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Conserved domains on  [gi|157822179|ref|NP_001099474|]
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COMM domain-containing protein 8 [Rattus norvegicus]

Protein Classification

COMM domain-containing protein 8( domain architecture ID 10140836)

COMM domain-containing protein 8 (COMMD8) may modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes and may also down-regulate activation of NF-kappa-B

Gene Symbol:  COMMD8
Gene Ontology:  GO:0005515
PubMed:  15799966
SCOP:  4005215

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Commd8 cd04756
COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of ...
 7-182 4.00e-90

COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


:

Pssm-ID: 240104 [Multi-domain]  Cd Length: 176  Bit Score: 260.81  E-value: 4.00e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822179   7 TPLWRLQKLPPEQGAGLLHKIIDGICGRAYPAHQDYHSVWNSTEWKHVLEDVTTFFKAVVGKNFSEEETLQQLNQLNSCH 86
Cdd:cd04756    1 TPPELINLLPVAQIVKLLHRVVDGVCGRAYPRYQDYSAIWSLEEWTEVLESLATLFKQAVGKNSNDEEAKAQLSDLSSSH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822179  87 QEAVMKCLKSRKNEIKQALLGEIVDISCAQLQDFDWQLKLALSSDKIATLQMPLLNLHLDVKEDGEVKPYSVEMSKEELQ 166
Cdd:cd04756   81 QEALLKCVKSRKEEIRQALVNKTNSISSAQLQDFDWQLKLALSSDKLSSLQEPLLNLDLDVKENGILKPVSIEMNKEELQ 160

                        170
                 ....*....|....*.
gi 157822179 167 SLISSLEAANKVVLQL 182
Cdd:cd04756  161 NLISSLEAANKVVLQL 176
 
Name Accession Description Interval E-value
Commd8 cd04756
COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of ...
 7-182 4.00e-90

COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240104 [Multi-domain]  Cd Length: 176  Bit Score: 260.81  E-value: 4.00e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822179   7 TPLWRLQKLPPEQGAGLLHKIIDGICGRAYPAHQDYHSVWNSTEWKHVLEDVTTFFKAVVGKNFSEEETLQQLNQLNSCH 86
Cdd:cd04756    1 TPPELINLLPVAQIVKLLHRVVDGVCGRAYPRYQDYSAIWSLEEWTEVLESLATLFKQAVGKNSNDEEAKAQLSDLSSSH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822179  87 QEAVMKCLKSRKNEIKQALLGEIVDISCAQLQDFDWQLKLALSSDKIATLQMPLLNLHLDVKEDGEVKPYSVEMSKEELQ 166
Cdd:cd04756   81 QEALLKCVKSRKEEIRQALVNKTNSISSAQLQDFDWQLKLALSSDKLSSLQEPLLNLDLDVKENGILKPVSIEMNKEELQ 160

                        170
                 ....*....|....*.
gi 157822179 167 SLISSLEAANKVVLQL 182
Cdd:cd04756  161 NLISSLEAANKVVLQL 176
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 113-175 2.55e-14

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 64.11  E-value: 2.55e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157822179  113 SCAQLQDFDWQLKLALSSDKIATLQMPLLNLHLDVKE-DGEVKPYSVEMSKEELQSLISSLEAA 175
Cdd:pfam07258   1 SLPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSDgDGSSEEVTFELSKEQLQDLLNELEEA 64
 
Name Accession Description Interval E-value
Commd8 cd04756
COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of ...
 7-182 4.00e-90

COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240104 [Multi-domain]  Cd Length: 176  Bit Score: 260.81  E-value: 4.00e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822179   7 TPLWRLQKLPPEQGAGLLHKIIDGICGRAYPAHQDYHSVWNSTEWKHVLEDVTTFFKAVVGKNFSEEETLQQLNQLNSCH 86
Cdd:cd04756    1 TPPELINLLPVAQIVKLLHRVVDGVCGRAYPRYQDYSAIWSLEEWTEVLESLATLFKQAVGKNSNDEEAKAQLSDLSSSH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822179  87 QEAVMKCLKSRKNEIKQALLGEIVDISCAQLQDFDWQLKLALSSDKIATLQMPLLNLHLDVKEDGEVKPYSVEMSKEELQ 166
Cdd:cd04756   81 QEALLKCVKSRKEEIRQALVNKTNSISSAQLQDFDWQLKLALSSDKLSSLQEPLLNLDLDVKENGILKPVSIEMNKEELQ 160

