5.73e-46

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 161.57  E-value: 5.73e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  425 FPWSLWVWTTDLKKAGTNSPIFIQIYGKKGRTDEILLNPNNK--WFKPGIIEKFRMELPDLGRFYKIRAWHDRQNPGSGW 502
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNknKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1983576068  503 HLEKMTLMNTLNKDKYNFNCNRWLDANEDDNEIVREMTAE 542
Cdd:cd01756     81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1311-1437 3.91e-45

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 159.26  E-value: 3.91e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1311 VPYEITLYTSDVFAAGTDANVFIVIYGcDAVCTRQKFLCTNKREQKllFERKSASRFIVELEDVGEiIEKIRIGHDNTGI 1390
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYG-ENGDTGKRKLKKSNNKNK--FERGQTDKFTVEAVDLGK-LKKIRIGHDNSGL 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1983576068 1391 NPGWHCSHVDIRRLLPekdgTETLTFPCDRWLATSEDDKKTIRELVP 1437
Cdd:cd01756     77 GAGWFLDKVEIREPGT----GDEYTFPCNRWLDKDEDDGQIVRELYP 119
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 296-414 2.20e-44

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 157.33  E-value: 2.20e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  296 ITYIVTVFTGDIRGAGTKSKIYLVMYGARGNrnSGKIFLE----GGVFDRGRTDIFHIDlAVLLSPLSRVSIGHGNIGVN 371
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGD--TGKRKLKksnnKNKFERGQTDKFTVE-AVDLGKLKKIRIGHDNSGLG 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1983576068  372 RGWYCEKVVVLCPFTGIQQTFPCSNWLDEKKADGLIERQLYEM 414
Cdd:cd01756     78 AGWFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1701-1818 2.56e-44

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 156.95  E-value: 2.56e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1701 VLYEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEVQLDKK--KARFEREQNDTFIMEILDIAPFTKMRIRIDGLGSRPEW 1778
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSnnKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1983576068 1779 FLERILLKNMNTGDLTMFYYGDWLSQKKGKKTLVCEICAV 1818
Cdd:cd01756     81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 816-896 1.44e-27

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 109.18  E-value: 1.44e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  816 YEIEIWTGDVGGAGTTSRVYVQIYGEEGKTEVLFL--SSRSKVFDRGSKDIFQLEAADVGEIYKIRLGHTGEGFGPSWFV 893
Cdd:cd01756      3 YEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLkkSNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGWFL 82


                   ...
gi 1983576068  894 DTV 896
Cdd:cd01756     83 DKV 85
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1028-1135 3.49e-24

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 99.43  E-value: 3.49e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1028 YEVQVITGNVPKAGTDANVYLTIYGEEyGDTGERPLKKSDKSnkFEQGQTDTFTIYA-IDLGALTKIRIRHDNTGNRPGW 1106
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKV-GESAQLEITLDNPD--FERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDEW 77

                           90       100       110
                   ....*....|....*....|....*....|
gi 1983576068 1107 FLDRIDIT-DVNNETTYYFPCQRWLAVEED 1135
Cdd:pfam01477   78 FLKSITVEvPGETGGKYTFPCNSWVYGSKK 107
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 174-273 2.40e-20

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 88.26  E-value: 2.40e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  174 YEIKVYTGDVIGAGTDADVFINIFGEYGDTGERRLENEKDNFEKGAEDKFTLDAP-DLGQLMKINVGHNNKGGSAGWFLS 252
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGAEDSFEIDTDwDVGAILKINLHWDNNGLSDEWFLK 80

                           90       100
                   ....*....|....*....|..
gi 1983576068  253 KIIIEDIG-NKRKYDFPLNRWL 273
Cdd:pfam01477   81 SITVEVPGeTGGKYTFPCNSWV 102
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1830-1942 3.06e-20

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 87.87  E-value: 3.06e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1830 YTVSVKTSDILGAGTDANVFIIIFGENGDSGTLALKQsaNWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPGWH 1909
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITL--DNPDFERGAEDSFEIDTDWDVGAILKINLHWDNNGLSDEWF 78

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1983576068 1910 LSYIDVKDNSRDE-TFRFQCDCWLSKSEGDRQTL 1942
Cdd:pfam01477   79 LKSITVEVPGETGgKYTFPCNSWVYGSKKYKETR 112
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1182-1289 1.05e-19

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 86.72  E-value: 1.05e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1182 FSVTIKTGDKKNAGTDANVFITLFGTKDNngMTLLKSSKTNSDkFERDSIEIFTVET-LDLGDLWKVRIGHDNTGKAPGW 1260
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGE--SAQLEITLDNPD-FERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDEW 77

                           90       100       110
                   ....*....|....*....|....*....|
gi 1983576068 1261 FVDWVEVDAPSL-GKCMTFPCGRWLAKNED 1289
Cdd:pfam01477   78 FLKSITVEVPGEtGGKYTFPCNSWVYGSKK 107
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 298-402 1.26e-19

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 86.33  E-value: 1.26e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  298 YIVTVFTGDIRGAGTKSKIYLVMYGARGNRNSGKIFLEGGVFDRGRTDIFHIDLAVLLSPLSRVSIGHGNIGVNRGWYCE 377
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGAEDSFEIDTDWDVGAILKINLHWDNNGLSDEWFLK 80

                           90       100
                   ....*....|....*....|....*.
gi 1983576068  378 KVVVLCP-FTGIQQTFPCSNWLDEKK 402
Cdd:pfam01477   81 SITVEVPgETGGKYTFPCNSWVYGSK 106
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 45-148 2.54e-19

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 85.56  E-value: 2.54e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068   45 YEVVTATGDVRGAGTDANVFITIFGENGLSPKLHLTSKSESaFEKANVDVFRVRT-NNVGLIYKIRIEHDNTGLNASWYL 123
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPD-FERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDEWFL 79

                           90       100
                   ....*....|....*....|....*
gi 1983576068  124 DRVIVTDMKRPHLRYYFNCNNWLSK 148
Cdd:pfam01477   80 KSITVEVPGETGGKYTFPCNSWVYG 104
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 2099-2208 3.94e-18

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 82.09  E-value: 3.94e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 2099 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKmRNLFERGSTDRFFLET-LELGELRKVRLEHDSSGYYSGWLV 2177
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLD-NPDFERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDEWFL 79

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1983576068 2178 EKVEVT-NTSTGVATIFSCGRWLDKSRGDGLT 2208
Cdd:pfam01477   80 KSITVEvPGETGGKYTFPCNSWVYGSKKYKET 111
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 686-793 5.98e-18

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 81.71  E-value: 5.98e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  686 YHISVKTGDVSGASTDSRVYIKLYGEKSDTIKQVLLVSDNNlkdyFERGRVDEFTLET-LNIGTIIRLVIGHDSTGMHAG 764
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPD----FERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDE 76

                           90       100       110
                   ....*....|....*....|....*....|
gi 1983576068  765 WFLGSVQIRVPRQ-GKQYTFPANRWLDKNQ 793
Cdd:pfam01477   77 WFLKSITVEVPGEtGGKYTFPCNSWVYGSK 106
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1467-1582 1.00e-17

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 80.94  E-value: 1.00e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1467 YSVQIFTGNVPGAGTDAKVYITIYGDLGDTGERYLGKSENRtnkFEKGTADTFII-EAADLGVIYKIKLRHDNTKWCADW 1545
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPD---FERGAEDSFEIdTDWDVGAILKINLHWDNNGLSDEW 77

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1983576068 1546 YVEKVEIW-NDTNEDEFLFLCGRWLSlKKEDGRLERLF 1582
Cdd:pfam01477   78 FLKSITVEvPGETGGKYTFPCNSWVY-GSKKYKETRVF 114
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 427-534 1.26e-15

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 74.78  E-value: 1.26e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  427 WSLWVWTTDLKKAGTNSPIFIQIYGKKGRTDEILLNPNNKWFKPGIIEKFRMELP-DLGRFYKIRAWHDRQNPGSGWHLE 505
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGAEDSFEIDTDwDVGAILKINLHWDNNGLSDEWFLK 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 1983576068  506 KMTLM-NTLNKDKYNFNCNRWLDANEDDNE 534
Cdd:pfam01477   81 SITVEvPGETGGKYTFPCNSWVYGSKKYKE 110
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
173-273 1.80e-14

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 71.13  E-value: 1.80e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068   173 KYEIKVYTGDVIGAGTDADVFINIFGEYGDTGERRL-ENEKDNFEKGAEDKFTLDAP-DLGQLMKINVgHNNKGGSAgWF 250
Cdd:smart00308    2 KYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLdYLFKGIFARGSTYEFTFDVDeDFGELGAVKI-KNEHRHPE-WF 79

                            90       100
                    ....*....|....*....|...
gi 1983576068   251 LSKIIIEDIGNKRKYDFPLNRWL 273
Cdd:smart00308   80 LKSITVKDLPTGGKYHFPCNSWV 102
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 816-899 1.02e-13

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 69.38  E-value: 1.02e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  816 YEIEIWTGDVGGAGTTSRVYVQIYGEEGKTEVLFLSSRSKVFDRGSKDIFQL-EAADVGEIYKIRLGHTGEGFGPSWFVD 894
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGAEDSFEIdTDWDVGAILKINLHWDNNGLSDEWFLK 80


                   ....*
gi 1983576068  895 TVWLR 899
Cdd:pfam01477   81 SITVE 85
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1028-1130 1.05e-13

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 69.21  E-value: 1.05e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  1028 YEVQVITGNVPKAGTDANVYLTIYGEEyGDTGERPLKKSDKsNKFEQGQTDTFTI-YAIDLGALTKIRIRHDNtgNRPGW 1106
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAE-GDGKESKLDYLFK-GIFARGSTYEFTFdVDEDFGELGAVKIKNEH--RHPEW 78

                            90       100
                    ....*....|....*....|....
gi 1983576068  1107 FLDRIDITDVNNETTYYFPCQRWL 1130
Cdd:smart00308   79 FLKSITVKDLPTGGKYHFPCNSWV 102
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1313-1431 1.80e-13

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 68.61  E-value: 1.80e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1313 YEITLYTSDVFAAGTDANVFIVIYGCDAVCTRQKFLCTNKReqkllFERKSASRFIVELE-DVGEIIeKIRIGHDNTGIN 1391
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPD-----FERGAEDSFEIDTDwDVGAIL-KINLHWDNNGLS 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1983576068 1392 PGWHCSHVdirRLLPEKDGTETLTFPCDRWLATSEDDKKT 1431
Cdd:pfam01477   75 DEWFLKSI---TVEVPGETGGKYTFPCNSWVYGSKKYKET 111
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1703-1810 2.99e-13

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 68.23  E-value: 2.99e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1703 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEVQLDKKKARFEREQNDTFIMEI-LDIAPFTKMRIRIDGLGSRPEWFLE 1781
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDEWFLK 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 1983576068 1782 RILL-KNMNTGDLTMFYYGDWLSQKKGKKT 1810
Cdd:pfam01477   81 SITVeVPGETGGKYTFPCNSWVYGSKKYKE 110
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1184-1287 3.30e-13

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 67.67  E-value: 3.30e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  1184 VTIKTGDKKNAGTDANVFITLFGTKDNNGMTLLKSSKTNSdkFERDSIEIFTVET-LDLGDLWKVRIGHDNtgKAPGWFV 1262
Cdd:smart00308    5 VTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGI--FARGSTYEFTFDVdEDFGELGAVKIKNEH--RHPEWFL 80

                            90       100
                    ....*....|....*....|....*
gi 1983576068  1263 DWVEVDAPSLGKCMTFPCGRWLAKN 1287
Cdd:smart00308   81 KSITVKDLPTGGKYHFPCNSWVYPD 105
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 555-664 6.01e-13

