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Conserved domains on  [gi|157822725|ref|NP_001099475|]
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glucosamine-6-phosphate isomerase 2 [Rattus norvegicus]

Protein Classification

sugar phosphate isomerase family( domain architecture ID 368)

sugar phosphate isomerase family

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SugarP_isomerase super family cl00339
SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate ...
 1-253 9.11e-152

SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium, the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate. 6PGL converts 6-phosphoglucono-1,5-lactone to 6-phosphogluconate, the second step of the oxidative phase of the pentose phosphate pathway.


The actual alignment was detected with superfamily member PTZ00285:

Pssm-ID: 469729  Cd Length: 253  Bit Score: 423.78  E-value: 9.11e-152
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725   1 MRLVILDNYDLASEWAAKYICNRIIKFKPGQDRYFSLGLPTGSTPLGCYKKLIEYHKSGNLSFKYVKTFNMDEYVGLPRN 80
Cdd:PTZ00285   1 MRIVISEDADAVADYTSNYIIKRINDFKPTSDRPFVLGLPTGSTPLPTYQELIRAYREGRVSFSNVVTFNMDEYVGLPRD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725  81 HPESYHSYMWNNFFKHIDIDPNNAHILDGNAADLQAECDAFEEKIKEAGGIDLFVGGIGPDGHIAFNEPGSSLVSRTRLK 160
Cdd:PTZ00285  81 HPQSYHYFMKENFFDHVDIKEENRHILNGTAPDLEEECRRYEEKIRAVGGIDLFLAGIGTDGHIAFNEPGSSLDSRTRVK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725 161 TLAMDTILANAKYFDGDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTIFVCD 240
Cdd:PTZ00285 161 SLNQETIDANARFFGNDISKVPTMALTVGIRTIMEAREVLLLATGASKAIAVARCVEGGVTHMCPASALQMHPAAVLCLD 240

                        250
                 ....*....|...
gi 157822725 241 EDATLELRVKTVK 253
Cdd:PTZ00285 241 EDATLELKVKTTK 253
 
Name Accession Description Interval E-value
PTZ00285 PTZ00285
glucosamine-6-phosphate isomerase; Provisional
 1-253 9.11e-152

glucosamine-6-phosphate isomerase; Provisional


Pssm-ID: 140308  Cd Length: 253  Bit Score: 423.78  E-value: 9.11e-152
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725   1 MRLVILDNYDLASEWAAKYICNRIIKFKPGQDRYFSLGLPTGSTPLGCYKKLIEYHKSGNLSFKYVKTFNMDEYVGLPRN 80
Cdd:PTZ00285   1 MRIVISEDADAVADYTSNYIIKRINDFKPTSDRPFVLGLPTGSTPLPTYQELIRAYREGRVSFSNVVTFNMDEYVGLPRD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725  81 HPESYHSYMWNNFFKHIDIDPNNAHILDGNAADLQAECDAFEEKIKEAGGIDLFVGGIGPDGHIAFNEPGSSLVSRTRLK 160
Cdd:PTZ00285  81 HPQSYHYFMKENFFDHVDIKEENRHILNGTAPDLEEECRRYEEKIRAVGGIDLFLAGIGTDGHIAFNEPGSSLDSRTRVK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725 161 TLAMDTILANAKYFDGDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTIFVCD 240
Cdd:PTZ00285 161 SLNQETIDANARFFGNDISKVPTMALTVGIRTIMEAREVLLLATGASKAIAVARCVEGGVTHMCPASALQMHPAAVLCLD 240

                        250
                 ....*....|...
gi 157822725 241 EDATLELRVKTVK 253
Cdd:PTZ00285 241 EDATLELKVKTTK 253
nagB TIGR00502
glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a ...
 1-258 7.35e-142

glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a closely related pair from Bacillus subtilis, one of which is uncharacterized but included as a member of the orthologous set. [Central intermediary metabolism, Amino sugars]