                        170
                 ....*....|....*.
gi 157822179 167 SLISSLEAANKVVLQL 182
Cdd:cd04756  161 NLISSLEAANKVVLQL 176
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 113-175 2.55e-14

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 64.11  E-value: 2.55e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157822179  113 SCAQLQDFDWQLKLALSSDKIATLQMPLLNLHLDVKE-DGEVKPYSVEMSKEELQSLISSLEAA 175
Cdd:pfam07258   1 SLPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSDgDGSSEEVTFELSKEQLQDLLNELEEA 64
Commd cd04748
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene ...
 93-179 1.35e-12

COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. HCaRG, a nuclear protein that might be involved in cell proliferation, is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals.


Pssm-ID: 240096  Cd Length: 87  Bit Score: 60.40  E-value: 1.35e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822179  93 CLKSRKNEIKQALLGEivDISCAQLQDFDWQLKLALSSDKIATLQMP--LLNLHLDVKEDGEVKPYSVEMSKEELQSLIS 170
Cdd:cd04748    1 LLTENKAEIEELLSKQ--SLSLPQLVDFDWRLDVQISSSSLAKVKQPtiLVQLKLQVGDNNSSEKICFEMTKEELQNFLN 78


                 ....*....
gi 157822179 171 SLEAANKVV 179
Cdd:cd04748   79 KLKKIKAQL 87
Commd4 cd04752
COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of ...
 65-175 6.73e-06

COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240100 [Multi-domain]  Cd Length: 174  Bit Score: 44.34  E-value: 6.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822179  65 VVGKNFSEEetLQQLNqLNSCHQEAVMKCLKSRKNEIKQALLGEIVDIScaQLQDFDWQLKLALSSDKIATLQMPLLNLH 144
Cdd:cd04752   60 VDGESLSSE--LQQLG-LPKEHATSLCRSYEEKQSKLQESLRANSLRLS--RLESVDWRVDYILSSSELQEVNEPLVQLR 134

                         90       100       110
                 ....*....|....*....|....*....|...
gi 157822179 145 LDVK--EDGEVKPYSVEMSKEELQSLISSLEAA 175
Cdd:cd04752  135 LKVRnaDTGEITPHPFSVSADKFRVLLAELKQA 167
Commd9 cd04757
COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of ...
 112-172 1.55e-04

COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240105  Cd Length: 108  Bit Score: 39.47  E-value: 1.55e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157822179 112 ISCAQLQDFDWQLKLALSSDKIATLQMPLLNLHLDVKEDGEVK-------PYSVEMSKEELQSLISSL 172
Cdd:cd04757   29 ISLPKLVDHDWRVDIKTSSDSLGRMAVPTCLLQMKIQEAPSLCgllpplsTLTMELSKETLDTMLDGL 96
Commd6 cd04754
COMM_Domain containing protein 6. The COMM Domain is found at the C-terminus of a variety of ...
 116-167 3.52e-04

COMM_Domain containing protein 6. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240102  Cd Length: 86  Bit Score: 37.98  E-value: 3.52e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 157822179 116 QLQDFDWQLKLALSSDKIATLQMPLLNLHLDVKE-DGEVKPYSVEMSKEELQS 167
Cdd:cd04754   21 QLVDFKWKLGMAVSSDTCRSLNSPYVAVTLKVADpSGQVVTKSFEMTIPEFQN 73
Commd10 cd04758
COMM_Domain containing protein 10. The COMM Domain is found at the C-terminus of a variety of ...
 116-173 9.76e-03

COMM_Domain containing protein 10. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240106 [Multi-domain]  Cd Length: 186  Bit Score: 35.43  E-value: 9.76e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 157822179 116 QLQDFDWQLKLALSSDKIATLQMPLLNLHLDVK-EDGEVKPYSVEMSKEELQSLISSLE 173
Cdd:cd04758  119 QLEDVSWRLNLQMSSSTQAKLKSPLAVLELGVTsEDGNLEKINLEFNHEELLEFYNQLE 177
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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