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 67.07  E-value: 6.01e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  555 YRVTVCTGELEGAGTDANVYLCLFGDVGDTGerLLYNCRNNTDlFEKGNADEFTI-ESVTMRKVRRVRVRHDGKGSGSGW 633
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESA--QLEITLDNPD-FERGAEDSFEIdTDWDVGAILKINLHWDNNGLSDEW 77

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1983576068  634 YLDRVLVREEGQPESdNVEFPCLRWLDKDKD 664
Cdd:pfam01477   78 FLKSITVEVPGETGG-KYTFPCNSWVYGSKK 107
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
2098-2201 1.38e-12

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 65.74  E-value: 1.38e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  2098 KYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLET-LELGELRKVRLEHDssGYYSGWL 2176
Cdd:smart00308    2 KYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGIFARGSTYEFTFDVdEDFGELGAVKIKNE--HRHPEWF 79

                            90       100
                    ....*....|....*....|....*
gi 1983576068  2177 VEKVEVTNTSTGVATIFSCGRWLDK 2201
Cdd:smart00308   80 LKSITVKDLPTGGKYHFPCNSWVYP 104
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
431-527 1.08e-10

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 60.35  E-value: 1.08e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068   431 VWTTDLKKAGTNSPIFIQIYGKKGRTDEILLNPNNKW-FKPGIIEKFRMELP-DLGRFYKIRAWHdrQNPGSGWHLEKMT 508
Cdd:smart00308    7 VTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGiFARGSTYEFTFDVDeDFGELGAVKIKN--EHRHPEWFLKSIT 84

                            90
                    ....*....|....*....
gi 1983576068   509 LMNTLNKDKYNFNCNRWLD 527
Cdd:smart00308   85 VKDLPTGGKYHFPCNSWVY 103
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
684-792 5.57e-10

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 58.42  E-value: 5.57e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068   684 FRYHISVKTGDVSGASTDSRVYIKLYGEKSDTIKQVLlvsDNNLKDYFERGRVDEFTLET-LNIGTI--IRLVIGHDstg 760
Cdd:smart00308    1 GKYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKL---DYLFKGIFARGSTYEFTFDVdEDFGELgaVKIKNEHR--- 74

                            90       100       110
                    ....*....|....*....|....*....|..
gi 1983576068   761 mHAGWFLGSVQIRVPRQGKQYTFPANRWLDKN 792
Cdd:smart00308   75 -HPEWFLKSITVKDLPTGGKYHFPCNSWVYPD 105
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1830-1934 2.60e-08

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 53.80  E-value: 2.60e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  1830 YTVSVKTSDILGAGTDANVFIIIFGENGDSGtLALKQSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKgiFPGWH 1909
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGK-ESKLDYLFKGIFARGSTYEFTFDVDEDFGELGAVKIKNEHR--HPEWF 79

                            90       100
                    ....*....|....*....|....*
gi 1983576068  1910 LSYIDVKDNSRDETFRFQCDCWLSK 1934
Cdd:smart00308   80 LKSITVKDLPTGGKYHFPCNSWVYP 104
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
298-401 4.57e-08

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 53.03  E-value: 4.57e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068   298 YIVTVFTGDIRGAGTKSKIYLVMYGARG-NRNSGKIFLEGGVFDRGRTDIFHIDLAVLLSPLSRVSIGHGNIGvnRGWYC 376
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGdGKESKLDYLFKGIFARGSTYEFTFDVDEDFGELGAVKIKNEHRH--PEWFL 80

                            90       100
                    ....*....|....*....|....*
gi 1983576068   377 EKVVVLCPFTGIQQTFPCSNWLDEK 401
Cdd:smart00308   81 KSITVKDLPTGGKYHFPCNSWVYPD 105
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
553-662 9.58e-08

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 51.87  E-value: 9.58e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068   553 ARYRVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNtdLFEKGNADEFTIESVTMRKVRRVRVRHDGKGSgSG 632
Cdd:smart00308    1 GKYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKG--IFARGSTYEFTFDVDEDFGELGAVKIKNEHRH-PE 77

                            90       100       110
                    ....*....|....*....|....*....|
gi 1983576068   633 WYLDRVLVreEGQPESDNVEFPCLRWLDKD 662
Cdd:smart00308   78 WFLKSITV--KDLPTGGKYHFPCNSWVYPD 105
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1467-1572 1.07e-07

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 51.87  E-value: 1.07e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  1467 YSVQIFTGNVPGAGTDAKVYITIYGDLGDTGERYLGKSENrtNKFEKGTADTFIIE-AADLGVIYKIKLRHDNTKwcADW 1545
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFK--GIFARGSTYEFTFDvDEDFGELGAVKIKNEHRH--PEW 78

                            90       100
                    ....*....|....*....|....*..
gi 1983576068  1546 YVEKVEIWNDTNEDEFLFLCGRWLSLK 1572
Cdd:smart00308   79 FLKSITVKDLPTGGKYHFPCNSWVYPD 105
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
45-148 3.36e-07

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 50.33  E-value: 3.36e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068    45 YEVVTATGDVRGAGTDANVFITIFGENGLSPKLHLTSKSESAFEKANVDVFRVRTN-NVGLIYKIRIEHDNTGlnASWYL 123
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGIFARGSTYEFTFDVDeDFGELGAVKIKNEHRH--PEWFL 80

                            90       100
                    ....*....|....*....|....*
gi 1983576068   124 DRVIVTDMKrPHLRYYFNCNNWLSK 148
Cdd:smart00308   81 KSITVKDLP-TGGKYHFPCNSWVYP 104
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1703-1803 1.16e-05

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 46.10  E-value: 1.16e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  1703 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEVQLDK-KKARFEREQNDTFIMEI-LDIAPFTKMRIRIDglGSRPEWFL 1780
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYlFKGIFARGSTYEFTFDVdEDFGELGAVKIKNE--HRHPEWFL 80

                            90       100
                    ....*....|....*....|...
gi 1983576068  1781 ERILLKNMNTGDLTMFYYGDWLS 1803
Cdd:smart00308   81 KSITVKDLPTGGKYHFPCNSWVY 103
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 1961-2062 8.12e-05

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 43.87  E-value: 8.12e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1961 YEIVIETGN--GGETRENIWLILEGR-KNRSKEFLVENSSRqraFRKGTTDTFEFDsiFLGDIASLCVGHLAREDrfiPK 2037
Cdd:cd00113      3 YTVTIKTGDkkGAGTDSNISLALYGEnGNSSDIPILDGPGS---FERGSTDTFQID--LKLDIGDITKVYLRRDG---SG 74

                           90       100
                   ....*....|....*....|....*
gi 1983576068 2038 RELVWHVKTITITEMEYGNVYFFNC 2062
Cdd:cd00113     75 LSDGWYCESITVQALGTKKVYTFPV 99
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
815-896 1.07e-04

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 43.40  E-value: 1.07e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068   815 HYEIEIWTGDVGGAGTTSRVYVQIYGEEGKTEVLFLSSRSKV-FDRGSKDIFQLE-AADVGEIYKIRLghTGEGFGPSWF 892
Cdd:smart00308    2 KYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGiFARGSTYEFTFDvDEDFGELGAVKI--KNEHRHPEWF 79


                    ....
gi 1983576068   893 VDTV 896
Cdd:smart00308   80 LKSI 83
PLAT_SR cd02899
Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) ...
 1634-1699 6.44e-03

Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates. This subfamily contains Toxoplasma gondii Scavenger protein TgSR1.


Pssm-ID: 239228  Cd Length: 109  Bit Score: 38.60  E-value: 6.44e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1983576068 1634 YYVSVTTGKHKEAATDSRAFVLLIGEdDERTNRIWLdfpqgKRGFSCGSVEEFYVGGLDVGIIKKI 1699
Cdd:cd02899      3 YTASVQTGKDKEAGTNGTIEITLLGS-SGRSNPKTL-----SQGFYPGSLKRIRFRAADVGDINAI 62
 
Name Accession Description Interval E-value
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1026-1146 5.56e-61

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 204.71  E-value: 5.56e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1026 NTYEVQVITGNVPKAGTDANVYLTIYGEeYGDTGERPLKKSDKSNKFEQGQTDTFTIYAIDLGALTKIRIRHDNTGNRPG 1105
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGE-NGDTGKRKLKKSNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1983576068 1106 WFLDRIDITDVNNETTYYFPCQRWLAVEEDDGQLSRELLPV 1146
Cdd:cd01756     80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1180-1300 4.27e-57

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 193.54  E-value: 4.27e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1180 TTFSVTIKTGDKKNAGTDANVFITLFGTKDNNGMTLLKSSkTNSDKFERDSIEIFTVETLDLGDLWKVRIGHDNTGKAPG 1259
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKS-NNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1983576068 1260 WFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIVRDLFHA 1300
Cdd:cd01756     80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 172-289 1.63e-55

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 188.92  E-value: 1.63e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  172 NKYEIKVYTGDVIGAGTDADVFINIFGEYGDTGERRLE--NEKDNFEKGAEDKFTLDAPDLGQLMKINVGHNNKGGSAGW 249
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKksNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1983576068  250 FLSKIIIEDIGNKRKYDFPLNRWLALDEDDGKIQRDILVG 289
Cdd:cd01756     81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 2097-2215 2.78e-55

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 188.15  E-value: 2.78e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 2097 VKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQK-MRNLFERGSTDRFFLETLELGELRKVRLEHDSSGYYSGW 2175
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSnNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1983576068 2176 LVEKVEVTNTSTGVATIFSCGRWLDKSRGDGLTWRELFPS 2215
Cdd:cd01756     81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1465-1585 8.69e-54

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 183.91  E-value: 8.69e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1465 VLYSVQIFTGNVPGAGTDAKVYITIYGDLGDTGERYLGKSENRtNKFEKGTADTFIIEAADLGVIYKIKLRHDNTKWCAD 1544
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNK-NKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1983576068 1545 WYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEK 1585
Cdd:cd01756     80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 684-805 3.48e-53

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 182.37  E-value: 3.48e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  684 FRYHISVKTGDVSGASTDSRVYIKLYGEKSDTIKQVLLVSDNnlKDYFERGRVDEFTLETLNIGTIIRLVIGHDSTGMHA 763
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNN--KNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGA 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1983576068  764 GWFLGSVQIRVPRQGKQYTFPANRWLDKNQADGRLEVELYPS 805
Cdd:cd01756     79 GWFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1828-1948 9.76e-52

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 178.13  E-value: 9.76e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1828 TSYTVSVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFpDMLSLGHLCKLRVWHDNKGIFPG 1907
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNKNKFERGQTDKFTV-EAVDLGKLKKIRIGHDNSGLGAG 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1983576068 1908 WHLSYIDVKDNSRDETFRFQCDCWLSKSEGDRQTLRDFACA 1948
Cdd:cd01756     80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 43-162 5.95e-50

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 173.12  E-value: 5.95e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068   43 KVYEVVTATGDVRGAGTDANVFITIFGENGLSPKLHL-TSKSESAFEKANVDVFRVRTNNVGLIYKIRIEHDNTGLNASW 121
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLkKSNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1983576068  122 YLDRVIVTDMKRpHLRYYFNCNNWLSKVEGDRQWCRDLLAS 162
Cdd:cd01756     81 FLDKVEIREPGT-GDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 554-675 2.01e-48

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 168.89  E-value: 2.01e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  554 RYRVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCrNNTDLFEKGNADEFTIESVTMRKVRRVRVRHDGKGSGSGW 633
Cdd:cd01756      2 TYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKS-NNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1983576068  634 YLDRVLVREEGQpeSDNVEFPCLRWLDKDKDDGQLVRELLPS 675
Cdd:cd01756     81 FLDKVEIREPGT--GDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 425-542 5.73e-46