Pssm-ID: 129593  Cd Length: 259  Bit Score: 399.19  E-value: 7.35e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725    1 MRLVILDNYDLASEWAAKYICNRIIKFKPGQDRYFSLGLPTGSTPLGCYKKLIEYHKSGNLSFKYVKTFNMDEYVGLPRN 80
Cdd:TIGR00502   1 MRLIILQTYEELSKWAARHIANRINEFKPTAARPFVLGLPTGGTPIGTYKQLIELHQAGKISFQNVTTFNMDEYAGLSEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725   81 HPESYHSYMWNNFFKHIDIDPNNAHILDGNAADLQAECDAFEEKIKEAGGIDLFVGGIGPDGHIAFNEPGSSLVSRTRLK 160
Cdd:TIGR00502  81 HPESYHSFMHNNFFQHIDIKPENINILNGNAPDLEAECRRYEEKIRSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRTRIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725  161 TLAMDTILANAKYFDGDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTIFVCD 240
Cdd:TIGR00502 161 TLTEDTIQANSRFFEGDVNQVPKYALTVGIGTILDSKEVLILVSGHQKALALQKAVEGGVNHMWTISALQLHKHAIVVCD 240

                         250
                  ....*....|....*...
gi 157822725  241 EDATLELRVKTVKYFKGL 258
Cdd:TIGR00502 241 ENATQELKVKTVEYFNEL 258
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 12-247 1.88e-139

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 391.85  E-value: 1.88e-139
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725  12 ASEWAAKYICNRIIKFKPgqdryFSLGLPTGSTPLGCYKKLIEYHKSGNLSFKYVKTFNMDEYVGLPRNHPESYHSYMWN 91
Cdd:cd01399    3 MSEAAAELIAELIREKPP-----AVLGLATGSTPLGVYEELIELHKEGGLSFSNVTTFNLDEYVGLPPDHPQSYHYFMRE 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725  92 NFFKHIDIDPNNAHILDGNAADLQAECDAFEEKIKEAGGIDLFVGGIGPDGHIAFNEPGSSLVSRTRLKTLAMDTILANA 171
Cdd:cd01399   78 NLFDHIDIKPENIHIPDGNAADLEAECRRYEALIAEAGGIDLQLLGIGENGHIGFNEPGSSLDSRTRVVTLDESTRQANA 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 157822725 172 KYFDGDlSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTIFVCDEDATLEL 247
Cdd:cd01399  158 RFFDGD-EDVPTQAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPASILQLHPNVTVILDEAAASEL 232
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 1-247 3.23e-116

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 333.67  E-value: 3.23e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725   1 MRLVILDNYDLASEWAAKYICNRI---IKFKPgqdrYFSLGLPTGSTPLGCYKKLIEYHKSGNLSFKYVKTFNMDEYVGL 77
Cdd:COG0363    2 MRVIIFPDAEELAAAAAERAAERIaeaIAEKG----RAVLGLAGGSTPLGLYEELARLHKEGGLDWSRVHVFNLDEYVGL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725  78 PRNHPESYHSYMWNNFFKHIDIDPNNAHILDGNAADLQAECDAFEEKIKEAGGIDLFVGGIGPDGHIAFNEPGSSLVSRT 157
Cdd:COG0363   78 PPDHPQSNRRFMREALLDHVDIPPENIHIPDGEAEDPEAAAARYEALIAEAGGIDLQLLGIGEDGHIAFNFPGSPFLSET 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725 158 -RLKTLAMDTILANAKYFDgDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTI 236
Cdd:COG0363  158 dRVVTLDESTRQANARFFG-SIPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPASILQGHPNVT 236

                        250
                 ....*....|.
gi 157822725 237 FVCDEDATLEL 247
Cdd:COG0363  237 WFLDEAAASLL 247
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
16-223 3.67e-21

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 88.83  E-value: 3.67e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725   16 AAKYICNRIiKFKPGQDRYFSLGLPTGSTPLGCYKKLIEYHKSgnLSFKYVKTFNMDE-YVglPRNHPES-YHSYMwNNF 93
Cdd:pfam01182  10 LAERLAEAL-EAALAERGRFTLALSGGSTPKPLYELLAAAPAR--LDWSRVHVFWGDErCV--PPDDPDSnYGMAR-EAL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725   94 FKHIDIDPNNAHILDGNAADLQAECDAFEEKIKEAGG------IDLFVGGIGPDGHIA--FnePGSSLVSRTRLKTLAMD 165
Cdd:pfam01182  84 LSHVPIPASNVHPIPASAADPEEAAAAYEAELRELLPdlelpvFDLVLLGMGPDGHTAslF--PGSPALEETDRLVVAVT 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 157822725  166 tilanakyfdgDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHM 223
Cdd:pfam01182 162 -----------DSPKPPPERITLTLPVLNAARRVWFLVTGAGKADALRRALAGDPDPL 208
 