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 161.57  E-value: 5.73e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  425 FPWSLWVWTTDLKKAGTNSPIFIQIYGKKGRTDEILLNPNNK--WFKPGIIEKFRMELPDLGRFYKIRAWHDRQNPGSGW 502
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNknKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1983576068  503 HLEKMTLMNTLNKDKYNFNCNRWLDANEDDNEIVREMTAE 542
Cdd:cd01756     81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1311-1437 3.91e-45

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 159.26  E-value: 3.91e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1311 VPYEITLYTSDVFAAGTDANVFIVIYGcDAVCTRQKFLCTNKREQKllFERKSASRFIVELEDVGEiIEKIRIGHDNTGI 1390
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYG-ENGDTGKRKLKKSNNKNK--FERGQTDKFTVEAVDLGK-LKKIRIGHDNSGL 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1983576068 1391 NPGWHCSHVDIRRLLPekdgTETLTFPCDRWLATSEDDKKTIRELVP 1437
Cdd:cd01756     77 GAGWFLDKVEIREPGT----GDEYTFPCNRWLDKDEDDGQIVRELYP 119
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 296-414 2.20e-44

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 157.33  E-value: 2.20e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  296 ITYIVTVFTGDIRGAGTKSKIYLVMYGARGNrnSGKIFLE----GGVFDRGRTDIFHIDlAVLLSPLSRVSIGHGNIGVN 371
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGD--TGKRKLKksnnKNKFERGQTDKFTVE-AVDLGKLKKIRIGHDNSGLG 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1983576068  372 RGWYCEKVVVLCPFTGIQQTFPCSNWLDEKKADGLIERQLYEM 414
Cdd:cd01756     78 AGWFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1701-1818 2.56e-44

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 156.95  E-value: 2.56e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1701 VLYEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEVQLDKK--KARFEREQNDTFIMEILDIAPFTKMRIRIDGLGSRPEW 1778
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSnnKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1983576068 1779 FLERILLKNMNTGDLTMFYYGDWLSQKKGKKTLVCEICAV 1818
Cdd:cd01756     81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 1028-1144 4.73e-30

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 116.22  E-value: 4.73e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1028 YEVQVITGNVPKAGTDANVYLTIYGEEyGDTGERPLKKSDKSnKFEQGQTDTFTI-YAIDLGALTKIRIRHDNTGNRPGW 1106
Cdd:cd01752      3 YLVTVFTGWRRGAGTTAKVTITLYGAE-GESEPHHLRDPEKP-IFERGSVDSFLLtTPFPLGELQSIRLWHDNSGLSPSW 80

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1983576068 1107 FLDRIDITDVNNETTYYFPCQRWLAVEEDDGQLSRELL 1144
Cdd:cd01752     81 YLSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFP 118
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 173-288 4.77e-30

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 116.22  E-value: 4.77e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  173 KYEIKVYTGDVIGAGTDADVFINIFGEYGDTGERRLENEKDN-FEKGAEDKFTLDAP-DLGQLMKINVGHNNKGGSAGWF 250
Cdd:cd01752      2 LYLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRDPEKPiFERGSVDSFLLTTPfPLGELQSIRLWHDNSGLSPSWY 81

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1983576068  251 LSKIIIEDIGNKRKYDFPLNRWLALDEDDGKIQRDILV 288
Cdd:cd01752     82 LSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFPV 119
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 1703-1813 6.69e-30

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 115.51  E-value: 6.69e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1703 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEVQLDKKKARFEREQNDTFIMEI-LDIAPFTKMRIRIDGLGSRPEWFLE 1781
Cdd:cd00113      3 YTVTIKTGDKKGAGTDSNISLALYGENGNSSDIPILDGPGSFERGSTDTFQIDLkLDIGDITKVYLRRDGSGLSDGWYCE 82

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1983576068 1782 RILLKNMNTGDLTMFYYGDWLSQKKGKKTLVC 1813
Cdd:cd00113     83 SITVQALGTKKVYTFPVNRWVLGGKWYTSVRS 114
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 2098-2213 8.36e-29

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 112.75  E-value: 8.36e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 2098 KYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLETLE-LGELRKVRLEHDSSGYYSGWL 2176
Cdd:cd01752      2 LYLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRDPEKPIFERGSVDSFLLTTPFpLGELQSIRLWHDNSGLSPSWY 81

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1983576068 2177 VEKVEVTNTSTGVATIFSCGRWLDKSRGDGLTWRELF 2213
Cdd:cd01752     82 LSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFP 118
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 45-154 1.63e-28

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 111.98  E-value: 1.63e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068   45 YEVVTATGDVRGAGTDANVFITIFGENGLSPKLHLTSKSESAFEKANVDVFRVRT-NNVGLIYKIRIEHDNTGLNASWYL 123
Cdd:cd01752      3 YLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRDPEKPIFERGSVDSFLLTTpFPLGELQSIRLWHDNSGLSPSWYL 82

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1983576068  124 DRVIVTDMKRPHlRYYFNCNNWLSKVEGDRQ 154
Cdd:cd01752     83 SRVIVRDLQTGK-KWFFLCNDWLSVEEGDGT 112
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 816-896 1.44e-27

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 109.18  E-value: 1.44e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  816 YEIEIWTGDVGGAGTTSRVYVQIYGEEGKTEVLFL--SSRSKVFDRGSKDIFQLEAADVGEIYKIRLGHTGEGFGPSWFV 893
Cdd:cd01756      3 YEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLkkSNNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGWFL 82


                   ...
gi 1983576068  894 DTV 896
Cdd:cd01756     83 DKV 85
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 1466-1583 3.75e-27

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 108.13  E-value: 3.75e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1466 LYSVQIFTGNVPGAGTDAKVYITIYGDLGDTGERYLGKSENRTnkFEKGTADTFIIEAA-DLGVIYKIKLRHDNTKWCAD 1544
Cdd:cd01752      2 LYLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRDPEKPI--FERGSVDSFLLTTPfPLGELQSIRLWHDNSGLSPS 79

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1983576068 1545 WYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFY 1583
Cdd:cd01752     80 WYLSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFP 118
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 1829-1948 6.98e-27

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 107.36  E-value: 6.98e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1829 SYTVSVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSaNWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPGW 1908
Cdd:cd01752      2 LYLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRDP-EKPIFERGSVDSFLLTTPFPLGELQSIRLWHDNSGLSPSW 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1983576068 1909 HLSYIDVKDNSRDETFRFQCDCWLSKSEGDRQTLRDFACA 1948
Cdd:cd01752     81 YLSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFPVA 120
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1028-1135 3.49e-24

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 99.43  E-value: 3.49e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1028 YEVQVITGNVPKAGTDANVYLTIYGEEyGDTGERPLKKSDKSnkFEQGQTDTFTIYA-IDLGALTKIRIRHDNTGNRPGW 1106
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKV-GESAQLEITLDNPD--FERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDEW 77

                           90       100       110
                   ....*....|....*....|....*....|
gi 1983576068 1107 FLDRIDIT-DVNNETTYYFPCQRWLAVEED 1135
Cdd:pfam01477   78 FLKSITVEvPGETGGKYTFPCNSWVYGSKK 107
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 1184-1300 1.27e-22

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 95.04  E-value: 1.27e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1184 VTIKTGDKKNAGTDANVFITLFGtkdNNGMTLLKS-SKTNSDKFERDSIEIFTVETL-DLGDLWKVRIGHDNTGKAPGWF 1261
Cdd:cd01752      5 VTVFTGWRRGAGTTAKVTITLYG---AEGESEPHHlRDPEKPIFERGSVDSFLLTTPfPLGELQSIRLWHDNSGLSPSWY 81

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1983576068 1262 VDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIVRDLFHA 1300
Cdd:cd01752     82 LSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFPVA 120
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 1182-1292 1.69e-22

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 94.71  E-value: 1.69e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1182 FSVTIKTGDKKNAGTDANVFITLFGTkdnNGMTLLKSSKTNSDKFERDSIEIFTVET-LDLGDLWKVRIGHDNTGKAPGW 1260
Cdd:cd00113      3 YTVTIKTGDKKGAGTDSNISLALYGE---NGNSSDIPILDGPGSFERGSTDTFQIDLkLDIGDITKVYLRRDGSGLSDGW 79

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1983576068 1261 FVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGS 1292
Cdd:cd00113     80 YCESITVQALGTKKVYTFPVNRWVLGGKWYTS 111
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 1028-1130 2.07e-20

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 88.55  E-value: 2.07e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1028 YEVQVITGNVPKAGTDANVYLTIYGEeYGDTGERPLkkSDKSNKFEQGQTDTFTIYA-IDLGALTKIRIRHDNTGNRPGW 1106
Cdd:cd00113      3 YTVTIKTGDKKGAGTDSNISLALYGE-NGNSSDIPI--LDGPGSFERGSTDTFQIDLkLDIGDITKVYLRRDGSGLSDGW 79

                           90       100
                   ....*....|....*....|....
gi 1983576068 1107 FLDRIDITDVNNETTYYFPCQRWL 1130
Cdd:cd00113     80 YCESITVQALGTKKVYTFPVNRWV 103
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 174-273 2.40e-20

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 88.26  E-value: 2.40e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  174 YEIKVYTGDVIGAGTDADVFINIFGEYGDTGERRLENEKDNFEKGAEDKFTLDAP-DLGQLMKINVGHNNKGGSAGWFLS 252
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGAEDSFEIDTDwDVGAILKINLHWDNNGLSDEWFLK 80

                           90       100
                   ....*....|....*....|..
gi 1983576068  253 KIIIEDIG-NKRKYDFPLNRWL 273
Cdd:pfam01477   81 SITVEVPGeTGGKYTFPCNSWV 102
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 1830-1941 2.74e-20

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 88.16  E-value: 2.74e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1830 YTVSVKTSDILGAGTDANVFIIIFGENGDSGTLalKQSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPGWH 1909
Cdd:cd00113      3 YTVTIKTGDKKGAGTDSNISLALYGENGNSSDI--PILDGPGSFERGSTDTFQIDLKLDIGDITKVYLRRDGSGLSDGWY 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1983576068 1910 LSYIDVKDNSRDETFRFQCDCWLSKSEGDRQT 1941
Cdd:cd00113     81 CESITVQALGTKKVYTFPVNRWVLGGKWYTSV 112
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1830-1942 3.06e-20

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 87.87  E-value: 3.06e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1830 YTVSVKTSDILGAGTDANVFIIIFGENGDSGTLALKQsaNWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPGWH 1909
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITL--DNPDFERGAEDSFEIDTDWDVGAILKINLHWDNNGLSDEWF 78

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1983576068 1910 LSYIDVKDNSRDE-TFRFQCDCWLSKSEGDRQTL 1942
Cdd:pfam01477   79 LKSITVEVPGETGgKYTFPCNSWVYGSKKYKETR 112
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1182-1289 1.05e-19

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 86.72  E-value: 1.05e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1182 FSVTIKTGDKKNAGTDANVFITLFGTKDNngMTLLKSSKTNSDkFERDSIEIFTVET-LDLGDLWKVRIGHDNTGKAPGW 1260
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGE--SAQLEITLDNPD-FERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDEW 77

                           90       100       110
                   ....*....|....*....|....*....|
gi 1983576068 1261 FVDWVEVDAPSL-GKCMTFPCGRWLAKNED 1289
Cdd:pfam01477   78 FLKSITVEVPGEtGGKYTFPCNSWVYGSKK 107
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 298-402 1.26e-19

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 86.33  E-value: 1.26e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  298 YIVTVFTGDIRGAGTKSKIYLVMYGARGNRNSGKIFLEGGVFDRGRTDIFHIDLAVLLSPLSRVSIGHGNIGVNRGWYCE 377
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGAEDSFEIDTDWDVGAILKINLHWDNNGLSDEWFLK 80

                           90       100
                   ....*....|....*....|....*.
gi 1983576068  378 KVVVLCP-FTGIQQTFPCSNWLDEKK 402
Cdd:pfam01477   81 SITVEVPgETGGKYTFPCNSWVYGSK 106
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 684-803 1.35e-19

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 86.56  E-value: 1.35e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  684 FRYHISVKTGDVSGASTDSRVYIKLYGEKSDTIKQVLLVSDnnlKDYFERGRVDEFTLETL-NIGTIIRLVIGHDSTGMH 762
Cdd:cd01752      1 YLYLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRDPE---KPIFERGSVDSFLLTTPfPLGELQSIRLWHDNSGLS 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1983576068  763 AGWFLGSVQIRVPRQGKQYTFPANRWLDKNQADGRLEVELY 803
Cdd:cd01752     78 PSWYLSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFP 118
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 1313-1435 2.16e-19

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 85.79  E-value: 2.16e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1313 YEITLYTSDVFAAGTDANVFIVIYGCDAVCTRQKFLCTNKReqklLFERKSASRFIVE-LEDVGEIiEKIRIGHDNTGIN 1391
Cdd:cd01752      3 YLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRDPEKP----IFERGSVDSFLLTtPFPLGEL-QSIRLWHDNSGLS 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1983576068 1392 PGWHCSHVDIRRLLPEKdgteTLTFPCDRWLATSEDDKKTIREL 1435
Cdd:cd01752     78 PSWYLSRVIVRDLQTGK----KWFFLCNDWLSVEEGDGTVERTF 117
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 45-148 2.54e-19

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 85.56  E-value: 2.54e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068   45 YEVVTATGDVRGAGTDANVFITIFGENGLSPKLHLTSKSESaFEKANVDVFRVRT-NNVGLIYKIRIEHDNTGLNASWYL 123
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPD-FERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDEWFL 79

                           90       100
                   ....*....|....*....|....*
gi 1983576068  124 DRVIVTDMKRPHLRYYFNCNNWLSK 148
Cdd:pfam01477   80 KSITVEVPGETGGKYTFPCNSWVYG 104
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 815-906 4.43e-19

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 85.02  E-value: 4.43e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  815 HYEIEIWTGDVGGAGTTSRVYVQIYGEEGKTEV-LFLSSRSKVFDRGSKDIFQLEAA-DVGEIYKIRLGHTGEGFGPSWF 892
Cdd:cd01752      2 LYLVTVFTGWRRGAGTTAKVTITLYGAEGESEPhHLRDPEKPIFERGSVDSFLLTTPfPLGELQSIRLWHDNSGLSPSWY 81

                           90
                   ....*....|....
gi 1983576068  893 VDTVWLRHLVVQEE 906
Cdd:cd01752     82 LSRVIVRDLQTGKK 95
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 173-280 5.30e-19

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 84.70  E-value: 5.30e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  173 KYEIKVYTGDVIGAGTDADVFINIFGEYGDTGERRLENEKDNFEKGAEDKFTLDAP-DLGQLMKINVGHNNKGGSAGWFL 251
Cdd:cd00113      2 RYTVTIKTGDKKGAGTDSNISLALYGENGNSSDIPILDGPGSFERGSTDTFQIDLKlDIGDITKVYLRRDGSGLSDGWYC 81

                           90       100
                   ....*....|....*....|....*....
gi 1983576068  252 SKIIIEDIGNKRKYDFPLNRWLALDEDDG 280
Cdd:cd00113     82 ESITVQALGTKKVYTFPVNRWVLGGKWYT 110
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 2098-2208 8.96e-19

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 83.93  E-value: 8.96e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 2098 KYEVIVTTGYEPGAGTDANVFVTIFGANGdtgKRELKQKMRNL--FERGSTDRFFLET-LELGELRKVRLEHDSSGYYSG 2174
Cdd:cd00113      2 RYTVTIKTGDKKGAGTDSNISLALYGENG---NSSDIPILDGPgsFERGSTDTFQIDLkLDIGDITKVYLRRDGSGLSDG 78

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1983576068 2175 WLVEKVEVTNTSTGVATIFSCGRWLDKSRGDGLT 2208
Cdd:cd00113     79 WYCESITVQALGTKKVYTFPVNRWVLGGKWYTSV 112
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 298-400 1.18e-18

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 83.54  E-value: 1.18e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  298 YIVTVFTGDIRGAGTKSKIYLVMYGARGNRNSGKIFLEGGVFDRGRTDIFHIDLAVLLSPLSRVSIGHGNIGVNRGWYCE 377
Cdd:cd00113      3 YTVTIKTGDKKGAGTDSNISLALYGENGNSSDIPILDGPGSFERGSTDTFQIDLKLDIGDITKVYLRRDGSGLSDGWYCE 82

                           90       100
                   ....*....|....*....|...
gi 1983576068  378 KVVVLCPFTGIQQTFPCSNWLDE 400
Cdd:cd00113     83 SITVQALGTKKVYTFPVNRWVLG 105
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 43-148 2.76e-18

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 82.39  E-value: 2.76e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068   43 KVYEVVTATGDVRGAGTDANVFITIFGENGLSPKLHLTSKSESaFEKANVDVFRVRT-NNVGLIYKIRIEHDNTGLNASW 121
Cdd:cd00113      1 CRYTVTIKTGDKKGAGTDSNISLALYGENGNSSDIPILDGPGS-FERGSTDTFQIDLkLDIGDITKVYLRRDGSGLSDGW 79

                           90       100
                   ....*....|....*....|....*..
gi 1983576068  122 YLDRVIVTDMKRPHlRYYFNCNNWLSK 148
Cdd:cd00113     80 YCESITVQALGTKK-VYTFPVNRWVLG 105
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 2099-2208 3.94e-18

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 82.09  E-value: 3.94e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 2099 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKmRNLFERGSTDRFFLET-LELGELRKVRLEHDSSGYYSGWLV 2177
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLD-NPDFERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDEWFL 79

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1983576068 2178 EKVEVT-NTSTGVATIFSCGRWLDKSRGDGLT 2208
Cdd:pfam01477   80 KSITVEvPGETGGKYTFPCNSWVYGSKKYKET 111
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 686-793 5.98e-18

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 81.71  E-value: 5.98e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  686 YHISVKTGDVSGASTDSRVYIKLYGEKSDTIKQVLLVSDNNlkdyFERGRVDEFTLET-LNIGTIIRLVIGHDSTGMHAG 764
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPD----FERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDE 76

                           90       100       110
                   ....*....|....*....|....*....|
gi 1983576068  765 WFLGSVQIRVPRQ-GKQYTFPANRWLDKNQ 793
Cdd:pfam01477   77 WFLKSITVEVPGEtGGKYTFPCNSWVYGSK 106
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1467-1582 1.00e-17

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 80.94  E-value: 1.00e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1467 YSVQIFTGNVPGAGTDAKVYITIYGDLGDTGERYLGKSENRtnkFEKGTADTFII-EAADLGVIYKIKLRHDNTKWCADW 1545
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPD---FERGAEDSFEIdTDWDVGAILKINLHWDNNGLSDEW 77

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1983576068 1546 YVEKVEIW-NDTNEDEFLFLCGRWLSlKKEDGRLERLF 1582
Cdd:pfam01477   78 FLKSITVEvPGETGGKYTFPCNSWVY-GSKKYKETRVF 114
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 685-792 7.15e-17

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 78.53  E-value: 7.15e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  685 RYHISVKTGDVSGASTDSRVYIKLYGEKSDTiKQVLLVSDNnlkDYFERGRVDEFTLET-LNIGTIIRLVIGHDSTGMHA 763
Cdd:cd00113      2 RYTVTIKTGDKKGAGTDSNISLALYGENGNS-SDIPILDGP---GSFERGSTDTFQIDLkLDIGDITKVYLRRDGSGLSD 77

                           90       100
                   ....*....|....*....|....*....
gi 1983576068  764 GWFLGSVQIRVPRQGKQYTFPANRWLDKN 792
Cdd:cd00113     78 GWYCESITVQALGTKKVYTFPVNRWVLGG 106
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 298-412 1.02e-16

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 78.09  E-value: 1.02e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  298 YIVTVFTGDIRGAGTKSKIYLVMYGARGnrNSGKIFLEGG---VFDRGRTDIFHIDLAVLLSPLSRVSIGHGNIGVNRGW 374
Cdd:cd01752      3 YLVTVFTGWRRGAGTTAKVTITLYGAEG--ESEPHHLRDPekpIFERGSVDSFLLTTPFPLGELQSIRLWHDNSGLSPSW 80

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1983576068  375 YCEKVVVLCPFTGIQQTFPCSNWLDEKKADGLIERQLY 412
Cdd:cd01752     81 YLSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFP 118
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 1467-1582 9.94e-16

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 75.07  E-value: 9.94e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1467 YSVQIFTGNVPGAGTDAKVYITIYGDLGDTGErylGKSENRTNKFEKGTADTFIIEAA-DLGVIYKIKLRHDNTKWCADW 1545
Cdd:cd00113      3 YTVTIKTGDKKGAGTDSNISLALYGENGNSSD---IPILDGPGSFERGSTDTFQIDLKlDIGDITKVYLRRDGSGLSDGW 79

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1983576068 1546 YVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLF 1582
Cdd:cd00113     80 YCESITVQALGTKKVYTFPVNRWVLGGKWYTSVRSLK 116
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 426-533 1.06e-15

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 75.07  E-value: 1.06e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  426 PWSLWVWTTDLKKAGTNSPIFIQIYGKKGRTDEILLNPNNKWFKPGIIEKFRMELP-DLGRFYKIRAWHDRQNPGSGWHL 504
Cdd:cd00113      2 RYTVTIKTGDKKGAGTDSNISLALYGENGNSSDIPILDGPGSFERGSTDTFQIDLKlDIGDITKVYLRRDGSGLSDGWYC 81

                           90       100
                   ....*....|....*....|....*....
gi 1983576068  505 EKMTLMNTLNKDKYNFNCNRWLDANEDDN 533
Cdd:cd00113     82 ESITVQALGTKKVYTFPVNRWVLGGKWYT 110
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 427-534 1.26e-15

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 74.78  E-value: 1.26e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  427 WSLWVWTTDLKKAGTNSPIFIQIYGKKGRTDEILLNPNNKWFKPGIIEKFRMELP-DLGRFYKIRAWHDRQNPGSGWHLE 505
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGAEDSFEIDTDwDVGAILKINLHWDNNGLSDEWFLK 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 1983576068  506 KMTLM-NTLNKDKYNFNCNRWLDANEDDNE 534
Cdd:pfam01477   81 SITVEvPGETGGKYTFPCNSWVYGSKKYKE 110
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 1702-1817 1.75e-15

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 74.62  E-value: 1.75e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1702 LYEMTVWTGDVVGGGTDSNIFMTLYGINGSTE-EVQLDKKKARFEREQNDTFIMEildiAPF-----TKMRIRIDGLGSR 1775
Cdd:cd01752      2 LYLVTVFTGWRRGAGTTAKVTITLYGAEGESEpHHLRDPEKPIFERGSVDSFLLT----TPFplgelQSIRLWHDNSGLS 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1983576068 1776 PEWFLERILLKNMNTGDLTMFYYGDWLSQKKGKKTLVCEICA 1817
Cdd:cd01752     78 PSWYLSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFPV 119
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
173-273 1.80e-14

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 71.13  E-value: 1.80e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068   173 KYEIKVYTGDVIGAGTDADVFINIFGEYGDTGERRL-ENEKDNFEKGAEDKFTLDAP-DLGQLMKINVgHNNKGGSAgWF 250
Cdd:smart00308    2 KYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLdYLFKGIFARGSTYEFTFDVDeDFGELGAVKI-KNEHRHPE-WF 79