Name Accession Description Interval E-value
PTZ00285 PTZ00285
glucosamine-6-phosphate isomerase; Provisional
 1-253 9.11e-152

glucosamine-6-phosphate isomerase; Provisional


Pssm-ID: 140308  Cd Length: 253  Bit Score: 423.78  E-value: 9.11e-152
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725   1 MRLVILDNYDLASEWAAKYICNRIIKFKPGQDRYFSLGLPTGSTPLGCYKKLIEYHKSGNLSFKYVKTFNMDEYVGLPRN 80
Cdd:PTZ00285   1 MRIVISEDADAVADYTSNYIIKRINDFKPTSDRPFVLGLPTGSTPLPTYQELIRAYREGRVSFSNVVTFNMDEYVGLPRD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725  81 HPESYHSYMWNNFFKHIDIDPNNAHILDGNAADLQAECDAFEEKIKEAGGIDLFVGGIGPDGHIAFNEPGSSLVSRTRLK 160
Cdd:PTZ00285  81 HPQSYHYFMKENFFDHVDIKEENRHILNGTAPDLEEECRRYEEKIRAVGGIDLFLAGIGTDGHIAFNEPGSSLDSRTRVK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725 161 TLAMDTILANAKYFDGDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTIFVCD 240
Cdd:PTZ00285 161 SLNQETIDANARFFGNDISKVPTMALTVGIRTIMEAREVLLLATGASKAIAVARCVEGGVTHMCPASALQMHPAAVLCLD 240

                        250
                 ....*....|...
gi 157822725 241 EDATLELRVKTVK 253
Cdd:PTZ00285 241 EDATLELKVKTTK 253
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 1-258 1.22e-151

glucosamine-6-phosphate deaminase; Provisional


Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 423.86  E-value: 1.22e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725   1 MRLVILDNYDLASEWAAKYICNRIIKFKPGQDRYFSLGLPTGSTPLGCYKKLIEYHKSGNLSFKYVKTFNMDEYVGLPRN 80
Cdd:PRK00443   1 MRLIILKTAEEVGKWAARHIANRINAFLPTKERPFVLGLATGSSPLETYKALIELHKAGKVDFSRVTTFNLDEYVGLPAD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725  81 HPESYHSYMWNNFFKHIDIDPNNAHILDGNAADLQAECDAFEEKIKEAGGIDLFVGGIGPDGHIAFNEPGSSLVSRTRLK 160
Cdd:PRK00443  81 HPESYRYFMRENFFDHVDIPPENINLLNGNAPDPEAECRRYEEKIKSAGGIDLQILGIGENGHIAFNEPGSSFASRTRIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725 161 TLAMDTILANAKYFDGDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTIFVCD 240
Cdd:PRK00443 161 TLTEDTRIANSRFFDGDIEQVPKYALTVGVGTILDAKEIMLLAPGHNKAEAVKAAVEGPVNHMWPASILQLHPKATLVLD 240

                        250
                 ....*....|....*...
gi 157822725 241 EDATLELRVKTVKYFKGL 258
Cdd:PRK00443 241 EAAASELKVKTVKYFTEL 258
nagB TIGR00502
glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a ...
 1-258 7.35e-142

glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a closely related pair from Bacillus subtilis, one of which is uncharacterized but included as a member of the orthologous set. [Central intermediary metabolism, Amino sugars]


Pssm-ID: 129593  Cd Length: 259  Bit Score: 399.19  E-value: 7.35e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725    1 MRLVILDNYDLASEWAAKYICNRIIKFKPGQDRYFSLGLPTGSTPLGCYKKLIEYHKSGNLSFKYVKTFNMDEYVGLPRN 80
Cdd:TIGR00502   1 MRLIILQTYEELSKWAARHIANRINEFKPTAARPFVLGLPTGGTPIGTYKQLIELHQAGKISFQNVTTFNMDEYAGLSEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725   81 HPESYHSYMWNNFFKHIDIDPNNAHILDGNAADLQAECDAFEEKIKEAGGIDLFVGGIGPDGHIAFNEPGSSLVSRTRLK 160
Cdd:TIGR00502  81 HPESYHSFMHNNFFQHIDIKPENINILNGNAPDLEAECRRYEEKIRSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRTRIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725  161 TLAMDTILANAKYFDGDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTIFVCD 240
Cdd:TIGR00502 161 TLTEDTIQANSRFFEGDVNQVPKYALTVGIGTILDSKEVLILVSGHQKALALQKAVEGGVNHMWTISALQLHKHAIVVCD 240

                         250
                  ....*....|....*...
gi 157822725  241 EDATLELRVKTVKYFKGL 258
Cdd:TIGR00502 241 ENATQELKVKTVEYFNEL 258
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 12-247 1.88e-139