                            90       100
                    ....*....|....*....|...
gi 1983576068   251 LSKIIIEDIGNKRKYDFPLNRWL 273
Cdd:smart00308   80 LKSITVKDLPTGGKYHFPCNSWV 102
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 437-542 2.22e-14

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 71.54  E-value: 2.22e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  437 KKAGTNSPIFIQIYGKKGRTD-EILLNPNNKWFKPGIIEKFRMELP-DLGRFYKIRAWHDRQNPGSGWHLEKMTLMNTLN 514
Cdd:cd01752     13 RGAGTTAKVTITLYGAEGESEpHHLRDPEKPIFERGSVDSFLLTTPfPLGELQSIRLWHDNSGLSPSWYLSRVIVRDLQT 92

                           90       100
                   ....*....|....*....|....*...
gi 1983576068  515 KDKYNFNCNRWLDANEDDNEIVREMTAE 542
Cdd:cd01752     93 GKKWFFLCNDWLSVEEGDGTVERTFPVA 120
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 815-896 3.94e-14

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 70.83  E-value: 3.94e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  815 HYEIEIWTGDVGGAGTTSRVYVQIYGEEGKTEVLFLSSRSKVFDRGSKDIFQLEAA-DVGEIYKIRLGHTGEGFGPSWFV 893
Cdd:cd00113      2 RYTVTIKTGDKKGAGTDSNISLALYGENGNSSDIPILDGPGSFERGSTDTFQIDLKlDIGDITKVYLRRDGSGLSDGWYC 81


                   ...
gi 1983576068  894 DTV 896
Cdd:cd00113     82 ESI 84
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 816-899 1.02e-13

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 69.38  E-value: 1.02e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  816 YEIEIWTGDVGGAGTTSRVYVQIYGEEGKTEVLFLSSRSKVFDRGSKDIFQL-EAADVGEIYKIRLGHTGEGFGPSWFVD 894
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGAEDSFEIdTDWDVGAILKINLHWDNNGLSDEWFLK 80


                   ....*
gi 1983576068  895 TVWLR 899
Cdd:pfam01477   81 SITVE 85
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1028-1130 1.05e-13

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 69.21  E-value: 1.05e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  1028 YEVQVITGNVPKAGTDANVYLTIYGEEyGDTGERPLKKSDKsNKFEQGQTDTFTI-YAIDLGALTKIRIRHDNtgNRPGW 1106
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAE-GDGKESKLDYLFK-GIFARGSTYEFTFdVDEDFGELGAVKIKNEH--RHPEW 78

                            90       100
                    ....*....|....*....|....
gi 1983576068  1107 FLDRIDITDVNNETTYYFPCQRWL 1130
Cdd:smart00308   79 FLKSITVKDLPTGGKYHFPCNSWV 102
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 1182-1291 1.05e-13

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 69.49  E-value: 1.05e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1182 FSVTIKTGDK-KNAGTDANVFITLFGTKDNNGMTLLKssktnsdkfeRDSIEiFTVETLDLGDLWKVRIGHDNTGKAPGW 1260
Cdd:cd01757      3 YHVVIVPSKKlGGSMFTANPWICVSGELGETPPLQIP----------KNSLE-MTFDCQNLGKLTTVQIGHDNSGLLAKW 71

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1983576068 1261 FVDWVEVDAPSLGKCMTFPCGRWLAKNEDDG 1291
Cdd:cd01757     72 LVEYVMVRNEITGHTYKFPCGRWLGEGVDDG 102
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 2101-2208 1.64e-13

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 68.72  E-value: 1.64e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 2101 VIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKqkmRNLFErgstdrFFLETLELGELRKVRLEHDSSGYYSGWLVEKV 2180
Cdd:cd01757      6 VIVPSKKLGGSMFTANPWICVSGELGETPPLQIP---KNSLE------MTFDCQNLGKLTTVQIGHDNSGLLAKWLVEYV 76

                           90       100
                   ....*....|....*....|....*...
gi 1983576068 2181 EVTNTSTGVATIFSCGRWLDKSRGDGLT 2208
Cdd:cd01757     77 MVRNEITGHTYKFPCGRWLGEGVDDGNG 104
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1313-1431 1.80e-13

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 68.61  E-value: 1.80e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1313 YEITLYTSDVFAAGTDANVFIVIYGCDAVCTRQKFLCTNKReqkllFERKSASRFIVELE-DVGEIIeKIRIGHDNTGIN 1391
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPD-----FERGAEDSFEIDTDwDVGAIL-KINLHWDNNGLS 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1983576068 1392 PGWHCSHVdirRLLPEKDGTETLTFPCDRWLATSEDDKKT 1431
Cdd:pfam01477   75 DEWFLKSI---TVEVPGETGGKYTFPCNSWVYGSKKYKET 111
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 554-670 2.42e-13

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 68.52  E-value: 2.42e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  554 RYRVTVCTGELEGAGTDANVYLCLFGDVGDTGErllYNCRNNTDLFEKGNADEFTIE-SVTMRKVRRVRVRHDGKGSGSG 632
Cdd:cd00113      2 RYTVTIKTGDKKGAGTDSNISLALYGENGNSSD---IPILDGPGSFERGSTDTFQIDlKLDIGDITKVYLRRDGSGLSDG 78

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1983576068  633 WYLDRVLVREEGqpESDNVEFPCLRWLDKDKDDGQLVR 670
Cdd:cd00113     79 WYCESITVQALG--TKKVYTFPVNRWVLGGKWYTSVRS 114
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1703-1810 2.99e-13

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 68.23  E-value: 2.99e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1703 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEVQLDKKKARFEREQNDTFIMEI-LDIAPFTKMRIRIDGLGSRPEWFLE 1781
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDEWFLK 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 1983576068 1782 RILL-KNMNTGDLTMFYYGDWLSQKKGKKT 1810
Cdd:pfam01477   81 SITVeVPGETGGKYTFPCNSWVYGSKKYKE 110
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1184-1287 3.30e-13

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 67.67  E-value: 3.30e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  1184 VTIKTGDKKNAGTDANVFITLFGTKDNNGMTLLKSSKTNSdkFERDSIEIFTVET-LDLGDLWKVRIGHDNtgKAPGWFV 1262
Cdd:smart00308    5 VTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGI--FARGSTYEFTFDVdEDFGELGAVKIKNEH--RHPEWFL 80

                            90       100
                    ....*....|....*....|....*
gi 1983576068  1263 DWVEVDAPSLGKCMTFPCGRWLAKN 1287
Cdd:smart00308   81 KSITVKDLPTGGKYHFPCNSWVYPD 105
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 685-790 4.54e-13

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 67.33  E-value: 4.54e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  685 RYHISVKTGDVSGASTDSRVYIKLYGEKSDTIKQVLLvsdnNLKDYFERGRVDEFTLE-TLNIGTIIRLVIGHDSTGMHA 763
Cdd:cd01753      2 EYKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLD----RPGYDFERGAVDEYKVKvPEDLGELLLVRLRKRKYLLFD 77

                           90       100
                   ....*....|....*....|....*..
gi 1983576068  764 GWFLGSVQIRVPRQGKqYTFPANRWLD 790
Cdd:cd01753     78 AWFCNYITVTGPGGDE-YHFPCYRWIE 103
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 555-664 6.01e-13

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 67.07  E-value: 6.01e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  555 YRVTVCTGELEGAGTDANVYLCLFGDVGDTGerLLYNCRNNTDlFEKGNADEFTI-ESVTMRKVRRVRVRHDGKGSGSGW 633
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESA--QLEITLDNPD-FERGAEDSFEIdTDWDVGAILKINLHWDNNGLSDEW 77

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1983576068  634 YLDRVLVREEGQPESdNVEFPCLRWLDKDKD 664
Cdd:pfam01477   78 FLKSITVEVPGETGG-KYTFPCNSWVYGSKK 107
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 554-673 7.82e-13

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 66.92  E-value: 7.82e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  554 RYRVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNcrNNTDLFEKGNADEF---------TIESVTMrkvrrvrvRH 624
Cdd:cd01752      2 LYLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRD--PEKPIFERGSVDSFllttpfplgELQSIRL--------WH 71

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1983576068  625 DGKGSGSGWYLDRVLVREegqPESDNV-EFPCLRWLDKDKDDGQLVRELL 673
Cdd:cd01752     72 DNSGLSPSWYLSRVIVRD---LQTGKKwFFLCNDWLSVEEGDGTVERTFP 118
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
2098-2201 1.38e-12

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 65.74  E-value: 1.38e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  2098 KYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLET-LELGELRKVRLEHDssGYYSGWL 2176
Cdd:smart00308    2 KYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGIFARGSTYEFTFDVdEDFGELGAVKIKNE--HRHPEWF 79

                            90       100
                    ....*....|....*....|....*
gi 1983576068  2177 VEKVEVTNTSTGVATIFSCGRWLDK 2201
Cdd:smart00308   80 LKSITVKDLPTGGKYHFPCNSWVYP 104
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 686-798 2.38e-12

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 66.03  E-value: 2.38e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  686 YHISVKTGDVSGASTDSRVYIKLYGEKSDTIKQVLLVSDNNLK----DYFERGRVDEFT--LETLNiGTIIRLVIGHDST 759
Cdd:cd01754      3 YTIYVQTGSIWKAGTDSRISLQIYDADGPGLRIANLEAWGGLMgaghDYFERGNLDRFSgrGPCLP-SPPCWMNLTSDGT 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1983576068  760 GMHAGWFLGSVQIRVPRQGK---QYTFPANRWLDKNQADGRL 798
Cdd:cd01754     82 GNHPGWYVNYVEVTQAGQHApcmQHLFAVEQWLATDESPYML 123
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 1830-1936 5.96e-12

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 64.87  E-value: 5.96e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1830 YTVSVKTSDILGAGTDANVFIIIFGENGDSGTLALKQS------ANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKG 1903
Cdd:cd01754      3 YTIYVQTGSIWKAGTDSRISLQIYDADGPGLRIANLEAwgglmgAGHDYFERGNLDRFSGRGPCLPSPPCWMNLTSDGTG 82

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1983576068 1904 IFPGWHLSYIDVK---DNSRDETFRFQCDCWLSKSE 1936
Cdd:cd01754     83 NHPGWYVNYVEVTqagQHAPCMQHLFAVEQWLATDE 118
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 1312-1422 1.61e-11

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 63.13  E-value: 1.61e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1312 PYEITLYTSDVFAAGTDANVFIVIYGcdAVCTRQKFLCTNKreqKLLFERKSASRFIVELE-DVGeIIEKIRIGHDNTGI 1390
Cdd:cd00113      2 RYTVTIKTGDKKGAGTDSNISLALYG--ENGNSSDIPILDG---PGSFERGSTDTFQIDLKlDIG-DITKVYLRRDGSGL 75

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1983576068 1391 NPGWHCSHVDIRRLlpekDGTETLTFPCDRWL 1422
Cdd:cd00113     76 SDGWYCESITVQAL----GTKKVYTFPVNRWV 103
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 1181-1294 2.24e-11

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 62.71  E-value: 2.24e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1181 TFSVTIKTGDKKNAGTDANVFITLFGTKDNNGMTLLKSSKTNsdkFERDSIEIFTVE-TLDLGDLWKVRIGHDNTGKAPG 1259
Cdd:cd01753      2 EYKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLDRPGYD---FERGAVDEYKVKvPEDLGELLLVRLRKRKYLLFDA 78