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 391.85  E-value: 1.88e-139
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725  12 ASEWAAKYICNRIIKFKPgqdryFSLGLPTGSTPLGCYKKLIEYHKSGNLSFKYVKTFNMDEYVGLPRNHPESYHSYMWN 91
Cdd:cd01399    3 MSEAAAELIAELIREKPP-----AVLGLATGSTPLGVYEELIELHKEGGLSFSNVTTFNLDEYVGLPPDHPQSYHYFMRE 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725  92 NFFKHIDIDPNNAHILDGNAADLQAECDAFEEKIKEAGGIDLFVGGIGPDGHIAFNEPGSSLVSRTRLKTLAMDTILANA 171
Cdd:cd01399   78 NLFDHIDIKPENIHIPDGNAADLEAECRRYEALIAEAGGIDLQLLGIGENGHIGFNEPGSSLDSRTRVVTLDESTRQANA 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 157822725 172 KYFDGDlSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTIFVCDEDATLEL 247
Cdd:cd01399  158 RFFDGD-EDVPTQAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPASILQLHPNVTVILDEAAASEL 232
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 1-247 3.23e-116

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 333.67  E-value: 3.23e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725   1 MRLVILDNYDLASEWAAKYICNRI---IKFKPgqdrYFSLGLPTGSTPLGCYKKLIEYHKSGNLSFKYVKTFNMDEYVGL 77
Cdd:COG0363    2 MRVIIFPDAEELAAAAAERAAERIaeaIAEKG----RAVLGLAGGSTPLGLYEELARLHKEGGLDWSRVHVFNLDEYVGL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725  78 PRNHPESYHSYMWNNFFKHIDIDPNNAHILDGNAADLQAECDAFEEKIKEAGGIDLFVGGIGPDGHIAFNEPGSSLVSRT 157
Cdd:COG0363   78 PPDHPQSNRRFMREALLDHVDIPPENIHIPDGEAEDPEAAAARYEALIAEAGGIDLQLLGIGEDGHIAFNFPGSPFLSET 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725 158 -RLKTLAMDTILANAKYFDgDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTI 236
Cdd:COG0363  158 dRVVTLDESTRQANARFFG-SIPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPASILQGHPNVT 236

                        250
                 ....*....|.
gi 157822725 237 FVCDEDATLEL 247
Cdd:COG0363  237 WFLDEAAASLL 247
PRK02122 PRK02122
glucosamine-6-phosphate deaminase-like protein; Validated
 13-251 4.68e-78

glucosamine-6-phosphate deaminase-like protein; Validated


Pssm-ID: 235005 [Multi-domain]  Cd Length: 652  Bit Score: 248.79  E-value: 4.68e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725  13 SEWAAKYICNRI---IKFKPGQDRYFSLGLPTGSTPLGCYKKLIEYHKSGNLSFKYVKTFNMDEYVGLPRNHPESYHSYM 89
Cdd:PRK02122  36 SEEASRAVAQEIatlIRERQAEGKPCVLGLATGSSPIGVYAELIRMHREEGLSFKNVITFNLDEYYPMQPDSLQSYHRFM 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725  90 WNNFFKHIDIDPNNAHILDG--NAADLQAECDAFEEKIKEAGGIDLFVGGIGPDGHIAFNEPGSSLVSRTRLKTLAMDTI 167
Cdd:PRK02122 116 KENLFDHVDIPPENIHIPDGtiPKEEIDEYCRDYEEKIEAAGGIDFQLLGIGRTGHIGFNEPGSGRNSRTRLVTLDHITR 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725 168 LANAKYFdGDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTIFVCDEDATLEL 247
Cdd:PRK02122 196 RDAASDF-FGEENVPRKAITMGVGTILKARRIVLLAWGEHKAPIIKRAVEGEISDEVPASYLQEHPNATFVLDLAAASEL 274


                 ....*
gi 157822725 248 -RVKT 251
Cdd:PRK02122 275 tRIKT 279
SugarP_isomerase cd00458
SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate ...
 14-239 5.31e-39

SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium, the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate. 6PGL converts 6-phosphoglucono-1,5-lactone to 6-phosphogluconate, the second step of the oxidative phase of the pentose phosphate pathway.