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1983576068 1260 WFVDWVEVDAPSlGKCMTFPCGRWLaknEDDGSIV 1294
Cdd:cd01753     79 WFCNYITVTGPG-GDEYHFPCYRWI---EGYGTLE 109
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 173-280 2.66e-11

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 62.33  E-value: 2.66e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  173 KYEIKVYTGDVIGAGTDADVFINIFGEYGDTGERRLENEKDNFEKGAEDKFTLDAP-DLGQLMKINVgHNNKGGS-AGWF 250
Cdd:cd01753      2 EYKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLDRPGYDFERGAVDEYKVKVPeDLGELLLVRL-RKRKYLLfDAWF 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 1983576068  251 LSKIIIEDIGNkRKYDFPLNRWLaldEDDG 280
Cdd:cd01753     81 CNYITVTGPGG-DEYHFPCYRWI---EGYG 106
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 1027-1140 1.07e-10

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 60.79  E-value: 1.07e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1027 TYEVQVITGNVPKAGTDANVYLTIYGEEygdtGERPLKKSDKSNK-FEQGQTDTFTIYA-IDLGALTKIRIRHDNTGNRP 1104
Cdd:cd01753      2 EYKVTVATGSSLFAGTDDYIYLTLVGTA----GESEKQLLDRPGYdFERGAVDEYKVKVpEDLGELLLVRLRKRKYLLFD 77

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1983576068 1105 GWFLDRIDITdVNNETTYYFPCQRWLaveEDDGQLS 1140
Cdd:cd01753     78 AWFCNYITVT-GPGGDEYHFPCYRWI---EGYGTLE 109
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
431-527 1.08e-10

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 60.35  E-value: 1.08e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068   431 VWTTDLKKAGTNSPIFIQIYGKKGRTDEILLNPNNKW-FKPGIIEKFRMELP-DLGRFYKIRAWHdrQNPGSGWHLEKMT 508
Cdd:smart00308    7 VTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGiFARGSTYEFTFDVDeDFGELGAVKIKN--EHRHPEWFLKSIT 84

                            90
                    ....*....|....*....
gi 1983576068   509 LMNTLNKDKYNFNCNRWLD 527
Cdd:smart00308   85 VKDLPTGGKYHFPCNSWVY 103
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 1181-1288 1.26e-10

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 61.02  E-value: 1.26e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1181 TFSVTIKTGDKKNAGTDANVFITLFGtKDNNGMTL--LKS----SKTNSDKFERDSIEIFTVETLDL-GDLWKVRIGHDN 1253
Cdd:cd01754      2 VYTIYVQTGSIWKAGTDSRISLQIYD-ADGPGLRIanLEAwgglMGAGHDYFERGNLDRFSGRGPCLpSPPCWMNLTSDG 80

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1983576068 1254 TGKAPGWFVDWVEVDAPSLGK-CMT--FPCGRWLAKNE 1288
Cdd:cd01754     81 TGNHPGWYVNYVEVTQAGQHApCMQhlFAVEQWLATDE 118
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 43-152 1.62e-10

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 60.40  E-value: 1.62e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068   43 KVYEVVTATGDVRGAGTDANVFITIFGENGLSPKlHLTSKSESAFEKANVDVFRVR-TNNVGLIYKIRIEHDNTGLNASW 121
Cdd:cd01753      1 AEYKVTVATGSSLFAGTDDYIYLTLVGTAGESEK-QLLDRPGYDFERGAVDEYKVKvPEDLGELLLVRLRKRKYLLFDAW 79

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1983576068  122 YLDRVIVTDmkrPHLRYY-FNCNNWlskVEGD 152
Cdd:cd01753     80 FCNYITVTG---PGGDEYhFPCYRW---IEGY 105
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 44-150 2.60e-10

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 60.25  E-value: 2.60e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068   44 VYEVVTATGDVRGAGTDANVFITIFGENG-------LSPKLHLTSKSESAFEKANVDVFRVRTNNV-GLIYKIRIEHDNT 115
Cdd:cd01754      2 VYTIYVQTGSIWKAGTDSRISLQIYDADGpglrianLEAWGGLMGAGHDYFERGNLDRFSGRGPCLpSPPCWMNLTSDGT 81

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1983576068  116 GLNASWYLDRVIVTdMKRPHLR---YYFNCNNWLSKVE 150
Cdd:cd01754     82 GNHPGWYVNYVEVT-QAGQHAPcmqHLFAVEQWLATDE 118
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 174-277 2.87e-10

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 60.25  E-value: 2.87e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  174 YEIKVYTGDVIGAGTDADVFINIFGEYGDTGE-RRLEN-------EKDNFEKGAEDKFTLDAPDL-GQLMKINVGHNNKG 244
Cdd:cd01754      3 YTIYVQTGSIWKAGTDSRISLQIYDADGPGLRiANLEAwgglmgaGHDYFERGNLDRFSGRGPCLpSPPCWMNLTSDGTG 82

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1983576068  245 GSAGWFLSKIIIEDIGNKR---KYDFPLNRWLALDE 277
Cdd:cd01754     83 NHPGWYVNYVEVTQAGQHApcmQHLFAVEQWLATDE 118
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 1028-1144 3.21e-10

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 59.47  E-value: 3.21e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1028 YEVQVITGN-VPKAGTDANVYLTIYGEeYGDTGERPLKKsdksNKFEqgqtdtFTIYAIDLGALTKIRIRHDNTGNRPGW 1106
Cdd:cd01757      3 YHVVIVPSKkLGGSMFTANPWICVSGE-LGETPPLQIPK----NSLE------MTFDCQNLGKLTTVQIGHDNSGLLAKW 71

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1983576068 1107 FLDRIDITDVNNETTYYFPCQRWLA-----VEEDDGQLSRELL 1144
Cdd:cd01757     72 LVEYVMVRNEITGHTYKFPCGRWLGegvddGNGEDGSLERVLV 114
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 686-799 5.53e-10

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 58.70  E-value: 5.53e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  686 YHISVKTGD-VSGASTDSRVYIKLYGEKSDTikQVLLVSDNNLkdyfergrvdEFTLETLNIGTIIRLVIGHDSTGMHAG 764
Cdd:cd01757      3 YHVVIVPSKkLGGSMFTANPWICVSGELGET--PPLQIPKNSL----------EMTFDCQNLGKLTTVQIGHDNSGLLAK 70

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1983576068  765 WFLGSVQIRVPRQGKQYTFPANRWL-----DKNQADGRLE 799
Cdd:cd01757     71 WLVEYVMVRNEITGHTYKFPCGRWLgegvdDGNGEDGSLE 110
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
684-792 5.57e-10

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 58.42  E-value: 5.57e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068   684 FRYHISVKTGDVSGASTDSRVYIKLYGEKSDTIKQVLlvsDNNLKDYFERGRVDEFTLET-LNIGTI--IRLVIGHDstg 760
Cdd:smart00308    1 GKYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKL---DYLFKGIFARGSTYEFTFDVdEDFGELgaVKIKNEHR--- 74

                            90       100       110
                    ....*....|....*....|....*....|..
gi 1983576068   761 mHAGWFLGSVQIRVPRQGKQYTFPANRWLDKN 792
Cdd:smart00308   75 -HPEWFLKSITVKDLPTGGKYHFPCNSWVYPD 105
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 1027-1140 5.92e-10

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 59.09  E-value: 5.92e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1027 TYEVQVITGNVPKAGTDANVYLTIYGEEyGDTG-----ER--PLKKSDKsNKFEQGQTDTFTIYAIDL-GALTKIRIRHD 1098
Cdd:cd01754      2 VYTIYVQTGSIWKAGTDSRISLQIYDAD-GPGLrianlEAwgGLMGAGH-DYFERGNLDRFSGRGPCLpSPPCWMNLTSD 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1983576068 1099 NTGNRPGWFLDRIDITDVNNE---TTYYFPCQRWLAVEEDDGQLS 1140
Cdd:cd01754     80 GTGNHPGWYVNYVEVTQAGQHapcMQHLFAVEQWLATDESPYMLT 124
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 2097-2206 8.71e-10

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 58.09  E-value: 8.71e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 2097 VKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNlFERGSTDRFFLE-TLELGELRKVRLEHDSSGYYSGW 2175
Cdd:cd01753      1 AEYKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLDRPGYD-FERGAVDEYKVKvPEDLGELLLVRLRKRKYLLFDAW 79

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1983576068 2176 LVEKVEVTNTSTGVATiFSCGRWLDksrGDG 2206
Cdd:cd01753     80 FCNYITVTGPGGDEYH-FPCYRWIE---GYG 106
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 553-663 2.66e-09

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 56.93  E-value: 2.66e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  553 ARYRVTVCTGELEGAGTDANVYLCLfgdVGDTGERLLYNCRNNTDLFEKGNADEFTIESVTMRKVRRVRVRHDGK-GSGS 631
Cdd:cd01753      1 AEYKVTVATGSSLFAGTDDYIYLTL---VGTAGESEKQLLDRPGYDFERGAVDEYKVKVPEDLGELLLVRLRKRKyLLFD 77

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1983576068  632 GWYLDRVLVREegqPESDNVEFPCLRWLDKDK 663
Cdd:cd01753     78 AWFCNYITVTG---PGGDEYHFPCYRWIEGYG 106
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 297-399 2.71e-09

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 56.55  E-value: 2.71e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  297 TYIVTVFTGDIRGAGTKSKIYLVMYGARGNRNSGKIFLEGGVFDRGRTDIFHIDLAVLLSPLSRVSIGHGNIGVNRGWYC 376
Cdd:cd01753      2 EYKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLDRPGYDFERGAVDEYKVKVPEDLGELLLVRLRKRKYLLFDAWFC 81

                           90       100
                   ....*....|....*....|...
gi 1983576068  377 EKVVVLCPFTGIqQTFPCSNWLD 399
Cdd:cd01753     82 NYITVTGPGGDE-YHFPCYRWIE 103
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 297-398 4.70e-09

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 56.40  E-value: 4.70e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  297 TYIVTVFTGDIRGAGTKSKIYLVMYGARGnRNSGKIFLE--GGV-------FDRGRTDIFHIDLAVLLSPLSRVSIGHGN 367
Cdd:cd01754      2 VYTIYVQTGSIWKAGTDSRISLQIYDADG-PGLRIANLEawGGLmgaghdyFERGNLDRFSGRGPCLPSPPCWMNLTSDG 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1983576068  368 IGVNRGWYCEKVVVLCpfTGI-----QQTFPCSNWL 398
Cdd:cd01754     81 TGNHPGWYVNYVEVTQ--AGQhapcmQHLFAVEQWL 114
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 1313-1426 6.85e-09

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 56.01  E-value: 6.85e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1313 YEITLYTSDVFAAGTDANVFIVIYGCDAVCTRQKFLctnKREQKLL------FERKSASRFIVELEDVGEIIEKIRIGHD 1386
Cdd:cd01754      3 YTIYVQTGSIWKAGTDSRISLQIYDADGPGLRIANL---EAWGGLMgaghdyFERGNLDRFSGRGPCLPSPPCWMNLTSD 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1983576068 1387 NTGINPGWHCSHVDIrRLLPEKDGTETLTFPCDRWLATSE 1426
Cdd:cd01754     80 GTGNHPGWYVNYVEV-TQAGQHAPCMQHLFAVEQWLATDE 118
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 1465-1581 1.32e-08

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 54.85  E-value: 1.32e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1465 VLYSVQIFTGN-VPGAGTDAKVYITIYGDLGDTGERYLGKsenrtNKFEkgtadtFIIEAADLGVIYKIKLRHDNTKWCA 1543
Cdd:cd01757      1 MPYHVVIVPSKkLGGSMFTANPWICVSGELGETPPLQIPK-----NSLE------MTFDCQNLGKLTTVQIGHDNSGLLA 69