Pssm-ID: 238258  Cd Length: 169  Bit Score: 134.40  E-value: 5.31e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725  14 EWAAKYICNRIIKFkPGQDRYFSLGLPTGSTPLGCYKKLIEYHKSGnlSFKYVKTFNMDEYVGLPRnHPESYHSYMWNNF 93
Cdd:cd00458    2 KEALKFIEDK*EKL-LEEKDDMVIGLGTGSTPAYFYKLLGEKLKRG--EISDIVGFPTDERYVPLD-SDQSNFRQAKLLA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725  94 FKHIDIDPNNAHILDGNAADLQAECDAFEEKIKEAGGIDLFVGGIGpdghiafnepgsslvsrtrlktlamdtilanaky 173
Cdd:cd00458   78 FEHDIIPASNVHYVDTSLPIEKACEKYEREILDQVDAIDLAVDGAG---------------------------------- 123

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 157822725 174 fdgdlskvptmaltvgvgtvMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTIFVC 239
Cdd:cd00458  124 --------------------YRAGTVIVLVDGRKKVDYLCQNTEPGVIENGIFADIRGKEKDIVIV 169
PRK12358 PRK12358
glucosamine-6-phosphate deaminase;
1-247 1.51e-31

glucosamine-6-phosphate deaminase;


Pssm-ID: 183470  Cd Length: 239  Bit Score: 116.77  E-value: 1.51e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725   1 MRLVILDNYDLASEWAAKYICNRIIkfkpgQDRYFSLGLPTGSTPLGCYKKLIEYHKSGNLsFKYVKTFNMDEyvgLPRN 80
Cdd:PRK12358   1 MKIIITKDYEEMSRVAAHHLLGYMS-----KTKRVNLAITAGSTPKGMYEYLITLVKGKAW-YDNVHYYNFDE---IPFR 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725  81 HPESYH---SYMWNNFFKHIDIDPNNAHILDgnaADLQAEcdaFEEKIKEAGGIDLFVGGIGPDGHIAFNEPG-SSLVSR 156
Cdd:PRK12358  72 GKEGEGvtiTNLRNLFFTPAGIKEENIHKLT---IDNYRE---HDQKLARDGGLDLVVLGLGADGHFCGNLPGtTHFHDE 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725 157 TRLKTLA--MDTILANAKyFDGDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPR 234
Cdd:PRK12358 146 TVEVPIQgeMVDIVAHGE-LGGDFSLVPDSYVTMGPKSIMAAKNLLLIVNGKGKAQILKKVLQGPVTEDVPASILQLHPN 224

                        250
                 ....*....|...
gi 157822725 235 TIFVCDEDATLEL 247
Cdd:PRK12358 225 LTVILDEAAAAEL 237
PRK09762 PRK09762
galactosamine-6-phosphate isomerase; Provisional
 1-236 4.68e-31

galactosamine-6-phosphate isomerase; Provisional


Pssm-ID: 182064  Cd Length: 232  Bit Score: 115.31  E-value: 4.68e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725   1 MRLVILDNYDLASEWAAKYICNRIikfkpGQDRYFSLGLPTGSTPLGCYKKLIEYHKSGNLSFKYVKTFNMDEYVGLPRN 80
Cdd:PRK09762   1 QTLQQVENYTALSERASEYLLAVI-----RSKPDAVICLATGATPLLTYHYLVEKIHQQQVDVSQLTFVKLDEWVDLPLT 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725  81 HPESYHSYMWNNFFKHIDIDPNNAHILDGNAADlQAECDAFEEKIKEAGGIDLFVGGIGPDGHIAFNEPGSSL-----VS 155
Cdd:PRK09762  76 MPGTCETFLQQHIVQPLGLREDQLISFRSEEIN-ETECERVTNLIARKGGLDLCVLGLGKNGHLGLNEPGESLqpachIS 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725 156 RTRLKTLAMDTILANakyfdgdlSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRT 235
Cdd:PRK09762 155 QLDARTQQHEMLKTA--------GRPVTRGITLGLKDILNAREVLLLVTGEGKQDATERFLTAKVSTAIPASFLWLHSNF 226


                 .
gi 157822725 236 I 236
Cdd:PRK09762 227 I 227
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
16-223 3.67e-21