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1983576068 1544 DWYVEKVEIWNDTNEDEFLFLCGRWLS-----LKKEDGRLERL 1581
Cdd:cd01757     70 KWLVEYVMVRNEITGHTYKFPCGRWLGegvddGNGEDGSLERV 112
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 2099-2199 1.51e-08

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 55.24  E-value: 1.51e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 2099 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGK-------RELKQKMRNLFERGSTDRFFLETLEL-GELRKVRLEHDSSG 2170
Cdd:cd01754      3 YTIYVQTGSIWKAGTDSRISLQIYDADGPGLRianleawGGLMGAGHDYFERGNLDRFSGRGPCLpSPPCWMNLTSDGTG 82

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1983576068 2171 YYSGWLVEKVEVtnTSTGVAT-----IFSCGRWL 2199
Cdd:cd01754     83 NHPGWYVNYVEV--TQAGQHApcmqhLFAVEQWL 114
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 45-148 1.84e-08

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 54.47  E-value: 1.84e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068   45 YEVVTATGD-VRGAGTDANVFITIFGENGLSPKLHLTSKS-ESAFEkanvdvfrvrTNNVGLIYKIRIEHDNTGLNASWY 122
Cdd:cd01757      3 YHVVIVPSKkLGGSMFTANPWICVSGELGETPPLQIPKNSlEMTFD----------CQNLGKLTTVQIGHDNSGLLAKWL 72

                           90       100
                   ....*....|....*....|....*.
gi 1983576068  123 LDRVIVTDMKRPHLrYYFNCNNWLSK 148
Cdd:cd01757     73 VEYVMVRNEITGHT-YKFPCGRWLGE 97
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1830-1934 2.60e-08

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 53.80  E-value: 2.60e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  1830 YTVSVKTSDILGAGTDANVFIIIFGENGDSGtLALKQSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKgiFPGWH 1909
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGK-ESKLDYLFKGIFARGSTYEFTFDVDEDFGELGAVKIKNEHR--HPEWF 79

                            90       100
                    ....*....|....*....|....*
gi 1983576068  1910 LSYIDVKDNSRDETFRFQCDCWLSK 1934
Cdd:smart00308   80 LKSITVKDLPTGGKYHFPCNSWVYP 104
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
298-401 4.57e-08

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 53.03  E-value: 4.57e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068   298 YIVTVFTGDIRGAGTKSKIYLVMYGARG-NRNSGKIFLEGGVFDRGRTDIFHIDLAVLLSPLSRVSIGHGNIGvnRGWYC 376
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGdGKESKLDYLFKGIFARGSTYEFTFDVDEDFGELGAVKIKNEHRH--PEWFL 80

                            90       100
                    ....*....|....*....|....*
gi 1983576068   377 EKVVVLCPFTGIQQTFPCSNWLDEK 401
Cdd:smart00308   81 KSITVKDLPTGGKYHFPCNSWVYPD 105
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
553-662 9.58e-08

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 51.87  E-value: 9.58e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068   553 ARYRVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNtdLFEKGNADEFTIESVTMRKVRRVRVRHDGKGSgSG 632
Cdd:smart00308    1 GKYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKG--IFARGSTYEFTFDVDEDFGELGAVKIKNEHRH-PE 77

                            90       100       110
                    ....*....|....*....|....*....|
gi 1983576068   633 WYLDRVLVreEGQPESDNVEFPCLRWLDKD 662
Cdd:smart00308   78 WFLKSITV--KDLPTGGKYHFPCNSWVYPD 105
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 174-287 9.88e-08

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 52.16  E-value: 9.88e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  174 YEIKVYTGD-VIGAGTDADVFINIFGEYGDTGerRLENEKDNFEkgaedkFTLDAPDLGQLMKINVGHNNKGGSAGWFLS 252
Cdd:cd01757      3 YHVVIVPSKkLGGSMFTANPWICVSGELGETP--PLQIPKNSLE------MTFDCQNLGKLTTVQIGHDNSGLLAKWLVE 74

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1983576068  253 KIIIEDIGNKRKYDFPLNRWLALDEDDGKIQRDIL 287
Cdd:cd01757     75 YVMVRNEITGHTYKFPCGRWLGEGVDDGNGEDGSL 109
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1467-1572 1.07e-07

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 51.87  E-value: 1.07e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  1467 YSVQIFTGNVPGAGTDAKVYITIYGDLGDTGERYLGKSENrtNKFEKGTADTFIIE-AADLGVIYKIKLRHDNTKwcADW 1545
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFK--GIFARGSTYEFTFDvDEDFGELGAVKIKNEHRH--PEW 78

                            90       100
                    ....*....|....*....|....*..
gi 1983576068  1546 YVEKVEIWNDTNEDEFLFLCGRWLSLK 1572
Cdd:smart00308   79 FLKSITVKDLPTGGKYHFPCNSWVYPD 105
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 555-666 2.93e-07

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 51.00  E-value: 2.93e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  555 YRVTVCTGE-LEGAGTDANVYLCLFGDVGDTGERLLyncrnntdlfeKGNADEFTIESVTMRKVRRVRVRHDGKGSGSGW 633
Cdd:cd01757      3 YHVVIVPSKkLGGSMFTANPWICVSGELGETPPLQI-----------PKNSLEMTFDCQNLGKLTTVQIGHDNSGLLAKW 71

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1983576068  634 YLDRVLVREEgqPESDNVEFPCLRWLDKDKDDG 666
Cdd:cd01757     72 LVEYVMVRNE--ITGHTYKFPCGRWLGEGVDDG 102
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
45-148 3.36e-07

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 50.33  E-value: 3.36e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068    45 YEVVTATGDVRGAGTDANVFITIFGENGLSPKLHLTSKSESAFEKANVDVFRVRTN-NVGLIYKIRIEHDNTGlnASWYL 123
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGIFARGSTYEFTFDVDeDFGELGAVKIKNEHRH--PEWFL 80

                            90       100
                    ....*....|....*....|....*
gi 1983576068   124 DRVIVTDMKrPHLRYYFNCNNWLSK 148
Cdd:smart00308   81 KSITVKDLP-TGGKYHFPCNSWVYP 104
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 1466-1552 4.46e-07

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 51.00  E-value: 4.46e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1466 LYSVQIFTGNVPGAGTDAKVYITIYGDLGDTG-----ERYLGKSENRTNKFEKGTADTFIIEAADL-GVIYKIKLRHDNT 1539
Cdd:cd01754      2 VYTIYVQTGSIWKAGTDSRISLQIYDADGPGLrianlEAWGGLMGAGHDYFERGNLDRFSGRGPCLpSPPCWMNLTSDGT 81

                           90
                   ....*....|...
gi 1983576068 1540 KWCADWYVEKVEI 1552
Cdd:cd01754     82 GNHPGWYVNYVEV 94
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 1832-1944 5.14e-07

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 50.23  E-value: 5.14e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1832 VSVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNtdtfnfpdmlsLGHLCKLRVWHDNKGIFPGWHLS 1911
Cdd:cd01757      6 VIVPSKKLGGSMFTANPWICVSGELGETPPLQIPKNSLEMTFDCQN-----------LGKLTTVQIGHDNSGLLAKWLVE 74

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1983576068 1912 YIDVKDNSRDETFRFQCDCWLSKSEGDRQTLRD 1944
Cdd:cd01757     75 YVMVRNEITGHTYKFPCGRWLGEGVDDGNGEDG 107
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 1465-1570 6.74e-07

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 50.00  E-value: 6.74e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1465 VLYSVQIFTGNVPGAGTDAKVYITIygdLGDTGERYLGKSENRTNKFEKGTADTFIIEA-ADLGVIYKIKLRHDNTKWCA 1543
Cdd:cd01753      1 AEYKVTVATGSSLFAGTDDYIYLTL---VGTAGESEKQLLDRPGYDFERGAVDEYKVKVpEDLGELLLVRLRKRKYLLFD 77

                           90       100
                   ....*....|....*....|....*..
gi 1983576068 1544 DWYVEKVEIwNDTNEDEFLFLCGRWLS 1570
Cdd:cd01753     78 AWFCNYITV-TGPGGDEYHFPCYRWIE 103
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 555-668 1.26e-06

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 49.46  E-value: 1.26e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  555 YRVTVCTGELEGAGTDANVYLCLFGDVGDTG-----ERLLYNCRNNTDLFEKGNADEFTIESVTMRKVR-RVRVRHDGKG 628
Cdd:cd01754      3 YTIYVQTGSIWKAGTDSRISLQIYDADGPGLrianlEAWGGLMGAGHDYFERGNLDRFSGRGPCLPSPPcWMNLTSDGTG 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1983576068  629 SGSGWYLDRVLVREEGQPESDNVE-FPCLRWLDKDKDDGQL 668
Cdd:cd01754     83 NHPGWYVNYVEVTQAGQHAPCMQHlFAVEQWLATDESPYML 123
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 1313-1433 2.76e-06

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 48.07  E-value: 2.76e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1313 YEITLYTSDVFAAGTDANVFIVIYGCDAVCTRQKFLCTNKReqkllFERKSASRFIVEL-EDVGEIIeKIRIGHDNTGIN 1391
Cdd:cd01753      3 YKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLDRPGYD-----FERGAVDEYKVKVpEDLGELL-LVRLRKRKYLLF 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1983576068 1392 PGWHCSHVDIRRLlpekdGTETLTFPCDRWLatseDDKKTIR 1433
Cdd:cd01753     77 DAWFCNYITVTGP-----GGDEYHFPCYRWI----EGYGTLE 109
PLAT_SR cd02899
Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) ...
 1466-1569 4.31e-06

Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates. This subfamily contains Toxoplasma gondii Scavenger protein TgSR1.


Pssm-ID: 239228  Cd Length: 109  Bit Score: 47.46  E-value: 4.31e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1466 LYSVQIFTGNVPGAGTDAKVYITIYGDLGDTGERYLgksenrTNKFEKGTADTFIIEAADLGVIYKIKLRhdNTKWCADW 1545
Cdd:cd02899      2 TYTASVQTGKDKEAGTNGTIEITLLGSSGRSNPKTL------SQGFYPGSLKRIRFRAADVGDINAIILS--NTALNDPW 73

                           90       100
                   ....*....|....*....|....
gi 1983576068 1546 YVEKVEIWNDTNEdEFLFLCGRWL 1569
Cdd:cd02899     74 YCDYVRIKSEDGK-VFAFNVKRWI 96
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 816-892 4.93e-06

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 47.30  E-value: 4.93e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1983576068  816 YEIEIWTGDVGGAGTTSRVYVQIYGEEGKTEVLFLSSRSKVFDRGSKDIFQLEA-ADVGEIYKIRLGHTGEGFGPSWF 892
Cdd:cd01753      3 YKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLDRPGYDFERGAVDEYKVKVpEDLGELLLVRLRKRKYLLFDAWF 80
PLAT_SR cd02899
Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) ...
 1027-1130 5.44e-06

Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates. This subfamily contains Toxoplasma gondii Scavenger protein TgSR1.