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 88.83  E-value: 3.67e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725   16 AAKYICNRIiKFKPGQDRYFSLGLPTGSTPLGCYKKLIEYHKSgnLSFKYVKTFNMDE-YVglPRNHPES-YHSYMwNNF 93
Cdd:pfam01182  10 LAERLAEAL-EAALAERGRFTLALSGGSTPKPLYELLAAAPAR--LDWSRVHVFWGDErCV--PPDDPDSnYGMAR-EAL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725   94 FKHIDIDPNNAHILDGNAADLQAECDAFEEKIKEAGG------IDLFVGGIGPDGHIA--FnePGSSLVSRTRLKTLAMD 165
Cdd:pfam01182  84 LSHVPIPASNVHPIPASAADPEEAAAAYEAELRELLPdlelpvFDLVLLGMGPDGHTAslF--PGSPALEETDRLVVAVT 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 157822725  166 tilanakyfdgDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHM 223
Cdd:pfam01182 162 -----------DSPKPPPERITLTLPVLNAARRVWFLVTGAGKADALRRALAGDPDPL 208
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 10-239 6.41e-21

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 88.00  E-value: 6.41e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725  10 DLAsEWAAKYICNRI---IKfkpgQDRYFSLGLPTGSTPLGCYKKLIEYHKsgnLSFKYVKTFNMDE-YVglPRNHPES- 84
Cdd:cd01400    2 ALA-EALADRIAEALaaaIA----KRGRFSLALSGGSTPKPLYELLAAAPA---LDWSKVHVFLGDErCV--PPDDPDSn 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725  85 YHSYMwNNFFKHIDIDPNNAHILDGnAADLQAECDAFEEKIKEAGG----IDLFVGGIGPDGHIA--FnePGSSLVSRTR 158
Cdd:cd01400   72 YRLAR-EALLSHVAIPAANIHPIPT-ELGPEDAAAAYEKELRALFGgvppFDLVLLGMGPDGHTAslF--PGHPALLEET 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725 159 LKT-LAMDtilanakyfdgDLSKVPT--MALTVGVgtVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRT 235
Cdd:cd01400  148 DRLvVAVT-----------DSPKPPPerITLTLPV--LNNARRVVFLVTGAEKAEALKRALAGPDPEELPAARVLPRPGE 214


                 ....
gi 157822725 236 IFVC 239
Cdd:cd01400  215 VLWF 218
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 5-247 4.90e-15

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 72.41  E-value: 4.90e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725    5 ILDNYDLASEWAAKYICNRIIKFKPGQDRyFSLGLPTGSTPLGCYKKLIEyhksGNLSFKYVKTFNMDE-YVglPRNHPE 83
Cdd:TIGR01198   1 VFSNSAELAEALAERIATKLQTALAERGQ-FSLALSGGRSPIALLEALAA----QPLDWSRIHLFLGDErYV--PLDHAD 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725   84 S----YHSYMwnnfFKHIDIDPNNAHILDGNAADLQAECDAFEEKIKEA------GGIDLFVGGIGPDGHIAFNEPGSSL 153
Cdd:TIGR01198  74 SntglAREAL----LDRVAIPASNIHPMPTELSDIEEAAELYEQELAAAfqpivfPVFDLLLLGMGPDGHTASLFPHTPA 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725  154 V-SRTRLKTLAMDTIlanakyfdgdlsKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIE-EGVNHMWTVSAFQQ 231
Cdd:TIGR01198 150 LqETERLVTVLTKSP------------KPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALAvEAEPYPLPAAGVLH 217

                         250
                  ....*....|....*.
gi 157822725  232 HPRTIFVCDEDATLEL 247
Cdd:TIGR01198 218 SGKTLWLLDYAAARKL 233
PLN02360 PLN02360
probable 6-phosphogluconolactonase
 34-219 1.68e-06

probable 6-phosphogluconolactonase


Pssm-ID: 166001 [Multi-domain]  Cd Length: 268  Bit Score: 48.32  E-value: 1.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725  34 YFSLGLPTGSTpLGCYKKLIE--YHKSGNLSFKYVktFNMDEYVgLPRNHPESYHSYMWNNFFKHIDIDPNNAHILDGNA 111
Cdd:PLN02360  43 VFAIALSGGSL-ISFMGKLCEapYNKTVDWAKWYI--FWADERV-VAKNHADSNYKLAKDGLLSKVPVVPSHVYSINDTV 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822725 112 ADLQAECDaFE--------------EKIKEAGGIDLFVGGIGPDGHIAfnepgsSLVSRTRLKTLAMDTILanakyFDGD 177
Cdd:PLN02360 119 TAEEAATD-YEfairqlvktrtigvSDISDCPKFDLILLGMGSDGHVA------SLFPNHPALEEKDDWVT-----FITD 186

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 157822725 178 LSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEG 219
Cdd:PLN02360 187 SPKPPPERITFTLPVINSASNVAVVATGESKANAVHLAIDDV 228
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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