Pssm-ID: 239228  Cd Length: 109  Bit Score: 47.07  E-value: 5.44e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1027 TYEVQVITGNVPKAGTDANVYLTIYGEEyGDTGERPLKKSdksnkFEQGQTDTFTIYAIDLGALTKIRIRhdNTGNRPGW 1106
Cdd:cd02899      2 TYTASVQTGKDKEAGTNGTIEITLLGSS-GRSNPKTLSQG-----FYPGSLKRIRFRAADVGDINAIILS--NTALNDPW 73

                           90       100
                   ....*....|....*....|....
gi 1983576068 1107 FLDRIDITDVNNEtTYYFPCQRWL 1130
Cdd:cd02899     74 YCDYVRIKSEDGK-VFAFNVKRWI 96
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1703-1803 1.16e-05

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 46.10  E-value: 1.16e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  1703 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEVQLDK-KKARFEREQNDTFIMEI-LDIAPFTKMRIRIDglGSRPEWFL 1780
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYlFKGIFARGSTYEFTFDVdEDFGELGAVKIKNE--HRHPEWFL 80

                            90       100
                    ....*....|....*....|...
gi 1983576068  1781 ERILLKNMNTGDLTMFYYGDWLS 1803
Cdd:smart00308   81 KSITVKDLPTGGKYHFPCNSWVY 103
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 816-896 1.44e-05

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 46.77  E-value: 1.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  816 YEIEIWTGDVGGAGTTSRVYVQIYGEEGKT-EVLFLSSRSKV-------FDRGSKDIFQLEAADV-GEIYKIRLGHTGEG 886
Cdd:cd01754      3 YTIYVQTGSIWKAGTDSRISLQIYDADGPGlRIANLEAWGGLmgaghdyFERGNLDRFSGRGPCLpSPPCWMNLTSDGTG 82

                           90
                   ....*....|
gi 1983576068  887 FGPSWFVDTV 896
Cdd:cd01754     83 NHPGWYVNYV 92
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 1829-1933 1.66e-05

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 45.76  E-value: 1.66e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1829 SYTVSVKTSDILGAGTDANVFIIIFGENGDSGTLALKqsaNWNK-FERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPG 1907
Cdd:cd01753      2 EYKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLD---RPGYdFERGAVDEYKVKVPEDLGELLLVRLRKRKYLLFDA 78

                           90       100
                   ....*....|....*....|....*.
gi 1983576068 1908 WHLSYIDVKDNSRDEtFRFQCDCWLS 1933
Cdd:cd01753     79 WFCNYITVTGPGGDE-YHFPCYRWIE 103
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 431-530 5.57e-05

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 44.61  E-value: 5.57e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  431 VWTTDLKKAGTNSPIFIQIYGKKGRTDEILLNPNNKWFKPGIIEKFRMELP-DLG-----RFYKIRAWHDrqnpgSGWHL 504
Cdd:cd01753      7 VATGSSLFAGTDDYIYLTLVGTAGESEKQLLDRPGYDFERGAVDEYKVKVPeDLGelllvRLRKRKYLLF-----DAWFC 81

                           90       100
                   ....*....|....*....|....*.
gi 1983576068  505 EKMTLmNTLNKDKYNFNCNRWLDANE 530
Cdd:cd01753     82 NYITV-TGPGGDEYHFPCYRWIEGYG 106
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 1961-2062 8.12e-05

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 43.87  E-value: 8.12e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1961 YEIVIETGN--GGETRENIWLILEGR-KNRSKEFLVENSSRqraFRKGTTDTFEFDsiFLGDIASLCVGHLAREDrfiPK 2037
Cdd:cd00113      3 YTVTIKTGDkkGAGTDSNISLALYGEnGNSSDIPILDGPGS---FERGSTDTFQID--LKLDIGDITKVYLRRDG---SG 74

                           90       100
                   ....*....|....*....|....*
gi 1983576068 2038 RELVWHVKTITITEMEYGNVYFFNC 2062
Cdd:cd00113     75 LSDGWYCESITVQALGTKKVYTFPV 99
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
815-896 1.07e-04

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 43.40  E-value: 1.07e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068   815 HYEIEIWTGDVGGAGTTSRVYVQIYGEEGKTEVLFLSSRSKV-FDRGSKDIFQLE-AADVGEIYKIRLghTGEGFGPSWF 892
Cdd:smart00308    2 KYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGiFARGSTYEFTFDvDEDFGELGAVKI--KNEHRHPEWF 79


                    ....
gi 1983576068   893 VDTV 896
Cdd:smart00308   80 LKSI 83
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 355-411 1.47e-04

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 43.30  E-value: 1.47e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1983576068  355 LSPLSRVSIGHGNIGVNRGWYCEKVVVLCPFTGIQQTFPCSNWL-----DEKKADGLIERQL 411
Cdd:cd01757     52 LGKLTTVQIGHDNSGLLAKWLVEYVMVRNEITGHTYKFPCGRWLgegvdDGNGEDGSLERVL 113
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 1701-1812 1.67e-04

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 43.07  E-value: 1.67e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1701 VLYEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEVQLDKKKARFEREQNDTFIMEI-LDIAPFTKMRIRIDGLGSRPEWF 1779
Cdd:cd01753      1 AEYKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLDRPGYDFERGAVDEYKVKVpEDLGELLLVRLRKRKYLLFDAWF 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1983576068 1780 LERILLKNMNtGDLTMFYYGDWLSqkkGKKTLV 1812
Cdd:cd01753     81 CNYITVTGPG-GDEYHFPCYRWIE---GYGTLE 109
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 1961-2064 2.48e-04

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 42.65  E-value: 2.48e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1961 YEIVIETG--NGGETRENIWLILEGRKNRSkEFLVENSSRQRAFRKGTTDTFEFDSIF-LGDIASLCVGHLAREDRfiPK 2037
Cdd:cd01752      3 YLVTVFTGwrRGAGTTAKVTITLYGAEGES-EPHHLRDPEKPIFERGSVDSFLLTTPFpLGELQSIRLWHDNSGLS--PS 79

                           90       100
                   ....*....|....*....|....*..
gi 1983576068 2038 relvWHVKTITITEMEYGNVYFFNCDC 2064
Cdd:cd01752     80 ----WYLSRVIVRDLQTGKKWFFLCND 102
PLAT_SR cd02899
Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) ...
 43-148 2.52e-04

Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates. This subfamily contains Toxoplasma gondii Scavenger protein TgSR1.


Pssm-ID: 239228  Cd Length: 109  Bit Score: 42.45  E-value: 2.52e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068   43 KVYEVVTATGDVRGAGTDANVFITIFGENGLSPKLHLTskseSAFEKANVDVFRVRTNNVGLIYKIRIEhdNTGLNASWY 122
Cdd:cd02899      1 KTYTASVQTGKDKEAGTNGTIEITLLGSSGRSNPKTLS----QGFYPGSLKRIRFRAADVGDINAIILS--NTALNDPWY 74

                           90       100
                   ....*....|....*....|....*..
gi 1983576068  123 LDRV-IVTDMKRphlRYYFNCNNWLSK 148
Cdd:cd02899     75 CDYVrIKSEDGK---VFAFNVKRWIGY 98
PLAT_SR cd02899
Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) ...
 2098-2201 6.04e-04

Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates. This subfamily contains Toxoplasma gondii Scavenger protein TgSR1.


Pssm-ID: 239228  Cd Length: 109  Bit Score: 41.29  E-value: 6.04e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 2098 KYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKmrnlFERGSTDRFFLETLELGELRKVRLEHDSSGyySGWLV 2177
Cdd:cd02899      2 TYTASVQTGKDKEAGTNGTIEITLLGSSGRSNPKTLSQG----FYPGSLKRIRFRAADVGDINAIILSNTALN--DPWYC 75

                           90       100
                   ....*....|....*....|....
gi 1983576068 2178 EKVEVtNTSTGVATIFSCGRWLDK 2201
Cdd:cd02899     76 DYVRI-KSEDGKVFAFNVKRWIGY 98
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 1311-1428 1.30e-03

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 40.60  E-value: 1.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1311 VPYEITLYTSD-VFAAGTDANVFIVIYG--CDAvctrqkflctnkreQKLLFERKSASrFIVELEDVGeIIEKIRIGHDN 1387
Cdd:cd01757      1 MPYHVVIVPSKkLGGSMFTANPWICVSGelGET--------------PPLQIPKNSLE-MTFDCQNLG-KLTTVQIGHDN 64

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1983576068 1388 TGINPGWHCSHVDIRRllpEKDGtETLTFPCDRWLATSEDD 1428
Cdd:cd01757     65 SGLLAKWLVEYVMVRN---EITG-HTYKFPCGRWLGEGVDD 101
PLAT_SR cd02899
Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) ...
 1181-1286 2.33e-03

Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates. This subfamily contains Toxoplasma gondii Scavenger protein TgSR1.


Pssm-ID: 239228  Cd Length: 109  Bit Score: 39.75  E-value: 2.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068 1181 TFSVTIKTGDKKNAGTDANVFITLFGtkdNNGMTllkSSKTNSDKFERDSIEIFTVETLDLGDLWKVRIGhdNTGKAPGW 1260
Cdd:cd02899      2 TYTASVQTGKDKEAGTNGTIEITLLG---SSGRS---NPKTLSQGFYPGSLKRIRFRAADVGDINAIILS--NTALNDPW 73

                           90       100
                   ....*....|....*....|....*.
gi 1983576068 1261 FVDWVEVDAPSlGKCMTFPCGRWLAK 1286
Cdd:cd02899     74 YCDYVRIKSED-GKVFAFNVKRWIGY 98
PLAT_SR cd02899
Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) ...
 816-896 3.71e-03

Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates. This subfamily contains Toxoplasma gondii Scavenger protein TgSR1.


Pssm-ID: 239228  Cd Length: 109  Bit Score: 38.98  E-value: 3.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  816 YEIEIWTGDVGGAGTTSRVYVQIYGEEGKTEVLFLssrSKVFDRGSKDIFQLEAADVGEIYKIRLGHTGEgfGPSWFVDT 895
Cdd:cd02899      3 YTASVQTGKDKEAGTNGTIEITLLGSSGRSNPKTL---SQGFYPGSLKRIRFRAADVGDINAIILSNTAL--NDPWYCDY 77


                   .
gi 1983576068  896 V 896
Cdd:cd02899     78 V 78
PLAT_SR cd02899
Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) ...
 173-273 4.20e-03

Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates. This subfamily contains Toxoplasma gondii Scavenger protein TgSR1.


Pssm-ID: 239228  Cd Length: 109  Bit Score: 38.98  E-value: 4.20e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  173 KYEIKVYTGDVIGAGTDADVFINIFGEYGDTGERRLeneKDNFEKGAEDKFTLDAPDLGQLMKINVghNNKGGSAGWFLS 252
Cdd:cd02899      2 TYTASVQTGKDKEAGTNGTIEITLLGSSGRSNPKTL---SQGFYPGSLKRIRFRAADVGDINAIIL--SNTALNDPWYCD 76

                           90       100
                   ....*....|....*....|.
gi 1983576068  253 KIIIEDiGNKRKYDFPLNRWL 273
Cdd:cd02899     77 YVRIKS-EDGKVFAFNVKRWI 96
PLAT_SR cd02899
Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) ...
 1634-1699 6.44e-03

Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates. This subfamily contains Toxoplasma gondii Scavenger protein TgSR1.


Pssm-ID: 239228  Cd Length: 109  Bit Score: 38.60  E-value: 6.44e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1983576068 1634 YYVSVTTGKHKEAATDSRAFVLLIGEdDERTNRIWLdfpqgKRGFSCGSVEEFYVGGLDVGIIKKI 1699
Cdd:cd02899      3 YTASVQTGKDKEAGTNGTIEITLLGS-SGRSNPKTL-----SQGFYPGSLKRIRFRAADVGDINAI 62
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 816-899 8.07e-03

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 38.29  E-value: 8.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983576068  816 YEIEIWTGD-VGGAGTTSRVYVQIYGEEGKTEVLFLSSRSKVFdrgskdifQLEAADVGEIYKIRLGHTGEGFGPSWFVD 894
Cdd:cd01757      3 YHVVIVPSKkLGGSMFTANPWICVSGELGETPPLQIPKNSLEM--------TFDCQNLGKLTTVQIGHDNSGLLAKWLVE 74


                   ....*
gi 1983576068  895 TVWLR 899
Cdd:cd01757     75 YVMVR 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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